MCID: IDP064
MIFTS: 46

Idiopathic Neutropenia

Categories: Rare diseases

Aliases & Classifications for Idiopathic Neutropenia

MalaCards integrated aliases for Idiopathic Neutropenia:

Name: Idiopathic Neutropenia 53 73
Nonimmune Chronic Idiopathic Neutropenia of Adults 53
Neutropenia, Nonimmune Chronic Idiopathic, Adult 73
Ni-Cina 53

Classifications:



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Summaries for Idiopathic Neutropenia

NIH Rare Diseases : 53 Idiopathic neutropenia is an acquired form of severe chronic neutropenia whose cause is unknown. Neutropenia is a blood condition that causes a reduced number or complete absence of neutrophils, a type of white blood cell that is responsible for much of the body's protection against infection. Symptoms include fever, moth sores, and other types of infections. Neutropenia idiopathic may occur in children and adults. Frequency and severity of infections appear to be directly related to neutrophil count; while clinical problems in individual patients may vary, in general, those patients with more severe neutropenia have more frequent infections. Most patients respond well to granulocyte-colony stimulating factor (G-CSF). Long-term treatment is usually required.  

MalaCards based summary : Idiopathic Neutropenia, also known as nonimmune chronic idiopathic neutropenia of adults, is related to helicobacter pylori infection and gingival overgrowth. An important gene associated with Idiopathic Neutropenia is GFI1 (Growth Factor Independent 1 Transcriptional Repressor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include neutrophil, bone and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Idiopathic Neutropenia

Diseases related to Idiopathic Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
# Related Disease Score Top Affiliating Genes
1 helicobacter pylori infection 30.2 CASP3 CCL5 IL1B
2 gingival overgrowth 29.8 IL1A IL6 TGFB1
3 leukemia, acute myeloid 29.8 CASP3 CSF3R GFI1 THPO TNF
4 relapsing-remitting multiple sclerosis 29.7 CCL5 IL10 TNF
5 gingivitis 29.5 IL1A IL1B IL6 TNF
6 cytomegalovirus infection 29.5 CASP3 CCL5 IL1B IL6 TNF
7 aplastic anemia 29.2 CSF3R FASLG HLA-DRB1 IL6 THPO TNF
8 osteoporosis 29.0 IL1A IL1B IL1RN IL6 TGFB1 TNF
9 periodontitis 28.8 IL10 IL1A IL1B IL6 TLR4 TNF
10 multiple sclerosis 28.8 CCL5 HLA-DRB1 IL10 IL1B IL2RA IL6
11 neutropenia, nonimmune chronic idiopathic, of adults 12.1
12 neutropenia 10.8
13 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
14 diabetic foot ulcers 10.3 IL6 TGFB1
15 leukomalacia 10.3 IL6 TNF
16 obesity-hypoventilation syndrome 10.3 CCL5 IL6
17 type ii mixed cryoglobulinemia 10.3 FASLG HLA-DRB1
18 inclusion conjunctivitis 10.3 CCL5 HMGB1 TNF
19 exudative glomerulonephritis 10.3 IL1B TNF
20 rheumatoid factor-negative juvenile idiopathic arthritis 10.3 HLA-DRB1 IL2RA
21 trench fever 10.2 TLR4 TNF
22 systemic onset juvenile idiopathic arthritis 10.2 IL1RN TNF
23 pulmonary sarcoidosis 10.2 CCL5 IL2RA TNF
24 idiopathic inflammatory myopathy 10.2 HLA-DRB1 IL1A
25 end stage renal failure 10.2 IL6 TGFB1 TNF
26 urinary system disease 10.2 IL6 TGFB1 TNF
27 localized scleroderma 10.2 IL6 TGFB1 TNF
28 rasmussen encephalitis 10.2 HMGB1 IL6 TNF
29 mesial temporal lobe epilepsy with hippocampal sclerosis 10.2 HLA-DRB1 IL1B
30 myocarditis 10.2 CD40LG IL6 TNF
31 recurrent corneal erosion 10.2 IL1B IL6
32 bagassosis 10.2 IL1B IL6
33 iga glomerulonephritis 10.2 CD40LG IL6 TGFB1
34 meningoencephalitis 10.2 CCL5 CD40LG IL6
35 reproductive system disease 10.2 CASP3 IL6 TNF
36 paraneoplastic syndromes 10.2 IL1B IL6
37 female reproductive system disease 10.2 CASP3 IL6 TNF
38 gastrointestinal system cancer 10.2 CASP3 IL6 TNF
39 leukocyte disease 10.2 CASP3 IL6 TNF
40 mumps 10.2 HLA-DRB1 IL2RA TNF
41 chronic follicular conjunctivitis 10.2 IL1A IL1B
42 neuritis 10.2 CCL5 IL1B TNF
43 scorpion envenomation 10.2 CCL5 IL6 TNF
44 takayasu arteritis 10.2 HLA-DRB1 IL6 TNF
45 hemorrhagic fever with renal syndrome 10.2 HLA-DRB1 IL6 TNF
46 oral lichen planus 10.2 CASP3 CCL5 IL1A
47 cholangitis 10.2 HLA-DRB1 IL6 TNF
48 breast disease 10.2 CASP3 FASLG TGFB1 TNF
49 prosthetic joint infection 10.1 IL1B TLR4
50 palindromic rheumatism 10.1 HLA-DRB1 IL1B TNF

