MCID: IDP090
MIFTS: 26

Idiopathic Eosinophilic Pneumonia

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Idiopathic Eosinophilic Pneumonia

MalaCards integrated aliases for Idiopathic Eosinophilic Pneumonia:

Name: Idiopathic Eosinophilic Pneumonia 58

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

ICD10 via Orphanet 33 J82
Orphanet 58 ORPHA182101

Summaries for Idiopathic Eosinophilic Pneumonia

MalaCards based summary : Idiopathic Eosinophilic Pneumonia is related to pneumonia and chronic eosinophilic pneumonia. An important gene associated with Idiopathic Eosinophilic Pneumonia is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. Related phenotypes are cellular and hematopoietic system

Related Diseases for Idiopathic Eosinophilic Pneumonia

Diseases in the Idiopathic Eosinophilic Pneumonia family:

Idiopathic Acute Eosinophilic Pneumonia

Diseases related to Idiopathic Eosinophilic Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 pneumonia 29.9 SELL ITGAM ITGA4
2 chronic eosinophilic pneumonia 11.3
3 eosinophilic pneumonia 10.4
4 lung disease 10.2
5 hypereosinophilic syndrome 10.1
6 venous insufficiency 10.1 SELL ITGA4
7 actinic prurigo 10.0 ITGAL ITGA4
8 polyarteritis nodosa 10.0 SELL ITGA4
9 pulmonary fibrosis, idiopathic 9.9
10 sarcoidosis 1 9.9
11 dermatitis, atopic 9.9
12 idiopathic interstitial pneumonia 9.9
13 interstitial lung disease 9.9
14 pulmonary fibrosis 9.9
15 idiopathic acute eosinophilic pneumonia 9.9
16 extrinsic allergic alveolitis 9.9 SELL ITGAL
17 listeriosis 9.9 SELL ITGAM
18 spondyloarthropathy 9.9 SELL ITGAL
19 brachydactyly, type c 9.9 SELL ITGAM
20 hypotrichosis 1 9.9 SELL ITGAM
21 lymphopenia 9.9 SELL ITGAL
22 coronary restenosis 9.9 ITGB2 ITGA4
23 primary bacterial infectious disease 9.8 SELL ITGAM
24 pustulosis palmaris et plantaris 9.8 ITGB2 ITGAL
25 actinobacillosis 9.8 ITGB2 ITGAL
26 membranoproliferative glomerulonephritis 9.8 ITGB2 ITGAL
27 primary progressive multiple sclerosis 9.8 SELL ITGAL ITGA4
28 common variable immunodeficiency 9.7 SELL ITGAM ITGA4
29 peritonitis 9.7 ITGB2 ITGAM
30 human immunodeficiency virus infectious disease 9.6 SELL ITGAL
31 leishmaniasis 9.6 ITGB2 ITGAM
32 multiple sclerosis 9.6 ITGB2 ITGAL ITGA4
33 pertussis 9.6 ITGB2 ITGAM
34 allergic asthma 9.5 ITGB2 ITGAM
35 granulocytopenia 9.5 SELL ITGB2 ITGAM
36 skin disease 9.5 SELL ITGB2 ITGAL
37 bacterial infectious disease 9.5 SELL ITGB2 ITGAM
38 psoriasis 9.5 ITGB2 ITGAL ITGA4
39 chronic venous insufficiency 9.4 SELL ITGAM ITGAL ITGA4
40 acute promyelocytic leukemia 9.4 ITGB2 ITGAM ITGAL
41 lymphoma, non-hodgkin, familial 9.4 SELL ITGAM ITGAL ITGA4
42 leukemia, acute lymphoblastic 9.4 SELL ITGAM ITGAL ITGA4
43 leukemia, chronic lymphocytic 9.3 SELL ITGB2 ITGAL ITGA4
44 vasculitis 9.3 SELL ITGB2 ITGAM ITGA4
45 combined immunodeficiency 9.2 SELL ITGB2 ITGAM ITGAL
46 immune deficiency disease 9.2 SELL ITGB2 ITGAM ITGAL
47 thrombocytopenia 9.2 SELL ITGB2 ITGAM ITGAL
48 systemic lupus erythematosus 9.2 SELL ITGB2 ITGAM ITGAL
49 leukocyte adhesion deficiency, type i 9.0 SELL ITGB2 ITGAM ITGAL ITGA4
50 inflammatory bowel disease 9.0 SELL ITGB2 ITGAM ITGAL ITGA4

