IGER
MCID: IGR001
MIFTS: 57

Ige Responsiveness, Atopic (IGER)

Categories: Genetic diseases, Immune diseases
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Aliases & Classifications for Ige Responsiveness, Atopic

MalaCards integrated aliases for Ige Responsiveness, Atopic:

Name: Ige Responsiveness, Atopic 57 28 5 71
Atopy 57 73 12 53 16 71
Atopy, Susceptibility to 57 5
Ige, Elevated Level of 57 5
Ige Response Underlying Allergic Asthma and Rhinitis 57
Immunoglobulin E, Basic Level of, in Serum 57
Immediate Hypersensitivity 71
Atopic Hypersensitivity 73
Ige, Level of 57
Iger 57
Igel 57

Characteristics:


Inheritance:

Autosomal dominant 57

Classifications:



External Ids:

OMIM® 57 147050
MeSH 43 D006969
UMLS 71 C0020523 C0392707 C1840253

Summaries for Ige Responsiveness, Atopic

UniProtKB/Swiss-Prot: 73 A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.

MalaCards based summary: Ige Responsiveness, Atopic, also known as atopy, is related to chronic rhinitis and churg-strauss syndrome. An important gene associated with Ige Responsiveness, Atopic is IL21R (Interleukin 21 Receptor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Histamine and Desloratadine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lung, and related phenotypes are asthma and eczema

More information from OMIM: 147050

Related Diseases for Ige Responsiveness, Atopic

Diseases related to Ige Responsiveness, Atopic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 683)
# Related Disease Score Top Affiliating Genes
1 chronic rhinitis 31.2 RNASE3 IL5 IL4 IL13
2 churg-strauss syndrome 31.0 RNASE3 IL5 IL10
3 respiratory syncytial virus infectious disease 30.8 IL5 IL13
4 irritant dermatitis 30.3 IL4 IL13
5 alopecia areata 30.3 IL4 IL13 IFNG
6 drug allergy 30.3 IL5 IL4 IL13 IGHE
7 latex allergy 30.2 IL13 IGHE
8 occupational asthma 30.1 RNASE3 IL5 IL4 IL13
9 neurodermatitis 30.0 IL4 IL13
10 scabies 30.0 IL5 IL4 IL13
11 ascaris lumbricoides infection 30.0 IL5 IL4 IL13 IL10
12 eosinophilic gastroenteritis 30.0 RNASE3 IL5 IL4 IL13 IGHE
13 viral infectious disease 30.0 IL4 IL13 IL10 IFNG
14 exanthem 30.0 IL4 IL10 IFNG
15 hepatitis a 29.9 IL4 IL10 IFNG
16 exercise-induced bronchoconstriction 29.9 RNASE3 IL5 IL4 IL13 IGHE
17 chronic spontaneous urticaria 29.9 IL5 IL4 IL13
18 chronic urticaria 29.9 RNASE3 IL5 IGHE
19 common cold 29.8 RNASE3 IL5 IL4 IL13 IL10
20 pollen allergy 29.8 IL5 IL4 IL13 IL10
21 rhinitis 29.8 RNASE3 IL5 IL4R IL4 IL13 IL10
22 adenoid hypertrophy 29.8 IL5 IL4 IL10
23 enterocolitis 29.8 IL10 CD14
24 primary cutaneous t-cell non-hodgkin lymphoma 29.8 IL5 IL4 IFNG
25 eosinophilic gastritis 29.7 IL5 IL13
26 aspergillosis 29.7 IL5 IL4 IL10 IFNG
27 anisakiasis 29.7 RNASE3 IGHE
28 vernal keratoconjunctivitis 29.7 RNASE3 IL4 IL13 IGES
29 mycosis fungoides 29.6 IL5 IL4 IFNG
30 bronchitis 29.6 RNASE3 IL5 IL4 IL13 IL10 IGHE
31 diphtheria 29.6 IL5 IL4 IL13 IFNG
32 cough variant asthma 29.6 RNASE3 IL5 IL4 IL13
33 vasomotor rhinitis 29.6 RNASE3 IL5 IL4 IL13
34 toxoplasmosis 29.6 IL5 IL4 IL10 IFNG
35 autoimmune disease 29.6 IL5 IL4 IL13 IL10 IFNG
36 esophagitis, eosinophilic, 1 29.6 STAT6 SPINK5 RNASE3 IL5 IL4 IL13
37 keratoconjunctivitis 29.5 RNASE3 IL5 IL4 IL13 IFNG
38 lipoid nephrosis 29.5 IL4R IL13 IL10
39 intrinsic asthma 29.5 RNASE3 IL5 IL4 IL13 IL10 IGHE
40 type 1 diabetes mellitus 29.5 PLA2G7 IL4 IL10 IFNG
41 cellulitis 29.5 RNASE3 IL5 IGES
42 chickenpox 29.5 IL4 IL10 IFNG
43 allergic bronchopulmonary aspergillosis 29.5 IL5 IL4 IL13 IGHE IGES IFNG
44 angioedema 29.4 IL5 IL10 IGHE
45 thyroiditis 29.4 IL4 IL10 IFNG
46 dermatitis 29.4 SPINK5 RNASE3 IL5 IL4R IL4 IL13
47 uveitis 29.4 IL4 IL10 IFNG
48 igg4-related disease 29.4 IL5 IL4 IL13 IL10
49 filarial elephantiasis 29.4 IL5 IL4 IL13 IL10
50 chlamydia 29.4 IL5 IL4 IL10 IFNG

