MCID: IGG007
MIFTS: 48

Igg4-Related Disease

Categories: Bone diseases, Endocrine diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Igg4-Related Disease

MalaCards integrated aliases for Igg4-Related Disease:

Name: Igg4-Related Disease 12 73 20 58 15
Multifocal Fibrosclerosis 20 70 32
Igg4-Related Systemic Disease 20 58
Igg4-Positive Multiorgan Lymphoproliferative Syndrome 20
Immunoglobulin G4-Related Sclerosing Diseases 58
Immunoglobulin G4-Related Sclerosing Disease 20
Systemic Igg4-Related Plasmacytic Syndrome 20
Systemic Igg4-Related Sclerosing Syndrome 20
Igg4-Related Systemic Sclerosing Disease 20
Multifocal Idiopathic Fibrosclerosis 20
Retroperitoneal Fibrosis, Familial 20
Igg4-Related Sclerosing Diseases 58
Igg4-Related Autoimmune Disease 20
Igg4-Related Sclerosing Disease 20
Mediastinal Fibrosis, Familial 20
Igg4-Associated Disease 20
Igg4-Related Diseases 58
Hyper-Igg4 Disease 20
Igg4-Syndrome 20
Igg4-Rd 58

Characteristics:

Orphanet epidemiological data:

58
igg4-related diseases
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


External Ids:

Disease Ontology 12 DOID:0080356
ICD10 32 M35.5
UMLS via Orphanet 71 C3203653
UMLS 70 C0494949

Summaries for Igg4-Related Disease

GARD : 20 IgG4-related disease is an immune-mediated condition that can affect multiple organ systems. Common features include IgG4-related autoimmune pancreatitis, swelling of or within an organ system (an inflammatory pseudotumor), salivary gland disease (which can lead to enlargement of the salivary glands), swollen lymph nodes ( lymphadenopathy ), skin manifestations, and symptoms consistent with allergies or asthma. The cause of IgG4-related disease is unknown. Some researchers believe that it may be an autoimmune or allergic disorder. IgG4-related disease is usually treated with systemic steroids like prednisone. Immunosuppressive medications ( azathioprine or mycophenolate mofetil ) and biologics ( rituximab or bortezomib ) may be used in those who don't respond to steroids or for longer-term management. In severe cases, organ replacement therapy may be needed.

MalaCards based summary : Igg4-Related Disease, also known as multifocal fibrosclerosis, is related to mikulicz disease and autoimmune pancreatitis. An important gene associated with Igg4-Related Disease is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Betamethasone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, salivary gland and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An autoimmune disease that is characterized by tumefactive lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, obliterative phlebitis, autoimmune pancreatitis, and sometimes elevated serum IgG4 levels affecting various organs.

Wikipedia : 73 IgG4-Related Disease(IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic... more...

