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MCID: IDP070
MIFTS: 40

Idiopathic Scoliosis

Categories: Bone diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Idiopathic Scoliosis

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MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 6 15
Scoliosis Idiopathic 56

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060250
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Summaries for Idiopathic Scoliosis

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Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to pectus excavatum and scoliosis. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2), and among its related pathways/superpathways is Degradation of the extracellular matrix. The drugs Thrombin and Morphine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung.

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Related Diseases for Idiopathic Scoliosis

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Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 pectus excavatum 29.7 ACAN ADGRG6 FBN1
2 scoliosis 28.4 ACAN ADGRG6 BNC2 CALM1 CELSR2 CHD7
3 scoliosis, isolated 1 12.4
4 scoliosis, isolated 3 12.0
5 horizontal gaze palsy with progressive scoliosis 11.2
6 scoliosis, isolated 2 11.1
7 scoliosis, isolated 4 11.1
8 scoliosis, isolated 5 11.1
9 body mass index quantitative trait locus 1 10.3
10 syringomyelia 10.2
11 spondylolisthesis 10.2
12 disease of mental health 10.2
13 rare isolated myopia 10.1 CHD7 FBN1
14 bone mineral density quantitative trait locus 3 10.1
15 pseudoarthrosis 10.1
16 chiari malformation 10.1
17 degos 'en cocarde' erythrokeratoderma 10.1
18 gangliocytoma 10.0
19 ganglioneuroma 10.0
20 hypermobile ehlers-danlos syndrome 10.0
21 stiff skin syndrome 10.0 COL1A2 FBN1
22 scleroderma, familial progressive 10.0 COL1A2 FBN1
23 marfan syndrome 9.9
24 osteoporosis 9.9
25 orthostatic intolerance 9.9
26 intraocular pressure quantitative trait locus 9.9
27 blood group, junior system 9.9
28 osteoblastoma 9.9
29 pain agnosia 9.9
30 spondylolysis 9.9
31 myopathy 9.9
32 pancreatitis 9.9
33 dystonia 9.9
34 eating disorder 9.9
35 pathologic nystagmus 9.9
36 bone structure disease 9.9 ACAN ADGRG6 LBX1
37 exotropia 9.8 ACAN FBN1
38 spondyloarthropathy 1 9.8
39 radin blood group antigen 9.8
40 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 9.8
41 motion sickness 9.8
42 neurofibromatosis, type i 9.8
43 neurofibromatosis, type iv, of riccardi 9.8
44 polykaryocytosis inducer 9.8
45 scheuermann disease 9.8
46 schizophrenia 9.8
47 neural tube defects 9.8
48 thrombophilia due to thrombin defect 9.8
49 digeorge syndrome 9.8
50 varicose veins 9.8

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:



Diseases related to Idiopathic Scoliosis
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Symptoms & Phenotypes for Idiopathic Scoliosis

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Drugs & Therapeutics for Idiopathic Scoliosis

