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MCID: IDP070
MIFTS: 42

Idiopathic Scoliosis

Categories: Bone diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Idiopathic Scoliosis

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MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 6 15
Scoliosis Idiopathic 54

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060250
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Summaries for Idiopathic Scoliosis

About this section
Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to orthostatic intolerance and marfan syndrome. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. The drugs Cyclobenzaprine and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related phenotypes are behavior/neurological and growth/size/body region

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Related Diseases for Idiopathic Scoliosis

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Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 280, show less)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 29.7 FBN2 FBN1 COL1A2
2 marfan syndrome 29.5 FBN2 FBN1 COL1A2
3 ehlers-danlos syndrome 29.3 FBN2 FBN1 COL1A2
4 distal arthrogryposis 29.1 LBX1 FBN2 FBN1 ADGRG6
5 scoliosis 27.4 VANGL1 SNTG1 POC5 PAX1 MTNR1B MATN1
6 scoliosis, isolated 1 12.6
7 scoliosis, isolated 3 12.1
8 horizontal gaze palsy with progressive scoliosis 11.6
9 scoliosis, isolated 2 11.5
10 scoliosis, isolated 4 11.5
11 scoliosis, isolated 5 11.5
12 back pain 10.8
13 overgrowth syndrome 10.6
14 syringomyelia, noncommunicating isolated 10.5
15 syringomyelia 10.5
16 chiari malformation 10.5
17 bone mineral density quantitative trait locus 3 10.4
18 spondylolisthesis 10.4
19 body mass index quantitative trait locus 1 10.4
20 pain agnosia 10.4
21 infantile scoliosis 10.4
22 respiratory failure 10.3
23 hand skill, relative 10.3
24 polykaryocytosis inducer 10.3
25 scheuermann disease 10.3
26 degenerative disc disease 10.3
27 virus-associated trichodysplasia spinulosa 10.3
28 spinal disease 10.3
29 pneumothorax 10.3
30 47,xyy 10.3
31 spinal cord injury 10.3
32 myopathy 10.2
33 48,xyyy 10.2
34 scleredema adultorum 10.2 MATN1 FBN1
35 chiari malformation type ii 10.2
36 rickets 10.2
37 spondylolysis 10.2
38 neuromuscular disease 10.2
39 ileus 10.2
40 hypermobile ehlers-danlos syndrome 10.2
41 chronic pain 10.2
42 osteoporosis 10.1
43 pectus excavatum 10.1
44 bone mineral density quantitative trait locus 8 10.1
45 bone mineral density quantitative trait locus 15 10.1
46 leukemia, acute lymphoblastic 3 10.1
47 bone resorption disease 10.1
48 constipation 10.1
49 pathologic nystagmus 10.1
50 pik3ca-related overgrowth syndrome 10.1
51 scleroderma, familial progressive 10.1 FBN1 COL1A2
52 lipomatosis, multiple 10.1
53 thrombophilia due to thrombin defect 10.1
54 seizures, scoliosis, and macrocephaly/microcephaly syndrome 10.1
55 bone disease 10.1
56 pleomorphic lipoma 10.1
57 exostosis 10.1
58 superior mesenteric artery syndrome 10.1
59 radiculopathy 10.1
60 poliomyelitis 10.1
61 spinal stenosis 10.1
62 lung disease 10.1
63 neurofibromatosis 10.1
64 pulmonary embolism 10.1
65 muscular dystrophy 10.1
66 plagiocephaly 10.1
67 chiari malformation type i 10.0
68 neural tube defects 10.0
69 diastematomyelia 10.0
70 arts syndrome 10.0
71 muscular dystrophy, duchenne type 10.0
72 anorexia nervosa 10.0
73 pulmonary hypertension 10.0
74 spina bifida occulta 10.0
75 acute cystitis 10.0
76 gangliocytoma 10.0
77 acute kidney failure 10.0
78 ganglioneuroma 10.0
79 dystonia 10.0
80 paraplegia 10.0
81 malignant hyperthermia 10.0
82 eating disorder 10.0
83 trichorhinophalangeal syndrome 10.0
84 hydromyelia 10.0
85 aortic aneurysm, familial thoracic 2 10.0 FBN2 FBN1
86 tricuspid valve prolapse 10.0 FBN2 FBN1
87 arthrogryposis, distal, type 4 10.0 LBX1 FBN2
88 marden-walker syndrome 10.0 FBN2 FBN1
89 postural orthostatic tachycardia syndrome 9.9 FBN2 FBN1
90 attention deficit-hyperactivity disorder 9.9
91 silver-russell syndrome 1 9.9
92 schizophrenia 9.9
93 spinal arachnoiditis 9.9
94 charge syndrome 9.9
95 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
96 body mass index quantitative trait locus 11 9.9
97 body mass index quantitative trait locus 9 9.9
98 body mass index quantitative trait locus 8 9.9
99 body mass index quantitative trait locus 4 9.9
100 body mass index quantitative trait locus 10 9.9
101 body mass index quantitative trait locus 7 9.9
102 body mass index quantitative trait locus 12 9.9
103 body mass index quantitative trait locus 14 9.9
104 body mass index quantitative trait locus 18 9.9
105 alkuraya-kucinskas syndrome 9.9
106 body mass index quantitative trait locus 19 9.9
107 body mass index quantitative trait locus 20 9.9
108 sexual disorder 9.9
109 osteoblastoma 9.9
110 inguinal hernia 9.9
111 disseminated intravascular coagulation 9.9
112 inflammatory spondylopathy 9.9
113 arachnoiditis 9.9
114 personality disorder 9.9
115 heart septal defect 9.9
116 atrial heart septal defect 9.9
117 cerebral palsy 9.9
118 hemopneumothorax 9.9
119 severe acute respiratory syndrome 9.9
120 thoracic outlet syndrome 9.9
121 tricuspid valve insufficiency 9.9
122 pancreatitis 9.9
123 peripheral nervous system disease 9.9
124 spondylitis 9.9
125 mitochondrial myopathy 9.9
126 situs inversus 9.9
127 muscular atrophy 9.9
128 intestinal obstruction 9.9
129 neuropathy 9.9
130 diencephalic syndrome 9.9
131 hypotonia 9.9
132 congenital amyoplasia 9.9
133 thyroid carcinoma 9.9
134 arthrogryposis, distal, type 6 9.9 POC5 FBN2
135 dental fluorosis 9.9 ESR2 COL1A2
136 pelvic organ prolapse 9.9 FBN1 ESR2 COL1A2
137 acromicric dysplasia 9.8 FBN2 FBN1
138 spondyloarthropathy 1 9.8
139 autoimmune disease 9.8
140 candidiasis, familial, 1 9.8
141 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 9.8
142 coloboma of macula 9.8
143 diaphragmatic hernia, congenital 9.8
144 developmental dysplasia of the hip 1 9.8
145 spondyloepiphyseal dysplasia with congenital joint dislocations 9.8
146 endosteal hyperostosis, autosomal dominant 9.8
147 migraine with or without aura 1 9.8
148 motion sickness 9.8
149 neurofibromatosis, type i 9.8
150 strabismus 9.8
151 digeorge syndrome 9.8
152 torticollis 9.8
153 triiodothyronine receptor auxiliary protein 9.8
154 varicose veins 9.8
155 arachnoid cysts, intracranial 9.8
156 celiac disease 1 9.8
157 hemihyperplasia, isolated 9.8
158 osteoporosis, juvenile 9.8
159 insulin-like growth factor i 9.8
160 orofaciodigital syndrome i 9.8
161 ataxia and polyneuropathy, adult-onset 9.8
162 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 9.8
163 short tarsus with absence of lower eyelashes 9.8
164 branchiootic syndrome 1 9.8
165 brittle bone disorder 9.8
166 resting heart rate, variation in 9.8
167 gaze palsy, familial horizontal, with progressive scoliosis 1 9.8
168 bulimia nervosa 9.8
169 major depressive disorder 9.8
170 leukoencephalopathy, arthritis, colitis, and hypogammaglobulinema 9.8
171 cerebellar ataxia, neuropathy, and vestibular areflexia syndrome 9.8
172 bone mineral density quantitative trait locus 17 9.8
173 sacral agenesis with vertebral anomalies 9.8
174 loeys-dietz syndrome 9.8
175 exanthem 9.8
176 autosomal recessive disease 9.8
177 metabolic acidosis 9.8
178 focal dystonia 9.8
179 segmental dystonia 9.8
180 alexithymia 9.8
181 colitis 9.8
182 clostridium difficile colitis 9.8
183 thrombosis 9.8
184 hereditary lymphedema i 9.8
185 osteonecrosis 9.8
186 lactose intolerance 9.8
187 spastic quadriplegia 9.8
188 heart disease 9.8
189 hepatorenal syndrome 9.8
190 clubfoot 9.8
191 synostosis 9.8
192 allergic hypersensitivity disease 9.8
193 oligohydramnios 9.8
194 spinal muscular atrophy 9.8
195 conjugate gaze palsy 9.8
196 quadriplegia 9.8
197 diarrhea 9.8
198 polyneuropathy 9.8
199 amenorrhea 9.8
200 generalized anxiety disorder 9.8
201 reye syndrome 9.8
202 hypothyroidism 9.8
203 avoidant personality disorder 9.8
204 mental depression 9.8
205 ventricular septal defect 9.8
206 dysostosis 9.8
207 enthesopathy 9.8
208 hyperostosis 9.8
209 dental caries 9.8
210 spondylosis 9.8
211 ankylosis 9.8
212 hemangioma 9.8
213 dermatitis 9.8
214 hemoglobinopathy 9.8
215 acute pancreatitis 9.8
216 inner ear disease 9.8
217 glioblastoma multiforme 9.8
218 astrocytoma 9.8
219 gingivitis 9.8
220 germinoma 9.8
221 teratoma 9.8
222 mood disorder 9.8
223 duodenal obstruction 9.8
224 aortic aneurysm 9.8
225 lactic acidosis 9.8
226 skin disease 9.8
227 myofascial pain syndrome 9.8
228 tinea capitis 9.8
229 movement disease 9.8
230 benign ependymoma 9.8
231 neurotic disorder 9.8
232 liver cirrhosis 9.8
233 ovarian cyst 9.8
234 infertility 9.8
235 cellular ependymoma 9.8
236 connective tissue disease 9.8
237 b-cell lymphoma 9.8
238 osteochondrosis 9.8
239 appendicitis 9.8
240 osteoarthritis 9.8
241 nervous system disease 9.8
242 subacute delirium 9.8
243 dermatophytosis 9.8
244 narcolepsy 9.8
245 mechanical strabismus 9.8
246 primary ciliary dyskinesia 9.8
247 neurofibroma 9.8
248 alopecia 9.8
249 hypoglycemia 9.8
250 limb-girdle muscular dystrophy 9.8
251 chromosomal triplication 9.8
252 cytokine deficiency 9.8
253 lymphangiomatosis 9.8
254 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 9.8
255 multicore disease 9.8
256 persistent genital arousal disorder 9.8
257 pineocytoma 9.8
258 pituitary stalk interruption syndrome 9.8
259 polymyositis 9.8
260 precocious puberty 9.8
261 skeletal dysplasias 9.8
262 slipped capital femoral epiphysis 9.8
263 raynaud phenomenon 9.8
264 depression 9.8
265 aneurysm 9.8
266 dysphagia 9.8
267 encephalopathy 9.8
268 foot drop 9.8
269 head injury 9.8
270 headache 9.8
271 syringohydromyelia 9.8
272 thoracic malformation 9.8
273 rapidly involuting congenital hemangioma 9.8
274 inflammatory myopathy with abundant macrophages 9.8
275 ciliopathy 9.8
276 isolated ectopia lentis 9.7 FBN2 FBN1
277 endometriosis of ovary 9.7 ESR2 CHL1-AS2
278 stiff skin syndrome 9.7 FBN2 FBN1 COL1A2
279 arthrogryposis, distal, type 3 9.6 LBX1 FBN2
280 bone structure disease 8.6 PAX1 MTNR1B MATN1 LBX1 FBN2 FBN1

