MCID: IDP070
MIFTS: 39

Idiopathic Scoliosis

Categories: Bone diseases

Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 6 15
Scoliosis Idiopathic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to pectus excavatum and scoliosis. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2). The drugs Cyclobenzaprine and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 pectus excavatum 30.4 FBN1 ADGRG6
2 scoliosis 28.4 SNTG1 POC5 PAX1 MTNR1B LBX1 FBN1
3 scoliosis, isolated 1 12.5
4 scoliosis, isolated 3 12.1
5 horizontal gaze palsy with progressive scoliosis 11.6
6 scoliosis, isolated 2 11.5
7 scoliosis, isolated 4 11.5
8 scoliosis, isolated 5 11.5
9 back pain 10.8
10 overgrowth syndrome 10.5
11 syringomyelia, noncommunicating isolated 10.5
12 syringomyelia 10.5
13 non-alcoholic steatohepatitis 10.5
14 chiari malformation 10.4
15 bone mineral density quantitative trait locus 3 10.4
16 spondylolisthesis 10.4
17 body mass index quantitative trait locus 1 10.4
18 pain agnosia 10.4
19 respiratory failure 10.3
20 infantile scoliosis 10.3
21 hand skill, relative 10.3
22 47,xyy 10.3
23 rare isolated myopia 10.3 FBN1 CHD7
24 polykaryocytosis inducer 10.3
25 scheuermann disease 10.3
26 degenerative disc disease 10.3
27 spinal cord injury 10.3
28 virus-associated trichodysplasia spinulosa 10.3
29 spinal disease 10.2
30 myopathy 10.2
31 pneumothorax 10.2
32 chronic pain 10.2
33 chiari malformation type ii 10.2
34 orthostatic intolerance 10.2
35 ileus 10.2
36 48,xyyy 10.2
37 marfan syndrome 10.1
38 osteoporosis 10.1
39 bone mineral density quantitative trait locus 8 10.1
40 bone mineral density quantitative trait locus 15 10.1
41 leukemia, acute lymphoblastic 3 10.1
42 bone resorption disease 10.1
43 spondylolysis 10.1
44 neuromuscular disease 10.1
45 lung disease 10.1
46 pulmonary embolism 10.1
47 pathologic nystagmus 10.1
48 hypermobile ehlers-danlos syndrome 10.1
49 lipomatosis, multiple 10.1
50 thrombophilia due to thrombin defect 10.1

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:



Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 ADGRG6 BNC2 CELSR2 CHD7 COL1A2 FBN1
2 cardiovascular system MP:0005385 9.87 ADGRG6 CHD7 COL1A2 FBN1 LBX1 PAX1
3 limbs/digits/tail MP:0005371 9.63 CHD7 COL1A2 FBN1 LBX1 PAX1 VANGL1
4 muscle MP:0005369 9.43 ADGRG6 CHD7 COL1A2 FBN1 LBX1 PAX1
5 skeleton MP:0005390 9.17 ADGRG6 BNC2 CHD7 COL1A2 FBN1 PAX1