Graphical network of the top 20 diseases related to Idiopathic Neutropenia:



Diseases related to Idiopathic Neutropenia

Symptoms & Phenotypes for Idiopathic Neutropenia

GenomeRNAi Phenotypes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CASP3 CD40LG IL10 IL1A IL1B IL2RA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CASP3 CD40LG IL10 IL1A IL1B IL2RA
3 Decreased viability with paclitaxel GR00179-A-1 9.26 CASP3 IL10 TGFB1
4 Decreased viability with paclitaxel GR00179-A-3 9.26 TGFB1

MGI Mouse Phenotypes related to Idiopathic Neutropenia:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.42 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
2 immune system MP:0005387 10.39 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
3 cardiovascular system MP:0005385 10.33 CASP3 CD40LG CSF3R FASLG IL10 IL1A
4 homeostasis/metabolism MP:0005376 10.32 CASP3 CD40LG FASLG FCER2 IL10 IL1A
5 cellular MP:0005384 10.31 CASP3 CD40LG CSF3R FASLG FCER2 GFI1
6 mortality/aging MP:0010768 10.25 CASP3 CD40LG CSF3R FASLG FCER2 GFI1
7 endocrine/exocrine gland MP:0005379 10.21 CASP3 CD40LG CSF3R FASLG GFI1 IL10
8 digestive/alimentary MP:0005381 10.18 CASP3 FASLG FCER2 IL10 IL2RA IL6
9 integument MP:0010771 10.17 CASP3 CD40LG FASLG IL10 IL1A IL1B
10 nervous system MP:0003631 10.06 CASP3 CD40LG CSF3R FASLG GFI1 IL10
11 neoplasm MP:0002006 9.97 FASLG IL10 IL1A IL1B IL6 TGFB1
12 reproductive system MP:0005389 9.96 CASP3 CD40LG CSF3R FASLG IL10 IL1RN
13 respiratory system MP:0005388 9.76 CASP3 FASLG IL10 IL2RA IL6 TGFB1
14 skeleton MP:0005390 9.65 CASP3 CD40LG FASLG IL10 IL1B IL1RN
15 vision/eye MP:0005391 9.23 CASP3 FASLG IL10 IL2RA IL6 TGFB1

Drugs & Therapeutics for Idiopathic Neutropenia

Search Clinical Trials , NIH Clinical Center for Idiopathic Neutropenia

Genetic Tests for Idiopathic Neutropenia

Anatomical Context for Idiopathic Neutropenia

MalaCards organs/tissues related to Idiopathic Neutropenia:

41
Neutrophil, Bone, Bone Marrow, Myeloid, Liver, B Cells, Lung

Publications for Idiopathic Neutropenia

Articles related to Idiopathic Neutropenia:

(show top 50) (show all 103)
# Title Authors Year
1
Idiopathic neutropenia of infancy: data from the Italian Neutropenia Registry. ( 30456824 )
2018
2
An update on the diagnosis and treatment of chronic idiopathic neutropenia. ( 27841775 )
2017
3
Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors. ( 28535087 )
2017
4
Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia. ( 28732781 )
2017
5
Minor populations of paroxysmal nocturnal haemoglobinuria type cells in patients with chronic idiopathic neutropenia. ( 27124520 )
2016
6
Association between helicobacter pylori infection and chronic idiopathic neutropenia. ( 23771659 )
2013
7
Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination. ( 23417376 )
2013
8
Infectious complications in children with severe congenital, autoimmune or idiopathic neutropenia: a retrospective study from the Italian Neutropenia Registry. ( 23249920 )
2013
9
An acquired CSF3R mutation in an adult chronic idiopathic neutropenia patient who developed acute myeloid leukaemia. ( 22146088 )
2012
10
Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia. ( 22133767 )
2012
11
Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia. ( 22956967 )
2012
12
Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia. ( 22875614 )
2012
13
Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. ( 22092365 )
2012
14
Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4. ( 22127462 )
2012
15
Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-I^1. ( 21047210 )
2011
16
T-cell receptor VI^ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. ( 20864416 )
2010
17
Idiopathic neutropenia with fewer than 5% dysplasia may be a distinct entity of idiopathic cytopenia of undetermined significance. ( 19823822 )
2010
18
Case history: individualized homeopathy and severe chronic idiopathic neutropenia (SCN). ( 20674845 )
2010
19
The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. ( 19614955 )
2009
20
Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. ( 21082926 )
2008
21
Idiopathic neutropenia of childhood is associated with Fas/FasL expression. ( 18819843 )
2008
22
Normal levels of constitutive and death receptor-mediated apoptosis of peripheral blood neutrophils from patients with chronic idiopathic neutropenia. ( 17188576 )
2007
23
Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia. ( 17961177 )
2007
24
Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. ( 16432851 )
2006
25
Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. ( 16982324 )
2006
26
Pro-inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin-10. ( 17054669 )
2006
27
Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. ( 16391909 )
2006
28
Increased levels of soluble flt-3 ligand in serum and long-term bone marrow culture supernatants in patients with chronic idiopathic neutropenia. ( 16445839 )
2006
29
Evaluation of clinicopathologic features, response to treatment, and risk factors associated with idiopathic neutropenia in dogs: 11 cases (1990-2002). ( 16817719 )
2006
30
Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow. ( 16938119 )
2006
31
Lactate dehydrogenase-linked immunoglobulin Akappa in a patient with nonimmune chronic idiopathic neutropenia. ( 16950676 )
2006
32
Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults. ( 15986200 )
2005
33
High prevalence of Helicobacter pylori infection and monoclonal gammopathy of undetermined significance in patients with chronic idiopathic neutropenia. ( 15731921 )
2005
34
Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia. ( 15755293 )
2005
35
Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis. ( 15490268 )
2004
36
Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia. ( 15014900 )
2004
37
Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute myeloid leukemia. ( 15338195 )
2004
38
Recovery of neutrophil count by ganciclovir in patients with chronic idiopathic neutropenia associated with cytomegalovirus infection in bone marrow stromal cells. ( 15218961 )
2004
39
Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. ( 12517813 )
2003
40
Low levels of serum elastase are not associated with mutations in ELA-2 elastase encoding gene in chronic idiopathic neutropenia. ( 12642348 )
2003
41
Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia. ( 12904900 )
2003
42
Low serum gamma-glutamyltranspeptidase (GGT) in patients with chronic idiopathic neutropenia is not implicated in the pathophysiology of the disease. ( 14607768 )
2003
43
Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor. ( 11807637 )
2002
44
Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. ( 11202431 )
2001
45
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy. ( 11737689 )
2001
46
Patients with non-immune chronic idiopathic neutropenia syndrome have increased splenic volume on ultrasonography. ( 11488850 )
2001
47
Increased frequency and specific reactivity of serum antinuclear antibodies in patients with nonimmune chronic idiopathic neutropenia of adults. ( 11340248 )
2001
48
Increased frequency of monoclonal gammopathy of undetermined significance in patients with nonimmune chronic idiopathic neutropenia syndrome. ( 11345200 )
2001
49
Anemia of chronic disease is the more frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults. ( 11401084 )
2001
50
Chronic idiopathic neutropenia associated with gingival enlargement. ( 11432499 )
2001

Variations for Idiopathic Neutropenia

Expression for Idiopathic Neutropenia

Search GEO for disease gene expression data for Idiopathic Neutropenia.