Graphical network of the top 20 diseases related to Idiopathic Eosinophilic Pneumonia:



Diseases related to Idiopathic Eosinophilic Pneumonia

Symptoms & Phenotypes for Idiopathic Eosinophilic Pneumonia

MGI Mouse Phenotypes related to Idiopathic Eosinophilic Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 ITGA4 ITGAL ITGAM ITGB2 SELL
2 hematopoietic system MP:0005397 9.35 ITGA4 ITGAL ITGAM ITGB2 SELL
3 immune system MP:0005387 9.02 ITGA4 ITGAL ITGAM ITGB2 SELL

Drugs & Therapeutics for Idiopathic Eosinophilic Pneumonia

Search Clinical Trials , NIH Clinical Center for Idiopathic Eosinophilic Pneumonia

Genetic Tests for Idiopathic Eosinophilic Pneumonia

Anatomical Context for Idiopathic Eosinophilic Pneumonia

Publications for Idiopathic Eosinophilic Pneumonia

Articles related to Idiopathic Eosinophilic Pneumonia:

(show all 24)
# Title Authors PMID Year
1
Elevated levels of periostin and TGF-β1 in the bronchoalveolar lavage fluid of patients with idiopathic eosinophilic pneumonia. 61
31012597 2020
2
[Acute idiopathic eosinophilic pneumonia in a teenager]. 61
30188028 2018
3
Flow cytometry applications in the study of immunological lung disorders. 61
25530134 2015
4
Idiopathic eosinophilic pneumonia in children: the French experience. 61
24555756 2014
5
Idiopathic chronic eosinophilic pneumonia in 7 horses. 61
18466259 2008
6
[Clinicopathological differences between acute and chronic eosinophilic pneumonia]. 61
17419433 2007
7
Elevated soluble ADAM8 in bronchoalveolar lavage fluid in patients with eosinophilic pneumonia. 61
17124430 2007
8
Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages. 61
15751278 2005
9
Clinicopathological differences between acute and chronic eosinophilic pneumonia. 61
15691242 2005
10
Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor. 61
12948934 2004
11
[Orphan lung diseases: from curiosity to concern]. 61
15656236 2004
12
[Clinical case of the month. Chronic eosinophilic pneumonia]. 61
14626647 2003
13
Fatal idiopathic acute eosinophilic pneumonia with acute lung injury. 61
12421248 2002
14
Recurrent post-partum pulmonary eosinophilia. 61
9516905 1997
15
Adhesion molecule expression on eosinophils in idiopathic eosinophilic pneumonia. 61
8980959 1996
16
Activated and memory alveolar T-lymphocytes in idiopathic eosinophilic pneumonia. 61
7489791 1995
17
Idiopathic eosinophilic pneumonia and pregnancy: report of a case. 61
7819748 1995
18
[Subacute idiopathic eosinophilic pneumopathy with favorable outcome without corticotherapy]. 61
7899663 1995
19
A clinical study of idiopathic eosinophilic pneumonia. 61
8181338 1994
20
[Pulmonary eosinophilia]. 61
8492456 1993
21
[A case of eosinophilic pneumonia with diffuse reticular shadows and scattered nodular shadows on chest X-ray film--comparison of findings of chest X-ray and lung histology]. 61
1289640 1992
22
[Idiopathic subacute pulmonary eosinophilia]. 61
1439096 1992
23
Diagnostic significance of increased bronchoalveolar lavage fluid eosinophils. 61
2389917 1990
24
[Hypereosinophilia in bronchoalveolar lavage. Diagnostic value and correlations with blood eosinophilia]. 61
3432714 1987

Variations for Idiopathic Eosinophilic Pneumonia

Expression for Idiopathic Eosinophilic Pneumonia

Search GEO for disease gene expression data for Idiopathic Eosinophilic Pneumonia.

