MCID: IGG015
MIFTS: 22

Igg4-Related Thyroid Disease

Categories: Bone diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Igg4-Related Thyroid Disease

MalaCards integrated aliases for Igg4-Related Thyroid Disease:

Name: Igg4-Related Thyroid Disease 58
Riedel's Thyroiditis 71
Riedel Thyroiditis 58
Riedel Disease 58

Characteristics:

Orphanet epidemiological data:

58
igg4-related thyroid disease
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 33 E06.5
UMLS via Orphanet 72 C0154162
Orphanet 58 ORPHA64744
UMLS 71 C0154162

Summaries for Igg4-Related Thyroid Disease

MalaCards based summary : Igg4-Related Thyroid Disease, also known as riedel's thyroiditis, is related to fibrosis of extraocular muscles, congenital, 1 and multinodular goiter. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lung.

Related Diseases for Igg4-Related Thyroid Disease

Diseases related to Igg4-Related Thyroid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 fibrosis of extraocular muscles, congenital, 1 10.2
2 multinodular goiter 10.2
3 igg4-related disease 10.2
4 dysphagia 10.2
5 hypoparathyroidism 10.1
6 graves' disease 10.1
7 follicular adenoma 10.1
8 adenoma 10.1
9 mediastinitis 10.1
10 dacryoadenitis 10.1
11 fibrosing mediastinitis 10.1
12 retroperitoneal fibrosis 10.1
13 goiter 10.0
14 hashimoto thyroiditis 9.9
15 thyroiditis 9.9

Graphical network of the top 20 diseases related to Igg4-Related Thyroid Disease:



Diseases related to Igg4-Related Thyroid Disease

Symptoms & Phenotypes for Igg4-Related Thyroid Disease

Drugs & Therapeutics for Igg4-Related Thyroid Disease

Drugs for Igg4-Related Thyroid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3 Immunoglobulin G Phase 1, Phase 2
4 Antirheumatic Agents Phase 1, Phase 2
5 Immunoglobulins Phase 1, Phase 2
6 Immunologic Factors Phase 1, Phase 2
7 Antibodies Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab

Search NIH Clinical Center for Igg4-Related Thyroid Disease

Genetic Tests for Igg4-Related Thyroid Disease

Anatomical Context for Igg4-Related Thyroid Disease

MalaCards organs/tissues related to Igg4-Related Thyroid Disease:

40
Thyroid, Bone, Lung, Kidney, Prostate, B Cells, Trachea

Publications for Igg4-Related Thyroid Disease

Articles related to Igg4-Related Thyroid Disease:

(show top 50) (show all 227)
# Title Authors PMID Year
1
Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases. 61
31434818 2019
2
IgG4-Related Disease of the Thyroid Gland Requiring Emergent Total Thyroidectomy: A Case Report. 61
29855801 2019
3
DIAGNOSIS OF ENDOCRINE DISEASE: IgG4-related thyroid autoimmune disease. 61
30889549 2019
4
MOLECULAR-BIOLOGICAL THYROID PROFILE DURING AUTOIMMUNE DISEASE - HASHIMOTO AND RIEDEL'S THYROIDITIS. 61
31322526 2019
5
Difficulties in diagnosis of Riedel's thyroiditis on aspiration cytology: A case report and brief review of the literature. 61
30589235 2019
6
Riedel's Thyroiditis: Report of Two Cases and Literature Review. 61
31929916 2019
7
Letter to the editor on "Vasovagal reflex emergency caused by Riedel's thyroiditis: A case report and review of the literature". Lymphocytic thyroiditis with multifocal non-tumor-associated psammoma bodies. 61
29804708 2018
8
Riedel's thyroiditis: clinical presentation, treatment and outcomes. 61
29380231 2018
9
Rituximab: a novel treatment for refractory Riedel's thyroiditis. 61
29472985 2018
10
Does the Intensity of IGG4 Immunostaining Have a Correlation with the Clinical Presentation of Riedel's Thyroiditis? 61
29850288 2018
11
Painful Hashimoto's thyroiditis: myth or reality? 61
28337674 2017
12
Riedel's thyroiditis association with IgG4-related disease. 61
27647429 2017
13
Clinical Features of Patients with Basedow's Disease and High Serum IgG4 Levels. 61
28458304 2017
14
[Recent advance of IgG4 related thyroid disease]. 61
28072985 2017
15
Severe trachea compression caused by Riedel's thyroiditis: A case report and review of the literature. 61
27833746 2016
16
Clinical Update in Aspects of the Management of Autoimmune Thyroid Diseases. 61
28029020 2016
17
Immunoglobulin G4-Related Thyroid Diseases. 61
28101487 2016
18
Riedel's Thyroiditis Mimicking as Anaplastic Thyroid Carcinoma: Unusual Presentation. 61
27651702 2016
19
Riedel's thyroiditis. 61
27594944 2016
20
[IgG4-related Riedel's thyroiditis]. 61
26961404 2016
21
Riedel's thyroiditis in a black African: A case report and review of literature. 61
27251976 2016
22
A CASE OF RIEDEL'S THYROIDITIS. 61
31149111 2016
23
A small subgroup of Hashimoto's thyroiditis is associated with IgG4-related disease. 61
26669779 2016
24
Vasovagal reflex emergency caused by Riedel's thyroiditis: A case report and review of the literature. 61
23644007 2016
25
Immunoglobulin G4 related thyroid disorders: Diagnostic challenges and clinical outcomes. 61
27828690 2016
26
Early Hypoparathyroidism Reversibility with Treatment of Riedel's Thyroiditis. 61
26200816 2015
27
Overlapping Morphologic and Immunohistochemical Features of Hashimoto Thyroiditis and IgG4-Related Thyroid Disease. 61
25898816 2015
28
Riedel's Thyroiditis with Intense FDG Uptake Demonstrated on FDG PET/CT. 61
25800596 2015
29
A Case Report Demonstrating How the Clinical Presentation of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma Can Mimic Benign Riedel's Thyroiditis. 61
26137328 2015
30
Clinicopathological features of Riedel's thyroiditis associated with IgG4-related disease in Japan. 61
26052139 2015
31
Riedel's Thyroiditis in an Elderly Male Patient: A Rare Entity. 61
25478360 2014
32
Increased lymphangiogenesis in Riedel thyroiditis (Immunoglobulin G4-related thyroid disease). 61
25011997 2014
33
IgG4-related disease: a new kid on the block or an old aquaintance? 61
25360299 2014
34
Elevated serum immunoglobulin G4 levels in patients with Graves' disease and their clinical implications. 61
24256421 2014
35
IgG4-related disease. 61
23849464 2014
36
Mucosa-associated lymphoid tissue lymphoma of the thyroid with abundant IgG4-positive plasma cells. 61
23395549 2013
37
Prolonged hypocalcaemia after pamidronate infusion in Riedel's thyroiditis associated hypoparathyroidism. 61
24127509 2013
38
Novel use of rituximab in a case of Riedel's thyroiditis refractory to glucocorticoids and tamoxifen. 61
23824414 2013
39
Fatal neck necrotizing cellulitis in a patient with Riedel's thyroiditis. 61
23528162 2013
40
Riedel thyroiditis in a patient with graves disease. 61
24396668 2013
41
Case of concurrent Riedel's thyroiditis, acute suppurative thyroiditis, and micropapillary carcinoma. 61
23526581 2013
42
[Thyroiditis]. 61
23513772 2013
43
Atypical Presentation of Riedel's Thyroiditis: Multifocal Nodular Fibrosis and Resolution with Levothyroxine. 61
24783028 2013
44
A misdiagnosed Riedel's thyroiditis successfully treated by thyroidectomy and tamoxifen. 61
23265752 2012
45
Nodular sclerosing Hodgkin's disease mimicking Riedel's invasive fibrous thyroiditis. 61
22841568 2012
46
A case of asymptomatic riedel thyroiditis with follicular adenoma in a patient with a multinodular goiter: an unusual association. 61
24783021 2012
47
Riedel's thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease? 61
22827716 2012
48
Subclinical Riedel's thyroiditis with hypothyroidism coexisting with Mikulicz's disease. 61
21833525 2012
49
[Indications for surgery in thyroiditis]. 61
22844832 2012
50
A case of Riedel's thyroiditis. 61
22563540 2012

Variations for Igg4-Related Thyroid Disease

Expression for Igg4-Related Thyroid Disease

Search GEO for disease gene expression data for Igg4-Related Thyroid Disease.

Pathways for Igg4-Related Thyroid Disease

GO Terms for Igg4-Related Thyroid Disease

Sources for Igg4-Related Thyroid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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