MCID: IDP091
MIFTS: 42

Idiopathic Nephrotic Syndrome

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Idiopathic Nephrotic Syndrome

MalaCards integrated aliases for Idiopathic Nephrotic Syndrome:

Name: Idiopathic Nephrotic Syndrome 58 29 6

Characteristics:

Orphanet epidemiological data:

58
idiopathic nephrotic syndrome
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare renal diseases


External Ids:

UMLS via Orphanet 72 C3496337
Orphanet 58 ORPHA357502

Summaries for Idiopathic Nephrotic Syndrome

MalaCards based summary : Idiopathic Nephrotic Syndrome is related to nephrotic syndrome, type 2 and focal segmental glomerulosclerosis, and has symptoms including edema An important gene associated with Idiopathic Nephrotic Syndrome is NPHS2 (NPHS2 Stomatin Family Member, Podocin), and among its related pathways/superpathways are Allograft rejection and Toxoplasmosis. The drugs rituximab and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone, and related phenotypes are liver/biliary system and renal/urinary system

Related Diseases for Idiopathic Nephrotic Syndrome

Diseases related to Idiopathic Nephrotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 nephrotic syndrome, type 2 33.1 NPHS2 AXDND1
2 focal segmental glomerulosclerosis 32.8 TGFB1 NPHS2 ALB ACE
3 nephrotic syndrome 32.0 NPHS2 ALB ACE
4 end stage renal disease 30.9 NPHS2 ALB ACE
5 membranous nephropathy 30.8 NPHS2 ALB ACE
6 glomerular disease 30.7 NPHS2 ALB ACE
7 glomerulonephritis 30.6 TGFB1 NPHS2 ALB ACE
8 iga glomerulonephritis 30.5 NPHS2 ALB ACE
9 acute kidney tubular necrosis 30.3 ALB ACE
10 iga nephropathy 1 30.3 NPHS2 ACE
11 kidney disease 30.2 TGFB1 NPHS2 ALB ACE
12 hypertensive encephalopathy 30.2 ALB ACE
13 anuria 30.1 ALB ACE
14 diffuse mesangial sclerosis 30.0 TGFB1 NPHS2
15 chronic kidney disease 29.9 TGFB1 NPHS2 ALB ACE
16 hypokalemia 29.7 NR3C1 ALB ACE
17 alport syndrome 29.7 TGFB1 NPHS2 ALB
18 microvascular complications of diabetes 3 29.6 TGFB1 ALB ACE
19 pyelonephritis 29.6 TGFB1 ALB ACE
20 food allergy 29.4 IL4 IGHE ALB
21 toxocariasis 29.3 IL4 IGHE
22 ulcerative colitis 28.9 IL4 HLA-DRB1 ABCB1
23 colitis 28.9 IL4 HLA-DRB1 ABCB1
24 allergic rhinitis 28.8 NR3C1 IL4 IGHE
25 rhinitis 28.7 NR3C1 IL4 IGHE ALB
26 diabetes mellitus, type i 28.7 IL4 HLA-DRB1 ALB ACE
27 cataract 28.1 TGFB1 NR3C1 ALB ACE
28 systemic lupus erythematosus 27.9 TGFB1 NR3C1 IL4 HLA-DRB1 ALB ACE
29 diabetes mellitus 27.6 TGFB1 NR3C1 IL4 HLA-DRB1 ALB ACE
30 genetic steroid-resistant nephrotic syndrome 11.6
31 mesangial proliferative glomerulonephritis 10.5
32 proliferative glomerulonephritis 10.4
33 orthostatic proteinuria 10.3 ALB ACE
34 ige responsiveness, atopic 10.3
35 membranoproliferative glomerulonephritis 10.3
36 kidney papillary necrosis 10.3 ALB ACE
37 generalized atherosclerosis 10.3 ALB ACE
38 severe nonproliferative diabetic retinopathy 10.3 ALB ACE
39 intracranial embolism 10.3 ALB ACE
40 acute proliferative glomerulonephritis 10.3 NPHS2 ALB
41 hypertensive retinopathy 10.3 ALB ACE
42 hypertensive nephropathy 10.3 ALB ACE
43 constrictive pericarditis 10.3 ALB ACE
44 acute kidney failure 10.3
45 phenytoin toxicity 10.3 ALB ABCB1
46 acute diffuse nephritis 10.3 ACE ABCB1
47 renal artery disease 10.3 ALB ACE
48 background diabetic retinopathy 10.3 ALB ACE
49 idiopathic steroid-resistant nephrotic syndrome 10.3 NPHS2 ALB
50 cranial nerve palsy 10.3 ALB ACE

