Idiopathic Scoliosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IDP070 MIFTS: 42	Idiopathic Scoliosis Categories: Bone diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis ¹¹ ⁵ ¹⁴

Scoliosis Idiopathic ⁵³

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060250

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Summaries for Idiopathic Scoliosis

Disease Ontology: ¹¹ A scoliosis with no known cause.

MalaCards based summary: Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to marfan syndrome and orthostatic intolerance. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Burn wound healing. The drugs Cyclobenzaprine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and spinal cord, and related phenotypes are Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation and muscle

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Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)

#	Related Disease	Score	Top Affiliating Genes
1	marfan syndrome	30.2	FBN1 ELN COL1A2 CD36
2	orthostatic intolerance	30.1	NOS2 FBN1 ELN COL1A2
3	atrial heart septal defect	30.1	FBN1 ELN CHD7
4	ehlers-danlos syndrome	29.9	FBN1 ELN COL1A2 CD36
5	loeys-dietz syndrome	29.8	FBN1 ELN COL1A2
6	scoliosis	29.8	SNTG1 POC5 NOS1 MTNR1B LOC108228202 LBX1
7	distal arthrogryposis	29.7	FBN1 ELN COL1A2 ADGRG6
8	cerebral palsy	29.7	NOS2 NOS1 COL1A2 CD36
9	brittle bone disorder	29.6	FBN1 ELN COL1A2 CD36
10	vascular disease	29.0	NOS2 KRIT1 FBN1 ELN
11	scoliosis, isolated 1	12.0
12	scoliosis, isolated 3	11.4
13	gaze palsy, familial horizontal, with progressive scoliosis 1	11.1
14	scoliosis, isolated 2	11.0
15	scoliosis, isolated 4	11.0
16	scoliosis, isolated 5	11.0
17	back pain	10.8
18	syringomyelia	10.6
19	overgrowth syndrome	10.6
20	idiopathic syringomyelia	10.6
21	non-alcoholic steatohepatitis	10.5
22	intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	10.5
23	pain agnosia	10.5
24	chiari malformation	10.5
25	charge syndrome	10.5
26	body mass index quantitative trait locus 1	10.5
27	scheuermann disease	10.5
28	bone mineral density quantitative trait locus 3	10.5
29	leptin deficiency or dysfunction	10.5
30	intervertebral disc disease	10.4
31	spondylolisthesis	10.4
32	rickets	10.4
33	degenerative disc disease	10.4
34	47 xxx syndrome	10.4
35	contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	10.4
36	ataxia with vitamin e deficiency	10.4
37	spinal disease	10.4
38	tethered spinal cord syndrome	10.4
39	infantile scoliosis	10.4
40	twin anemia-polycythemia sequence	10.4
41	polykaryocytosis inducer	10.4
42	pneumothorax, primary spontaneous	10.3
43	tatton-brown-rahman syndrome	10.3
44	respiratory failure	10.3
45	pneumothorax	10.3
46	hand skill, relative	10.3
47	virus-associated trichodysplasia spinulosa	10.3
48	anterior cutaneous nerve entrapment syndrome	10.3
49	cartilage disease	10.3
50	radiculopathy	10.3

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:

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Symptoms & Phenotypes for Idiopathic Scoliosis

GenomeRNAi Phenotypes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation	GR00206-A	8.8	KRIT1 NOS1 NOS2

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	9.85	ADGRG6 CD36 CHD7 COL1A2 ELN FBN1
2	cardiovascular system	MP:0005385	9.65	ADGRG6 CD36 CHD7 COL1A2 ELN FBN1
3	skeleton	MP:0005390	9.32	ADGRG6 BNC2 CD36 CHD7 COL1A2 ELN

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Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cyclobenzaprine