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Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
3
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
4
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
5
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
6
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
7
Cefazolin Approved Phase 4 25953-19-9 33255 656510
8
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
9
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
10
Cyclobenzaprine Approved Phase 4 303-53-7 2895
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
13
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
14
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
15
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
16 Hemostatics Phase 4,Phase 1,Phase 2,Not Applicable
17 Coagulants Phase 4,Phase 1,Phase 2,Not Applicable
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
19 Analgesics, Opioid Phase 4,Phase 2
20 Analgesics Phase 4,Phase 3,Phase 2
21 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
22 Narcotics Phase 4,Phase 2
23 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
24 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
25 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
26 Anesthetics Phase 4,Phase 1,Phase 2,Not Applicable
27 Anesthetics, General Phase 4,Phase 1,Phase 2,Not Applicable
28 Anesthetics, Intravenous Phase 4,Phase 2,Not Applicable
29 Anesthetics, Dissociative Phase 4,Phase 2
30 Anesthetics, Local Phase 4
31 Hypnotics and Sedatives Phase 4,Not Applicable
32 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
33 Anti-Anxiety Agents Phase 4,Phase 3
34 Tranquilizing Agents Phase 4,Phase 3
35 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
36 Psychotropic Drugs Phase 4,Phase 3
37 calcium channel blockers Phase 4,Phase 2,Phase 3
38 Anticonvulsants Phase 4,Phase 3,Phase 2
39 Anti-Arrhythmia Agents Phase 4,Phase 2
40 Pharmaceutical Solutions Phase 4,Phase 3
41 Anti-Bacterial Agents Phase 4
42 Anti-Infective Agents Phase 4
43 Dialysis Solutions Phase 4
44 Acetaminophen, hydrocodone drug combination Phase 4
45 Acetylcholine Release Inhibitors Phase 4
46 Neuromuscular Agents Phase 4
47 Botulinum Toxins, Type A Phase 4
48 abobotulinumtoxinA Phase 4
49 Cholinergic Agents Phase 4
50 Botulinum Toxins Phase 4

Interventional clinical trials:

(show top 50) (show all 147)
# Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
3 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
4 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
5 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
6 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
7 Skeletal Muscle and Adipose Tissue Study Recruiting NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
8 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
9 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Active, not recruiting NCT02651324 Phase 4 Ketamine
10 The Use of Botulinum Toxin A Injections As An Adjunct to Bracing to Treat Adolescent Idiopathic Scoliosis Not yet recruiting NCT03935295 Phase 4 AbobotulinumtoxinA;Placebos
11 IV Lidocaine in Pediatric AIS Not yet recruiting NCT03893318 Phase 4 IV lidocaine;Placebos
12 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
13 Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01103115 Phase 3
14 Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01108211 Phase 3
15 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
16 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
17 The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
18 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Active, not recruiting NCT02285621 Phase 3
19 Gabapentin and Chronic Post Surgical Pain Not yet recruiting NCT03867240 Phase 3 Gabapentin
20 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
21 Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
22 Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis Completed NCT00273598 Phase 2
23 Methadone vs Magnesium in Spinal Fusion Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
24 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
25 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
26 Safety and Efficacy of Body-mapping Tank Top Equipped With Biofeedback System for Adolescent With Early Scoliosis Completed NCT02471508 Phase 1
27 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
28 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245 Not Applicable
29 Scoliosis-Specific Exercises for At-Risk AIS Curves Unknown status NCT02807545 Not Applicable
30 The Idiopathic Scoliosis and Its Treatment (Orthopaedic and Surgery): Effect of the Severity, the Orthosis and the Arthrodesis on the Gait Unknown status NCT00842218
31 Study of DDAVP Combined With TXA on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 Not Applicable tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
32 Yoga in the Treatment of Adolescent Idiopathic and Degenerative Scoliosis Unknown status NCT03110965 Not Applicable
33 Three-dimensional Effects of Bracing in Adolescent Idiopathic Scoliosis Completed NCT03298256
34 Oxygen Consumption in Adolescent Idiopathic Scoliosis Completed NCT03514082
35 The Effect of the Inspiratory Muscle Training on Respiratory Parameters and Functional Capacity in Idiopathic Scoliosis Completed NCT03391895 Not Applicable
36 Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Completed NCT03539770
37 Prediction of 3D Effect of Brace in Idiopathic Scoliosis Treatment Using EOS Imaging System and "Anatomic Transfer". Completed NCT03209752
38 The Comparison of Core Stabilization Exercise With Scientific Exercise Approach to Scoliosis in Idiopathic Scoliosis Completed NCT02978820 Not Applicable
39 Effect of Compliance Counseling on Brace Success in Patients With Idiopathic Scoliosis Completed NCT02412137 Early Phase 1
40 Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA) Completed NCT02302534 Not Applicable
41 Gait and Postural Stability Assessment in Children With Idiopathic Scoliosis Undergoing Posterior Spine Instrumentation Completed NCT01109082
42 An Aerobic Exercising Program on Respiratory Muscle Strength in Patients With Adolescent Idiopathic Scoliosis Completed NCT00886652 Not Applicable
43 Spinal Stabilization Exercises for Low Back Pain in Adolescents With Idiopathic Scoliosis Completed NCT01550497 Not Applicable
44 Ghrelin Resistance in Adolescents With Idiopathic Scoliosis Completed NCT02829476 Not Applicable
45 Vitamin D Levels in Adolescent Idiopathic Scoliosis Completed NCT03820895
46 Effectiveness of Exercises in Adolescent Idiopathic Scoliosis Completed NCT02552615 Not Applicable
47 Evaluate Initial Safety of the HemiBridge™ System in Guided Spinal Growth Treatment of Progressive Idiopathic Scoliosis Completed NCT01465295 Not Applicable
48 Impact of the Choice of the Distal Vertebral in the Surgery of the Thoracic Adolescent Idiopathic Scoliosis Completed NCT02791776 Not Applicable
49 Scoliosis Surgery Using the PASS® LP System Completed NCT01019109
50 Anesthetic Optimization in Scoliosis Surgery Completed NCT02481570 Not Applicable

