MCID: IDP064
MIFTS: 40

Idiopathic Neutropenia

Categories: Rare diseases

Aliases & Classifications for Idiopathic Neutropenia

MalaCards integrated aliases for Idiopathic Neutropenia:

Name: Idiopathic Neutropenia 52 71
Nonimmune Chronic Idiopathic Neutropenia of Adults 52
Neutropenia, Nonimmune Chronic Idiopathic, Adult 71
Ni-Cina 52

Classifications:



External Ids:

UMLS 71 C0948109 C1842930

Summaries for Idiopathic Neutropenia

NIH Rare Diseases : 52 Idiopathic neutropenia is an acquired form of severe chronic neutropenia whose cause is unknown. Neutropenia is a blood condition that causes a reduced number or complete absence of neutrophils , a type of white blood cell that is responsible for much of the body's protection against infection. Symptoms include fever, moth sores, and other types of infections. Neutropenia idiopathic may occur in children and adults. Frequency and severity of infections appear to be directly related to neutrophil count; while clinical problems in individual patients may vary, in general, those patients with more severe neutropenia have more frequent infections. Most patients respond well to granulocyte-colony stimulating factor (G-CSF). Long-term treatment is usually required.

MalaCards based summary : Idiopathic Neutropenia, also known as nonimmune chronic idiopathic neutropenia of adults, is related to helicobacter pylori infection and monoclonal gammopathy of uncertain significance. An important gene associated with Idiopathic Neutropenia is GFI1 (Growth Factor Independent 1 Transcriptional Repressor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include bone, neutrophil and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Idiopathic Neutropenia

Diseases related to Idiopathic Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 561)
# Related Disease Score Top Affiliating Genes
1 helicobacter pylori infection 30.4 IL1B CCL5 CASP3
2 monoclonal gammopathy of uncertain significance 30.1 TNF IL6 CD40LG
3 cyclic neutropenia 30.1 TNF IL1B GFI1 CSF3R
4 neutropenia 29.7 THPO IL6 IL1RN GFI1 FASLG CSF3R
5 cellulitis 29.5 TNF IL6 IL10 CD40LG
6 gingival overgrowth 29.4 TNF TGFB1 IL6 IL1A