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:



Diseases related to Idiopathic Scoliosis
Sources

Symptoms & Phenotypes for Idiopathic Scoliosis

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MGI Mouse Phenotypes related to Idiopathic Scoliosis:

45 (showing 8, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 ADGRG6 BNC2 CELSR2 CHD7 COL1A2 ESR2
2 growth/size/body region MP:0005378 10.11 ADGRG6 BNC2 CELSR2 CHD7 COL1A2 ESR2
3 cardiovascular system MP:0005385 10.06 ADGRG6 CHD7 COL1A2 ESR2 FBN1 FBN2
4 limbs/digits/tail MP:0005371 9.92 CHD7 COL1A2 ESR2 FBN1 FBN2 LBX1
5 muscle MP:0005369 9.86 ADGRG6 CHD7 COL1A2 ESR2 FBN1 FBN2
6 nervous system MP:0003631 9.85 ADGRG6 CELSR2 CHD7 COL1A2 ESR2 FBN1
7 reproductive system MP:0005389 9.56 CELSR2 CHD7 ESR2 FBN1 FBN2 PAX1
8 skeleton MP:0005390 9.32 ADGRG6 BNC2 CHD7 COL1A2 ESR2 FBN1
Sources

Drugs & Therapeutics for Idiopathic Scoliosis

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Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 121, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclobenzaprine Approved Phase 4 303-53-7 2895
2
Thrombin Approved, Investigational Phase 4
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Tranexamic Acid Approved Phase 4 1197-18-8 5526
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
7
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
8
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
9
Cefazolin Approved Phase 4 25953-19-9 656510 33255
10
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
11 Acetaminophen, hydrocodone drug combination Phase 4
12 Anesthetics, Intravenous Phase 4
13 Excitatory Amino Acid Antagonists Phase 4
14 Anesthetics, Dissociative Phase 4
15 Analgesics Phase 4
16 Anesthetics, General Phase 4
17 Neurotransmitter Agents Phase 4
18 Hemostatics Phase 4
19 Antifibrinolytic Agents Phase 4
20 Coagulants Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Analgesics, Opioid Phase 4
23 Hormones Phase 4
24 Calcium, Dietary Phase 4
25 Psychotropic Drugs Phase 4
26 Anti-Anxiety Agents Phase 4
27 Anticonvulsants Phase 4
28 Narcotics Phase 4
29 calcium channel blockers Phase 4
30 Anti-Bacterial Agents Phase 4
31 Dialysis Solutions Phase 4
32 Anti-Infective Agents Phase 4
33 abobotulinumtoxinA Phase 4
34 Cholinergic Agents Phase 4
35 Botulinum Toxins Phase 4
36 Botulinum Toxins, Type A Phase 4
37
Calcium Nutraceutical Phase 4 7440-70-2 271
38
Calcium carbonate Approved, Investigational Phase 3 471-34-1
39
Clevidipine Approved, Investigational Phase 2, Phase 3 167221-71-8
40
Morphine Approved, Investigational Phase 3 57-27-2 5288826
41
Methadone Approved Phase 3 76-99-3 4095
42
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
43
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
44 Gastrointestinal Agents Phase 3
45 Antacids Phase 3
46 Anti-Ulcer Agents Phase 3
47 Respiratory System Agents Phase 3
48 Antitussive Agents Phase 3
49 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
50 Anesthetics Phase 3
51 Anesthetics, Local Phase 3
52 Pharmaceutical Solutions Phase 3
53 Sodium Channel Blockers Phase 3
54 Anti-Arrhythmia Agents Phase 3
55 Diuretics, Potassium Sparing Phase 3
56
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
57
Ketorolac Approved Phase 2 66635-83-4, 74103-06-3 3826
58
Acetaminophen Approved Phase 2 103-90-2 1983
59
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2 7487-88-9 24083
60
Remifentanil Approved Phase 2 132875-61-7 60815
61
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
62
Meperidine Approved Phase 2 57-42-1 4058
63
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
64
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
65
Fibrinolysin Investigational Phase 2 9004-09-5
66 Opiate Alkaloids Phase 2
67 Tocolytic Agents Phase 2
68 Cyclooxygenase Inhibitors Phase 2
69 Antipyretics Phase 2
70 Antirheumatic Agents Phase 2
71 Anti-Inflammatory Agents Phase 2
72 Anti-Inflammatory Agents, Non-Steroidal Phase 2
73 Tissue Plasminogen Activator Phase 2
74 Plasminogen Phase 2
75 lysine Phase 2
76
Metformin Approved Phase 1 657-24-9 14219 4091
77 Serine Proteinase Inhibitors Phase 1
78
protease inhibitors Phase 1
79 HIV Protease Inhibitors Phase 1
80 Trypsin Inhibitors Phase 1
81
Serine Investigational, Nutraceutical Phase 1 56-45-1 5951
82
Cobalt Approved, Experimental 7440-48-4 104729
83
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
84
Ibuprofen Approved 15687-27-1 3672
85
Desflurane Approved 57041-67-5 42113
86
Methylcobalamin Approved, Investigational 13422-55-4
87
leucovorin Approved 58-05-9 6006 143
88
Hydroxocobalamin Approved 13422-51-0 15589840 11953898
89
Iron Approved, Experimental 15438-31-0, 7439-89-6 27284 23925
90
Ropivacaine Approved 84057-95-4 71273 175805
91
tannic acid Approved 1401-55-4
92
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
93
Calcifediol Approved, Nutraceutical 19356-17-3 5283731 6433735
94
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
95
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
96
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
97
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
98
Cobalamin Experimental 13408-78-1 6857388
99 Deamino Arginine Vasopressin
100 Vasopressins
101 Arginine Vasopressin
102 Hydroxycholecalciferols
103 Hypnotics and Sedatives
104 Anesthetics, Inhalation
105 Trace Elements
106 Nutrients
107 Micronutrients
108 Vitamins
109 Calciferol
110 Antioxidants
111 Protective Agents
112 Tin Fluorides
113 Epoetin alfa 113427-24-0
114 Vitamin B Complex
115 Vitamin B 12
116 Hematinics
117 Folate
118 Vitamin B9
119 Vitamin B12
120
Terephthalic acid 100-21-0 7489
121
Arginine Investigational, Nutraceutical 74-79-3 6322