Approved

Phase 4

303-53-7

2895

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1, 1867-66-9

3821

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Thrombin

Approved, Investigational

Phase 4

Cefazolin

Approved

Phase 4

25953-19-9

33255

Acetylcholine

Approved, Investigational

Phase 4

51-84-3

187

Caffeine

Approved

Phase 4

58-08-2

2519

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

3003 5743

Hydromorphone

Approved, Illicit

Phase 4

466-99-9, 71-68-1

5284570

Acetaminophen, hydrocodone drug combination

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Anesthetics, Intravenous

Phase 4

Anesthetics, General

Phase 4

Anesthetics, Dissociative

Phase 4

Pharmaceutical Solutions

Phase 4

Hemostatics

Phase 4

Coagulants

Phase 4

Bone wax

Phase 4

Hypnotics and Sedatives

Phase 4

Dialysis Solutions

Phase 4

Analgesics

Phase 4

Neurotransmitter Agents

Phase 4

abobotulinumtoxinA

Phase 4

Botulinum Toxins, Type A

Phase 4

Botulinum Toxins

Phase 4

Cholinergic Agents

Phase 4

Central Nervous System Stimulants

Phase 4

Phosphodiesterase Inhibitors

Phase 4

Anesthetics, Local

Phase 4

Anti-Arrhythmia Agents

Phase 4

Sodium Channel Blockers

Phase 4

Diuretics, Potassium Sparing

Phase 4

Analgesics, Opioid

Phase 4

Anesthetics

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

Antiemetics

Phase 4

glucocorticoids

Phase 4

Anti-Inflammatory Agents

Phase 4

Gastrointestinal Agents

Phase 4

Narcotics

Phase 4

Calcium carbonate

Approved, Investigational

Phase 3

471-34-1

Anti-Ulcer Agents

Phase 3

Antacids

Phase 3

Bupivacaine

Approved, Investigational

Phase 2

2180-92-9, 38396-39-3

2474

Acetaminophen

Approved

Phase 2

103-90-2

1983

Interventional clinical trials:

(show top 50) (show all 250)

