MCID: ILC002
MIFTS: 42

Ileocolitis

Categories: Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Ileocolitis

MalaCards integrated aliases for Ileocolitis:

Name: Ileocolitis 12 15
Iieocolitis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060190
ICD10 33 K52.9
UMLS 73 C0949272

Summaries for Ileocolitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon and located in ileum, has symptom diarrhea, has symptom weight loss, has symptom abdominal pain in middle or lower right part.

MalaCards based summary : Ileocolitis, also known as iieocolitis, is related to crohn's colitis and crohn's disease, and has symptoms including weight loss, diarrhea and abdominal pain in middle or lower right part. An important gene associated with Ileocolitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Th17 cell differentiation and NF-kappaB Signaling. The drugs Azathioprine and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Crohn''s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

Related Diseases for Ileocolitis

Diseases related to Ileocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 crohn's colitis 30.5 NOD2 TNF
2 crohn's disease 30.4 DLG5 NOD2 TNF
3 ileitis 30.3 NOD2 TNF
4 colitis 30.2 MYO9B NOD2 TNF
5 ulcerative colitis 29.8 MYO9B NOD2 TNF
6 acquired immunodeficiency syndrome 29.6 IL2RA TNF
7 inflammatory bowel disease 29.0 DLG5 MYO9B NOD2 TNF
8 intussusception 10.7
9 lymphoma 10.2
10 chronic graft versus host disease 10.2 IL2RA TNF
11 anterior uveitis 10.2 IL2RA TNF
12 intermediate uveitis 10.1 IL2RA TNF
13 posterior uveitis 10.1 IL2RA TNF
14 stromal keratitis 10.1 IL2RA TNF
15 oligoarticular juvenile idiopathic arthritis 10.1 IL2RA TNF
16 idiopathic neutropenia 10.1 IL2RA TNF
17 brucellosis 10.1 IL2RA TNF
18 mumps 10.1 IL2RA TNF
19 intestinal obstruction 10.1
20 pulmonary sarcoidosis 10.1 IL2RA TNF
21 granulomatous dermatitis 10.1 NOD2 TNF
22 streptococcal meningitis 10.1 NOD2 TNF
23 spondylarthropathy 10.1 NOD2 TNF
24 inflammatory bowel disease 3 10.1 NOD2 TNF
25 orofacial granulomatosis 10.1 NOD2 TNF
26 chronic mucocutaneous candidiasis 10.1 IL2RA TNF
27 blau syndrome 10.1 NOD2 TNF
28 hidradenitis suppurativa 10.1 NOD2 TNF
29 hidradenitis 10.1 NOD2 TNF
30 pyoderma 10.1 NOD2 TNF
31 pyoderma gangrenosum 10.0 NOD2 TNF
32 burkitt lymphoma 10.0
33 appendicitis 10.0
34 melkersson-rosenthal syndrome 10.0 NOD2 TNF
35 hypersensitivity reaction type iv disease 10.0 NOD2 TNF
36 q fever 10.0 NOD2 TNF
37 uveal disease 10.0 NOD2 TNF
38 juvenile rheumatoid arthritis 10.0 IL2RA TNF
39 leprosy 3 10.0 NOD2 TNF
40 inflammatory bowel disease 6 10.0 MYO9B NOD2
41 spondyloarthropathy 1 10.0 NOD2 TNF
42 familial mediterranean fever 10.0 NOD2 TNF
43 colorectal cancer 10.0
44 lipomatosis, multiple 10.0
45 gastrointestinal stromal tumor 10.0
46 pleomorphic lipoma 10.0
47 megacolon 10.0
48 melanoma 10.0
49 endometriosis 10.0
50 lymphadenitis 10.0 NOD2 TNF

Graphical network of the top 20 diseases related to Ileocolitis:



Diseases related to Ileocolitis

Symptoms & Phenotypes for Ileocolitis

Symptoms:

12
  • weight loss
  • diarrhea
  • abdominal pain in middle or lower right part

GenomeRNAi Phenotypes related to Ileocolitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 IL2RA MYO9B NOD2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 IL2RA MYO9B NOD2 TNF

MGI Mouse Phenotypes related to Ileocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.46 GPX1 IL2RA NOD2 TNF
2 hematopoietic system MP:0005397 9.43 DLG5 GPX1 IL2RA MYO9B NOD2 TNF
3 homeostasis/metabolism MP:0005376 9.1 DLG5 DNAJC17 GPX1 IL2RA NOD2 TNF

