Idiopathic Scoliosis

Categories: Bone diseases

Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 6 15
Scoliosis Idiopathic 54


External Ids:

Disease Ontology 12 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to orthostatic intolerance and marfan syndrome. An important gene associated with Idiopathic Scoliosis is CHL1-AS2 (CHL1 Antisense RNA 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. The drugs Cyclobenzaprine and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 29.7 FBN2 FBN1 COL1A2
2 marfan syndrome 29.5 FBN2 FBN1 COL1A2
3 ehlers-danlos syndrome 29.3 FBN2 FBN1 COL1A2
4 distal arthrogryposis 29.1 LBX1 FBN2 FBN1 ADGRG6
5 scoliosis 27.4 VANGL1 SNTG1 POC5 PAX1 MTNR1B MATN1
6 scoliosis, isolated 1 12.6
7 scoliosis, isolated 3 12.1
8 horizontal gaze palsy with progressive scoliosis 11.6
9 scoliosis, isolated 2 11.5
10 scoliosis, isolated 4 11.5
11 scoliosis, isolated 5 11.5
12 back pain 10.8
13 overgrowth syndrome 10.6
14 syringomyelia, noncommunicating isolated 10.5
15 syringomyelia 10.5
16 chiari malformation 10.5
17 bone mineral density quantitative trait locus 3 10.4
18 spondylolisthesis 10.4
19 body mass index quantitative trait locus 1 10.4
20 pain agnosia 10.4
21 infantile scoliosis 10.4
22 respiratory failure 10.3
23 hand skill, relative 10.3
24 polykaryocytosis inducer 10.3
25 scheuermann disease 10.3
26 degenerative disc disease 10.3
27 virus-associated trichodysplasia spinulosa 10.3
28 spinal disease 10.3
29 pneumothorax 10.3
30 47,xyy 10.3
31 spinal cord injury 10.3
32 myopathy 10.2
33 48,xyyy 10.2
34 scleredema adultorum 10.2 MATN1 FBN1
35 chiari malformation type ii 10.2
36 rickets 10.2
37 spondylolysis 10.2
38 neuromuscular disease 10.2
39 ileus 10.2
40 hypermobile ehlers-danlos syndrome 10.2
41 chronic pain 10.2
42 osteoporosis 10.1
43 pectus excavatum 10.1
44 bone mineral density quantitative trait locus 8 10.1
45 bone mineral density quantitative trait locus 15 10.1
46 leukemia, acute lymphoblastic 3 10.1
47 bone resorption disease 10.1
48 constipation 10.1
49 pathologic nystagmus 10.1
50 pik3ca-related overgrowth syndrome 10.1

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:

Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 ADGRG6 BNC2 CELSR2 CHD7 COL1A2 ESR2
2 growth/size/body region MP:0005378 10.11 ADGRG6 BNC2 CELSR2 CHD7 COL1A2 ESR2
3 cardiovascular system MP:0005385 10.06 ADGRG6 CHD7 COL1A2 ESR2 FBN1 FBN2
4 limbs/digits/tail MP:0005371 9.92 CHD7 COL1A2 ESR2 FBN1 FBN2 LBX1
5 muscle MP:0005369 9.86 ADGRG6 CHD7 COL1A2 ESR2 FBN1 FBN2
6 nervous system MP:0003631 9.85 ADGRG6 CELSR2 CHD7 COL1A2 ESR2 FBN1
7 reproductive system MP:0005389 9.56 CELSR2 CHD7 ESR2 FBN1 FBN2 PAX1
8 skeleton MP:0005390 9.32 ADGRG6 BNC2 CHD7 COL1A2 ESR2 FBN1