Related Diseases for Igg4-Related Disease

Diseases related to Igg4-Related Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 628)
# Related Disease Score Top Affiliating Genes
1 mikulicz disease 31.8 TNFSF13B IL4 CRP CCR6
2 autoimmune pancreatitis 31.7 TNFSF13B IL33 IFNA1
3 hypereosinophilic syndrome 31.0 IL4 IFNA1 CCL17
4 sialadenitis 30.9 TNFSF13B ICOSLG CCR6
5 thyroiditis 30.8 IL4 IFNA1 CRP
6 dacryoadenitis 30.7 IL4 ICOSLG CCR6
7 autoimmune hepatitis 30.6 PDCD1 IL4 IFNA1
8 purpura 30.6 TNFSF13B IL4 CRP
9 polyclonal hypergammaglobulinemia 30.4 TNFSF13B CRP
10 scleritis 30.4 IL4 CRP CCR6
11 interstitial lung disease 30.3 IL4 IL33 CRP CCL17
12 granulomatosis with polyangiitis 30.2 ICOSLG CRP CCR6
13 keratoconjunctivitis sicca 30.2 TNFSF13B IL4 CCR6
14 hashimoto thyroiditis 30.2 LGALS3 IL4 CCR6
15 lymphoma, mucosa-associated lymphoid type 30.2 TNFSF13B ICOSLG CCR6 AICDA
16 burkitt lymphoma 30.1 TNFSF13B IL4 IFNA1 AICDA
17 cholangitis, primary sclerosing 30.1 ICOSLG CRP CCR6
18 interstitial nephritis 30.0 PDCD1 ICOSLG CRP CCR6
19 rhinitis 30.0 NR3C1 IL4 IL33 ICOSLG
20 kimura disease 29.9 PLA2R1 IL4 IFNA1
21 salivary gland disease 29.9 TNFSF13B ICOSLG CCR6
22 pemphigus vulgaris, familial 29.9 TNFSF13B CCR6 CCL17
23 viral hepatitis 29.8 IL4 IFNA1 CRP
24 dermatitis 29.8 IL4 IL33 CCR6 CCL17
25 vitiligo-associated multiple autoimmune disease susceptibility 1 29.7 PDCD1 ICOSLG CCR6
26 sarcoidosis 1 29.7 ICOSLG CRP CCR6
27 pustulosis of palm and sole 29.6 CRP CCR6
28 anemia, autoimmune hemolytic 29.6 TNFSF13B ICOSLG CCR6
29 posterior uveitis 29.6 IL4 ICOSLG CCR6
30 autoimmune disease 29.6 TNFSF13B PDCD1 IL4 IFNA1 ICOSLG CRP
31 chronic conjunctivitis 29.5 IL4 IL33 ICOSLG CCR6
32 asthma 29.5 NR3C1 IL4 IL33 ICOSLG CCR6 CCL17
33 esophagitis, eosinophilic, 1 29.5 IL4 IL33 ICOSLG CCR6
34 common cold 29.5 IL4 IL33 ICOSLG CCR6
35 bile duct disease 29.5 ICOSLG CRP CCR6
36 panuveitis 29.4 ICOSLG CRP CCR6
37 dermatitis, atopic 29.2 LGALS3 IL4 IL33 ICOSLG CCR6 CCL17
38 systemic scleroderma 29.2 IL4 ICOSLG CRP CCR6
39 thyroid gland disease 29.2 LGALS3 ICOSLG CRP CCR6
40 crohn's disease 29.2 IL4 ICOSLG CRP CCR6
41 exanthem 29.2 PDCD1 IFNA1 ICOSLG CRP CCR6
42 dilated cardiomyopathy 29.1 PDCD1 LGALS3 IL4 IFNA1 GDF15 CRP
43 lymphadenitis 29.1 PDCD1 ICOSLG CRP CCR6
44 allergic disease 29.1 TLR7 NR3C1 IL4 IL33 ICOSLG CCR6
45 rheumatoid arthritis 29.1 TNFSF13B PDCD1 NR3C1 IL4 CRP CCR6
46 skin disease 29.1 IL4 IFNA1 ICOSLG CRP CCR6 CCL17
47 pulmonary fibrosis, idiopathic 29.1 LGALS3 IL4 IL33 CRP CCR6 CCL17
48 thrombocytopenia 29.1 TNFSF13B TLR7 PDCD1 IL4 IFNA1 CRP
49 peripheral nervous system disease 29.1 IL4 ICOSLG CRP CCR6
50 inflammatory bowel disease 29.0 NR3C1 IL4 IL33 ICOSLG CRP CCR6

Graphical network of the top 20 diseases related to Igg4-Related Disease:



Diseases related to Igg4-Related Disease

Symptoms & Phenotypes for Igg4-Related Disease

MGI Mouse Phenotypes related to Igg4-Related Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 AICDA CCL17 CCR6 GDF15 IL33 IL4
2 homeostasis/metabolism MP:0005376 9.73 AICDA CCR6 CRP GDF15 IL33 IL4
3 immune system MP:0005387 9.44 AICDA CCL17 CCR6 CRP IL33 IL4

Drugs & Therapeutics for Igg4-Related Disease

Drugs for Igg4-Related Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8
belimumab Approved Phase 4 356547-88-1 5957 10451420
9
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
10 Betamethasone benzoate Phase 4
11 Betamethasone sodium phosphate Phase 4
12 Betamethasone-17,21-dipropionate Phase 4
13 Betamethasone dipropionate, betamethasone sodium phosphate drug combination Phase 4
14 Betamethasone Valerate Phase 4 2152-44-5
15 Liver Extracts Phase 4
16 Hormones Phase 4
17 Methylprednisolone Acetate Phase 4
18 Hormone Antagonists Phase 4
19 Immunologic Factors Phase 4
20 Anti-Inflammatory Agents Phase 4
21 Antineoplastic Agents, Hormonal Phase 4
22 Antibodies, Monoclonal Phase 3
23
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
24
Abatacept Approved Phase 2 332348-12-6 10237
25
Zanubrutinib Approved, Investigational Phase 2 1691249-45-2
26 Antibiotics, Antitubercular Phase 2
27 Anti-Bacterial Agents Phase 2
28 Antitubercular Agents Phase 2
29 Anti-Infective Agents Phase 2
30 Antineoplastic Agents, Immunological Phase 1, Phase 2
31 Antirheumatic Agents Phase 1, Phase 2
32 Protein Kinase Inhibitors Phase 2
33
Lenalidomide Approved Phase 1 191732-72-6 216326
34 Angiogenesis Inhibitors Phase 1
35
Leflunomide Approved, Investigational 75706-12-6 3899
36
Mycophenolic acid Approved 24280-93-1 446541
37
Methotrexate Approved 1959-05-2, 59-05-2 126941
38
Azathioprine Approved 446-86-6 2265
39 Fluorodeoxyglucose F18 Early Phase 1
40 Fluorides Early Phase 1
41 Radiopharmaceuticals Early Phase 1
42 Antimetabolites Early Phase 1
43 Antiviral Agents Early Phase 1
44 Deoxyglucose Early Phase 1
45 Immunosuppressive Agents
46 glucocorticoids
47 Immunoglobulins
48 Immunoglobulin G
49 Immunoglobulins, Intravenous
50 Antibodies

