Ige Responsiveness, Atopic disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

IGER MCID: IGR001 MIFTS: 57	Ige Responsiveness, Atopic (IGER) Categories: Genetic diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Ige Responsiveness, Atopic

MalaCards integrated aliases for Ige Responsiveness, Atopic:

Name: Ige Responsiveness, Atopic ⁵⁷ ²⁸ ⁵ ⁷¹

Atopy ⁵⁷ ⁷³ ¹² ⁵³ ¹⁶ ⁷¹

Atopy, Susceptibility to ⁵⁷ ⁵

Ige, Elevated Level of ⁵⁷ ⁵

Ige Response Underlying Allergic Asthma and Rhinitis ⁵⁷

Immunoglobulin E, Basic Level of, in Serum ⁵⁷

Immediate Hypersensitivity ⁷¹

Atopic Hypersensitivity ⁷³

Ige, Level of ⁵⁷

Iger ⁵⁷

Igel ⁵⁷

Characteristics:

Inheritance:

Autosomal dominant ⁵⁷

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 147050

MeSH ⁴³ D006969

MedGen ⁴⁰ C0020523 C0236175 C1840253 more

SNOMED-CT via HPO ⁶⁹ 195967001 281104002 43116000 more

EFO ¹⁶ EFO_0002686

UMLS ⁷¹ C0020523 C0392707 C1840253

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Summaries for Ige Responsiveness, Atopic

UniProtKB/Swiss-Prot: ⁷³ A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.

MalaCards based summary: Ige Responsiveness, Atopic, also known as atopy, is related to chronic rhinitis and churg-strauss syndrome. An important gene associated with Ige Responsiveness, Atopic is IL21R (Interleukin 21 Receptor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Histamine and Desloratadine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lung, and related phenotypes are asthma and eczema

More information from OMIM: 147050

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Related Diseases for Ige Responsiveness, Atopic

Diseases related to Ige Responsiveness, Atopic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 683)

#	Related Disease	Score	Top Affiliating Genes
1	chronic rhinitis	31.2	RNASE3 IL5 IL4 IL13
2	churg-strauss syndrome	31.0	RNASE3 IL5 IL10
3	respiratory syncytial virus infectious disease	30.8	IL5 IL13
4	irritant dermatitis	30.3	IL4 IL13
5	alopecia areata	30.3	IL4 IL13 IFNG
6	drug allergy	30.3	IL5 IL4 IL13 IGHE
7	latex allergy	30.2	IL13 IGHE
8	occupational asthma	30.1	RNASE3 IL5 IL4 IL13
9	neurodermatitis	30.0	IL4 IL13
10	scabies	30.0	IL5 IL4 IL13
11	ascaris lumbricoides infection	30.0	IL5 IL4 IL13 IL10
12	eosinophilic gastroenteritis	30.0	RNASE3 IL5 IL4 IL13 IGHE
13	viral infectious disease	30.0	IL4 IL13 IL10 IFNG
14	exanthem	30.0	IL4 IL10 IFNG
15	hepatitis a	29.9	IL4 IL10 IFNG
16	exercise-induced bronchoconstriction	29.9	RNASE3 IL5 IL4 IL13 IGHE
17	chronic spontaneous urticaria	29.9	IL5 IL4 IL13
18	chronic urticaria	29.9	RNASE3 IL5 IGHE
19	common cold	29.8	RNASE3 IL5 IL4 IL13 IL10
20	pollen allergy	29.8	IL5 IL4 IL13 IL10
21	rhinitis	29.8	RNASE3 IL5 IL4R IL4 IL13 IL10
22	adenoid hypertrophy	29.8	IL5 IL4 IL10
23	enterocolitis	29.8	IL10 CD14
24	primary cutaneous t-cell non-hodgkin lymphoma	29.8	IL5 IL4 IFNG
25	eosinophilic gastritis	29.7	IL5 IL13
26	aspergillosis	29.7	IL5 IL4 IL10 IFNG
27	anisakiasis	29.7	RNASE3 IGHE
28	vernal keratoconjunctivitis	29.7	RNASE3 IL4 IL13 IGES
29	mycosis fungoides	29.6	IL5 IL4 IFNG
30	bronchitis	29.6	RNASE3 IL5 IL4 IL13 IL10 IGHE
31	diphtheria	29.6	IL5 IL4 IL13 IFNG
32	cough variant asthma	29.6	RNASE3 IL5 IL4 IL13
33	vasomotor rhinitis	29.6	RNASE3 IL5 IL4 IL13
34	toxoplasmosis	29.6	IL5 IL4 IL10 IFNG
35	autoimmune disease	29.6	IL5 IL4 IL13 IL10 IFNG
36	esophagitis, eosinophilic, 1	29.6	STAT6 SPINK5 RNASE3 IL5 IL4 IL13
37	keratoconjunctivitis	29.5	RNASE3 IL5 IL4 IL13 IFNG
38	lipoid nephrosis	29.5	IL4R IL13 IL10
39	intrinsic asthma	29.5	RNASE3 IL5 IL4 IL13 IL10 IGHE
40	type 1 diabetes mellitus	29.5	PLA2G7 IL4 IL10 IFNG
41	cellulitis	29.5	RNASE3 IL5 IGES
42	chickenpox	29.5	IL4 IL10 IFNG
43	allergic bronchopulmonary aspergillosis	29.5	IL5 IL4 IL13 IGHE IGES IFNG
44	angioedema	29.4	IL5 IL10 IGHE
45	thyroiditis	29.4	IL4 IL10 IFNG
46	dermatitis	29.4	SPINK5 RNASE3 IL5 IL4R IL4 IL13
47	uveitis	29.4	IL4 IL10 IFNG
48	igg4-related disease	29.4	IL5 IL4 IL13 IL10
49	filarial elephantiasis	29.4	IL5 IL4 IL13 IL10
50	chlamydia	29.4	IL5 IL4 IL10 IFNG

