IGER
MCID: IGR001
MIFTS: 59

Ige Responsiveness, Atopic (IGER)

Categories: Genetic diseases, Immune diseases

Aliases & Classifications for Ige Responsiveness, Atopic

MalaCards integrated aliases for Ige Responsiveness, Atopic:

Name: Ige Responsiveness, Atopic 58 30 6 74
Atopy 58 76 13 56 17 74
Atopy, Susceptibility to 58 6
Ige, Elevated Level of 58 6
Ige Response Underlying Allergic Asthma and Rhinitis 58
Immunoglobulin E, Basic Level of, in Serum 58
Hypersensitivity, Immediate 45
Immediate Hypersensitivity 74
Atopic Hypersensitivity 76
Ige, Level of; Igel 58
Ige, Level of 58
Iger 58
Igel 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
ige responsiveness, atopic:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Ige Responsiveness, Atopic

UniProtKB/Swiss-Prot : 76 Atopic hypersensitivity: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.

MalaCards based summary : Ige Responsiveness, Atopic, also known as atopy, is related to churg-strauss syndrome and dermatitis. An important gene associated with Ige Responsiveness, Atopic is IL21R (Interleukin 21 Receptor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include testes, skin and lung, and related phenotypes are asthma and eczema

Description from OMIM: 147050

Related Diseases for Ige Responsiveness, Atopic

Diseases related to Ige Responsiveness, Atopic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 351)
# Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 32.0 IL10 IL5 RNASE3
2 dermatitis 30.4 IFNG IGHE IL13 IL4 IL5 PHF11
3 sinusitis 30.4 IL4R IL5 RNASE3
4 rhinitis 30.4 IGHE IL13 IL4 IL4R IL5 RNASE3
5 pollen allergy 30.3 IL13 IL4R IL5 RNASE3
6 milk allergy 30.2 IL10 IL4 IL5 RNASE3
7 otitis media 30.1 IGHE IL10 IL4 RNASE3
8 contact dermatitis 30.1 IFNG IL10 IL4 IL5
9 pneumonia 30.0 IL10 IL13 IL5
10 vernal keratoconjunctivitis 29.9 IL13 IL4 IL5 RNASE3
11 drug allergy 29.9 IL4R IL5 MS4A2
12 aspergillosis 29.8 IFNG IL10 IL4 IL5
13 intrinsic asthma 29.8 IL4 IL5 RNASE3
14 allergic contact dermatitis 29.8 IFNG IL10 IL4 IL5
15 uveitis 29.7 IFNG IL10 IL4
16 chlamydia 29.7 IFNG IL10 IL4
17 pulmonary disease, chronic obstructive 29.7 ADRB2 IL13 RNASE3
18 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.7 IFNG IL10 IL4
19 hypereosinophilic syndrome 29.6 IGHE IL13 IL4 IL5 RNASE3
20 keratoconjunctivitis 29.6 IFNG IL13 IL4 IL5 RNASE3
21 cow milk allergy 29.6 IL10 IL5 RNASE3
22 mycoplasma pneumoniae pneumonia 29.5 IFNG IL10 IL13 IL4
23 latex allergy 29.5 IGHE IL13 IL4 IL5 RNASE3
24 filariasis 29.5 IFNG IL10 IL5
25 toxoplasmosis 29.5 IFNG IL10 IL4
26 pulmonary tuberculosis 29.4 IFNG IL10 IL4
27 lung disease 29.4 ADRB2 IL10 IL13 IL5 RNASE3
28 mycobacterium tuberculosis 1 29.4 IFNG IL10 IL4
29 allergic rhinitis 29.2 IFNG IGHE IL10 IL13 IL4 IL4R
30 parasitic helminthiasis infectious disease 29.2 IL10 IL13 IL4 IL5 RNASE3
31 food allergy 29.1 IFNG IL10 IL13 IL4 IL5 MS4A2
32 bronchiolitis 29.1 IFNG IGHE IL10 IL13 IL4 IL4R
33 tetanus 29.1 IFNG IL10 IL13 IL4 IL5
34 asthma 29.0 ADRB2 IFNG IGHE IL10 IL13 IL4
35 inflammatory bowel disease 28.8 IFNG IL10 IL13 IL21R IL4 STAT6
36 skin disease 28.8 IFNG IL10 IL13 IL4 IL5 RNASE3
37 dermatitis, atopic 28.7 IFNG IGHE IL10 IL13 IL4 IL4R
38 upper respiratory tract disease 28.6 IFNG IL10 IL13 IL4 IL5 MS4A2
39 malaria 28.5 IFNG IL10 IL13 IL4 IL5 IL9
40 respiratory allergy 28.2 IGHE IL10 IL13 IL4 IL4R IL5
41 allergic hypersensitivity disease 27.4 IFNG IGHE IL10 IL13 IL4 IL4R
42 allergic asthma 27.4 IFNG IGHE IL10 IL13 IL4 IL4R
43 asthma-related traits 4 11.3
44 allergic angiitis 11.3
45 eosinophilic granulomatosis with polyangiitis 11.3
46 immunodeficiency 23 11.3
47 neurodermatitis 11.3
48 peeling skin syndrome 1 11.2
49 asthma-related traits 1 11.1
50 asthma-related traits 2 11.1