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 To Evaluate the Clinical Efficacy of Iguratimod in the Treatment of IgG4 Related Disease (IgG4-RD) With Mild Symptom Unknown status NCT03368274 Phase 4 T 614
2 A Study of Safety and Efficacy of Leflunomide for Maintenance of Remission in IgG4 Related Disease Completed NCT02703194 Phase 4 Prednisone;Leflunomide
3 Belimumab Treatment for IgG4-related Disease, a Prospective, Open-label Clinical Trial Recruiting NCT04660565 Phase 4 Prednisone and Belimumab;Prednisone
4 A Randomized Trial of Glucocorticoids in Patients With IgG4-Related Disease Unknown status NCT01758393 Phase 2, Phase 3 Prednisone
5 A Phase 3, Randomized, Double-blind, Multicenter, Placebo Controlled Study of Inebilizumab Efficacy and Safety in IgG4-Related Disease Recruiting NCT04540497 Phase 3 Inebilizumab
6 A Randomized Trial of Treatment in Patients With IgG4-Related Disease Unknown status NCT02458196 Phase 2 Prednisone;Prednisone and Mycophenolate mofetil
7 An Open-label, Single-arm, Pilot Study to Evaluate the Effect of XmAb®5871 on Disease Activity in Patients With IgG4-Related Disease Completed NCT02725476 Phase 2
8 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
9 A Prospective, Open-label, Single Center Abatacept in IgG4-Related Disease 10-patient Proof-of-concept Study Completed NCT03669861 Phase 2 Abatacept
10 An Open Label, Two-Arm Study to Evaluate the Effect of Rilzabrutinib (PRN1008) on Safety and Disease Activity in Patients With IgG4-Related Disease Recruiting NCT04520451 Phase 2 rilzabrutinib;Glucocorticoids
11 A Phase II, Single-Site, Open-Label Study of Zanubrutinib in Patients With IgG4-Related Disease Not yet recruiting NCT04602598 Phase 2 Zanubrutinib 80 MG
12 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
13 Plasmablast Detection From IgG4-Related Disease Patients Unknown status NCT03466970
14 A Laboratory Scan of Patients With Aortic Aneurysms to IgG4 Levels in the Blood Unknown status NCT03267875
15 Evaluation of 18F-FDG PET/CT in Diagnosis and Response Assessment of Patients With IgG4-Related Disease Unknown status NCT01665196 Early Phase 1 18F-FDG
16 Characterization of Tissular T Follicular Helper Cells in IgG4-RD Unknown status NCT02872441
17 Leflunomide Treatment for IgG4-RD Unknown status NCT03715699 Prednisone;Prednisone and Leflunomide
18 A Survey of Patients With Elevated Serum IGG4 With Unknown IGG4-related Disease to Whom Biopsy and Performance of Subsequent Specific Staining for Clinical, Laboratory and Pathologic Correlation. Completed NCT02229448
19 Infraorbital Nerve Involvement on Magnetic Resonance Imaging in European Patients With IgG4-related Ophthalmic Disease Completed NCT03690908
20 Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease Completed NCT02899039
21 Detection of Circulating Plasmablast in Diagnosis and Relapse Prediction of IgG4 Related Diseases Recruiting NCT04539197
22 National Registry of IgG4-RD in China Recruiting NCT03023371
23 Characterizing IgG4-related Disease With 68Ga-FAPI PET/CT Recruiting NCT04125511 Early Phase 1 68Ga-FAPI
24 Impact of COVID-19 on the Clinical Outcomes and Management of IgG4 Related Disease Patients With Pancreatobiliary Involvement: a Multicenter Retrospective Study Recruiting NCT04817553
25 Cohort Study of Patients With IgG4-Related Disease Recruiting NCT01670695
26 Evaluation and Prediction of Relapse Risk After Glucocorticoid and Immunosuppressant Withdrawal in Patients With Stable IgG4 Related Disease: An Open-labeled Multi-centric Randomized Controlled Study From China Not yet recruiting NCT04124861 Drug free, IS monotherapy and GC combined with IS