Graphical network of the top 20 diseases related to Ige Responsiveness, Atopic:

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Symptoms & Phenotypes for Ige Responsiveness, Atopic

Human phenotypes related to Ige Responsiveness, Atopic:

³⁰

#	Description	HPO Source Accession
1	asthma ³⁰	HP:0002099
2	eczema ³⁰	HP:0000964
3	allergic rhinitis ³⁰	HP:0003193
4	increased circulating ige level ³⁰	HP:0003212

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 08-Dec-2022)

Pulmonary:
asthma
hay fever

Immunology:
atopic hypersensitivity

Skin:
eczema

Lab:
ige level control

Clinical features from OMIM®:

147050 (Updated 08-Dec-2022)

MGI Mouse Phenotypes related to Ige Responsiveness, Atopic:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.1	CD14 IFNG IGHE IL10 IL13 IL21R
2	respiratory system	MP:0005388	9.81	CD14 IFNG IL10 IL13 IL4 IL4R
3	hematopoietic system	MP:0005397	9.77	CD14 IFNG IGHE IL10 IL13 IL21R
4	integument	MP:0010771	9.23	CSN1S1 IFNG IL10 IL13 IL4 IL4R

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Drugs & Therapeutics for Ige Responsiveness, Atopic

Drugs for Ige Responsiveness, Atopic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Histamine

Approved, Investigational

Phase 3

51-45-6

774

Desloratadine

Approved, Investigational

Phase 3

100643-71-8

124087

Neurotransmitter Agents

Phase 3

Histamine phosphate

Phase 3

51-74-1

134614

Histamine H1 Antagonists, Non-Sedating

Phase 3

Histamine H1 Antagonists

Phase 3

Histamine Antagonists

Phase 3

Cholinergic Antagonists

Phase 3

Cholinergic Agents

Phase 3

Glycerin

Approved, Investigational

Phase 1, Phase 2

56-81-5

753

Bifidobacterium

Phase 2

Acidophilus

Phase 2

Sulfalene

Phase 2

Protective Agents

Phase 1, Phase 2

Pharmaceutical Solutions

Phase 2

Antibodies, Monoclonal

Phase 2

Caseins

Phase 2

Phenol

Approved, Experimental

Phase 1

108-95-2

996

Vaccines

Phase 1

Antiviral Agents

Phase 1

Anti-Infective Agents

Phase 1

Hypoxanthine arabinoside

Phase 1

BCG vaccine

Approved, Investigational

Cetirizine

Approved

83881-51-0

2678

Racephedrine

Approved, Experimental

299-42-3, 90-82-4, 90-81-3

5032 9294 7028

Ganciclovir

Approved, Investigational

82410-32-0

3454

Fluticasone

Approved, Experimental

90566-53-3

4659387 5311101

Selenium

Approved, Investigational, Vet_approved

7783-07-5, 7782-49-2

533

Nitric Oxide

Approved

10102-43-9

145068

Racepinephrine

Approved, Vet_approved

51-43-4, 329-65-7

838 5816

Dexmedetomidine

Approved, Experimental, Vet_approved

86347-14-0, 113775-47-6

68602 5311068

Propofol

Approved, Investigational, Vet_approved

2078-54-8

4943

Ethanol

Approved

64-17-5

702

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 68-26-8

5280382 445354

Vitamins

Retinol palmitate

Central Nervous System Stimulants

Bronchodilator Agents

Adrenergic Agents

Vasoconstrictor Agents

Sympathomimetics

Nasal Decongestants

Antioxidants

Ganciclovir triphosphate

Endocrine Disruptors

Methacholine Chloride

Muscarinic Agonists

Omega 3 Fatty Acid

Olive

Xhance

Interventional clinical trials:

(show top 50) (show all 68)

