MCID: IDP090
MIFTS: 29

Idiopathic Eosinophilic Pneumonia

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Idiopathic Eosinophilic Pneumonia

MalaCards integrated aliases for Idiopathic Eosinophilic Pneumonia:

Name: Idiopathic Eosinophilic Pneumonia 59

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

ICD10 via Orphanet 34 J82
Orphanet 59 ORPHA182101

Summaries for Idiopathic Eosinophilic Pneumonia

MalaCards based summary : Idiopathic Eosinophilic Pneumonia is related to chronic eosinophilic pneumonia and eosinophilic pneumonia. An important gene associated with Idiopathic Eosinophilic Pneumonia is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include lung, and related phenotypes are cellular and hematopoietic system

Related Diseases for Idiopathic Eosinophilic Pneumonia

Graphical network of the top 20 diseases related to Idiopathic Eosinophilic Pneumonia:



Diseases related to Idiopathic Eosinophilic Pneumonia

Symptoms & Phenotypes for Idiopathic Eosinophilic Pneumonia

MGI Mouse Phenotypes related to Idiopathic Eosinophilic Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 ITGA4 ITGAL ITGAM ITGB2 SELL
2 hematopoietic system MP:0005397 9.35 ITGA4 ITGAL ITGAM ITGB2 SELL
3 immune system MP:0005387 9.02 ITGA4 ITGAL ITGAM ITGB2 SELL

Drugs & Therapeutics for Idiopathic Eosinophilic Pneumonia

Search Clinical Trials , NIH Clinical Center for Idiopathic Eosinophilic Pneumonia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Betamethasone
Prednisolone
Prednisone
Triamcinolone

Genetic Tests for Idiopathic Eosinophilic Pneumonia

Anatomical Context for Idiopathic Eosinophilic Pneumonia

MalaCards organs/tissues related to Idiopathic Eosinophilic Pneumonia:

41
Lung

Publications for Idiopathic Eosinophilic Pneumonia

Articles related to Idiopathic Eosinophilic Pneumonia:

(show all 24)
# Title Authors PMID Year
1
Elevated levels of periostin and TGF-β1 in the bronchoalveolar lavage fluid of patients with idiopathic eosinophilic pneumonia. 38
31012597 2019
2
[Acute idiopathic eosinophilic pneumonia in a teenager]. 38
30188028 2018
3
Flow cytometry applications in the study of immunological lung disorders. 38
25530134 2015
4
Idiopathic eosinophilic pneumonia in children: the French experience. 38
24555756 2014
5
Idiopathic chronic eosinophilic pneumonia in 7 horses. 38
18466259 2008
6
[Clinicopathological differences between acute and chronic eosinophilic pneumonia]. 38
17419433 2007
7
Elevated soluble ADAM8 in bronchoalveolar lavage fluid in patients with eosinophilic pneumonia. 38
17124430 2007
8
Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages. 38
15751278 2005
9
Clinicopathological differences between acute and chronic eosinophilic pneumonia. 38
15691242 2005
10
[Orphan lung diseases: from curiosity to concern]. 38
15656236 2004
11
Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor. 38
12948934 2004
12
[Clinical case of the month. Chronic eosinophilic pneumonia]. 38
14626647 2003
13
Fatal idiopathic acute eosinophilic pneumonia with acute lung injury. 38
12421248 2002
14
Recurrent post-partum pulmonary eosinophilia. 38
9516905 1997
15
Adhesion molecule expression on eosinophils in idiopathic eosinophilic pneumonia. 38
8980959 1996
16
Activated and memory alveolar T-lymphocytes in idiopathic eosinophilic pneumonia. 38
7489791 1995
17
Idiopathic eosinophilic pneumonia and pregnancy: report of a case. 38
7819748 1995
18
[Subacute idiopathic eosinophilic pneumopathy with favorable outcome without corticotherapy]. 38
7899663 1995
19
A clinical study of idiopathic eosinophilic pneumonia. 38
8181338 1994
20
[Pulmonary eosinophilia]. 38
8492456 1993
21
[A case of eosinophilic pneumonia with diffuse reticular shadows and scattered nodular shadows on chest X-ray film--comparison of findings of chest X-ray and lung histology]. 38
1289640 1992
22
[Idiopathic subacute pulmonary eosinophilia]. 38
1439096 1992
23
Diagnostic significance of increased bronchoalveolar lavage fluid eosinophils. 38
2389917 1990
24
[Hypereosinophilia in bronchoalveolar lavage. Diagnostic value and correlations with blood eosinophilia]. 38
3432714 1987

