MCID: IDP064
MIFTS: 44

Idiopathic Neutropenia

Categories: Rare diseases

Aliases & Classifications for Idiopathic Neutropenia

MalaCards integrated aliases for Idiopathic Neutropenia:

Name: Idiopathic Neutropenia 53 73
Nonimmune Chronic Idiopathic Neutropenia of Adults 53
Neutropenia, Nonimmune Chronic Idiopathic, Adult 73
Ni-Cina 53

Classifications:



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Summaries for Idiopathic Neutropenia

NIH Rare Diseases : 53 Idiopathic neutropenia is an acquired form of severe chronic neutropenia whose cause is unknown. Neutropenia is a blood condition that causes a reduced number or complete absence of neutrophils, a type of white blood cell that is responsible for much of the body's protection against infection. Symptoms include fever, moth sores, and other types of infections. Neutropenia idiopathic may occur in children and adults. Frequency and severity of infections appear to be directly related to neutrophil count; while clinical problems in individual patients may vary, in general, those patients with more severe neutropenia have more frequent infections. Most patients respond well to granulocyte-colony stimulating factor (G-CSF). Long-term treatment is usually required.  

MalaCards based summary : Idiopathic Neutropenia, also known as nonimmune chronic idiopathic neutropenia of adults, is related to neutropenia and relapsing-remitting multiple sclerosis. An important gene associated with Idiopathic Neutropenia is GFI1 (Growth Factor Independent 1 Transcriptional Repressor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include neutrophil, bone and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Idiopathic Neutropenia

Diseases related to Idiopathic Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 296)
# Related Disease Score Top Affiliating Genes
1 neutropenia 30.5 CSF3R FASLG GFI1 THPO
2 relapsing-remitting multiple sclerosis 29.6 CCL5 IL10 TNF
3 osteoporosis 29.2 IL1A IL1B IL1RN IL6 TGFB1 TNF
4 leukemia, acute myeloid 28.4 CASP3 CSF3R GFI1 THPO TNF
5 temporal arteritis 28.1 CCL5 CD40LG HLA-DRB1 IL1RN IL6
6 aplastic anemia 28.0 CSF3R FASLG HLA-DRB1 IL6 THPO TNF
7 multiple sclerosis 27.8 CCL5 HLA-DRB1 IL10 IL1B IL2RA IL6
8 helicobacter pylori infection 26.7 CASP3 CCL5 HLA-DRB1 IL10 IL1B IL1RN
9 neutropenia, nonimmune chronic idiopathic, of adults 12.0
10 punctate inner choroidopathy 11.0 IL10 TNF
11 tropical endomyocardial fibrosis 10.9 IL10 TNF
12 systemic onset juvenile idiopathic arthritis 10.9 IL1B TNF
13 inflammatory bowel disease 25, autosomal recessive 10.9 IL10 TGFB1
14 prosthetic joint infection 10.8 IL1B TLR4
15 vulvar vestibulitis syndrome 10.8 IL1B IL1RN TNF
16 cerebral artery occlusion 10.8 IL1B IL1RN TNF
17 chronic follicular conjunctivitis 10.8 IL1A IL1B
18 clonorchiasis 10.8 IL10 TGFB1 TNF
19 leukomalacia 10.8 IL6 TNF
20 hyperlucent lung 10.8 IL10 IL2RA
21 recurrent corneal erosion 10.8 IL1B IL6
22 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
23 irritant dermatitis 10.7 IL1A IL1B TNF
24 posterior urethral valves 10.7 IL6 TGFB1 TNF
25 acute vascular insufficiency of intestine 10.7 IL1B IL6 TNF
26 poems syndrome 10.7 IL1B IL6 TNF
27 autoimmune myocarditis 10.7 IL1B TNF
28 staphylococcal toxic shock syndrome 10.7 HMGB1 IL1B TNF
29 pouchitis 10.7 IL10 IL1RN TLR4
30 bagassosis 10.7 IL1B IL6
31 duodenal ulcer 10.7 IL1B IL1RN TNF
32 localized scleroderma 10.7 IL6 TGFB1 TNF
33 extrapulmonary tuberculosis 10.7 IL10 IL1B IL1RN
34 endometritis 10.7 IL1B IL6 TNF
35 familial mediterranean fever 10.7 IL1B IL1RN TNF
36 stromal keratitis 10.7 IL2RA IL6 TNF
37 pulmonary edema 10.7 IL10 IL1B TNF
38 gingival disease 10.7 IL1B IL6 TGFB1
39 allergic contact dermatitis 10.7 IL10 IL1B TNF
40 multidrug-resistant tuberculosis 10.7 IL10 IL1A TNF
41 root resorption 10.6 IL1A IL1B IL1RN
42 acute respiratory distress syndrome 10.6 IL1B IL6 TNF
43 chronic graft versus host disease 10.6 IL10 IL1A IL2RA
44 listeriosis 10.6 IL10 IL6 TNF
45 transverse myelitis 10.6 IL10 IL6 TNF
46 pericarditis 10.6 IL1B IL6 TNF
47 hydrarthrosis 10.6 IL1B IL1RN IL6
48 endometrial disease 10.6 IL1B IL6 TLR4
49 funisitis 10.6 IL10 IL1B IL6
50 cysticercosis 10.6 IL1B IL6 TLR4