#	Name	Status	NCT ID	Phase	Drugs
1	Multiple-Dose Safety and Tolerance Study of Desloratadine in Atopic Pediatric Subjects and Pediatric Subjects With Chronic Idiopathic Urticaria, Ages >=2 to <12 Years, Who Are Poor Metabolizers of Desloratadine	Completed	NCT00757562	Phase 3	desloratadine;Placebo
2	Effects of GOS/PDX Supplemented Formula in Preventing and Modifying the History of Allergy and Acute Infections in a Population of Infants at Risk of Atopy	Completed	NCT02116452	Phase 3
3	The Effects of PG102 on Allergy-related Risk Factors: A Randomized, Double Blind, Placebo Controlled Study	Completed	NCT01106703	Phase 2
4	Primary Prevention of Atopy and Asthma With House Dust Mite Sublingual Immunotherapy: 6-8 Years Follow up	Completed	NCT03763630	Phase 2	House dust-mite SLIT;Normal saline
5	Influence of Probiotics on Prevention of Atopy, Atopic Disease and Immunological Responses- A Randomized Double-Blind Placebo Controlled Trial	Completed	NCT00318695	Phase 2
6	A Follow-up Study to 5 Years of a Randomized, Double-blinded, Placebo-controlled Study on the Influence of Probiotics on Atopy, Immunological Responses and Gut Microflora	Completed	NCT00365469	Phase 2
7	Oral Desensitization to Egg With Subsequent Induction of Tolerance for Egg-Allergic Children (CoFAR 3)	Completed	NCT00461097	Phase 2	Egg oral immunotherapy;Control Group
8	A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut Allergy	Completed	NCT01084174	Phase 1, Phase 2	Peanut powder;Peanut extract;Placebo extract;Placebo powder
9	Sublingual Immunotherapy for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase I/II Pilot Study With a Whole Peanut Extract	Completed	NCT00580606	Phase 1, Phase 2	Glycerinated peanut allergenic extract;Placebo for peanut extract (glycerin)
10	Omalizumab Before Onset of Exacerbations	Recruiting	NCT05332067	Phase 2	Omalizumab;Placebo
11	A Phase 2 Study to Evaluate the Sensitivity, Specificity and Safety of DBV1605, a Ready-to-Use Atopy Patch Test for the Diagnosis of Non-Immunoglobulin E Mediated Cow's Milk Allergy in Children	Recruiting	NCT04492683	Phase 2
12	A Phase 1, Randomized, Double-Blind, Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK001 in Subjects With Atopic Disease	Completed	NCT02563938	Phase 1	AK001;Placebo
13	Food-Specific IgE, IgG, IgG4, Skin Prick Testing and Atopy Patch Testing in Children/Adolescents With Functional Dyspepsia: A Pilot Study	Completed	NCT00328679	Phase 1
14	Atopy Patch Test in Normal Population : Pilot Study	Completed	NCT01156038	Phase 1
15	Prevalence of Positive Reactions in Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms	Completed	NCT01164293	Phase 1
16	A Phase 1 Study of Heat/Phenol-Killed, E. Coli-Encapsulated, Recombinant Modified Peanut Proteins Ara h 1, Ara h 2, and Ara h 3 (EMP 123) in Healthy Volunteers Followed by Subjects Allergic to Peanuts (CoFAR 1)	Completed	NCT00850668	Phase 1
17	Cellular Inflammation Characterization of Nasal Challenges With Fine and Ultrafine Particles	Completed	NCT01257191	Phase 1	Carbon Black;Diesel Exhaust Particles;Fine Concentrated Ambient Particles;Ultrafine Concentrated Ambient Particles;Saline
18	The Effect of Omalizumab (Xolair) on Improving Neuropsychiatric Symptoms in a Subset of ASD Patients With Atopic Disease and Elevated Total IgE Levels	Withdrawn	NCT04535817	Phase 1	Omalizumab Injection [Xolair]
19	CT 327 in the "Atopy Patch Test" Model	Withdrawn	NCT01368315	Phase 1	CT327 application;Placebo;Active comparator;No intervention
20	Observational Study of Cord Blood Single Nucleotide Polymorphisms of Genes Related to Atopy and Allergic Diseases	Unknown status	NCT00444327
21	"Intestinal Microbiota Composition After Antibiotic Treatment in Early Life. The INCA Study"	Unknown status	NCT02536560
22	Predictors of Cord Blood Immunoglobin E (IgE) Levels	Unknown status	NCT00902096
23	The Effect of Vitamin A Supplementation at Birth on the Development of Atopy in Childhood: Long-term Follow-up of a Randomised Placebo-controlled Trial	Unknown status	NCT01779180
