Idiopathic Scoliosis

Categories: Bone diseases

Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 6 15
Scoliosis Idiopathic 54


External Ids:

Disease Ontology 12 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to scheuermann disease and strabismus. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2). The drugs Cyclobenzaprine and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related phenotypes are limbs/digits/tail and skeleton

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 scheuermann disease 29.8 PAX1 C17orf67
2 strabismus 28.8 VANGL1 CHD7 CELSR2
3 scoliosis 27.2 VANGL1 SNTG1 POC5 PAX1 MTNR1B MATN1
4 scoliosis, isolated 1 12.5
5 scoliosis, isolated 3 12.1
6 horizontal gaze palsy with progressive scoliosis 11.6
7 scoliosis, isolated 2 11.5
8 scoliosis, isolated 4 11.5
9 scoliosis, isolated 5 11.5
10 back pain 10.8
11 overgrowth syndrome 10.5
12 syringomyelia, noncommunicating isolated 10.5
13 syringomyelia 10.5
14 non-alcoholic steatohepatitis 10.5
15 chiari malformation 10.5
16 bone mineral density quantitative trait locus 3 10.4
17 pain agnosia 10.4
18 spondylolisthesis 10.4
19 body mass index quantitative trait locus 1 10.4
20 respiratory failure 10.3
21 infantile scoliosis 10.3
22 hand skill, relative 10.3
23 polykaryocytosis inducer 10.3
24 degenerative disc disease 10.3
25 spinal cord injury 10.3
26 virus-associated trichodysplasia spinulosa 10.3
27 pneumothorax 10.3
28 47,xyy 10.3
29 spinal disease 10.2
30 myopathy 10.2
31 chiari malformation type ii 10.2
32 orthostatic intolerance 10.2
33 spondylolysis 10.2
34 neuromuscular disease 10.2
35 ileus 10.2
36 hypermobile ehlers-danlos syndrome 10.2
37 48,xyyy 10.2
38 chronic pain 10.2
39 marfan syndrome 10.1
40 osteoporosis 10.1
41 pectus excavatum 10.1
42 bone mineral density quantitative trait locus 8 10.1
43 bone mineral density quantitative trait locus 15 10.1
44 leukemia, acute lymphoblastic 3 10.1
45 bone resorption disease 10.1
46 rickets 10.1
47 constipation 10.1
48 lung disease 10.1
49 pathologic nystagmus 10.1
50 pik3ca-related overgrowth syndrome 10.1

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:

Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.43 CHD7 COL1A2 FBN1 LBX1 PAX1 VANGL1
2 skeleton MP:0005390 9.23 ADGRG6 BNC2 CHD7 COL1A2 FBN1 MATN1

