Aliases & Classifications for Ileitis

MalaCards integrated aliases for Ileitis:

Name: Ileitis 12 55 44 15 73
Crohn's Ileitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060189
ICD10 33 K52.9
MeSH 44 D007079
NCIt 50 C84782
SNOMED-CT 68 52457000
UMLS 73 C0020877

Summaries for Ileitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in ileum, has symptom diarrhea, has symptom abdominal pain, often in the right lower quadrant, has symptom weight loss.

MalaCards based summary : Ileitis, also known as crohn's ileitis, is related to pouchitis and colitis, and has symptoms including abdominal pain, weight loss and diarrhea. An important gene associated with Ileitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Clarithromycin and Rifabutin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 76 Ileitis is an inflammation of the ileum, a portion of the small intestine. Crohn''s ileitis is a type of... more...

Related Diseases for Ileitis

Diseases related to Ileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 pouchitis 30.7 NOD2 TLR4
2 colitis 30.6 IL17A IL6 MPO NOD2 TLR4 TNF
3 ileocolitis 30.5 NOD2 TNF
4 ulcerative colitis 30.5 IL17A IL6 MPO NOD2 TLR4 TNF
5 mesenteric lymphadenitis 30.4 IL6 NOD2 TLR2
6 lymphadenitis 30.4 NOD2 TLR4 TNF
7 crohn's colitis 30.3 NOD2 TNF
8 appendicitis 30.2 IL6 MPO TNF
9 cystitis 30.1 IL6 TLR4 TNF
10 acquired immunodeficiency syndrome 29.9 CSF2 IL6 TNF
11 peritonitis 29.9 IL6 MPO TLR2 TNF
12 autoimmune gastritis 29.8 IL6 TNF
13 spondyloarthropathy 1 29.7 IL17A NOD2 TLR4 TNF
14 chlamydia 29.7 IL6 TLR2 TLR4 TNF
15 spondylitis 29.7 IL17A IL6 NOD2 TNF
16 typhoid fever 29.7 IL6 TLR4 TLR5 TNF
17 gastrointestinal system disease 29.6 IL17A IL6 NOD2 TLR4 TNF
18 inflammatory bowel disease 29.4 IL17A IL6 MPO NOD2 TLR2 TLR4
19 arthritis 29.4 CSF2 IL17A IL6 NOD2 TNF
20 systemic lupus erythematosus 29.3 IL17A IL6 MPO TLR2 TLR4 TLR5
21 crohn's disease 11.7
22 purpura 10.3
23 scorpion envenomation 10.2 IL6 TNF
24 prosthetic joint infection 10.2 TLR2 TLR4
25 leukomalacia 10.2 IL6 TNF
26 granulomatous dermatitis 10.2 NOD2 TNF
27 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
28 critical limb ischemia 10.2 IL6 TNF
29 streptococcal toxic-shock syndrome 10.2 IL6 TNF
30 juvenile ankylosing spondylitis 10.2 IL6 TNF
31 cardiogenic shock 10.2 IL6 TNF
32 periodontitis, chronic 10.2 IL6 TLR2
33 null-cell leukemia 10.2 IL6 TNF
34 retinitis pigmentosa 55 10.2 IL6 TNF
35 rheumatoid lung disease 10.2 IL17A TNF
36 glossitis 10.2 IL6 TNF
37 laryngitis 10.2 IL6 TNF
38 fungal keratitis 10.2 TLR2 TLR4
39 neurosyphilis 10.2 IL17A TLR2
40 haemophilus influenzae 10.2 TLR2 TNF
41 posterior urethral valves 10.2 IL6 TNF
42 endometrial disease 10.2 IL6 TLR4 TNF
43 trench fever 10.2 TLR2 TLR4 TNF
44 congenital cytomegalovirus 10.2 TLR2 TNF
45 penicilliosis 10.2 TLR2 TLR4 TNF
46 osteosclerotic myeloma 10.2 IL6 TNF
47 uveitis 10.2 IL17A NOD2 TNF
48 idiopathic neutropenia 10.2 IL6 TLR4 TNF
49 pyelonephritis 10.2 IL6 TLR4 TNF
50 brucellosis 10.2 IL6 TLR4 TNF

Graphical network of the top 20 diseases related to Ileitis:



Diseases related to Ileitis

Symptoms & Phenotypes for Ileitis

Symptoms:

12
  • abdominal pain
  • weight loss
  • diarrhea

MGI Mouse Phenotypes related to Ileitis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.23 CCR3 CSF2 FABP2 IL17A IL6 MPO
2 hematopoietic system MP:0005397 10.22 CCR3 CSF2 IL17A IL6 MPO NOD2
3 growth/size/body region MP:0005378 10.19 CSF2 FABP2 IL17A IL6 NOD2 TLR2
4 immune system MP:0005387 10.17 CCR3 CSF2 IL17A IL6 MPO NOD2
5 cardiovascular system MP:0005385 10.14 CSF2 IL6 MPO TLR2 TLR4 TLR5
6 digestive/alimentary MP:0005381 10.13 IL17A IL6 NOD2 TLR2 TLR4 TLR5
7 adipose tissue MP:0005375 10.09 CSF2 FABP2 IL6 TLR2 TLR4 TLR5
8 mortality/aging MP:0010768 10.07 CSF2 IL17A IL6 MPO NOD2 TLR2
9 endocrine/exocrine gland MP:0005379 10.05 CSF2 IL17A IL6 TLR2 TLR5 TNF
10 liver/biliary system MP:0005370 9.95 FABP2 IL6 TLR2 TLR4 TLR5 TNF
11 muscle MP:0005369 9.8 IL6 MPO TLR2 TLR4 TNF XPNPEP1
12 neoplasm MP:0002006 9.73 CSF2 IL6 TLR2 TLR4 TNF XPNPEP1
13 renal/urinary system MP:0005367 9.7 CSF2 FABP2 IL17A IL6 TLR2 TLR4
14 respiratory system MP:0005388 9.61 CCR3 CSF2 IL17A IL6 TLR2 TLR4
15 skeleton MP:0005390 9.23 CSF2 IL17A IL6 NOD2 TLR2 TLR4

Drugs & Therapeutics for Ileitis

Drugs for Ileitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4 81103-11-9 84029
2
Rifabutin Approved, Investigational Phase 4 72559-06-9 6323490
3
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
4
Infliximab Approved Phase 4 170277-31-3
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6 Vedolizumab Approved Phase 4,Phase 2 943609-66-3
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Antitubercular Agents Phase 4,Phase 2
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
13 Cytochrome P-450 CYP3A Inhibitors Phase 4
14 Antirheumatic Agents Phase 4,Phase 3
15 Dermatologic Agents Phase 4
16 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
17 Topoisomerase Inhibitors Phase 4
18 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
19
Adalimumab Approved Phase 3 331731-18-1 16219006
20
Ursodeoxycholic acid Approved, Investigational Phase 3 128-13-2 31401
21
Alicaforsen Investigational Phase 3 185229-68-9 16197724
22 Antimetabolites, Antineoplastic Phase 3
23 Immunologic Factors Phase 3,Phase 1,Not Applicable
24 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
25 6-Mercaptopurine Phase 3
26 Immunosuppressive Agents Phase 3
27 Antimetabolites Phase 3
28 Cholagogues and Choleretics Phase 3
29 Bile Acids and Salts Phase 3
30
Rifaximin Approved, Investigational Phase 2 80621-81-4 6436173
31
Leuprolide Approved, Investigational Phase 2 53714-56-0 657181 3911
32
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
33 Antibodies, Monoclonal Phase 2,Phase 1
34 Antibodies Phase 2,Phase 1,Not Applicable
35 Immunoglobulins Phase 2,Phase 1,Not Applicable
36 Rifamycins Phase 2
37 rifamycin SV Phase 2
38 Complement System Proteins Phase 2
39 Androgen Antagonists Phase 2
40 Antineoplastic Agents, Hormonal Phase 2
41 Hormones Phase 2
42 Androgens Phase 2
43 Fertility Agents Phase 2
44
Azathioprine Approved 446-86-6 2265
45 Defensins
46 Acidophilus Not Applicable