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclobenzaprine Approved Phase 4 303-53-7 2895
2
Thrombin Approved, Investigational Phase 4
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Tranexamic Acid Approved Phase 4 1197-18-8 5526
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
7
Cefazolin Approved Phase 4 25953-19-9 656510 33255
8
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
9
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
10
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12 Acetaminophen, hydrocodone drug combination Phase 4
13 Excitatory Amino Acid Antagonists Phase 4
14 Anesthetics, Dissociative Phase 4
15 Excitatory Amino Acids Phase 4
16 Coagulants Phase 4
17 Antifibrinolytic Agents Phase 4
18 Hemostatics Phase 4
19 Antimanic Agents Phase 4
20 Dialysis Solutions Phase 4
21 Anti-Bacterial Agents Phase 4
22 Anti-Infective Agents Phase 4
23 Tranquilizing Agents Phase 4
24 Anti-Anxiety Agents Phase 4
25 Psychotropic Drugs Phase 4
26 Anticonvulsants Phase 4
27 calcium channel blockers Phase 4
28 Anesthetics Phase 4
29 Anesthetics, Local Phase 4
30 Central Nervous System Depressants Phase 4
31 Peripheral Nervous System Agents Phase 4
32 Analgesics, Opioid Phase 4
33 Neurotransmitter Agents Phase 4
34 Pharmaceutical Solutions Phase 4
35 abobotulinumtoxinA Phase 4
36 Neuromuscular Agents Phase 4
37 Acetylcholine Release Inhibitors Phase 4
38 Cholinergic Agents Phase 4
39 Botulinum Toxins Phase 4
40 Botulinum Toxins, Type A Phase 4
41 Anti-Arrhythmia Agents Phase 4
42 Sodium Channel Blockers Phase 4
43 Diuretics, Potassium Sparing Phase 4
44
Calcium carbonate Approved, Investigational Phase 3 471-34-1
45
Clevidipine Approved, Investigational Phase 2, Phase 3 167221-71-8
46
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
47
Methadone Approved, Illicit Phase 3 76-99-3 4095
48 Antacids Phase 3
49 Gastrointestinal Agents Phase 3
50 Anti-Ulcer Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 156)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Unknown status NCT02651324 Phase 4 Ketamine
2 Effectiveness Of Gelatin Matrix With Human Derived Thrombin On Blood Loss, Surgical Time, Hospital Stay And Complications In Adolescents Undergoing Spine Surgery For Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial. Unknown status NCT01451788 Phase 4
3 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
4 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
5 Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents Completed NCT01325493 Phase 4 Ketamine;Normal Saline
6 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
7 Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction Completed NCT01977937 Phase 4 Gabapentin 250mg/5mL NDC:59762-5025-01;Simple Syrup
8 A Prospective, Randomized, Double-blinded Single-site Control Study Comparing Blood Loss Prevention of Tranexamic Acid (TXA) to Epsilon Aminocaproic Acid (EACA) for Corrective Spinal Surgery Completed NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
9 Skeletal Muscle and Adipose Tissue Concentrations of Cefazolin Comparing Two Different Dosing Regimens During Pediatric Posterior Spinal Fusion Surgery Recruiting NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
10 Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery. Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
11 The Use of Botulinum Toxin A Injections As An Adjunct to Bracing to Treat Adolescent Idiopathic Scoliosis Not yet recruiting NCT03935295 Phase 4 AbobotulinumtoxinA;Placebos
12 Intravenous Lidocaine to Reduce Postoperative Opioid Consumption and Improve Recovery After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Not yet recruiting NCT03893318 Phase 4 IV lidocaine;Placebos
13 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
14 Perioperative Outcomes of Multilevel Posterior Spinal Fusion in Adolescent Scoliosis With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
15 Can Calcium and Vitamin D Supplementation Improve Bone Mineral Density and Curve Progression in Girls With Adolescent Idiopathic Scoliosis? Completed NCT01103115 Phase 3
16 Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial Completed NCT01108211 Phase 3
17 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
18 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
19 Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children. Completed NCT00323752 Phase 3