Graphical network of the top 20 diseases related to Idiopathic Nephrotic Syndrome:



Diseases related to Idiopathic Nephrotic Syndrome

Symptoms & Phenotypes for Idiopathic Nephrotic Syndrome

UMLS symptoms related to Idiopathic Nephrotic Syndrome:


edema

MGI Mouse Phenotypes related to Idiopathic Nephrotic Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.43 ABCB1 ACE ALB IL4 NR3C1 TGFB1
2 renal/urinary system MP:0005367 9.1 ACE ALB IL4 NPHS2 NR3C1 TGFB1

Drugs & Therapeutics for Idiopathic Nephrotic Syndrome

Drugs for Idiopathic Nephrotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 4 174722-31-7 10201696
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
3 Vaccines Phase 4
4 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
5 Hormones Phase 4
6 Hormone Antagonists Phase 4
7 Adrenocorticotropic Hormone Phase 4
8 Melanocyte-Stimulating Hormones Phase 4
9 beta-Endorphin Phase 4
10 Immunoglobulin A Phase 4
11 Immunologic Factors Phase 4
12 Antirheumatic Agents Phase 4
13 Antineoplastic Agents, Immunological Phase 4
14 Calcineurin Inhibitors Phase 4
15 Antibodies Phase 4
16 Immunoglobulins Phase 4
17
Valproic acid Approved, Investigational Phase 2, Phase 3 99-66-1 3121
18
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
19
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
20
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
21
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
22
Mycophenolic acid Approved Phase 3 24280-93-1 446541
23 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
24
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
25
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
26
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
27 Psychotropic Drugs Phase 2, Phase 3
28 Anticonvulsants Phase 2, Phase 3
29 Neurotransmitter Agents Phase 2, Phase 3
30 Alkylating Agents Phase 3
31 Methylprednisolone Acetate Phase 3
32 Anti-Infective Agents Phase 3
33 Antineoplastic Agents, Hormonal Phase 3
34 glucocorticoids Phase 3
35 Anti-Inflammatory Agents Phase 3
36 Antitubercular Agents Phase 3
37 Anti-Bacterial Agents Phase 3
38 Antibiotics, Antitubercular Phase 3
39 Immunoglobulins, Intravenous Phase 2, Phase 3
40 Anthelmintics Phase 3
41 Adjuvants, Immunologic Phase 3
42 Antiparasitic Agents Phase 3
43
ofatumumab Approved Phase 2 679818-59-8 6918251
44
Cetirizine Approved Phase 2 83881-51-0 2678
45
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
46
Promethazine Approved, Investigational Phase 2 60-87-7 4927
47
Acetaminophen Approved Phase 2 103-90-2 1983
48
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
49 Antiviral Agents Phase 1, Phase 2
50 Anti-HIV Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Study of Safety, Immunogenicity and Immunological Memory of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
2 Adjusted Steroid Therapy in Children With Idiopathic Nephrotic Syndrome Unknown status NCT02649413 Phase 4 Prednisone
3 Treatment of Nephrotic Syndrome Relapse With Low Steroid Dose Unknown status NCT02216747 Phase 4 prednisone 60 mg/meter square Body Surface Area;prednisone 45 mg;prednisone 30 mg
4 A Prospective, Randomized, Open-label Study Evaluating the Efficacy of Mycophenolate Mofetil in the Prevention of Relapse of Steroid Dependent Nephrotic Syndrome in Children Completed NCT01895894 Phase 4 Mycophenolate mofetil
5 The Treatment of Resistant Nephrotic Syndrome With ACTH Gel (ACTHAR) Completed NCT01129284 Phase 4 ACTHAR gel
6 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome Recruiting NCT02382575 Phase 4 Rituximab;Tacrolimus
7 A Multinational Prospective Study on the Duration of Steroid Therapy in Steroid Sensitive Nephrotic Syndrome Not yet recruiting NCT03878914 Phase 4 Corticosteroids
8 A Prospective Interventional Pilot Study on the Use of Valproic Acid for Treatment of Idiopathic Nephrotic Syndrome Unknown status NCT02896270 Phase 2, Phase 3 Valproic Acid
9 Cyclophosphamide Versus Mycophenolate Mofetil for Children With Steroid-dependent Idiopathic Nephrotic Syndrome : a Multicenter Randomized Controlled Trial Completed NCT01092962 Phase 3 Cyclophosphamide;Mycophenolate mofetil
10 A Prospective, Randomized, Double Blind, Placebo-controlled Phase II/III Study Evaluating the Efficacy of Rituximab in the Prevention of Relapse of Calcineurin Inhibitors Dependent Idiopathic Nephrotic Syndrome of Childhood Completed NCT01268033 Phase 2, Phase 3 Rituximab;Placebo
11 Lymphocyte Markers As Predictors Of Responsiveness To Rituximab Among Patients With Idiopathic Nephrotic Syndrome Recruiting NCT03501459 Phase 3 Rituximab
12 Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome Unresponsive to 8 Weeks of High Dose Prednisone Recruiting NCT03298698 Phase 3 Rituximab;Prednisone
13 Efficacy and Safety of Immunoglobulin Associated With Rituximab Versus Rituximab Alone in Childhood-Onset Steroid-dependent Nephrotic Syndrome Recruiting NCT03560011 Phase 2, Phase 3 immunoglobulin IV