Interventional clinical trials:

(showing 178, show less)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Unknown status NCT02651324 Phase 4 Ketamine
2 Effectiveness Of Gelatin Matrix With Human Derived Thrombin On Blood Loss, Surgical Time, Hospital Stay And Complications In Adolescents Undergoing Spine Surgery For Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial. Unknown status NCT01451788 Phase 4
3 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
4 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
5 Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents Completed NCT01325493 Phase 4 Ketamine;Normal Saline
6 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
7 The Effects of Fibrinogen Concentrate Infusion on Perioperative Blood Loss and Allogeneic Blood Conservation in Patients Undergoing Scoliosis Surgery Completed NCT03183479 Phase 4 Fibrinogen Concentrate Human;Normal saline
8 Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction Completed NCT01977937 Phase 4 Gabapentin 250mg/5mL NDC:59762-5025-01;Simple Syrup
9 A Prospective, Randomized, Double-blinded Single-site Control Study Comparing Blood Loss Prevention of Tranexamic Acid (TXA) to Epsilon Aminocaproic Acid (EACA) for Corrective Spinal Surgery Completed NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
10 Intravenous Lidocaine to Reduce Postoperative Opioid Consumption and Improve Recovery After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Recruiting NCT03893318 Phase 4 IV lidocaine;Placebos
11 Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery. Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
12 Skeletal Muscle and Adipose Tissue Concentrations of Cefazolin Comparing Two Different Dosing Regimens During Pediatric Posterior Spinal Fusion Surgery Active, not recruiting NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
13 Dysport ® (abobotulinumtoxinA) as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis Not yet recruiting NCT03935295 Phase 4 AbobotulinumtoxinA;Placebos
14 Perioperative Outcomes of Multilevel Posterior Spinal Fusion in Adolescent Scoliosis With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
15 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Withdrawn NCT00768313 Phase 4
16 Can Calcium and Vitamin D Supplementation Improve Bone Mineral Density and Curve Progression in Girls With Adolescent Idiopathic Scoliosis? Completed NCT01103115 Phase 3
17 Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial Completed NCT01108211 Phase 3
18 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
19 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
20 Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children. Completed NCT00323752 Phase 3
21 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Recruiting NCT02558010 Phase 3 Methadone;Morphine
22 Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children Not yet recruiting NCT04069169 Phase 3 Lidocaine;Saline Solution
23 The Use of Perioperative Gabapentin in Adolescents Undergoing Posterior Spinal Fusion for Idiopathic Scoliosis to Prevent Chronic Postsurgical Pain, a Pilot Study. Suspended NCT03867240 Phase 3 Gabapentin
24 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
25 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
26 The Efficacy of Intravenous Tranexamic Acid in Decreasing Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
27 Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
28 Analgesia Following Posterior Spinal Fusion: Methadone vs Magnesium Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
29 Ultrasound Guided Erector Spinae Plane Block in Scoliotic Adolescents Undergoing Posterior Spine Instrumentation . A Randomized Controlled Trial Completed NCT03968146 Phase 2 Fentanyl;additional Fentanyl;Morphine;rescue Morphine;pethidine;Ketorolac;Acetaminophen
30 Blood Loss and Transfusion Requirement in Pediatric Patients With Non-Idiopathic Scoliosis Treated With Tranexamic Acid Undergoing Posterior Spinal Instrumentation and Fusion. Terminated NCT01089140 Phase 2 Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
31 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics During Static and Dynamic Activities in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
32 An Innovative Body-Mapping Tank Top Equipped With Biofeedback System for Adolescents With Early Scoliosis Completed NCT02471508 Phase 1
33 Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery Completed NCT00357851 Phase 1 Aprotinin
34 Treatment of Adolescent Idiopathic Scoliosis Patients Using the Ellipse MAGEC System Unknown status NCT01633931
35 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245
36 Application Research of Physiotherapeutic Scoliosis Specific Exercises in Adolescent Idiopathic Scoliosis Unknown status NCT02968043
37 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
38 Development of Exercise Protocol for Scoliosis Using Surface Electromyography(S-EMG) Unknown status NCT03675984
39 Effect of the Severity and the Treatment (Orthosis Versus Surgery)of the Idiopathic Scoliosis on the Locomotor Mechanism of the Gait. Unknown status NCT00842218
40 A Randomized Controlled Trial: Comparison of a Top Loading MESA® Spinal System With MESA Railâ„¢ and a Side Locking Pedicle Screw System for the Treatment of Adolescent Paediatric Spine Deformity Unknown status NCT02590380
41 The Effect of Asymmetric Spinal Stabilization Exercise on Scoliosis Unknown status NCT03497520
42 Efficacy and Safety of Desmopressin Combined With Tranexamic Acid on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
43 A New Spinal Brace Design Concept for the Treatment of Adolescent Idiopathic Scoliosis Unknown status NCT03365804
44 Scoliosis-Specific Exercises for At-Risk Mild Adolescent Idiopathic Scoliosis Curves: A Multi-Site Preliminary Randomized Trial Unknown status NCT02807545
45 Idiopathic Scoliosis Treated by Posterior Spinal Instrumentation. Evaluation of the 3D Correction, Aesthetic Outcomes and Quality of Life. Completed NCT01019109
46 Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Completed NCT03539770
47 Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients Completed NCT03820895
48 Idiopathic Scoliosis Surgery in Adolescents ; Earnings a Multidisciplinary Management of Pain and Quality of Life Completed NCT02890654
49 Five Days of Intensive Postoperative Rehabilitation is Superior Than Mobilization in Improving Length of Hospitalization and Outcome of Patients Having Scoliosis Surgery: A Randomized Controlled Trial Completed NCT04403152
50 Effect of Conservative Treatment on Pulmonary Functions, Gait Oxygen Consumption Balance and Lower Limb Load Distribution in Adolescents With Idiopathic Scoliosis Completed NCT03514082
51 Evaluation of an Anesthetic Optimization Technique in Adolescent Idiopathic Scoliosis Surgery Completed NCT02481570
52 The Effect of Core Stabilization Training on Respiratory Parameters, Peripheral Muscle Strength, Balance, Functional Capacity and Quality of Life in Children With Adolescent Idiopathic Scoliosis Completed NCT03823053
53 The Effect of the Inspiratory Muscle Training on Respiratory Muscle Strength, Respiratory Function and Functional Capacity in Adolescents With Idiopathic Scoliosis Completed NCT03391895
54 Motion Preservation Evaluation Below Fusions of the Spine in Adolescent Idiopathic Scoliosis Completed NCT01661998
55 A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace Completed NCT01336114
56 Single-blind Comprehensive Cohort Study Incorporating a Randomized Controlled Design on Bracing in AIS: A Feasibility Study Completed NCT00989495
57 Prospective Study: Long-Term Pulmonary Function, Health-Related Quality of Life, and Sagittal Plane Alignment Following the Treatment of Pediatric Scoliosis Completed NCT01760434
58 Short-term Effects of the Simultaneous Use of Two Physiotherapeutic Methods in the Treatment of Adolescent Idiopathic Scoliosis - Pilot Study Completed NCT01250860
59 Functional Testing, and Biomechanics Before and After Scoliosis Surgery Completed NCT02237248
60 Effects of Home Exercise Intervention on Bone Density, Muscle Functions, Quality of Life, and Curve Progression in Girls With Adolescent Idiopathic Scoliosis Completed NCT03157570
61 Prediction of 3D Effect of Brace in Adolescent and Children Idiopathic Scoliosis Treatment Using EOS Imaging System and "Anatomic Transfer". Completed NCT03209752