24	• Sleep Disturbance Among Patients With Psoriasis and Atopy and Comparison Between Them	Unknown status	NCT03864809
25	Efficacy of Local Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Times (0, 3 and 6 Months)	Unknown status	NCT02774629
26	ADELE: Autoimmune Defense and Living Environment Acronym Description: Adele Comes From the Capitalized Words in the Following Words: Autoimmune DEfense and Living Environment	Unknown status	NCT02733926
27	Effectiveness of Airway Control Using the IGEL Laryngeal Mask Airway Device in Patients With Previous Radiotherapy to the Neck	Unknown status	NCT03502590
28	A Randomized, Double-Blind, Placebo-Controlled Crossover Study to Assess the Efficacy's Reproducibility of a Combination of Pseudoephedrine and Cetirizine on Symptom Scores and Rhinomanometry in Patients With Allergic Rhinitis Following Pollen Exposure in the Fraunhofer Environmental Challenge Chamber (ECC) in- and Outside the Grass Pollen Season	Completed	NCT00474890		cetericine and pseudoephedrine
29	Dietary Intake, Allergy and Respiratory Diseases in European Adults From the GA2LEN Follow-up Survey	Completed	NCT03251157
30	Projeto JOIN - o ar Como Meio de prevenção e a diagnóstico da Asma e Alergia	Completed	NCT02802891
31	Redistribution of Pulmonary Perfusion During Bronchoconstriction in Asthma	Completed	NCT01547286		Nebulized methacholine inhalation
32	Protection Against Allergy: Study in Rural Environment - Part IV	Completed	NCT02929277
33	Characterization of the Expression and Activity of Inhibitory Receptors Such as CLM-1 in Eosinophils of Atopic Subjects	Completed	NCT01489293
34	Impact of Fish Oil Supplementation in 3rd Trimester of Pregnancy on Maternal and Offspring Health	Completed	NCT01353807
35	Airway Microbiome in Asthma: Relationships to Asthma Phenotype and Inhaled Corticosteroid Treatment	Completed	NCT01537133		fluticasone;Placebo
36	The Effects of Oily Fish in Pregnancy on Markers and Manifestations of Allergic Diseases in Infants at Risk of Atopy	Completed	NCT00801502
37	Atopy Patch Test in Children With Atopic Dermatitis	Completed	NCT02552979
38	A Follow-up Study to 7 Years of a Randomized, Double-blinded, Placebo-controlled Study on the Influence of Probiotics on Atopy With Focus on Respiratory Allergic Diseases	Completed	NCT00826189
39	Markers of Atopy in Children With Presumed Early Exposure to Allergens, Unhygienic Conditions, and Infections	Completed	NCT00503048
40	Comparison of Skin Prick Tests and Atopy Patch Test Results of Lyophilized Food Extracts at Different Storage Time (0, 3 and 6 Months) After Preparation	Completed	NCT03645629
41	Prevalence of Allergic Diseases and Atopy in Patients With Angiographically Confirmed Coronary Artery Disease	Completed	NCT01552161
42	Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflammation	Completed	NCT01295866
43	A Randomized Pragmatic Parallel Group Trial to Investigate the Effectiveness of a Standardized Skin Care Regimen to Prevent the Development of Atopic Dermatitis in Atopy Predisposed Infants	Completed	NCT02906475
44	Comparison of Difference Histamine Concentration (1, 5 and 10 mg/ml) for Positive Control of Skin Prick Test	Completed	NCT02561429
45	In-vivo Potency Evaluation of American Cockroach, Dog, Cat, Dust Mites and Mold Allergen Extracts Produced by Siriraj Hospital Comparing With Imported Extracts by Using Skin Prick Test.	Completed	NCT02561390
46	Diagnosis and Physiopathology of Insulin Allergy (IA)	Completed	NCT01407640
47	Clinical Determinants in Perioperative Allergic Immediate Hypersensitivity	Completed	NCT03918772
48	Role of Skin Tests for the Diagnosis of Immediate Hypersensitivity Reactions Due to Iodinated Contrast Media	Completed	NCT00819494
49	Interest of Challenge Tests for Diagnosis of Immediate Hypersensitivity Against Iodinated Contrast Agents	Completed	NCT03525496
50	Preducted Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction	Completed	NCT02268656		propofol concentration

