Aliases & Classifications for Idiopathic Edema

MalaCards integrated aliases for Idiopathic Edema:

Name: Idiopathic Edema 53 73
Idiopathic Orthostatic Edema 53
Fluid Retention Syndrome 53
Idiopathic Cyclic Edema 53
Body Fluid Retention 73
Edema Idiopathic 55
Fluid Retention 55
Cyclical Edema 53

Classifications:



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Summaries for Idiopathic Edema

NIH Rare Diseases : 53 Idiopathic edema is a common cause of fluid retention and swelling (edema) in women. "Idiopathic" means that the cause of this condition is unknown. Idiopathic edema occurs in the absence of heart, kidney, or liver disease. It is often associated with diabetes, obesity, and emotional problems. The edema may develop periodically or it may persist over time. Swelling of the face, hands, and legs can develop rapidly, and affected individuals typically experience significant changes in their weight over the course of a day. Treatment often includes a low sodium and carbohydrate diet as well as cessation of diuretic therapy (if warranted).

MalaCards based summary : Idiopathic Edema, also known as idiopathic orthostatic edema, is related to apnea, obstructive sleep and sleep apnea, and has symptoms including edema An important gene associated with Idiopathic Edema is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are Glucose / Energy Metabolism and MicroRNAs in cardiomyocyte hypertrophy. Affiliated tissues include heart, liver and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Idiopathic Edema

Diseases related to Idiopathic Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 29.0 ADIPOQ EDN1 INS
2 sleep apnea 27.9 ACE ADIPOQ EDN1 INS NPPB
3 diabetes mellitus, noninsulin-dependent 27.3 ACE ADIPOQ EDN1 INS PPARA PPARG
4 diabetes mellitus 27.3 ACE ADIPOQ EDN1 INS PPARA PPARG
5 congestive heart failure 25.9 ACE ADM AQP2 EDN1 NPPA NPPB
6 idiopathic corneal edema 11.1
7 hepatic veno-occlusive disease 11.0
8 carpal tunnel syndrome 10.9
9 migraine with or without aura 1 10.9
10 lymphedema 10.9
11 hellp syndrome 10.9
12 postural hypotension 10.8 INS NPPA
13 hypoaldosteronism 10.7 ACE NPPA
14 renal artery disease 10.7 ACE NPPA
15 central sleep apnea 10.7 NPPA NPPB
16 hypertension, diastolic 10.7 ACE NPPA
17 vasculogenic impotence 10.6 ACE NPPA
18 mitral valve stenosis 10.5 NPPA NPPB
19 chronic rhinitis 10.4 EDN1 MPO
20 chronic thromboembolic pulmonary hypertension 10.4 EDN1 NPPB
21 mitral valve insufficiency 10.4 ACE NPPA NPPB
22 ischemic heart disease 10.4 ACE INS NPPB
23 aortic valve disease 2 10.4 ACE NPPA NPPB
24 acute poststreptococcal glomerulonephritis 10.4 EDN1 NPPA
25 alcoholic cardiomyopathy 10.3 ACE PPARA PPARG
26 aortic valve insufficiency 10.3 ACE NPPB
27 chronic mountain sickness 10.3 EDN1 NPPB
28 anuria 10.3 ACE NR3C2
29 diastolic heart failure 10.3 ACE NPPB
30 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.3 ADIPOQ INS
31 hypertensive retinopathy 10.3 ACE ADIPOQ
32 angina pectoris 10.3 ACE EDN1
33 nonalcoholic steatohepatitis 10.2 ADIPOQ INS
34 systolic heart failure 10.2 ACE NPPB NR3C2
35 aortic coarctation 10.2 ACE EDN1
36 hypertensive heart disease 10.2 ACE NPPB NR3C2
37 abdominal obesity-metabolic syndrome 1 10.1 ADIPOQ INS PPARG
38 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 ADIPOQ MPO PPARG
39 pulmonary edema 10.1 ACE EDN1 NPPB
40 prediabetes syndrome 10.1 ADIPOQ INS PPARG
41 acanthosis nigricans 10.1 ADIPOQ INS PPARG
42 cerebrovascular disease 10.1 ACE ADM INS
43 overnutrition 10.0 ADIPOQ INS PPARG
44 morbid obesity 10.0 ADIPOQ INS PPARG
45 atherosclerosis susceptibility 10.0 ADIPOQ INS PPARG
46 lung disease 10.0 EDN1 MPO NPPB
47 coronary heart disease 1 10.0 ACE ADIPOQ INS
48 hyperglycemia 10.0 ADIPOQ INS PPARG
49 syncope 9.9 NPPA NPPB
50 inappropriate adh syndrome 9.9 AQP1 AQP2