Graphical network of the top 20 diseases related to Idiopathic Neutropenia:



Diseases related to Idiopathic Neutropenia

Symptoms & Phenotypes for Idiopathic Neutropenia

GenomeRNAi Phenotypes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 IL1B IL2RA TGFB1 CASP3 TNF CD40LG
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 IL1B IL2RA TGFB1 CASP3 TNF CD40LG
3 Decreased viability with paclitaxel GR00179-A-1 9.26 TGFB1 CASP3 IL10
4 Decreased viability with paclitaxel GR00179-A-3 9.26 TGFB1

MGI Mouse Phenotypes related to Idiopathic Neutropenia:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.42 FCER2 CSF3R CASP3 FASLG CCL5 CD40LG
2 immune system MP:0005387 10.39 FCER2 CSF3R CASP3 FASLG CCL5 CD40LG
3 cardiovascular system MP:0005385 10.33 CSF3R CASP3 FASLG CD40LG IL1A IL1B
4 homeostasis/metabolism MP:0005376 10.32 CD40LG FCER2 CASP3 FASLG IL1A IL1B
5 cellular MP:0005384 10.31 CD40LG FCER2 CSF3R CASP3 FASLG GFI1
6 mortality/aging MP:0010768 10.25 CD40LG FCER2 CSF3R CASP3 FASLG IL2RA
7 endocrine/exocrine gland MP:0005379 10.21 CD40LG CSF3R CASP3 FASLG IL2RA GFI1
8 digestive/alimentary MP:0005381 10.18 FCER2 CASP3 FASLG IL10 IL2RA IL6
9 integument MP:0010771 10.17 CASP3 FASLG CD40LG IL1A IL6 IL1B
10 nervous system MP:0003631 10.06 CD40LG CSF3R CASP3 FASLG GFI1 IL1B
11 neoplasm MP:0002006 9.97 FASLG IL1A IL1B IL10 TNF IL6
12 reproductive system MP:0005389 9.96 CD40LG CSF3R CASP3 FASLG IL1RN IL10
13 respiratory system MP:0005388 9.76 CASP3 FASLG IL2RA IL10 TGFB1 IL6
14 skeleton MP:0005390 9.65 CD40LG CASP3 FASLG IL1B IL1RN IL10
15 vision/eye MP:0005391 9.23 FASLG CASP3 IL2RA IL10 TGFB1 IL6

Drugs & Therapeutics for Idiopathic Neutropenia

Search Clinical Trials , NIH Clinical Center for Idiopathic Neutropenia

Genetic Tests for Idiopathic Neutropenia

Anatomical Context for Idiopathic Neutropenia

MalaCards organs/tissues related to Idiopathic Neutropenia:

41
Neutrophil, Bone, Bone Marrow, Myeloid, T Cells, B Cells

Publications for Idiopathic Neutropenia

Articles related to Idiopathic Neutropenia:

(show all 40)
# Title Authors Year
1
An update on the diagnosis and treatment of chronic idiopathic neutropenia. ( 27841775 )
2017
2
Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors. ( 28535087 )
2017
3
Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia. ( 28732781 )
2017
4
Minor populations of paroxysmal nocturnal haemoglobinuria type cells in patients with chronic idiopathic neutropenia. ( 27124520 )
2016
5
Association between helicobacter pylori infection and chronic idiopathic neutropenia. ( 23771659 )
2013
6
Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination. ( 23417376 )
2013
7
Infectious complications in children with severe congenital, autoimmune or idiopathic neutropenia: a retrospective study from the Italian Neutropenia Registry. ( 23249920 )
2013
8
An acquired CSF3R mutation in an adult chronic idiopathic neutropenia patient who developed acute myeloid leukaemia. ( 22146088 )
2012
9
Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia. ( 22133767 )
2012
10
Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia. ( 22956967 )
2012
11
Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia. ( 22875614 )
2012
12
Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. ( 22092365 )
2012
13
Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4. ( 22127462 )
2012
14
Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-I^1. ( 21047210 )
2011
15
T-cell receptor VI^ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. ( 20864416 )
2010
16
Idiopathic neutropenia with fewer than 5% dysplasia may be a distinct entity of idiopathic cytopenia of undetermined significance. ( 19823822 )
2010
17
Case history: individualized homeopathy and severe chronic idiopathic neutropenia (SCN). ( 20674845 )
2010
18
The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. ( 19614955 )
2009
19
Chronic idiopathic neutropenias and severe congenital neutropenia. ( 18043240 )
2008
20
Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. ( 21082926 )
2008
21
Idiopathic neutropenia of childhood is associated with Fas/FasL expression. ( 18819843 )
2008
22
Normal levels of constitutive and death receptor-mediated apoptosis of peripheral blood neutrophils from patients with chronic idiopathic neutropenia. ( 17188576 )
2007
23
Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia. ( 17961177 )
2007
24
Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. ( 16432851 )
2006
25
Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. ( 16982324 )
2006
26
Pro-inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin-10. ( 17054669 )
2006
27
Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. ( 16391909 )
2006
28
Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow. ( 16938119 )
2006
29
Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults. ( 15986200 )
2005
30
Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis. ( 15490268 )
2004
31
Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia. ( 15014900 )
2004
32
Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute myeloid leukemia. ( 15338195 )
2004
33
Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor. ( 11807637 )
2002
34
Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. ( 11202431 )
2001
35
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy. ( 11737689 )
2001
36
Patients with non-immune chronic idiopathic neutropenia syndrome have increased splenic volume on ultrasonography. ( 11488850 )
2001
37
Increased serum IgA and decreased IgG3 strongly correlate with increased serum TGF-beta1 levels in patients with nonimmune chronic idiopathic neutropenia of adults. ( 11073164 )
2000
38
Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines. ( 11074551 )
2000
39
Prevention of infection in a patient with chronic idiopathic neutropenia undergoing coronary bypass surgery with peri-operative G-CSF. ( 8996068 )
1996
40
G-CSF in the long-term treatment of cyclic neutropenia and chronic idiopathic neutropenia in adult patients. ( 8589368 )
1995

Variations for Idiopathic Neutropenia

Expression for Idiopathic Neutropenia

Search GEO for disease gene expression data for Idiopathic Neutropenia.

