MCID: IDP082
MIFTS: 8

Idiopathic Ventricular Fibrillation, Non Brugada Type

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Idiopathic Ventricular Fibrillation, Non Brugada Type

MalaCards integrated aliases for Idiopathic Ventricular Fibrillation, Non Brugada Type:

Name: Idiopathic Ventricular Fibrillation, Non Brugada Type 59
Familial Paroxysmal Ventricular Fibrillation, Non Brugada Type 59

Characteristics:

Orphanet epidemiological data:

59
idiopathic ventricular fibrillation, non brugada type
Inheritance: Autosomal dominant,Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 59 ORPHA228140
ICD10 via Orphanet 34 I49.0

Summaries for Idiopathic Ventricular Fibrillation, Non Brugada Type

MalaCards based summary : Idiopathic Ventricular Fibrillation, Non Brugada Type, also known as familial paroxysmal ventricular fibrillation, non brugada type, is related to paroxysmal ventricular fibrillation and cardiac arrest. An important gene associated with Idiopathic Ventricular Fibrillation, Non Brugada Type is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5).

Related Diseases for Idiopathic Ventricular Fibrillation, Non Brugada Type

Diseases related to Idiopathic Ventricular Fibrillation, Non Brugada Type via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 paroxysmal ventricular fibrillation 9.2 DPP6 SCN5A
2 cardiac arrest 9.0 DPP6 SCN5A

Symptoms & Phenotypes for Idiopathic Ventricular Fibrillation, Non Brugada Type

Drugs & Therapeutics for Idiopathic Ventricular Fibrillation, Non Brugada Type

Search Clinical Trials , NIH Clinical Center for Idiopathic Ventricular Fibrillation, Non Brugada Type

Genetic Tests for Idiopathic Ventricular Fibrillation, Non Brugada Type

Anatomical Context for Idiopathic Ventricular Fibrillation, Non Brugada Type

Publications for Idiopathic Ventricular Fibrillation, Non Brugada Type

Variations for Idiopathic Ventricular Fibrillation, Non Brugada Type

ClinVar genetic disease variations for Idiopathic Ventricular Fibrillation, Non Brugada Type:

6
(show top 50) (show all 172)
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh37 Chromosome 3, 38620907: 38620907
2 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh38 Chromosome 3, 38579416: 38579416
3 SCN5A NM_198056.2(SCN5A): c.1569T> A (p.Arg523=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313693 GRCh37 Chromosome 3, 38645524: 38645524
4 SCN5A NM_198056.2(SCN5A): c.1569T> A (p.Arg523=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313693 GRCh38 Chromosome 3, 38604033: 38604033
5 SCN5A NM_198056.2(SCN5A): c.6003C> T (p.Leu2001=) single nucleotide variant Conflicting interpretations of pathogenicity rs538707712 GRCh37 Chromosome 3, 38591860: 38591860
6 SCN5A NM_198056.2(SCN5A): c.6003C> T (p.Leu2001=) single nucleotide variant Conflicting interpretations of pathogenicity rs538707712 GRCh38 Chromosome 3, 38550369: 38550369
7 SCN5A NM_198056.2(SCN5A): c.4824C> T (p.Leu1608=) single nucleotide variant Conflicting interpretations of pathogenicity rs45437099 GRCh37 Chromosome 3, 38593039: 38593039
8 SCN5A NM_198056.2(SCN5A): c.4824C> T (p.Leu1608=) single nucleotide variant Conflicting interpretations of pathogenicity rs45437099 GRCh38 Chromosome 3, 38551548: 38551548
9 SCN5A NM_198056.2(SCN5A): c.1068T> C (p.Asp356=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313703 GRCh37 Chromosome 3, 38648232: 38648232
10 SCN5A NM_198056.2(SCN5A): c.1068T> C (p.Asp356=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313703 GRCh38 Chromosome 3, 38606741: 38606741
11 SCN5A NM_001099404.1(SCN5A): c.1598G> A (p.Arg533His) single nucleotide variant Uncertain significance rs146848219 GRCh37 Chromosome 3, 38645495: 38645495
12 SCN5A NM_001099404.1(SCN5A): c.1598G> A (p.Arg533His) single nucleotide variant Uncertain significance rs146848219 GRCh38 Chromosome 3, 38604004: 38604004
13 SCN5A NM_198056.2(SCN5A): c.4109A> G (p.Asp1370Gly) single nucleotide variant Uncertain significance rs775485359 GRCh37 Chromosome 3, 38601774: 38601774
14 SCN5A NM_198056.2(SCN5A): c.4109A> G (p.Asp1370Gly) single nucleotide variant Uncertain significance rs775485359 GRCh38 Chromosome 3, 38560283: 38560283
15 SCN5A NM_198056.2(SCN5A): c.2956C> T (p.Arg986Trp) single nucleotide variant Uncertain significance rs561547165 GRCh37 Chromosome 3, 38622694: 38622694
16 SCN5A NM_198056.2(SCN5A): c.2956C> T (p.Arg986Trp) single nucleotide variant Uncertain significance rs561547165 GRCh38 Chromosome 3, 38581203: 38581203
17 SCN5A NM_198056.2(SCN5A): c.787G> A (p.Val263Ile) single nucleotide variant Uncertain significance rs752824646 GRCh37 Chromosome 3, 38651372: 38651372
18 SCN5A NM_198056.2(SCN5A): c.787G> A (p.Val263Ile) single nucleotide variant Uncertain significance rs752824646 GRCh38 Chromosome 3, 38609881: 38609881
19 SCN5A NM_001099404.1(SCN5A): c.4267G> A (p.Asp1423Asn) single nucleotide variant Uncertain significance rs746291609 GRCh37 Chromosome 3, 38598754: 38598754
20 SCN5A NM_001099404.1(SCN5A): c.4267G> A (p.Asp1423Asn) single nucleotide variant Uncertain significance rs746291609 GRCh38 Chromosome 3, 38557263: 38557263
21 SCN5A NM_198056.2(SCN5A): c.5607C> T (p.Asp1869=) single nucleotide variant Conflicting interpretations of pathogenicity rs560476223 GRCh38 Chromosome 3, 38550765: 38550765
22 SCN5A NM_198056.2(SCN5A): c.5607C> T (p.Asp1869=) single nucleotide variant Conflicting interpretations of pathogenicity rs560476223 GRCh37 Chromosome 3, 38592256: 38592256
23 SCN5A NM_198056.2(SCN5A): c.5454C> T (p.Ala1818=) single nucleotide variant Conflicting interpretations of pathogenicity rs370114378 GRCh38 Chromosome 3, 38550918: 38550918
24 SCN5A NM_198056.2(SCN5A): c.5454C> T (p.Ala1818=) single nucleotide variant Conflicting interpretations of pathogenicity rs370114378 GRCh37 Chromosome 3, 38592409: 38592409
25 SCN5A NM_198056.2(SCN5A): c.3542T> C (p.Val1181Ala) single nucleotide variant Uncertain significance rs376965389 GRCh37 Chromosome 3, 38616912: 38616912