14 A Multicenter, Randomised, Double-blind Placebo-controlled Trial Assessing the Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children. Recruiting NCT02818738 Phase 3 Levamisole Hydrochloride
15 Randomized, Multicentric, Open Label, Parallel Group Trial to Compare the Efficacy of 6-months Versus 3-months Therapy With Prednisolone for the First Episode of Idiopathic Nephrotic Syndrome in Children Younger Than 4 Years Recruiting NCT03141970 Phase 3 Prednisolone
16 Randomized Clinical Trial to Compare Efficacy and Safety of Repeated Courses of Rituximab to That of Maintenance Mycophenolate Mofetil Following Single Course of Rituximab in Maintaining Remission Over 24 Months Among Children With Steroid Dependent Nephrotic Syndrome Recruiting NCT03899103 Phase 3 Rituximab;Mycophenolate Mofetil
17 Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor-dependent Idiopathic Nephrotic Syndrome: an Open-label, Randomized, Controlled, Superiority Trial. Unknown status NCT02394119 Phase 2 Ofatumumab;Rituximab
18 Use of IL-2 for Pediatric, Multi Drug Resistant, Idiopathic Nephrotic Syndrome Completed NCT02455908 Phase 1, Phase 2 Proleukin®
19 Anti-CD20, Rituximab, for the Treatment of Recurrent or Primary Resistant Focal Segmental Glomerulosclerosis (FSGS) Completed NCT00550342 Phase 2 rituximab
20 Efficacy of Chimeric Monoclonal Anti-CD20 Antibodies (Rituximab Biosimilar) in the Treatment of Childhood Steroid-dependent Nephrotic Syndrome and Development of Cell Biomarkers Predicting Outcome. The RTX 4 Trial. Recruiting NCT04402580 Phase 2 Rituximab Biosimilar;Mycophenolate Mofetil
21 A Phase 2 Open-label Study to Evaluate the Efficacy of Allogeneic Human Cord Blood-derived Mesenchymal Stromal Cells in Maintaining Remission After Immunosuppressive Therapy Withdrawal in Pediatric Patients With Steroid-dependent Nephrotic Syndrome Enrolling by invitation NCT04034316 Phase 2
22 Treatment of Steroid Dependent Idiopathic Nephrotic Syndrome in Children With Low Doses of Interleukin 2: a Pilot Study Withdrawn NCT02997150 Phase 2 IL-2 Low dose
23 Allogenic Adipose Derived Mesenchymal Stromal Cells Transplantation to Improve Kidney Function in Refractory Primary Nephrotic Syndrome (Focal Segmental Glomerulosclerosis,FSGS) ,a Phase I Clinical Trial Unknown status NCT02382874 Phase 1
24 A Dose-Finding Pilot Study of ACTH on the Serum Lipoprotein Profile and Proteinuria in Patients With Idiopathic Membranous Nephropathy (MN) Completed NCT00805753 Phase 1 ACTH
25 Diagnostic and Prognostic Value of Miss-1 Study in Children and Adult With Nephrotic Syndrome MISSNEPHROTIQUE Unknown status NCT03592030
26 Steroid Treatment of Childhood Idiopathic Nephrotic Syndrome: Epidemiology, Therapeutic Adequacy, Medium and Long Term Outcomes. A Prospective Observational Cohort Study. Unknown status NCT01386957
27 Safety and Efficacy of Combination Acthar Gel and Tacrolimus in the Treatment of Steroid Resistant Nephrotic Syndrome Unknown status NCT03042637 Acthar Gel and Tacrolimus
28 Factors of Steroid Dependency in Idiopathic Nephrotic Syndrome Completed NCT01609426
29 Angiotensin Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome Completed NCT00172276
30 Viral Infection of Lymphoid Cells Occuring at the First Manifestation of Idiopathic Nephrotic Syndrome Completed NCT00577525
31 PHARMACOKINETICS OF CYCLOSPORIN - A MICROEMULSION IN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME Completed NCT01616446
32 Kidney Disease Biomarkers Completed NCT00255398
33 Fluid Balance, Hormones and Urine Proteomics in Nephrotic Syndrome in Childhood Completed NCT00690586
34 Effect of Oral Galactose on the Level of Focal Sclerosis Permeability Factor and Proteinuria in Children With Steroid Resistant Nephrotic Syndrome: A Pilot Study Completed NCT01113385 D-Galactose
35 Effect of Daily Transcutaneous Auricular Vagus Nerve (taVNS) Stimulation on Proteinuria in Pediatric Patients With Idiopathic Nephrotic Syndrome Recruiting NCT04169776
36 A National Prospective Cohort of Patients With Idiopathic Nephrotic Syndrome Beginning in Childhood. Recruiting NCT04207580
37 The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry) Recruiting NCT03949972
38 A Pilot Trial of UrApp, a Novel Mobile Application for Childhood Nephrotic Syndrome Management Recruiting NCT04075656
39 Nephrotic Syndrome Study Network Under the Rare Diseases Clinical Research Network Recruiting NCT01209000
40 A Prospective Observational Study to Assess the Efficacy an Safety of Glucocorticoid Therapy in the Treatment of Adult Idiopathic Nephrotic Syndrome Active, not recruiting NCT02298335 prednisone
41 From Immune System Damage to Podocyte Cell Damage: Prospective Database and Biological Collection of Patients (Children and Adults) With Minimal Glomerular Injury Nephrotic Syndrome (MGLS) and Primary Segmental and Focal Hyalinosis (HSFP) Not yet recruiting NCT04174066