Variations for Idiopathic Eosinophilic Pneumonia

Expression for Idiopathic Eosinophilic Pneumonia

Search GEO for disease gene expression data for Idiopathic Eosinophilic Pneumonia.

Pathways for Idiopathic Eosinophilic Pneumonia

Pathways related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 SELL ITGB2 ITGAM ITGAL ITGA4
2
Show member pathways
13.24 ITGB2 ITGAM ITGAL ITGA4
3
Show member pathways
13.17 SELL ITGB2 ITGAL ITGA4
4
Show member pathways
13.13 ITGB2 ITGAM ITGAL ITGA4
5
Show member pathways
13.12 ITGB2 ITGAM ITGAL ITGA4
6
Show member pathways
13.07 SELL ITGB2 ITGAM ITGAL ITGA4
7
Show member pathways
12.86 ITGB2 ITGAM ITGAL ITGA4
8
Show member pathways
12.79 ITGB2 ITGAM ITGAL ITGA4
9
Show member pathways
12.74 ITGB2 ITGAM ITGAL ITGA4
10
Show member pathways
12.71 ITGB2 ITGAM ITGAL ITGA4
11
Show member pathways
12.68 ITGB2 ITGAM ITGAL ITGA4
12
Show member pathways
12.63 ITGB2 ITGAL ITGA4
13
Show member pathways
12.63 ITGB2 ITGAM ITGAL ITGA4
14
Show member pathways
12.62 ITGB2 ITGAM ITGAL ITGA4
15
Show member pathways
12.57 ITGB2 ITGAM ITGAL ITGA4
16
Show member pathways
12.51 ITGB2 ITGAM ITGAL
17
Show member pathways
12.48 ITGB2 ITGAM ITGAL ITGA4
18 12.45 ITGB2 ITGAM ITGAL ITGA4
19
Show member pathways
12.21 ITGB2 ITGAM ITGAL ITGA4
20
Show member pathways
12.11 ITGB2 ITGAM ITGA4
21
Show member pathways
12.05 ITGB2 ITGAM ITGAL ITGA4
22
Show member pathways
12.03 ITGB2 ITGAM ITGAL ITGA4
23
Show member pathways
12 ITGB2 ITGAM ITGAL ITGA4
24
Show member pathways
11.95 ITGB2 ITGAM ITGAL ITGA4
25 11.93 ITGB2 ITGAM ITGAL ITGA4
26 11.87 ITGB2 ITGAM
27 11.87 SELL ITGAM ITGAL
28
Show member pathways
11.85 ITGB2 ITGAM
29
Show member pathways
11.82 ITGB2 ITGAM
30
Show member pathways
11.82 ITGB2 ITGAM ITGAL ITGA4
31 11.81 ITGB2 ITGA4
32 11.77 ITGB2 ITGAM
33 11.75 SELL ITGB2 ITGAL ITGA4
34 11.74 ITGB2 ITGAM ITGAL ITGA4
35 11.73 ITGB2 ITGAM ITGAL
36 11.72 ITGB2 ITGAM
37 11.7 ITGAM ITGA4
38 11.68 ITGB2 ITGAL
39 11.61 ITGAM ITGA4
40
Show member pathways
11.6 SELL ITGB2 ITGAM ITGAL ITGA4
41 11.58 ITGB2 ITGAM
42 11.57 SELL ITGAM
43 11.56 ITGB2 ITGAM ITGAL ITGA4
44 11.49 ITGB2 ITGAM ITGAL ITGA4
45 11.45 ITGAM ITGAL
46 11.43 ITGB2 ITGAM
47 11.39 ITGB2 ITGAM ITGAL
48 11.39 ITGB2 ITGAM ITGAL ITGA4
49 11.37 ITGB2 ITGAL
50 11.35 ITGB2 ITGAM