Search NIH Clinical Center for Idiopathic Scoliosis

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Genetic Tests for Idiopathic Scoliosis

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Anatomical Context for Idiopathic Scoliosis

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MalaCards organs/tissues related to Idiopathic Scoliosis:

42
Bone, Testes, Lung, Spinal Cord, Brain, Breast, Skeletal Muscle
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Publications for Idiopathic Scoliosis

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Articles related to Idiopathic Scoliosis:

(show top 50) (show all 3379)
# Title Authors Year
1
Extent of Depression in Juvenile and Adolescent Idiopathic Scoliosis Patients during Treatment with Braces. ( 30703588 )
2019
2
Clinical Relevance of Preoperative MRI in Adolescent Idiopathic Scoliosis: Is Hydromyelia a Predictive Factor of Intraoperative Electrophysiological Monitoring Alterations? ( 30913042 )
2019
3
Patients With Idiopathic Scoliosis Run an Increased Risk of Schizophrenia. ( 30660220 )
2019
4
Corrigendum to: Agreement Between Manual and Computerized Designation of Neutral Vertebra in Idiopathic Scoliosis [Spine Deformity 6/6 (2018) 644-650]. ( 30660240 )
2019
5
Accuracy of photogrammetry for detecting adolescent idiopathic scoliosis progression. ( 30661515 )
2019
6
Quantitative analysis of local bone graft harvested from the posterior elements during posterior spinal fusion in Adolescent Idiopathic Scoliosis patients. ( 30662243 )
2019
7
Surgical Outcomes of Anterior Versus Posterior Fusion in Lenke Type 1 Adolescent Idiopathic Scoliosis. ( 30664096 )
2019
8
Differential rod contouring on thoracolumbar/lumbar curvature in patients with adolescent idiopathic scoliosis: An analysis with intraoperative acquisition of three-dimensional imaging. ( 30683452 )
2019
9
Effect of Preoperative SpineCor® Treatment on Surgical Outcome in Idiopathic Scoliosis: An Observational Study. ( 30684354 )
2019
10
Postoperative Lumbar Curve Progression Deteriorates Shoulder Imbalance in Patients with Lenke Type 2B/C Adolescent Idiopathic Scoliosis Who Underwent Selective Thoracic Fusion. ( 30684704 )
2019
11
Anterior Spinal Overgrowth of the Thoracic Spine May Not Be Involved in the Initiation of Adolescent Idiopathic Scoliosis. ( 30685373 )
2019
12
Diurnal variation of body height in children with idiopathic scoliosis. ( 30689550 )
2019
13
Incidence and Risk Factors for Proximal Junctional Kyphosis in Adolescent Idiopathic Scoliosis After Correction Surgery: A Meta-Analysis. ( 30690145 )
2019
14
Manual therapy treatment for adolescent idiopathic scoliosis. ( 30691751 )
2019
15
Anatomical reference marks, evaluation parameters and reproducibility of surface topography for evaluating the adolescent idiopathic scoliosis: a systematic review with meta-analysis. ( 30708093 )
2019
16
Effect of thoracic kyphosis formation and rotational correction by direct vertebral rotation after the simultaneous double rod rotation technique for idiopathic scoliosis. ( 30711765 )
2019
17
A prospective analysis of motion and deformity at the shoulder level in surgically treated adolescent idiopathic scoliosis. ( 30721841 )
2019
18
Correction to: The "Risser+" grade: a new grading system to classify skeletal maturity in idiopathic scoliosis. ( 30725228 )
2019
19
Non-ionizing method of screening adolescent idiopathic scoliosis in schoolchildren. ( 30726384 )
2019
20
Incidence and Risk Factors of Cardiac Abnormalities in Patients with Idiopathic Scoliosis. ( 30738943 )
2019
21
Long-term follow-up after surgical treatment of adolescent idiopathic scoliosis using high-density pedicle screw constructs: Is 5-year routine visit required? ( 30741338 )
2019
22
Etiology of Adolescent Idiopathic Scoliosis: A Literature Review. ( 30744305 )
2019
23
A New Look at Causal Factors of Idiopathic Scoliosis: Altered Expression of Genes Controlling Chondroitin Sulfate Sulfation and Corresponding Changes in Protein Synthesis in Vertebral Body Growth Plates. ( 30745802 )
2019
24
Association between lay perception of morbidity and appropriateness of specialized health care use in Adolescent Idiopathic Scoliosis. ( 30756421 )
