MCID: IDP082
MIFTS: 8

Idiopathic Ventricular Fibrillation, Non Brugada Type

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Idiopathic Ventricular Fibrillation, Non Brugada Type

MalaCards integrated aliases for Idiopathic Ventricular Fibrillation, Non Brugada Type:

Name: Idiopathic Ventricular Fibrillation, Non Brugada Type 59
Familial Paroxysmal Ventricular Fibrillation, Non Brugada Type 59

Characteristics:

Orphanet epidemiological data:

59
idiopathic ventricular fibrillation, non brugada type
Inheritance: Autosomal dominant,Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 59 ORPHA228140
ICD10 via Orphanet 34 I49.0

Summaries for Idiopathic Ventricular Fibrillation, Non Brugada Type

MalaCards based summary : Idiopathic Ventricular Fibrillation, Non Brugada Type, also known as familial paroxysmal ventricular fibrillation, non brugada type, is related to paroxysmal ventricular fibrillation and cardiac arrest. An important gene associated with Idiopathic Ventricular Fibrillation, Non Brugada Type is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5).

Related Diseases for Idiopathic Ventricular Fibrillation, Non Brugada Type

Diseases related to Idiopathic Ventricular Fibrillation, Non Brugada Type via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 paroxysmal ventricular fibrillation 9.8 DPP6 SCN5A
2 cardiac arrest 9.7 DPP6 SCN5A

Symptoms & Phenotypes for Idiopathic Ventricular Fibrillation, Non Brugada Type

Drugs & Therapeutics for Idiopathic Ventricular Fibrillation, Non Brugada Type

Search Clinical Trials , NIH Clinical Center for Idiopathic Ventricular Fibrillation, Non Brugada Type

Genetic Tests for Idiopathic Ventricular Fibrillation, Non Brugada Type

Anatomical Context for Idiopathic Ventricular Fibrillation, Non Brugada Type

Publications for Idiopathic Ventricular Fibrillation, Non Brugada Type

Variations for Idiopathic Ventricular Fibrillation, Non Brugada Type

ClinVar genetic disease variations for Idiopathic Ventricular Fibrillation, Non Brugada Type:

6 (show top 50) (show all 212)
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh37 Chromosome 3, 38620907: 38620907
2 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh38 Chromosome 3, 38579416: 38579416
3 SCN5A NM_198056.2(SCN5A): c.1673A> G (p.His558Arg) single nucleotide variant Benign/Likely benign rs1805124 GRCh37 Chromosome 3, 38645420: 38645420
4 SCN5A NM_198056.2(SCN5A): c.1673A> G (p.His558Arg) single nucleotide variant Benign/Likely benign rs1805124 GRCh38 Chromosome 3, 38603929: 38603929
5 SCN5A NM_000335.4(SCN5A): c.2436+12G> A single nucleotide variant Conflicting interpretations of pathogenicity rs41312419 GRCh37 Chromosome 3, 38628879: 38628879
6 SCN5A NM_000335.4(SCN5A): c.2436+12G> A single nucleotide variant Conflicting interpretations of pathogenicity rs41312419 GRCh38 Chromosome 3, 38587388: 38587388
7 SCN5A NM_198056.2(SCN5A): c.4437+13C> T single nucleotide variant Conflicting interpretations of pathogenicity rs148598985 GRCh37 Chromosome 3, 38597919: 38597919
8 SCN5A NM_198056.2(SCN5A): c.4437+13C> T single nucleotide variant Conflicting interpretations of pathogenicity rs148598985 GRCh38 Chromosome 3, 38556428: 38556428
9 SCN5A NM_198056.2(SCN5A): c.100C> T (p.Arg34Cys) single nucleotide variant Benign/Likely benign rs6791924 GRCh37 Chromosome 3, 38674699: 38674699
10 SCN5A NM_198056.2(SCN5A): c.100C> T (p.Arg34Cys) single nucleotide variant Benign/Likely benign rs6791924 GRCh38 Chromosome 3, 38633208: 38633208
11 SCN5A NM_198056.2(SCN5A): c.1141-3C> A single nucleotide variant Benign/Likely benign rs41312433 GRCh37 Chromosome 3, 38647642: 38647642
12 SCN5A NM_198056.2(SCN5A): c.1141-3C> A single nucleotide variant Benign/Likely benign rs41312433 GRCh38 Chromosome 3, 38606151: 38606151
13 SCN5A NM_198056.2(SCN5A): c.1302C> T (p.Phe434=) single nucleotide variant Benign/Likely benign rs41313699 GRCh37 Chromosome 3, 38647478: 38647478
14 SCN5A NM_198056.2(SCN5A): c.1302C> T (p.Phe434=) single nucleotide variant Benign/Likely benign rs41313699 GRCh38 Chromosome 3, 38605987: 38605987
15 SCN5A NM_198056.2(SCN5A): c.1681C> T (p.Leu561=) single nucleotide variant Conflicting interpretations of pathogenicity rs45522138 GRCh37 Chromosome 3, 38645412: 38645412
16 SCN5A NM_198056.2(SCN5A): c.1681C> T (p.Leu561=) single nucleotide variant Conflicting interpretations of pathogenicity rs45522138 GRCh38 Chromosome 3, 38603921: 38603921
17 SCN5A NM_198056.2(SCN5A): c.2788-6C> T single nucleotide variant Benign/Likely benign rs41260344 GRCh37 Chromosome 3, 38622868: 38622868
18 SCN5A NM_198056.2(SCN5A): c.2788-6C> T single nucleotide variant Benign/Likely benign rs41260344 GRCh38 Chromosome 3, 38581377: 38581377
19 SCN5A NM_198056.2(SCN5A): c.3183A> G (p.Glu1061=) single nucleotide variant Benign/Likely benign rs7430407 GRCh37 Chromosome 3, 38622467: 38622467
20 SCN5A NM_198056.2(SCN5A): c.3183A> G (p.Glu1061=) single nucleotide variant Benign/Likely benign rs7430407 GRCh38 Chromosome 3, 38580976: 38580976
21 SCN5A NM_198056.2(SCN5A): c.3363G> A (p.Ala1121=) single nucleotide variant Conflicting interpretations of pathogenicity rs9858585 GRCh37 Chromosome 3, 38620852: 38620852
22 SCN5A NM_198056.2(SCN5A): c.3363G> A (p.Ala1121=) single nucleotide variant Conflicting interpretations of pathogenicity rs9858585 GRCh38 Chromosome 3, 38579361: 38579361
23 SCN5A NM_000335.4(SCN5A): c.4845C> T (p.Phe1615=) single nucleotide variant Benign/Likely benign rs41315495 GRCh37 Chromosome 3, 38593015: 38593015
24 SCN5A NM_000335.4(SCN5A): c.4845C> T (p.Phe1615=) single nucleotide variant Benign/Likely benign rs41315495 GRCh38 Chromosome 3, 38551524: 38551524
25 SCN5A NM_198056.2(SCN5A): c.5457T> C (p.Asp1819=) single nucleotide variant Benign/Likely benign rs1805126 GRCh37 Chromosome 3, 38592406: 38592406
26 SCN5A NM_198056.2(SCN5A): c.5457T> C (p.Asp1819=) single nucleotide variant Benign/Likely benign rs1805126 GRCh38 Chromosome 3, 38550915: 38550915
27 SCN5A NM_000335.4(SCN5A): c.5841C> T (p.Ile1947=) single nucleotide variant Benign/Likely benign rs13324293 GRCh37 Chromosome 3, 38592019: 38592019