GO Terms for Idiopathic Eosinophilic Pneumonia

Cellular components related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.88 SELL ITGB2 ITGAM ITGAL ITGA4
2 extracellular exosome GO:0070062 9.76 ITGB2 ITGAM ITGAL ITGA4
3 external side of plasma membrane GO:0009897 9.58 SELL ITGB2 ITGAM
4 specific granule membrane GO:0035579 9.5 ITGB2 ITGAM ITGAL
5 tertiary granule membrane GO:0070821 9.43 ITGB2 ITGAM
6 plasma membrane raft GO:0044853 9.37 ITGB2 ITGAM
7 cell surface GO:0009986 9.35 SELL ITGB2 ITGAM ITGAL ITGA4
8 integrin alphaM-beta2 complex GO:0034688 9.26 ITGB2 ITGAM
9 integrin alphaL-beta2 complex GO:0034687 9.16 ITGB2 ITGAL
10 integrin complex GO:0008305 8.92 ITGB2 ITGAM ITGAL ITGA4

Biological processes related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.81 SELL ITGB2 ITGAM ITGAL
2 regulation of immune response GO:0050776 9.71 SELL ITGB2 ITGAL ITGA4
3 cell-matrix adhesion GO:0007160 9.67 ITGB2 ITGAL ITGA4
4 extracellular matrix organization GO:0030198 9.67 ITGB2 ITGAM ITGAL ITGA4
5 phagocytosis, engulfment GO:0006911 9.62 ITGB2 ITGAM
6 phagocytosis GO:0006909 9.62 ITGB2 ITGAL
7 positive regulation of neuron death GO:1901216 9.61 ITGB2 ITGAM
8 positive regulation of protein targeting to membrane GO:0090314 9.61 ITGB2 ITGAM
9 endodermal cell differentiation GO:0035987 9.6 ITGB2 ITGA4
10 heterotypic cell-cell adhesion GO:0034113 9.59 ITGB2 ITGA4
11 microglial cell activation GO:0001774 9.58 ITGB2 ITGAM
12 leukocyte tethering or rolling GO:0050901 9.58 SELL ITGA4
13 toll-like receptor 4 signaling pathway GO:0034142 9.57 ITGB2 ITGAM
14 positive regulation of superoxide anion generation GO:0032930 9.56 ITGB2 ITGAM
15 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.55 ITGB2 ITGAM
16 cell adhesion GO:0007155 9.55 SELL ITGB2 ITGAM ITGAL ITGA4
17 amyloid-beta clearance GO:0097242 9.54 ITGB2 ITGAM
18 receptor clustering GO:0043113 9.5 ITGB2 ITGAL ITGA4
19 positive regulation of neutrophil degranulation GO:0043315 9.48 ITGB2 ITGAM
20 negative regulation of dopamine metabolic process GO:0045963 9.46 ITGB2 ITGAM
21 positive regulation of prostaglandin-E synthase activity GO:2000363 9.43 ITGB2 ITGAM
22 leukocyte cell-cell adhesion GO:0007159 9.43 ITGB2 ITGAL ITGA4
23 integrin-mediated signaling pathway GO:0007229 9.26 ITGB2 ITGAM ITGAL ITGA4
24 positive regulation of microglial cell activation GO:1903980 9.22 ITGAM
25 leukocyte migration GO:0050900 9.02 SELL ITGB2 ITGAM ITGAL ITGA4

Molecular functions related to Idiopathic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.72 SELL ITGB2 ITGAM ITGAL ITGA4
2 protein heterodimerization activity GO:0046982 9.54 ITGB2 ITGAM ITGAL
3 heat shock protein binding GO:0031072 9.26 ITGB2 ITGAM
4 complement component C3b binding GO:0001851 9.16 ITGB2 ITGAM
5 ICAM-3 receptor activity GO:0030369 8.96 ITGB2 ITGAL
6 cell adhesion molecule binding GO:0050839 8.92 SELL ITGB2 ITGAL ITGA4

Sources for Idiopathic Eosinophilic Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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