62 Evaluation of Adam's Forward Bend Test and Smartphone Application in Screening of Adolescent Idiopathic Scoliosis Completed NCT04092335
63 Impact of Aerobic Training and Combined in Inflammatory Markers in Patients With Adolescent Idiopathic Scoliosis Completed NCT02413788
64 Ghrelin Cellular Resistance Study in Adolescents With Idiopathic Scoliosis Completed NCT02829476
65 Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA) Completed NCT02302534
66 Impact of Metal Density on Deformity Correction in Posterior Fusions for Adolescent Idiopathic Scoliosis Completed NCT04175145
67 Results of an Aerobic Exercising Program on Respiratory Muscle Strength in Patients With Adolescent Idiopathic Scoliosis: a Randomized, Controlled Trial Completed NCT00886652
68 Gait and Postural Stability Assessment in Children With Idiopathic Scoliosis Undergoing Posterior Spine Instrumentation Completed NCT01109082
69 Comparison of Dynamic Radiographs in Determining Fusion Level in Adolescent Idiopathic Scoliosis Correction Completed NCT03296228
70 Core Stabilization Exercise Versus Scientific Exercises Approach to Scoliosis in the Treatment of Adolescent Idiopathic Scoliosis: A Randomized Single Blind Trial Completed NCT02978820
71 Prevalence of Psychiatric Disorders in Adolescents With Idiopathic Scoliosis: A Pilot Study of a Validated Screening Tool Completed NCT00445393
72 THE ASSESSMENT OF QUALITY OF LIFE AND FUNCTION OF ADULTS TREATED IN ADOLESCENCE FOR IDIOPATHIC SCOLIOSIS WITH PHYSICAL EXERCISES Completed NCT01384955
73 End-growth Results of Tailored Treatment in 1938 Adolescents With High Risk Idiopathic Scoliosis: a Cohort Study From a Prospective Clinical Database Completed NCT03843216
74 Prospective Trial to Evaluate Initial Safety of the HemiBridgeâ„¢ System in Guided Spinal Growth Treatment of Progressive Idiopathic Scoliosis Completed NCT01465295
75 The Effectiveness of Two Different Exercises in Adolescent Idiopathic Scoliosis: A Single-blind Study Completed NCT04421157
76 Effect of Physiotherapeutic Scoliosis-Specific Exercises on Spine Joint Reposition Sensation in Adolescent Idiopathic Scoliosis Completed NCT04215497
77 Effectiveness of Spinal Stabilization Exercises for Low Back Pain in Adolescents With Idiopathic Scoliosis Completed NCT01550497
78 Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients: Volatile Agents Versus Total Intravenous Anesthesia Completed NCT01549873 propofol;Desflurane
79 Internet-administered Adolescent Scoliosis Questionnaires Compared With Traditional Pencil and Paper Versions: a Randomized Crossover Design Completed NCT01772459
80 The Effect of Anesthesia on the Recruitment of Motor Evoked Potentials Using an Increased Number of Pulses Completed NCT02199314 Desflurane
81 Ergonomic Brace Wear for Adolescent Idiopathic Scoliosis Completed NCT03617120
82 Back Pain Management With Spinal Manipulation Therapy Compared to Usual Medical Care in Adolescent Idiopathic Scoliosis Patients: A Pilot Study Completed NCT02609009
83 Pedicle Screw Usage in Conventional Fixation Pattern Constructs Compared to Thoracic Hook Constructs in Adolescent Idiopathic Scoliosis Patients and Neuromuscular Ambulators Completed NCT01581021
84 Screening and Prevalence of Adolescent Idiopathic Scoliosis in Selected Urban and Countryside Schools in Egypt Completed NCT03894865
85 Investigation of the Effects of Spinal Stabilization and Body Awareness Exercises on Subjective Vertical Perception, Curve Magnitude, Body Symmetry and Quality of Life in Adolescent Idiopathic Scoliosis Completed NCT02552615
86 Genetic Evaluation for the Scoliosis Gene(s) in Patients With Neurofibromatosis 1 and Scoliosis Completed NCT01776125
87 Determine the Optimum Applied Pressure for the Brace Treatment of Scoliosis Completed NCT02996643 Early Phase 1
88 Safety and Effectiveness Evaluation of the Minimal Invasive Deformity Correction (MID-C) System in Adolescent Idiopathic Scoliosis (AIS) Completed NCT03071471
89 Safety and Effectiveness Evaluation of the Minimal Invasive Deformity Correction (MID-C) System in Adolescent Idiopathic Scoliosis (AIS) Completed NCT03071445
90 Patients' Arm Positioning in the EOS® Stereoradiography System: Study the Sagittal Spinal Parameters and Postural Balance in EOS® Full Spine X-rays in Scoliosis Completed NCT02269657
91 Multi-center Project: Spinal Abnormalities in Neurofibromatosis Type1 (NF1) Patients Completed NCT00667836
92 The Investigation of HDAC and NF Kappa B Activity in Peripheral Skeletal Muscle in COPD Completed NCT00180752
93 Perioperative Use of Gabapentin To Decrease Opioid Requirements in Pediatric Spinal Fusion Patients Completed NCT00726999 Gabapentin;Placebo;Morphine
94 Efficacy of Peak Scoliosis Brace in Pain Management For Adult Scoliosis Patients Completed NCT02643290
95 Changes in Cerebral Oxygenation During the Administration of Cell Saver Blood and Allogeneic Blood Completed NCT02607150
96 Validation of Triggered EMG Values for Pedicle Screws Using a Powered Screwdriver Completed NCT02064101
97 A Pilot Study of the Effectiveness of Complementary Therapies to Reduce Pain in Spinal Fusion Patients Completed NCT02409615
98 Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and Clubfeet Completed NCT02755766
99 Autologous Blood Transfusion Technique in Idiopathic Scoliosis Surgery - a Comparison Between Intraoperative Cell Salvage With Hemodilution Techniques Versus Cell Salvage Technique Alone Completed NCT02112409
100 Effect of Compliance Counseling on Brace Success in Patients With Idiopathic Scoliosis Completed NCT02412137 Early Phase 1
101 The Treatment of Progressive Early Onset Spinal Deformities: A Multi-Center Outcome Study Completed NCT02299362
102 A Six Years Longitudinal Cohort Study on the Changes in Bone Density, Bone Quality and Its Association With Bone Turnover Markers and Curve Severity in Adolescent Idiopathic Scoliosis With and Without 2 Years of Calcium and Vit-D Supplementation Completed NCT02904421
103 Impact of the Choice of the Distal Vertebral When Posterior Instrumentation in the Surgery of the Thoracic Adolescent Idiopathic Scoliosis Completed NCT02791776
104 The Effect of Flexible Thoracolumbar Brace on Idiopathic Scoliosis, Prospective, Randomized, Open-label Trial Recruiting NCT03676712
105 Repeatability and Reproducibility of Low-dose Digital Radiographs in the Idiopathic Scoliosis Recruiting NCT03464318
106 Safety and Feasibility of a Vertebral Body Tethering Technique for Pediatric Idiopathic Scoliosis Recruiting NCT03802656
107 Curve Progression in Children and Adolescent Idiopathic Scoliosis With and Without Sleep-disordered Breathing Recruiting NCT03858244
108 Comparison of the Effects of Controlled Schroth Exercise and Home Programs on Body Symmetry, Deformity Perception and Quality of Life in Adolescent Idiopathic Scoliosis Recruiting NCT04203394
109 Efficacy of Three-dimensionally Integrated Exercise for Scoliosis in Patients With Adolescent Idiopathic Scoliosis Recruiting NCT03427970
110 Evaluation of Pain Following Scoliosis Surgery.- RACHIDOL Recruiting NCT03686371
111 Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis Recruiting NCT02315729
112 Post-approval Registry Study to Evaluate the Continued Safety and Probable Benefit of the MID-C System for 5 Years Post-Implantation in Adolescent Idiopathic Scoliosis (AIS) Recruiting NCT04296903
113 Return to Sport After Posterior Spinal Fusion in Adolescent Athletes With Idiopathic Scoliosis: a Prospective Study Recruiting NCT03513120
114 Investigation of The Effects of Scoliosis Specific Exercises Before Adolescent Idiopathic Scoliosis Surgery Recruiting NCT04357561
115 Experimental Evaluation of Back Braces for the Treatment of Spinal Deformity Produced With 3D Printing Technology Recruiting NCT04282408
116 Green Sun Medical Dynamic Scoliosis Brace Recruiting NCT03641469
117 Your Scoliosis Journey: A Survey for Patients Treated for Scoliosis and Their Families Recruiting NCT03017755
118 Non Fusion Surgery in Adolescent Idiopathic Scoliosis Patients Using the Nemost-AIS System Recruiting NCT04441411
119 Establishment of a Gold Standard Formula for Blood Loss Calculation in Adolescent Idiopathic Scoliosis (AIS) Surgery Recruiting NCT03990376
120 Pilot Study for a Randomized Controlled Clinical Trial on the Effect of Global Postural Re-education in the Treatment of Idiopathic Scoliosis: a Feasibility Study Recruiting NCT03663088
121 Safety and Efficacy of a Vertebral Body Tethering Technique for Pediatric Idiopathic Scoliosis Recruiting NCT04119284