26 SCN5A NM_198056.2(SCN5A): c.3542T> C (p.Val1181Ala) single nucleotide variant Uncertain significance rs376965389 GRCh38 Chromosome 3, 38575421: 38575421
27 SCN5A NM_198056.2(SCN5A) insertion Likely benign rs45592631 GRCh38 Chromosome 3, 38548175: 38548176
28 SCN5A NM_198056.2(SCN5A) insertion Likely benign rs45592631 GRCh37 Chromosome 3, 38589666: 38589667
29 SCN5A NM_198056.2(SCN5A): c.*1701G> T single nucleotide variant Uncertain significance rs886058441 GRCh38 Chromosome 3, 38548620: 38548620
30 SCN5A NM_198056.2(SCN5A): c.*1701G> T single nucleotide variant Uncertain significance rs886058441 GRCh37 Chromosome 3, 38590111: 38590111
31 SCN5A NM_198056.2(SCN5A): c.*1602G> T single nucleotide variant Uncertain significance rs886058444 GRCh38 Chromosome 3, 38548719: 38548719
32 SCN5A NM_198056.2(SCN5A): c.*1602G> T single nucleotide variant Uncertain significance rs886058444 GRCh37 Chromosome 3, 38590210: 38590210
33 SCN5A NM_198056.2(SCN5A): c.*1537T> C single nucleotide variant Likely benign rs41315485 GRCh38 Chromosome 3, 38548784: 38548784
34 SCN5A NM_198056.2(SCN5A): c.*1537T> C single nucleotide variant Likely benign rs41315485 GRCh37 Chromosome 3, 38590275: 38590275
35 SCN5A NM_198056.2(SCN5A): c.*1165C> T single nucleotide variant Likely benign rs41313017 GRCh38 Chromosome 3, 38549156: 38549156
36 SCN5A NM_198056.2(SCN5A): c.*1165C> T single nucleotide variant Likely benign rs41313017 GRCh37 Chromosome 3, 38590647: 38590647
37 SCN5A NM_198056.2(SCN5A): c.*1164G> T single nucleotide variant Uncertain significance rs41315489 GRCh38 Chromosome 3, 38549157: 38549157
38 SCN5A NM_198056.2(SCN5A): c.*1164G> T single nucleotide variant Uncertain significance rs41315489 GRCh37 Chromosome 3, 38590648: 38590648
39 SCN5A NM_198056.2(SCN5A): c.*980C> A single nucleotide variant Uncertain significance rs886058449 GRCh38 Chromosome 3, 38549341: 38549341
40 SCN5A NM_198056.2(SCN5A): c.*980C> A single nucleotide variant Uncertain significance rs886058449 GRCh37 Chromosome 3, 38590832: 38590832
41 SCN5A NM_198056.2(SCN5A): c.*963C> T single nucleotide variant Likely benign rs4073796 GRCh38 Chromosome 3, 38549358: 38549358
42 SCN5A NM_198056.2(SCN5A): c.*963C> T single nucleotide variant Likely benign rs4073796 GRCh37 Chromosome 3, 38590849: 38590849
43 SCN5A NM_198056.2(SCN5A): c.*889C> A single nucleotide variant Uncertain significance rs546849670 GRCh38 Chromosome 3, 38549432: 38549432
44 SCN5A NM_198056.2(SCN5A): c.*889C> A single nucleotide variant Uncertain significance rs546849670 GRCh37 Chromosome 3, 38590923: 38590923
45 SCN5A NM_198056.2(SCN5A): c.*382T> C single nucleotide variant Uncertain significance rs45459402 GRCh37 Chromosome 3, 38591430: 38591430
46 SCN5A NM_198056.2(SCN5A): c.*382T> C single nucleotide variant Uncertain significance rs45459402 GRCh38 Chromosome 3, 38549939: 38549939
47 SCN5A NM_198056.2(SCN5A): c.*290G> A single nucleotide variant Uncertain significance rs886058457 GRCh37 Chromosome 3, 38591522: 38591522
48 SCN5A NM_198056.2(SCN5A): c.*290G> A single nucleotide variant Uncertain significance rs886058457 GRCh38 Chromosome 3, 38550031: 38550031
49 SCN5A NM_198056.2(SCN5A): c.*204T> C single nucleotide variant Uncertain significance rs147795595 GRCh38 Chromosome 3, 38550117: 38550117
50 SCN5A NM_198056.2(SCN5A): c.*204T> C single nucleotide variant Uncertain significance rs147795595 GRCh37 Chromosome 3, 38591608: 38591608

Expression for Idiopathic Ventricular Fibrillation, Non Brugada Type

Search GEO for disease gene expression data for Idiopathic Ventricular Fibrillation, Non Brugada Type.

Pathways for Idiopathic Ventricular Fibrillation, Non Brugada Type

GO Terms for Idiopathic Ventricular Fibrillation, Non Brugada Type

Sources for Idiopathic Ventricular Fibrillation, Non Brugada Type

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