Aliases & Classifications for Ileitis

MalaCards integrated aliases for Ileitis:

Name: Ileitis 12 54 43 15 71
Crohn's Ileitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060189
MeSH 43 D007079
NCIt 49 C84782
SNOMED-CT 67 52457000
ICD10 32 K52.9
UMLS 71 C0020877

Summaries for Ileitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in ileum, has symptom diarrhea, has symptom abdominal pain, often in the right lower quadrant, has symptom weight loss.

MalaCards based summary : Ileitis, also known as crohn's ileitis, is related to crohn's disease and pouchitis, and has symptoms including weight loss, abdominal pain and diarrhea. An important gene associated with Ileitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clarithromycin and Clofazimine have been mentioned in the context of this disorder. Affiliated tissues include ileum, small intestine and colon, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Ileitis is an inflammation of the ileum, a portion of the small intestine. Crohn's ileitis is a type of... more...

Related Diseases for Ileitis

Diseases related to Ileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 559)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 32.3 TNF TLR5 TLR4 TLR2 NOD2 MADCAM1
2 pouchitis 31.6 TLR4 NOD2
3 crohn's colitis 31.3 TNF NOD2 CCR6
4 diarrhea 31.1 TNF TLR4 NOD2 MPO IL6
5 intestinal obstruction 31.1 TNF NOD2 IL6
6 appendicitis 31.0 TNF TLR4 MPO IL6 IL17A
7 lymphadenitis 30.9 TNF TLR4 NOD2 CCR6
8 ileus 30.9 TNF IL6 IL17A CSF2
9 spondylarthropathy 30.8 TNF TLR4 TLR2 NOD2
10 vasculitis 30.8 TNF MPO IL6 IL17A
11 cytomegalovirus infection 30.7 TNF IL6 CCL5
12 diverticulitis 30.7 TNF IL6 CCR6
13 cystitis 30.7 TNF TLR4 IL6 IL17A
14 brucellosis 30.7 TNF TLR4 MPO IL6 IL17A
15 hypereosinophilic syndrome 30.6 MPO CSF2 CCR3 CCL5
16 intestinal perforation 30.6 TNF TLR4 NOD2 IL6 FABP2
17 pulmonary tuberculosis 30.6 TNF TLR4 TLR2 IL6
18 ulcerative colitis 30.5 TNF TLR5 TLR4 NOD2 MPO IL6
19 sarcoidosis 1 30.4 TNF NOD2 CCR6 CCR5 CCL5
20 peritonitis 30.4 TNF TLR4 TLR2 MPO IL6 IL17A
21 spondylitis 30.4 TNF NOD2 IL6 IL17A CCR6
22 gastritis 30.4 TNF TLR4 IL6 IL17A CCR6 CCL5
23 typhoid fever 30.4 TNF TLR5 TLR4 IL6 CCR6
24 plague 30.4 TNF TLR5 TLR4 TLR2 IL6 CCR5
25 intestinal disease 30.3 TNF TLR4 NOD2 IL6 IL17A CCR6
26 familial mediterranean fever 30.3 TNF TLR4 TLR2 NOD2 IL6 IL17A
27 pyoderma 30.3 TNF NOD2 CCR6
28 pyoderma gangrenosum 30.3 TNF NOD2 CCR6
29 spondyloarthropathy 1 30.3 TNF TLR4 NOD2 IL17A CCR6
30 autoimmune gastritis 30.3 TNF IL6 CCR6
31 esophagitis 30.2 TNF IL6 CCL5
32 contact dermatitis 30.2 TNF TLR4 TLR2 IL6 IL17A
33 spondyloarthropathy 30.2 TNF IL6 IL17A CCR6
34 uveitis 30.2 TNF NOD2 IL6 IL17A CCR5
35 sclerosing cholangitis 30.1 TNF TLR4 NOD2 MPO MADCAM1 IL6
36 kaposi sarcoma 30.1 IL6 CSF2 CCR8 CCR5 CCR3
37 allergic hypersensitivity disease 30.1 TNF IL17A CSF2 CCR6 CCR3 CCL5
38 herpes zoster 30.1 TNF TLR2 CCR6 CCR5
39 mycobacterium tuberculosis 1 30.1 TNF TLR4 TLR2 NOD2 IL17A CCR6
40 herpes simplex 30.0 TNF TLR2 IL6 CCL5
41 dysentery 30.0 TNF TLR4 TLR2 IL6 CCR6
42 chlamydia 30.0 TNF TLR4 TLR2 IL6 IL17A CSF2
43 neutropenia 30.0 TNF TLR4 MPO IL6 CSF2
44 exanthem 30.0 TNF MPO IL6 CSF2 CCR6
45 proteasome-associated autoinflammatory syndrome 1 30.0 TNF TLR5 TLR4 TLR2 MPO IL6
46 colitis 30.0 TNF TLR5 TLR4 TLR2 NOD2 MPO
47 cholangitis 30.0 TNF TLR4 NOD2 MPO MADCAM1 IL6
48 peripheral nervous system disease 29.8 TNF TLR4 TLR2 IL6 IL17A CCR6
49 acquired immunodeficiency syndrome 29.8 TNF MADCAM1 IL6 CSF2 CCR6 CCR5
50 thrombocytopenia 29.8 TNF TLR5 TLR4 TLR2 IL6 IL17A

