Aliases & Classifications for Ileitis

MalaCards integrated aliases for Ileitis:

Name: Ileitis 12 54 43 15 71
Crohn's Ileitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060189
MeSH 43 D007079
NCIt 49 C84782
SNOMED-CT 67 52457000
ICD10 32 K52.9
UMLS 71 C0020877

Summaries for Ileitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in ileum, has symptom diarrhea, has symptom abdominal pain, often in the right lower quadrant, has symptom weight loss.

MalaCards based summary : Ileitis, also known as crohn's ileitis, is related to crohn's disease and pouchitis, and has symptoms including abdominal pain, weight loss and diarrhea. An important gene associated with Ileitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clofazimine and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include ileum, small intestine and colon, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 74 Ileitis is an inflammation of the ileum, a portion of the small intestine. Crohn's ileitis is a type of... more...

Related Diseases for Ileitis

Diseases related to Ileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 523)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 32.5 TNF TLR5 TLR4 TLR2 NOD2 IL6
2 pouchitis 31.6 TLR4 NOD2
3 diarrhea 31.2 TNF TLR4 MPO IL6
4 crohn's colitis 31.1 TNF NOD2 DEFB103A CCR6
5 appendicitis 31.0 TNF TLR4 MPO IL6 IL17A
6 ileus 30.9 TNF IL6 IL17A CSF2
7 intestinal perforation 30.8 NOD2 IL6 FABP2
8 spondylarthropathy 30.8 TNF TLR4 TLR2 NOD2
9 brucellosis 30.7 TNF TLR4 IL6 IL17A
10 cytomegalovirus infection 30.7 TNF IL6 CCL5
11 diverticulitis 30.7 TNF IL6 CCR6
12 cystitis 30.6 TNF TLR4 IL6 IL17A
13 vasculitis 30.6 TNF MPO IL6 IL17A
14 lymphadenitis 30.6 TNF TLR4 SOCS3 NOD2 CCR6
15 hypereosinophilic syndrome 30.6 MPO CSF2 CCR3 CCL5
16 spondyloarthropathy 30.6 TNF IL6 IL17A
17 peritonitis 30.5 TNF TLR4 TLR2 MPO IL6 CCL5
18 pulmonary tuberculosis 30.4 TNF TLR4 TLR2 IL6 IL17A
19 sarcoidosis 1 30.4 TNF NOD2 CCR6 CCR5 CCL5
20 herpes zoster 30.4 TNF TLR2 CCR5
21 spondylitis 30.3 TNF NOD2 IL6 IL17A CCR6
22 ulcerative colitis 30.3 TNF TLR5 TLR4 NOD2 MPO IL6
23 typhoid fever 30.3 TNF TLR5 TLR4 IL6 CCR6
24 gastritis 30.3 TNF TLR4 IL6 IL17A CCR6 CCL5
25 kaposi sarcoma 30.3 IL6 CSF2 CCR5 CCR3
26 familial mediterranean fever 30.3 TNF TLR4 TLR2 NOD2 IL6 IL17A
27 esophagitis 30.3 TNF IL6 CCR3
28 pyoderma 30.2 TNF NOD2 CCR6
29 autoimmune gastritis 30.2 TNF IL6 CCR6
30 pyoderma gangrenosum 30.2 TNF NOD2 CCR6
31 spondyloarthropathy 1 30.2 TNF TLR4 NOD2 IL17A CCR6
32 contact dermatitis 30.2 TNF TLR4 TLR2 IL6 IL17A
33 plague 30.2 TNF TLR5 TLR4 TLR2 IL6 CCR5
34 uveitis 30.2 TNF NOD2 IL6 IL17A CCR5
35 proteasome-associated autoinflammatory syndrome 1 30.1 TNF TLR4 TLR2 MPO IL6 IL17A
36 exanthem 30.1 TNF IL6 CSF2 CCR6
37 sclerosing cholangitis 30.0 TNF TLR4 NOD2 MPO MADCAM1 IL6
38 mycobacterium tuberculosis 1 30.0 TNF TLR4 TLR2 NOD2 IL17A CCR6
39 chlamydia 30.0 TNF TLR4 TLR2 IL6 IL17A CSF2
40 dysentery 30.0 TNF TLR4 TLR2 IL6 CCR6
41 cholangitis 29.9 TNF TLR4 NOD2 MPO MADCAM1 IL6
42 colitis 29.8 TNF TLR5 TLR4 TLR2 NOD2 MPO
43 peripheral nervous system disease 29.8 TNF TLR4 TLR2 IL6 IL17A CCR6
44 thrombocytopenia 29.7 TNF TLR5 TLR4 TLR2 IL6 IL17A
45 acquired immunodeficiency syndrome 29.7 TNF MADCAM1 IL6 CSF2 CCR6 CCR5
46 allergic hypersensitivity disease 29.7 TNF TLR4 TLR2 IL17A CSF2 CCR6
47 cholangitis, primary sclerosing 29.7 TNF NOD2 MPO MADCAM1 IL6 CCR9
48 psoriatic arthritis 29.6 TNF TLR4 TLR2 NOD2 IL6 IL17A
49 schistosomiasis 29.5 TNF IL17A CCL5
50 autoimmune disease 29.5 TNF IL6 IL17A CSF2 CCR6 CCR5