Search NIH Clinical Center for Igg4-Related Disease

Genetic Tests for Igg4-Related Disease

Anatomical Context for Igg4-Related Disease

MalaCards organs/tissues related to Igg4-Related Disease:

40
Kidney, Salivary Gland, Skin, Thyroid, Lung, T Cells, Pancreas

Publications for Igg4-Related Disease

Articles related to Igg4-Related Disease:

(show top 50) (show all 2135)
# Title Authors PMID Year
1
IgG4-related disease presenting as a solitary paratesticular fibrous pseudotumor. 61
33552918 2021
2
Clinical and imaging findings suggestive of histopathological immunoglobulin G4-related disease: a single-center retrospective study. 61
32857276 2021
3
Unusual presentation of IgG4-related disease. 61
33759779 2021
4
CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease. 61
33067662 2021
5
IgG4-related disease manifesting as symptoms of appendicitis: Case report and literature review. 61
33460019 2021
6
[A case of IgG4-related disease with initial clinical manifestation of neck lymph nodes enlargement and literature review]. 61
33794639 2021
7
Multiple facial ulcers as a presentation of localized granulomatosis with polyangiitis associated with IgG4-related disease. 61
33259062 2021
8
Histopathological findings in the landscape of IgG4-related pathology in patients with pituitary dysfunction: Review of six cases. 61
33615590 2021
9
Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study. 61
33790306 2021
10
Clinical features and relapse risks of IgG4-related ophthalmic disease: a single-center experience in China. 61
33789746 2021
11
Successful treatment of IgG4-related hypertrophic pachymeningitis with induction rituximab and dexamethasone followed by maintenance rituximab. 61
33768900 2021
12
Rosai-Dorfman disease with infiltration of IgG4-bearing plasma cells presenting as laryngeal-nasal masses and cervical lymphadenopathy: A case report. 61
33761691 2021
13
A Case of IgG4-Related Ophthalmic Disease With Coronary Arteritis. 61
32675723 2021
14
Involvement of Multiple Trigeminal Nerve Branches in IgG4-Related Orbital Disease. 61
32501880 2021
15
An enigmatic case of IgG4-related nephropathy and an updated review of the literature. 61
33683496 2021
16
Hidden IgG4-Related Coronary Disease. 61
33738467 2021
17
Immunoglobulin G4-related systemic disease: mesenteric and peritoneal involvement with radiopathological correlation and differential diagnoses. 61
33742218 2021
18
Vasculitis beyond aortitis in IgG4-related disease (IgG4-RD): case report and review of the literature. 61
32710295 2021
19
IgG4-related disease masquerading as a fungating groin lesion in a patient with HIV and incomplete immune reconstitution. 61
33620878 2021
20
IgG4-related disease presenting as a paraneoplastic syndrome: report of two cases and literature review. 61
33719923 2021
21
Effectiveness and safety of Mizoribine for the treatment of IgG4-related Disease: A Retrospective Cohort Study. 61
33723568 2021
22
Non-immunoglobulin G4-related multifocal fibrosclerosis presenting generalized morphea-like skin lesions. 61
33768547 2021
23
Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease. 61
33775999 2021
24
Ultrasound-guided core needle biopsy compared with open biopsy: a new diagnostic approach to salivary gland enlargement in Sjögren's syndrome? 61
32940706 2021
25
Temporal arteritis in IgG4 related disease. 61
33115666 2021
26
Visual impairment in immunoglobulin G4-related disease: A case report. 61
33500695 2021
27
Emerging therapy options for IgG4-related disease. 61
33689549 2021
28
A Follow-Up Study of a European IgG4-Related Disease Cohort Treated with Rituximab. 61
33807051 2021
29
The Association of Smoking with IgG4-Related Disease: A Case-Control Study. 61
33751033 2021
30
IgG4-related disease of the thyroid gland. 61
33649038 2021
31
IgG4-related Disease – eine radiologische und interdisziplinäre Herausforderung. 61
33772490 2021
32
A Case of IgG4-related Disease With Bone Marrow Involvement: Bone Marrow Findings and Flow Cytometric Immunophenotyping of Plasma Cells. 61
33063688 2021
33
IgG4-related disease: a rare case of isolated cutaneous involvement. 61
32531818 2021
34
IgG4-Related Disease Misdiagnosed as Neoplasm. 61
31880610 2021
35
Imaging of IgG4-related disease in the extracranial head and neck. 61
33524920 2021
36
IgG4-Related Disease of the Skull and Skull Base, A Systematic Review and Report of Two Cases: Review of Skull Base IgG4-Related Disease. 61
33746107 2021
37
Serum free light chain assessment in type 1 autoimmune pancreatitis. 61
33741268 2021
38
IgG4 related disease. 61
33547020 2021
39
Mimic of malignancy: delineating IgG4-related disease and lymphoma. 61
33658213 2021
40
Multiple nodules under the pericardium in a patient with IgG4-related disease. 61
32895746 2021
41
Lymphadenopathy in IgG4-related disease: a phenotype of severe activity and poor prognosis, with eotaxin-3 as a new biomarker. 61
33167029 2021
42
Fibroblast Activation Protein-Targeted PET/CT with 68Ga-FAPI for Imaging IgG4-Related Disease: Comparison to 18F-FDG PET/CT. 61
32513902 2021
43
How specific are elevated IgG4 levels for IgG4-related disease? 61
33541828 2021
44
Efficacy and safety of rituximab biosimilar (CT-P10) in IgG4-related disease: an observational prospective open-label cohort study. 61
33386207 2021
45
Interleukin-35 Promotes Th9 Cell Differentiation in IgG4-Related Disorders: Experimental Data and Review of the Literature. 61
32712804 2021
46
B cell targeted therapy for immunoglobulin G4-related disease. 61
33583344 2021
47
Utility of gastric biopsy in diagnosing IgG4-related gastrointestinal disease. 61
33378576 2021
48
Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to greater systemic disease activity due to multi-organ involvement in IgG4-related dacryoadenitis/sialadenitis. 61
33491522 2021
49
Reactive Eosinophil Proliferations in Tissue and the Lymphocytic Variant of Hypereosinophilic Syndrome. 61
33367482 2021
50
IgG4-related disease and ANCA positive vasculitis in childhood: a case-based review. 61
33590421 2021