#	Name	Status	NCT ID	Phase	Drugs
1	A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis	Unknown status	NCT02651324	Phase 4	Ketamine
2	Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis	Completed	NCT00510575	Phase 4
3	Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis	Completed	NCT02669004	Phase 4	Intermittent bolus epidural morphine;continuous epidural morphine
4	Effectiveness Of Gelatin Matrix With Human Derived Thrombin On Blood Loss, Surgical Time, Hospital Stay And Complications In Adolescents Undergoing Spine Surgery For Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial.	Completed	NCT01451788	Phase 4
5	Comparison of Measured Versus Predicted Blood Propofol Concentrations During Total Intravenous Anaesthesia in Children Undergoing Spinal Surgery	Completed	NCT01932424	Phase 4	Propofol 2% (Diprivan 2%, Astra Zeneca UK)
6	Skeletal Muscle and Adipose Tissue Concentrations of Cefazolin Comparing Two Different Dosing Regimens During Pediatric Posterior Spinal Fusion Surgery	Completed	NCT03190668	Phase 4	Bolus dose of Cefazolin;Continuous Cefazolin drip
7	Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents	Completed	NCT01325493	Phase 4	Ketamine;Normal Saline
8	Intravenous Lignocaine as an Analgesic Adjunct in Adolescent Idiopathic Scoliosis Surgery (IGNITE-AIS Study)	Recruiting	NCT04931433	Phase 4	Lignocaine;Normal saline
9	Dysport ® (abobotulinumtoxinA) as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis	Recruiting	NCT03935295	Phase 4	AbobotulinumtoxinA;Placebos
10	Oral Caffeine Decreases the Frequency of Opioid Demand in AIS Patients After Spinal Fusion	Recruiting	NCT04950660	Phase 4	Caffeine Tablet;Placebo
11	Intravenous Lidocaine to Reduce Postoperative Opioid Consumption and Improve Recovery After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis	Enrolling by invitation	NCT03893318	Phase 4	IV lidocaine;Placebos
12	The Impact of Perioperative Steroid Dosing on the Acute Phase Response in Adolescent Idiopathic Scoliosis	Not yet recruiting	NCT05561725	Phase 4	Dexamethasone postoperative;Standard of Care
13	Identification of the Optimal Analgesic Dose of Intrathecal Hydromorphone for Pediatric Patients Undergoing Posterior Spine Surgery for Idiopathic Scoliosis	Not yet recruiting	NCT05552443	Phase 4	Hydromorphone 2.5 mcg/kg;Hydromorphone 2.75 mcg/kg;Hydromorphone 3 mcg/kg;Hydromorphone 3.25 mcg/kg;Hydromorphone 3.5 mcg/kg;Hydromorphone 4 mcg/kg;Hydromorphone 4.5 mcg/kg;Hydromorphone 5 mcg/kg
14	A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis.	Withdrawn	NCT00768313	Phase 4
15	Can Calcium and Vitamin D Supplementation Improve Bone Mineral Density and Curve Progression in Girls With Adolescent Idiopathic Scoliosis?	Completed	NCT01103115	Phase 3
16	Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial	Completed	NCT01108211	Phase 3
17	Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children	Recruiting	NCT04069169	Phase 3	Lidocaine;Saline Solution
18	The Use of Perioperative Gabapentin in Adolescents Undergoing Posterior Spinal Fusion for Idiopathic Scoliosis to Prevent Chronic Postsurgical Pain, a Pilot Study.	Withdrawn	NCT03867240	Phase 3	Gabapentin
19	Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis	Completed	NCT02571491	Phase 2	Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
20	Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis	Completed	NCT00273598	Phase 2
21	The Efficacy of Intravenous Tranexamic Acid in Decreasing Blood Loss in Pediatric Idiopathic Scoliosis Surgery?	Completed	NCT01813058	Phase 1, Phase 2	Tranexamic Acid;Placebo
22	Analgesia Following Posterior Spinal Fusion: Methadone vs Magnesium	Completed	NCT01795495	Phase 2	Methadone hydrochloride;Magnesium Sulfate;Remifentanil
23	Ultrasound Guided Erector Spinae Plane Block in Scoliotic Adolescents Undergoing Posterior Spine Instrumentation . A Randomized Controlled Trial	Completed	NCT03968146	Phase 2	Fentanyl;additional Fentanyl;Morphine;rescue Morphine;pethidine;Ketorolac;Acetaminophen