122 Predictive Progressive Factors of Adolescent Idiopathic Scoliosis Recruiting NCT02862392
123 Slicer+PLUS: Collaborative, Open-source Software for Ultrasound Analysis Recruiting NCT03222739
124 Preventing Curve Progression and the Need for Bracing in Early Diagnosed Adolescent Idiopathic Scoliosis Using Calcium Plus Vitamin D Supplementation - A Randomized Double-blinded Placebo-controlled Trial Recruiting NCT03533010
125 SIMDiscovery: The Benefits of Utilizing a Preparation Program With Simulation in Reducing Anxiety and Increasing Preparedness Among Parents and Their Children Undergoing Spinal Fusion Surgery Recruiting NCT03835390
126 CLOSED SUCTION DRAIN VS. NO DRAIN IN ADOLESCENTS UNDERGOING PEDICLE SCREW INSTRUMENTATION FOR IDIOPATHIC SCOLIOSIS (DAISY 2018). A Randomized Clinical Trial Recruiting NCT03729947
127 Biopsychosocial Model for a Multidisciplinary Perioperative Care Pathway in Patients Undergoing Posterior Spinal Fusion Surgery for Adolescent Idiopathic Scoliosis Recruiting NCT04038229
128 Evaluation of Health-related Quality of Life (HRQoL) of Adolescent Idiopathic Scoliosis (AIS) Patients Who Require Bracing or Surgery Using SRS-22 Questionnaire Recruiting NCT03915106
129 Development of a New Simplified Thumb Ossification Composite Index (TOCI) and Its Application to Predict Skeletal Maturity and Curve Progression in Idiopathic Scoliosis and Normal Subjects Recruiting NCT03904914
130 Determining the Best Indications for Initiating Brace Treatment for Adolescent Idiopathic Scoliosis Recruiting NCT04117334
131 Peri-operative Pain Assessment in Children Undergoing Orthopaedic Surgery Recruiting NCT04244760
132 Clinical Assessment of a Motorized Spinal Distraction Rod in the Severe to Early Scoliosis Child Recruiting NCT03330158
133 Effects of Real-Time Feedback Assisted Self-Correction on the Posture of Scoliotic Patients: A Prospective, Monocentric, Randomized With Stratification on the Type of Scoliosis, Comparative and Open-label Study Recruiting NCT03978273
134 Evaluating the Effectiveness of Posture Correction Girdle for Adolescents With Early Scoliosis Recruiting NCT03929042
135 A New Spinal Orthosis With an Integrated System of Electric Surface Stimulation and Heat Sensing for Adolescent Idiopathic Scoliosis Recruiting NCT03825159
136 Brace Weaning Protocol: A Randomized Controlled Trial Alongside Cost-effectiveness Analysis Comparing Gradual and Immediate Weaning Recruiting NCT03329716
137 Effect of Feedback and Monitoring on Patient Compliance With Spinal Orthoses for Scoliosis Treatment Recruiting NCT03292601
138 Ultrasound Guided Bilateral Retrolaminar Block as Analgesia for Adolescent Idiopathic Scoliosis Correction Recruiting NCT04336111
139 Ultrasound Guided Bilateral Erector Spinae Block as Analgesia for Adolescent Idiopathic Scoliosis Correction Recruiting NCT04336046 normal saline;Bupivacaine
140 Effect of Ultra-short-term Treatment of Patients With Iron Deficiency or Anemia Undergoing Adolescent Scoliosis Correction Recruiting NCT04343170 Placebo;ferric carboxymaltose , α erythropoietin, vitamin B12, oral folic acid
141 Development and Validation of the MOBI Questionnaire Recruiting NCT03929614
142 Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis Recruiting NCT02434003
143 Safety and Feasibility of a Vertebral Body Tethering Technique for Pediatric Idiopathic Scoliosis Active, not recruiting NCT03194568
144 Multicenter Study on the Contribution of Surgical Treatment by ST2R Technique (Simultaneous Translation on Two Rods) in Scoliosis of the Children and Adolescents Active, not recruiting NCT02820012
145 CONTRAIS: CONservative TReatment for Adolescent Idiopathic Scoliosis. A Randomised Controlled Trial Active, not recruiting NCT01761305
146 Use of Ultrasonic Bone Scalpel in Adolescent Idiopathic Scoliosis - Randomized Clinical Trial Active, not recruiting NCT02781324
147 A Randomized Clinical Trial of Brace Treatment Active, not recruiting NCT03022656
148 Three-dimensional Effects of Bracing in Adolescent Idiopathic Scoliosis Active, not recruiting NCT03298256
149 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Active, not recruiting NCT02285621
150 Effect of Physiotherapeutic Scoliosis Specific Exercises on Plantar Pressure Distribution and Balance in Adolescent Idiopathic Scoliosis Active, not recruiting NCT04226209
151 Assesment of Enhanced Recovery After Pediatric Idiopathic Scoliosis Surgery Active, not recruiting NCT04012528
152 Retrospective Review With Prospective Surveillance of Safety and Efficacy in a Clinical Series of Spinal Tethering Patients Active, not recruiting NCT02897453
153 Efficacy of Scoliosis Specific Exercise (SSE) in Patients With Adolescent Idiopathic Scoliosis (AIS) During Bracing: A Randomized Controlled Clinical Trial Active, not recruiting NCT03305185
154 A Multicenter Randomized Controlled Trial to Compare the Effect of Schroth Exercises to Standard Care on Curve Characteristics, Posture, and Quality Of Life in Adolescents With Idiopathic Scoliosis Active, not recruiting NCT01610908
155 Coping After Pediatric Scoliosis Surgery: How Does it Affect Pain and Function? Enrolling by invitation NCT04063670
156 Preservation of Thoracic Kyphosis and Coronal Curve Correction as a Function of Rod Stiffness in the Surgical Treatment of Adolescent Idiopathic Scoliosis With the Use of the K2M MESA Railâ„¢ Deformity System Enrolling by invitation NCT02062606
157 Scoliosis Outcomes Database Registry Enrolling by invitation NCT01661959
158 Anisotropic Textile Braces for Adolescent Idiopathic Scoliosis Enrolling by invitation NCT03332251
159 Safety and Efficacy of Anisotropic Textile Braces for Adolescent Idiopathic Scoliosis Enrolling by invitation NCT02589106
160 A Randomized Controlled Trial of Virtual Reality for Pain Management in the Post-Operative Period Following Orthopedic Surgery Enrolling by invitation NCT03584776
161 Safety and Efficacy of Functional Intimate Apparel for Adolescents With Early Scoliosis Enrolling by invitation NCT02271256
162 Physical Activity, Motor Competence, Pulmonary Function, and Quality of Life in Children With Severe Spinal Disease Enrolling by invitation NCT03494829
163 Prospective Sensor Controlled Compliance Analysis of Shoulder Abduction Splint After Rotator Cuff Repair Enrolling by invitation NCT03054753
164 Study of Posture Correction Girdle of Adolescents With Early Scoliosis Enrolling by invitation NCT01776736
165 POSTOPERATIVE OPIOID-SPARING EFFECT OF INTRAOPERATIVE PAIN MONITORING USING THE ANALGESIA NOCICEPTIVE INDEX (ANI) DURING IDIOPATHIC SCOLIOSIS CORRECTION IN CHILDREN. Not yet recruiting NCT04047225
166 A Protocol of Accelerated Rehabilitation for Patients Undergoing Adolescent Idiopathic Scoliosis Correction Surgery - An Internal Pilot Study Not yet recruiting NCT03719807
167 Effectiveness of Three Dimensional Correction During in Bracing in Adolescent Idiopathic Scoliosis: a Prospective Randomised Clinical Trial of Rigo Chêneau Versus Boston-style Orthoses Not yet recruiting NCT04382638
168 Design of a Dynamic Pressure Monitoring System for Orthotic Treatment of Scoliosis Not yet recruiting NCT03716843
169 Pediatric Scoliosis Surgery: Enhanced Recovery With Erector Spinae Plane Blockade Utilizing Surgically Placed Catheters Not yet recruiting NCT04153994
170 Trial of Personalized Flexible Bracing Treatment of Adolescents Idiopathic Scoliosis Not yet recruiting NCT04116723
171 The Adult Degenerative Scoliosis Exercise Trial (Pilot Study) Not yet recruiting NCT03862417
172 The Use of TLSOs in the Treatment of Adolescent Idiopathic Scoliosis: A Prospective, Randomized Controlled Study Terminated NCT01370057
173 Single Versus Double Epidural Catheter Technique for Postoperative Analgesia Following Scoliosis Surgery Terminated NCT01900626 epidural catheter
174 Multicenter, Prospective, Partially Randomized, Controlled Trial of Robotic-guided vs. Freehand Corrective Surgery for Pediatric Scoliosis Terminated NCT02084264
175 Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST) Terminated NCT00448448
176 Safety and Effectiveness Evaluation of the Minimal Invasive Deformity Correction (MID-C) System in Adolescent Idiopathic Scoliosis (AIS) Terminated NCT02200302
177 Risk Factors for Psychiatric Disorders Associated With Adolescent Idiopathic Scoliosis Withdrawn NCT00958373
178 The Effectiveness of Clinical Hypnotherapy in Reducing Anxiety and Pain in Major Surgical Procedures (Nuss and Scoliosis Repair) Withdrawn NCT02376634