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
2 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
3 Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis Recruiting NCT02790138 Phase 4 Vedolizumab;Ciprofloxacin;Vedolizumab Placebo
4 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
5 Efficacy of Alicaforsen in Pouchitis Patients Who Have Failed to Respond to at Least One Course of Antibiotics Completed NCT02525523 Phase 3 Alicaforsen;Placebo
6 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
7 Adalimumab in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3 Adalimumab;Placebo
8 the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis Recruiting NCT03524352 Phase 3
9 The Role of Secondary Bile Acids in Intestinal Inflammation Not yet recruiting NCT03724175 Phase 3 ursodiol (ursodeoxycholic acid, UDCA)
10 An Australian Study of Mesenchymal Stromal Cells for Crohn's Disease Completed NCT01090817 Phase 2 Mesenchymal stromal cells (MSC) for infusion
11 Efficacy, Safety and Pharmacokinetics of BI 655066/ABBV-066 (Risankizumab) in Patients With Active, Moderate-to-severe Crohn's Disease. Completed NCT02031276 Phase 2 risankizumab IV;risankizumab SC;Placebo
12 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Completed NCT02201186 Phase 2
13 Safety and Efficacy of AST-120 in the Treatment of Pouchitis Completed NCT00583076 Phase 2 AST-120
14 FMT in Ulcerative Colitis-Associated Pouchitis Completed NCT02049502 Phase 2
15 A Multicentre Study on Rifaximin in Post-operative Endoscopic Crohn's Disease Recurrence Prevention Recruiting NCT03537157 Phase 2 Rifaximin delayed release tablets
16 Vedolizumab Post Op Study Recruiting NCT02834754 Phase 2 Vedolizumab;placebo
17 Salvage Radiotherapy Combined With Hormonotherapy in Oligometastatic Pelvic Node Relapses of Prostate Cancer Active, not recruiting NCT02274779 Phase 2 ELIGARD
18 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Active, not recruiting NCT02782325 Phase 1, Phase 2
19 Fecal Microbiota Transplantation in the Treatment of Pouchitis Active, not recruiting NCT03378921 Phase 2
20 Fecal Microbiota Transplantation for Pouchitis Not yet recruiting NCT03545386 Phase 2
21 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
22 Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2 AST-120
23 Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs Completed NCT01387594 Phase 1 lumbar puncture
24 Study of Sc-FOS for Pouchitis Prevention Active, not recruiting NCT02203955 Phase 1 Short-Chain Fructooligosaccharide;Maltodextrin
25 The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis Unknown status NCT01202396
26 Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA Completed NCT02828410 Not Applicable
27 Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis Completed NCT01798953
28 Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis Recruiting NCT03256240 Not Applicable
29 Fecal Transplantation for Chronic Pouchitis - A Pilot Study Recruiting NCT03538366 Not Applicable
30 Microbiota and Immune microEnvironment in Pouchitis Recruiting NCT03136419 Not Applicable
31 Fecal Microbiota Transplant (FMT) for Pouchitis Active, not recruiting NCT02428361 Early Phase 1 Biologically active human fecal material, OpenBiome
32 Post-Operative Crohn's Disease Outcome in Children Not yet recruiting NCT03681652 Azathioprine;Anti-TNF Drug
33 IDENTIFICATION OF PROGNOSTIC AND PREDICTIVE BIOMARKERS IN INFLAMMATORY BOWEL DISEASE Not yet recruiting NCT03809728 Not Applicable
34 Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis Not yet recruiting NCT03526796 Not Applicable
35 Comparing the Quality of Life of Terminal Ileitis Patients With Crohn's Disease Treated With Anti-TNF or Surgical Resection Withdrawn NCT02872506 Not Applicable Anti TNF

Search NIH Clinical Center for Ileitis

Cochrane evidence based reviews: ileitis

Genetic Tests for Ileitis

Anatomical Context for Ileitis

MalaCards organs/tissues related to Ileitis:

41
Small Intestine, Colon, Liver, Monocytes, Lung, Skin, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Ileitis:

19
Ileum

Publications for Ileitis

Articles related to Ileitis:

(show top 50) (show all 715)
# Title Authors Year
1
Intestinal Perforation Due to Crohn's Ileitis Immunosuppression Related Lymphoma and Meckel's Diverticulum. ( 29730434 )
2018
2
Acute Terminal Ileitis in Children: A Retrospective Study in Pediatric Emergency Department. ( 29596286 )
2018
3
Endoscopic valvectomy of ileocecal valve stricture resulting in resolution of ileitis in Crohn's disease. ( 29476842 )
2018
4
Incidence and Long-Term Implications of Prepouch Ileitis: An Observational Study. ( 29369899 )
2018
5
Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. ( 29545800 )
2018
6
Isolated Terminal Ileitis: When Is It Not Crohn's Disease? ( 29536222 )
2018
7
Microscopic ileitis in diverted and nondiverted enteric segments: an underrecognized condition with a multifactorial etiology. ( 29596895 )
2018
8
Severe Cytomegalovirus ileitis preceded by acute bacterial enteritis in an immunocompetent patient. ( 29562388 )
2018
9
Severe inflammatory ileitis resulting in ileal perforation in association with combination immune checkpoint blockade for metastatic malignant melanoma. ( 29622719 )
2018
10
Histologic features in pediatric ileitis: Is it possible to tip the balance towards Crohn's disease? ( 29397324 )
2018
11
The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn's Disease-Like Ileitis. ( 29554272 )
2018
12
Effective use of ustekinumab for prepouch ileitis without improvement of concomitant pouchitis. ( 29423578 )
2018
13
How do you treat this diversion ileitis and pouchitis? ( 29588334 )
2018
14
Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis. ( 29545797 )
2018
15
Histological features of ileitis differentiating pediatric Crohn disease from ulcerative colitis with backwash ileitis. ( 29089273 )
2018
16
Case Report and Literature Review Illustrating the Clinical, Endoscopic, Radiologic, and Histopathologic Findings with Prepouch Ileitis after IPAA and Restorative Proctocolectomy for Refractory Ulcerative Colitis. ( 30155319 )
2018
17
Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn's Disease. ( 30295722 )
2018
18
Crohn's Disease-Like Ileitis and the Inhibitory Effect of Sucralose on Streptococci. ( 30099495 )
2018
19
Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis. ( 29997909 )
2018
20
Peroral Low-Dose Toxoplasma gondii Infection of Human Microbiota-Associated Mice - A Subacute Ileitis Model to Unravel Pathogen-Host Interactions. ( 29997912 )
2018
21
US Molecular Imaging of Acute Ileitis: Anti-Inflammatory Treatment Response Monitored with Targeted Microbubbles in a Preclinical Model. ( 30040040 )
2018
22
US Molecular Imaging Sensitively Captures Acute Ileitis Therapy Response. ( 30040043 )
2018
23
Unusual etiology for sub-acute terminal ileitis in a 5 year old. ( 30240667 )
2018
24
Idiopathic ischaemic ileitis, with overt obscure digestive bleeding. ( 30455040 )
2018
25
Capecitabine-Associated Terminal Ileitis. ( 30483093 )
2018
26
Diagnostic Value of Small Bowel Capsule Endoscopy in Isolated Ileitis: A Methodological Mistake. ( 28255834 )
2017
27
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis. ( 28108786 )
2017
28
Epicutaneous Tolerance Induction to a Bystander Antigen Abrogates Colitis and Ileitis in Mice. ( 29019858 )
2017
29
Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis. ( 28146004 )
2017
30
Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn's disease-like ileitis. ( 28165466 )
2017
31
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial. ( 28838644 )
2017
32
Foreign body ileitis: a histopathological mimic of Crohn's disease? ( 28689632 )
2017
33
Intestinal, extra-intestinal and systemic sequelae of Toxoplasma gondii induced acute ileitis in mice harboring a human gut microbiota. ( 28414794 )
2017
34
Backwash Is Hogwash: The Clinical Significance of Ileitis in Ulcerative Colitis. ( 28631729 )
2017
35
Prepouch Ileitis After Ileal Pouch-anal Anastomosis: Patterns of Presentation and Risk Factors for Failure of Treatment. ( 29240877 )
2017
36
The Ileitis of Ulcerative Colitis. Why Is It Not Crohn's Disease? ( 28079623 )
2017
37
Yersinia Enterocolitica Ileitis Mimicking Pediatric Crohn's Disease. ( 28230560 )
2017
38
Aspecific ileitis: Crohn's disease or not Crohn's disease? A prospective study. ( 28161731 )
2017
39
Isolated Acute Terminal Ileitis Without Preexisting Inflammatory Bowel Disease Rarely Progresses to Crohn's Disease. ( 29064015 )
2017
40
An unexpected cause of terminal ileitis. ( 27729214 )
2017
41
A rare case of Crohn's ileitis in a patient with constitutional mismatch repair deficiency. ( 28469372 )
2017
42
Chronic ileitis with transmural migration of ingested foreign body treated by laparoscopy. ( 28920530 )
2017
43
A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. ( 28301579 )
2017
44
Fistulating Crohn's terminal ileitis involving sigmoid colon, left salpinx and urinary bladder: a laparoscopic approach - a video vignette. ( 28603931 )
2017
45
Defective ATG16L1-mediated removal of IRE1I+ drives Crohn's disease-like ileitis. ( 28082357 )
2017
46
Post-inflammatory Ileitis Induces Non-neuronal Purinergic Signaling Adjustments of Cholinergic Neurotransmission in the Myenteric Plexus. ( 29167643 )
2017
47
Diagnostic Value of Small Bowel Capsule Endoscopy in Isolated Ileitis: A CAPENTRY Study. ( 27889847 )
2017
48
An Unusual Cause of Granulomatous Ileitis - With a Brief History of the Pathology of Typhoid. ( 29034754 )
2017
49
Acute ileitis facilitates infection with multidrug resistant Pseudomonas aeruginosa in human microbiota-associated mice. ( 28115993 )
2017
50
Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model? ( 28560286 )
2017