7 thrombocytopenia due to platelet alloimmunization 29.4 THPO IL10 CD40LG
8 lymphopenia 29.2 IL6 IL2RA IL10 FASLG
9 cytomegalovirus infection 29.2 TNF IL6 IL1B CCL5 CASP3
10 rhinitis 29.2 TNF IL6 IL10 FCER2 CCL5
11 gingivitis 29.0 TNF IL6 IL1B IL1A IL10 CCL5
12 iron deficiency anemia 28.9 TNF THPO IL6
13 temporal arteritis 28.8 TNF IL6 IL1RN HLA-DRB1 CD40LG CCL5
14 pharyngitis 28.6 TNF IL6 IL1RN IL1B HLA-DRB1 CD40LG
15 otitis media 28.4 TNF TLR4 IL6 IL1B IL10 CD40LG
16 cystic fibrosis 28.4 TNF TLR4 TGFB1 IL6 IL1B IL10
17 cervical cancer 28.1 TNF TLR4 IL6 IL1A IL10 FASLG
18 leukemia, acute myeloid 28.1 TNF THPO IL6 IL10 GFI1 FASLG
19 periodontitis 28.0 TNF TLR4 IL6 IL1RN IL1B IL1A
20 bacterial infectious disease 27.5 TNF TLR4 IL6 IL1RN IL1B IL1A
21 relapsing-remitting multiple sclerosis 27.3 TNF TLR4 IL6 IL1RN IL1B IL10
22 autoimmune disease 26.6 TNF TGFB1 IL6 IL2RA IL1RN IL1B
23 multiple sclerosis 26.4 TNF TLR4 IL6 IL2RA IL1RN IL1B
24 osteoporosis 26.4 TNF TLR4 TGFB1 IL6 IL2RA IL1RN
25 thrombocytopenia 26.2 TNF TLR4 THPO IL6 IL1RN IL1B
26 aplastic anemia 25.9 TNF THPO TGFB1 IL6 IL2RA IL1RN
27 neutropenia, nonimmune chronic idiopathic, of adults 12.3
28 punctate inner choroidopathy 10.5 TNF IL10
29 heterophyiasis 10.5 CD40LG CASP3
30 tropical endomyocardial fibrosis 10.5 TNF IL10
31 astrakhan spotted fever 10.5 CD40LG CCL5
32 microscopic polyangiitis 10.5 TNF HLA-DRB1
33 beryllium disease 10.4 TNF HLA-DRB1
34 pustulosis palmaris et plantaris 10.4 TNF TGFB1 CD40LG
35 multifocal choroiditis 10.4 TNF IL10
36 type ii mixed cryoglobulinemia 10.4 HLA-DRB1 FASLG
37 nephrosclerosis 10.4 TNF TGFB1 CASP3
38 leukoregulin 10.4 TGFB1 IL1A
39 spotted fever rickettsiosis 10.4 TNF IL10 CCL5
40 chronic beryllium disease 10.4 TNF HLA-DRB1
41 clonorchiasis 10.3 TNF TGFB1 IL10
42 orofacial granulomatosis 10.3 TNF IL10 CCL5
43 cow milk allergy 10.3 TNF TGFB1 IL10
44 milk allergy 10.3 TNF TGFB1 IL10
45 transient hypogammaglobulinemia 10.3 TNF IL10 CD40LG
46 histoplasmosis 10.3 TNF HLA-DRB1 CD40LG
47 sporotrichosis 10.3 TNF IL10 CD40LG
48 mesial temporal lobe epilepsy with hippocampal sclerosis 10.3 IL1B HLA-DRB1
49 choroiditis 10.3 TNF IL10 CD40LG
50 kashin-beck disease 10.3 TNF IL1B