Variations for Igg4-Related Disease

Expression for Igg4-Related Disease

Search GEO for disease gene expression data for Igg4-Related Disease.

Pathways for Igg4-Related Disease

Pathways related to Igg4-Related Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 TNFSF13B TLR7 PHB PDCD1 LGALS3 IL4
2
Show member pathways
13.38 TNFSF13B NR3C1 IL4 IL33 IFNA1 GDF15
3
Show member pathways
12.51 TNFSF13B IL4 IFNA1 ICOSLG AICDA
4 11.74 TNFSF13B TLR7 PDCD1 LGALS3 IL4 IFNA1
5 11.71 TNFSF13B LGALS3 IL4
6 11.48 IL4 IL33 CCR6
7 11.3 IL4 CCL17 AICDA
8 11.17 TNFSF13B PDCD1 IL4 ICOSLG CCR6
9 10.99 IL4 IL33 CCL17

GO Terms for Igg4-Related Disease

Cellular components related to Igg4-Related Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TNFSF13B LGALS3 IL4 IL33 IFNA1 GDF15
2 extracellular region GO:0005576 9.28 TNFSF13B PLA2R1 LGALS3 IL4 IL33 IFNA1

Biological processes related to Igg4-Related Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.88 TNFSF13B TLR7 PDCD1 MARCO LGALS3 ICOSLG
2 immune response GO:0006955 9.85 TNFSF13B TLR7 IL4 CCR6 CCL17
3 defense response to virus GO:0051607 9.73 TLR7 IL33 IFNA1 AICDA
4 B cell differentiation GO:0030183 9.65 IL4 IFNA1 AICDA
5 positive regulation of myoblast fusion GO:1901741 9.52 IL4 GDF15
6 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 IL4 IL33
7 humoral immune response GO:0006959 9.5 PDCD1 IFNA1 CCR6
8 positive regulation of interleukin-13 production GO:0032736 9.49 IL4 IL33
9 T cell costimulation GO:0031295 9.43 TNFSF13B PDCD1 ICOSLG
10 positive regulation of mononuclear cell migration GO:0071677 9.37 LGALS3 IL4
11 signal transduction GO:0007165 9.28 TNFSF13B TLR7 PHB NR3C1 IL4 IFNA1
12 B cell costimulation GO:0031296 9.16 TNFSF13B IL4
13 B cell activation GO:0042113 9.13 PHB IL4 ICOSLG

Molecular functions related to Igg4-Related Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNFSF13B IL4 IL33 IFNA1 GDF15 CCL17
2 pattern recognition receptor activity GO:0038187 8.96 TLR7 MARCO

Sources for Igg4-Related Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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