Variations for Ileitis

Expression for Ileitis

Search GEO for disease gene expression data for Ileitis.

Pathways for Ileitis

Pathways related to Ileitis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CSF2 IL17A IL6 MPO NOD2 TLR2
2
Show member pathways
13.31 CCR3 CSF2 IL17A IL6 TLR2 TLR4
3
Show member pathways
12.98 CCR3 CSF2 IL6 TLR2 TLR4 TNF
4
Show member pathways
12.93 IL6 NOD2 TLR2 TLR4 TLR5 TNF
5
Show member pathways
12.7 IL6 TLR2 TLR4 TNF
6
Show member pathways
12.64 IL6 TLR2 TLR4 TLR5 TNF
7
Show member pathways
12.53 TLR2 TLR4 TLR5 TNF
8
Show member pathways
12.51 IL17A IL6 MPO TNF
9 12.49 IL17A MPO TLR2 TNF
10
Show member pathways
12.36 CSF2 IL17A IL6 TNF
11
Show member pathways
12.34 IL17A IL6 NOD2 TLR2 TLR4 TLR5
12
Show member pathways
12.21 IL6 TLR2 TLR4 TLR5 TNF
13
Show member pathways
12.17 IL6 TLR2 TLR5 TNF
14 12.16 IL6 NOD2 TLR2 TLR4 TNF
15
Show member pathways
12.13 CSF2 IL17A IL6 TLR2 TLR5 TNF
16
Show member pathways
12.11 IL6 TLR2 TLR4 TLR5 TNF
17 12.09 IL6 TLR2 TLR4 TLR5 TNF
18 12.06 MPO TLR2 TLR4
19
Show member pathways
11.96 TLR2 TLR4 TLR5
20 11.94 IL6 TLR4 TNF
21 11.93 CSF2 IL6 NOD2 TNF
22
Show member pathways
11.93 CSF2 IL6 TLR2 TLR4 TNF
23 11.91 IL17A IL6 TNF
24 11.87 CCR3 CSF2 IL6 MPO TNF
25
Show member pathways
11.85 CSF2 IL17A IL6 TLR4
26 11.83 CSF2 IL6 TNF
27 11.8 CSF2 IL6 TLR4 TLR5
28 11.77 TLR2 TLR4 TLR5
29 11.75 CSF2 IL6 TLR2 TLR4 TNF
30 11.72 IL6 TLR4 TNF
31 11.7 CSF2 IL6 TNF
32 11.7 CSF2 IL17A IL6 TNF
33
Show member pathways
11.63 CSF2 IL6 TNF
34 11.62 CCR3 CSF2 IL6 TNF
35
Show member pathways
11.55 IL17A IL6 TLR2 TLR4 TLR5 TNF
36 11.51 CSF2 IL6 TNF
37 11.49 IL6 MPO TNF
38 11.49 TLR2 TLR4 TNF
39 11.45 IL6 TLR2 TLR4 TNF
40 11.33 IL6 TLR4 TNF
41 11.29 IL6 TLR2 TLR4 TLR5 TNF
42 11.28 IL17A IL6 TNF
43 11.23 CSF2 IL6 TNF
44 11.17 CSF2 IL17A IL6 TNF
45 11.1 CCR3 TLR2
46 11.06 NOD2 TNF
47 11.05 CSF2 IL17A IL6 TLR2 TLR4 TNF
48 11.04 IL6 TNF
49 10.97 IL6 TNF
50 10.89 MPO TNF