24	Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis	Recruiting	NCT04922983	Phase 2	Botulinum toxin type A
25	Blood Loss and Transfusion Requirement in Pediatric Patients With Non-Idiopathic Scoliosis Treated With Tranexamic Acid Undergoing Posterior Spinal Instrumentation and Fusion.	Terminated	NCT01089140	Phase 2	Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
26	Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics During Static and Dynamic Activities in Functional and Idiopathic Scoliosis Patients	Completed	NCT00155545	Phase 1
27	An Innovative Body-Mapping Tank Top Equipped With Biofeedback System for Adolescents With Early Scoliosis	Completed	NCT02471508	Phase 1
28	A Protocol of Accelerated Rehabilitation for Patients Undergoing Adolescent Idiopathic Scoliosis Correction Surgery - An Internal Pilot Study	Unknown status	NCT03719807
29	Investigation of The Effects of Scoliosis Specific Exercises Before Adolescent Idiopathic Scoliosis Surgery	Unknown status	NCT04357561
30	Ultrasound Guided Bilateral Retrolaminar Block as Analgesia for Adolescent Idiopathic Scoliosis Correction	Unknown status	NCT04336111
31	Ultrasound Guided Bilateral Erector Spinae Block as Analgesia for Adolescent Idiopathic Scoliosis Correction	Unknown status	NCT04336046		normal saline;Bupivacaine
32	Effect of the Severity and the Treatment (Orthosis Versus Surgery)of the Idiopathic Scoliosis on the Locomotor Mechanism of the Gait.	Unknown status	NCT00842218
33	Application Research of Physiotherapeutic Scoliosis Specific Exercises in Adolescent Idiopathic Scoliosis	Unknown status	NCT02968043
34	Treatment of Adolescent Idiopathic Scoliosis Patients Using the Ellipse MAGEC System	Unknown status	NCT01633931
35	Efficacy of Three-dimensionally Integrated Exercise for Scoliosis in Patients With Adolescent Idiopathic Scoliosis	Unknown status	NCT03427970
36	Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis	Unknown status	NCT02819245
37	Assesment of Enhanced Recovery After Pediatric Idiopathic Scoliosis Surgery	Unknown status	NCT04012528
38	Repeatability and Reproducibility of Low-dose Digital Radiographs in the Idiopathic Scoliosis	Unknown status	NCT03464318
39	Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis	Unknown status	NCT02227537
40	Evaluation of Pain Following Scoliosis Surgery.- RACHIDOL	Unknown status	NCT03686371
41	Efficacy and Safety of Desmopressin Combined With Tranexamic Acid on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery	Unknown status	NCT02084342		tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
42	Retrospective Review With Prospective Surveillance of Safety and Efficacy in a Clinical Series of Spinal Tethering Patients	Unknown status	NCT02897453
43	Effect of Ultra-short-term Treatment of Patients With Iron Deficiency or Anemia Undergoing Adolescent Scoliosis Correction	Unknown status	NCT04343170		Placebo;ferric carboxymaltose , α erythropoietin, vitamin B12, oral folic acid
44	Comparison of Preoperative 3D Spine Reconstruction With the EOS System and Peroperative 3D Spine Reconstruction With SURGIVISIO	Unknown status	NCT04611490
45	Prevalence of Myofascial Pain Syndrome in Adolescent Idiopathic Scoliosis and the Relationship Between Myofascial Pain Syndrome and Spinal Coronal and Sagittal Alignment in Adolescent Idiopathic Scoliosis	Completed	NCT05185050
46	Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients	Completed	NCT03820895
47	Leg Length Discrepancy and Adolescent Idiopathic Scoliosis: Clinical and Radiological Characteristics	Completed	NCT04713397
48	The Effect of Schroth Method on Pain, Body Awareness and Quality of Life in Adolescent Individuals With Idiopathic Scoliosis	Completed	NCT04689295
49	Evaluation of Virtual Reality Intervention After Pediatric Idiopathic Scoliosis Surgery to Reduce Postoperative Pain and Opioid Consumption	Completed	NCT04584970
50	Ultrasonographic Evaluation of Abdominal Muscle Thickness Symmetry and Correlation With Pulmonary Function Test in Adolescent Idiopathic Scoliosis	Completed	NCT04567914