Pathways for Idiopathic Eosinophilic Pneumonia

Pathways related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 SELL ITGB2 ITGAM ITGAL ITGA4
2
Show member pathways
13.38 ITGB2 ITGAM ITGAL ITGA4
3
Show member pathways
13.24 ITGB2 ITGAM ITGAL ITGA4
4
Show member pathways
13.16 SELL ITGB2 ITGAL ITGA4
5
Show member pathways
13.12 ITGB2 ITGAM ITGAL ITGA4
6
Show member pathways
13.12 ITGB2 ITGAM ITGAL ITGA4
7
Show member pathways
13.03 SELL ITGB2 ITGAM ITGAL ITGA4
8
Show member pathways
12.85 ITGB2 ITGAM ITGAL ITGA4
9
Show member pathways
12.75 ITGB2 ITGAM ITGAL ITGA4
10
Show member pathways
12.73 ITGB2 ITGAM ITGAL ITGA4
11
Show member pathways
12.71 ITGB2 ITGAM ITGAL ITGA4
12
Show member pathways
12.67 ITGB2 ITGAM ITGAL ITGA4
13
Show member pathways
12.61 ITGB2 ITGAL ITGA4
14
Show member pathways
12.61 ITGB2 ITGAM ITGAL ITGA4
15
Show member pathways
12.55 ITGB2 ITGAM ITGAL ITGA4
16
Show member pathways
12.5 ITGB2 ITGAM ITGAL
17
Show member pathways
12.48 ITGB2 ITGAM ITGAL ITGA4
18
Show member pathways
12.46 ITGB2 ITGAM ITGAL ITGA4
19 12.44 ITGB2 ITGAM ITGAL ITGA4
20
Show member pathways
12.2 ITGB2 ITGAM ITGAL ITGA4
21
Show member pathways
12.1 ITGB2 ITGAM ITGA4
22 12.06 ITGB2 ITGAM ITGAL ITGA4
23
Show member pathways
12.02 ITGB2 ITGAM ITGAL ITGA4
24 12.01 ITGB2 ITGAM ITGAL ITGA4
25
Show member pathways
11.93 ITGB2 ITGAM ITGAL ITGA4
26 11.86 SELL ITGAM ITGAL
27
Show member pathways
11.82 ITGB2 ITGAM ITGAL ITGA4
28 11.8 ITGB2 ITGA4
29 11.77 ITGB2 ITGAM
30 11.76 ITGB2 ITGAM ITGAL
31 11.75 SELL ITGB2 ITGAL ITGA4
32 11.72 ITGB2 ITGAM
33 11.71 ITGB2 ITGAM ITGAL ITGA4
34 11.7 ITGAM ITGA4
35 11.67 ITGB2 ITGAL
36 11.6 ITGAM ITGA4
37
Show member pathways
11.6 SELL ITGB2 ITGAM ITGAL ITGA4
38 11.58 ITGB2 ITGAM
39 11.56 SELL ITGAM
40 11.54 ITGB2 ITGAL ITGA4
41 11.52 ITGB2 ITGAM ITGAL ITGA4
42 11.49 ITGB2 ITGAM ITGAL ITGA4
43 11.44 ITGB2 ITGAM
44 11.43 ITGAM ITGAL
45 11.36 ITGB2 ITGAL
46 11.34 ITGB2 ITGAM
47 11.34 ITGB2 ITGAM
48 11.34 ITGB2 ITGAM ITGAL ITGA4
49
Show member pathways
11.33 ITGB2 ITGAL ITGA4
50 11.19 ITGB2 ITGAL