28 SCN5A NM_000335.4(SCN5A): c.5841C> T (p.Ile1947=) single nucleotide variant Benign/Likely benign rs13324293 GRCh38 Chromosome 3, 38550528: 38550528
29 SCN5A NM_198056.2(SCN5A): c.87A> G (p.Ala29=) single nucleotide variant Benign/Likely benign rs6599230 GRCh37 Chromosome 3, 38674712: 38674712
30 SCN5A NM_198056.2(SCN5A): c.87A> G (p.Ala29=) single nucleotide variant Benign/Likely benign rs6599230 GRCh38 Chromosome 3, 38633221: 38633221
31 SCN5A NM_198056.2(SCN5A): c.1715C> A (p.Ala572Asp) single nucleotide variant Benign/Likely benign rs36210423 GRCh37 Chromosome 3, 38645378: 38645378
32 SCN5A NM_198056.2(SCN5A): c.1715C> A (p.Ala572Asp) single nucleotide variant Benign/Likely benign rs36210423 GRCh38 Chromosome 3, 38603887: 38603887
33 SCN5A NM_198056.2(SCN5A): c.21T> A (p.Pro7=) single nucleotide variant Conflicting interpretations of pathogenicity rs587781157 GRCh37 Chromosome 3, 38674778: 38674778
34 SCN5A NM_198056.2(SCN5A): c.21T> A (p.Pro7=) single nucleotide variant Conflicting interpretations of pathogenicity rs587781157 GRCh38 Chromosome 3, 38633287: 38633287
35 SCN5A NM_198056.2(SCN5A): c.1044C> T (p.Pro348=) single nucleotide variant Conflicting interpretations of pathogenicity rs370346797 GRCh37 Chromosome 3, 38648256: 38648256
36 SCN5A NM_198056.2(SCN5A): c.1044C> T (p.Pro348=) single nucleotide variant Conflicting interpretations of pathogenicity rs370346797 GRCh38 Chromosome 3, 38606765: 38606765
37 SCN5A NM_198056.2(SCN5A): c.1743G> A (p.Ser581=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313687 GRCh37 Chromosome 3, 38645350: 38645350
38 SCN5A NM_198056.2(SCN5A): c.1743G> A (p.Ser581=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313687 GRCh38 Chromosome 3, 38603859: 38603859
39 SCN5A NM_198056.2(SCN5A): c.2437-5C> A single nucleotide variant Conflicting interpretations of pathogenicity rs72549411 GRCh37 Chromosome 3, 38627537: 38627537
40 SCN5A NM_198056.2(SCN5A): c.2437-5C> A single nucleotide variant Conflicting interpretations of pathogenicity rs72549411 GRCh38 Chromosome 3, 38586046: 38586046
41 SCN5A NM_198056.2(SCN5A): c.3873G> A (p.Leu1291=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313033 GRCh37 Chromosome 3, 38603996: 38603996
42 SCN5A NM_198056.2(SCN5A): c.3873G> A (p.Leu1291=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313033 GRCh38 Chromosome 3, 38562505: 38562505
43 SCN5A NM_198056.2(SCN5A): c.1569T> A (p.Arg523=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313693 GRCh37 Chromosome 3, 38645524: 38645524
44 SCN5A NM_198056.2(SCN5A): c.1569T> A (p.Arg523=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313693 GRCh38 Chromosome 3, 38604033: 38604033
45 SCN5A NM_198056.2(SCN5A): c.6003C> T (p.Leu2001=) single nucleotide variant Conflicting interpretations of pathogenicity rs538707712 GRCh37 Chromosome 3, 38591860: 38591860
46 SCN5A NM_198056.2(SCN5A): c.6003C> T (p.Leu2001=) single nucleotide variant Conflicting interpretations of pathogenicity rs538707712 GRCh38 Chromosome 3, 38550369: 38550369
47 SCN5A NM_198056.2(SCN5A): c.4824C> T (p.Leu1608=) single nucleotide variant Conflicting interpretations of pathogenicity rs45437099 GRCh37 Chromosome 3, 38593039: 38593039
48 SCN5A NM_198056.2(SCN5A): c.4824C> T (p.Leu1608=) single nucleotide variant Conflicting interpretations of pathogenicity rs45437099 GRCh38 Chromosome 3, 38551548: 38551548
49 SCN5A NM_198056.2(SCN5A): c.1068T> C (p.Asp356=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313703 GRCh37 Chromosome 3, 38648232: 38648232
50 SCN5A NM_198056.2(SCN5A): c.1068T> C (p.Asp356=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313703 GRCh38 Chromosome 3, 38606741: 38606741

Expression for Idiopathic Ventricular Fibrillation, Non Brugada Type

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Pathways for Idiopathic Ventricular Fibrillation, Non Brugada Type

GO Terms for Idiopathic Ventricular Fibrillation, Non Brugada Type

Sources for Idiopathic Ventricular Fibrillation, Non Brugada Type

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