Graphical network of the top 20 diseases related to Idiopathic Neutropenia:



Diseases related to Idiopathic Neutropenia

Symptoms & Phenotypes for Idiopathic Neutropenia

GenomeRNAi Phenotypes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CASP3 CD40LG IL10 IL1A IL1B IL2RA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CASP3 CD40LG IL10 IL1A IL1B IL2RA
3 Decreased viability with paclitaxel GR00179-A-1 9.26 CASP3 IL10 TGFB1
4 Decreased viability with paclitaxel GR00179-A-3 9.26 TGFB1

MGI Mouse Phenotypes related to Idiopathic Neutropenia:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.39 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
2 immune system MP:0005387 10.33 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
3 cardiovascular system MP:0005385 10.3 CASP3 CD40LG FASLG IL10 IL1A IL1B
4 cellular MP:0005384 10.29 CASP3 CD40LG CSF3R FASLG FCER2 GFI1
5 homeostasis/metabolism MP:0005376 10.28 CASP3 CD40LG FASLG FCER2 IL10 IL1A
6 mortality/aging MP:0010768 10.17 CASP3 CD40LG CSF3R FASLG FCER2 GFI1
7 digestive/alimentary MP:0005381 10.15 CASP3 FASLG FCER2 IL10 IL2RA IL6
8 endocrine/exocrine gland MP:0005379 10.13 CASP3 CD40LG FASLG GFI1 IL10 IL2RA
9 integument MP:0010771 10.11 CASP3 CD40LG FASLG IL10 IL1A IL1B
10 neoplasm MP:0002006 9.86 FASLG IL10 IL1A IL1B IL6 TGFB1
11 respiratory system MP:0005388 9.76 CASP3 FASLG IL10 IL2RA IL6 TGFB1
12 skeleton MP:0005390 9.7 CASP3 CD40LG FASLG IL10 IL1B IL1RN
13 vision/eye MP:0005391 9.28 CASP3 FASLG IL10 IL2RA IL6 TGFB1