20 The Use of Perioperative Gabapentin in Adolescents Undergoing Posterior Spinal Fusion for Idiopathic Scoliosis to Prevent Chronic Postsurgical Pain, a Pilot Study. Recruiting NCT03867240 Phase 3 Gabapentin
21 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Recruiting NCT02558010 Phase 3 Methadone;Morphine
22 The Effects of Fibrinogen Concentrate Infusion on Perioperative Blood Loss and Allogeneic Blood Conservation in Patients Undergoing Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
23 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Active, not recruiting NCT02285621 Phase 3
24 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
25 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
26 The Efficacy of Intravenous Tranexamic Acid in Decreasing Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
27 Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
28 Analgesia Following Posterior Spinal Fusion: Methadone vs Magnesium Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
29 Ultrasound Guided Erector Spinae Plane Block in Scoliotic Adolescents Undergoing Posterior Spine Instrumentation . A Randomized Controlled Trial Not yet recruiting NCT03968146 Phase 2 Fentanyl;additional Fentanyl;Morphine;rescue Morphine;pethidine;Ketorolac;Acetaminophen
30 Blood Loss and Transfusion Requirement in Pediatric Patients With Non-Idiopathic Scoliosis Treated With Tranexamic Acid Undergoing Posterior Spinal Instrumentation and Fusion. Terminated NCT01089140 Phase 2 Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
31 An Innovative Body-Mapping Tank Top Equipped With Biofeedback System for Adolescents With Early Scoliosis Completed NCT02471508 Phase 1
32 Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery Completed NCT00357851 Phase 1 Aprotinin
33 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245
34 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
35 Effect of the Severity and the Treatment (Orthosis Versus Surgery)of the Idiopathic Scoliosis on the Locomotor Mechanism of the Gait. Unknown status NCT00842218
36 A Randomized Controlled Trial: Comparison of a Top Loading MESA® Spinal System With MESA Rail™ and a Side Locking Pedicle Screw System for the Treatment of Adolescent Paediatric Spine Deformity Unknown status NCT02590380
37 Efficacy and Safety of Desmopressin Combined With Tranexamic Acid on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
38 Scoliosis-Specific Exercises for At-Risk Mild Adolescent Idiopathic Scoliosis Curves: A Multi-Site Preliminary Randomized Trial Unknown status NCT02807545
39 Idiopathic Scoliosis Treated by Posterior Spinal Instrumentation. Evaluation of the 3D Correction, Aesthetic Outcomes and Quality of Life. Completed NCT01019109
40 Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Completed NCT03539770
41 Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients Completed NCT03820895
42 Idiopathic Scoliosis Surgery in Adolescents ; Earnings a Multidisciplinary Management of Pain and Quality of Life Completed NCT02890654
43 Effect of Conservative Treatment on Pulmonary Functions, Gait Oxygen Consumption Balance and Lower Limb Load Distribution in Adolescents With Idiopathic Scoliosis Completed NCT03514082
44 Evaluation of an Anesthetic Optimization Technique in Adolescent Idiopathic Scoliosis Surgery Completed NCT02481570
45 The Effect of Core Stabilization Training on Respiratory Parameters, Peripheral Muscle Strength, Balance, Functional Capacity and Quality of Life in Children With Adolescent Idiopathic Scoliosis Completed NCT03823053
46 The Effect of the Inspiratory Muscle Training on Respiratory Muscle Strength, Respiratory Function and Functional Capacity in Adolescents With Idiopathic Scoliosis Completed NCT03391895
47 A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace Completed NCT01336114
48 Prospective Study: Long-Term Pulmonary Function, Health-Related Quality of Life, and Sagittal Plane Alignment Following the Treatment of Pediatric Scoliosis Completed NCT01760434
49 Short-term Effects of the Simultaneous Use of Two Physiotherapeutic Methods in the Treatment of Adolescent Idiopathic Scoliosis - Pilot Study Completed NCT01250860
50 Single-blind Comprehensive Cohort Study Incorporating a Randomized Controlled Design on Bracing in AIS: A Feasibility Study Completed NCT00989495