Search NIH Clinical Center for Ige Responsiveness, Atopic

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Allergenic extract

ALLERGENIC EXTRACT, MIXED ANTIGENS

ALLERGENIC EXTRACT, YELLOW JACKET, WHOLE BODY

Alternaria alternata allergenic extract

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Genetic Tests for Ige Responsiveness, Atopic

Genetic tests related to Ige Responsiveness, Atopic:

#	Genetic test	Affiliating Genes
1	Ige Responsiveness, Atopic ²⁸	IL21R IL4R MS4A2 PLA2G7

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Anatomical Context for Ige Responsiveness, Atopic

Organs/tissues related to Ige Responsiveness, Atopic:

MalaCards : Skin, Breast, Lung, T Cells, Bone Marrow, Liver, Brain

Sources

Publications for Ige Responsiveness, Atopic

Articles related to Ige Responsiveness, Atopic:

(show top 50) (show all 11385)

#	Title	Authors	PMID	Year
1	Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females. ⁵⁷ ⁵	Hecker M...Hackstein H	12700598	2003
2	Effects of common atopy-associated amino acid substitutions in the IL-4 receptor alpha chain on IL-4 induced phenotypes. ⁵³ ⁶² ⁵	Franjkovic I...Bein G	15712015	2005
3	The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. ⁵³ ⁶² ⁵	Kruse S...Deichmann KA	10233717	1999
4	The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. ⁵³ ⁶² ⁵	Hershey GK...Chatila TA	9392697	1997
5	Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. ⁵³ ⁶² ⁵⁷	Sandford AJ...Cookson WO	8094113	1993
6	Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. ⁶² ⁵⁷	Zhang Y...Cookson WO	12754510	2003
7	Preliminary findings in corneal allograft rejection in patients with keratoconus. ⁶² ⁵⁷	Hargrave S...Niederkorn J	12654360	2003
8	Identification of the autoantigen SART-1 as a candidate gene for the development of atopy. ⁶² ⁵⁷	Wheatley AP...Hall IP	12189166	2002
9	Positive association to IgE levels and a physical map of the 13q14 atopy locus. ⁶² ⁵⁷	Anderson GG...Cookson WO	12032735	2002
10	Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. ⁶² ⁵⁷	Moffatt MF...Cookson WO	11378822	2001
11	IgE in asthma and atopy: cellular and molecular connections. ⁶² ⁵⁷	Oettgen HC...Geha RS	10510320	1999
12	Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population. ⁶² ⁵⁷	Kimura K...Hamaguchi H	10400996	1999
13	Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. ⁶² ⁵	Deichmann KA...Kuehr J	9515586	1998
14	Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects. ⁶² ⁵⁷	Hizawa N...Kawakami Y	7616543	1995
15	Linkage between severe atopy and chromosome 11q13 in Japanese families. ⁶² ⁵⁷	Shirakawa T...Morimoto K	7820936	1994
16	Allele sharing on chromosome 11q13 in sibs with asthma and atopy. ⁶² ⁵⁷	Collee JM...Gerritsen J	8105198	1993
17	Chromosome 11q13 and atopy underlying atopic eczema. ⁶² ⁵⁷	Coleman R...Harper JI	8097806	1993
18	Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97. ⁶² ⁵⁷	Rich SS...Blumenthal MN	1486536	1992
19	Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p. ⁶² ⁵⁷	Amelung PJ...Meyers DA	1486537	1992
20	Genetic analysis of the linkage between chromosome 11q and atopy. ⁶² ⁵⁷	Lympany P...Lee TH	1362523	1992
21	Factors confounding genetic linkage between atopy and chromosome 11q. ⁶² ⁵⁷	Moffatt MF...Hopkin JM	1486532	1992
22	Lack of linkage between atopy and locus 11q13. ⁶² ⁵⁷	Hizawa N...Kawakami Y	1486535	1992
23	Maternal inheritance of atopic IgE responsiveness on chromosome 11q. ⁶² ⁵⁷	Cookson WO...Nakumura Y	1353553	1992
24	Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine. ⁶² ⁵⁷	Lympany P...Lee TH	1346795	1992
25	Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. ⁶² ⁵⁷	Cookson WO...Hopkin JM	2566826	1989
26	Dominant inheritance of atopic immunoglobulin-E responsiveness. ⁶² ⁵⁷	Cookson WO...Hopkin JM	2891984	1988
27	A study of the inheritance of atopic hypersensitivity in man. ⁶² ⁵⁷	TIPS RL	13197361	1954
28	A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. ⁵	Kim HY...Rosenzweig SD	21339644	2011
29	NOD1 variation, immunoglobulin E and asthma. ⁵⁷	Hysi P...Cookson WO	15718249	2005
30	Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses. ⁵⁷	Mathias RA...Barnes KC	16093728	2005
31	A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels. ⁵⁷	Sharma S...Ghosh B	15924217	2005
32	A germline mutation in KIT in familial diffuse cutaneous mastocytosis. ⁵	Tang X...Burden AD	15173254	2004
33	Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. ⁵⁷	Shin HD...Park CS	14681301	2004
34	Immunology: hepatitis A virus link to atopic disease. ⁵	McIntire JJ...Umetsu DT	14534576	2003
35	Association of Eotaxin gene family with asthma and serum total IgE. ⁵⁷	Shin HD...Park CS	12761043	2003
36	Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families. ⁵⁷	Palmer LJ...Cookson WO	11093275	2000
37	No linkage or association of the IL-4Ralpha gene Q576R mutation with atopic asthma in Italian families. ⁵	Patuzzo C...Pignatti PF	10905893	2000
38	Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group. ⁵⁷	Milgrom H...Metzger WJ	10607813	1999
39	The interleukin-4 receptor variant Q576R in hyper-IgE syndrome. ⁵	Grimbacher B...Puck JM	9537881	1998
40	John Bostock, hay fever, and the mechanism of allergy. ⁵⁷	Finn R	1360571	1992
41	A major gene for allergy--fact or fancy? ⁵⁷	Marsh DG...Meyers DA	1303274	1992
42	Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. ⁵⁷	Young RP...Hopkin JM	1583642	1992
43	Genetic linkage: interpreting lod scores. ⁵⁷	Risch N	1536004	1992
44	Atopic disease and immunoglobulin E in twins reared apart and together. ⁵⁷	Hanson B...Blumenthal MN	2018039	1991
45	Hypervariable 'minisatellite' regions in human DNA. ⁵⁷	Jeffreys AJ...Thein SL	3856104	1985
46	The inheritance of immunoglobulin E: genetic linkage analysis. ⁵⁷	Meyers DA...Amos DB	6581721	1983
47	Inheritance of immunoglobulin E: genetic model fitting. ⁵⁷	Hasstedt SJ...Marsh DG	6829611	1983
48	Genetic transmission of serum IgE Levels. ⁵⁷	Blumenthal MN...Yunis E	7304670	1981
49	Immunoglobulin E revisited. ⁵⁷	Rao DC...Gerrard JW	7395873	1980
50	A genetic study of immunoglobulin E. ⁵⁷	Gerrard JW...Morton NE	623102	1978

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Genes for Ige Responsiveness, Atopic