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Genetic Tests for Idiopathic Scoliosis

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Anatomical Context for Idiopathic Scoliosis

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MalaCards organs/tissues related to Idiopathic Scoliosis:

40
Bone, Testes, Spinal Cord, Lung, Brain, Breast, Skeletal Muscle
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Publications for Idiopathic Scoliosis

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Articles related to Idiopathic Scoliosis:

(showing 7091, show less)
# Title Authors PMID Year
1
Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. 54 61
17632395 2007
2
[Expression of neuronal nitric oxide synthase and inducible nitric oxide synthase in the erector spinal muscles in idiopathic scoliosis]. 54 61
15379275 2004
3
[Expression of calmodulin and nNOS in the paraspinal muscles in idiopathic scoliosis]. 61 54
15387945 2004
4
Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis. 54 61
8982144 1996
5
Feasibility of Proxy-Reported EQ-5D-3L-Y and Its Agreement in Self-reported EQ-5D-3L-Y for Patients With Adolescent Idiopathic Scoliosis. 61
32539293 2020
6
Changes in Cervical Spinal Alignment After Thoracolumbar Corrective Surgery in Adult Patients With Adolescent Idiopathic Scoliosis. 61
32539290 2020
7
Group-based Trajectory Modeling: A Novel Approach to Classifying Discriminative Functional Status Following Adult Spinal Deformity Surgery: Study of a 3-year Follow-up Group. 61
32049931 2020
8
Does spinal fusion influence vestibular information in scoliosis patients? Unstable equilibrium analysis. 61
32467656 2020
9
Correction to: Is Cutibacterium acnes early surgical site infection rate related to the duration of antibiotic prophylaxis in adolescent idiopathic scoliosis surgery? 61
32562078 2020
10
Comparison of Pulmonary Function After Selective Anterior Versus Posterior Fusion for the Correction of Thoracolumbar and Lumbar Adolescent Idiopathic Scoliosis. 61
32435563 2020
11
A Predictive Model of Progression for Adolescent Idiopathic Scoliosis Based on 3D Spine Parameters at First Visit: Erratum. 61
32472905 2020
12
Willingness to enroll in a surgical randomized controlled trial: patient and parent preferences regarding implant density for adolescent idiopathic scoliosis fusion. 61
32495208 2020
13
Associations between three-dimensional measurements of the spinal deformity and preoperative SRS-22 scores in patients undergoing surgery for major thoracic adolescent idiopathic scoliosis. 61
32488765 2020
14
Is it feasible to implement a rapid recovery pathway for adolescent idiopathic scoliosis patients undergoing posterior spinal instrumentation and fusion in a single-payer universal health care system? 61
32488767 2020
15
A Positive (+ve) Postoperative Upper Instrumented Vertebra Tilt Angle (≥0°) Significantly Increases the Risk of Medial Shoulder and Neck Imbalance in Lenke 1 and 2 Adolescent Idiopathic Scoliosis Patients. 61
32032325 2020
16
Letter to the Editor concerning "Safety and effectiveness of minimally invasive scoliosis surgery for adolescent idiopathic scoliosis: a retrospective case series of 84 patients" by Yang JH, et al. (Eur Spine J; [2020] 29:761-769). 61
32519029 2020
17
Correction to: Opioid prescribing practices after posterior spinal arthrodesis for adolescent idiopathic scoliosis. 61
32533546 2020
18
Exome sequencing analysis identifies frequent oligogenic involvement and FLNB variants in adolescent idiopathic scoliosis. 61
32381728 2020
19
What Constitutes Shoulder Imbalance in Adolescent Idiopathic Scoliosis? Aesthetic Threshold for Surgical Correction. 61
32234356 2020
20
Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis. 61
32548139 2020
21
Upregulation of cGMP-dependent Protein Kinase (PRKG1) in the Development of Adolescent Idiopathic Scoliosis. 61
32558266 2020
22
Operative time in adolescent idiopathic scoliosis surgery: a need for a standard definition. 61
32558776 2020
23
Predictors of cost for posterior spinal fusion in adolescent idiopathic scoliosis. 61
32096128 2020
24
Current concepts in the diagnosis and management of adolescent idiopathic scoliosis. 61
32314025 2020
25
Severe persistent coronal imbalance following instrumented posterior spinal fusion for adolescent idiopathic scoliosis. 61
32500442 2020
26
Severe adolescent idiopathic scoliosis: posterior staged correction using a temporary magnetically-controlled growing rod. 61
32506163 2020
27
Does bracing for adolescent idiopathic scoliosis affect operative results? 61
32291582 2020
28
Towards a new 3D classification for adolescent idiopathic scoliosis. 61
32026444 2020
29
Prevalence of adolescent idiopathic scoliosis in Turkey: an epidemiological study. 61
31972303 2020
30
Characterization of progressive changes in pedicle morphometry and neurovascular anatomy during growth in adolescent idiopathic scoliosis versus adolescents without scoliosis. 61
32557264 2020
31
Reliability Comparison between "Distal Radius and Ulna" and "Simplified Tanner-Whitehouse III" Assessments for Patients with Adolescent Idiopathic Scoliosis. 61
31992028 2020
32
Outcomes of pregnancy in operative vs. nonoperative adolescent idiopathic scoliosis patients at mean 30-year follow-up. 61
32578160 2020
33
Comparison of surgical correction rates between titanium and cobalt-chrome-alloy as rod materials in adolescent idiopathic scoliosis. 61
32572073 2020
34
Is daily walking distance affected in adolescent idiopathic scoliosis? An original prospective study using the pedometer on smartphones. 61
32563619 2020
35
Morphological Differences between the Pedicles in Nondystrophic Scoliosis Secondary to Neurofibromatosis Type 1 and Those in Adolescent Idiopathic Scoliosis. 61
32540291 2020
36
Impact of lowest instrumented vertebra tilt and rotation on uninstrumented lumbar curve and L4 tilt in thoracic adolescent idiopathic scoliosis. 61
32534495 2020
37
The Benefits of Sparing Lumbar Motion Segments in Spinal Fusion for Adolescent Idiopathic Scoliosis Are Evident at 10 Years Postoperatively. 61
31923128 2020
38
Incidence of scoliosis among junior high school students in Zhongshan city, Guangdong and the possible importance of decreased miR-30e expression. 61
31885345 2020
39
Analysis of scoliosis deformation in the Zebris computer study as an assessment of the effectiveness of the FED method in the treatment of idiopathic scolioses. 61
32564042 2020
40
Development: How the Reissner Fiber Keeps Our Back Straight. 61
32574632 2020
41
Evaluation of a new apparatus combining a mobile device and hand-held roller for the detection of spinal deformities: association with the sum of the right and left angles of trunk inclination. 61
32524285 2020
42
The FED-Method (Fixation, Elongation, Derotation) - a Machine-supported Treatment Approach to Patients with Idiopathic Scoliosis - Systematic Review. 61
31404938 2020
43
The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis. 61
32109313 2020
44
Relationship between autophagy, apoptosis and endoplasmic reticulum stress induced by melatonin in osteoblasts by septin7 expression. 61
32323792 2020
45
[Chest deformity as a cause of tracheobronchial compression. A pediatric case]. 61
32470279 2020
46
Visual Verticality Perception in Spinal Diseases: A Systematic Review and Meta-Analysis. 61
32503240 2020
47
SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. 61