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

MalaCards organs/tissues related to Idiopathic Scoliosis:

41
Bone, Testes, Spinal Cord, Lung, Brain, Skeletal Muscle, Breast

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 6541)
# Title Authors PMID Year
1
Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. 9 38
17632395 2007
2
[Expression of calmodulin and nNOS in the paraspinal muscles in idiopathic scoliosis]. 9 38
15387945 2004
3
[Expression of neuronal nitric oxide synthase and inducible nitric oxide synthase in the erector spinal muscles in idiopathic scoliosis]. 9 38
15379275 2004
4
Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis. 9 38
8982144 1996
5
The Amount of Relative Curve Correction Is More Important Than Upper Instrumented Vertebra Selection for Ensuring Postoperative Shoulder Balance in Lenke Type 1 and Type 2 Adolescent Idiopathic Scoliosis. 38
31261265 2019
6
An ontology-based module of the information system ScolioMedIS for 3D digital diagnosis of adolescent scoliosis. 38
31416553 2019
7
Minimal invasive posterior correction of Lenke 5C idiopathic scoliosis: comparative analysis of minimal invasive vs. open surgery. 38
30874895 2019
8
Congenital Etiology Is an Independent Risk Factor for Complications in Adolescents Undergoing Corrective Scoliosis Surgery: Comparison of In-hospital Comorbidities Using Nationwide KID's Inpatient Database. 38
31393299 2019
9
When Should We Wean Bracing for Adolescent Idiopathic Scoliosis? 38
31135558 2019
10
Effect of Direct Vertebral Rotation in Single Thoracic Adolescent Idiopathic Scoliosis: Better 3-Dimensional Deformity Correction. 38
31150860 2019
11
The Perioperative Efficacy and Safety of Tranexamic Acid in Adolescent Idiopathic Scoliosis. 38
31176837 2019
12
CORR Insights®: When Should We Wean Bracing for Adolescent Idiopathic Scoliosis? 38
31283729 2019
13
Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis. 38
30464226 2019
14
A three-dimensional analysis of scoliosis progression in non-idiopathic scoliosis: is it similar to adolescent idiopathic scoliosis? 38
31183529 2019
15
Analysis of the interface pressure exerted by the Chêneau brace in patients with double-curve adolescent idiopathic scoliosis. 38
31244368 2019
16
Sagittal Alignment Profile Following Selective Thoracolumbar/Lumbar Fusion in Patients With Lenke Type 5C Adolescent Idiopathic Scoliosis. 38
30921290 2019
17
We Enjoy Operating for Adolescent Idiopathic Scoliosis, but Do We Help the Patients?: Commentary on an article by Linda Helenius, MD, et al.: "Back Pain and Quality of Life After Surgical Treatment for Adolescent Idiopathic Scoliosis at 5-Year Follow-up. Comparison with Healthy Controls and Patients with Untreated Idiopathic Scoliosis". 38
31436667 2019
18
Asymmetric Three Column Osteotomy for Coronal Malalignment in Adult Patients with Prior Thoracic Fusion for Adolescent Idiopathic Scoliosis: Three Year Follow-up. 38
31382065 2019
19
The minimum detectable measurement difference for the Scoliosis Research Society-22r in adolescent idiopathic scoliosis: a comparison with the minimum clinically important difference. 38
30986576 2019
20
Correlation of Lower Instrumented Vertebra With Spinal Mobility and Health-related Quality of Life After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. 38
31361270 2019
21
Could the Clinical Effectiveness Be Improved Under the Integration of Orthotic Intervention and Scoliosis-Specific Exercise in Managing Adolescent Idiopathic Scoliosis?: A Randomized Controlled Trial Study. 38
31318743 2019
22
Back Pain and Quality of Life After Surgical Treatment for Adolescent Idiopathic Scoliosis at 5-Year Follow-up: Comparison with Healthy Controls and Patients with Untreated Idiopathic Scoliosis. 38
31436653 2019
23
Common Elements in Surgical Site Infection Care Bundles for Adolescent Idiopathic Scoliosis at North American Pediatric Institutions: A Survey of POSNA QSVI Challenge Participants. 38
31157753 2019
24
An Overview of the Current State of Pediatric Scoliosis Management. 38
31416110 2019
25
Periapical Wires Result in Less Curve Correction Than Pedicle Screw Constructs in Idiopathic Scoliosis. 38
31422646 2019
26
In-brace alterations of pulmonary functions in adolescents wearing a brace for idiopathic scoliosis. 38
30945977 2019
27
The Effect of Bracing on Spinopelvic Rotation and Psychosocial Parameters in Adolescents with Idiopathic Scoliosis. 38
31434463 2019
28
Is Radiation-Free Ultrasound Accurate for Quantitative Assessment of Spinal Deformity in Idiopathic Scoliosis (IS): A Detailed Analysis With EOS Radiography on 952 Patients. 38
31399250 2019
29
The Italian Spine Youth Quality of Life questionnaire measures health-related quality of life of adolescents with spinal deformities better than the reference standard, the Scoliosis Research Society 22 questionnaire. 38