Graphical network of the top 20 diseases related to Ileitis:



Diseases related to Ileitis

Symptoms & Phenotypes for Ileitis

Symptoms:

12
  • weight loss
  • abdominal pain
  • diarrhea

MGI Mouse Phenotypes related to Ileitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.27 CCL25 CCL5 CCR3 CCR5 CCR6 CCR9
2 immune system MP:0005387 10.19 CCL25 CCL5 CCR3 CCR5 CCR6 CCR8
3 homeostasis/metabolism MP:0005376 10.17 CCR3 CCR5 CCR6 CSF2 FABP2 IL17A
4 digestive/alimentary MP:0005381 10.14 CCL25 CCR5 CCR9 IL17A IL6 NOD2
5 adipose tissue MP:0005375 10.09 CCL25 CSF2 FABP2 IL6 RETNLB TLR2
6 liver/biliary system MP:0005370 9.76 CCR5 FABP2 IL6 RETNLB TLR2 TLR4
7 neoplasm MP:0002006 9.5 CCR5 CSF2 IL6 RETNLB TLR2 TLR4
8 respiratory system MP:0005388 9.23 CCR3 CSF2 IL17A IL6 TLR2 TLR4

Drugs & Therapeutics for Ileitis

Drugs for Ileitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4 81103-11-9 84029
2
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
3
Rifabutin Approved, Investigational Phase 4 72559-06-9 6323490 46783538
4 Anti-Inflammatory Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Cytochrome P-450 Enzyme Inhibitors Phase 4
7 Cytochrome P-450 CYP3A Inhibitors Phase 4
8 Anti-Bacterial Agents Phase 4
9 Antitubercular Agents Phase 4
10 Antibiotics, Antitubercular Phase 4
11
Adalimumab Approved Phase 3 331731-18-1 16219006
12
Mercaptopurine Approved Phase 3 50-44-2 667490
13 Immunologic Factors Phase 3
14 Immunosuppressive Agents Phase 3
15 Antirheumatic Agents Phase 3
16 Antimetabolites Phase 3
17
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
18
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
19 Hormones Phase 1, Phase 2
20 Hormone Antagonists Phase 1, Phase 2
21 Anti-Infective Agents, Local Phase 1, Phase 2
22 Antifungal Agents Phase 1, Phase 2
23 Immunoglobulins Phase 1
24 Antibodies Phase 1
25 Antibodies, Monoclonal Phase 1
26
Infliximab Approved 170277-31-3
27
Glucosamine Approved, Investigational 3416-24-8 439213