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Cyclobenzaprine Approved Phase 4 303-53-7 2895
Thrombin Approved, Investigational Phase 4
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
Cefazolin Approved Phase 4 25953-19-9 656510 33255
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
13 Acetaminophen, hydrocodone drug combination Phase 4
14 Central Nervous System Depressants Phase 4
15 Analgesics Phase 4
16 Anesthetics, Intravenous Phase 4
17 Anesthetics, General Phase 4
18 Anesthetics, Dissociative Phase 4
19 Excitatory Amino Acid Antagonists Phase 4
20 Excitatory Amino Acids Phase 4
21 Hemostatics Phase 4
22 Antifibrinolytic Agents Phase 4
23 Coagulants Phase 4
24 Antimanic Agents Phase 4
25 Analgesics, Non-Narcotic Phase 4
26 Calcium, Dietary Phase 4
27 Hormones Phase 4
28 Narcotics Phase 4
29 Analgesics, Opioid Phase 4
30 Dialysis Solutions Phase 4
31 Anti-Bacterial Agents Phase 4
32 Tranquilizing Agents Phase 4
33 Anti-Anxiety Agents Phase 4
34 Psychotropic Drugs Phase 4
35 Anticonvulsants Phase 4
36 calcium channel blockers Phase 4
37 Neurotransmitter Agents Phase 4
38 Acetylcholine Release Inhibitors Phase 4
39 abobotulinumtoxinA Phase 4
40 Neuromuscular Agents Phase 4
41 Botulinum Toxins Phase 4
42 Cholinergic Agents Phase 4
43 Botulinum Toxins, Type A Phase 4
Calcium carbonate Approved, Investigational Phase 3 471-34-1
Clevidipine Approved, Investigational Phase 2, Phase 3 167221-71-8
Morphine Approved, Investigational Phase 3 57-27-2 5288826
Methadone Approved Phase 3 76-99-3 4095
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
50 Gastrointestinal Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 165)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Unknown status NCT02651324 Phase 4 Ketamine
2 Effectiveness Of Gelatin Matrix With Human Derived Thrombin On Blood Loss, Surgical Time, Hospital Stay And Complications In Adolescents Undergoing Spine Surgery For Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial. Unknown status NCT01451788 Phase 4
3 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
4 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
5 Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents Completed NCT01325493 Phase 4 Ketamine;Normal Saline
6 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
7 Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction Completed NCT01977937 Phase 4 Gabapentin 250mg/5mL NDC:59762-5025-01;Simple Syrup
8 A Prospective, Randomized, Double-blinded Single-site Control Study Comparing Blood Loss Prevention of Tranexamic Acid (TXA) to Epsilon Aminocaproic Acid (EACA) for Corrective Spinal Surgery Completed NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
9 Skeletal Muscle and Adipose Tissue Concentrations of Cefazolin Comparing Two Different Dosing Regimens During Pediatric Posterior Spinal Fusion Surgery Recruiting NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
10 Intravenous Lidocaine to Reduce Postoperative Opioid Consumption and Improve Recovery After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Recruiting NCT03893318 Phase 4 IV lidocaine;Placebos
11 Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery. Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
12 The Use of Botulinum Toxin A Injections As An Adjunct to Bracing to Treat Adolescent Idiopathic Scoliosis Not yet recruiting NCT03935295 Phase 4 AbobotulinumtoxinA;Placebos
13 Perioperative Outcomes of Multilevel Posterior Spinal Fusion in Adolescent Scoliosis With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
14 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Withdrawn NCT00768313 Phase 4
15 Can Calcium and Vitamin D Supplementation Improve Bone Mineral Density and Curve Progression in Girls With Adolescent Idiopathic Scoliosis? Completed NCT01103115 Phase 3
16 Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial Completed NCT01108211 Phase 3
17 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
18 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
19 Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children. Completed NCT00323752 Phase 3
20 The Use of Perioperative Gabapentin in Adolescents Undergoing Posterior Spinal Fusion for Idiopathic Scoliosis to Prevent Chronic Postsurgical Pain, a Pilot Study. Recruiting NCT03867240 Phase 3 Gabapentin
21 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Recruiting NCT02558010 Phase 3 Methadone;Morphine
22 The Effects of Fibrinogen Concentrate Infusion on Perioperative Blood Loss and Allogeneic Blood Conservation in Patients Undergoing Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
23 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Active, not recruiting NCT02285621 Phase 3
24 Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children Not yet recruiting NCT04069169 Phase 3 Lidocaine;Saline Solution
25 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
26 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
27 The Efficacy of Intravenous Tranexamic Acid in Decreasing Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
28 Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
29 Analgesia Following Posterior Spinal Fusion: Methadone vs Magnesium Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
30 Ultrasound Guided Erector Spinae Plane Block in Scoliotic Adolescents Undergoing Posterior Spine Instrumentation . A Randomized Controlled Trial Completed NCT03968146 Phase 2 Fentanyl;additional Fentanyl;Morphine;rescue Morphine;pethidine;Ketorolac;Acetaminophen
31 Blood Loss and Transfusion Requirement in Pediatric Patients With Non-Idiopathic Scoliosis Treated With Tranexamic Acid Undergoing Posterior Spinal Instrumentation and Fusion. Terminated NCT01089140 Phase 2 Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
32 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics During Static and Dynamic Activities in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
33 An Innovative Body-Mapping Tank Top Equipped With Biofeedback System for Adolescents With Early Scoliosis Completed NCT02471508 Phase 1
34 Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery Completed NCT00357851 Phase 1 Aprotinin
35 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245
36 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
37 Effect of the Severity and the Treatment (Orthosis Versus Surgery)of the Idiopathic Scoliosis on the Locomotor Mechanism of the Gait. Unknown status NCT00842218
38 A Randomized Controlled Trial: Comparison of a Top Loading MESA® Spinal System With MESA Rail™ and a Side Locking Pedicle Screw System for the Treatment of Adolescent Paediatric Spine Deformity Unknown status NCT02590380
39 Efficacy and Safety of Desmopressin Combined With Tranexamic Acid on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
40 Scoliosis-Specific Exercises for At-Risk Mild Adolescent Idiopathic Scoliosis Curves: A Multi-Site Preliminary Randomized Trial Unknown status NCT02807545
41 Idiopathic Scoliosis Treated by Posterior Spinal Instrumentation. Evaluation of the 3D Correction, Aesthetic Outcomes and Quality of Life. Completed NCT01019109
42 Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Completed NCT03539770
43 Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients Completed NCT03820895
44 Idiopathic Scoliosis Surgery in Adolescents ; Earnings a Multidisciplinary Management of Pain and Quality of Life Completed NCT02890654
45 Effect of Conservative Treatment on Pulmonary Functions, Gait Oxygen Consumption Balance and Lower Limb Load Distribution in Adolescents With Idiopathic Scoliosis Completed NCT03514082
46 Evaluation of an Anesthetic Optimization Technique in Adolescent Idiopathic Scoliosis Surgery Completed NCT02481570
47 The Effect of Core Stabilization Training on Respiratory Parameters, Peripheral Muscle Strength, Balance, Functional Capacity and Quality of Life in Children With Adolescent Idiopathic Scoliosis Completed NCT03823053
48 The Effect of the Inspiratory Muscle Training on Respiratory Muscle Strength, Respiratory Function and Functional Capacity in Adolescents With Idiopathic Scoliosis Completed NCT03391895
49 A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace Completed NCT01336114
50 Single-blind Comprehensive Cohort Study Incorporating a Randomized Controlled Design on Bracing in AIS: A Feasibility Study Completed NCT00989495