Graphical network of the top 20 diseases related to Ileitis:



Diseases related to Ileitis

Symptoms & Phenotypes for Ileitis

Symptoms:

12
  • abdominal pain
  • weight loss
  • diarrhea

MGI Mouse Phenotypes related to Ileitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.3 CCL25 CCL5 CCR3 CCR5 CCR6 CCR9
2 digestive/alimentary MP:0005381 10.21 CCL25 CCR5 CCR9 IL17A IL6 NOD2
3 homeostasis/metabolism MP:0005376 10.2 CCR3 CCR5 CCR6 CSF2 FABP2 IL17A
4 immune system MP:0005387 10.19 CCL25 CCL5 CCR3 CCR5 CCR6 CCR9
5 adipose tissue MP:0005375 10.18 CCL25 CSF2 FABP2 IL6 RETNLB SOCS3
6 growth/size/body region MP:0005378 10.18 CCL25 CSF2 FABP2 IL17A IL6 NOD2
7 cardiovascular system MP:0005385 10.16 CCR5 CCR6 CSF2 IL6 MPO SOCS3
8 liver/biliary system MP:0005370 9.81 CCR5 FABP2 IL6 RETNLB SOCS3 TLR2
9 neoplasm MP:0002006 9.5 CCR5 CSF2 IL6 RETNLB TLR2 TLR4
10 respiratory system MP:0005388 9.28 CCR3 CSF2 IL17A IL6 SOCS3 TLR2

Drugs & Therapeutics for Ileitis

Drugs for Ileitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Rifabutin Approved, Investigational Phase 4 72559-06-9 6323490 46783538
4 Anti-Inflammatory Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Cytochrome P-450 CYP3A Inhibitors Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Antitubercular Agents Phase 4
10 Anti-Bacterial Agents Phase 4
11
Adalimumab Approved Phase 3 331731-18-1 16219006
12
Mercaptopurine Approved Phase 3 50-44-2 667490
13 Antirheumatic Agents Phase 3
14 Antimetabolites Phase 3
15 Immunosuppressive Agents Phase 3
16
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
17 Immunologic Factors Phase 1
18 Antibodies, Monoclonal Phase 1
19 Antibodies Phase 1
20 Immunoglobulins Phase 1
21
Infliximab Approved 170277-31-3
22
Glucosamine Approved, Investigational 3416-24-8 439213
23 Gastrointestinal Agents
24 Dermatologic Agents