Pathways for Idiopathic Neutropenia

Pathways related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
2
Show member pathways
13.97 CASP3 CCL5 CD40LG CSF3R FASLG IL10
3
Show member pathways
13.7 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
4
Show member pathways
13.63 CCL5 IL10 IL1A IL1B IL2RA IL6
5
Show member pathways
13.49 CASP3 CCL5 CD40LG CSF3R FASLG IL10
6
Show member pathways
13.4 CASP3 CCL5 CD40LG CSF3R FASLG IL10
7
Show member pathways
13.32 FCER2 HLA-DRB1 HMGB1 IL1A IL1B IL2RA
8
Show member pathways
13.24 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
9
Show member pathways
13.19 CASP3 CCL5 FASLG IL1B IL6 TGFB1
10
Show member pathways
13.15 CCL5 FASLG IL10 IL1B IL6 TGFB1
11
Show member pathways
13.1 CASP3 CSF3R FASLG IL2RA IL6 TLR4
12
Show member pathways
13.03 CASP3 CD40LG FASLG HLA-DRB1 IL10 IL1A
13
Show member pathways
12.95 CASP3 CCL5 FASLG HLA-DRB1 IL1A IL1B
14 12.94 CASP3 CSF3R FASLG IL2RA IL6 TGFB1
15 12.88 CASP3 FASLG IL1A IL1B TGFB1 TNF
16
Show member pathways
12.88 CD40LG IL1A IL1B IL6 TGFB1 THPO
17
Show member pathways
12.87 CCL5 HMGB1 IL1B IL6 TLR4 TNF
18
Show member pathways
12.8 CASP3 CD40LG FASLG IL1A IL1B TNF
19
Show member pathways
12.78 HLA-DRB1 IL10 IL1A IL1B IL2RA IL6
20
Show member pathways
12.77 CASP3 CD40LG FASLG IL1A IL1B TLR4
21 12.74 CCL5 CD40LG FASLG IL10 IL1B IL1RN
22
Show member pathways
12.72 CD40LG HLA-DRB1 IL10 IL2RA TNF
23
Show member pathways
12.62 CD40LG IL10 IL1A IL1B IL6 TGFB1
24 12.54 HLA-DRB1 IL2RA IL6 TGFB1 TNF
25
Show member pathways
12.51 CSF3R IL10 IL2RA IL6 THPO
26
Show member pathways
12.49 CASP3 IL1A IL1B IL2RA
27
Show member pathways
12.45 IL10 IL1A IL1B IL2RA IL6 TGFB1
28
Show member pathways
12.43 IL1A IL1B IL6 TLR4 TNF
29 12.42 CASP3 FCER2 HLA-DRB1 IL6 TNF
30
Show member pathways
12.41 CCL5 IL1B IL6 TNF
31 12.41 CASP3 FASLG TGFB1 TLR4 TNF
32
Show member pathways
12.4 CASP3 IL1B IL6 TNF
33
Show member pathways
12.39 FASLG HMGB1 IL1A IL1B TLR4 TNF
34 12.38 CASP3 IL10 IL1A IL1B IL1RN IL6
35
Show member pathways
12.36 IL1A IL1B IL1RN IL6 TNF
36
Show member pathways
12.36 CASP3 CD40LG HLA-DRB1 IL10 IL1A IL1B
37
Show member pathways
12.34 IL1A IL6 TLR4 TNF
38
Show member pathways
12.33 CASP3 FASLG IL1A TNF
39 12.33 CASP3 CD40LG FASLG TNF
40
Show member pathways
12.32 FASLG IL1B IL6 TLR4 TNF
41 12.32 CASP3 IL6 TGFB1 TLR4 TNF
42
Show member pathways
12.3 IL10 IL1B IL6 TNF
43 12.27 CASP3 HLA-DRB1 IL10 IL1A IL1B IL6
44
Show member pathways
12.26 CCL5 IL10 IL1A IL1B IL2RA IL6
45
Show member pathways
12.25 IL10 IL1B IL6 TGFB1 TLR4 TNF
46 12.23 CASP3 IL1A IL1B IL6 TGFB1 TLR4
47
Show member pathways
12.2 HMGB1 IL1B IL6 TLR4 TNF
48 12.2 CSF3R IL10 IL2RA IL6 THPO TNF
49
Show member pathways
12.19 FASLG IL10 IL6 TGFB1
50 12.16 IL1A IL1B TGFB1 TNF

GO Terms for Idiopathic Neutropenia

Cellular components related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.93 CCL5 CD40LG FASLG HMGB1 IL10 IL1A
2 cell surface GO:0009986 9.86 CD40LG FASLG HLA-DRB1 HMGB1 IL2RA TGFB1
3 external side of plasma membrane GO:0009897 9.56 CD40LG CSF3R FASLG FCER2 HLA-DRB1 IL2RA
4 extracellular region GO:0005576 9.47 CCL5 CD40LG CSF3R FASLG FCER2 HMGB1