GO Terms for Idiopathic Eosinophilic Pneumonia

Cellular components related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 ITGB2 ITGAM ITGAL ITGA4
2 cell surface GO:0009986 9.62 ITGB2 ITGAM ITGAL ITGA4
3 specific granule membrane GO:0035579 9.43 ITGB2 ITGAM ITGAL
4 tertiary granule membrane GO:0070821 9.4 ITGB2 ITGAM
5 plasma membrane raft GO:0044853 9.37 ITGB2 ITGAM
6 integrin alphaM-beta2 complex GO:0034688 9.16 ITGB2 ITGAM
7 integrin alphaL-beta2 complex GO:0034687 8.96 ITGB2 ITGAL
8 integrin complex GO:0008305 8.92 ITGB2 ITGAM ITGAL ITGA4

Biological processes related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.81 SELL ITGB2 ITGAM ITGAL
2 extracellular matrix organization GO:0030198 9.71 ITGB2 ITGAM ITGAL ITGA4
3 cell-matrix adhesion GO:0007160 9.67 ITGB2 ITGAL ITGA4
4 regulation of immune response GO:0050776 9.67 SELL ITGB2 ITGAL ITGA4
5 cell adhesion GO:0007155 9.65 SELL ITGB2 ITGAM ITGAL ITGA4
6 phagocytosis, engulfment GO:0006911 9.62 ITGB2 ITGAM
7 phagocytosis GO:0006909 9.61 ITGB2 ITGAL
8 positive regulation of neuron death GO:1901216 9.61 ITGB2 ITGAM
9 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.6 ITGB2 ITGAM
10 positive regulation of protein targeting to membrane GO:0090314 9.59 ITGB2 ITGAM
11 microglial cell activation GO:0001774 9.58 ITGB2 ITGAM
12 endodermal cell differentiation GO:0035987 9.58 ITGB2 ITGA4
13 heterotypic cell-cell adhesion GO:0034113 9.57 ITGB2 ITGA4
14 leukocyte tethering or rolling GO:0050901 9.56 SELL ITGA4
15 positive regulation of superoxide anion generation GO:0032930 9.55 ITGB2 ITGAM
16 toll-like receptor 4 signaling pathway GO:0034142 9.54 ITGB2 ITGAM
17 amyloid-beta clearance GO:0097242 9.52 ITGB2 ITGAM
18 leukocyte cell-cell adhesion GO:0007159 9.5 ITGB2 ITGAL ITGA4
19 negative regulation of dopamine metabolic process GO:0045963 9.48 ITGB2 ITGAM
20 positive regulation of neutrophil degranulation GO:0043315 9.46 ITGB2 ITGAM
21 positive regulation of prostaglandin-E synthase activity GO:2000363 9.43 ITGB2 ITGAM
22 receptor clustering GO:0043113 9.33 ITGB2 ITGAL ITGA4
23 integrin-mediated signaling pathway GO:0007229 9.26 ITGB2 ITGAM ITGAL ITGA4
24 leukocyte migration GO:0050900 9.02 SELL ITGB2 ITGAM ITGAL ITGA4

Molecular functions related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.8 SELL ITGB2 ITGAM ITGAL ITGA4
2 protein-containing complex binding GO:0044877 9.54 ITGB2 ITGAM ITGAL
3 amyloid-beta binding GO:0001540 9.46 ITGB2 ITGAM
4 heat shock protein binding GO:0031072 9.43 ITGB2 ITGAM
5 integrin binding GO:0005178 9.43 ITGB2 ITGAM ITGA4
6 cargo receptor activity GO:0038024 9.32 ITGB2 ITGAM
7 complement component C3b binding GO:0001851 9.16 ITGB2 ITGAM
8 cell adhesion molecule binding GO:0050839 9.13 ITGB2 ITGAL ITGA4
9 ICAM-3 receptor activity GO:0030369 8.62 ITGB2 ITGAL

Sources for Idiopathic Eosinophilic Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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