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
2 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
3 An Investigator Initiated Prospective, Single Center, Randomized, Open Label Study to Assess the Efficacy of Adalimumab for the Maintenance of Remission in Post-operative CD Patients Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
4 Diagnosis of Intraepithelial Neoplasia in Patients With Long Standing Ulcerative Colitis With Chromoscopic Guided Endomicroscopy Completed NCT00352404 Phase 3
5 A Multicentre Australian Phase 2 Study to Evaluate Safety and Efficacy of Mesenchymal Stromal Cells for Treating Biologic Refractory Crohn's Disease Completed NCT01090817 Phase 2 Mesenchymal stromal cells (MSC) for infusion
6 A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study to Evaluate Efficacy and Safety of Oral BT-11 in Moderate to Severe Crohn's Disease Not yet recruiting NCT03870334 Phase 2 BT-11 1,000 mg;Placebo
7 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
8 A Multi-Center, Phase 1, Open-Label Evaluation Of The Effect Of PF-00547659 (Anti Madcam Monoclonal Antibody) On Cerebrospinal Fluid (CSF) Lymphocytes In Volunteers With Crohns Disease Or Ulcerative Colitis Who Are Anti-TNFInadequate Responders (TOSCA) Completed NCT01387594 Phase 1 lumbar puncture
9 Mucosal Gene Expression Defects in Patients With Inflammatory Bowel Disease Before and After First Infliximab Therapy Completed NCT00639821
10 Predictors of Tissue Healing in Inflammatory Bowel Disease Patients Treated With Anti-TNF Completed NCT01605175
11 Predictors of Non-response and Loss of Response in IBD Patients Treated With Anti-TNF. Completed NCT01605188
12 Prospective Randomized Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis in the Prevention of Post-operative Recurrence of Crohn's Disease Recruiting NCT03256240
13 Combined PET-MRI in the Diagnostics of Chronic Inflammatory Bowel Diseases (IBD)- a Feasibility Study Recruiting NCT02364973
14 A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Crohn's Disease Not yet recruiting NCT04100005
15 99mTc-labelled D-Glucosamine in the Evaluation of Disease Activity in Patients With Degenerative and Inflammatory Rheumatic Conditions No longer available NCT01789151
16 Phase III Study Comparing 3D Conformal Radiotherapy and Conformal Radiotherapy IMRT to Treat Endometrial Cancer of 70 Years Old Women : Contribution of Oncogeriatric Evaluation to the Study of Acute Toxicity Terminated NCT01641497
17 Comparing the Quality of Life of Terminal Ileitis Patients With Crohn's Disease Treated With Anti-TNF or Surgical Resection Withdrawn NCT02872506 Anti TNF

Search NIH Clinical Center for Ileitis

Cochrane evidence based reviews: ileitis

Genetic Tests for Ileitis

Anatomical Context for Ileitis

The Foundational Model of Anatomy Ontology organs/tissues related to Ileitis:

19
Ileum

MalaCards organs/tissues related to Ileitis:

40
Small Intestine, Colon, T Cells, Liver, Testes, Neutrophil, Bone

Publications for Ileitis

Articles related to Ileitis:

(show top 50) (show all 2090)
# Title Authors PMID Year
1
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease. 61 54
19079235 2008
2
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. 61 54
16682432 2006
3
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease. 61 54
16401463 2006
4
Carriage of CARD15 variants and smoking as risk factors for resective surgery in patients with Crohn's ileal disease. 54 61
16167972 2005
5
L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. 54 61
15699171 2005
6
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. 54 61
14570728 2003
7
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. 54 61
12706472 2003
8
Anti-inflammatory agents and substance P depletion in experimental ileitis. 54 61
18475536 1993
9
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn's Disease-Like Inflammation. 61
31276162 2020
10
Histologic Healing is More Strongly Associated with Clinical Outcomes in Ileal Crohn's Disease than Endoscopic Healing. 61
31812654 2019
11
Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn's-Like Ileitis by Suppressing Thymocyte Maturation. 61
31807751 2019
12
Serum Concentrations of 7α-hydroxy-4-cholesten-3-one Are Associated With Bile Acid Diarrhea in Patients With Crohn's Disease. 61
30448597 2019
13
Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases? 61
31009791 2019
14
Neutralization of IL-1α ameliorates Crohn's disease-like ileitis by functional alterations of the gut microbiome. 61
31843928 2019
15
Is Crohn's disease a rightly used eponym? 61
31701137 2019
16
Human Gut Microbiome Transplantation in Ileitis Prone Mice: A Tool for the Functional Characterization of the Microbiota in Inflammatory Bowel Disease Patients. 61
31750921 2019
17
Small bowel perforation secondary to CMV-positive terminal ileitis postrenal transplant. 61
31772132 2019
18
[Pediatric colonoscopy findings and changing patterns from Beijing in one institutional experience over 12 years]. 61
31624383 2019
19
[Purulent peritonitis due to gonococcal infection]. 61
31647617 2019
20
Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn's disease: the LIR!C Trial. 61
31233395 2019
21
Bacillus pumilus probiotic feed supplementation mitigates Lawsonia intracellularis shedding and lesions. 61
31640784 2019
22
Behçet's disease; A rare refractory patient with vena cava superior syndrome treated with infliximab: a case report and review of the literature. 61
30220250 2019
23
Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota. 61
31325428 2019
24
Intestinal Perforation Due to Crohn's Ileitis Immunosuppression Related Lymphoma and Meckel's Diverticulum. 61
29730434 2019
25
Effects of thermized donkey milk with lysozyme activity on altered gut barrier in mice exposed to water-avoidance stress. 61
31326167 2019
26
Lymphomatoid Papulosis Type B in a Patient with Crohn's Disease Treated with TNF-Alpha Inhibitors Infliximab and Adalimumab. 61
31542070 2019
27
Primary Sclerosing Cholangitis in Children With Inflammatory Bowel Diseases Is Associated With Milder Clinical Activity But More Frequent Subclinical Inflammation and Growth Impairment. 61
31493578 2019
28
Is the presence of echo-rich periportal cuffing in the liver indicator for abdominal inflammation in pediatric patients? 61
31476200 2019
29
Hepatic portal venous gas associated with Klebsiella oxytoca infection in the absence of preceding antibiotic treatment. 61
30739249 2019
30
The Incidence and Definition of Crohn's Disease of the Pouch: A Systematic Review and Meta-analysis. 61
30698715 2019
31
Characteristics and outcome of primary sclerosing cholangitis associated with inflammatory bowel disease in Asian children. 61
31409456 2019
32
Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography. 61
31433363 2019
33
Terminal ileum ileoscopy and histology in patients undergoing high-definition colonoscopy with virtual chromoendoscopy for chronic nonbloody diarrhea: A prospective, multicenter study. 61
31428422 2019
34
Idiopathic ischaemic ileitis, with overt obscure digestive bleeding. 61
30455040 2019
35
Dietary emulsifier polysorbate-80-induced small-intestinal vulnerability to indomethacin-induced lesions via dysbiosis. 61
31359491 2019
36
Small bowel capsule endoscopy in ulcerative colitis: the capcolitis study: a prospective observational study. 61
31082999 2019
37
Abdominal Lymphoma Presenting as Terminal Ileitis: A Case Report. 61
31003819 2019
38
Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. 61
31232887 2019
39
A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine. 61
31312282 2019
40
Microscopic/"Backwash" Ileitis and Its Association With Colonic Disease in New Onset Pediatric Ulcerative Colitis. 61
31124991 2019
41
BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway. 61
30753547 2019
42
Phenotypic variation in paediatric IBD by age: a multi-centre prospective inception cohort study of the Canadian Children IBD Network. 61
31136648 2019
43
The use of fecal calprotectin in monitoring activity of inflammatory bowel diseases. 61
31094477 2019
44
Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation. 61
30948141 2019
45
Role of colonoscopy in diagnosis of capecitabine associated ileitis: Two case reports. 61
31205599 2019
46
Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. 61
31132747 2019
47
Efficacy of a novel inactivated Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions. 61
30867100 2019
48
Treatment of Active Crohn's Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition. 61
30550821 2019
49
IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. 61
30700427 2019
50
Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn's disease: comparison with magnetic resonance enterography. 61
30962408 2019

Variations for Ileitis

Expression for Ileitis

Search GEO for disease gene expression data for Ileitis.

