MCID: IDP070
MIFTS: 39

Idiopathic Scoliosis

Categories: Bone diseases

Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 6 15
Scoliosis Idiopathic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to pectus excavatum and scoliosis. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2), and among its related pathways/superpathways is Degradation of the extracellular matrix. The drugs Thrombin and Morphine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung.

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 pectus excavatum 29.8 ACAN ADGRG6 FBN1
2 scoliosis 29.6 ACAN ADGRG6 BNC2 CALM1 CELSR2 CHD7
3 scoliosis, isolated 1 12.3
4 scoliosis, isolated 3 11.7
5 horizontal gaze palsy with progressive scoliosis 11.1
6 scoliosis, isolated 2 11.0
7 scoliosis, isolated 4 11.0
8 scoliosis, isolated 5 11.0
9 syringomyelia 10.2
10 spondylolisthesis 10.2
11 body mass index quantitative trait locus 1 10.2
12 rare isolated myopia 10.1 CHD7 FBN1
13 pseudoarthrosis 10.1
14 chiari malformation 10.1
15 stiff skin syndrome 10.0 COL1A2 FBN1
16 ganglioneuroma 10.0
17 hypermobile ehlers-danlos syndrome 10.0
18 scleroderma, familial progressive 10.0 COL1A2 FBN1
19 achondrogenesis, type ii 9.9 ACAN MATN1
20 marfan syndrome 9.9
21 bone mineral density quantitative trait locus 3 9.9
22 alkuraya-kucinskas syndrome 9.9
23 osteoblastoma 9.9
24 spondylolysis 9.9
25 myopathy 9.9
26 degos 'en cocarde' erythrokeratoderma 9.9
27 exotropia 9.9 ACAN FBN1
28 bone structure disease 9.9 ACAN ADGRG6 LBX1
29 spinal stenosis 9.8 ACAN COL1A2
30 adamantinoma of long bones 9.8
31 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 9.8
32 hemifacial hyperplasia 9.8
33 motion sickness 9.8
34 neurofibromatosis, type i 9.8
35 neurofibromatosis, type iv, of riccardi 9.8
36 osteoporosis 9.8
37 polykaryocytosis inducer 9.8
38 scheuermann disease 9.8
39 neural tube defects 9.8
40 thrombophilia due to thrombin defect 9.8
41 varicose veins 9.8
42 diastematomyelia 9.8
43 mitochondrial myopathy 9.8
44 insulin-like growth factor i 9.8
45 intervertebral disc disease 9.8
46 orthostatic intolerance 9.8
47 anorexia nervosa 9.8
48 anxiety 9.8
49 degenerative disc disease 9.8
50 muscle disorders 9.8

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:



Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
3
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
4
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
5
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
6
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
7
Cefazolin Approved Phase 4 25953-19-9 656510 33255
8
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
9
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
10
Cyclobenzaprine Approved Phase 4 303-53-7 2895
11
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
12
Acetaminophen Approved Phase 4 103-90-2 1983
13 Coagulants Phase 4,Phase 1,Phase 2,Not Applicable
14 Hemostatics Phase 4,Phase 1,Phase 2,Not Applicable
15 Analgesics Phase 4,Phase 3,Phase 2
16 Analgesics, Opioid Phase 4,Phase 2
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
18 Narcotics Phase 4,Phase 2
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
20 Anesthetics, General Phase 4,Phase 1,Phase 2,Not Applicable
21 Anesthetics, Dissociative Phase 4,Phase 2
22 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
23 Anesthetics, Intravenous Phase 4,Phase 2,Not Applicable
24 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
25 Anesthetics Phase 4,Phase 1,Phase 2,Not Applicable
26 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
27 Anesthetics, Local Phase 4
28 Hypnotics and Sedatives Phase 4,Phase 2,Not Applicable
29 Psychotropic Drugs Phase 4,Phase 3
30 calcium channel blockers Phase 4,Phase 3,Phase 2
31 Anti-Anxiety Agents Phase 4,Phase 3
32 Tranquilizing Agents Phase 4,Phase 3
33 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
34 Anticonvulsants Phase 4,Phase 3,Phase 2
35 Anti-Infective Agents Phase 4
36 Pharmaceutical Solutions Phase 4,Phase 3
37 Dialysis Solutions Phase 4
38 Anti-Bacterial Agents Phase 4
39 Acetaminophen, hydrocodone drug combination Phase 4
40
Calcium Carbonate Approved, Investigational Phase 3 471-34-1
41
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
42
gamma-Aminobutyric acid Approved, Investigational Phase 3 56-12-2 119
43
Clevidipine Approved, Investigational Phase 2, Phase 3 167221-71-8
44
Vitamin D3 Approved, Nutraceutical Phase 3,Not Applicable 67-97-0 5280795 6221
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 1406-16-2
46
Ergocalciferol Approved, Nutraceutical Phase 3,Not Applicable 50-14-6 5280793
47 Micronutrients Phase 3,Not Applicable
48 Gastrointestinal Agents Phase 3
49 Anti-Ulcer Agents Phase 3
50 Antacids Phase 3

