Aliases & Classifications for Idiopathic Edema

MalaCards integrated aliases for Idiopathic Edema:

Name: Idiopathic Edema 54 74
Idiopathic Orthostatic Edema 54
Fluid Retention Syndrome 54
Idiopathic Cyclic Edema 54
Body Fluid Retention 74
Edema Idiopathic 56
Fluid Retention 56
Cyclical Edema 54

Classifications:



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Summaries for Idiopathic Edema

NIH Rare Diseases : 54 Idiopathic edema is a common cause of fluid retention and swelling (edema) in women. "Idiopathic" means that the cause of this condition is unknown. Idiopathic edema occurs in the absence of heart, kidney, or liver disease. It is often associated with diabetes, obesity, and emotional problems. The edema may develop periodically or it may persist over time. Swelling of the face, hands, and legs can develop rapidly, and affected individuals typically experience significant changes in their weight over the course of a day. Treatment often includes a low sodium and carbohydrate diet as well as cessation of diuretic therapy (if warranted).

MalaCards based summary : Idiopathic Edema, also known as idiopathic orthostatic edema, is related to microvascular complications of diabetes 3 and pulmonary edema, and has symptoms including edema An important gene associated with Idiopathic Edema is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are Glucose / Energy Metabolism and MicroRNAs in cardiomyocyte hypertrophy. Affiliated tissues include kidney, liver and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Idiopathic Edema

Diseases related to Idiopathic Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 29.8 ACE INS
2 pulmonary edema 29.4 ACE EDN1 NPPA NPPB
3 hypokalemia 29.2 ACE AQP2 NR3C2
4 congestive heart failure 29.1 ACE ADM EDN1 NPPA NPPB NR3C2
5 sleep apnea 28.8 ACE ADIPOQ EDN1 INS NPPB
6 diabetes mellitus 28.5 ACE ADIPOQ EDN1 INS PPARA PPARG
7 liver cirrhosis 28.2 ADIPOQ ADM AQP2 EDN1 NPPA
8 hepatic veno-occlusive disease 11.5
9 idiopathic corneal edema 11.3
10 carpal tunnel syndrome 11.0
11 migraine with or without aura 1 11.0
12 lymphedema, primary, with myelodysplasia 11.0
13 hellp syndrome 11.0
14 lipodystrophy, familial partial, type 1 10.4 INS PPARG
15 hypoaldosteronism 10.3 ACE NPPA
16 complete generalized lipodystrophy 10.3 INS PPARG
17 central sleep apnea 10.3 NPPA NPPB
18 maturity-onset diabetes of the young, type 10 10.3 INS PPARG
19 vasculogenic impotence 10.3 ACE NPPA
20 autosomal dominant non-syndromic intellectual disability 2 10.3 PPARA PPARG
21 autosomal dominant non-syndromic intellectual disability 3 10.3 PPARA PPARG
22 left bundle branch hemiblock 10.3 ACE NPPB
23 lipodystrophy, familial partial, type 3 10.2 PPARA PPARG
24 anterolateral myocardial infarction 10.2 ACE NPPA NPPB
25 mitral valve stenosis 10.2 NPPA NPPB
26 chronic rhinitis 10.2 EDN1 MPO
27 diastolic heart failure 10.2 ACE NPPA NPPB
28 mitral valve insufficiency 10.2 ACE NPPA NPPB
29 acute poststreptococcal glomerulonephritis 10.2 EDN1 NPPA
30 aortic valve disease 2 10.2 ACE NPPA NPPB
31 chronic mountain sickness 10.2 EDN1 NPPB
32 alcoholic cardiomyopathy 10.2 ACE PPARA PPARG
33 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.1 ADIPOQ INS
34 ischemic heart disease 10.1 ACE NPPB
35 anuria 10.1 ACE NR3C2
36 hypersensitivity vasculitis 10.1 ACE MPO
37 hypertensive retinopathy 10.1 ACE ADIPOQ
38 lipodystrophy, congenital generalized, type 1 10.1 ADIPOQ INS
39 rere-related disorders 10.1
40 nonalcoholic steatohepatitis 10.1 ADIPOQ INS
41 aortic coarctation 10.1 ACE EDN1
42 hypertensive heart disease 10.1 ACE NPPB NR3C2
43 syncope 10.1 NPPA NPPB
44 abdominal obesity-metabolic syndrome 1 10.0 ADIPOQ INS PPARG
45 angina pectoris 10.0 ACE EDN1 NPPB
46 prediabetes syndrome 10.0 ADIPOQ INS PPARG
47 acquired generalized lipodystrophy 10.0 ADIPOQ INS PPARG
48 acanthosis nigricans 10.0 ADIPOQ INS PPARG
49 atrial fibrillation 10.0 ACE NPPA NPPB
50 morbid obesity 10.0 ADIPOQ INS PPARG