Search NIH Clinical Center for Idiopathic Nephrotic Syndrome

Genetic Tests for Idiopathic Nephrotic Syndrome

Genetic tests related to Idiopathic Nephrotic Syndrome:

# Genetic test Affiliating Genes
1 Idiopathic Nephrotic Syndrome 29

Anatomical Context for Idiopathic Nephrotic Syndrome

MalaCards organs/tissues related to Idiopathic Nephrotic Syndrome:

40
Kidney, T Cells, Bone, Endothelial, B Cells, Monocytes, Neutrophil

Publications for Idiopathic Nephrotic Syndrome

Articles related to Idiopathic Nephrotic Syndrome:

(show top 50) (show all 1245)
# Title Authors PMID Year
1
Role of cathepsin L in idiopathic nephrotic syndrome in children. 61
32289645 2020
2
Parental understanding of relapsing idiopathic nephrotic syndrome-Where are the knowledge gaps? 61
31773812 2020
3
Idiopathic nephrotic syndrome in children: role of regulatory T cells and gut microbiota. 61
32570267 2020
4
Case Report on Paediatric Nephrotic Syndrome. 61
32549884 2020
5
[Vaccine recommendations for children with idiopathic nephrotic syndrome]. 61
32278737 2020
6
IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome. 61
32382828 2020
7
Annexin V in children with idiopathic nephrotic syndrome treated with cyclosporine A. 61
32469166 2020
8
Hsp90 inhibition aggravates adriamycin-induced podocyte injury through intrinsic apoptosis pathway. 61
32156599 2020
9
Glomerular endothelial cells and podocytes can express CD80 in patients with minimal change disease during relapse. 61
32399663 2020
10
Prediction of Short- and Long-Term Outcomes in Childhood Nephrotic Syndrome. 61
32280840 2020
11
A dual efficacy-implementation trial of a novel mobile application for childhood nephrotic syndrome management: the UrApp for childhood nephrotic syndrome management pilot study protocol (UrApp pilot study). 61
32272901 2020
12
Current Perspectives in Management of Edema in Nephrotic Syndrome. 61
32232733 2020
13
Health-related quality of life in Egyptian children with nephrotic syndrome. 61
32016684 2020
14
Idiopathic nephrotic syndrome and serum permeability factors: a molecular jigsaw puzzle. 61
31848752 2020
15
The role of real-time shear wave elastography in the diagnosis of idiopathic nephrotic syndrome and evaluation of the curative effect. 61
32107581 2020
16
Effect of prednisolone on linear growth in children with nephrotic syndrome. 61
30240629 2020
17
The Supportive Treatment of IgA Nephropathy and Idiopathic Nephrotic Syndrome: How Useful are Omega-3 Polyunsaturated Fatty Acids? 61
32161487 2020
18
Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome. 61
31978139 2020
19
CTLA4-Ig Abatacept Ameliorates Proteinuria by Regulating Circulating Treg/IL-17 in Adriamycin-Induced Nephropathy Rats. 61
32420329 2020
20
CD80 expression and infiltrating regulatory T cells in idiopathic nephrotic syndrome of childhood. 61
31513327 2019
21
Immunoadsorption in nephrotic syndrome: Where are we now and where are we going from here? 61
31447217 2019
22
Molecular stratification of idiopathic nephrotic syndrome. 61
31654044 2019
23
MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome. 61
31463578 2019
24
Quality of life in children with severe forms of idiopathic nephrotic syndrome in stable remission-A cross-sectional study. 61
31240744 2019
25
Infrequent tacrolimus-induced nephrotoxicity in French patients with steroid-dependent nephrotic syndrome. 61
31515630 2019
26