Graphical network of the top 20 diseases related to Ige Responsiveness, Atopic:



Diseases related to Ige Responsiveness, Atopic

Symptoms & Phenotypes for Ige Responsiveness, Atopic

Human phenotypes related to Ige Responsiveness, Atopic:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 asthma 30 HP:0002099
2 eczema 30 HP:0000964
3 allergic rhinitis 30 HP:0003193
4 increased circulating ige level 30 HP:0003212

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Pulmonary:
asthma
hay fever

Immunology:
atopic hypersensitivity

Skin:
eczema

Lab:
ige level control

Clinical features from OMIM®:

147050 (Updated 08-Dec-2022)

MGI Mouse Phenotypes related to Ige Responsiveness, Atopic:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.1 CD14 IFNG IGHE IL10 IL13 IL21R
2 respiratory system MP:0005388 9.81 CD14 IFNG IL10 IL13 IL4 IL4R
3 hematopoietic system MP:0005397 9.77 CD14 IFNG IGHE IL10 IL13 IL21R
4 integument MP:0010771 9.23 CSN1S1 IFNG IL10 IL13 IL4 IL4R

Drugs & Therapeutics for Ige Responsiveness, Atopic

Drugs for Ige Responsiveness, Atopic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Desloratadine Approved, Investigational Phase 3 100643-71-8 124087
3 Neurotransmitter Agents Phase 3
4
Histamine phosphate Phase 3 51-74-1 134614
5 Histamine H1 Antagonists, Non-Sedating Phase 3
6 Histamine H1 Antagonists Phase 3
7 Histamine Antagonists Phase 3
8 Cholinergic Antagonists Phase 3
9 Cholinergic Agents Phase 3
10
Glycerin Approved, Investigational Phase 1, Phase 2 56-81-5 753
11 Bifidobacterium Phase 2
12 Acidophilus Phase 2
13 Sulfalene Phase 2
14 Protective Agents Phase 1, Phase 2
15 Pharmaceutical Solutions Phase 2
16 Antibodies, Monoclonal Phase 2
17 Caseins Phase 2
18
Phenol Approved, Experimental Phase 1 108-95-2 996
19 Vaccines Phase 1
20 Antiviral Agents Phase 1
21 Anti-Infective Agents Phase 1
22 Hypoxanthine arabinoside Phase 1
23
BCG vaccine Approved, Investigational
24
Cetirizine Approved 83881-51-0 2678
25
Racephedrine Approved, Experimental 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
26
Ganciclovir Approved, Investigational 82410-32-0 3454
27
Fluticasone Approved, Experimental 90566-53-3 4659387 5311101
28
Selenium Approved, Investigational, Vet_approved 7783-07-5, 7782-49-2 533
29
Nitric Oxide Approved 10102-43-9 145068
30
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
31
Dexmedetomidine Approved, Experimental, Vet_approved 86347-14-0, 113775-47-6 68602 5311068
32
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
33
Ethanol Approved 64-17-5 702
34
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8 5280382 445354
35 Vitamins
36 Retinol palmitate
37 Central Nervous System Stimulants
38 Bronchodilator Agents
39 Adrenergic Agents
40 Vasoconstrictor Agents
41 Sympathomimetics
42 Nasal Decongestants
43 Antioxidants
44 Ganciclovir triphosphate
45 Endocrine Disruptors
46
Methacholine Chloride
47 Muscarinic Agonists
48 Omega 3 Fatty Acid
49 Olive
50 Xhance