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

MalaCards organs/tissues related to Idiopathic Scoliosis:

Bone, Testes, Spinal Cord, Lung, Heart, Brain, Breast

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 6888)
# Title Authors PMID Year
Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. 54 61
17632395 2007
[Expression of calmodulin and nNOS in the paraspinal muscles in idiopathic scoliosis]. 54 61
15387945 2004
[Expression of neuronal nitric oxide synthase and inducible nitric oxide synthase in the erector spinal muscles in idiopathic scoliosis]. 54 61
15379275 2004
Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis. 54 61
8982144 1996
Idiopathic scoliosis: A pilot MR study of early vertebral morphological changes and spinal asymmetry. 61
32025128 2020
Is It Growth or Natural History? Increasing Spinal Deformity After Sanders Stage 7 in Females With AIS. 61
31181026 2020
High Satisfaction in Adolescent Idiopathic Scoliosis Patients on Enhanced Discharge Pathway. 61
31403990 2020
Is Anterior Release Obsolete or Does It Play a Role in Contemporary Adolescent Idiopathic Scoliosis Surgery? A Matched Pair Analysis. 61
31368923 2020
Demonstration of asymmetric muscle perfusion of the back after exercise in patients with adolescent idiopathic scoliosis using intravoxel incoherent motion (IVIM) MRI. 61
31815323 2020
The Influence of Body Habitus on Documented Brace Wear and Progression in Adolescents With Idiopathic Scoliosis. 61
31259783 2020
Comparison of EOSQ-24 and SRS-22 Scores in Congenital Scoliosis: A Preliminary Study. 61
31157754 2020
Bone health in adolescents with idiopathic scoliosis. 61
32009439 2020
Surface topography assessment of body shape after surgical correction in adolescent idiopathic scoliosis. 61
32030642 2020
Does Curve Regression Occur During Underarm Bracing in Patients with Adolescent Idiopathic Scoliosis? 61
31688210 2020
CORR Insights®: Does Curve Regression Occur During Underarm Bracing in Patients with Adolescent Idiopathic Scoliosis? 61
31794490 2020
Patient-reported Outcomes Following Surgical Intervention for Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis. 61
30925497 2020
A Novel Coding Variant in SLC39A8 Is Associated With Adolescent Idiopathic Scoliosis in Chinese Han Population. 61
31513097 2020
Use of a novel corrective device for correction of deformities in adolescent idiopathic scoliosis. 61
31104287 2020
Patient-specific rods for thoracic kyphosis correction in adolescent idiopathic scoliosis surgery: Preliminary results. 61
31757655 2020
Fusions ending at the thoracolumbar junction in adolescent idiopathic scoliosis: comparison of lower instrumented vertebrae. 61
32026437 2020
Establishing consensus on the best practice guidelines for the use of bracing in adolescent idiopathic scoliosis. 61
32026441 2020
Supine flexibility predicts curve progression for patients with adolescent idiopathic scoliosis undergoing underarm bracing. 61
32009436 2020
What's Important: Moving Beyond "Idiopathic" in Adolescent Idiopathic Scoliosis. 61
31725121 2020
Rib Regeneration Morphology After Thoracoplasty in Adolescent Idiopathic Scoliosis. 61
31464973 2020
Towards a new 3D classification for adolescent idiopathic scoliosis. 61
32026444 2020
A systematic literature review of spinal brace/orthosis treatment for adults with scoliosis between 1967 and 2018: clinical outcomes and harms data. 61
32035480 2020
Safety and Effectiveness of Antifibrinolytics in Posterior Scoliosis Surgery for Adolescent Idiopathic Scoliosis: An Analysis of the NSQIP-Pediatric Database. 61
31162181 2020
What is the most reliable radiographic method to evaluate the longitudinal foot arch? Application in subjects with Adolescent Idiopathic Scoliosis. 61
32035816 2020