Genes related to Ige Responsiveness, Atopic (4 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IL21R	Interleukin 21 Receptor	Protein Coding	1050	Molecular basis known ⁵⁷ Pathogenic ⁵ Genetic Tests ²⁸ Typically genetic variations that lead to apparently abnormal laboratory test values ⁵⁷	12700598
2	IL4R	Interleukin 4 Receptor	Protein Coding	684.97	Molecular basis known ⁵⁷ Genetic Tests ²⁸ Susceptibility factor ⁵⁷ Risk factor ⁵ Novoseek inferred ⁵³	9392697 9515586 10233717 (more) 9537881 10905893 15173254 15712015 9864378 15007345 10600010 10390422 10677312 11908817 15007352 11488673 15737301 10699178 10809862 15497451 16280132 10051727 12897746 11709756 10976388 17901851 15969687 14984008 12911786 11285129 11667956 19421745 16867043 10434569 11258628 17083349 14551599 15564773 18433792 10550746
3	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	669.14	Molecular basis known ⁵⁷ Genetic Tests ²⁸ Susceptibility factor ⁵⁷ Novoseek inferred ⁵³ GeneCards inferred via : Gene name (show sections)	15788141 15087090 10550754 (more) 11071084 17321582 9856836 8579333 8994858 16216168 11101848 11742288 19211233 12944417 8543789 9521597 19796196 1741930 15248847 8466634 16839402 15940119 16354184 10837062 19218813 18186810 10810222 12487211 9424407
4	PLA2G7	Phospholipase A2 Group VII	Protein Coding	650	Molecular basis known ⁵⁷ Genetic Tests ²⁸ Susceptibility factor ⁵⁷
5	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	33.58	Likely pathogenic ⁵ Novoseek inferred ⁵³	12752122 19534795
6	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	22.09	Novoseek inferred ⁵³	10795645 9561922 11716123 (more) 8517144 12500981 2083405 8486912 7654701 12354937 18605088 18958652 20196607 9230725 1281180 20176269 19815119 15842955 15379589 12456938 12214775 11240941 9839864 11529900 11472381 9338614 8762228 8535611 1517920 2058819 15317322 12843997 9792655 9768578 9420138 9142134 17956015 12372998 11150010 10932085 10757856 15456620 14677309 11980283 10903725 10902132 10473174 9723564 9389303 12495970 18845114 11745361 9883889 7560660 9346867 1468553 17383539 16178872 15199058 10435468 10224096 9608537 7503399 8465384 1543206 18282544 12752597 10998022 10586891 9819207 9623503 9087159 9017491 8953258 8070071 2407920 19266080 18928689 12514394 11802449 9330071 9677600 10457106 17355242 15737301 18221478 19833116 8959356 9700036 15064938 15356546 1953921 18507785 1743217 8947338 10753021 10966514 8087191 16911358 19409604 11894732 8957114 8094113 19201013 17208588 14610477 19230960 10027433 1777834 7749975 17321582 7798546 2182698 10664935 10764318 8087657 18954502 14609036 10090539 8704860 18266833 18079498 12897746 11282774 9872829 9863999 15972499 2142510 18039679 17125763 14727456 11831453 10887336 8828526 8657503 19015841 16506215 11876750 8877153 20224668 18450128 16937753 16095143 15584318 11240959 10641562 8132221 1373339 2299096 16433860 16640000 7935095 1444507 18507202 17983380 16618361 16446545 16788244 16306212 12002726 11208657 10209690 9487341 7798543 2376023 1683236 1831617 1443445 8133835 9136153 9657660 10608194 10450859 15564773 15208584 15080837 12383022 12358341 12209102 12199428 11069631
7	IL4	Interleukin 4	Protein Coding	16.4	Novoseek inferred ⁵³	1906280 9950598 12880687 (more) 18538381 7558124 9677601 7575356 9411594 10753021 15087090 12911786 11990231 9150836 15007352 11467989 11110575 10852746 10334974 10224407 8132221 15969687 14763936 8543789 8616554 9351597 9641571 16155260 8863163 11601337 12473063 11097315 10434569 10191921 10051727 9864378 7924574 19471606 16379312 14568741 9876771 9392706 9130485 8898936 1306210 1444507 19254294 19239423 15372320 15001290 11496248 9737657 7812887 8397256 8466634 15639296 15919378 14707464 10087404 7594582 1687726 1997656 19910025 12752590 12459539 10887336 9551956 8980464 7812882 18384428 18284263 16914241 16215326 15064938 11295659 10899762 10390422 10069428 9988446 12900808 12653165 11704288 10922233 10810222 7648454 12897746 12220464 11069564 11005866 10600010 19085588 11274077 10652462 10699178
8	IL13	Interleukin 13	Protein Coding	16.37	Novoseek inferred ⁵³	12372121 8980464 16024972 (more) 10699178 11588017 16433854 15064938 18417506 19254294 15007352 10808176 10652462 11274077 11419948 15208584 19433108 15356556 11678850 15557695 15100678 14641544 12680858 9988446 9876771 11704288 11149983 12897746 17560640 17091279 16421047 15080812 12949127 12580907 10887320 18037162 15969687 15639296 15919378 11825773 10219773 19011907 16750991 16272823 18502398 19471606 20126925 9864378 10434569 11467989
9	IL5	Interleukin 5	Protein Coding	16.05	Novoseek inferred ⁵³	1906280 11019593 12372121 (more) 16178872 9411594 17362254 16433854 11274077 15805995 19471606 9072996 10922233 1306210 9876771 9111503 1687726 1997656 12580907 15639296 9988446 8898936 1444507 19397755 9389297 10191921 11467989 15649267
10	IGES	Immunoglobulin E Concentration, Serum	Genetic Locus	15.57	Novoseek inferred ⁵³	15317322 15988535 11581439 (more) 15610365 17392323 16759385 17355242 12528600 15170037 18039679 19330659 1563501 9863999 18165216 17121586
11	RNASE3	Ribonuclease A Family Member 3	Protein Coding	11.86	Novoseek inferred ⁵³	11019593 15536407 15584318 (more) 15244224 9727762 10209690 18312335 19760211 10669113 17111810 9014602 10414419 18284263 9556008 14630983 8466634 11551254 10202344 7841728 10202995 8554357 10536888 11174187
12	CSN1S1	Casein Alpha S1	Protein Coding	9.51	Novoseek inferred ⁵³	8092439 2007924 15829656 (more) 12512191 17300640 12642834 9062633
13	PHF11	PHD Finger Protein 11	Protein Coding	8.25	GeneCards inferred via : Gene name (show sections)
14	IFNG	Interferon Gamma	Protein Coding	7.84	Novoseek inferred ⁵³	15100678 9265988 11990231 (more) 17121582 9150836 11467989 7499682 10329817 14722209 12473063 16379312 10843428 18284263 15064938 9988446 9876771 19733295 12928311 18079498 15649267 11097315 8132221 15080812 11941317 10491309 9088657 8397256 19191889 15639296 11893858 10852746 19874320 18384428 9389297 17179689 14568741 11601337 19085588 19433108 8865270
15	CD14	CD14 Molecule	Protein Coding	7.64	Novoseek inferred ⁵³	17949800 18312481 17877764 (more) 16306212 18417506 16505608 14501433 15602630 17075287 20126925 15867866 16142747 14617510 12580907 19096003 16950285 20109750 11282774 11994712 15649267 20109306
16	IL10	Interleukin 10	Protein Coding	7.5	Novoseek inferred ⁵³	15765744 18422446 20232770 (more) 11095260 19852851 9351597 15208584 11467989 19397755 19733295 9988446 11878129 16387603 17349011 15639296 15104195 18384428 15248850 15191022 9876771 16210901 15372320 16867043 17873741 15866239 15497451
17	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	7.21	Novoseek inferred ⁵³	11678849 15105161 11069563 (more) 11912010