Graphical network of the top 20 diseases related to Ige Responsiveness, Atopic:



Diseases related to Ige Responsiveness, Atopic

Symptoms & Phenotypes for Ige Responsiveness, Atopic

Human phenotypes related to Ige Responsiveness, Atopic:

33
# Description HPO Frequency HPO Source Accession
1 asthma 33 HP:0002099
2 eczema 33 HP:0000964
3 allergic rhinitis 33 HP:0003193
4 increased circulating total ige level 33 HP:0003212

Symptoms via clinical synopsis from OMIM:

58
Pulmonary:
asthma
hay fever

Immunology:
atopic hypersensitivity

Skin:
eczema

Lab:
ige level control

Clinical features from OMIM:

147050

MGI Mouse Phenotypes related to Ige Responsiveness, Atopic:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 ADRB2 CD14 IFNG IL10 IL13 IL21R
2 homeostasis/metabolism MP:0005376 10.03 ADRB2 CD14 IFNG IL10 IL13 IL21R
3 immune system MP:0005387 10.03 ADRB2 CD14 IFNG IL10 IL13 IL21R
4 endocrine/exocrine gland MP:0005379 9.97 ADRB2 IFNG IL10 IL13 IL21R IL4
5 digestive/alimentary MP:0005381 9.95 IFNG IL10 IL13 IL4 IL4R IL5
6 integument MP:0010771 9.5 IFNG IL10 IL13 IL4 IL4R SPINK5
7 respiratory system MP:0005388 9.28 CD14 IFNG IL10 IL13 IL4 IL4R

Drugs & Therapeutics for Ige Responsiveness, Atopic

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Vegetation in Kindergartens on the Immune Response of Children Active, not recruiting NCT02733926 Not Applicable

Search NIH Clinical Center for Ige Responsiveness, Atopic

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: hypersensitivity, immediate

Genetic Tests for Ige Responsiveness, Atopic

Genetic tests related to Ige Responsiveness, Atopic:

# Genetic test Affiliating Genes
1 Ige Responsiveness, Atopic 30 IL21R IL4R MS4A2 PLA2G7

Anatomical Context for Ige Responsiveness, Atopic

MalaCards organs/tissues related to Ige Responsiveness, Atopic:

42
Testes, Skin, Lung, T Cells, Breast, Prostate, Bone

Publications for Ige Responsiveness, Atopic

Articles related to Ige Responsiveness, Atopic:

(show top 50) (show all 2428)
# Title Authors Year
1
Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children. ( 30985951 )
2019
2
The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood. ( 30739516 )
2019
3
Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress. ( 30687959 )
2019
4
New IgE immediate hypersensitivity reactions on reintroduction of food restricted for treatment of eosinophilic esophagitis. ( 30684739 )
2019
5
Gut microbiota from infant with cow's milk allergy promotes clinical and immune features of atopy in a murine model. ( 30887528 )
2019
6
Follow up on atopy and the gastrointestinal tract - a review of a common association 2018. ( 30900475 )
2019
7
Validation of PROTIA™ Allergy-Q 64 Atopy® as a Specific IgE Measurement Assay for 10 Major Allergen Components. ( 30912330 )
2019
8
Patients with atopy exhibit reduced cortisol awakening response but not cortisol concentrations during the rest of the day. ( 31011985 )
2019
9
Germline CBM-opathies: From immunodeficiency to atopy. ( 31060714 )
2019
10
Family history of atopy in infants with cow's milk protein allergy: A French population-based study. ( 30885604 )
2019
11
Follow-up, 18 months off house dust mite immunotherapy, of a randomized controlled study on the primary prevention of atopy. ( 30737992 )
2019
12
Individual susceptibility to contact sensitization: the role of TNFα 308G>A polymorphism and atopy. ( 30698160 )
2019
13
Dominant-negative CARD11 mutations: beyond atopy. ( 30659853 )
2019
14
Atopy in chronic rhinosinusitis: impact on quality of life outcomes. ( 30604578 )
2019
15
Cord-serum per- and poly-fluoroalkyl substances and atopy and eczema at 12-months. ( 30428139 )
2019
16
High levels of butyrate and propionate in early life are associated with protection against atopy. ( 30390309 )
2019
17
Atopy patch test. ( 30058560 )
2019
18
Allergy and atopy from infancy to adulthood: Messages from the German birth cohort MAS. ( 29803707 )
2019
19
Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasma pneumoniae pneumonia. ( 30924557 )
2019
20
A Nationwide, Population-based Cohort Study on Potential Autoimmune Association of Ménière Disease to Atopy and Vitiligo. ( 30867466 )
2019
21
Atopy and Sensitization to Allergens Known to Cause Systemic Contact Dermatitis. ( 30640765 )
2019
22
Food-Related Contact Dermatitis, Contact Urticaria, and Atopy Patch Test with Food. ( 29881951 )
2019
23
Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood. ( 30145365 )
2019
24
Asthma and atopy prevalence are not reduced among former tuberculosis patients compared with controls in Lima, Peru. ( 30760258 )
2019
25
Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents. ( 30923181 )
2019
26
Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32-35 weeks. ( 31001655 )
2019
27
Prevalence of atopy and allergic rhinitis in patients with adult non-cystic fibrosis bronchiectasis ( 30997791 )
2019
28
An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions. ( 30964555 )
2019
29
Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions. ( 31029409 )
2019
30
Preventive Effect of Changing Contrast Media in Patients With A Prior Mild Immediate Hypersensitivity Reaction to Gadolinium-Based Contrast Agent. ( 31033674 )
2019
31
GATA2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in humans. ( 31102699 )
2019
32
Contrast media and cutaneous reactions. Part 1. Immediate hypersensitivity reactions to contrast media and gadolinium deposition. ( 31112335 )
2019
33
Incidence and risk factors of low-osmolar iodinated contrast media related immediate hypersensitivity reactions: A longitudinal study based on a real-time monitoring system. ( 30676320 )
2019
34
Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis. ( 30758852 )
2019
35
Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary. ( 30820197 )
2019
36
Short and extended provocation tests have similar negative predictive value in non-immediate hypersensitivity to beta-lactams in children. ( 30910271 )
2019
37
Immediate hypersensitivity to p-phenylenediamine. ( 30426523 )
2019
38
Skin tests in patients with delayed and immediate hypersensitivity to heparins: A case series. ( 30450556 )
2019
39
Repeat Contrast Medium Administration for Patients with Mild Immediate Hypersensitivity Reaction to Iodinated Contrast Media. ( 30511910 )
2019
40
Immediate Hypersensitivity to Cindamycin: Rare, But Not Impossible. ( 30598183 )
2019
41
Tolerability of iobitridol in patients with non-immediate hypersensitivity reactions to iodinated contrast media. ( 30225896 )
2019
42
Role of Skin Tests in the Diagnosis of Immediate Hypersensitivity Reactions to Taxanes: Results of a Multicenter Study. ( 30292919 )
2019
43
African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children. ( 30548437 )
2018
44
Atopy in Patients With Ocular Cicatricial Pemphigoid. ( 29341971 )
2018
45
Atopic dermatitis in US adults: Epidemiology, association with marital status, and atopy. ( 30036584 )
2018
46
Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis. ( 29542298 )
2018
47
Efficacy of Atopy Patch Testing in Directed Dietary Therapy of Eosinophilic Esophagitis: A Pilot Study. ( 29349695 )
2018
48
Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy. ( 29031891 )
2018
49
Does atopy affect the course of viral pneumonia? ( 28634031 )
2018
50
Specific IgE Assay for Respiratory Allergens in Patients with Atopy in Ahvaz, Iran. ( 30593743 )
2018