32386528 2020
48
Quality improvement in post-operative opioid and benzodiazepine regimen in adolescent patients after posterior spinal fusion. 61
31925760 2020
49
Understanding breast asymmetry and its relation to AIS. 61
32065382 2020
50
The variability in the management of acute surgical site infections: an opportunity for the development of a best practice guideline. 61
32077083 2020
51
A novel scoliosis instrumentation using special superelastic nickel-titanium shape memory rods: a biomechanical analysis using a calibrated computer model and data from a clinical trial. 61
32096138 2020
52
More severe thoracic idiopathic scoliosis is associated with a greater three-dimensional loss of thoracic kyphosis. 61
32488764 2020
53
Selection of Distal Fusion Level for Lenke 5 Curve: Does the Rotation of the Presumed Lower Instrumented Vertebra Matter? 61
31923131 2020
54
Asymmetric Expression of Wnt/B-catenin Pathway in AIS: Primary or Secondary to the Curve? 61
32044811 2020
55
Back pain in adolescents with idiopathic scoliosis: the contribution of morphological and psychological factors. 61
32519028 2020
56
ALG12-CDG: An unusual patient without intellectual disability and facial dysmorphism, and with a novel variant. 61
32530140 2020
57
[Conservative and surgical treatment of idiopathic scoliosis]. 61
32542427 2020
58
Surgeon volume affects short- and long-term surgical outcomes in idiopathic scoliosis. 61
32096129 2020
59
A randomised controlled trial of fibrinogen concentrate during scoliosis surgery. 61
32500569 2020
60
Response to letter to editor regarding "Core stabilization exercises versus scoliosis-specific exercises in moderate idiopathic scoliosis treatment" by Yagci and Yakut (2019). 61
32524896 2020
61
The amount of surgical correction of the main thoracic curve is the best predictor of postoperative clinical shoulder balance in patients with Adolescent Idiopathic Scoliosis. 61
32458258 2020
62
Implementation of a perioperative surgical home model for adolescent idiopathic scoliosis and its impact on acute pain and length of stay. 61
32442833 2020
63
Health-related quality of life (HRQOL) of adolescent idiopathic scoliosis (AIS) patients from surgery to after 30 years using SRS-22 questionnaire. 61
32415622 2020
64
Analysis of reciprocal changes in upper cervical profiles after posterior spinal fusion with the simultaneous double rod rotation technique for adolescent idiopathic scoliosis. 61
32409272 2020
65
Accuracy of rib cage parameters from 3-Dimensional reconstruction images obtained using simultaneous biplanar radiographic scanning technique in adolescent idiopathic scoliosis: Comparison with conventional computed tomography. 61
32178993 2020
66
A 10-Year Radiographic Study Comparing Anterior Versus Posterior Instrumented Spinal Fusion in Patients With Lenke Type 5 Adolescent Idiopathic Scoliosis. 61
31770332 2020
67
Sequential MRI reveals vertebral body wedging significantly contributes to coronal plane deformity progression in adolescent idiopathic scoliosis during growth. 61
32451976 2020
68
The Intelligent Automated Pressure-Adjustable Orthosis for Patients with Adolescent Idiopathic Scoliosis (AIS): A Bi-Center Randomized Controlled Trial. 61
32453223 2020
69
A 3D Parameter Can Guide Concave Rod Contour for the Correction of Hypokyphosis in Adolescent Idiopathic Scoliosis. 61
32453225 2020
70
Postoperative T1 tilt is a risk factor for postoperative distal adding-on in Lenke type 1 adolescent idiopathic scoliosis: A preliminary report. 61
32481263 2020
71
How do we follow-up patients with adolescent idiopathic scoliosis? Recommendations based on a multicenter study on the distal radius and ulna classification. 61
32377896 2020
72
Idiopathic scoliosis: A pilot MR study of early vertebral morphological changes and spinal asymmetry. 61
32025128 2020
73
Predicting Growth Quantitatively Through Proximal Tibia Radiograph Markers. 61
32404656 2020
74
Current Trends in Pediatric Spine Deformity Surgery: Multimodal Pain Management and Rapid Recovery. 61
32313800 2020
75
Identification of the most relevant intervertebral effort indicators during gait of adolescents with idiopathic scoliosis. 61
32401544 2020
76
Intraoperative neurophysiological monitoring during scoliosis surgery in patients with Duchenne muscular dystrophy. 61
32440770 2020
77
Nutrition and physical activity level of adolescents with idiopathic scoliosis: a narrative review. 61
31783126 2020
78
The accuracy of Cobb angle measurement on CT scan projection radiograph images. 61
32052770 2020
79
Hypomagnesemia following posterior spinal fusion in adolescent idiopathic scoliosis. 61
32371649 2020
80
Posterior Correction Techniques for Adolescent Idiopathic Scoliosis. 61
31633657 2020
81
Impact of pelvic obliquity on coronal alignment in patients with adolescent idiopathic scoliosis. 61
32458257 2020
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Impact of unoperated adolescent idiopathic scoliosis in adulthood: a 10-year analysis. 61
32468383 2020
83
Evaluation of choroidal changes in adolescent idiopathic scoliosis using enhanced depth imaging optical coherence tomography. 61
31210383 2020
84
Fusions ending above the sagittal stable vertebrae in adolescent idiopathic scoliosis: does it matter? 61
32405718 2020
85
Deformity correction using proximal hooks and distal screws (PHDSs) improves radiological metrics in adolescent idiopathic scoliosis. 61
32405796 2020
86
Assessment of serum vitamin D levels in surgical adolescent idiopathic scoliosis patients. 61
32393207 2020
87
Opioid prescribing practices after posterior spinal arthrodesis for adolescent idiopathic scoliosis. 61
32378042 2020
88
A Predictive Model of Progression for Adolescent Idiopathic Scoliosis Based on 3D Spine Parameters at First Visit. 61
31703055 2020
89
Thoracoscopic Vertebral Body Tethering for Adolescent Idiopathic Scoliosis: A Minimum of 2 Years' Results of 21 Patients. 61
32427800 2020
90
Use of Pheno Room, Augmented Reality, and 3-Rod Technique for 3-Dimensional Correction of Adolescent Idiopathic Scoliosis. 61
31982598 2020
91
Predictability of Coronal Curve Flexibility in Postoperative Curve Correction in Adolescent Idiopathic Scoliosis: The Effect of the Sagittal Profile. 61
32313796 2020
92
Preoperative Assessment of the Feasibility of Pedicle Screw Insertion at the Proximal Thoracic Curve in Lenke Type 2 Idiopathic Scoliosis. 61
32313790 2020
93
Evaluation of upper extremity function and its relation to curve pattern in female adolescents with idiopathic scoliosis: a pilot study. 61
32474902 2020
94
Efficacy of bracing in skeletally immature patients with moderate-severe idiopathic scoliosis curves between 40° and 60°. 61
32394324 2020
95
What Is the Role of Anterior Vertebral Tethering?: Commentary on an article by Peter O. Newton, MD, et al.: "Anterior Spinal Growth Modulation in Skeletally Immature Patients with Idiopathic Scoliosis. A Comparison with Posterior Spinal Fusion at 2 to 5 Years Postoperatively". 61
32379129 2020
96
Anterior Spinal Growth Modulation in Skeletally Immature Patients with Idiopathic Scoliosis: A Comparison with Posterior Spinal Fusion at 2 to 5 Years Postoperatively. 61
32379117 2020
97
Intraoperative Radiation Exposure for Patients with Double-Curve Idiopathic Scoliosis in Freehand-Technique in Comparison to Fluoroscopic- and CT-Based Navigation. 61