Search NIH Clinical Center for Idiopathic Scoliosis

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Genetic Tests for Idiopathic Scoliosis

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Anatomical Context for Idiopathic Scoliosis

Organs/tissues related to Idiopathic Scoliosis:

MalaCards : Bone, Skeletal Muscle, Spinal Cord, Lung, Bone Marrow, Brain, Pineal

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Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 8268)

#	Title	Authors	PMID	Year
1	Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. ⁵³ ⁶²	Qiu XS...Cheng JC	17632395	2007
2	[Expression of calmodulin and nNOS in the paraspinal muscles in idiopathic scoliosis]. ⁵³ ⁶²	Zhao Y...Qiu GX	15387945	2004
3	[Expression of neuronal nitric oxide synthase and inducible nitric oxide synthase in the erector spinal muscles in idiopathic scoliosis]. ⁵³ ⁶²	Zhao Y...Qiu GX	15379275	2004
4	Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis. ⁵³ ⁶²	Miller NH...Blanton SH	8982144	1996
5	Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: A large-scale assessment by ultra-high-resolution micro-computed tomography. ⁶²	Yang KG...Lee WY	36341948	2023
6	Cervical sagittal alignment is influenced by changes in thoracic and lumbar sagittal alignments after correction surgery in patients with lenke type 6 adolescent idiopathic scoliosis. ⁶²	Okubo T...Watanabe K	36147585	2022
7	Current models to understand the onset and progression of scoliotic deformities in adolescent idiopathic scoliosis: a systematic review. ⁶²	Meiring AR...Smit TH	36454530	2022
8	Risk factors for vertebral bridging in residual adolescent idiopathic scoliosis with thoracolumbar/lumbar curves. ⁶²	Sakashita K...Yamazaki M	36462997	2022
9	Ultrasound to X-ray synthesis generative attentional network (UXGAN) for adolescent idiopathic scoliosis. ⁶²	Jiang W...Bai C	35926252	2022
10	Providence nighttime brace is as effective as fulltime Boston brace for female patients with adolescent idiopathic scoliosis: A retrospective analysis of a randomized cohort. ⁶²	Capek V...Wessberg P	36458131	2022
11	Bone mineral density in children and young adults with idiopathic scoliosis: a systematic review and meta-analysis. ⁶²	Yang Y...Du Q	36450863	2022
12	Melatonin and adolescent idiopathic scoliosis: The present evidence. ⁶²	Gargano G...Maffulli N	34489192	2022
13	The risk of delayed spinal cord injury in pediatric spinal deformity surgery. ⁶²	Rutges JPHJ...Schlosser TPC	36459389	2022
14	Response to the letter to the editor regarding, "Pulmonary function in children and adolescents with untreated idiopathic scoliosis: a systematic review with meta-regression analysis". ⁶²	Kempen DHR...Willigenburg NW	36089264	2022
15	Letter to the editor regarding "Pulmonary function in children and adolescents with untreated idiopathic scoliosis: a systematic review with meta-regression analysis". ⁶²	Pontes-Silva A	36464413	2022
16	"Letter to the Editor: Treatment of infantile idiopathic scoliosis using a novel thoracolumbosacral orthosis: a case report". ⁶²	Fludder CJ...Keil BG	36471436	2022
17	Risk factors and clinical impact of persistent coronal imbalance after posterior spinal fusion in thoracolumbar/lumbar idiopathic scoliosis. ⁶²	Banno T...Matsuyama Y	35901689	2022
18	End of growth results of an optimised treatment for 40-degree idiopathic scoliosis at age 1: A case report. ⁶²	Negrini S...Zaina F	35489686	2022
19	Early dynamic changes within the spine following posterior fusion using hybrid instrumentation in adolescents with idiopathic scoliosis: a gait analysis study. ⁶²	Pesenti S...Jouve JL	34008049	2022
20	Outcomes of Posterior Spinal Fusion in Pediatric Patients with Down Syndrome. ⁶²	Fraser HG...Fletcher ND	36166508	2022
21	Three-dimensional correction of scoliosis by a double spring reduction system as a dynamic internal brace: a pre-clinical study in Göttingen minipigs. ⁶²	Lemans JVC...Kruyt MC	36343914	2022
22	Reliability and Validity of the Adapted Chinese Version of the Quality of Life Profile for Spine Deformities in Adolescents With Idiopathic Scoliosis. ⁶²	Hu M...Zhao J	36355378	2022
23	The role of pineal gland volume in the development of scoliosis. ⁶²	Batin S...Unur E	36374335	2022
24	3D Surface Topographic Optical Scans Yield Highly Reliable Global Spine Range of Motion Measurements in Scoliotic and Non-Scoliotic Adolescents. ⁶²	Page K...Widmann RF	36421205	2022
