Idiopathic Scoliosis

Categories: Bone diseases
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Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 11 5 14
Scoliosis Idiopathic 53


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Disease Ontology 11 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology: 11 A scoliosis with no known cause.

MalaCards based summary: Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to marfan syndrome and orthostatic intolerance. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Burn wound healing. The drugs Cyclobenzaprine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and spinal cord, and related phenotypes are Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation and muscle

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 marfan syndrome 30.2 FBN1 ELN COL1A2 CD36
2 orthostatic intolerance 30.1 NOS2 FBN1 ELN COL1A2
3 atrial heart septal defect 30.1 FBN1 ELN CHD7
4 ehlers-danlos syndrome 29.9 FBN1 ELN COL1A2 CD36
5 loeys-dietz syndrome 29.8 FBN1 ELN COL1A2
6 scoliosis 29.8 SNTG1 POC5 NOS1 MTNR1B LOC108228202 LBX1
7 distal arthrogryposis 29.7 FBN1 ELN COL1A2 ADGRG6
8 cerebral palsy 29.7 NOS2 NOS1 COL1A2 CD36
9 brittle bone disorder 29.6 FBN1 ELN COL1A2 CD36
10 vascular disease 29.0 NOS2 KRIT1 FBN1 ELN
11 scoliosis, isolated 1 12.0
12 scoliosis, isolated 3 11.4
13 gaze palsy, familial horizontal, with progressive scoliosis 1 11.1
14 scoliosis, isolated 2 11.0
15 scoliosis, isolated 4 11.0
16 scoliosis, isolated 5 11.0
17 back pain 10.8
18 syringomyelia 10.6
19 overgrowth syndrome 10.6
20 idiopathic syringomyelia 10.6
21 non-alcoholic steatohepatitis 10.5
22 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.5
23 pain agnosia 10.5
24 chiari malformation 10.5
25 charge syndrome 10.5
26 body mass index quantitative trait locus 1 10.5
27 scheuermann disease 10.5
28 bone mineral density quantitative trait locus 3 10.5
29 leptin deficiency or dysfunction 10.5
30 intervertebral disc disease 10.4
31 spondylolisthesis 10.4
32 rickets 10.4
33 degenerative disc disease 10.4
34 47 xxx syndrome 10.4
35 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.4
36 ataxia with vitamin e deficiency 10.4
37 spinal disease 10.4
38 tethered spinal cord syndrome 10.4
39 infantile scoliosis 10.4
40 twin anemia-polycythemia sequence 10.4
41 polykaryocytosis inducer 10.4
42 pneumothorax, primary spontaneous 10.3
43 tatton-brown-rahman syndrome 10.3
44 respiratory failure 10.3
45 pneumothorax 10.3
46 hand skill, relative 10.3
47 virus-associated trichodysplasia spinulosa 10.3
48 anterior cutaneous nerve entrapment syndrome 10.3
49 cartilage disease 10.3
50 radiculopathy 10.3

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:

Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

GenomeRNAi Phenotypes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 8.8 KRIT1 NOS1 NOS2

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.85 ADGRG6 CD36 CHD7 COL1A2 ELN FBN1
2 cardiovascular system MP:0005385 9.65 ADGRG6 CD36 CHD7 COL1A2 ELN FBN1
3 skeleton MP:0005390 9.32 ADGRG6 BNC2 CD36 CHD7 COL1A2 ELN