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Multiple-Dose Safety and Tolerance Study of Desloratadine in Atopic Pediatric Subjects and Pediatric Subjects With Chronic Idiopathic Urticaria, Ages >=2 to <12 Years, Who Are Poor Metabolizers of Desloratadine Completed NCT00757562 Phase 3 desloratadine;Placebo
2 Effects of GOS/PDX Supplemented Formula in Preventing and Modifying the History of Allergy and Acute Infections in a Population of Infants at Risk of Atopy Completed NCT02116452 Phase 3
3 The Effects of PG102 on Allergy-related Risk Factors: A Randomized, Double Blind, Placebo Controlled Study Completed NCT01106703 Phase 2
4 Primary Prevention of Atopy and Asthma With House Dust Mite Sublingual Immunotherapy: 6-8 Years Follow up Completed NCT03763630 Phase 2 House dust-mite SLIT;Normal saline
5 Influence of Probiotics on Prevention of Atopy, Atopic Disease and Immunological Responses- A Randomized Double-Blind Placebo Controlled Trial Completed NCT00318695 Phase 2
6 A Follow-up Study to 5 Years of a Randomized, Double-blinded, Placebo-controlled Study on the Influence of Probiotics on Atopy, Immunological Responses and Gut Microflora Completed NCT00365469 Phase 2
7 Oral Desensitization to Egg With Subsequent Induction of Tolerance for Egg-Allergic Children (CoFAR 3) Completed NCT00461097 Phase 2 Egg oral immunotherapy;Control Group
8 A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut Allergy Completed NCT01084174 Phase 1, Phase 2 Peanut powder;Peanut extract;Placebo extract;Placebo powder
9 Sublingual Immunotherapy for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase I/II Pilot Study With a Whole Peanut Extract Completed NCT00580606 Phase 1, Phase 2 Glycerinated peanut allergenic extract;Placebo for peanut extract (glycerin)
10 Omalizumab Before Onset of Exacerbations Recruiting NCT05332067 Phase 2 Omalizumab;Placebo
11 A Phase 2 Study to Evaluate the Sensitivity, Specificity and Safety of DBV1605, a Ready-to-Use Atopy Patch Test for the Diagnosis of Non-Immunoglobulin E Mediated Cow's Milk Allergy in Children Recruiting NCT04492683 Phase 2
12 A Phase 1, Randomized, Double-Blind, Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK001 in Subjects With Atopic Disease Completed NCT02563938 Phase 1 AK001;Placebo
13 Food-Specific IgE, IgG, IgG4, Skin Prick Testing and Atopy Patch Testing in Children/Adolescents With Functional Dyspepsia: A Pilot Study Completed NCT00328679 Phase 1
14 Atopy Patch Test in Normal Population : Pilot Study Completed NCT01156038 Phase 1
15 Prevalence of Positive Reactions in Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms Completed NCT01164293 Phase 1
16 A Phase 1 Study of Heat/Phenol-Killed, E. Coli-Encapsulated, Recombinant Modified Peanut Proteins Ara h 1, Ara h 2, and Ara h 3 (EMP 123) in Healthy Volunteers Followed by Subjects Allergic to Peanuts (CoFAR 1) Completed NCT00850668 Phase 1
17 Cellular Inflammation Characterization of Nasal Challenges With Fine and Ultrafine Particles Completed NCT01257191 Phase 1 Carbon Black;Diesel Exhaust Particles;Fine Concentrated Ambient Particles;Ultrafine Concentrated Ambient Particles;Saline
18 The Effect of Omalizumab (Xolair) on Improving Neuropsychiatric Symptoms in a Subset of ASD Patients With Atopic Disease and Elevated Total IgE Levels Withdrawn NCT04535817 Phase 1 Omalizumab Injection [Xolair]
19 CT 327 in the "Atopy Patch Test" Model Withdrawn NCT01368315 Phase 1 CT327 application;Placebo;Active comparator;No intervention
20 Observational Study of Cord Blood Single Nucleotide Polymorphisms of Genes Related to Atopy and Allergic Diseases Unknown status NCT00444327
21 "Intestinal Microbiota Composition After Antibiotic Treatment in Early Life. The INCA Study" Unknown status NCT02536560
22 Predictors of Cord Blood Immunoglobin E (IgE) Levels Unknown status NCT00902096
23 The Effect of Vitamin A Supplementation at Birth on the Development of Atopy in Childhood: Long-term Follow-up of a Randomised Placebo-controlled Trial Unknown status NCT01779180