Variations for Ige Responsiveness, Atopic

ClinVar genetic disease variations for Ige Responsiveness, Atopic:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HAVCR1 HAVCR1, 6-AA INS insertion Affects
2 IL21R IL21R, -83T-C single nucleotide variant Pathogenic
3 IL4R NM_000418.3(IL4R): c.1727A> G (p.Gln576Arg) single nucleotide variant risk factor rs1801275 GRCh37 Chromosome 16, 27374400: 27374400
4 IL4R NM_000418.3(IL4R): c.1727A> G (p.Gln576Arg) single nucleotide variant risk factor rs1801275 GRCh38 Chromosome 16, 27363079: 27363079
5 IL4R NM_000418.4(IL4R): c.1160C> T (p.Ser387Leu) single nucleotide variant Uncertain significance GRCh37 Chromosome 16, 27373833: 27373833
6 IL4R NM_000418.4(IL4R): c.1160C> T (p.Ser387Leu) single nucleotide variant Uncertain significance GRCh38 Chromosome 16, 27362512: 27362512
7 IL21R NM_181079.4(IL21R): c.11G> A (p.Arg4His) single nucleotide variant Uncertain significance GRCh37 Chromosome 16, 27414502: 27414502
8 IL21R NM_181079.4(IL21R): c.11G> A (p.Arg4His) single nucleotide variant Uncertain significance GRCh38 Chromosome 16, 27403181: 27403181

Expression for Ige Responsiveness, Atopic

Search GEO for disease gene expression data for Ige Responsiveness, Atopic.