Pathways for Ileitis

Pathways related to Ileitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR5 TLR4 TLR2 SOCS3 NOD2
2
Show member pathways
13.85 TNF IL6 IL17A CSF2 CCR9 CCR6
3
Show member pathways
13.67 TNF TLR4 SOCS3 IL6 IL17A CSF2
4
Show member pathways
13.38 TNF SOCS3 NOD2 IL6 IL17A CSF2
5
Show member pathways
13.29 TNF IL6 IL17A CSF2 CCR9 CCR6
6
Show member pathways
13.15 TNF TLR5 TLR4 TLR2 SOCS3 NOD2
7
Show member pathways
12.95 TNF TLR4 TLR2 IL6 CSF2 CCR5
8
Show member pathways
12.92 TNF TLR5 TLR4 TLR2 IL6 IL17A
9
Show member pathways
12.91 CCR9 CCR6 CCR5 CCR3 CCL5 CCL25
10
Show member pathways
12.88 TNF MADCAM1 IL6 IL17A CCR9 CCL25
11
Show member pathways
12.85 TNF TLR4 TLR2 SOCS3 IL6 CCL5
12 12.8 TNF TLR2 SOCS3 IL6 CCL5
13
Show member pathways
12.72 TNF TLR5 TLR4 TLR2 IL6
14
Show member pathways
12.62 TNF SOCS3 MPO IL6 IL17A
15
Show member pathways
12.62 TNF TLR4 TLR2 IL6 IL17A CSF2
16 12.61 TNF TLR2 SOCS3 MPO IL17A CCL5
17
Show member pathways
12.46 TNF TLR5 TLR4 TLR2 SOCS3 NOD2
18 12.42 TNF TLR5 TLR4 CSF2 CCL5
19
Show member pathways
12.38 TNF TLR5 TLR2 IL6 IL17A CSF2
20
Show member pathways
12.34 TNF MPO IL6 CCL5
21 12.31 TNF TLR5 TLR4 IL6
22
Show member pathways
12.31 TNF TLR5 TLR4 TLR2 IL6
23 12.29 TNF TLR4 TLR2 NOD2 IL6
24
Show member pathways
12.27 TNF TLR4 TLR2 CCR5
25 12.25 TNF TLR4 NOD2 IL6 DEFB103A CCL5
26
Show member pathways
12.24 TNF TLR5 TLR2 IL6
27 12.24 TNF TLR5 TLR4 TLR2 IL6
28
Show member pathways
12.24 TNF TLR5 TLR4 TLR2 IL6
29
Show member pathways
12.1 TNF TLR4 TLR2 IL6 CSF2
30
Show member pathways
12.09 TNF IL6 CCR9 CCR6 CCR5 CCR3
31 12.05 TNF MPO IL6 CSF2 CCR3
32 12.02 TNF SOCS3 IL6 IL17A
33
Show member pathways
12.02 TNF TLR5 TLR4 TLR2 IL6 IL17A
34 11.98 TNF TLR4 TLR2 IL6 CSF2
35
Show member pathways
11.92 TLR4 IL6 IL17A CSF2
36 11.89 TNF SOCS3 NOD2 IL6 CSF2 CCL5
37 11.85 TLR5 TLR4 IL6 CSF2
38 11.82 TLR5 TLR4 TLR2
39 11.79 TNF IL17A CCR6
40 11.77 TNF TLR4 IL6
41 11.75 TNF IL6 CSF2
42
Show member pathways
11.68 TNF IL6 CSF2
43 11.67 TNF IL6 CSF2 CCR3 CCL5
44 11.61 TNF TLR4 TLR2 IL6
45 11.61 TNF TLR5 TLR4 TLR2 IL6
46 11.59 TNF RETNLB IL6 IL17A CSF2 CCL5
47 11.55 TNF TLR4 TLR2
48 11.54 TNF MPO IL6
49 11.49 TNF IL6 CSF2 CCR5 CCL5
50 11.43 TNF TLR4 SOCS3 IL6

GO Terms for Ileitis

Cellular components related to Ileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TNF RETNLB MPO IL6 IL17A DEFB103A
2 cell GO:0005623 9.87 MPO IL6 CCR9 CCR6 CCR5 CCR3
3 integral component of plasma membrane GO:0005887 9.86 TNF TLR5 TLR4 TLR2 CCR9 CCR6
4 extracellular space GO:0005615 9.81 TNF RETNLB MPO IL6 IL17A DEFB103A
5 cell surface GO:0009986 9.5 TNF TLR4 TLR2 NOD2 CCR9 CCR6
6 external side of plasma membrane GO:0009897 9.17 TNF TLR4 IL17A CCR9 CCR6 CCR5