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
2 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
3 An Investigator Initiated Prospective, Single Center, Randomized, Open Label Study to Assess the Efficacy of Adalimumab for the Maintenance of Remission in Post-operative CD Patients Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
4 Diagnosis of Intraepithelial Neoplasia in Patients With Long Standing Ulcerative Colitis With Chromoscopic Guided Endomicroscopy Completed NCT00352404 Phase 3
5 A Multicentre Australian Phase 2 Study to Evaluate Safety and Efficacy of Mesenchymal Stromal Cells for Treating Biologic Refractory Crohn's Disease Completed NCT01090817 Phase 2 Mesenchymal stromal cells (MSC) for infusion
6 A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study to Evaluate Efficacy and Safety of Oral BT-11 in Moderate to Severe Crohn's Disease Not yet recruiting NCT03870334 Phase 2 BT-11 1,000 mg;Placebo
7 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
8 A Multi-Center, Phase 1, Open-Label Evaluation Of The Effect Of PF-00547659 (Anti Madcam Monoclonal Antibody) On Cerebrospinal Fluid (CSF) Lymphocytes In Volunteers With Crohns Disease Or Ulcerative Colitis Who Are Anti-TNFInadequate Responders (TOSCA) Completed NCT01387594 Phase 1 lumbar puncture
9 Mucosal Gene Expression Defects in Patients With Inflammatory Bowel Disease Before and After First Infliximab Therapy Completed NCT00639821
10 Predictors of Tissue Healing in Inflammatory Bowel Disease Patients Treated With Anti-TNF Completed NCT01605175
11 Predictors of Non-response and Loss of Response in IBD Patients Treated With Anti-TNF. Completed NCT01605188
12 Prospective Randomized Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis in the Prevention of Post-operative Recurrence of Crohn's Disease Recruiting NCT03256240
13 A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Crohn's Disease Recruiting NCT04100005
14 Combined PET-MRI in the Diagnostics of Chronic Inflammatory Bowel Diseases (IBD)- a Feasibility Study Recruiting NCT02364973
15 99mTc-labelled D-Glucosamine in the Evaluation of Disease Activity in Patients With Degenerative and Inflammatory Rheumatic Conditions No longer available NCT01789151
16 Phase III Study Comparing 3D Conformal Radiotherapy and Conformal Radiotherapy IMRT to Treat Endometrial Cancer of 70 Years Old Women : Contribution of Oncogeriatric Evaluation to the Study of Acute Toxicity Terminated NCT01641497
17 Comparing the Quality of Life of Terminal Ileitis Patients With Crohn's Disease Treated With Anti-TNF or Surgical Resection Withdrawn NCT02872506 Anti TNF

Search NIH Clinical Center for Ileitis

Cochrane evidence based reviews: ileitis

Genetic Tests for Ileitis

Anatomical Context for Ileitis

The Foundational Model of Anatomy Ontology organs/tissues related to Ileitis:

19
Ileum

MalaCards organs/tissues related to Ileitis:

40
Small Intestine, Colon, T Cells, Liver, Testes, Neutrophil, Bone

Publications for Ileitis

Articles related to Ileitis:

(show top 50) (show all 2116)
# Title Authors PMID Year
1
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease. 61 54
19079235 2008
2
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. 61 54
16682432 2006
3
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease. 61 54
16401463 2006
4
Carriage of CARD15 variants and smoking as risk factors for resective surgery in patients with Crohn's ileal disease. 61 54
16167972 2005
5
L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. 54 61
15699171 2005
6
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. 61 54
14570728 2003
7
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. 61 54
12706472 2003
8
Anti-inflammatory agents and substance P depletion in experimental ileitis. 61 54
18475536 1993
9
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice. 61
32345659 2020
10
Hepatocyte nuclear factor-4α regulates expression of the serotonin transporter in intestinal epithelial cells. 61
32348179 2020
11
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. 61
32362323 2020
12
Primary Sclerosing Cholangitis in Children With Inflammatory Bowel Diseases Is Associated With Milder Clinical Activity But More Frequent Subclinical Inflammation and Growth Impairment. 61
31493578 2020
13
Immunoglobulin A vasculitis presenting as terminal ileitis in late adulthood. 61
32568288 2020
14
A plethora of manifestations following a Mycoplasma pneumoniae infection: a case report. 61
30767713 2020
15
FDG-PET-CT Enterography Helps Determine Clinical Significance of Suspected Ileocecal Thickening: A Prospective Study. 61
32488818 2020
16
Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network. 61
31136648 2020
17
Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease. 61
32448900 2020
18
Gut stem cell necroptosis by genome instability triggers bowel inflammation. 61
32296174 2020
19
Meckel Diverticulum Presenting as Abdominal Pain and Subsequent Bowel Perforation. 61
32317193 2020
20
Not All Terminal Ileitis Is Crohn's Disease: Intestinal Tuberculosis Causing Small Bowel Obstruction. 61
32360806 2020
21
[Terminal ileitis due to Yersinia enterocolitica: differential diagnosis with Crohn´s disease in a 12-year-old male]. 61
32199063 2020
22
Burkitt lymphoma masquerading as Tolosa-Hunt syndrome in an HIV-seropositive patient. 61
31018683 2020
23
Adult-Onset Immunoglobulin A Vasculitis. 61
32337300 2020
24
Can microscopic ileitis in patients with clinically suspected inflammatory bowel disease predict the future? 61
32138683 2020
25
Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice. 61
32072024 2020
26
Short- and long-term outcomes following side-to-side strictureplasty and its modification over the ileocecal valve for extensive Crohn's ileitis. 61
32227163 2020
27
Comparative Analysis of Antigiardial Potential of Heat Inactivated and Probiotic Protein of Probiotic Lactobacillus rhamnosus GG in Murine Giardiasis. 61
30610454 2020
28
Human Gut Microbiome Transplantation in Ileitis Prone Mice: A Tool for the Functional Characterization of the Microbiota in Inflammatory Bowel Disease Patients. 61
31750921 2020
29
Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence. 61
32111634 2020
30
Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis. 61
32111635 2020
31
Fatal intestinal inflammatory lesions in equids in California: 710 cases (1990-2013). 61
31999521 2020
32
Severe terminal ileitis induced by single-agent nivolumab administered every four weeks. 61
32028838 2020
33
Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography. 61
31433363 2020
34
[Ileitis as presentation of lymphoma in Wiskott-Aldrich syndrome]. 61
32044744 2020
35
Terminal Ileitis due to Yersinia Infection: An Underdiagnosed Situation. 61
32566652 2020
36
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn's Disease-Like Inflammation. 61
31276162 2020
37
Michelassi II Strictureplasty for Crohn's Disease: A New Side-to-Side Isoperistaltic Strictureplasty With Discontinuous Bowel Loops. 61
31860550 2020
38
Characteristics and Epidemiological Investigation of Paratuberculosis in Dairy Cattle in Tai'an, China. 61
32258119 2020
39
Dietary emulsifier polysorbate-80-induced small-intestinal vulnerability to indomethacin-induced lesions via dysbiosis. 61
31359491 2020
40
A secondary bile acid from microbiota metabolism attenuates ileitis and bile acid reduction in subclinical necrotic enteritis in chickens. 61
32190299 2020
41
Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn's-Like Ileitis by Suppressing Thymocyte Maturation. 61
31807751 2020
42
Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases? 61
31009791 2019
43
Neutralization of IL-1α ameliorates Crohn's disease-like ileitis by functional alterations of the gut microbiome. 61
31843928 2019
44
Histologic Healing Is More Strongly Associated with Clinical Outcomes in Ileal Crohn's Disease than Endoscopic Healing. 61
31812654 2019
45
Serum Concentrations of 7α-hydroxy-4-cholesten-3-one Are Associated With Bile Acid Diarrhea in Patients With Crohn's Disease. 61
30448597 2019
46
Small bowel perforation secondary to CMV-positive terminal ileitis postrenal transplant. 61
31772132 2019
47
Is Crohn's disease a rightly used eponym? 61
31701137 2019
48
Diffusion-weighted imaging and apparent diffusion coefficient values for evaluating terminal ileitis in patients with Crohn's disease. 61
32047329 2019
49
Intestinal Perforation Due to Crohn's Ileitis Immunosuppression Related Lymphoma and Meckel's Diverticulum. 61
29730434 2019
50
Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn's disease: the LIR!C Trial. 61
31233395 2019

Variations for Ileitis

Expression for Ileitis

Search GEO for disease gene expression data for Ileitis.