GO Terms for Ileitis

Cellular components related to Ileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CCR3 IL17A TLR4 TNF

Biological processes related to Ileitis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CSF2 IL17A IL6 TNF
2 positive regulation of gene expression GO:0010628 9.98 CSF2 IL6 TLR2 TLR4 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.94 CSF2 IL17A IL6 TNF
4 defense response to bacterium GO:0042742 9.91 MPO NOD2 TLR4 TLR5 TNF
5 immune response GO:0006955 9.91 CCR3 CSF2 IL17A IL6 TLR2 TLR4
6 response to lipopolysaccharide GO:0032496 9.87 MPO TLR2 TLR4
7 defense response GO:0006952 9.86 MPO NOD2 TNF
8 activation of MAPK activity GO:0000187 9.85 NOD2 TLR4 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.83 IL6 TLR2 TNF
10 positive regulation of JNK cascade GO:0046330 9.81 NOD2 TLR4 TNF
11 positive regulation of inflammatory response GO:0050729 9.8 TLR2 TLR4 TNF
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL6 NOD2 TLR2 TLR4 TNF
13 inflammatory response GO:0006954 9.8 CCR3 IL17A IL6 TLR2 TLR4 TLR5
14 regulation of inflammatory response GO:0050727 9.79 NOD2 TLR4 TNF
15 positive regulation of tumor necrosis factor production GO:0032760 9.77 NOD2 TLR2 TLR4
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 TLR4 TLR5 TNF
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 TLR2 TLR4 TNF
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.73 NOD2 TLR2 TLR4 TNF
19 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.72 TLR2 TLR4 TLR5
20 negative regulation of neurogenesis GO:0050768 9.7 IL6 TNF
21 positive regulation of interleukin-10 production GO:0032733 9.7 NOD2 TLR2 TLR4
22 positive regulation of interleukin-12 production GO:0032735 9.69 TLR2 TLR4
23 positive regulation of osteoclast differentiation GO:0045672 9.69 IL17A TNF
24 positive regulation of stress-activated MAPK cascade GO:0032874 9.68 NOD2 TLR4
25 microglial cell activation GO:0001774 9.68 TLR2 TNF
26 positive regulation of glial cell proliferation GO:0060252 9.68 IL6 TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.67 MPO TNF
28 I-kappaB phosphorylation GO:0007252 9.67 TLR2 TLR4
29 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.67 IL17A NOD2 TLR4
30 positive regulation of podosome assembly GO:0071803 9.66 CSF2 TNF
31 macrophage activation GO:0042116 9.65 CSF2 TLR4
32 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 TLR4
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.65 TLR4 TNF
34 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 NOD2 TLR2 TLR4
35 negative regulation of lipid storage GO:0010888 9.63 IL6 TNF
36 regulation of cytokine secretion GO:0050707 9.63 TLR2 TLR4 TLR5
37 cellular response to lipopolysaccharide GO:0071222 9.63 CSF2 IL6 NOD2 TLR4 TLR5 TNF
38 positive regulation of chemokine production GO:0032722 9.62 IL6 TLR2 TLR4 TNF
39 positive regulation of neuroinflammatory response GO:0150078 9.61 IL6 TNF
40 positive regulation of interleukin-23 production GO:0032747 9.61 CSF2 IL17A
41 positive regulation of toll-like receptor signaling pathway GO:0034123 9.59 TLR2 TLR5
42 cytokine secretion involved in immune response GO:0002374 9.57 NOD2 TLR2
43 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.54 TLR2 TLR4
44 positive regulation of interleukin-6 production GO:0032755 9.35 IL6 NOD2 TLR2 TLR4 TNF
45 positive regulation of interleukin-8 production GO:0032757 9.02 NOD2 TLR2 TLR4 TLR5 TNF
46 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 IL17A IL6 NOD2 TLR2 TLR4 TNF

Molecular functions related to Ileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CSF2 IL17A IL6 TNF
2 peptidoglycan binding GO:0042834 9.16 NOD2 TLR2
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Ileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....