Graphical network of the top 20 diseases related to Idiopathic Edema:



Diseases related to Idiopathic Edema

Symptoms & Phenotypes for Idiopathic Edema

UMLS symptoms related to Idiopathic Edema:


edema

MGI Mouse Phenotypes related to Idiopathic Edema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 INS ADM MPO AQP1 ACE ADIPOQ
2 homeostasis/metabolism MP:0005376 10.1 INS ADM MPO AQP1 ACE AQP2
3 hematopoietic system MP:0005397 10.07 INS ADM AQP1 ACE AQP2 ADIPOQ
4 growth/size/body region MP:0005378 10.06 EDN1 ADIPOQ INS AQP1 ACE AQP2
5 endocrine/exocrine gland MP:0005379 9.98 EDN1 ADIPOQ INS ADM AQP1 ACE
6 mortality/aging MP:0010768 9.9 EDN1 ADIPOQ INS ADM AQP1 ACE
7 liver/biliary system MP:0005370 9.73 ADIPOQ INS ADM ACE PPARA PPARG
8 muscle MP:0005369 9.61 INS ADM MPO ADIPOQ EDN1 PPARA
9 renal/urinary system MP:0005367 9.32 INS ADM AQP1 ACE AQP2 ADIPOQ

Drugs & Therapeutics for Idiopathic Edema

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Idiopathic Edema Completed NCT01681927

Search NIH Clinical Center for Idiopathic Edema

Genetic Tests for Idiopathic Edema

Anatomical Context for Idiopathic Edema

MalaCards organs/tissues related to Idiopathic Edema:

41
Heart, Liver, Kidney, Testes, Thyroid

Publications for Idiopathic Edema

Articles related to Idiopathic Edema:

(show top 50) (show all 78)
# Title Authors Year
1
Acute scrotal idiopathic edema: A misleading erythema. ( 28625172 )
2017
2
Clinical Characteristics of Overhydration in Patients with Idiopathic Edema. ( 27222015 )
2016
3
[The analysis of selected biochemical parameters concentration in pregnant women with idiopathic edema of the lower limbs--preliminary report]. ( 23342893 )
2012
4
Non-surgical periodontal therapy improves serum levels of C-reactive protein and edematous states in female patients with idiopathic edema. ( 20681817 )
2011
5
Idiopathic edema, a condition associated with pelvic pain and other symptoms in women, as a remedial cause of chronic cold induced urticaria. ( 21077535 )
2010
6
The treatment of idiopathic edema, a cause of chronic pelvic pain in women: effectively controlled chronic refractory urticaria--case reports. ( 17089586 )
2006
7
Idiopathic edema is associated with obstructive sleep apnea in women. ( 15511705 )
2004
8
Hormonal insights into the pathogenesis of cyclic idiopathic edema. ( 11320488 )
2001
9
Idiopathic edema. ( 10469850 )
1999
10
Effectiveness of human atrial natriuretic peptide administration in a patient with idiopathic edema. ( 10095189 )
1999
11
Extreme diuretic dependence in idiopathic edema: mechanisms, prevention and therapy. ( 9730576 )
1998
12
Idiopathic edema. ( 9174738 )
1997
13
Idiopathic edema. Pathogenesis, clinical features, and treatment. ( 8575408 )
1995
14
Idiopathic edema. ( 8144715 )
1994
15
Idiopathic edema. ( 7704709 )
1994
16
Idiopathic edema and eating disorders: evidence for an association. ( 8401552 )
1993
17
Ibopamine in idiopathic edema. ( 1300449 )
1992
18
Idiopathic edema. ( 1546886 )
1992
19
Water loading tests both in supine and upright positions in three cases of idiopathic edema. ( 1838803 )
1991
20
Idiopathic edema. ( 1959905 )
1991
21
Dopaminergic activity and idiopathic edema. ( 1801766 )
1991
22
Effect of posture on plasma atrial natriuretic hormone and renal function during salt loading in patients with and without postural (idiopathic) edema. ( 2142493 )
1990
23
Treatment of idiopathic edema with decoction of radix Aucklandiae for promoting flow of QI--analysis of 50 cases. ( 2391991 )
1990
24
Trial to differentiate idiopathic edema by plasma volume changes. ( 3172561 )
1988
25
Responses of plasma immunoreactive atrial natriuretic factor, aldosterone and urinary dopamine to salt-loading in a patient with severe idiopathic edema. ( 2951314 )
1987
26
Hormonal correlates of the inadequate natriuretic response to salt loading in idiopathic edema. ( 3555912 )
1987
27
Plasma prolactin levels in full-term newborn infants with idiopathic edema: response to furosemide. ( 3947689 )
1986
28
Idiopathic edema in the athletic woman. ( 3764465 )
1986
29
Idiopathic edema. ( 3751252 )
1986
30
Effect of the angiotensin converting enzyme inhibitor, captopril (SQ14,225), on orthostatic sodium and water retention in patients with idiopathic edema. ( 2983253 )
1985
31
Idiopathic edema. A clinical conundrum. ( 3934201 )
1985
32
Therapeutic response of idiopathic edema to captopril. ( 6382037 )
1984
33
The effects of postural changes on ADH release and the renal handling of sodium and water in patient with idiopathic edema. ( 6519027 )
1984
34
Bromocriptine-responsive idiopathic edema. ( 6539318 )
1984
35
Altered dopaminergic modulation of sympathetic nervous system activity in idiopathic edema. ( 6512181 )
1984
36
Idiopathic edema in a male. ( 6465190 )
1984
37
Long-term furosemide treatment in idiopathic edema. ( 6497517 )
1984
38
Captopril in idiopathic edema. ( 6339935 )
1983
39
Therapeutic response of idiopathic edema to captopril. ( 6348569 )
1983
40
Intermittent fluid retention in women. Is it idiopathic edema? ( 6856543 )
1983
41
A case of familial renal hypouricemia associated with increased secretion of para-aminohippurate and idiopathic edema. ( 7099326 )
1982
42
Altered dopaminergic modulation of 18-hydroxycorticosterone secretion in idiopathic edema: therapeutic effects of bromocriptine. ( 7050141 )
1982
43
Effects of bromocriptine on renin, aldosterone, and prolactin responses to posture and metoclopramide in idiopathic edema: possible therapeutic approach. ( 7035482 )
1982
44
Idiopathic edema: role of diuretic abuse. ( 7265641 )
1981
45
Idiopathic edema treated with captopril. ( 7036013 )
1981
46
Significance of stepwise excretion pattern in renogram: indicator of the edema in patients with chronic thyroiditis and idiopathic edema. ( 7277877 )
1981
47
Role of endocrinological factors in the pathogenesis of idiopathic edema. ( 6989020 )
1980
48
Idiopathic edema. ( 7002454 )
1980
49
Idiopathic edema. ( 86011 )
1979
50
Idiopathic edema as a cause of nonarticular rheumatism. ( 311641 )
1979

Variations for Idiopathic Edema

Expression for Idiopathic Edema

Search GEO for disease gene expression data for Idiopathic Edema.

Pathways for Idiopathic Edema

GO Terms for Idiopathic Edema

Cellular components related to Idiopathic Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ACE ADIPOQ ADM EDN1 IL11 INS
2 extracellular space GO:0005615 9.28 ACE ADIPOQ ADM EDN1 IL11 INS