Pathways for Idiopathic Neutropenia

Pathways related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
2
Show member pathways
13.96 CASP3 CCL5 CD40LG CSF3R FASLG IL10
3
Show member pathways
13.7 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
4
Show member pathways
13.6 CCL5 IL10 IL1A IL1B IL2RA IL6
5
Show member pathways
13.49 CASP3 CCL5 CD40LG CSF3R FASLG IL10
6
Show member pathways
13.39 CASP3 CCL5 CD40LG CSF3R FASLG IL10
7
Show member pathways
13.14 CCL5 FASLG IL10 IL1B IL6 TGFB1
8
Show member pathways
13.14 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
9
Show member pathways
13.08 CASP3 CSF3R FASLG IL2RA IL6 TLR4
10
Show member pathways
13.03 CASP3 CD40LG FASLG HLA-DRB1 IL10 IL1A
11
Show member pathways
12.96 CASP3 CCL5 FASLG HLA-DRB1 IL1A IL1B
12
Show member pathways
12.95 CASP3 CCL5 FASLG IL6 TNF
13 12.93 CASP3 CSF3R FASLG IL2RA IL6 TGFB1
14
Show member pathways
12.89 HMGB1 IL1A IL1B IL2RA TLR4 TNF
15 12.87 CASP3 FASLG IL1A IL1B TGFB1 TNF
16
Show member pathways
12.87 CD40LG IL1A IL1B IL6 TGFB1 THPO
17
Show member pathways
12.86 CCL5 HMGB1 IL1B IL6 TLR4 TNF
18
Show member pathways
12.81 CSF3R IL10 IL1A IL1B IL2RA IL6
19
Show member pathways
12.78 CASP3 CD40LG FASLG IL1A IL1B TNF
20 12.74 CCL5 CD40LG FASLG IL10 IL1B IL1RN
21
Show member pathways
12.69 CASP3 FASLG IL6 TGFB1 TLR4 TNF
22
Show member pathways
12.69 CASP3 CD40LG FASLG IL1A IL1B TLR4
23
Show member pathways
12.61 CD40LG IL10 IL1A IL1B IL6 TGFB1
24
Show member pathways
12.61 HLA-DRB1 IL10 IL1A IL1B IL2RA IL6
25 12.53 HLA-DRB1 IL2RA IL6 TGFB1 TNF
26
Show member pathways
12.49 CASP3 IL1A IL1B IL2RA
27
Show member pathways
12.43 IL10 IL1B IL6 TGFB1 TLR4 TNF
28 12.41 CASP3 FASLG TGFB1 TLR4 TNF
29
Show member pathways
12.4 CCL5 IL1B IL6 TNF
30
Show member pathways
12.4 CASP3 IL1B IL6 TNF
31
Show member pathways
12.4 IL1A IL1B IL6 TLR4 TNF
32
Show member pathways
12.38 FASLG HMGB1 IL1A IL1B TLR4 TNF
33 12.36 CASP3 IL10 IL1A IL1B IL1RN IL6
34
Show member pathways
12.36 CASP3 CD40LG HLA-DRB1 IL10 IL1A IL1B
35
Show member pathways
12.35 IL1A IL1B IL1RN IL6 TNF
36
Show member pathways
12.34 IL1A IL6 TLR4 TNF
37 12.32 CASP3 CD40LG FASLG TNF
38
Show member pathways
12.32 FASLG IL1B IL6 TLR4 TNF
39 12.31 CASP3 IL6 TGFB1 TLR4 TNF
40
Show member pathways
12.3 CASP3 FASLG IL1A TNF
41
Show member pathways
12.29 IL10 IL1B IL6 TNF
42 12.27 CASP3 HLA-DRB1 IL10 IL1A IL1B IL6
43
Show member pathways
12.25 CCL5 IL10 IL1A IL1B IL2RA IL6
44 12.21 CASP3 IL1A IL1B IL6 TGFB1 TLR4
45 12.19 CSF3R IL10 IL2RA IL6 THPO TNF
46
Show member pathways
12.18 FASLG IL10 IL6 TGFB1
47 12.15 IL1A IL1B TGFB1 TNF
48 12.14 FASLG FCER2 IL10 IL1A IL1B IL6
49
Show member pathways
12.13 IL1A IL1B IL2RA TLR4
50 12.12 CASP3 CCL5 IL1B IL6 TNF

GO Terms for Idiopathic Neutropenia

Cellular components related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.86 CD40LG FASLG HLA-DRB1 HMGB1 IL2RA TGFB1
2 extracellular space GO:0005615 9.73 CCL5 CD40LG FASLG HMGB1 IL10 IL1A
3 external side of plasma membrane GO:0009897 9.7 CD40LG FASLG FCER2 HLA-DRB1 IL2RA TLR4
4 extracellular region GO:0005576 9.47 CCL5 CD40LG CSF3R FASLG FCER2 HMGB1