Sources

Variations for Ige Responsiveness, Atopic

ClinVar genetic disease variations for Ige Responsiveness, Atopic:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	HAVCR1	HAVCR1, 6-AA INS	INSERT	Affects	4270		GRCh37: GRCh38:
2	IL21R	NM_181078.3(IL21R):c.-17+400T>C	SNV	Pathogenic	1247564		GRCh37: 16:27414339-27414339 GRCh38: 16:27403018-27403018
3	SPINK5	NM_006846.4(SPINK5):c.1431-12G>A	SNV	Likely Pathogenic	372516	rs368134354	GRCh37: 5:147484503-147484503 GRCh38: 5:148104940-148104940
4	IL4R	NM_000418.4(IL4R):c.1727A>G (p.Gln576Arg)	SNV	Risk Factor	14665	rs1801275	GRCh37: 16:27374400-27374400 GRCh38: 16:27363079-27363079
5	SPINK5	NM_006846.4(SPINK5):c.891C>T (p.Cys297=)	SNV	Likely Pathogenic	374066	rs752941297	GRCh37: 5:147477438-147477438 GRCh38: 5:148097875-148097875
6	IL4R	NM_000418.4(IL4R):c.1160C>T (p.Ser387Leu)	SNV	Uncertain Significance	626118	rs6413500	GRCh37: 16:27373833-27373833 GRCh38: 16:27362512-27362512
7	IL4R	NM_000418.4(IL4R):c.1774G>T (p.Val592Leu)	SNV	Uncertain Significance	827982	rs138392496	GRCh37: 16:27374447-27374447 GRCh38: 16:27363126-27363126
8	IL21R-AS1, IL21R	NM_181078.3(IL21R):c.1033G>A (p.Gly345Ser)	SNV	Uncertain Significance	225037	rs56148525	GRCh37: 16:27460020-27460020 GRCh38: 16:27448699-27448699
9	IL21R	NM_181078.3(IL21R):c.-17+563G>A	SNV	Uncertain Significance	626116	rs117535117	GRCh37: 16:27414502-27414502 GRCh38: 16:27403181-27403181

Sources

Expression for Ige Responsiveness, Atopic

Search GEO for disease gene expression data for Ige Responsiveness, Atopic.