30977381 2019
30
One-Stage Posterior Multiple Levels Asymmetrical Ponte Osteotomies vs. Single Level Posterior Vertebral Column Resection for Severe and Rigid Adult Idiopathic Scoliosis: A Minimum 2-year Follow-up Comparative Study. 38
31415466 2019
31
Clinical photography in severe idiopathic scoliosis candidate for surgery: is it a useful tool to differentiate among Lenke patterns? 38
31396690 2019
32
The FED-Method (Fixation, Elongation, Derotation) - a Machine-supported Treatment Approach to Patients with Idiopathic Scoliosis - Systematic Review. 38
31404938 2019
33
Long-term Results of Conservative Therapy of Adolescent Idiopathic Scoliosis Using the Cheneau Brace. 38
31408904 2019
34
High Satisfaction in Adolescent Idiopathic Scoliosis Patients on Enhanced Discharge Pathway. 38
31403990 2019
35
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese. 38
31417091 2019
36
Long-Term Follow-Up of Anterior Spinal Fusion for Thoracolumbar/Lumbar Curves in Adolescent Idiopathic Scoliosis. 38
30896585 2019
37
Concomitant low-grade isthmic L5-spondylolisthesis does not affect the course of adolescent idiopathic scoliosis. 38
31375986 2019
38
Muscular Contribution to Adolescent Idiopathic Scoliosis from the Perspective of Stem Cell-Based Regenerative Medicine. 38
31170887 2019
39
Ghrelin up-regulates cartilage-specific genes via the ERK/STAT3 pathway in chondrocytes of patients with adolescent idiopathic scoliosis. 38
31421834 2019
40
Impact of patient and hospital-level risk factors on extended length of stay following spinal fusion for adolescent idiopathic scoliosis. 38
31374544 2019
41
Answer to the Letter to the Editor of Weiss HR et al. concerning "Head to pelvis alignment of adolescent idiopathic scoliosis patients both in and out of brace" by Vergari C, Courtois I, Ebermeyer E, Pietton R, Bouloussa H, Vialle R, Skalli W (Eur Spine J; 2019: https://doi.org/10.1007/s00586-019-05981-8). 38
31321543 2019
42
Reciprocal Change in Sagittal Profiles after Adolescent Idiopathic Scoliosis Surgery with Segmental Pedicle Screw Construct: A Full-Body X-ray Analysis. 38
31348179 2019
43
The Reliability of Intraoperative Crossbar Technique in Determining the Upper Instrumented Vertebra (UIV) Tilt Angle for Adolescent Idiopathic Scoliosis (AIS) Undergoing Posterior Spinal Fusion. 38
30640749 2019
44
Flexibility of the thoracic curve and three-dimensional thoracic kyphosis can predict pulmonary function in nonoperatively treated adult patients with adolescent idiopathic scoliosis. 38
31303435 2019
45
The Sagittal Thoracic Modifier Component of the Lenke Classification System in Moderate and Severe Adolescent Idiopathic Scoliosis: Reliability and Reproducibility of Measurements Among 5 Observers. 38
30807366 2019
46
Health-related Quality of Life and Postural Changes of Spinal Alignment in Female Adolescents Associated With Back Pain in Adolescent Idiopathic Scoliosis: A Prospective Cross-sectional Study. 38
30817729 2019
47
Do postoperative drain volumes correlate with intraoperative blood loss and postoperative transfusion requirements in posterior spinal fusion for adolescent idiopathic scoliosis? 38
30431538 2019
48
Assessment of fatty infiltration of the multifidus muscle in patients with adolescent idiopathic scoliosis through evaluation by magnetic resonance imaging compared with histological analysis: a diagnostic accuracy study. 38
30543559 2019
49
Patients with adolescent idiopathic scoliosis perceive positive improvements regardless of change in the Cobb angle - Results from a randomized controlled trial comparing a 6-month Schroth intervention added to standard care and standard care alone. SOSORT 2018 Award winner. 38
31286903 2019
50
Frequency coherence analysis of postural balance in able-bodied and in non-treated adolescent idiopathic scoliotic girls. 38
31158728 2019

Variations for Idiopathic Scoliosis

ClinVar genetic disease variations for Idiopathic Scoliosis:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CELSR2 NM_001408.3(CELSR2): c.6859G> A (p.Val2287Ile) single nucleotide variant Uncertain significance rs141489111 1:109812092-109812092 1:109269470-109269470

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

GO Terms for Idiopathic Scoliosis

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood vessel development GO:0001568 9.26 COL1A2 CHD7
2 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.16 VANGL1 CELSR2
3 camera-type eye development GO:0043010 9.13 MTNR1B FBN1 CHD7
4 skeletal system development GO:0001501 8.92 PAX1 FBN1 COL1A2 CHD7

Sources for Idiopathic Scoliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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