24 • Sleep Disturbance Among Patients With Psoriasis and Atopy and Comparison Between Them Unknown status NCT03864809
25 Efficacy of Local Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Times (0, 3 and 6 Months) Unknown status NCT02774629
26 ADELE: Autoimmune Defense and Living Environment Acronym Description: Adele Comes From the Capitalized Words in the Following Words: Autoimmune DEfense and Living Environment Unknown status NCT02733926
27 Effectiveness of Airway Control Using the IGEL Laryngeal Mask Airway Device in Patients With Previous Radiotherapy to the Neck Unknown status NCT03502590
28 A Randomized, Double-Blind, Placebo-Controlled Crossover Study to Assess the Efficacy's Reproducibility of a Combination of Pseudoephedrine and Cetirizine on Symptom Scores and Rhinomanometry in Patients With Allergic Rhinitis Following Pollen Exposure in the Fraunhofer Environmental Challenge Chamber (ECC) in- and Outside the Grass Pollen Season Completed NCT00474890 cetericine and pseudoephedrine
29 Dietary Intake, Allergy and Respiratory Diseases in European Adults From the GA2LEN Follow-up Survey Completed NCT03251157
30 Projeto JOIN - o ar Como Meio de prevenção e a diagnóstico da Asma e Alergia Completed NCT02802891
31 Redistribution of Pulmonary Perfusion During Bronchoconstriction in Asthma Completed NCT01547286 Nebulized methacholine inhalation
32 Protection Against Allergy: Study in Rural Environment - Part IV Completed NCT02929277
33 Characterization of the Expression and Activity of Inhibitory Receptors Such as CLM-1 in Eosinophils of Atopic Subjects Completed NCT01489293
34 Impact of Fish Oil Supplementation in 3rd Trimester of Pregnancy on Maternal and Offspring Health Completed NCT01353807
35 Airway Microbiome in Asthma: Relationships to Asthma Phenotype and Inhaled Corticosteroid Treatment Completed NCT01537133 fluticasone;Placebo
36 The Effects of Oily Fish in Pregnancy on Markers and Manifestations of Allergic Diseases in Infants at Risk of Atopy Completed NCT00801502
37 Atopy Patch Test in Children With Atopic Dermatitis Completed NCT02552979
38 A Follow-up Study to 7 Years of a Randomized, Double-blinded, Placebo-controlled Study on the Influence of Probiotics on Atopy With Focus on Respiratory Allergic Diseases Completed NCT00826189
39 Markers of Atopy in Children With Presumed Early Exposure to Allergens, Unhygienic Conditions, and Infections Completed NCT00503048
40 Comparison of Skin Prick Tests and Atopy Patch Test Results of Lyophilized Food Extracts at Different Storage Time (0, 3 and 6 Months) After Preparation Completed NCT03645629
41 Prevalence of Allergic Diseases and Atopy in Patients With Angiographically Confirmed Coronary Artery Disease Completed NCT01552161
42 Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflammation Completed NCT01295866
43 A Randomized Pragmatic Parallel Group Trial to Investigate the Effectiveness of a Standardized Skin Care Regimen to Prevent the Development of Atopic Dermatitis in Atopy Predisposed Infants Completed NCT02906475
44 Comparison of Difference Histamine Concentration (1, 5 and 10 mg/ml) for Positive Control of Skin Prick Test Completed NCT02561429
45 In-vivo Potency Evaluation of American Cockroach, Dog, Cat, Dust Mites and Mold Allergen Extracts Produced by Siriraj Hospital Comparing With Imported Extracts by Using Skin Prick Test. Completed NCT02561390
46 Diagnosis and Physiopathology of Insulin Allergy (IA) Completed NCT01407640
47 Clinical Determinants in Perioperative Allergic Immediate Hypersensitivity Completed NCT03918772
48 Role of Skin Tests for the Diagnosis of Immediate Hypersensitivity Reactions Due to Iodinated Contrast Media Completed NCT00819494
49 Interest of Challenge Tests for Diagnosis of Immediate Hypersensitivity Against Iodinated Contrast Agents Completed NCT03525496
50 Preducted Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction Completed NCT02268656 propofol concentration