Sources

Pathways for Ige Responsiveness, Atopic

Pathways related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

(show all 37)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.9	STAT6 RNASE3 MS4A2 IL5 IL4R IL4
2	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.45	STAT6 IL5 IL4R IL4 IL13 IL10
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.28	STAT6 IL5 IL4R IL4 IL21R IL13
4	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.2	IL10 IL13 IL4 IL4R IL5 PLA2G7
5	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.6	STAT6 IL5 IL4R IL4 IL21R IL13
6	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.5	STAT6 IL10 IFNG CD14
7	NF-kappaB Signaling ³	12.47	STAT6 IL4 IL10 IFNG
8	Development IGF-1 receptor signaling ²² Show member pathways Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.21	STAT6 IL4R IL4 IGHE
9	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.11	IL5 IL4 IL10 IFNG
10	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.03	CD14 IFNG IL10 IL4 IL5
11	Neuroinflammation and glutamatergic signaling ⁷⁴	12.03	STAT6 IL4R IL4 IL13 IL10 IFNG
12	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.99	STAT6 IL4R IL4 IL13 IL10
13	Allograft rejection ⁷⁴	11.89	IL5 IL4 IL13 IL10 IFNG
14	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.88	STAT6 IL4 IFNG
15	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.87	IFNG IL21R IL4 IL4R
16	Innate Lymphoid Cells Differentiation ⁶⁵	11.81	IFNG IL10 IL13 IL4 IL5
17	Glucocorticoid receptor regulatory network ⁶¹	11.78	IL5 IL4 IL13 IFNG
18	AP-1 transcription factor network ⁶¹	11.72	IL5 IL4 IL10 IFNG
19	Th17 cell differentiation pathway ⁷⁴	11.71	STAT6 IL4R IL4 IL21R IFNG
20	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.7	IL10 IFNG CD14
21	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.67	IL4 IL10 IFNG
22	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.64	IL5 IL4 IFNG
23	Lung fibrosis ⁷⁴	11.61	IL5 IL4 IL13
24	IL4-mediated signaling events ⁶¹	11.61	IL10 IL4 IL4R IL5 STAT6
25	THC Differentiation Pathway ⁶⁴	11.52	IL4R IL4 IL10 IFNG
26	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	11.49	IL4 IL4R STAT6
27	Inflammatory response pathway ⁷⁴	11.37	IL5 IL4R IL4 IFNG
28	Development and heterogeneity of the ILC family ⁷⁴	11.34	IL5 IL4 IL13 IFNG
29	Cytokines and inflammatory response ⁷⁴	11.18	IL5 IL4 IL13 IL10 IFNG
30	Th2 Differentiation ⁶⁵	11.16	STAT6 IL5 IL4R IL4 IL13 IL10
31	Immune infiltration in pancreatic cancer ⁷⁴	11.09	IFNG IL10 IL13 IL4 IL5
32	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11	STAT6 IL5 IL4R IL4 IL21R IL13
33	LDL- influence on CD14 and TLR4 ⁷⁴	10.99	IL10 CD14
34	IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.99	STAT6 IL4R IL4 IL21R
35	OX40 Pathway ⁶⁴	10.97	IL5 IL4 IL13 IL10 IFNG
36	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.94	IL4R IL4 IFNG
37	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.75	IL5 IL4R IL4 IL13

Sources

GO Terms for Ige Responsiveness, Atopic

Cellular components related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.98	CD14 CSN1S1 IFNG IGHE IL10 IL13
2	external side of plasma membrane	GO:0009897	9.93	MS4A2 IL4R IL21R IL13 IGHE CD14
3	extracellular region	GO:0005576	9.68	SPINK5 RNASE3 PLA2G7 IL5 IL4R IL4

Biological processes related to Ige Responsiveness, Atopic according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	10.14	STAT6 IL5 IL4R IL21R
2	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	10.06	IL4 IL13 IFNG
3	positive regulation of cold-induced thermogenesis	GO:0120162	10.01	STAT6 IL4R IL4 IL13
4	positive regulation of cytokine production	GO:0001819	10	IL10 IFNG CD14
5	positive regulation of B cell proliferation	GO:0030890	10	IL5 IL4 IL13
6	negative regulation of endothelial cell apoptotic process	GO:2000352	9.95	IL4 IL13 IL10
7	positive regulation of signaling receptor activity	GO:2000273	9.91	IL10 IFNG
8	positive regulation of cellular respiration	GO:1901857	9.88	IL4 IFNG
9	T-helper 2 cell differentiation	GO:0045064	9.87	IL4R IL4
10	type 2 immune response	GO:0042092	9.86	IL4 IL10
11	neuroinflammatory response	GO:0150076	9.85	IFNG IL4
12	microglial cell activation	GO:0001774	9.85	IL4 IL13 IFNG
13	regulation of isotype switching	GO:0045191	9.81	IL4 IL10
14	interleukin-4-mediated signaling pathway	GO:0035771	9.8	STAT6 IL4R
15	positive regulation of macrophage activation	GO:0043032	9.8	IL4R IL13 IL10
16	response to molecule of bacterial origin	GO:0002237	9.77	IL10 CD14
17	positive regulation of isotype switching to IgE isotypes	GO:0048295	9.76	IL4 STAT6
18	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.73	IL13 IL4
19	positive regulation of MHC class II biosynthetic process	GO:0045348	9.73	IFNG IL10 IL4
20	positive regulation of mast cell degranulation	GO:0043306	9.63	IL4R IL4 IL13
21	positive regulation of immunoglobulin production	GO:0002639	9.56	IL5 IL4R IL13 IL10
22	immune response	GO:0006955	9.47	MS4A2 IL5 IL4R IL4 IL13 IL10