Drugs & Therapeutics for Idiopathic Neutropenia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1B, Open-Label, Multicenter Study of Mavorixafor in Patients With Severe Congenital Neutropenia and Chronic Neutropenia Disorders Not yet recruiting NCT04154488 Phase 1 Mavorixafor

Search NIH Clinical Center for Idiopathic Neutropenia

Genetic Tests for Idiopathic Neutropenia

Anatomical Context for Idiopathic Neutropenia

MalaCards organs/tissues related to Idiopathic Neutropenia:

40
Bone, Neutrophil, Bone Marrow, T Cells, Myeloid, Liver, B Cells

Publications for Idiopathic Neutropenia

Articles related to Idiopathic Neutropenia:

(show top 50) (show all 208)
# Title Authors PMID Year
1
Altered Monocyte Subsets in Patients with Chronic Idiopathic Neutropenia. 61
31655960 2019
2
Severe Transitory Neonatal Neutropenia Associated with Maternal Autoimmune or Idiopathic Neutropenia. 61
30900095 2019
3
Idiopathic neutropenia of infancy: Data from the Italian Neutropenia Registry. 61
30456824 2019
4
Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly. 61
30527923 2018
5
Diagnostic value of cell bound and circulating neutrophil antibody detection in pediatric neutropenia. 61
29230955 2018
6
A Phase I study to determine safety, pharmacokinetics, and pharmacodynamics of ANF-RHO™, a novel PEGylated granulocyte colony-stimulating factor, in healthy volunteers. 61
28752433 2018
7
[Reference guide for adult chronic neutropenia]. 61
30078793 2018
8
Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors. 61
28535087 2017
9
Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia. 61
28732781 2017
10
Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function. 61
28652245 2017
11
The relationship between idiopathic cytopenias/dysplasias of uncertain significance (ICUS/IDUS) and autoimmunity. 61
28586251 2017
12
An update on the diagnosis and treatment of chronic idiopathic neutropenia. 61
27841775 2017
13
Minor populations of paroxysmal nocturnal hemoglobinuria-type cells in patients with chronic idiopathic neutropenia. 61
27124520 2016
14
Reduced 25-OH vitamin D in patients with autoimmune cytopenias, clinical correlations and literature review. 61
26988993 2016
15
[Laparoscopic Nephrectomy in Infant with Diamond Blackfan Syndrome]. 61
27217013 2016
16
Polymyalgia Rheumatica Revealing a Lymphoma: A Two-Case Report. 61
27597921 2016
17
Chronic Neutropenia in Childhood: Experience From a Single Center. 61
26479986 2016
18
Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry. 61
24997149 2014
19
Familial CD3+ T large granular lymphocyte leukemia: evidence that genetic predisposition and antigen selection promote clonal cytotoxic T-cell responses. 61
24180333 2014
20
Etiology, clinical outcome, and laboratory features in children with neutropenia: analysis of 104 cases. 61
24325465 2014
21
Unexplained chronic leukopenia treated with oral iron supplements. 61
24346817 2014
22
Association between helicobacter pylori infection and chronic idiopathic neutropenia. 61
23771659 2013
23
Infectious complications in children with severe congenital, autoimmune or idiopathic neutropenia: a retrospective study from the Italian Neutropenia Registry. 61
23249920 2013
24
[Polyclonal CD8+/CD57+ T cell expansions: clinical significance]. 61
22789311 2013
25
Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination. 61
23417376 2013
26
Mesenchymal stem cells in immune-mediated bone marrow failure syndromes. 61
24386000 2013
27
Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia. 61
22875614 2012
28
Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia. 61
22133767 2012
29
An acquired CSF3R mutation in an adult chronic idiopathic neutropenia patient who developed acute myeloid leukaemia. 61
22146088 2012
30
Clinical manifestations and outcomes of pediatric chronic neutropenia. 61
22526211 2012
31
An unusual presentation of juvenile systemic lupus erythematosus. 61
22409521 2012
32
Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4. 61
22127462 2012
33
Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. 61
22092365 2012
34
Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia. 61
22956967 2012
35
Long-term outcomes of myeloid growth factor treatment. 61
21900223 2011
36
Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-β1. 61
21047210 2011
37
Evaluation of TET2 deletions in myeloid disorders: a fluorescence in situ hybridization analysis of 109 cases. 61
21087791 2011
38
The role of CD40/CD40 ligand interactions in bone marrow granulopoiesis. 61
22125452 2011
39
T-cell receptor Vβ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. 61
20864416 2010
40
Idiopathic neutropenia with fewer than 5% dysplasia may be a distinct entity of idiopathic cytopenia of undetermined significance. 61
19823822 2010
41
Case history: individualized homeopathy and severe chronic idiopathic neutropenia (SCN). 61
20674845 2010
42
Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma. 61
19880437 2010
43
[Biosimilar filgrastim: from development to record]. 61
20920854 2010
44
The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. 61
19614955 2009
45
Idiopathic neutropenia of childhood is associated with Fas/FasL expression. 61
18819843 2008
46
Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. 61
21082926 2008
47
Clonal predominance of CD8(+) T cells in patients with unexplained neutropenia. 61
18279717 2008
48
Chronic idiopathic neutropenias and severe congenital neutropenia. 61
18043240 2008
49
[Hereditary neutropenia and T-cell lymphoma]. 61
19227315 2008
50
Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia. 61
17961177 2007