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Cyclobenzaprine Approved Phase 4 303-53-7 2895
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Thrombin Approved, Investigational Phase 4
Cefazolin Approved Phase 4 25953-19-9 33255
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
Caffeine Approved Phase 4 58-08-2 2519
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
Hydromorphone Approved, Illicit Phase 4 466-99-9, 71-68-1 5284570
13 Acetaminophen, hydrocodone drug combination Phase 4
14 Excitatory Amino Acid Antagonists Phase 4
15 Anesthetics, Intravenous Phase 4
16 Anesthetics, General Phase 4
17 Anesthetics, Dissociative Phase 4
18 Pharmaceutical Solutions Phase 4
19 Hemostatics Phase 4
20 Coagulants Phase 4
21 Bone wax Phase 4
22 Hypnotics and Sedatives Phase 4
23 Dialysis Solutions Phase 4
24 Analgesics Phase 4
25 Neurotransmitter Agents Phase 4
abobotulinumtoxinA Phase 4
27 Botulinum Toxins, Type A Phase 4
28 Botulinum Toxins Phase 4
29 Cholinergic Agents Phase 4
30 Central Nervous System Stimulants Phase 4
31 Phosphodiesterase Inhibitors Phase 4
32 Anesthetics, Local Phase 4
33 Anti-Arrhythmia Agents Phase 4
34 Sodium Channel Blockers Phase 4
35 Diuretics, Potassium Sparing Phase 4
36 Analgesics, Opioid Phase 4
37 Anesthetics Phase 4
38 Antineoplastic Agents, Hormonal Phase 4
39 Hormones Phase 4
40 Hormone Antagonists Phase 4
41 Antiemetics Phase 4
42 glucocorticoids Phase 4
43 Anti-Inflammatory Agents Phase 4
44 Gastrointestinal Agents Phase 4
45 Narcotics Phase 4
Calcium carbonate Approved, Investigational Phase 3 471-34-1
47 Anti-Ulcer Agents Phase 3
48 Antacids Phase 3
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
Acetaminophen Approved Phase 2 103-90-2 1983

Interventional clinical trials:

(show top 50) (show all 250)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Unknown status NCT02651324 Phase 4 Ketamine
2 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
3 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
4 Effectiveness Of Gelatin Matrix With Human Derived Thrombin On Blood Loss, Surgical Time, Hospital Stay And Complications In Adolescents Undergoing Spine Surgery For Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial. Completed NCT01451788 Phase 4
5 Comparison of Measured Versus Predicted Blood Propofol Concentrations During Total Intravenous Anaesthesia in Children Undergoing Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
6 Skeletal Muscle and Adipose Tissue Concentrations of Cefazolin Comparing Two Different Dosing Regimens During Pediatric Posterior Spinal Fusion Surgery Completed NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
7 Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents Completed NCT01325493 Phase 4 Ketamine;Normal Saline
8 Intravenous Lignocaine as an Analgesic Adjunct in Adolescent Idiopathic Scoliosis Surgery (IGNITE-AIS Study) Recruiting NCT04931433 Phase 4 Lignocaine;Normal saline
9 Dysport ® (abobotulinumtoxinA) as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis Recruiting NCT03935295 Phase 4 AbobotulinumtoxinA;Placebos
10 Oral Caffeine Decreases the Frequency of Opioid Demand in AIS Patients After Spinal Fusion Recruiting NCT04950660 Phase 4 Caffeine Tablet;Placebo
11 Intravenous Lidocaine to Reduce Postoperative Opioid Consumption and Improve Recovery After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Enrolling by invitation NCT03893318 Phase 4 IV lidocaine;Placebos
12 The Impact of Perioperative Steroid Dosing on the Acute Phase Response in Adolescent Idiopathic Scoliosis Not yet recruiting NCT05561725 Phase 4 Dexamethasone postoperative;Standard of Care
13 Identification of the Optimal Analgesic Dose of Intrathecal Hydromorphone for Pediatric Patients Undergoing Posterior Spine Surgery for Idiopathic Scoliosis Not yet recruiting NCT05552443 Phase 4 Hydromorphone 2.5 mcg/kg;Hydromorphone 2.75 mcg/kg;Hydromorphone 3 mcg/kg;Hydromorphone 3.25 mcg/kg;Hydromorphone 3.5 mcg/kg;Hydromorphone 4 mcg/kg;Hydromorphone 4.5 mcg/kg;Hydromorphone 5 mcg/kg
14 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Withdrawn NCT00768313 Phase 4
15 Can Calcium and Vitamin D Supplementation Improve Bone Mineral Density and Curve Progression in Girls With Adolescent Idiopathic Scoliosis? Completed NCT01103115 Phase 3
16 Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial Completed NCT01108211 Phase 3
17 Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children Recruiting NCT04069169 Phase 3 Lidocaine;Saline Solution
18 The Use of Perioperative Gabapentin in Adolescents Undergoing Posterior Spinal Fusion for Idiopathic Scoliosis to Prevent Chronic Postsurgical Pain, a Pilot Study. Withdrawn NCT03867240 Phase 3 Gabapentin
19 Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
20 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
21 The Efficacy of Intravenous Tranexamic Acid in Decreasing Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
22 Analgesia Following Posterior Spinal Fusion: Methadone vs Magnesium Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
23 Ultrasound Guided Erector Spinae Plane Block in Scoliotic Adolescents Undergoing Posterior Spine Instrumentation . A Randomized Controlled Trial Completed NCT03968146 Phase 2 Fentanyl;additional Fentanyl;Morphine;rescue Morphine;pethidine;Ketorolac;Acetaminophen
24 Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis Recruiting NCT04922983 Phase 2 Botulinum toxin type A
25 Blood Loss and Transfusion Requirement in Pediatric Patients With Non-Idiopathic Scoliosis Treated With Tranexamic Acid Undergoing Posterior Spinal Instrumentation and Fusion. Terminated NCT01089140 Phase 2 Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
26 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics During Static and Dynamic Activities in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
27 An Innovative Body-Mapping Tank Top Equipped With Biofeedback System for Adolescents With Early Scoliosis Completed NCT02471508 Phase 1
28 A Protocol of Accelerated Rehabilitation for Patients Undergoing Adolescent Idiopathic Scoliosis Correction Surgery - An Internal Pilot Study Unknown status NCT03719807
29 Investigation of The Effects of Scoliosis Specific Exercises Before Adolescent Idiopathic Scoliosis Surgery Unknown status NCT04357561
30 Ultrasound Guided Bilateral Retrolaminar Block as Analgesia for Adolescent Idiopathic Scoliosis Correction Unknown status NCT04336111
31 Ultrasound Guided Bilateral Erector Spinae Block as Analgesia for Adolescent Idiopathic Scoliosis Correction Unknown status NCT04336046 normal saline;Bupivacaine
32 Effect of the Severity and the Treatment (Orthosis Versus Surgery)of the Idiopathic Scoliosis on the Locomotor Mechanism of the Gait. Unknown status NCT00842218
33 Application Research of Physiotherapeutic Scoliosis Specific Exercises in Adolescent Idiopathic Scoliosis Unknown status NCT02968043
34 Treatment of Adolescent Idiopathic Scoliosis Patients Using the Ellipse MAGEC System Unknown status NCT01633931
35 Efficacy of Three-dimensionally Integrated Exercise for Scoliosis in Patients With Adolescent Idiopathic Scoliosis Unknown status NCT03427970
36 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245
37 Assesment of Enhanced Recovery After Pediatric Idiopathic Scoliosis Surgery Unknown status NCT04012528
38 Repeatability and Reproducibility of Low-dose Digital Radiographs in the Idiopathic Scoliosis Unknown status NCT03464318
39 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
40 Evaluation of Pain Following Scoliosis Surgery.- RACHIDOL Unknown status NCT03686371
41 Efficacy and Safety of Desmopressin Combined With Tranexamic Acid on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
42 Retrospective Review With Prospective Surveillance of Safety and Efficacy in a Clinical Series of Spinal Tethering Patients Unknown status NCT02897453
43 Effect of Ultra-short-term Treatment of Patients With Iron Deficiency or Anemia Undergoing Adolescent Scoliosis Correction Unknown status NCT04343170 Placebo;ferric carboxymaltose , α erythropoietin, vitamin B12, oral folic acid
44 Comparison of Preoperative 3D Spine Reconstruction With the EOS System and Peroperative 3D Spine Reconstruction With SURGIVISIO Unknown status NCT04611490
45 Prevalence of Myofascial Pain Syndrome in Adolescent Idiopathic Scoliosis and the Relationship Between Myofascial Pain Syndrome and Spinal Coronal and Sagittal Alignment in Adolescent Idiopathic Scoliosis Completed NCT05185050
46 Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients Completed NCT03820895
47 Leg Length Discrepancy and Adolescent Idiopathic Scoliosis: Clinical and Radiological Characteristics Completed NCT04713397
48 The Effect of Schroth Method on Pain, Body Awareness and Quality of Life in Adolescent Individuals With Idiopathic Scoliosis Completed NCT04689295
49 Evaluation of Virtual Reality Intervention After Pediatric Idiopathic Scoliosis Surgery to Reduce Postoperative Pain and Opioid Consumption Completed NCT04584970
50 Ultrasonographic Evaluation of Abdominal Muscle Thickness Symmetry and Correlation With Pulmonary Function Test in Adolescent Idiopathic Scoliosis Completed NCT04567914

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

Organs/tissues related to Idiopathic Scoliosis:

MalaCards : Bone, Skeletal Muscle, Spinal Cord, Lung, Bone Marrow, Brain, Pineal

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 8268)
# Title Authors PMID Year
Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. 53 62
17632395 2007
[Expression of calmodulin and nNOS in the paraspinal muscles in idiopathic scoliosis]. 53 62
15387945 2004
[Expression of neuronal nitric oxide synthase and inducible nitric oxide synthase in the erector spinal muscles in idiopathic scoliosis]. 53 62
15379275 2004
Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis. 53 62
8982144 1996
Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: A large-scale assessment by ultra-high-resolution micro-computed tomography. 62
36341948 2023
Cervical sagittal alignment is influenced by changes in thoracic and lumbar sagittal alignments after correction surgery in patients with lenke type 6 adolescent idiopathic scoliosis. 62
36147585 2022
Current models to understand the onset and progression of scoliotic deformities in adolescent idiopathic scoliosis: a systematic review. 62
36454530 2022
Risk factors for vertebral bridging in residual adolescent idiopathic scoliosis with thoracolumbar/lumbar curves. 62
36462997 2022
Ultrasound to X-ray synthesis generative attentional network (UXGAN) for adolescent idiopathic scoliosis. 62
35926252 2022
Providence nighttime brace is as effective as fulltime Boston brace for female patients with adolescent idiopathic scoliosis: A retrospective analysis of a randomized cohort. 62
36458131 2022
Bone mineral density in children and young adults with idiopathic scoliosis: a systematic review and meta-analysis. 62
36450863 2022
Melatonin and adolescent idiopathic scoliosis: The present evidence. 62
34489192 2022
The risk of delayed spinal cord injury in pediatric spinal deformity surgery. 62
36459389 2022
Response to the letter to the editor regarding, "Pulmonary function in children and adolescents with untreated idiopathic scoliosis: a systematic review with meta-regression analysis". 62
36089264 2022
Letter to the editor regarding "Pulmonary function in children and adolescents with untreated idiopathic scoliosis: a systematic review with meta-regression analysis". 62
36464413 2022
"Letter to the Editor: Treatment of infantile idiopathic scoliosis using a novel thoracolumbosacral orthosis: a case report". 62
36471436 2022
Risk factors and clinical impact of persistent coronal imbalance after posterior spinal fusion in thoracolumbar/lumbar idiopathic scoliosis. 62
35901689 2022
End of growth results of an optimised treatment for 40-degree idiopathic scoliosis at age 1: A case report. 62
35489686 2022
Early dynamic changes within the spine following posterior fusion using hybrid instrumentation in adolescents with idiopathic scoliosis: a gait analysis study. 62
34008049 2022
Outcomes of Posterior Spinal Fusion in Pediatric Patients with Down Syndrome. 62
36166508 2022
Three-dimensional correction of scoliosis by a double spring reduction system as a dynamic internal brace: a pre-clinical study in Göttingen minipigs. 62
36343914 2022
Reliability and Validity of the Adapted Chinese Version of the Quality of Life Profile for Spine Deformities in Adolescents With Idiopathic Scoliosis. 62
36355378 2022
The role of pineal gland volume in the development of scoliosis. 62
36374335 2022
3D Surface Topographic Optical Scans Yield Highly Reliable Global Spine Range of Motion Measurements in Scoliotic and Non-Scoliotic Adolescents. 62
36421205 2022
CT analysis of the posterior anatomical landmarks of the scoliotic spine. 62
36064659 2022
The Volume-Cost Relationship: How Does Surgical Volume Affect Cost and Value in AIS Surgery. 62
35509023 2022
Reliability and validity of an adapted Saudi Arabic version of scoliosis research society outcomes questionnaire (SRS-30) in Saudi Arabia. 62
36436116 2022
Outcome of bracing vs. surgical treatment in adolescents with idiopathic scoliosis based on device measured daily physical activity: a prospective pilot study. 62
36445379 2022
Indications and timing of revision spine surgery in adults after adolescent surgery for idiopathic scoliosis. 62
35695990 2022
Socioeconomic and geographic disparities in pediatric scoliosis surgery. 62
35841474 2022
Innovative technique for early-onset scoliosis casting using Jackson table. 62
35776363 2022
Bracing for juvenile idiopathic scoliosis: retrospective review from bracing to skeletal maturity. 62
35852786 2022
Morphological differences in scoliosis curvatures as a cause of difficulties in its early detection based on angle of trunk inclination. 62
36324093 2022
Intraoperative neuromonitoring in non-idiopathic pediatric scoliosis operated with minimally fusionless procedure: A series of 290 patients. 62
36167615 2022
Conditional inactivation of the L-type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice. 62
36161979 2022
Cross-cultural French-Canadian adaptation and psychometric assessment of the Italian Spine Youth Quality of Life (ISYQOL) questionnaire. 62
35870800 2022
Complication risks and costs associated with Ponte osteotomies in surgical treatment of adolescent idiopathic scoliosis: insights from a national database. 62
35810408 2022
Sport improved medium-term results in a prospective cohort of 785 adolescents with idiopathic scoliosis braced full time. SOSORT 2018 award winner. 62
36083351 2022
A case of chyluria with nephrotic-range proteinuria caused by lymphatic malformation, leading to a diagnosis of Klippel-Trenaunay syndrome. 62
36369386 2022
The Extension of Surgery Predicts Acute Postoperative Pain, While Persistent Postoperative Pain Is Related to the Spinal Pathology in Adolescents Undergoing Posterior Spinal Fusion. 62
36360457 2022
Clinical Application of the Roussouly Classification in the Sagittal Balance Reconstruction of 101 Adolescent Idiopathic Scoliosis Patients. 62
36398431 2022
Is the Integration Problem in the Sensoriomotor System the Cause of Adolescent Idiopathic Scoliosis? 62
36418290 2022
Restoration of thoracic kyphosis in adolescent idiopathic scoliosis with patient-specific rods: did the preoperative plan match postoperative sagittal alignment? 62
36357540 2022
Does the use of intrawound povidone-iodine irrigation and local vancomycin powder impact surgical site infection rate in adolescent idiopathic scoliosis surgery? 62
35913622 2022
The preliminary outcomes of vertebral body tethering in treating adolescent idiopathic scoliosis: a systematic review. 62
35841473 2022
Pulmonary function after thoracoplasty for adolescent idiopathic scoliosis: a systematic review and meta-analysis. 62
36069937 2022
Long-term outcome of patients with adolescent idiopathic scoliosis seeking nonoperative treatment after a mean follow-up of 42 years. 62
35819723 2022
The Effects of Body Mass Index and Spine Flexibility on Surgical Outcomes for Patients With Adolescent Idiopathic Scoliosis. 62
35913803 2022
Return to sport after posterior spinal fusion for adolescent idiopathic scoliosis: what variables actually have an influence? A retrospective study. 62
35723854 2022
Accuracy of thoracic pedicle screw placement in adolescent idiopathic scoliosis patients using the entry point identified by new landmarks: a computed tomography study. 62
36333715 2022