Interventional clinical trials:

(show top 50) (show all 133)
# Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
3 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
4 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
5 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
6 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
7 Skeletal Muscle and Adipose Tissue Study Recruiting NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
8 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
9 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Active, not recruiting NCT02651324 Phase 4 Ketamine
10 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
11 Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01103115 Phase 3
12 Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01108211 Phase 3
13 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
14 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
15 The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
16 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Active, not recruiting NCT02285621 Phase 3
17 Multicenter Schroth Exercise Trial for Scoliosis Unknown status NCT01610908 Phase 2
18 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
19 Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
20 Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis Completed NCT00273598 Phase 2
21 Methadone vs Magnesium in Spinal Fusion Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
22 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
23 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
24 Safety and Efficacy of Body-mapping Tank Top Equipped With Biofeedback System for Adolescent With Early Scoliosis Completed NCT02471508 Phase 1
25 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
26 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245 Not Applicable
27 Scoliosis-Specific Exercises for At-Risk AIS Curves Unknown status NCT02807545 Not Applicable
28 The Idiopathic Scoliosis and Its Treatment (Orthopaedic and Surgery): Effect of the Severity, the Orthosis and the Arthrodesis on the Gait Unknown status NCT00842218
29 Study of DDAVP Combined With TXA on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 Not Applicable tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
30 Scoliosis and Quality of Life of Adolescents Unknown status NCT02890654
31 Multi-Center Project: Spinal Abnormalities in Neurofibromatosis Type1 (NF1) Patients Unknown status NCT00667836
32 Three-dimensional Effects of Bracing in Adolescent Idiopathic Scoliosis Completed NCT03298256
33 The Effect of the Inspiratory Muscle Training on Respiratory Parameters and Functional Capacity in Idiopathic Scoliosis Completed NCT03391895 Not Applicable
34 Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Completed NCT03539770
35 Prediction of 3D Effect of Brace in Idiopathic Scoliosis Treatment Using EOS Imaging System and "Anatomic Transfer". Completed NCT03209752
36 The Comparison of Core Stabilization Exercise With Scientific Exercise Approach to Scoliosis in Idiopathic Scoliosis Completed NCT02978820 Not Applicable
37 Effect of Compliance Counseling on Brace Success in Patients With Idiopathic Scoliosis Completed NCT02412137 Early Phase 1
38 Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA) Completed NCT02302534 Not Applicable
39 Gait and Postural Stability Assessment in Children With Idiopathic Scoliosis Undergoing Posterior Spine Instrumentation Completed NCT01109082
40 An Aerobic Exercising Program on Respiratory Muscle Strength in Patients With Adolescent Idiopathic Scoliosis Completed NCT00886652 Not Applicable
41 Spinal Stabilization Exercises for Low Back Pain in Adolescents With Idiopathic Scoliosis Completed NCT01550497 Not Applicable
42 Ghrelin Resistance in Adolescents With Idiopathic Scoliosis Completed NCT02829476 Not Applicable
43 Effectiveness of Exercises in Adolescent Idiopathic Scoliosis Completed NCT02552615 Not Applicable
44 Evaluate Initial Safety of the HemiBridge™ System in Guided Spinal Growth Treatment of Progressive Idiopathic Scoliosis Completed NCT01465295 Not Applicable
45 Impact of the Choice of the Distal Vertebral in the Surgery of the Thoracic Adolescent Idiopathic Scoliosis Completed NCT02791776 Not Applicable
46 Scoliosis Surgery Using the PASS® LP System Completed NCT01019109
47 Anesthetic Optimization in Scoliosis Surgery Completed NCT02481570 Not Applicable
48 Short-term Effects of the Simultaneous Use of Two Physiotherapeutic Methods in the Treatment of Adolescent Idiopathic Scoliosis - Pilot Study Completed NCT01250860 Not Applicable
49 Feasibility Evaluation Study of the MID-C Device Completed NCT03071471
50 Feasibility Study of MID-C for AIS Completed NCT03071445

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

MalaCards organs/tissues related to Idiopathic Scoliosis:

41
Bone, Testes, Lung, Skeletal Muscle, Spinal Cord, Brain, Skin

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 1416)
# Title Authors Year
1
Cardiac Risk Factors and Complications After Spinal Fusion for Idiopathic Scoliosis in Children. ( 30527472 )
2019
2
Standardized traction versus side-bending radiographs in adolescent idiopathic scoliosis: a preliminary study. ( 30252796 )
2019
3
Costs and complications of increased length of stay following adolescent idiopathic scoliosis surgery. ( 30256316 )
2019
4
The effect of Cobb angle correction on spinal length gain in patients with adolescent idiopathic scoliosis. ( 29697489 )
2019
5
Does fusion to T2 compared with T3/T4 lead to improved shoulder balance in adolescent idiopathic scoliosis with a double thoracic curve? ( 29851712 )
2019
6
The effect of upper instrumented vertebra level on cervical sagittal alignment in Lenke 1 adolescent idiopathic scoliosis. ( 29933123 )
2018
7
Vertebral Axial Asymmetry in Adolescent Idiopathic Scoliosis. ( 29413732 )
2018
8
A National Analysis on Predictors of Discharge to Rehabilitation after Corrective Surgery for Adolescent Idiopathic Scoliosis. ( 29933335 )
2018
9
Dynamic ensemble selection of learner-descriptor classifiers to assess curve types in adolescent idiopathic scoliosis. ( 29949021 )
2018
10
Radiographic Methods to Estimate Surgical Outcomes based on Spinal Flexibility Assessment in Patients who have Adolescent Idiopathic Scoliosis: A Systematic Review. ( 29959103 )
2018
11
Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389797 )
2018
12
Accuracy of thoracic pedicle screw placement using freehand technique and triggered EMG in adolescent idiopathic scoliosis: Is it different between concave and convex side? ( 29954289 )
2018
13
Circulating miRNAs as diagnostic biomarkers for adolescent idiopathic scoliosis. ( 29422531 )
2018
14
Association of vitamin D receptor BsmI rs1544410 and ApaI rs7975232 polymorphisms with susceptibility to adolescent idiopathic scoliosis: A systematic review and meta-analysis. ( 29480871 )
2018
15
2016 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. ( 29435499 )
2018
16
Fulcrum flexibility of the main curve predicts postoperative shoulder imbalance in selective thoracic fusion of adolescent idiopathic scoliosis. ( 29931567 )
2018
17
Prevalence and impact of low body mass index on outcomes in patients with adolescent idiopathic scoliosis: a systematic review. ( 29434317 )
2018
18
Rasterstereography versus radiography for assessing shoulder balance in idiopathic scoliosis: A validation study relative to patients' self-image. ( 29945339 )
2018
19
Left Ventricular Mechanics Assessed by 2-dimensional Speckle Tracking Echocardiography in Children and Adolescents with Idiopathic Scoliosis: Errata. ( 29952877 )
2018
20
Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology. ( 29930198 )
2018
21
Dose, image quality and spine modeling assessment of biplanar EOS micro-dose radiographs for the follow-up of in-brace adolescent idiopathic scoliosis patients. ( 29340779 )
2018
22
Surgical treatment for severe and rigid scoliosis: a case-matched study between idiopathic scoliosis and syringomyelia-associated scoliosis. ( 29800706 )
2018
23
Conservative management strategies and stress level in children and adolescents with idiopathic scoliosis. ( 29975372 )
2018
24
Ethnic Variation in Satisfaction and Appearance Concerns in Adolescents With Idiopathic Scoliosis Undergoing Posterior Spinal Fusion With Instrumentation. ( 29413737 )
2018
25
Shoulder Complex Mechanics in Adolescent Idiopathic Scoliosis and Their Relation to Patient-perceived Function. ( 29975295 )
2018
26
Proximal junctional kyphosis following correction surgery in the Lenke 5 adolescent idiopathic scoliosis patient. ( 29960823 )
2018
27
Validation Study of the Thumb Ossification Composite Index (TOCI) in Idiopathic Scoliosis: A Stage-to-Stage Correlation with Classic Tanner-Whitehouse and Sanders Simplified Skeletal Maturity Systems. ( 29975274 )
2018
28
Sagittal plane assessment of spino-pelvic complex in a Central European population with adolescent idiopathic scoliosis: a case control study. ( 29942864 )
2018
29
Who Needs a Pediatric Intensive Care Unit After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis? ( 29413735 )
2018
30
Patterns of coronal curve changes in forward bending posture: a 3D ultrasound study of adolescent idiopathic scoliosis patients. ( 29943198 )
2018
31
Proximal junctional kyphosis in thoracic adolescent idiopathic scoliosis: risk factors and compensatory mechanisms in a multicenter national cohort. ( 29959554 )
2018
32
Criteria for Ending the Distal Fusion at the L3 Vertebra vs. L4 in Surgical Treatment of Adolescent Idiopathic Scoliosis Patients with Lenke Type 3C, 5C, and 6C Curves: Results After Ten Years of Follow-up. ( 29974019 )
2018
33
Supplementary Addendum to "Radiation dose of digital radiography (DR) versus micro-dose x-ray (EOS) on patients with adolescent idiopathic scoliosis: 2016 SOSORT- IRSSD "John Sevastic Award" Winner in Imaging Research". ( 29435497 )
2018
34
Analysis of sensory system aspects of postural stability during quiet standing in adolescent idiopathic scoliosis patients. ( 29929530 )
2018
35
Expert's Comment concerning Grand Rounds case entitled "Chyluria and chylothorax after posterior selective fusion for adolescent idiopathic scoliosis" by A.A. Weening et al. Eur Spine J; DOI 10.1007/s00586-017-5066-y. ( 29948323 )
2018
36
Bone Mineral Density After Spinal Fusion Surgery for Adolescent Idiopathic Scoliosis at a Minimum 20-Year Follow-up. ( 29413740 )
2018
37
Blood Loss Trends and Financial Implications in Adolescent Idiopathic Scoliosis. ( 29979217 )
2018
38
CORR InsightsAr: Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389798 )
2018
39
Variation in Adolescent Idiopathic Scoliosis Surgery: Implications for Improving Healthcare Value. ( 29426688 )
2018
40
Additional Risk Factors for Adding-On After Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: Implication of Lowest Instrumented Vertebra Angle and Lumbosacral Takeoff. ( 29413739 )
2018
41
Prevalence of idiopathic scoliosis in anorexia nervosa patients: results from a cross-sectional study. ( 28601992 )
2018
42
The Duration of the correction loss after removing cheneau brace in patients with adolescent idiopathic scoliosis. ( 30459102 )
2018
43
Adolescent idiopathic scoliosis for the primary care physician: frequently asked questions. ( 30461512 )
2018
44
Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis. ( 30464226 )
2018
45
Postural control of individuals with spinal fusion for adolescent idiopathic scoliosis. ( 30465967 )
2018
46
APSS-ASJ Best Clinical Research Award: Is There a Difference between Patients' and Parents' Perception of Physical Appearance in Adolescent Idiopathic Scoliosis? ( 30472823 )
2018
47
Does the Severity of the Curve in Lenke 1 and 2 Adolescent Idiopathic Scoliosis Patients Affect the Distance and Position of the Aorta from Vertebra? ( 30475346 )
2018
48
Alterations of the gut microbiome and plasma proteome in Chinese patients with adolescent idiopathic scoliosis. ( 30481617 )
2018
49
Case-matched comparative analysis of spinal deformity correction in arthrogryposis multiplex congenita versus adolescent idiopathic scoliosis. ( 30485184 )
2018
50
Noncontact sports participation in adolescent idiopathic scoliosis: effects on parent-reported and patient-reported outcomes. ( 30489444 )
2018