Pathways for Ileitis

Pathways related to Ileitis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNF TLR5 TLR4 TLR2 NOD2 MPO
2
Show member pathways
13.84 TNF IL6 IL17A CSF2 CCR9 CCR8
3
Show member pathways
13.66 TNF TLR4 IL6 IL17A CSF2 CCR9
4
Show member pathways
13.35 TNF NOD2 IL6 IL17A CSF2 CCR5
5
Show member pathways
13.06 TNF IL6 IL17A CSF2 CCR9 CCR8
6
Show member pathways
13.05 TNF TLR5 TLR4 TLR2 IL6 CCL5
7
Show member pathways
12.95 TNF TLR5 TLR4 TLR2 IL6 IL17A
8
Show member pathways
12.9 CCR9 CCR8 CCR6 CCR5 CCR3 CCL5
9
Show member pathways
12.87 TNF MADCAM1 IL6 IL17A CCR9 CCL25
10
Show member pathways
12.82 TNF TLR4 TLR2 IL6 CSF2 CCR8
11
Show member pathways
12.81 TNF TLR4 TLR2 IL6 CCL5
12
Show member pathways
12.75 TNF TLR5 TLR4 TLR2 NOD2 IL6
13
Show member pathways
12.7 TNF TLR5 TLR4 TLR2 IL6
14
Show member pathways
12.6 TNF TLR4 TLR2 IL6 IL17A CSF2
15 12.58 TNF TLR2 MPO IL17A CCL5
16
Show member pathways
12.58 TNF TLR5 TLR4 TLR2 NOD2 IL6
17 12.43 TNF TLR5 TLR4 CSF2 CCL5
18
Show member pathways
12.36 TNF TLR5 TLR2 IL6 IL17A CSF2
19 12.34 TNF TLR5 TLR4 TLR2 IL6
20
Show member pathways
12.33 TNF MPO IL6 CCL5
21
Show member pathways
12.3 TNF TLR5 TLR4 TLR2 IL6
22 12.27 TNF TLR5 TLR4 IL6
23 12.27 TNF TLR4 TLR2 NOD2 IL6
24
Show member pathways
12.26 TNF TLR4 TLR2 CCR5
25 12.23 TNF TLR5 TLR4 TLR2 IL6
26
Show member pathways
12.22 TNF TLR5 TLR4 TLR2 IL6
27 12.21 TNF TLR4 NOD2 IL6 DEFB103A CCL5
28 12.04 TNF MPO IL6 CSF2 CCR3
29 12.01 TNF NOD2 IL6 CSF2 CCL5
30 11.96 TNF TLR4 TLR2 IL6 CSF2
31
Show member pathways
11.91 TLR4 IL6 IL17A CSF2
32
Show member pathways
11.88 TLR5 TLR4 TLR2 IL6 IL17A
33
Show member pathways
11.82 TNF TLR5 TLR4 TLR2 IL6 IL17A
34 11.81 TLR5 TLR4 TLR2
35 11.78 TNF IL17A CCR6
36 11.75 TNF TLR4 IL6
37 11.74 TNF IL6 CSF2
38 11.67 TNF TLR4 TLR2 IL6 IL17A CSF2
39
Show member pathways
11.66 TNF IL6 CSF2
40 11.65 TNF IL6 CSF2 CCR3 CCL5
41
Show member pathways
11.61 TNF IL6 CCR9 CCR8 CCR6 CCR5
42 11.59 TNF TLR4 TLR2 IL6
43 11.59 TNF TLR5 TLR4 TLR2 IL6
44 11.53 TNF TLR4 TLR2
45 11.53 TNF MPO IL6
46 11.49 TNF IL6 CSF2 CCR5 CCL5
47 11.38 TNF TLR4 IL6
48 11.34 TNF IL6 IL17A
49 11.29 TNF IL6 CSF2
50 11.05 TNF IL6 IL17A CSF2 CCL5 CCL25

GO Terms for Ileitis

Cellular components related to Ileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TNF RETNLB MPO IL6 IL17A DEFB103A
2 extracellular space GO:0005615 9.97 TNF RETNLB MPO IL6 IL17A DEFB103A
3 cell GO:0005623 9.86 MPO IL6 CCR9 CCR8 CCR6 CCR5
4 integral component of plasma membrane GO:0005887 9.81 TNF TLR5 TLR4 TLR2 CCR9 CCR8
5 cell surface GO:0009986 9.5 TNF TLR4 TLR2 NOD2 CCR9 CCR6
6 external side of plasma membrane GO:0009897 9.23 TNF TLR4 IL17A CCR9 CCR8 CCR6