Search NIH Clinical Center for Ige Responsiveness, Atopic

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Allergenic extract
ALLERGENIC EXTRACT, MIXED ANTIGENS
ALLERGENIC EXTRACT, YELLOW JACKET, WHOLE BODY
Alternaria alternata allergenic extract

Genetic Tests for Ige Responsiveness, Atopic

Genetic tests related to Ige Responsiveness, Atopic:

# Genetic test Affiliating Genes
1 Ige Responsiveness, Atopic 28 IL21R IL4R MS4A2 PLA2G7

Anatomical Context for Ige Responsiveness, Atopic

Organs/tissues related to Ige Responsiveness, Atopic:

MalaCards : Skin, Breast, Lung, T Cells, Bone Marrow, Liver, Brain

Publications for Ige Responsiveness, Atopic

Articles related to Ige Responsiveness, Atopic:

(show top 50) (show all 11385)
# Title Authors PMID Year
1
Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females. 57 5
12700598 2003
2
Effects of common atopy-associated amino acid substitutions in the IL-4 receptor alpha chain on IL-4 induced phenotypes. 53 62 5
15712015 2005
3
The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. 53 62 5
10233717 1999
4
The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. 53 62 5
9392697 1997
5
Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. 53 62 57
8094113 1993
6
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. 62 57
12754510 2003
7
Preliminary findings in corneal allograft rejection in patients with keratoconus. 62 57
12654360 2003
8
Identification of the autoantigen SART-1 as a candidate gene for the development of atopy. 62 57
12189166 2002
9
Positive association to IgE levels and a physical map of the 13q14 atopy locus. 62 57
12032735 2002
10
Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. 62 57
11378822 2001
11
IgE in asthma and atopy: cellular and molecular connections. 62 57
10510320 1999
12
Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population. 62 57
10400996 1999
13
Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. 62 5
9515586 1998
14
Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects. 62 57
7616543 1995
15
Linkage between severe atopy and chromosome 11q13 in Japanese families. 62 57
7820936 1994
16
Allele sharing on chromosome 11q13 in sibs with asthma and atopy. 62 57
8105198 1993
17
Chromosome 11q13 and atopy underlying atopic eczema. 62 57
8097806 1993
18
Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97. 62 57
1486536 1992
19
Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p. 62 57
1486537 1992
20
Genetic analysis of the linkage between chromosome 11q and atopy. 62 57
1362523 1992
21
Factors confounding genetic linkage between atopy and chromosome 11q. 62 57
1486532 1992
22
Lack of linkage between atopy and locus 11q13. 62 57
1486535 1992
23
Maternal inheritance of atopic IgE responsiveness on chromosome 11q. 62 57
1353553 1992
24
Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine. 62 57
1346795 1992
25
Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. 62 57
2566826 1989
26
Dominant inheritance of atopic immunoglobulin-E responsiveness. 62 57
2891984 1988
27
A study of the inheritance of atopic hypersensitivity in man. 62 57
13197361 1954
28
A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. 5
21339644 2011
29
NOD1 variation, immunoglobulin E and asthma. 57
15718249 2005
30
Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses. 57
16093728 2005
31
A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels. 57
15924217 2005
32
A germline mutation in KIT in familial diffuse cutaneous mastocytosis. 5
15173254 2004
33
Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. 57
14681301 2004
34
Immunology: hepatitis A virus link to atopic disease. 5
14534576 2003
35
Association of Eotaxin gene family with asthma and serum total IgE. 57
12761043 2003
36
Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families. 57
11093275 2000
37
No linkage or association of the IL-4Ralpha gene Q576R mutation with atopic asthma in Italian families. 5
10905893 2000
38
Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group. 57
10607813 1999
39
The interleukin-4 receptor variant Q576R in hyper-IgE syndrome. 5
9537881 1998
40
John Bostock, hay fever, and the mechanism of allergy. 57
1360571 1992
41
A major gene for allergy--fact or fancy? 57
1303274 1992
42
Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. 57
1583642 1992
43
Genetic linkage: interpreting lod scores. 57
1536004 1992
44
Atopic disease and immunoglobulin E in twins reared apart and together. 57
2018039 1991
45
Hypervariable 'minisatellite' regions in human DNA. 57
3856104 1985
46
The inheritance of immunoglobulin E: genetic linkage analysis. 57
6581721 1983
47
Inheritance of immunoglobulin E: genetic model fitting. 57
6829611 1983
48
Genetic transmission of serum IgE Levels. 57
7304670 1981
49
Immunoglobulin E revisited. 57
7395873 1980
50
A genetic study of immunoglobulin E. 57
623102 1978