2019
25
Could the clinical effectiveness be improved under the integration of orthotic intervention and scoliosis specific exercise in managing adolescent idiopathic scoliosis? -A randomized controlled trial study. ( 30768449 )
2019
26
Increased acute postoperative wound problems following spinal fusion in overweight patients with adolescent idiopathic scoliosis. ( 30768579 )
2019
27
COMPARISON OF IMPLANT DENSITY IN THE MANAGEMENT OF LENKE 1B AND 1C ADOLESCENT IDIOPATHIC SCOLIOSIS. ( 30774527 )
2019
28
ROTATION ASSESSMENT IN ADOLESCENT IDIOPATHIC SCOLIOSIS WITH ROD DEROTATION. ( 30774529 )
2019
29
Can posterior implant removal prevent device-related vertebral osteopenia after posterior fusion in adolescent idiopathic scoliosis? A mean 29-year follow-up study. ( 30783802 )
2019
30
A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis. ( 30787423 )
2019
31
Management of Adolescent Idiopathic Scoliosis: Institutional Experience, Integration into Neurosurgical Practice, and Impact on Resident Training. ( 30797921 )
2019
32
Progressive decline in pulmonary function 5 years post-operatively in patients who underwent anterior instrumentation for surgical correction of adolescent idiopathic scoliosis. ( 30798454 )
2019
33
Association between perioperative surgical home implementation and transfusion patterns in adolescents with idiopathic scoliosis undergoing spinal fusion. ( 30801879 )
2019
34
The Sagittal Thoracic Modifier Component of the Lenke Classification System in Moderate and Severe Adolescent Idiopathic Scoliosis: Reliability and Reproducibility of Measurements Among 5 Observers. ( 30807366 )
2019
35
Health-Related Quality of Life and Postural Changes of Spinal Alignment in Female Adolescents Associated with Back Pain in Adolescent Idiopathic Scoliosis - A Prospective Cross-Sectional Study. ( 30817729 )
2019
36
Development of a multibody model to assess efforts along the spine for the rehabilitation of adolescents with idiopathic scoliosis. ( 30839298 )
2019
37
Editor's Spotlight/Take 5: How Common Is Back Pain and What Biopsychosocial Factors Are Associated With Back Pain in Patients With Adolescent Idiopathic Scoliosis? ( 30844831 )
2019
38
Adolescent idiopathic scoliosis associated POC5 mutation impairs cell cycle, cilia length and centrosome protein interactions. ( 30845169 )
2019
39
Predicting lowest hemoglobin level and risk of blood transfusion in spinal fusion surgery for adolescent idiopathic scoliosis. ( 30848365 )
2019
40
Customized k-nearest neighbourhood analysis in the management of adolescent idiopathic scoliosis using 3D markerless asymmetry analysis. ( 30849240 )
2019
41
Comparison of the accuracy of cannulated pedicle screw versus conventional pedicle screw in the treatment of adolescent idiopathic scoliosis: A randomized retrospective study. ( 30855502 )
2019
42
Investigating Role of IRX Family in Development of Female Adolescent Idiopathic Scoliosis: Which One Is Real Cause? ( 30862593 )
2019
43
The creation of a national coalition to target adolescent idiopathic scoliosis: a meeting report. ( 30863194 )
2019
44
Brace treatment in adolescent idiopathic scoliosis patients with curve more than 40 degrees: effectiveness and related factors. ( 30872192 )
2019
45
Minimal invasive posterior correction of Lenke 5C idiopathic scoliosis: comparative analysis of minimal invasive vs. open surgery. ( 30874895 )
2019
46
Preoperative assessment of idiopathic scoliosis in adolescent and young adult with three-dimensional T2-weighted spin-echo MRI. ( 30878467 )
2019
47
A Genetic Variant in GPR126 Causing a Decreased Inclusion of Exon 6 Is Associated with Cartilage Development in Adolescent Idiopathic Scoliosis Population. ( 30886859 )
2019
48
The Biomechanics of Induction in Adolescent Idiopathic Scoliosis: Theoretical Factors. ( 30893239 )
2019
49
The Effect of the Level of Training of the First Assistant on the Outcomes of Adolescent Idiopathic Scoliosis Surgery. ( 30893240 )
2019
50
A hierarchical classification of adolescent idiopathic scoliosis: Identifying the distinguishing features in 3D spinal deformities. ( 30893327 )
2019
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Variations for Idiopathic Scoliosis