Biological processes related to Ileitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.3 TLR5 TLR4 TLR2 RETNLB MADCAM1 IL6
2 positive regulation of gene expression GO:0010628 10.09 TNF TLR4 TLR2 IL6 CSF2
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.02 TNF TLR4 NOD2 CCL5 CCL25
4 defense response to bacterium GO:0042742 10.02 TNF TLR5 TLR4 NOD2 MPO DEFB103A
5 MAPK cascade GO:0000165 10.01 TNF CSF2 CCR5 CCL5
6 cytokine-mediated signaling pathway GO:0019221 10 TNF SOCS3 IL6 IL17A CSF2 CCR5
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.98 CCR9 CCR6 CCR5 CCR3
8 defense response GO:0006952 9.98 TNF NOD2 MPO DEFB103A CCR5
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR4 TLR2 NOD2 IL6
10 defense response to Gram-positive bacterium GO:0050830 9.95 TNF TLR2 IL6 DEFB103A
11 cellular response to lipopolysaccharide GO:0071222 9.95 TNF TLR5 TLR4 NOD2 IL6 CSF2
12 cellular response to interferon-gamma GO:0071346 9.93 TLR4 TLR2 CCL5 CCL25
13 calcium-mediated signaling GO:0019722 9.92 CCR9 CCR6 CCR5 CCR3
14 chemotaxis GO:0006935 9.91 DEFB103A CCR9 CCR6 CCR5 CCR3 CCL5
15 positive regulation of inflammatory response GO:0050729 9.9 TNF TLR4 TLR2
16 positive regulation of JNK cascade GO:0046330 9.89 TNF TLR4 NOD2
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TNF TLR4 TLR2 NOD2
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.89 TNF SOCS3 IL6 CSF2 CCL5
19 cellular response to interleukin-1 GO:0071347 9.88 IL17A CCL5 CCL25
20 regulation of inflammatory response GO:0050727 9.88 TNF TLR4 NOD2
21 cellular response to organic cyclic compound GO:0071407 9.87 TNF NOD2 CCL5
22 cellular defense response GO:0006968 9.87 CCR9 CCR6 CCR5 CCR3
23 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 TNF IL6 CCL5
24 humoral immune response GO:0006959 9.86 TNF IL6 CCR6
25 positive regulation of tumor necrosis factor production GO:0032760 9.86 TLR4 TLR2 NOD2
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 TNF TLR5 TLR4
27 monocyte chemotaxis GO:0002548 9.85 IL6 CCL5 CCL25
28 toll-like receptor signaling pathway GO:0002224 9.84 TLR5 TLR4 TLR2
29 positive regulation of interleukin-6 secretion GO:2000778 9.84 TNF TLR4 TLR2 IL17A
30 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.83 TLR5 TLR4 TLR2
31 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 CCL5
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF TLR4 TLR2 CCL5
33 positive regulation of interleukin-6 production GO:0032755 9.83 TNF TLR4 TLR2 NOD2 IL6
34 positive regulation of interleukin-10 production GO:0032733 9.8 TLR4 TLR2 NOD2
35 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.79 TLR4 NOD2 IL17A
36 dendritic cell chemotaxis GO:0002407 9.78 CCR6 CCR5 CCL5
37 positive regulation of chemokine production GO:0032722 9.78 TNF TLR4 TLR2 IL6
38 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.77 TLR4 TLR2 NOD2
39 chemokine-mediated signaling pathway GO:0070098 9.73 CCR9 CCR6 CCR5 CCR3 CCL5 CCL25
40 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL6
41 positive regulation of podosome assembly GO:0071803 9.72 TNF CSF2
42 positive regulation of interleukin-8 production GO:0032757 9.72 TNF TLR5 TLR4 TLR2 NOD2
43 regulation of cytokine secretion GO:0050707 9.71 TLR5 TLR2
44 I-kappaB phosphorylation GO:0007252 9.71 TLR4 TLR2
45 macrophage activation GO:0042116 9.7 TLR4 CSF2
46 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2
47 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
48 cell chemotaxis GO:0060326 9.7 DEFB103A CCR9 CCR6 CCR5 CCR3 CCL5
49 negative regulation of macrophage apoptotic process GO:2000110 9.69 NOD2 CCR5 CCL5
50 positive regulation of interleukin-23 production GO:0032747 9.68 IL17A CSF2

Molecular functions related to Ileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.8 TNF IL6 IL17A CSF2 CCL5 CCL25
2 chemokine binding GO:0019956 9.56 CCR9 CCR6 CCR5 CCR3
3 C-C chemokine binding GO:0019957 9.46 CCR9 CCR6 CCR5 CCR3
4 chemokine receptor binding GO:0042379 9.4 CCL5 CCL25
5 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
6 C-C chemokine receptor activity GO:0016493 9.26 CCR9 CCR6 CCR5 CCR3
7 chemokine receptor activity GO:0004950 8.92 CCR9 CCR6 CCR5 CCR3

Sources for Ileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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