Variations for Idiopathic Scoliosis

ClinVar genetic disease variations for Idiopathic Scoliosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CELSR2 NM_001408.2(CELSR2): c.6859G> A (p.Val2287Ile) single nucleotide variant Uncertain significance rs141489111 GRCh37 Chromosome 1, 109812092: 109812092
2 CELSR2 NM_001408.2(CELSR2): c.6859G> A (p.Val2287Ile) single nucleotide variant Uncertain significance rs141489111 GRCh38 Chromosome 1, 109269470: 109269470

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

Pathways related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.58 ACAN COL1A2 FBN1 MATN1

GO Terms for Idiopathic Scoliosis

Cellular components related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.26 ACAN COL1A2 FBN1 MATN1
2 collagen-containing extracellular matrix GO:0062023 8.92 ACAN COL1A2 FBN1 MATN1

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 camera-type eye development GO:0043010 9.33 CHD7 FBN1 MTNR1B
2 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.26 CALM1 CHD7
3 extracellular matrix organization GO:0030198 9.26 ACAN COL1A2 FBN1 MATN1
4 skeletal system development GO:0001501 8.92 ACAN CHD7 COL1A2 FBN1

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.55 ACAN CALM1 CELSR2 FBN1 MATN1
2 melatonin receptor activity GO:0008502 8.96 MTNR1A MTNR1B
3 extracellular matrix structural constituent GO:0005201 8.92 ACAN COL1A2 FBN1 MATN1

Sources for Idiopathic Scoliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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