MCID: IGN002
MIFTS: 16

Iga Nephropathy 2

Categories: Nephrological diseases, Genetic diseases

Aliases & Classifications for Iga Nephropathy 2

MalaCards integrated aliases for Iga Nephropathy 2:

Name: Iga Nephropathy 2 57
Iga Nephropathy, Susceptibility to, 2 57 13
Igan2 57

Characteristics:

OMIM:

57
Inheritance:
?autosomal dominant

Miscellaneous:
histologic features overlap with henoch-schonlein purpura (hspn)
incidence 5-50 per million (children) and 10-40 per million (adults)


Classifications:



External Ids:

OMIM 57 613944
MedGen 42 C3151378

Summaries for Iga Nephropathy 2

MalaCards based summary : Iga Nephropathy 2, also known as iga nephropathy, susceptibility to, 2, is related to iga glomerulonephritis. An important gene associated with Iga Nephropathy 2 is IGAN2 (IgA Nephropathy, Susceptibility To, 2). Affiliated tissues include kidney, and related phenotypes are proteinuria and iga deposition in the glomerulus

Description from OMIM: 613944

Related Diseases for Iga Nephropathy 2

Diseases in the Iga Nephropathy 1 family:

Iga Nephropathy 2 Iga Nephropathy 3

Diseases related to Iga Nephropathy 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 iga glomerulonephritis 11.3

Symptoms & Phenotypes for Iga Nephropathy 2

Symptoms via clinical synopsis from OMIM:

57
Cardiovascular Vascular:
hypertension

Skeletal:
arthralgia (in some patients)

Laboratory Abnormalities:
hematuria, macroscopic and microscopic
proteinuria

Genitourinary Kidneys:
hematuria, macroscopic (seen in children and young adults coincident with mucosal infection)
proteinuria
galactose-deficient iga1 deposits in the glomerular mesangium, with or without igm and igg
hematuria, microscopic
glomerular crescents (rare), seen on biopsy
more
Immunology:
serum circulating immune complexes contain galactose-deficient iga1


Clinical features from OMIM:

613944

Human phenotypes related to Iga Nephropathy 2:

32
# Description HPO Frequency HPO Source Accession
1 proteinuria 32 HP:0000093
2 iga deposition in the glomerulus 32 HP:0000794
3 hypertension 32 HP:0000822
4 arthralgia 32 occasional (7.5%) HP:0002829
5 stage 5 chronic kidney disease 32 HP:0003774

Drugs & Therapeutics for Iga Nephropathy 2

Search Clinical Trials , NIH Clinical Center for Iga Nephropathy 2

Genetic Tests for Iga Nephropathy 2

Anatomical Context for Iga Nephropathy 2

MalaCards organs/tissues related to Iga Nephropathy 2:

41
Kidney

Publications for Iga Nephropathy 2

Variations for Iga Nephropathy 2

Expression for Iga Nephropathy 2

Search GEO for disease gene expression data for Iga Nephropathy 2.

Pathways for Iga Nephropathy 2

GO Terms for Iga Nephropathy 2

Sources for Iga Nephropathy 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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