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Cyclobenzaprine Approved Phase 4 303-53-7 2895
Thrombin Approved, Investigational Phase 4
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Cefazolin Approved Phase 4 25953-19-9 656510 33255
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
11 Acetaminophen, hydrocodone drug combination Phase 4
12 Anesthetics, Intravenous Phase 4
13 Excitatory Amino Acid Antagonists Phase 4
14 Anesthetics, Dissociative Phase 4
15 Analgesics Phase 4
16 Anesthetics, General Phase 4
17 Neurotransmitter Agents Phase 4
18 Hemostatics Phase 4
19 Antifibrinolytic Agents Phase 4
20 Coagulants Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Analgesics, Opioid Phase 4
23 Hormones Phase 4
24 Calcium, Dietary Phase 4
25 Psychotropic Drugs Phase 4
26 Anti-Anxiety Agents Phase 4
27 Anticonvulsants Phase 4
28 Narcotics Phase 4
29 calcium channel blockers Phase 4
30 Anti-Bacterial Agents Phase 4
31 Dialysis Solutions Phase 4
32 Anti-Infective Agents Phase 4
33 abobotulinumtoxinA Phase 4
34 Cholinergic Agents Phase 4
35 Botulinum Toxins Phase 4
36 Botulinum Toxins, Type A Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Calcium carbonate Approved, Investigational Phase 3 471-34-1
Clevidipine Approved, Investigational Phase 2, Phase 3 167221-71-8
Morphine Approved, Investigational Phase 3 57-27-2 5288826
Methadone Approved Phase 3 76-99-3 4095
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
44 Gastrointestinal Agents Phase 3
45 Antacids Phase 3
46 Anti-Ulcer Agents Phase 3
47 Respiratory System Agents Phase 3
48 Antitussive Agents Phase 3
49 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
50 Anesthetics Phase 3

Interventional clinical trials:

(show top 50) (show all 178)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Unknown status NCT02651324 Phase 4 Ketamine
2 Effectiveness Of Gelatin Matrix With Human Derived Thrombin On Blood Loss, Surgical Time, Hospital Stay And Complications In Adolescents Undergoing Spine Surgery For Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial. Unknown status NCT01451788 Phase 4
3 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
4 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
5 Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents Completed NCT01325493 Phase 4 Ketamine;Normal Saline
6 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
7 The Effects of Fibrinogen Concentrate Infusion on Perioperative Blood Loss and Allogeneic Blood Conservation in Patients Undergoing Scoliosis Surgery Completed NCT03183479 Phase 4 Fibrinogen Concentrate Human;Normal saline
8 Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction Completed NCT01977937 Phase 4 Gabapentin 250mg/5mL NDC:59762-5025-01;Simple Syrup
9 A Prospective, Randomized, Double-blinded Single-site Control Study Comparing Blood Loss Prevention of Tranexamic Acid (TXA) to Epsilon Aminocaproic Acid (EACA) for Corrective Spinal Surgery Completed NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
10 Intravenous Lidocaine to Reduce Postoperative Opioid Consumption and Improve Recovery After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Recruiting NCT03893318 Phase 4 IV lidocaine;Placebos
11 Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery. Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
12 Skeletal Muscle and Adipose Tissue Concentrations of Cefazolin Comparing Two Different Dosing Regimens During Pediatric Posterior Spinal Fusion Surgery Active, not recruiting NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
13 Dysport ® (abobotulinumtoxinA) as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis Not yet recruiting NCT03935295 Phase 4 AbobotulinumtoxinA;Placebos
14 Perioperative Outcomes of Multilevel Posterior Spinal Fusion in Adolescent Scoliosis With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
15 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Withdrawn NCT00768313 Phase 4
16 Can Calcium and Vitamin D Supplementation Improve Bone Mineral Density and Curve Progression in Girls With Adolescent Idiopathic Scoliosis? Completed NCT01103115 Phase 3
17 Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial Completed NCT01108211 Phase 3
18 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
19 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
20 Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children. Completed NCT00323752 Phase 3
21 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Recruiting NCT02558010 Phase 3 Methadone;Morphine
22 Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children Not yet recruiting NCT04069169 Phase 3 Lidocaine;Saline Solution
23 The Use of Perioperative Gabapentin in Adolescents Undergoing Posterior Spinal Fusion for Idiopathic Scoliosis to Prevent Chronic Postsurgical Pain, a Pilot Study. Suspended NCT03867240 Phase 3 Gabapentin
24 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
25 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
26 The Efficacy of Intravenous Tranexamic Acid in Decreasing Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
27 Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
28 Analgesia Following Posterior Spinal Fusion: Methadone vs Magnesium Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
29 Ultrasound Guided Erector Spinae Plane Block in Scoliotic Adolescents Undergoing Posterior Spine Instrumentation . A Randomized Controlled Trial Completed NCT03968146 Phase 2 Fentanyl;additional Fentanyl;Morphine;rescue Morphine;pethidine;Ketorolac;Acetaminophen
30 Blood Loss and Transfusion Requirement in Pediatric Patients With Non-Idiopathic Scoliosis Treated With Tranexamic Acid Undergoing Posterior Spinal Instrumentation and Fusion. Terminated NCT01089140 Phase 2 Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
31 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics During Static and Dynamic Activities in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
32 An Innovative Body-Mapping Tank Top Equipped With Biofeedback System for Adolescents With Early Scoliosis Completed NCT02471508 Phase 1
33 Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery Completed NCT00357851 Phase 1 Aprotinin
34 Treatment of Adolescent Idiopathic Scoliosis Patients Using the Ellipse MAGEC System Unknown status NCT01633931
35 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245
36 Application Research of Physiotherapeutic Scoliosis Specific Exercises in Adolescent Idiopathic Scoliosis Unknown status NCT02968043
37 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
38 Development of Exercise Protocol for Scoliosis Using Surface Electromyography(S-EMG) Unknown status NCT03675984
39 Effect of the Severity and the Treatment (Orthosis Versus Surgery)of the Idiopathic Scoliosis on the Locomotor Mechanism of the Gait. Unknown status NCT00842218
40 A Randomized Controlled Trial: Comparison of a Top Loading MESA® Spinal System With MESA Rail™ and a Side Locking Pedicle Screw System for the Treatment of Adolescent Paediatric Spine Deformity Unknown status NCT02590380
41 The Effect of Asymmetric Spinal Stabilization Exercise on Scoliosis Unknown status NCT03497520
42 Efficacy and Safety of Desmopressin Combined With Tranexamic Acid on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
43 A New Spinal Brace Design Concept for the Treatment of Adolescent Idiopathic Scoliosis Unknown status NCT03365804
44 Scoliosis-Specific Exercises for At-Risk Mild Adolescent Idiopathic Scoliosis Curves: A Multi-Site Preliminary Randomized Trial Unknown status NCT02807545
45 Idiopathic Scoliosis Treated by Posterior Spinal Instrumentation. Evaluation of the 3D Correction, Aesthetic Outcomes and Quality of Life. Completed NCT01019109
46 Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Completed NCT03539770
47 Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients Completed NCT03820895
48 Idiopathic Scoliosis Surgery in Adolescents ; Earnings a Multidisciplinary Management of Pain and Quality of Life Completed NCT02890654
49 Five Days of Intensive Postoperative Rehabilitation is Superior Than Mobilization in Improving Length of Hospitalization and Outcome of Patients Having Scoliosis Surgery: A Randomized Controlled Trial Completed NCT04403152
50 Effect of Conservative Treatment on Pulmonary Functions, Gait Oxygen Consumption Balance and Lower Limb Load Distribution in Adolescents With Idiopathic Scoliosis Completed NCT03514082

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

MalaCards organs/tissues related to Idiopathic Scoliosis:

Bone, Testes, Spinal Cord, Lung, Brain, Breast, Skeletal Muscle

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 7091)
# Title Authors PMID Year
Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. 54 61
17632395 2007
[Expression of neuronal nitric oxide synthase and inducible nitric oxide synthase in the erector spinal muscles in idiopathic scoliosis]. 54 61
15379275 2004
[Expression of calmodulin and nNOS in the paraspinal muscles in idiopathic scoliosis]. 61 54
15387945 2004
Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis. 54 61
8982144 1996
Feasibility of Proxy-Reported EQ-5D-3L-Y and Its Agreement in Self-reported EQ-5D-3L-Y for Patients With Adolescent Idiopathic Scoliosis. 61
32539293 2020
Changes in Cervical Spinal Alignment After Thoracolumbar Corrective Surgery in Adult Patients With Adolescent Idiopathic Scoliosis. 61
32539290 2020
Group-based Trajectory Modeling: A Novel Approach to Classifying Discriminative Functional Status Following Adult Spinal Deformity Surgery: Study of a 3-year Follow-up Group. 61
32049931 2020
Does spinal fusion influence vestibular information in scoliosis patients? Unstable equilibrium analysis. 61
32467656 2020
Correction to: Is Cutibacterium acnes early surgical site infection rate related to the duration of antibiotic prophylaxis in adolescent idiopathic scoliosis surgery? 61
32562078 2020
Comparison of Pulmonary Function After Selective Anterior Versus Posterior Fusion for the Correction of Thoracolumbar and Lumbar Adolescent Idiopathic Scoliosis. 61
32435563 2020
A Predictive Model of Progression for Adolescent Idiopathic Scoliosis Based on 3D Spine Parameters at First Visit: Erratum. 61
32472905 2020
Willingness to enroll in a surgical randomized controlled trial: patient and parent preferences regarding implant density for adolescent idiopathic scoliosis fusion. 61
32495208 2020
Associations between three-dimensional measurements of the spinal deformity and preoperative SRS-22 scores in patients undergoing surgery for major thoracic adolescent idiopathic scoliosis. 61
32488765 2020
Is it feasible to implement a rapid recovery pathway for adolescent idiopathic scoliosis patients undergoing posterior spinal instrumentation and fusion in a single-payer universal health care system? 61
32488767 2020
A Positive (+ve) Postoperative Upper Instrumented Vertebra Tilt Angle (≥0°) Significantly Increases the Risk of Medial Shoulder and Neck Imbalance in Lenke 1 and 2 Adolescent Idiopathic Scoliosis Patients. 61
32032325 2020
Letter to the Editor concerning "Safety and effectiveness of minimally invasive scoliosis surgery for adolescent idiopathic scoliosis: a retrospective case series of 84 patients" by Yang JH, et al. (Eur Spine J; [2020] 29:761-769). 61
32519029 2020
Correction to: Opioid prescribing practices after posterior spinal arthrodesis for adolescent idiopathic scoliosis. 61
32533546 2020
Exome sequencing analysis identifies frequent oligogenic involvement and FLNB variants in adolescent idiopathic scoliosis. 61
32381728 2020
What Constitutes Shoulder Imbalance in Adolescent Idiopathic Scoliosis? Aesthetic Threshold for Surgical Correction. 61
32234356 2020
Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis. 61
32548139 2020
Upregulation of cGMP-dependent Protein Kinase (PRKG1) in the Development of Adolescent Idiopathic Scoliosis. 61
32558266 2020
Operative time in adolescent idiopathic scoliosis surgery: a need for a standard definition. 61
32558776 2020
Predictors of cost for posterior spinal fusion in adolescent idiopathic scoliosis. 61
32096128 2020
Current concepts in the diagnosis and management of adolescent idiopathic scoliosis. 61
32314025 2020
Severe persistent coronal imbalance following instrumented posterior spinal fusion for adolescent idiopathic scoliosis. 61
32500442 2020
Severe adolescent idiopathic scoliosis: posterior staged correction using a temporary magnetically-controlled growing rod. 61
32506163 2020
Does bracing for adolescent idiopathic scoliosis affect operative results? 61
32291582 2020
Towards a new 3D classification for adolescent idiopathic scoliosis. 61
32026444 2020
Prevalence of adolescent idiopathic scoliosis in Turkey: an epidemiological study. 61
31972303 2020
Characterization of progressive changes in pedicle morphometry and neurovascular anatomy during growth in adolescent idiopathic scoliosis versus adolescents without scoliosis. 61
32557264 2020
Reliability Comparison between "Distal Radius and Ulna" and "Simplified Tanner-Whitehouse III" Assessments for Patients with Adolescent Idiopathic Scoliosis. 61
31992028 2020
Outcomes of pregnancy in operative vs. nonoperative adolescent idiopathic scoliosis patients at mean 30-year follow-up. 61
32578160 2020
Comparison of surgical correction rates between titanium and cobalt-chrome-alloy as rod materials in adolescent idiopathic scoliosis. 61
32572073 2020
Is daily walking distance affected in adolescent idiopathic scoliosis? An original prospective study using the pedometer on smartphones. 61
32563619 2020
Morphological Differences between the Pedicles in Nondystrophic Scoliosis Secondary to Neurofibromatosis Type 1 and Those in Adolescent Idiopathic Scoliosis. 61
32540291 2020
Impact of lowest instrumented vertebra tilt and rotation on uninstrumented lumbar curve and L4 tilt in thoracic adolescent idiopathic scoliosis. 61
32534495 2020
The Benefits of Sparing Lumbar Motion Segments in Spinal Fusion for Adolescent Idiopathic Scoliosis Are Evident at 10 Years Postoperatively. 61
31923128 2020
Incidence of scoliosis among junior high school students in Zhongshan city, Guangdong and the possible importance of decreased miR-30e expression. 61
31885345 2020
Analysis of scoliosis deformation in the Zebris computer study as an assessment of the effectiveness of the FED method in the treatment of idiopathic scolioses. 61
32564042 2020
Development: How the Reissner Fiber Keeps Our Back Straight. 61
32574632 2020
Evaluation of a new apparatus combining a mobile device and hand-held roller for the detection of spinal deformities: association with the sum of the right and left angles of trunk inclination. 61
32524285 2020
The FED-Method (Fixation, Elongation, Derotation) - a Machine-supported Treatment Approach to Patients with Idiopathic Scoliosis - Systematic Review. 61
31404938 2020
The efficacy of ketamine for postoperative pain control in adolescent patients undergoing spinal fusion surgery for idiopathic scoliosis. 61
32109313 2020
Relationship between autophagy, apoptosis and endoplasmic reticulum stress induced by melatonin in osteoblasts by septin7 expression. 61
32323792 2020
[Chest deformity as a cause of tracheobronchial compression. A pediatric case]. 61
32470279 2020
Visual Verticality Perception in Spinal Diseases: A Systematic Review and Meta-Analysis. 61
32503240 2020
SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. 61
32386528 2020
Quality improvement in post-operative opioid and benzodiazepine regimen in adolescent patients after posterior spinal fusion. 61
31925760 2020
Understanding breast asymmetry and its relation to AIS. 61
32065382 2020
The variability in the management of acute surgical site infections: an opportunity for the development of a best practice guideline. 61
32077083 2020