Variations for Idiopathic Neutropenia

Expression for Idiopathic Neutropenia

Search GEO for disease gene expression data for Idiopathic Neutropenia.

Pathways for Idiopathic Neutropenia

Pathways related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 TNF TLR4 TGFB1 IL6 IL2RA IL1RN
2
Show member pathways
13.95 TNF THPO TGFB1 IL6 IL2RA IL1B
3
Show member pathways
13.7 TNF TLR4 THPO TGFB1 IL6 IL2RA
4
Show member pathways
13.64 TNF THPO TGFB1 IL6 IL2RA IL1B
5
Show member pathways
13.52 TNF TLR4 THPO TGFB1 IL6 IL2RA
6
Show member pathways
13.43 TNF THPO TGFB1 IL6 IL2RA IL1B
7
Show member pathways
13.32 TNF TLR4 IL2RA IL1B IL1A HMGB1
8
Show member pathways
13.27 TNF TLR4 TGFB1 IL6 IL1B IL10
9
Show member pathways
13.14 TNF TGFB1 IL6 IL2RA IL1RN IL1B
10
Show member pathways
13.11 TNF TLR4 IL6 IL2RA FASLG CSF3R
11
Show member pathways
13.06 TNF TLR4 IL6 IL1B FASLG CCL5
12
Show member pathways
12.99 TNF TGFB1 IL6 IL2RA IL1B IL1A
13 12.95 TGFB1 IL6 IL2RA FASLG CSF3R CASP3
14 12.94 TNF IL6 IL1B HLA-DRB1 FASLG CCL5
15
Show member pathways
12.94 TNF TLR4 IL6 IL2RA IL1B IL1A
16 12.88 TNF TGFB1 IL1B IL1A FASLG CASP3
17
Show member pathways
12.88 TNF TLR4 IL6 IL1B HMGB1 CCL5
18
Show member pathways
12.88 TNF TLR4 THPO TGFB1 IL6 IL1B
19
Show member pathways
12.79 TNF IL1B IL1A FASLG CD40LG CASP3
20
Show member pathways
12.78 TNF TLR4 TGFB1 IL6 IL1B IL1A
21
Show member pathways
12.77 TNF TLR4 TGFB1 IL6 IL2RA IL1B
22
Show member pathways
12.76 TNF TLR4 IL1B IL1A FASLG CD40LG
23 12.74 TNF IL2RA IL1RN IL1B IL10 FASLG
24
Show member pathways
12.72 TNF IL2RA IL10 HLA-DRB1 CD40LG
25
Show member pathways
12.48 THPO IL6 IL2RA IL10 CSF3R
26 12.47 TNF TGFB1 IL6 IL2RA HLA-DRB1
27 12.47 TNF TLR4 IL6 IL1B FASLG CASP3
28
Show member pathways
12.46 TNF IL6 IL2RA IL10 CCL5
29 12.45 TNF TLR4 IL1B CCL5
30
Show member pathways
12.44 TNF THPO TGFB1 IL6 IL2RA IL1B
31
Show member pathways
12.43 TNF TLR4 IL6 IL1B IL1A
32 12.43 TNF TLR4 TGFB1 FASLG CASP3
33
Show member pathways
12.41 TNF IL6 IL1B CASP3
34
Show member pathways
12.41 TNF IL6 IL1B CCL5
35
Show member pathways
12.39 TNF TLR4 IL1B IL1A HMGB1 FASLG
36 12.37 TNF TLR4 IL6 IL1B CCL5
37 12.37 TNF IL6 IL1RN IL1B IL1A IL10
38
Show member pathways
12.36 TNF IL6 IL1RN IL1B IL1A
39
Show member pathways
12.36 TNF TLR4 TGFB1 IL1B IL1A IL10
40
Show member pathways
12.35 TNF TLR4 IL6 IL1A
41 12.34 TNF FASLG CD40LG CASP3
42 12.32 TNF TLR4 TGFB1 IL6 CASP3
43
Show member pathways
12.32 TNF TLR4 IL6 IL1B FASLG
44
Show member pathways
12.31 TNF IL1A FASLG CASP3
45
Show member pathways
12.3 TNF IL6 IL1B IL10
46 12.28 TNF TLR4 TGFB1 IL6 IL1B IL1A
47
Show member pathways
12.25 TNF TLR4 TGFB1 IL6 IL1B IL10
48 12.23 TNF TLR4 TGFB1 IL6 IL1B IL1A
49
Show member pathways
12.2 TNF TLR4 IL6 IL1B HMGB1
50
Show member pathways
12.19 TGFB1 IL6 IL10 FASLG