25	CT analysis of the posterior anatomical landmarks of the scoliotic spine. ⁶²	Tromp IN...Castelein RM	36064659	2022
26	The Volume-Cost Relationship: How Does Surgical Volume Affect Cost and Value in AIS Surgery. ⁶²	Sarwahi V...Hasan S	35509023	2022
27	Reliability and validity of an adapted Saudi Arabic version of scoliosis research society outcomes questionnaire (SRS-30) in Saudi Arabia. ⁶²	Alzakri A	36436116	2022
28	Outcome of bracing vs. surgical treatment in adolescents with idiopathic scoliosis based on device measured daily physical activity: a prospective pilot study. ⁶²	Chopra S...Kaufman KR	36445379	2022
29	Indications and timing of revision spine surgery in adults after adolescent surgery for idiopathic scoliosis. ⁶²	Diederich A...Burton D	35695990	2022
30	Socioeconomic and geographic disparities in pediatric scoliosis surgery. ⁶²	Booze ZL...Roberto R	35841474	2022
31	Innovative technique for early-onset scoliosis casting using Jackson table. ⁶²	Montgomery BK...Vorhies J	35776363	2022
32	Bracing for juvenile idiopathic scoliosis: retrospective review from bracing to skeletal maturity. ⁶²	Whitaker AT...Glotzbecker MP	35852786	2022
33	Morphological differences in scoliosis curvatures as a cause of difficulties in its early detection based on angle of trunk inclination. ⁶²	Kluszczynski M...Wasik J	36324093	2022
34	Intraoperative neuromonitoring in non-idiopathic pediatric scoliosis operated with minimally fusionless procedure: A series of 290 patients. ⁶²	Besse M...Ferrero E	36167615	2022
35	Conditional inactivation of the L-type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice. ⁶²	Iwahashi S...Hinoi E	36161979	2022
36	Cross-cultural French-Canadian adaptation and psychometric assessment of the Italian Spine Youth Quality of Life (ISYQOL) questionnaire. ⁶²	Forest C...Fortin C	35870800	2022
37	Complication risks and costs associated with Ponte osteotomies in surgical treatment of adolescent idiopathic scoliosis: insights from a national database. ⁶²	Shaheen M...Vorhies JS	35810408	2022
38	Sport improved medium-term results in a prospective cohort of 785 adolescents with idiopathic scoliosis braced full time. SOSORT 2018 award winner. ⁶²	Negrini A...Negrini S	36083351	2022
39	A case of chyluria with nephrotic-range proteinuria caused by lymphatic malformation, leading to a diagnosis of Klippel-Trenaunay syndrome. ⁶²	Izumi Y...Mukoyama M	36369386	2022
40	The Extension of Surgery Predicts Acute Postoperative Pain, While Persistent Postoperative Pain Is Related to the Spinal Pathology in Adolescents Undergoing Posterior Spinal Fusion. ⁶²	Yrjala T...Helenius L	36360457	2022
41	Clinical Application of the Roussouly Classification in the Sagittal Balance Reconstruction of 101 Adolescent Idiopathic Scoliosis Patients. ⁶²	Li J...Yu M	36398431	2022
42	Is the Integration Problem in the Sensoriomotor System the Cause of Adolescent Idiopathic Scoliosis? ⁶²	Payas A...Unur E	36418290	2022
43	Restoration of thoracic kyphosis in adolescent idiopathic scoliosis with patient-specific rods: did the preoperative plan match postoperative sagittal alignment? ⁶²	Thomas ES...Aminian A	36357540	2022
44	Does the use of intrawound povidone-iodine irrigation and local vancomycin powder impact surgical site infection rate in adolescent idiopathic scoliosis surgery? ⁶²	Mallet C...Ilharreborde B	35913622	2022
45	The preliminary outcomes of vertebral body tethering in treating adolescent idiopathic scoliosis: a systematic review. ⁶²	Zhang H...Pi G	35841473	2022
46	Pulmonary function after thoracoplasty for adolescent idiopathic scoliosis: a systematic review and meta-analysis. ⁶²	Kumar V...Bansal P	36069937	2022
47	Long-term outcome of patients with adolescent idiopathic scoliosis seeking nonoperative treatment after a mean follow-up of 42 years. ⁶²	Farshad M...Kabelitz M	35819723	2022
48	The Effects of Body Mass Index and Spine Flexibility on Surgical Outcomes for Patients With Adolescent Idiopathic Scoliosis. ⁶²	Linden GS...Hogue GD	35913803	2022
49	Return to sport after posterior spinal fusion for adolescent idiopathic scoliosis: what variables actually have an influence? A retrospective study. ⁶²	Ruffilli A...Faldini C	35723854	2022
50	Accuracy of thoracic pedicle screw placement in adolescent idiopathic scoliosis patients using the entry point identified by new landmarks: a computed tomography study. ⁶²	Jiang J...Yu Y	36333715	2022