Variations for Ige Responsiveness, Atopic

ClinVar genetic disease variations for Ige Responsiveness, Atopic:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 HAVCR1 HAVCR1, 6-AA INS INSERT Affects
4270 GRCh37:
GRCh38:
2 IL21R NM_181078.3(IL21R):c.-17+400T>C SNV Pathogenic
1247564 GRCh37: 16:27414339-27414339
GRCh38: 16:27403018-27403018
3 SPINK5 NM_006846.4(SPINK5):c.1431-12G>A SNV Likely Pathogenic
372516 rs368134354 GRCh37: 5:147484503-147484503
GRCh38: 5:148104940-148104940
4 IL4R NM_000418.4(IL4R):c.1727A>G (p.Gln576Arg) SNV Risk Factor
14665 rs1801275 GRCh37: 16:27374400-27374400
GRCh38: 16:27363079-27363079
5 SPINK5 NM_006846.4(SPINK5):c.891C>T (p.Cys297=) SNV Likely Pathogenic
374066 rs752941297 GRCh37: 5:147477438-147477438
GRCh38: 5:148097875-148097875
6 IL4R NM_000418.4(IL4R):c.1160C>T (p.Ser387Leu) SNV Uncertain Significance
626118 rs6413500 GRCh37: 16:27373833-27373833
GRCh38: 16:27362512-27362512
7 IL4R NM_000418.4(IL4R):c.1774G>T (p.Val592Leu) SNV Uncertain Significance
827982 rs138392496 GRCh37: 16:27374447-27374447
GRCh38: 16:27363126-27363126
8 IL21R-AS1, IL21R NM_181078.3(IL21R):c.1033G>A (p.Gly345Ser) SNV Uncertain Significance
225037 rs56148525 GRCh37: 16:27460020-27460020
GRCh38: 16:27448699-27448699
9 IL21R NM_181078.3(IL21R):c.-17+563G>A SNV Uncertain Significance
626116 rs117535117 GRCh37: 16:27414502-27414502
GRCh38: 16:27403181-27403181

Expression for Ige Responsiveness, Atopic

Search GEO for disease gene expression data for Ige Responsiveness, Atopic.