Clinical significance of IgM deposition in pediatric minimal change disease. 61
31890840 2019
27
Interventions for idiopathic steroid-resistant nephrotic syndrome in children. 61
31749142 2019
28
Bone mineral density and its influencing factors in children with idiopathic nephrotic syndrome: a prospective observational study. 61
31408410 2019
29
Atypical IgM on T cells predict relapse and steroid dependence in idiopathic nephrotic syndrome. 61
31285081 2019
30
Human Th17 cells produce a soluble mediator that increases podocyte motility via signaling pathways that mimic PAR-1 activation. 61
31339775 2019
31
Impact of acute kidney injury at the onset of idiopathic nephrotic syndrome in Japanese children. 61
31055685 2019
32
Tacrolimus can induce remission in cyclosporine and mycophenolate mofetil resistant pediatric onset nephrotic syndrome. 61
31705749 2019
33
Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience. 61
31489435 2019
34
High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells. 61
31510052 2019
35
Prognosis and acute complications at the first onset of idiopathic nephrotic syndrome in children: a nationwide survey in Japan (JP-SHINE study). 61
31550360 2019
36
Study protocol: multicenter double-blind, randomized, placebo-controlled trial of rituximab for the treatment of childhood-onset early-stage uncomplicated frequently relapsing or steroid-dependent nephrotic syndrome (JSKDC10 trial). 61
31375087 2019
37
[Idiopathic nephrotic syndrome: une Arlésienne?] 61
31532378 2019
38
Relationships between the clinical phenotypes and genetic variants associated with the immunological mechanism in childhood idiopathic nephrotic syndrome: protocol for a prospective observational single-centre cohort study. 61
31467050 2019
39
Prevention of relapses with levamisole as adjuvant therapy in children with a first episode of idiopathic nephrotic syndrome: study protocol for a double blind, randomised placebo-controlled trial (the LEARNS study). 61
31375606 2019
40
Amelioration of Lipopolysaccharide-Induced Nephrotic Proteinuria by NFAT5 Depletion Involves Suppressed NF-κB Activity. 61
30826989 2019
41
Bone mineral density and vitamin D status in children with remission phase of steroid-sensitive nephrotic syndrome. 61
31464242 2019
42
Levamisole in Children with Idiopathic Nephrotic Syndrome: Clinical Efficacy and Pathophysiological Aspects. 61
31208104 2019
43
Carotid intima-media thickness in children with idiopathic nephrotic syndrome: A single center cross-sectional study
. 61
31079597 2019
44
Mutational spectrum and novel candidate genes in Chinese children with sporadic steroid-resistant nephrotic syndrome. 61
30712057 2019
45
Treating the idiopathic nephrotic syndrome: are steroids the answer? 61
29869116 2019
46
Plasma Free Homocysteine Levels in Children with Idiopathic Nephrotic Syndrome. 61
31142965 2019
47
European Society of Pediatric Nephrology survey on current practice regarding recurrent focal segmental glomerulosclerosis after pediatric kidney transplantation. 61
30825259 2019
48
Five-year outcome of children with idiopathic nephrotic syndrome: the NEPHROVIR population-based cohort study. 61
30552564 2019
49
Remission of proteinuria in multidrug-resistant idiopathic nephrotic syndrome following immunoglobulin immunoadsorption. 61
30230027 2019
50
Idiopathic nephrotic syndrome and rituximab: may we predict circulating B lymphocytes recovery? 61
30542932 2019