Graphical network of the top 20 diseases related to Idiopathic Edema:



Diseases related to Idiopathic Edema

Symptoms & Phenotypes for Idiopathic Edema

UMLS symptoms related to Idiopathic Edema:


edema

MGI Mouse Phenotypes related to Idiopathic Edema:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 ACE ADIPOQ ADM AQP1 EDN1 INS
2 homeostasis/metabolism MP:0005376 10.1 ACE ADIPOQ ADM AQP1 AQP2 EDN1
3 hematopoietic system MP:0005397 10.07 ACE ADIPOQ ADM AQP1 AQP2 INS
4 growth/size/body region MP:0005378 10.06 ACE ADIPOQ AQP1 AQP2 EDN1 INS
5 endocrine/exocrine gland MP:0005379 9.98 ACE ADIPOQ ADM AQP1 EDN1 INS
6 mortality/aging MP:0010768 9.9 ACE ADIPOQ ADM AQP1 AQP2 EDN1
7 adipose tissue MP:0005375 9.88 ACE ADIPOQ INS PPARA PPARG
8 liver/biliary system MP:0005370 9.73 ACE ADIPOQ ADM INS PPARA PPARG
9 muscle MP:0005369 9.61 ADIPOQ ADM EDN1 INS MPO NPPA
10 renal/urinary system MP:0005367 9.32 ACE ADIPOQ ADM AQP1 AQP2 EDN1

Drugs & Therapeutics for Idiopathic Edema

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Idiopathic Edema Completed NCT01681927

Search NIH Clinical Center for Idiopathic Edema

Genetic Tests for Idiopathic Edema

Anatomical Context for Idiopathic Edema

MalaCards organs/tissues related to Idiopathic Edema:

42
Kidney, Liver, Heart, Testes, Thyroid

Publications for Idiopathic Edema

Articles related to Idiopathic Edema:

(show top 50) (show all 83)
# Title Authors Year
1
Acute scrotal idiopathic edema: A misleading erythema. ( 28625172 )
2017
2
Clinical Characteristics of Overhydration in Patients with Idiopathic Edema. ( 27222015 )
2016
3
The confounding effect of the development of idiopathic orthostatic edema and thyrotoxcosis on weight fluctuation related to effects on free water clearance in a woman with long-standing surgically induced panhypopituitarism and diabetes insipidus. ( 26152015 )
2015
4
[The analysis of selected biochemical parameters concentration in pregnant women with idiopathic edema of the lower limbs--preliminary report]. ( 23342893 )
2012
5
Non-surgical periodontal therapy improves serum levels of C-reactive protein and edematous states in female patients with idiopathic edema. ( 20681817 )
2011
6
Idiopathic edema, a condition associated with pelvic pain and other symptoms in women, as a remedial cause of chronic cold induced urticaria. ( 21077535 )
2010
7
The treatment of idiopathic edema, a cause of chronic pelvic pain in women: effectively controlled chronic refractory urticaria--case reports. ( 17089586 )
2006
8
Idiopathic edema is associated with obstructive sleep apnea in women. ( 15511705 )
2004
9
Hormonal insights into the pathogenesis of cyclic idiopathic edema. ( 11320488 )
2001
10
Idiopathic edema. ( 10469850 )
1999
11
Effectiveness of human atrial natriuretic peptide administration in a patient with idiopathic edema. ( 10095189 )
1999
12
Extreme diuretic dependence in idiopathic edema: mechanisms, prevention and therapy. ( 9730576 )
1998
13
Idiopathic edema. ( 9174738 )
1997
14
Idiopathic edema. Pathogenesis, clinical features, and treatment. ( 8575408 )
1995
15
Idiopathic edema. ( 8144715 )
1994
16
Idiopathic edema. ( 7704709 )
1994
17
Idiopathic edema and eating disorders: evidence for an association. ( 8401552 )
1993
18
Ibopamine in idiopathic edema. ( 1300449 )
1992
19
Idiopathic edema. ( 1546886 )
1992
20
Water loading tests both in supine and upright positions in three cases of idiopathic edema. ( 1838803 )
1991
21
Idiopathic edema. ( 1959905 )
1991
22
Dopaminergic activity and idiopathic edema. ( 1801766 )
1991
23
Effect of posture on plasma atrial natriuretic hormone and renal function during salt loading in patients with and without postural (idiopathic) edema. ( 2142493 )
1990
24
Treatment of idiopathic edema with decoction of radix Aucklandiae for promoting flow of QI--analysis of 50 cases. ( 2391991 )
1990
25
Resolution of atypical chest pain during treatment for idiopathic orthostatic edema. ( 2337072 )
1990
26
Trial to differentiate idiopathic edema by plasma volume changes. ( 3172561 )
1988
27
Responses of plasma immunoreactive atrial natriuretic factor, aldosterone and urinary dopamine to salt-loading in a patient with severe idiopathic edema. ( 2951314 )
1987
28
Hormonal correlates of the inadequate natriuretic response to salt loading in idiopathic edema. ( 3555912 )
1987
29
Plasma prolactin levels in full-term newborn infants with idiopathic edema: response to furosemide. ( 3947689 )
1986
30
Idiopathic edema in the athletic woman. ( 3764465 )
1986
31
Idiopathic edema. ( 3751252 )
1986
32
Idiopathic edema: 'overlooked' causes. ( 3081532 )
1986
33
Effect of the angiotensin converting enzyme inhibitor, captopril (SQ14,225), on orthostatic sodium and water retention in patients with idiopathic edema. ( 2983253 )
1985
34
Idiopathic edema. A clinical conundrum. ( 3934201 )
1985
35
Therapeutic response of idiopathic edema to captopril. ( 6382037 )
1984
36
The effects of postural changes on ADH release and the renal handling of sodium and water in patient with idiopathic edema. ( 6519027 )
1984
37
Bromocriptine-responsive idiopathic edema. ( 6539318 )
1984
38
Altered dopaminergic modulation of sympathetic nervous system activity in idiopathic edema. ( 6512181 )
1984
39
Idiopathic edema in a male. ( 6465190 )
1984
40
Long-term furosemide treatment in idiopathic edema. ( 6497517 )
1984
41
Captopril in idiopathic edema. ( 6339935 )
1983
42
Therapeutic response of idiopathic edema to captopril. ( 6348569 )
1983
43
Intermittent fluid retention in women. Is it idiopathic edema? ( 6856543 )
1983
44
A case of familial renal hypouricemia associated with increased secretion of para-aminohippurate and idiopathic edema. ( 7099326 )
1982
45
Altered dopaminergic modulation of 18-hydroxycorticosterone secretion in idiopathic edema: therapeutic effects of bromocriptine. ( 7050141 )
1982
46
Effects of bromocriptine on renin, aldosterone, and prolactin responses to posture and metoclopramide in idiopathic edema: possible therapeutic approach. ( 7035482 )
1982
47
Idiopathic edema: role of diuretic abuse. ( 7265641 )
1981
48
Idiopathic edema treated with captopril. ( 7036013 )
1981
49
Significance of stepwise excretion pattern in renogram: indicator of the edema in patients with chronic thyroiditis and idiopathic edema. ( 7277877 )
1981
50
Role of endocrinological factors in the pathogenesis of idiopathic edema. ( 6989020 )
1980

Variations for Idiopathic Edema

Expression for Idiopathic Edema

Search GEO for disease gene expression data for Idiopathic Edema.

Pathways for Idiopathic Edema

GO Terms for Idiopathic Edema

Cellular components related to Idiopathic Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ACE ADIPOQ ADM EDN1 IL11 INS
2 extracellular space GO:0005615 9.28 ACE ADIPOQ ADM EDN1 IL11 INS

