MCID: IGP001
MIFTS: 27

Iga Pemphigus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Iga Pemphigus

MalaCards integrated aliases for Iga Pemphigus:

Name: Iga Pemphigus 59 17

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA555905

Summaries for Iga Pemphigus

MalaCards based summary : Iga Pemphigus is related to herpetiform pemphigus and pemphigus vegetans. An important gene associated with Iga Pemphigus is CD79A (CD79a Molecule), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, neutrophil and lung, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and integument

Wikipedia : 75 IgA pemphigus is a subtype of pemphigus with two distinct... more...

Related Diseases for Iga Pemphigus

Diseases related to Iga Pemphigus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 herpetiform pemphigus 30.1 DSG3 DSG1
2 pemphigus vegetans 29.3 PPL DSG1 DSC3
3 thymoma 29.0 PPL EVPL
4 pemphigus 29.0 PPL EVPL DSG3 DSG1 DSC3 DSC1
5 subcorneal pustular dermatosis 28.9 PPL EVPL DSG3 DSG1 DSC3 DSC1
6 bronchiolitis obliterans 28.9 PPL EVPL
7 pemphigus foliaceus 28.8 PPL EVPL DSG3 DSG1
8 skin disease 28.6 DSG3 DSG1 DSC3 DSC1 CD79A
9 bullous pemphigoid 27.4 PPL EVPL DSG3 DSG1 CD79A
10 paraneoplastic pemphigus 27.1 PPL EVPL DSG3 DSG1 DSC3 DSC1
11 pemphigus vulgaris, familial 10.3
12 myeloma, multiple 10.2
13 autoimmune disease 10.2
14 ulcerative colitis 10.2
15 inflammatory bowel disease 10.1
16 dermatitis herpetiformis, familial 10.0
17 colitis 10.0
18 dermatitis herpetiformis 10.0
19 linear iga disease 10.0
20 thymoma, familial 9.9
21 wilson disease 9.9
22 erythema multiforme 9.9
23 exanthem 9.9
24 diffuse large b-cell lymphoma 9.9
25 hypopyon 9.9
26 respiratory failure 9.9
27 urethritis 9.9
28 bronchiolitis 9.9
29 pustulosis of palm and sole 9.9
30 b-cell lymphoma 9.9
31 monoclonal gammopathy of uncertain significance 9.9
32 impetigo 9.9
33 myeloid leukemia 9.9
34 psoriasis 9.9
35 pustular psoriasis 9.9
36 bullous impetigo 9.9 DSG3 DSG1
37 follicular dendritic cell sarcoma 9.5 PPL EVPL
38 hypotrichosis 9.4 DSG1 DSC3
39 autoimmune disease of skin and connective tissue 9.2 PPL EVPL DSG1
40 cellulitis 8.9 PPL DSG3 DSG1 DSC3
41 bullous skin disease 8.2 PPL EVPL DSG3 DSG1 DSC3

Graphical network of the top 20 diseases related to Iga Pemphigus:



Diseases related to Iga Pemphigus

Symptoms & Phenotypes for Iga Pemphigus

GenomeRNAi Phenotypes related to Iga Pemphigus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 CD79A DSC3 DSG1

MGI Mouse Phenotypes related to Iga Pemphigus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 DSC1 DSC3 DSG1 DSG3 EVPL

Drugs & Therapeutics for Iga Pemphigus

Search Clinical Trials , NIH Clinical Center for Iga Pemphigus

Genetic Tests for Iga Pemphigus

Anatomical Context for Iga Pemphigus

MalaCards organs/tissues related to Iga Pemphigus:

41
Skin, Neutrophil, Lung, Testes, T Cells, Colon, B Cells

Publications for Iga Pemphigus

Articles related to Iga Pemphigus:

(show top 50) (show all 134)
# Title Authors PMID Year
1
IgG/IgA pemphigus in a patient with a history of pemphigus vulgaris: An example of epitope spreading? 38
30681733 2019
2
IgG/IgA pemphigus: Report of a rare subtype of pemphigus. 38
30246321 2019
3
[IGA Pemphigus]. 38
30926207 2019
4
Systemic retinoids for treatment of recalcitrant IgA pemphigus. 38
30227880 2018
5
Imatinib-induced IgA Pemphigus: Subcorneal Pustular Dermatosis Type. 38
30258803 2018
6
Oral pemphigus. 38
29512980 2018
7
Pemphigus group: overview, epidemiology, mortality, and comorbidities. 38
29479654 2018
8
Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis. 38
28653439 2018
9
Clinical and Immunological Study of 30 Cases With Both IgG and IgA Anti-Keratinocyte Cell Surface Autoantibodies Toward the Definition of Intercellular IgG/IgA Dermatosis. 38
29867971 2018
10
A case of IgA pemphigus foliaceus with high scores on drug-induced lymphocyte stimulation tests secondary to various drugs. 38
29165304 2017
11
Anti-Desmoglein 1 IgG/IgA-Pemphigus in Verbindung mit einem Thymom. 38
29106026 2017
12
Anti-desmoglein 1 IgG/IgA pemphigus associated with thymoma. 38
29030953 2017
13
IgA pemphigus: lumping or splitting? 38
28466500 2017
14
Crusted impetigo-like lesion on the face: a case of IgG/IgA pemphigus. 38
27879012 2017
15
Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein. 38
27516004 2017
16
Utility of immunofluorescence in dermatology. 38
28217464 2017
17
Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University. 38
27258999 2017
18
Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress. 38
27349653 2016
19
Discrepancies among clinical, histological and immunological findings in IgA pemphigus: a case report and literature survey. 38
28035228 2016
20
IgA pemphigus showing IgA antibodies to desmoglein 1 and 3. 38
27867744 2016
21
Generalized pustular psoriasis induced by systemic steroid dose reduction. 38
27828647 2016
22
Bullous Pemphigoid with Lymphocytic Colitis: A Case Report and Short Literature Review. 38
27469343 2016
23
IgG/IgA pemphigus representing pemphigus vegetans caused by low titres of IgG and IgA antibodies to desmoglein 3 and IgA antibodies to desmocollin 3. 38
25865168 2016
24
Juvenile IgA pemphigus: A case report and review of literature. 38
27279313 2016
25
Successful treatment of Wilson disease-associated IgA pemphigus with IVIG. 38
25764440 2016
26
A Clinicopathological Study of Pemphigus in Eastern India with Special Reference to Direct Immunofluorescence. 38
27293249 2016
27
Clinicopathologic features of IgG/IgA pemphigus in comparison with classic (IgG) and IgA pemphigus. 38
26566588 2016
28
Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis. 38
27023083 2016
29
Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone. 38
26219735 2016
30
Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins. 38
26758100 2016
31
Immunobullous disease and ulcerative colitis: a case series of six patients. 38
25913891 2015
32
Epidermal polymeric immunoglobulin receptors: leads from intraepidermal neutrophilic IgA dermatosis-type IgA pemphigus. 38
25496384 2015
33
Antidesmocollin 1 autoantibody negative subcorneal pustular dermatosis-type IgA pemphigus associated with multiple myeloma. 38
24980095 2015
34
IgG/IgA pemphigus. 38
24752215 2014
35
Immunofluorescence testing in the diagnosis of autoimmune blistering diseases: overview of 10-year experience. 38
25387492 2014
36
The expanding spectrum of IgA pemphigus: a case report and review of the literature. 38
24601812 2014
37
Management of a pemphigus with IgA and IgG antibodies and coexistent lung cancer. 38
24754245 2014
38
IgG/IgA pemphigus recognizing desmogleins 1 and 3 in a patient with Sjögren's syndrome. 38
25167567 2014
39
Peripheral T-cell lymphoma complicated by immunoglobulin A pemphigus: A case report and literature review. 38
24959219 2014
40
Overlap of IgA pemphigus and linear IgA dermatosis in a patient with ulcerative colitis: a mere coincidence? 38
23824334 2014
41
Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus. 38
24626654 2014
42
IgG/IgA pemphigus reactive with desmoglein 1 with additional undetermined reactivity with epidermal basement membrane zone. 38
24448124 2014
43
IgA pemphigus: case series with emphasis on therapeutic response. 38
24355273 2014
44
[Efficacy of acitretin in IgA pemphigus]. 38
24315226 2013
45
IgA pemphigus with paraneoplastic pemphigus-like clinical features showing IgA antibodies to desmoglein 1/3 and desmocollin 3, and IgG and IgA antibodies to the basement membrane zone. 38
23517469 2013
46
IgA pemphigus with non-pustular erythematous lesions and IgA antibodies to desmocollins 1 and 2. 38
23797684 2013
47
Pemphigus vegetans variant of IgA pemphigus, a variant of IgA pemphigus and other autoimmune blistering disorders. 38
23221471 2013
48
IgA pemphigus associated with diffuse large B-cell lymphoma showing unique reactivity with desmocollins: unusual clinical and histopathological features. 38
22757612 2013
49
Pemphigus foliaceus masquerading as IgA pemphigus and responding to dapsone. 38
23248372 2012
50
Pathogenesis of epidermolysis bullosa acquisita, an autoimmune subepidermal bullous disease. 38
22692770 2012

Variations for Iga Pemphigus

Expression for Iga Pemphigus

Search GEO for disease gene expression data for Iga Pemphigus.

Pathways for Iga Pemphigus

Pathways related to Iga Pemphigus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 PPL EVPL DSG3 DSG1 DSC3 DSC1
2
Show member pathways
11.56 PPL EVPL DSG3 DSG1 DSC3 DSC1
3
Show member pathways
11.32 DSG3 DSG1
4
Show member pathways
11.19 PPL EVPL

GO Terms for Iga Pemphigus

Cellular components related to Iga Pemphigus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.87 PPL EVPL DSG3 DSG1 DSC3 DSC1
2 plasma membrane GO:0005886 9.85 PPL DSG3 DSG1 DSC3 DSC1 CD79A
3 cell junction GO:0030054 9.63 PPL EVPL DSG3 DSG1 DSC3 DSC1
4 cornified envelope GO:0001533 9.43 PPL EVPL DSG3 DSG1 DSC3 DSC1
5 ficolin-1-rich granule membrane GO:0101003 9.26 DSG1 DSC1
6 desmosome GO:0030057 9.1 PPL EVPL DSG3 DSG1 DSC3 DSC1

Biological processes related to Iga Pemphigus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.56 DSG3 DSG1 DSC3 DSC1
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.46 DSG3 DSG1 DSC3 DSC1
3 keratinization GO:0031424 9.43 PPL EVPL DSG3 DSG1 DSC3 DSC1
4 wound healing GO:0042060 9.37 PPL EVPL
5 intermediate filament cytoskeleton organization GO:0045104 9.32 PPL EVPL
6 cornification GO:0070268 9.1 PPL EVPL DSG3 DSG1 DSC3 DSC1

Molecular functions related to Iga Pemphigus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 8.92 DSG3 DSG1 DSC3 DSC1

Sources for Iga Pemphigus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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