Pathways for Ige Responsiveness, Atopic

Pathways related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD14 IFNG IGHE IL10 IL13 IL4
2
Show member pathways
13.63 CD14 IFNG IL10 IL13 IL21R IL4
3
Show member pathways
13.49 IFNG IL10 IL13 IL4 IL4R IL5
4
Show member pathways
13.36 IL10 IL13 IL4 IL4R IL5 IL9
5
Show member pathways
13.31 IFNG IGHE IL10 IL13 IL4 IL4R
6
Show member pathways
13.25 IL10 IL13 IL4 IL4R IL5 IL9
7
Show member pathways
12.85 IFNG IL10 IL13 IL4 IL4R IL5
8 12.82 IFNG IL13 IL4 IL4R IL5 STAT6
9
Show member pathways
12.74 IL21R IL4 IL4R IL9 STAT6
10
Show member pathways
12.61 IFNG IGHE IL10 IL4 IL4R MS4A2
11
Show member pathways
12.57 IFNG IL10 IL13 IL21R IL4 IL4R
12
Show member pathways
12.56 IGHE IL13 IL4 IL5 MS4A2
13
Show member pathways
12.55 IFNG IL10 IL4 IL5 IL9
14
Show member pathways
12.52 CD14 IFNG IL10 STAT6
15 12.5 IFNG IL10 IL4 STAT6
16
Show member pathways
12.35 IGHE IL4 IL4R STAT6
17
Show member pathways
12.29 IFNG IL13 IL4 IL5
18
Show member pathways
12.24 IFNG IL10 IL13 IL4 IL5 IL9
19
Show member pathways
12.17 IFNG IL10 IL13 IL21R IL4 IL4R
20
Show member pathways
12.05 IFNG IL10 IL13 IL4 IL4R IL5
21
Show member pathways
12.02 CD14 IFNG IL13 IL4
22 12.01 IGHE IL10 IL13 IL4 IL4R STAT6
23 11.99 CD14 IFNG IL10 IL4 IL5
24
Show member pathways
11.98 IFNG IL10 IL21R
25
Show member pathways
11.92 IFNG IL4 STAT6
26 11.89 CD14 IL4 IL4R IL5
27 11.88 IFNG IL10 IL21R IL4R STAT6
28 11.84 CD14 IFNG IL10
29 11.81 IFNG IL13 IL4 IL5
30 11.74 IFNG IL10 IL13 IL4
31
Show member pathways
11.73 IFNG IL4 IL5
32 11.71 CD14 IFNG IL10
33 11.7 IFNG IL10 IL13 IL4 IL5 IL9
34 11.63 IL13 IL4 IL5
35 11.55 IL10 IL21R IL4R
36 11.53 IGHE IL10 IL4 IL4R IL5 STAT6
37 11.5 IL10 IL13 IL4
38 11.33 IFNG IL4 IL4R IL5
39 11.31 IFNG IL13 IL4 IL5 IL9
40 11.23 IFNG IL10 IL13 IL4 IL5
41 11.2 IL10 IL13 IL4 IL5 IL9
42 10.98 IL10 IL13 IL4 IL5 IL9
43 10.89 IFNG IL10 IL13 IL4 IL4R IL5
44 10.85 IFNG IL10 IL13 IL4 IL5 IL9

GO Terms for Ige Responsiveness, Atopic

Cellular components related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 CD14 IFNG IL10 IL13 IL4 IL4R
2 external side of plasma membrane GO:0009897 9.46 CD14 IGHE IL13 MS4A2
3 extracellular region GO:0005576 9.4 CD14 IFNG IGHE IL10 IL13 IL4

Biological processes related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.88 ADRB2 CD14 IFNG MS4A2
2 regulation of signaling receptor activity GO:0010469 9.85 IFNG IL10 IL13 IL4 IL5 IL9
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 IFNG IL13 IL4
4 inflammatory response GO:0006954 9.73 CD14 IL10 IL13 IL5 IL9 MS4A2
5 positive regulation of B cell proliferation GO:0030890 9.65 IL13 IL4 IL5
6 defense response to protozoan GO:0042832 9.59 IL10 IL4R
7 response to molecule of bacterial origin GO:0002237 9.58 CD14 IL10
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 IL10 IL13 IL4
9 positive regulation of mast cell degranulation GO:0043306 9.57 IL13 IL4R
10 positive regulation of immunoglobulin production GO:0002639 9.55 IL13 IL4R
11 positive regulation of cold-induced thermogenesis GO:0120162 9.55 ADRB2 IL13 IL4 IL4R STAT6
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL10 IL4
13 interleukin-4-mediated signaling pathway GO:0035771 9.52 IL4R STAT6
14 regulation of isotype switching GO:0045191 9.51 IL10 IL4
15 positive regulation of macrophage activation GO:0043032 9.5 IL10 IL13 IL4R
16 cytokine-mediated signaling pathway GO:0019221 9.5 IGHE IL10 IL13 IL4 IL4R IL5
17 type 2 immune response GO:0042092 9.49 IL10 IL4
18 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL13 IL4
19 positive regulation of isotype switching to IgE isotypes GO:0048295 9.43 IL4 STAT6
20 immune response GO:0006955 9.28 IFNG IGHE IL10 IL13 IL4 IL4R

Molecular functions related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL4 IL5 IL9
2 cytokine receptor binding GO:0005126 9.13 IL13 IL4 IL9
3 cytokine activity GO:0005125 9.1 IFNG IL10 IL13 IL4 IL5 IL9

Sources for Ige Responsiveness, Atopic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....