Changes in the Position of the Junctional Vertebrae After Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis: Implication in Risk Assessment of Proximal Junctional Kyphosis Development. 61
31095012 2020
High Risk of Mismatch Between Sanders and Risser Staging in Adolescent Idiopathic Scoliosis: Are We Guiding Treatment Using the Wrong Classification? 61
31923164 2020
A Positive (+ve) Postoperative Upper Instrumented Vertebra Tilt Angle (≥0°) Significantly Increases the Risk of Medial Shoulder and Neck Imbalance in Lenke 1 and 2 Adolescent Idiopathic Scoliosis Patients. 61
32032325 2020
The 100 Top-Cited Articles on Spinal Deformity: A Bibliometric Analysis. 61
31999653 2020
Multimodal pain control in adolescent posterior spinal fusion patients: a double-blind, randomized controlled trial to validate the effect of gabapentin on postoperative pain control, opioid use, and patient satisfaction. 61
32026435 2020
Risk Factors for Postoperative Distal Adding-on in Lenke Type 1B and 1C and its Influence on Residual Lumbar Curve. 61
31095011 2020
Preemptive Pregabalin in Children and Adolescents Undergoing Posterior Instrumented Spinal Fusion: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. 61
31770296 2020
FoxD1-driven CCN2 deletion causes axial skeletal deformities, pulmonary hypoplasia, and neonatal asphyctic death. 61
32020419 2020
Anaphylaxis secondary to albumin infusion during posterior spinal fusion for pediatric scoliosis. 61
32030641 2020
The Tampa Scale of Kinesiophobia: Structural Validation among Adolescents with Idiopathic Scoliosis Undergoing Spinal Fusion Surgery. 61
32028813 2020
Continued vertebral body growth in patients with juvenile idiopathic scoliosis following vertebral body stapling. 61
32026438 2020
Can Breast Asymmetry Following the Treatment of Juvenile Idiopathic Scoliosis with Growing Rod Be Prevented? : A Preliminary Analysis. 61
32024355 2020
Sagittal Balance in Adult Idiopathic Scoliosis. 61
31913179 2020
CHD7 gene polymorphisms in female patients with idiopathic scoliosis. 61
31924193 2020
Somatosensory and motor evoked potentials during correction surgery of scoliosis in neurologically asymptomatic Chiari malformation-associated scoliosis: A comparison with idiopathic scoliosis. 61
32006930 2020
Prevalence of Hip Dysplasia and Associated Conditions in Children Treated for Idiopathic Early-onset Scoliosis-Don't Just Look at the Spine. 61
30994578 2020
Prevalence of Adolescent Idiopathic Scoliosis in Turkey: An Epidemiological Study. 61
31972303 2020
Leptin in adolescent idiopathic scoliosis - A meta-analysis. 61
31493992 2020
Adolescent Idiopathic Scoliosis: Common Questions and Answers. 61
31894928 2020
Rib Cage Measurement Reproducibility Using Biplanar Stereoradiographic 3D Reconstructions in Adolescent Idiopathic Scoliosis. 61
31815860 2020
Bivertebral autostable claws for the proximal fixation in thoracic adolescent idiopathic scoliosis surgery. 61
31950478 2020
Factors affecting length of stay after posterior spinal fusion for adolescent idiopathic scoliosis. 61
31960355 2020

Variations for Idiopathic Scoliosis

ClinVar genetic disease variations for Idiopathic Scoliosis:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CELSR2 NM_001408.3(CELSR2):c.6859G>A (p.Val2287Ile)SNV Uncertain significance 397652 rs141489111 1:109812092-109812092 1:109269470-109269470

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

GO Terms for Idiopathic Scoliosis

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 camera-type eye development GO:0043010 9.13 MTNR1B FBN1 CHD7
2 skeletal system development GO:0001501 8.92 PAX1 FBN1 COL1A2 CHD7

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.8 MATN1 FBN1 COL1A2

Sources for Idiopathic Scoliosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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