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ClinVar genetic disease variations for Idiopathic Scoliosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CELSR2 NM_001408.2(CELSR2): c.6859G> A (p.Val2287Ile) single nucleotide variant Uncertain significance rs141489111 GRCh37 Chromosome 1, 109812092: 109812092
2 CELSR2 NM_001408.2(CELSR2): c.6859G> A (p.Val2287Ile) single nucleotide variant Uncertain significance rs141489111 GRCh38 Chromosome 1, 109269470: 109269470
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Expression for Idiopathic Scoliosis

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Search GEO for disease gene expression data for Idiopathic Scoliosis.
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Pathways for Idiopathic Scoliosis

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Pathways related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 67
Show member pathways
 11.58 ACAN COL1A2 FBN1 MATN1
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GO Terms for Idiopathic Scoliosis

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Cellular components related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.26 ACAN COL1A2 FBN1 MATN1
2 collagen-containing extracellular matrix GO:0062023 8.92 ACAN COL1A2 FBN1 MATN1

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 camera-type eye development GO:0043010 9.33 CHD7 FBN1 MTNR1B
2 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.26 CALM1 CHD7
3 extracellular matrix organization GO:0030198 9.26 ACAN COL1A2 FBN1 MATN1
4 skeletal system development GO:0001501 9.02 ACAN CHD7 COL1A2 FBN1 PAX1

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.55 ACAN CALM1 CELSR2 FBN1 MATN1
2 melatonin receptor activity GO:0008502 8.96 MTNR1A MTNR1B
3 extracellular matrix structural constituent GO:0005201 8.92 ACAN COL1A2 FBN1 MATN1
Sources

Sources for Idiopathic Scoliosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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