32365396 2020
98
Intraoperative radiation exposure to patients in idiopathic scoliosis surgery with freehand insertion technique of pedicle screws and comparison to navigation techniques. 61
32447530 2020
99
Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. 61
32088216 2020
100
The Filum disease and the Neuro-Cranio-vertebral syndrome: definition, clinical picture and imaging features. 61
32393196 2020
101
Development and validation of a bespoke phantom to test accuracy of Cobb angle measurements. 61
32052769 2020
102
Dysregulation of the ghrelin/RANKL/OPG pathway in bone mass is related to AIS osteopenia. 61
32087335 2020
103
Two AIS spine surgeries on the same day by the same surgeon: is performance and outcome the same for the second patient? 61
32447574 2020
104
Reliable skeletal maturity assessment for an AIS patient cohort: external validation of the proximal humerus ossification system (PHOS) and relevant learning methodology. 61
32385841 2020
105
Non-Pedicular Fixation Techniques for the Treatment of Spinal Deformity: A Systematic Review. 61
32427778 2020
106
The implant density does not change the correction rate of the main and the accompanying curves: A comparison between consecutive and intermittent pedicle screw constructs. 61
32544065 2020
107
Clinical Outcomes of Idiopathic Scoliosis Surgery: Is There a Difference Between Young Adult Patients and Adolescent Patients? 61
32542171 2020
108
Validation of the Korean Version of the Body Image Disturbance Questionnaire-Scoliosis. 61
31770342 2020
109
One stage or two? A cohort analysis of anterior-posterior spinal fusions for severe pediatric scoliosis. 61
32399683 2020
110
Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine. 61
32409296 2020
111
Body Awareness and its Relation to Quality of Life in Individuals with Idiopathic Scoliosis. 61
32423304 2020
112
Awake serial body casting for the management of infantile idiopathic scoliosis: is general anesthesia necessary? 61
32383143 2020
113
Construct validity of the Trunk Aesthetic Clinical Evaluation (TRACE) in young people with idiopathic scoliosis. 61
31816447 2020
114
Prediction of clinical height gain from surgical posterior correction of idiopathic scoliosis. 61
32470942 2020
115
Effect of elastic scapular taping on shoulder and spine kinematics in adolescents with idiopathic scoliosis. 61
32442121 2020
116
Persistent low-normal bone mineral density in adolescent idiopathic scoliosis with different curve severity: A longitudinal study from presentation to beyond skeletal maturity and peak bone mass. 61
31891787 2020
117
Defining criteria for optimal lumbar curve correction following the selective thoracic fusion surgery in Lenke 1 adolescent idiopathic scoliosis: developing a decision tree. 61
31760495 2020
118
Impact of metal density on deformity correction in posterior fusions for adolescent idiopathic scoliosis: A retrospective cohort study. 61
32211188 2020
119
Safety and effectiveness of minimally invasive scoliosis surgery for adolescent idiopathic scoliosis: a retrospective case series of 84 patients. 61
31637547 2020
120
Residual thoracolumbar/lumbar curve is related to self-image after posterior spinal fusion for Lenke 1 and 2 curves in adolescent idiopathic scoliosis patients. 61
32330894 2020
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Selecting the C7-LIV Line Vertebra as the Upper Instrumented Vertebra for Adolescent Idiopathic Scoliosis Lenke Type 1A Curves: Multicenter and a Minimum 2-year Follow-up Study. 61
32355137 2020
122
Does image guidance decrease pedicle screw-related complications in surgical treatment of adolescent idiopathic scoliosis: a systematic review update and meta-analysis. 61
31781863 2020
123
The effect of added fat on the accuracy of Cobb angle measurements in CT SPR images: A phantom study. 61
32340911 2020
124
The effect of vertebral body stapling on spine biomechanics and structure using a bovine model. 61
32145672 2020
125
Delayed quadriparesis after posterior spinal fusion for scoliosis: a case series. 61
32274769 2020
126
Anaphylaxis secondary to albumin infusion during posterior spinal fusion for pediatric scoliosis. 61
32030641 2020
127
Scoliosis-specific exercises: A state of the Art Review. 61
32096136 2020
128
Emerging Techniques in Diagnostic Imaging for Idiopathic Scoliosis in Children and Adolescents: A Review of the Literature. 61
31954891 2020
129
Outcome of Posterior-Only Approach for Severe Rigid Scoliosis: A Retrospective Report. 61
32355631 2020
130
Preoperative SRS pain score is the primary predictor of postoperative pain after surgery for adolescent idiopathic scoliosis: an observational retrospective study of pain outcomes from a registry of 1744 patients with a mean follow-up of 3.4 years. 61
31993788 2020
131
Removal of a urinary catheter before discontinuation of epidural analgesia is associated with an increased risk of postoperative urinary retention and hospital episode costs in patients undergoing surgical correction for adolescent idiopathic scoliosis. 61
31981148 2020
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Correction to: Removal of a urinary catheter before discontinuation of epidural analgesia is associated with an increased risk of postoperative urinary retention and hospital episode costs in patients undergoing surgical correction for adolescent idiopathic scoliosis. 61
32124400 2020
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Correction to: Evaluation of a new sagittal classification system in adolescent idiopathic scoliosis. 61
31993786 2020
134
Shear wave elastography of lumbar annulus fibrosus in adolescent idiopathic scoliosis before and after surgical intervention. 61
31834510 2020
135
Complications following surgery for adolescent idiopathic scoliosis over a 13-year period. 61
32228070 2020
136
Curve severity and apical vertebral rotation and their association with curve flexibility in adolescent idiopathic scoliosis. 61
32323201 2020
137
Fusions ending at the thoracolumbar junction in adolescent idiopathic scoliosis: comparison of lower instrumented vertebrae. 61
32026437 2020
138
Surface topography assessment of body shape after surgical correction in adolescent idiopathic scoliosis. 61
32030642 2020
139
Dedicated spine nurses and scrub technicians improve intraoperative efficiency of surgery for adolescent idiopathic scoliosis. 61
32096134 2020
140
Quantitation Analysis of PCDH10 Methylation in Adolescent Idiopathic Scoliosis Using Pyrosequencing Study. 61
31651684 2020
141
Impact of Pregnancy on Loss of Deformity Correction After Pedicle Screw Instrumentation for Adolescent Idiopathic Scoliosis. 61
32272267 2020
142
Geographic Variation in Outcomes and Costs After Spinal Fusion for Adolescent Idiopathic Scoliosis. 61
31917315 2020
143
Evaluation of a new sagittal classification system in adolescent idiopathic scoliosis. 61
31802239 2020
144
Abnormal paravertebral muscles development is associated with abnormal expression of PAX3 in adolescent idiopathic scoliosis. 61
31832874 2020
145
Spine slenderness and wedging in adolescent idiopathic scoliosis and in asymptomatic population: an observational retrospective study. 61
32072270 2020
146
Alterations of 3D acetabular and lower limb parameters in adolescent idiopathic scoliosis. 61
32246232 2020
147
Surgical treatment of adolescent idiopathic scoliosis: Complications. 61
32153775 2020