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Genes for Idiopathic Scoliosis

Genes related to Idiopathic Scoliosis (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CHL1-AS2	CHL1 Antisense RNA 2	RNA Gene	150	Experimental evidence: Mutation ³⁷	21216876
2	DSCAM-AS1	DSCAM Antisense RNA 1	RNA Gene	150	Experimental evidence: Mutation ³⁷	21216876
3	BNC2	Basonuclin 2	Protein Coding	23.56	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
4	SNTG1	Syntrophin Gamma 1	Protein Coding	22.93	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
5	MTNR1B	Melatonin Receptor 1B	Protein Coding	22.42	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17632395
6	CHD7	Chromodomain Helicase DNA Binding Protein 7	Protein Coding	22.18	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
7	FBN1	Fibrillin 1	Protein Coding	17.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18810045 8982144
8	IS1	Adolescent Idiopathic Scoliosis	Genetic Locus	17.09	GeneCards inferred via : Publications Gene name (show sections)
9	LOC108228202	PEC7 Enhancer Downstream Of PAX1	Functional Element	16.58	GeneCards inferred via : Publications Summaries (show sections)
10	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	16.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18810052 8982144
11	ELN	Elastin	Protein Coding	10.46	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	NOS1	Nitric Oxide Synthase 1	Protein Coding	9.25	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15379275 15387945
13	LBX1	Ladybird Homeobox 1	Protein Coding	8	DISEASES inferred ¹⁴
14	MIR1306	MicroRNA 1306	RNA Gene	7.32	DISEASES inferred ¹⁴ ¹⁴
15	POC5	POC5 Centriolar Protein	Protein Coding	7.3	DISEASES inferred ¹⁴
16	CD36	CD36 Molecule	Protein Coding	7.21	GeneCards inferred via : Publications (show sections)
17	ADGRG6	Adhesion G Protein-Coupled Receptor G6	Protein Coding	6.94	DISEASES inferred ¹⁴
18	KRIT1	KRIT1 Ankyrin Repeat Containing	Protein Coding	6.87	GeneCards inferred via : Publications (show sections)
19	NOS2	Nitric Oxide Synthase 2	Protein Coding	6.87	GeneCards inferred via : Publications (show sections)

Sources

Variations for Idiopathic Scoliosis

ClinVar genetic disease variations for Idiopathic Scoliosis:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	CELSR2	NM_001408.3(CELSR2):c.6859G>A (p.Val2287Ile)	SNV	Uncertain Significance	397652	rs141489111	GRCh37: 1:109812092-109812092 GRCh38: 1:109269470-109269470

Sources

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Sources

Pathways for Idiopathic Scoliosis

Pathways related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.37	NOS2 COL1A2 CD36
2	Burn wound healing ⁷⁴	10.67	FBN1 ELN COL1A2
3	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics ⁶⁰	10.64	NOS2 NOS1
4	NO-dependent CFTR activation (normal and CF) ²²	10.07	NOS2 NOS1

Sources

GO Terms for Idiopathic Scoliosis

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	camera-type eye development	GO:0043010	9.77	MTNR1B FBN1 CHD7
2	positive regulation of guanylate cyclase activity	GO:0031284	9.71	NOS2 NOS1
3	cell redox homeostasis	GO:0045454	9.63	NOS2 NOS1 KRIT1
4	extracellular matrix assembly	GO:0085029	9.61	ELN COL1A2
5	arginine catabolic process	GO:0006527	9.56	NOS2 NOS1
6	cellular biosynthetic process	GO:0044249	9.32	NOS2 NOS1
7	peptidyl-cysteine S-nitrosylation	GO:0018119	9.26	NOS2 NOS1
8	nitric oxide mediated signal transduction	GO:0007263	9.1	NOS2 NOS1 CD36

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix constituent conferring elasticity	GO:0030023	9.56	FBN1 ELN
2	arginine binding	GO:0034618	9.46	NOS2 NOS1
3	tetrahydrobiopterin binding	GO:0034617	9.26	NOS2 NOS1
4	nitric-oxide synthase activity	GO:0004517	8.92	NOS2 NOS1