Variations for Idiopathic Nephrotic Syndrome

ClinVar genetic disease variations for Idiopathic Nephrotic Syndrome:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NPHS2 NM_014625.3(NPHS2):c.714G>T (p.Arg238Ser)SNV Pathogenic/Likely pathogenic 556556 rs748812981 1:179526186-179526186 1:179557051-179557051
2 NPHS2 NM_144696.6(AXDND1):c.3032-1887G>ASNV Pathogenic/Likely pathogenic 562398 rs780761368 1:179521760-179521760 1:179552625-179552625
3 AXDND1 , NPHS2 NM_014625.4(NPHS2):c.868G>A (p.Val290Met)SNV Pathogenic/Likely pathogenic 126418 rs200482683 1:179521743-179521743 1:179552608-179552608
4 AXDND1 , NPHS2 NM_144696.6(AXDND1):c.3032-1891_3032-1890deldeletion Pathogenic/Likely pathogenic 188823 rs749740335 1:179521755-179521756 1:179552620-179552621
5 NPHS2 NM_144696.6(AXDND1):c.3032-21A>TSNV Conflicting interpretations of pathogenicity 447882 rs775006954 1:179523626-179523626 1:179554491-179554491
6 NPHS2 NM_014625.3(NPHS2):c.413G>A (p.Arg138Gln)SNV Conflicting interpretations of pathogenicity 5360 rs74315342 1:179530462-179530462 1:179561327-179561327
7 NPHS2 NM_014625.3(NPHS2):c.467dup (p.Leu156fs)duplication Conflicting interpretations of pathogenicity 556941 rs528833893 1:179528880-179528881 1:179559745-179559746

Expression for Idiopathic Nephrotic Syndrome

Search GEO for disease gene expression data for Idiopathic Nephrotic Syndrome.

Pathways for Idiopathic Nephrotic Syndrome

GO Terms for Idiopathic Nephrotic Syndrome

Biological processes related to Idiopathic Nephrotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to dexamethasone stimulus GO:0071549 9.26 TGFB1 NR3C1
2 myeloid dendritic cell differentiation GO:0043011 9.16 TGFB1 IL4
3 positive regulation of mononuclear cell migration GO:0071677 8.96 TGFB1 IL4
4 mononuclear cell proliferation GO:0032943 8.62 TGFB1 ACE

Sources for Idiopathic Nephrotic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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