Variations for Idiopathic Scoliosis

ClinVar genetic disease variations for Idiopathic Scoliosis:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CELSR2 NM_001408.3(CELSR2):c.6859G>A (p.Val2287Ile)SNV Uncertain significance 397652 rs141489111 1:109812092-109812092 1:109269470-109269470

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

Pathways related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.91 MATN1 FBN2 FBN1 COL1A2
2 10.02 FBN2 FBN1

GO Terms for Idiopathic Scoliosis

Cellular components related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.46 MATN1 FBN2 FBN1 COL1A2
2 extracellular matrix GO:0031012 9.26 MATN1 FBN2 FBN1 COL1A2
3 microfibril GO:0001527 8.62 FBN2 FBN1

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.62 MATN1 FBN2 FBN1 COL1A2
2 anatomical structure morphogenesis GO:0009653 9.54 LBX1 FBN2 FBN1
3 skeletal system development GO:0001501 9.46 PAX1 FBN1 COL1A2 CHD7
4 embryonic eye morphogenesis GO:0048048 9.26 FBN2 FBN1
5 sequestering of TGFbeta in extracellular matrix GO:0035583 8.96 FBN2 FBN1
6 camera-type eye development GO:0043010 8.92 MTNR1B FBN2 FBN1 CHD7

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 8.96 FBN2 FBN1
2 extracellular matrix structural constituent GO:0005201 8.92 MATN1 FBN2 FBN1 COL1A2

Sources for Idiopathic Scoliosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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