Biological processes related to Idiopathic Edema according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 ADIPOQ AQP1 EDN1 PPARG
2 heart development GO:0007507 9.88 ADM EDN1 PPARA PPARG
3 response to lipopolysaccharide GO:0032496 9.85 ADM EDN1 MPO
4 negative regulation of cell growth GO:0030308 9.83 NPPA NPPB PPARG
5 glucose homeostasis GO:0042593 9.81 ADIPOQ INS PPARG
6 transcription initiation from RNA polymerase II promoter GO:0006367 9.81 NPPA NR3C2 PPARA PPARG
7 response to insulin GO:0032868 9.76 ADM NPPA PPARA
8 steroid hormone mediated signaling pathway GO:0043401 9.7 NR3C2 PPARA PPARG
9 negative regulation of blood pressure GO:0045776 9.69 ADIPOQ PPARA
10 cellular response to copper ion GO:0071280 9.68 AQP1 AQP2
11 positive regulation of mitotic nuclear division GO:0045840 9.68 EDN1 INS
12 positive regulation of blood vessel diameter GO:0097755 9.68 ADM INS
13 response to lipid GO:0033993 9.67 PPARA PPARG
14 regulation of vasoconstriction GO:0019229 9.67 ACE EDN1
15 cGMP-mediated signaling GO:0019934 9.67 AQP1 NPPA
16 water transport GO:0006833 9.66 AQP1 AQP2
17 positive regulation of cellular protein metabolic process GO:0032270 9.66 ADIPOQ INS
18 fatty acid oxidation GO:0019395 9.65 ADIPOQ PPARG
19 response to muscle stretch GO:0035994 9.65 EDN1 NPPA
20 negative regulation of gluconeogenesis GO:0045721 9.64 ADIPOQ INS
21 positive regulation of renal sodium excretion GO:0035815 9.63 EDN1 NPPB
22 positive regulation of urine volume GO:0035810 9.63 EDN1 NPPB
23 regulation of blood vessel diameter GO:0097746 9.62 ACE NPPB
24 cGMP biosynthetic process GO:0006182 9.61 NPPA NPPB
25 receptor guanylyl cyclase signaling pathway GO:0007168 9.61 NPPA NPPB
26 body fluid secretion GO:0007589 9.6 EDN1 NPPB
27 negative regulation of cholesterol storage GO:0010887 9.59 PPARA PPARG
28 positive regulation of heart rate GO:0010460 9.58 ADM EDN1 NPPA
29 glycerol transport GO:0015793 9.57 AQP1 AQP2
30 negative regulation of acute inflammatory response GO:0002674 9.56 INS PPARG
31 positive regulation of fatty acid oxidation GO:0046321 9.55 PPARA PPARG
32 response to hypoxia GO:0001666 9.55 ADIPOQ ADM EDN1 NPPA PPARA
33 negative regulation of sequestering of triglyceride GO:0010891 9.54 PPARA PPARG
34 regulation of blood vessel size GO:0050880 9.54 EDN1 NPPA NPPB
35 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.5 ADIPOQ PPARA PPARG
36 regulation of signaling receptor activity GO:0010469 9.5 ADIPOQ ADM EDN1 IL11 INS NPPA
37 negative regulation of receptor biosynthetic process GO:0010871 9.49 PPARA PPARG
38 nitric oxide transport GO:0030185 9.48 AQP1 EDN1
39 cellular response to mercury ion GO:0071288 9.46 AQP1 AQP2
40 renal water transport GO:0003097 9.43 AQP1 AQP2
41 negative regulation of hormone secretion GO:0046888 9.43 ADIPOQ EDN1 IL11
42 regulation of blood pressure GO:0008217 9.02 ACE EDN1 NPPA NPPB PPARG

Molecular functions related to Idiopathic Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.58 ACE PPARA PPARG
2 signaling receptor binding GO:0005102 9.55 ADIPOQ ADM EDN1 NPPA NPPB
3 channel activity GO:0015267 9.48 AQP1 AQP2
4 fatty acid binding GO:0005504 9.46 PPARA PPARG
5 water channel activity GO:0015250 9.43 AQP1 AQP2
6 steroid hormone receptor activity GO:0003707 9.43 NR3C2 PPARA PPARG
7 water transmembrane transporter activity GO:0005372 9.37 AQP1 AQP2
8 hormone receptor binding GO:0051427 9.32 NPPA NPPB
9 hormone activity GO:0005179 9.1 ADIPOQ ADM EDN1 INS NPPA NPPB
10 glycerol transmembrane transporter activity GO:0015168 8.96 AQP1 AQP2

Sources for Idiopathic Edema

3 CDC
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9 Cosmic
10 dbSNP
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17 EFO
18 ExPASy
20 FMA
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31 HGMD
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