Biological processes related to Ileitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 TLR5 TLR4 TLR2 RETNLB MADCAM1 IL6
2 G protein-coupled receptor signaling pathway GO:0007186 10.24 CCR9 CCR8 CCR6 CCR5 CCR3 CCL5
3 positive regulation of gene expression GO:0010628 10.11 TNF TLR4 TLR2 IL6 CSF2
4 cytokine-mediated signaling pathway GO:0019221 10.04 TNF IL6 IL17A CSF2 CCR5 CCL5
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.03 TNF TLR4 NOD2 CCL5 CCL25
6 defense response to bacterium GO:0042742 10.03 TNF TLR5 TLR4 NOD2 MPO DEFB103A
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 TNF TLR4 TLR2 NOD2 IL6
8 defense response GO:0006952 9.99 TNF NOD2 MPO DEFB103A CCR5
9 positive regulation of cytosolic calcium ion concentration GO:0007204 9.98 CCR9 CCR8 CCR6 CCR5 CCR3
10 cellular response to lipopolysaccharide GO:0071222 9.98 TNF TLR5 TLR4 NOD2 IL6 CSF2
11 defense response to Gram-positive bacterium GO:0050830 9.96 TNF TLR2 IL6 DEFB103A
12 inflammatory response GO:0006954 9.96 TNF TLR5 TLR4 TLR2 IL6 IL17A
13 cellular response to interferon-gamma GO:0071346 9.94 TLR4 TLR2 CCL5 CCL25
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 CSF2 CCL5
15 chemotaxis GO:0006935 9.92 DEFB103A CCR9 CCR8 CCR6 CCR5 CCR3
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF TLR4 TLR2 NOD2
17 calcium-mediated signaling GO:0019722 9.91 CCR9 CCR8 CCR6 CCR5 CCR3
18 cellular response to interleukin-1 GO:0071347 9.89 IL17A CCL5 CCL25
19 positive regulation of JNK cascade GO:0046330 9.89 TNF TLR4 NOD2
20 cellular defense response GO:0006968 9.88 CCR9 CCR6 CCR5 CCR3
21 cellular response to organic cyclic compound GO:0071407 9.87 TNF NOD2 CCL5
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 TNF IL6 CCL5
23 humoral immune response GO:0006959 9.86 TNF IL6 CCR6
24 positive regulation of tumor necrosis factor production GO:0032760 9.86 TLR4 TLR2 NOD2
25 monocyte chemotaxis GO:0002548 9.85 IL6 CCL5 CCL25
26 toll-like receptor signaling pathway GO:0002224 9.85 TLR5 TLR4 TLR2
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 TNF TLR5 TLR4
28 positive regulation of interleukin-6 secretion GO:2000778 9.85 TNF TLR4 TLR2 IL17A
29 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR4 TLR2 NOD2 IL6
30 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.84 TLR5 TLR4 TLR2
31 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 TNF TLR4 TLR2 CCL5
32 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 CCL5
33 positive regulation of interleukin-10 production GO:0032733 9.82 TLR4 TLR2 NOD2
34 positive regulation of interleukin-8 secretion GO:2000484 9.8 TNF TLR4 TLR2
35 dendritic cell chemotaxis GO:0002407 9.8 CCR6 CCR5 CCL5
36 positive regulation of interleukin-8 production GO:0032757 9.8 TNF TLR5 TLR4 TLR2 NOD2
37 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.79 TLR4 TLR2 NOD2
38 positive regulation of chemokine production GO:0032722 9.78 TNF TLR4 TLR2 IL6
39 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.77 TNF TLR4 NOD2 IL6 IL17A
40 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.72 TNF TLR4
41 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL6
42 positive regulation of podosome assembly GO:0071803 9.72 TNF CSF2
43 regulation of cytokine secretion GO:0050707 9.72 TLR5 TLR2
44 I-kappaB phosphorylation GO:0007252 9.71 TLR4 TLR2
45 cellular response to lipoteichoic acid GO:0071223 9.71 TLR4 TLR2
46 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
47 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.7 TNF IL17A
48 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.7 TLR4 IL17A
49 negative regulation of macrophage apoptotic process GO:2000110 9.7 NOD2 CCR5 CCL5
50 chemokine-mediated signaling pathway GO:0070098 9.7 CCR9 CCR8 CCR6 CCR5 CCR3 CCL5

Molecular functions related to Ileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.8 TNF IL6 IL17A CSF2 CCL5 CCL25
2 signaling receptor activity GO:0038023 9.73 TLR5 TLR4 TLR2 CCR6
3 chemokine binding GO:0019956 9.65 CCR9 CCR8 CCR6 CCR5 CCR3
4 C-C chemokine binding GO:0019957 9.55 CCR9 CCR8 CCR6 CCR5 CCR3
5 chemokine receptor binding GO:0042379 9.4 CCL5 CCL25
6 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
7 C-C chemokine receptor activity GO:0016493 9.35 CCR9 CCR8 CCR6 CCR5 CCR3
8 chemokine receptor activity GO:0004950 9.02 CCR9 CCR8 CCR6 CCR5 CCR3

Sources for Ileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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