GO Terms for Idiopathic Neutropenia

Cellular components related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.93 TNF THPO TGFB1 IL6 IL1RN IL1B
2 cell surface GO:0009986 9.86 TNF TLR4 TGFB1 IL2RA HMGB1 HLA-DRB1
3 external side of plasma membrane GO:0009897 9.56 TNF TLR4 IL2RA HLA-DRB1 FCER2 FASLG
4 extracellular region GO:0005576 9.47 TNF THPO TGFB1 IL6 IL1RN IL1B

Biological processes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 TLR4 THPO TGFB1 IL6 IL1RN IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.26 TNF TLR4 TGFB1 IL6 IL1B IL1A
3 negative regulation of cell proliferation GO:0008285 10.14 TGFB1 IL6 IL1B IL1A IL10
4 positive regulation of gene expression GO:0010628 10.14 TNF TLR4 TGFB1 IL6 IL1B IL1A
5 positive regulation of apoptotic process GO:0043065 10.11 TNF TGFB1 IL6 HMGB1 FASLG CASP3
6 MAPK cascade GO:0000165 10.06 TNF TGFB1 IL2RA IL1B CCL5
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.04 TNF TLR4 THPO TGFB1 HMGB1 CCL5
8 positive regulation of protein phosphorylation GO:0001934 10.03 TNF THPO TGFB1 IL1B
9 response to lipopolysaccharide GO:0032496 10.02 TLR4 IL1B IL10 FASLG CASP3
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 TNF TLR4 IL1RN IL1B IL1A FASLG
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.98 TNF IL6 IL1B IL10
12 response to organic substance GO:0010033 9.96 TNF TGFB1 IL10 CASP3
13 cellular response to mechanical stimulus GO:0071260 9.93 TLR4 TGFB1 IL1B
14 apoptotic signaling pathway GO:0097190 9.93 TNF TLR4 FASLG CASP3
15 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 TNF TLR4 TGFB1 IL6 IL1B CD40LG
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 CCL5
17 regulation of insulin secretion GO:0050796 9.92 TNF IL1B CCL5
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.92 TNF TLR4 IL1B HMGB1
19 neutrophil chemotaxis GO:0030593 9.92 IL1RN IL1B IL1A CSF3R CCL5
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF IL6 CCL5
21 positive regulation of neuron apoptotic process GO:0043525 9.91 TNF FASLG CASP3
22 cellular response to lipopolysaccharide GO:0071222 9.91 TNF TLR4 IL6 IL1RN IL1B IL1A
23 negative regulation of fat cell differentiation GO:0045599 9.9 TNF TGFB1 IL6
24 negative regulation of T cell proliferation GO:0042130 9.9 TGFB1 IL2RA IL10 HLA-DRB1
25 inflammatory response GO:0006954 9.9 TNF TLR4 TGFB1 IL6 IL1RN IL1B
26 positive regulation of cell division GO:0051781 9.89 TGFB1 IL1B IL1A
27 extrinsic apoptotic signaling pathway GO:0097191 9.89 TNF TGFB1 FASLG
28 positive regulation of epithelial to mesenchymal transition GO:0010718 9.89 TGFB1 IL6 IL1B
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.89 TNF TLR4 IL1B
30 cellular response to organic cyclic compound GO:0071407 9.89 TNF TGFB1 IL1B CCL5 CASP3
31 positive regulation of interferon-gamma production GO:0032729 9.88 TNF TLR4 IL1B
32 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.88 TNF IL1B IL1A
33 negative regulation of mitotic cell cycle GO:0045930 9.88 TNF TGFB1 IL10
34 protein kinase B signaling GO:0043491 9.88 TNF TGFB1 IL1B CCL5
35 positive regulation of interleukin-6 secretion GO:2000778 9.88 TNF TLR4 IL1B HMGB1
36 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL1RN IL10 CASP3
37 negative regulation of interleukin-6 production GO:0032715 9.87 TNF TLR4 IL10
38 positive regulation of interleukin-6 production GO:0032755 9.87 TNF TLR4 IL6 IL1RN IL1B IL1A
39 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.86 IL1B IL1A CASP3
40 T cell homeostasis GO:0043029 9.86 TGFB1 IL2RA CASP3
41 negative regulation of interferon-gamma production GO:0032689 9.86 TLR4 IL10 HMGB1 HLA-DRB1
42 positive regulation of cytokine secretion GO:0050715 9.85 TNF IL1A IL10
43 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
44 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR4 IL1B
45 positive regulation of interleukin-12 production GO:0032735 9.85 TLR4 HMGB1 CD40LG
46 positive regulation of JAK-STAT cascade GO:0046427 9.85 TNF IL6 IL10 CCL5
47 positive regulation of JNK cascade GO:0046330 9.85 TNF TLR4 IL1RN IL1B IL1A HMGB1
48 positive regulation of interleukin-10 production GO:0032733 9.84 TLR4 HMGB1 CD40LG
49 positive regulation of vascular endothelial growth factor production GO:0010575 9.84 TGFB1 IL6 IL1B IL1A
50 positive regulation of chemokine production GO:0032722 9.83 TNF TLR4 IL6

Molecular functions related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.3 TNF TLR4 TGFB1 IL6 IL2RA IL1RN
2 growth factor activity GO:0008083 9.62 THPO TGFB1 IL6 IL10
3 integrin binding GO:0005178 9.56 IL1B HMGB1 FCER2 CD40LG
4 cytokine activity GO:0005125 9.4 TNF THPO TGFB1 IL6 IL1RN IL1B
5 tumor necrosis factor receptor binding GO:0005164 9.33 TNF FASLG CD40LG
6 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Idiopathic Neutropenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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