Variations for Idiopathic Scoliosis

ClinVar genetic disease variations for Idiopathic Scoliosis:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CELSR2 NM_001408.3(CELSR2):c.6859G>A (p.Val2287Ile) SNV Uncertain Significance
397652 rs141489111 GRCh37: 1:109812092-109812092
GRCh38: 1:109269470-109269470

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

Pathways related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.37 NOS2 COL1A2 CD36
2 10.67 FBN1 ELN COL1A2
3 10.64 NOS2 NOS1
4 10.07 NOS2 NOS1

GO Terms for Idiopathic Scoliosis

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 camera-type eye development GO:0043010 9.77 MTNR1B FBN1 CHD7
2 positive regulation of guanylate cyclase activity GO:0031284 9.71 NOS2 NOS1
3 cell redox homeostasis GO:0045454 9.63 NOS2 NOS1 KRIT1
4 extracellular matrix assembly GO:0085029 9.61 ELN COL1A2
5 arginine catabolic process GO:0006527 9.56 NOS2 NOS1
6 cellular biosynthetic process GO:0044249 9.32 NOS2 NOS1
7 peptidyl-cysteine S-nitrosylation GO:0018119 9.26 NOS2 NOS1
8 nitric oxide mediated signal transduction GO:0007263 9.1 NOS2 NOS1 CD36

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 9.56 FBN1 ELN
2 arginine binding GO:0034618 9.46 NOS2 NOS1
3 tetrahydrobiopterin binding GO:0034617 9.26 NOS2 NOS1
4 nitric-oxide synthase activity GO:0004517 8.92 NOS2 NOS1

Sources for Idiopathic Scoliosis

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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