IGAN2
MCID: IGN002
MIFTS: 19

Iga Nephropathy 2 (IGAN2)

Categories: Genetic diseases, Immune diseases, Nephrological diseases

Aliases & Classifications for Iga Nephropathy 2

MalaCards integrated aliases for Iga Nephropathy 2:

Name: Iga Nephropathy 2 57
Iga Nephropathy, Susceptibility to, 2 57 13
Igan2 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
?autosomal dominant

Miscellaneous:
histologic features overlap with henoch-schonlein purpura (hspn)
incidence 5-50 per million (children) and 10-40 per million (adults)


HPO:

31
iga nephropathy 2:
Inheritance autosomal dominant inheritance
Onset and clinical course incomplete penetrance


Classifications:



External Ids:

OMIM® 57 613944
OMIM Phenotypic Series 57 PS161950
MedGen 41 C3151378

Summaries for Iga Nephropathy 2

MalaCards based summary : Iga Nephropathy 2, also known as iga nephropathy, susceptibility to, 2, is related to iga nephropathy 3 and proteinuria, chronic benign. An important gene associated with Iga Nephropathy 2 is IGAN2 (IgA Nephropathy, Susceptibility To, 2). Affiliated tissues include kidney, and related phenotypes are arthralgia and hypertension

More information from OMIM: 613944 PS161950

Related Diseases for Iga Nephropathy 2

Diseases in the Iga Nephropathy 1 family:

Iga Nephropathy 2 Iga Nephropathy 3

Diseases related to Iga Nephropathy 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 iga nephropathy 3 9.9
2 proteinuria, chronic benign 9.9
3 iga glomerulonephritis 9.9

Symptoms & Phenotypes for Iga Nephropathy 2

Human phenotypes related to Iga Nephropathy 2:

31 (show all 7)
# Description HPO Frequency HPO Source Accession
1 arthralgia 31 occasional (7.5%) HP:0002829
2 hypertension 31 HP:0000822
3 proteinuria 31 HP:0000093
4 hematuria 31 HP:0000790
5 stage 5 chronic kidney disease 31 HP:0003774
6 nephritis 31 HP:0000123
7 iga deposition in the glomerulus 31 HP:0000794

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Cardiovascular Vascular:
hypertension

Laboratory Abnormalities:
proteinuria
hematuria, macroscopic and microscopic

Immunology:
serum circulating immune complexes contain galactose-deficient iga1

Genitourinary Kidneys:
proteinuria
hematuria, microscopic
hematuria, macroscopic (seen in children and young adults coincident with mucosal infection)
galactose-deficient iga1 deposits in the glomerular mesangium, with or without igm and igg
glomerular crescents (rare), seen on biopsy
more
Skeletal:
arthralgia (in some patients)

Clinical features from OMIM®:

613944 (Updated 05-Apr-2021)

Drugs & Therapeutics for Iga Nephropathy 2

Search Clinical Trials , NIH Clinical Center for Iga Nephropathy 2

Genetic Tests for Iga Nephropathy 2

Anatomical Context for Iga Nephropathy 2

MalaCards organs/tissues related to Iga Nephropathy 2:

40
Kidney

Publications for Iga Nephropathy 2

Articles related to Iga Nephropathy 2:

(show all 18)
# Title Authors PMID Year
1
Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36. 57
17634434 2007
2
Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci. 57
17186473 2006
3
[Four cases of nephrotic syndrome with TRPC6 gene variations and literature review]. 61
33657698 2021
4
B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease. 61
32479988 2020
5
Study of Glomerulopathy in Donors after Kidney Transplantation. 61
33254170 2020
6
Study of the variables associated with local complement activation in IgA nephropathy. 61
28495395 2017
7
Chronic kidney disease associated with perinatal HIV infection in children and adolescents. 61
22366874 2012
8
Search for genetic association between IgA nephropathy and candidate genes selected by function or by gene mapping at loci IGAN2 and IGAN3. 61
22131235 2012
9
Acquired glomerular lesions in patients with Down syndrome. 61
21733549 2012
10
Ten-year retrospective analysis of incisional herniorrhaphy following renal transplantation. 61
21242441 2011
11
The spectrum of acute renal failure in IgA nephropathy. 61
20446779 2010
12
Clinical trial to evaluate omega-3 fatty acids and alternate day prednisone in patients with IgA nephropathy: report from the Southwest Pediatric Nephrology Study Group. 61
17699247 2006
13
[Clinical and pathological characteristics in patients with clinically presumed hypertensive nephrosclerosis]. 61
16776947 2006
14
Occurrence of hyaline droplets in renal biopsy specimens: an ultrastructural study. 61
16158182 2005
15
Use of fish oil to treat patients with immunoglobulin a nephropathy. 61
10618000 2000
16
Effects of methylprednisolone and cyclophosphamide pulse therapy on renal infiltrating cells in patients with crescentic glomerulonephritis. 61
9594342 1997
17
Reversible acute renal failure from gross haematuria due to glomerulonephritis: not only in IgA nephropathy and not associated with intratubular obstruction. 61
7566573 1995
18
Captopril, an angiotensin I-converting enzyme inhibitor, decreases proteinuria in hypertensive patients with renal diseases. 61
2651951 1989

Variations for Iga Nephropathy 2

Expression for Iga Nephropathy 2

Search GEO for disease gene expression data for Iga Nephropathy 2.

Pathways for Iga Nephropathy 2

GO Terms for Iga Nephropathy 2

Sources for Iga Nephropathy 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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