Biological processes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.98 IL10 IL1B IL6 TNF
2 response to organic substance GO:0010033 9.96 CASP3 IL10 TGFB1 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 CD40LG IL1B IL6 TGFB1 TLR4 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.95 GFI1 IL10 IL1B IL1RN IL6 TLR4
5 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.94 CASP3 FASLG TNF
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.94 IL6 TGFB1 TNF
7 neutrophil chemotaxis GO:0030593 9.94 CCL5 CSF3R IL1B IL1RN
8 cellular response to mechanical stimulus GO:0071260 9.93 IL1B TGFB1 TLR4
9 tumor necrosis factor-mediated signaling pathway GO:0033209 9.93 CD40LG FASLG TNF
10 regulation of insulin secretion GO:0050796 9.93 CCL5 IL1B TNF
11 positive regulation of JNK cascade GO:0046330 9.93 HMGB1 IL1B IL1RN TLR4 TNF
12 immune response GO:0006955 9.93 CCL5 CD40LG FASLG HLA-DRB1 IL10 IL1A
13 apoptotic signaling pathway GO:0097190 9.92 CASP3 FASLG TLR4 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 CCL5 IL6 TNF
15 interleukin-1-mediated signaling pathway GO:0070498 9.91 IL1A IL1B IL1RN
16 cellular response to organic cyclic compound GO:0071407 9.91 CASP3 CCL5 IL1B TGFB1 TNF
17 negative regulation of fat cell differentiation GO:0045599 9.9 IL6 TGFB1 TNF
18 positive regulation of neuron apoptotic process GO:0043525 9.9 CASP3 FASLG IL1B
19 positive regulation of cell division GO:0051781 9.9 IL1A IL1B TGFB1
20 extrinsic apoptotic signaling pathway GO:0097191 9.89 FASLG TGFB1 TNF
21 positive regulation of interferon-gamma production GO:0032729 9.89 IL1B TLR4 TNF
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.89 IL1B TLR4 TNF
23 positive regulation of JUN kinase activity GO:0043507 9.89 IL1B IL1RN TNF
24 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 HMGB1 IL1B TLR4 TNF
25 positive regulation of T cell proliferation GO:0042102 9.89 CCL5 CD40LG IL1B IL2RA IL6
26 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.88 IL1A IL1B TNF
27 negative regulation of mitotic cell cycle GO:0045930 9.88 IL10 TGFB1 TNF
28 negative regulation of T cell proliferation GO:0042130 9.88 HLA-DRB1 IL10 IL2RA TGFB1
29 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.87 CASP3 IL1A IL1B
30 protein kinase B signaling GO:0043491 9.87 CCL5 IL1B TGFB1 TNF
31 response to glucocorticoid GO:0051384 9.87 CASP3 HMGB1 IL10 IL1B IL1RN IL6
32 negative regulation of interleukin-6 production GO:0032715 9.86 IL10 TLR4 TNF
33 T cell homeostasis GO:0043029 9.86 CASP3 IL2RA TGFB1
34 positive regulation of cytokine secretion GO:0050715 9.85 IL10 IL1A TNF
35 positive regulation of interleukin-8 production GO:0032757 9.85 IL1B TLR4 TNF
36 positive regulation of vascular endothelial growth factor production GO:0010575 9.85 IL1A IL1B TGFB1
37 negative regulation of neurogenesis GO:0050768 9.85 IL1B IL6 TNF
38 negative regulation of interferon-gamma production GO:0032689 9.85 HLA-DRB1 HMGB1 IL10 TLR4
39 positive regulation of interleukin-6 production GO:0032755 9.85 HMGB1 IL1B IL1RN IL6 TLR4 TNF
40 positive regulation of interleukin-12 production GO:0032735 9.84 CD40LG HMGB1 TLR4
41 positive regulation of interleukin-10 production GO:0032733 9.84 CD40LG HMGB1 TLR4
42 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 CCL5 IL1B TGFB1 TLR4 TNF
43 positive regulation of chemokine production GO:0032722 9.82 IL6 TLR4 TNF
44 positive regulation of glial cell proliferation GO:0060252 9.81 IL1B IL6 TNF
45 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 IL10 IL1B TNF
46 inflammatory response to antigenic stimulus GO:0002437 9.77 HLA-DRB1 HMGB1 IL2RA
47 cytokine-mediated signaling pathway GO:0019221 9.77 CASP3 CCL5 CSF3R FASLG FCER2 IL10
48 positive regulation of interferon-alpha production GO:0032727 9.76 HMGB1 TLR4
49 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.76 IL1A IL1B
50 negative regulation of interleukin-17 production GO:0032700 9.76 TGFB1 TLR4

Molecular functions related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.62 IL10 IL6 TGFB1 THPO
2 cytokine activity GO:0005125 9.4 CCL5 CD40LG FASLG HMGB1 IL10 IL1A
3 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG FASLG TNF
4 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
5 protein binding GO:0005515 10.19 CASP3 CCL5 CD40LG CSF3R FASLG FCER2

Sources for Idiopathic Neutropenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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44 MeSH
45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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