Biological processes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding transcription factor activity GO:0051091 9.98 IL10 IL1B IL6 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.98 GFI1 IL10 IL6 TLR4 TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CCL5 HMGB1 IL1A TGFB1 THPO TLR4
4 cytokine-mediated signaling pathway GO:0019221 9.97 CASP3 CCL5 CSF3R FASLG FCER2 IL10
5 response to organic substance GO:0010033 9.96 CASP3 IL10 TGFB1 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 CD40LG IL1B IL6 TGFB1 TLR4 TNF
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.93 CASP3 FASLG TNF
8 apoptotic signaling pathway GO:0097190 9.93 CASP3 FASLG TLR4 TNF
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.92 IL6 TGFB1 TNF
10 cellular response to mechanical stimulus GO:0071260 9.92 IL1B TGFB1 TLR4
11 regulation of insulin secretion GO:0050796 9.92 CCL5 IL1B TNF
12 cellular response to organic cyclic compound GO:0071407 9.92 CASP3 CCL5 IL1B TGFB1 TNF
13 neutrophil chemotaxis GO:0030593 9.91 CCL5 CSF3R IL1B
14 positive regulation of JNK cascade GO:0046330 9.91 HMGB1 IL1A IL1B TLR4 TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 CCL5 IL6 TNF
16 positive regulation of cell division GO:0051781 9.89 IL1A IL1B TGFB1
17 negative regulation of fat cell differentiation GO:0045599 9.89 IL6 TGFB1 TNF
18 extrinsic apoptotic signaling pathway GO:0097191 9.89 FASLG TGFB1 TNF
19 positive regulation of T cell proliferation GO:0042102 9.89 CCL5 CD40LG IL1B IL2RA IL6
20 positive regulation of interferon-gamma production GO:0032729 9.88 IL1B TLR4 TNF
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 IL1B TLR4 TNF
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 HMGB1 IL1B TLR4 TNF
23 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 IL1A IL1B TNF
24 protein kinase B signaling GO:0043491 9.87 CCL5 IL1B TGFB1 TNF
25 negative regulation of mitotic cell cycle GO:0045930 9.86 IL10 TGFB1 TNF
26 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.86 CASP3 IL1A IL1B
27 negative regulation of T cell proliferation GO:0042130 9.86 HLA-DRB1 IL10 IL2RA TGFB1
28 T cell homeostasis GO:0043029 9.85 CASP3 IL2RA TGFB1
29 positive regulation of cytokine secretion GO:0050715 9.85 IL10 IL1A TNF
30 response to glucocorticoid GO:0051384 9.85 CASP3 HMGB1 IL10 IL1RN IL6 TNF
31 positive regulation of interleukin-8 production GO:0032757 9.84 IL1B TLR4 TNF
32 positive regulation of vascular endothelial growth factor production GO:0010575 9.84 IL1A IL1B TGFB1
33 negative regulation of interferon-gamma production GO:0032689 9.84 HLA-DRB1 HMGB1 IL10 TLR4
34 negative regulation of interleukin-6 production GO:0032715 9.83 IL10 TLR4 TNF
35 positive regulation of interleukin-12 production GO:0032735 9.83 CD40LG HMGB1 TLR4
36 positive regulation of interleukin-10 production GO:0032733 9.82 CD40LG HMGB1 TLR4
37 positive regulation of chemokine production GO:0032722 9.81 IL6 TLR4 TNF
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 CCL5 IL1B TGFB1 TLR4 TNF
39 positive regulation of interleukin-6 production GO:0032755 9.8 HMGB1 IL1A IL1B IL6 TLR4 TNF
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
41 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.77 HMGB1 IL1A IL1B
42 inflammatory response to antigenic stimulus GO:0002437 9.76 HLA-DRB1 HMGB1 IL1B IL2RA
43 positive regulation of interferon-alpha production GO:0032727 9.75 HMGB1 TLR4
44 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.75 IL1A IL1B
45 negative regulation of interleukin-17 production GO:0032700 9.75 TGFB1 TLR4
46 T-helper 1 type immune response GO:0042088 9.75 HLA-DRB1 TLR4
47 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.74 IL10 IL1RN
48 negative regulation of lipid storage GO:0010888 9.74 IL6 TNF
49 positive regulation of chemokine biosynthetic process GO:0045080 9.74 IL1B TNF
50 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TLR4 TNF

Molecular functions related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.62 IL10 IL6 TGFB1 THPO
2 tumor necrosis factor receptor binding GO:0005164 9.43 CD40LG FASLG TNF
3 cytokine activity GO:0005125 9.4 CCL5 CD40LG FASLG HMGB1 IL10 IL1A
4 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
5 protein binding GO:0005515 10.11 CASP3 CCL5 CD40LG CSF3R FASLG FCER2

Sources for Idiopathic Neutropenia

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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