Biological processes related to Idiopathic Edema according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.93 ADIPOQ AQP1 EDN1 PPARG
2 heart development GO:0007507 9.91 ADM EDN1 PPARA PPARG
3 negative regulation of cell growth GO:0030308 9.85 NPPA NPPB PPARG
4 transcription initiation from RNA polymerase II promoter GO:0006367 9.85 NPPA NR3C2 PPARA PPARG
5 negative regulation of inflammatory response GO:0050728 9.83 ADIPOQ PPARA PPARG
6 glucose homeostasis GO:0042593 9.82 ADIPOQ INS PPARG
7 response to organic substance GO:0010033 9.81 ADM INS PPARG
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 ADIPOQ IL11 INS
9 response to nutrient levels GO:0031667 9.76 ADIPOQ INS PPARA
10 steroid hormone mediated signaling pathway GO:0043401 9.74 NR3C2 PPARA PPARG
11 response to lipid GO:0033993 9.7 PPARA PPARG
12 positive regulation of mitotic nuclear division GO:0045840 9.69 EDN1 INS
13 cellular response to copper ion GO:0071280 9.69 AQP1 AQP2
14 positive regulation of blood vessel diameter GO:0097755 9.69 ADM INS
15 membrane depolarization GO:0051899 9.68 ADIPOQ EDN1
16 regulation of vasoconstriction GO:0019229 9.68 ACE EDN1
17 water transport GO:0006833 9.68 AQP1 AQP2
18 positive regulation of cellular protein metabolic process GO:0032270 9.68 ADIPOQ INS
19 response to muscle stretch GO:0035994 9.67 EDN1 NPPA
20 fatty acid oxidation GO:0019395 9.67 ADIPOQ PPARG
21 response to insulin GO:0032868 9.67 ADM INS NPPA PPARA
22 positive regulation of renal sodium excretion GO:0035815 9.66 EDN1 NPPB
23 regulation of blood vessel diameter GO:0097746 9.65 ACE NPPB
24 positive regulation of urine volume GO:0035810 9.65 EDN1 NPPB
25 response to hypoxia GO:0001666 9.65 ADIPOQ ADM EDN1 NPPA PPARA
26 negative regulation of gluconeogenesis GO:0045721 9.64 ADIPOQ INS
27 cGMP biosynthetic process GO:0006182 9.63 AQP1 NPPA NPPB
28 receptor guanylyl cyclase signaling pathway GO:0007168 9.62 NPPA NPPB
29 body fluid secretion GO:0007589 9.62 EDN1 NPPB
30 glycerol transport GO:0015793 9.61 AQP1 AQP2
31 positive regulation of heart rate GO:0010460 9.61 ADM EDN1 NPPA
32 negative regulation of acute inflammatory response GO:0002674 9.6 INS PPARG
33 positive regulation of fatty acid oxidation GO:0046321 9.59 PPARA PPARG
34 negative regulation of cholesterol storage GO:0010887 9.58 PPARA PPARG
35 regulation of blood vessel size GO:0050880 9.58 EDN1 NPPA NPPB
36 negative regulation of sequestering of triglyceride GO:0010891 9.56 PPARA PPARG
37 nitric oxide transport GO:0030185 9.54 AQP1 EDN1
38 negative regulation of receptor biosynthetic process GO:0010871 9.52 PPARA PPARG
39 positive regulation of fatty acid metabolic process GO:0045923 9.51 ADIPOQ PPARA
40 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.5 ADIPOQ PPARA PPARG
41 regulation of signaling receptor activity GO:0010469 9.5 ADIPOQ ADM EDN1 IL11 INS NPPA
42 cellular response to mercury ion GO:0071288 9.49 AQP1 AQP2
43 renal water transport GO:0003097 9.48 AQP1 AQP2
44 negative regulation of hormone secretion GO:0046888 9.33 ADIPOQ EDN1 IL11
45 regulation of blood pressure GO:0008217 9.02 ACE EDN1 NPPA NPPB PPARG

Molecular functions related to Idiopathic Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.58 ACE PPARA PPARG
2 signaling receptor binding GO:0005102 9.55 ADIPOQ ADM EDN1 NPPA NPPB
3 steroid hormone receptor activity GO:0003707 9.5 NR3C2 PPARA PPARG
4 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.46 PPARA PPARG
5 water channel activity GO:0015250 9.43 AQP1 AQP2
6 water transmembrane transporter activity GO:0005372 9.37 AQP1 AQP2
7 hormone receptor binding GO:0051427 9.26 NPPA NPPB
8 hormone activity GO:0005179 9.1 ADIPOQ ADM EDN1 INS NPPA NPPB
9 glycerol transmembrane transporter activity GO:0015168 8.96 AQP1 AQP2

Sources for Idiopathic Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
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45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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