Pathways for Ige Responsiveness, Atopic

Pathways related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 STAT6 RNASE3 MS4A2 IL5 IL4R IL4
2
Show member pathways
13.45 STAT6 IL5 IL4R IL4 IL13 IL10
3
Show member pathways
13.28 STAT6 IL5 IL4R IL4 IL21R IL13
4
Show member pathways
13.2 IL10 IL13 IL4 IL4R IL5 PLA2G7
5
Show member pathways
12.6 STAT6 IL5 IL4R IL4 IL21R IL13
6
Show member pathways
12.5 STAT6 IL10 IFNG CD14
7 12.47 STAT6 IL4 IL10 IFNG
8
Show member pathways
12.21 STAT6 IL4R IL4 IGHE
9
Show member pathways
12.11 IL5 IL4 IL10 IFNG
10 12.03 CD14 IFNG IL10 IL4 IL5
11 12.03 STAT6 IL4R IL4 IL13 IL10 IFNG
12 11.99 STAT6 IL4R IL4 IL13 IL10
13 11.89 IL5 IL4 IL13 IL10 IFNG
14
Show member pathways
11.88 STAT6 IL4 IFNG
15
Show member pathways
11.87 IFNG IL21R IL4 IL4R
16 11.81 IFNG IL10 IL13 IL4 IL5
17 11.78 IL5 IL4 IL13 IFNG
18 11.72 IL5 IL4 IL10 IFNG
19 11.71 STAT6 IL4R IL4 IL21R IFNG
20 11.7 IL10 IFNG CD14
21 11.67 IL4 IL10 IFNG
22
Show member pathways
11.64 IL5 IL4 IFNG
23 11.61 IL5 IL4 IL13
24 11.61 IL10 IL4 IL4R IL5 STAT6
25 11.52 IL4R IL4 IL10 IFNG
26 11.49 IL4 IL4R STAT6
27 11.37 IL5 IL4R IL4 IFNG
28 11.34 IL5 IL4 IL13 IFNG
29 11.18 IL5 IL4 IL13 IL10 IFNG
30 11.16 STAT6 IL5 IL4R IL4 IL13 IL10
31 11.09 IFNG IL10 IL13 IL4 IL5
32
Show member pathways
11 STAT6 IL5 IL4R IL4 IL21R IL13
33 10.99 IL10 CD14
34 10.99 STAT6 IL4R IL4 IL21R
35 10.97 IL5 IL4 IL13 IL10 IFNG
36 10.94 IL4R IL4 IFNG
37 10.75 IL5 IL4R IL4 IL13

GO Terms for Ige Responsiveness, Atopic

Cellular components related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.98 CD14 CSN1S1 IFNG IGHE IL10 IL13
2 external side of plasma membrane GO:0009897 9.93 MS4A2 IL4R IL21R IL13 IGHE CD14
3 extracellular region GO:0005576 9.68 SPINK5 RNASE3 PLA2G7 IL5 IL4R IL4

Biological processes related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 10.14 STAT6 IL5 IL4R IL21R
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.06 IL4 IL13 IFNG
3 positive regulation of cold-induced thermogenesis GO:0120162 10.01 STAT6 IL4R IL4 IL13
4 positive regulation of cytokine production GO:0001819 10 IL10 IFNG CD14
5 positive regulation of B cell proliferation GO:0030890 10 IL5 IL4 IL13
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.95 IL4 IL13 IL10
7 positive regulation of signaling receptor activity GO:2000273 9.91 IL10 IFNG
8 positive regulation of cellular respiration GO:1901857 9.88 IL4 IFNG
9 T-helper 2 cell differentiation GO:0045064 9.87 IL4R IL4
10 type 2 immune response GO:0042092 9.86 IL4 IL10
11 neuroinflammatory response GO:0150076 9.85 IFNG IL4
12 microglial cell activation GO:0001774 9.85 IL4 IL13 IFNG
13 regulation of isotype switching GO:0045191 9.81 IL4 IL10
14 interleukin-4-mediated signaling pathway GO:0035771 9.8 STAT6 IL4R
15 positive regulation of macrophage activation GO:0043032 9.8 IL4R IL13 IL10
16 response to molecule of bacterial origin GO:0002237 9.77 IL10 CD14
17 positive regulation of isotype switching to IgE isotypes GO:0048295 9.76 IL4 STAT6
18 negative regulation of complement-dependent cytotoxicity GO:1903660 9.73 IL13 IL4
19 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IFNG IL10 IL4
20 positive regulation of mast cell degranulation GO:0043306 9.63 IL4R IL4 IL13
21 positive regulation of immunoglobulin production GO:0002639 9.56 IL5 IL4R IL13 IL10
22 immune response GO:0006955 9.47 MS4A2 IL5 IL4R IL4 IL13 IL10

Molecular functions related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 IL5 IL4 IL13 IL10 IFNG

Sources for Ige Responsiveness, Atopic

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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