Drugs & Therapeutics for Ileocolitis

Drugs for Ileocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 3 446-86-6 2265
2
Certolizumab pegol Approved Phase 3 428863-50-7
3
Adalimumab Approved Phase 3 331731-18-1 16219006
4 Antimetabolites, Antineoplastic Phase 3
5 Immunologic Factors Phase 3
6 Immunosuppressive Agents Phase 3
7 Antirheumatic Agents Phase 3
8 Antimetabolites Phase 3
9 Nucleic Acid Synthesis Inhibitors Phase 3
10 6-Mercaptopurine Phase 3
11 Anti-Inflammatory Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease Unknown status NCT01817972 Phase 3 Azathioprine
2 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
3 Safety Study of P28GST Treatment in Crohn's Disease Patients Completed NCT02281916 Phase 2 P28GST
4 Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis Recruiting NCT03256240 Not Applicable

Search NIH Clinical Center for Ileocolitis

Genetic Tests for Ileocolitis

Anatomical Context for Ileocolitis

MalaCards organs/tissues related to Ileocolitis:

41
Skin, Colon, Eye, Pituitary, Heart, B Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Ileocolitis:

19
Colon, Ileum

Publications for Ileocolitis

Articles related to Ileocolitis:

(show top 50) (show all 110)
# Title Authors Year
1
The Comb Sign in Crohn's Ileocolitis. ( 29532298 )
2018
2
A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab. ( 29552363 )
2018
3
Obstructive Ileocolitis in Patients With Obstructed Colorectal Cancer - A Matched Case Control Study. ( 30208680 )
2018
4
Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. ( 28647362 )
2017
5
Ipilimumab-induced hypophysitis and ileocolitis: Serial pituitary MRI findings. ( 28084260 )
2017
6
Concomitant Laparoscopic Ileocolectomy and Ladds Procedure for Crohns Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27930275 )
2016
7
A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. ( 27767057 )
2016
8
Fatal Campylobacter jejuni ileocolitis. ( 27701889 )
2016
9
Concomitant Laparoscopic Ileocolectomy and Ladd's Procedure for Crohn's Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27670550 )
2016
10
Concomitant Laparoscopic Ileocolectomy and Ladd's Procedure for Crohn's Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 30454187 )
2016
11
P286. Prevalence of Ulcerative Colitis and Crohn ileocolitis in patients with celiac disease. ( 25717762 )
2015
12
Cytomegalovirus ileocolitis in a rheumatoid arthritis patient: case report and literature review. ( 26150269 )
2015
13
Ulcerating Ileocolitis in Severe Amatoxin Poisoning. ( 26357578 )
2015
14
Eosinophilic ileocolitis due to Enterobius vermicularis infection: a rare cause of anemia. ( 25976928 )
2015
15
Abdominal pain and ileocolitis in a 51-year-old woman. ( 25529814 )
2015
16
Indolent systemic mastocytosis in a patient with ileocolitis. ( 24975749 )
2014
17
Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2. ( 24374371 )
2014
18
Historical note on Crohn's disease: first US pre-eponym journal report of chronic regional ileocolitis in 1813. ( 23269223 )
2013
19
Diarrhoea in a patient with metastatic melanoma: Ipilimumab ileocolitis treated with infliximab. ( 23919220 )
2013
20
Identification of unique gene expression profile in children with regressive autism spectrum disorder (ASD) and ileocolitis. ( 23520485 )
2013
21
Idiopathic ileocolitis with perforation associated with HIV infection: thalidomide treatment. ( 23155107 )
2012
22
Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. ( 22178590 )
2012
23
Rituximab-induced immunodysregulatory ileocolitis in a patient with follicular lymphoma. ( 21098319 )
2011
24
Coeliac disease and granulomatous ileocolitis: an association or chance occurrence? ( 22184569 )
2011
25
Ischemic versus non-ischemic obstructive ileocolitis secondary to colorectal cancer: a review of 393 cases. ( 20460267 )
2010
26
Yersinia enterocolitica ileocolitis in beta-thalassemic patients. ( 16784477 )
2006
27
Common variable immunodeficiency masquerading as Crohn's ileocolitis. ( 16432382 )
2006
28
Cytomegalovirus infection in a patient with Crohn's ileocolitis. ( 15729431 )
2005
29
Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn's ileocolitis depending on disease activity and localization. ( 13680283 )
2004
30
Ileocolitis associated with Anaerobiospirillum in cats. ( 15184462 )
2004
31
BehAset's ileocolitis: successful treatment with tumor necrosis factor-alpha antibody (infliximab) therapy: report of a case. ( 12544532 )
2003
32
Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study. ( 11559654 )
2001
33
Kaposi's sarcoma and cytomegaloviral ileocolitis complicating long-standing Crohn's disease in an HIV-negative patient. ( 11693345 )
2001
34
Eosinophilic ileocolitis secondary to Enterobius vermicularis: case report. ( 10931992 )
2000
35
Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. ( 9869598 )
1999
36
Management of severe colitis/ileocolitis. ( 9741027 )
1998
37
Cyclic neutropenia in Crohn's ileocolitis: efficacy of granulocyte colony-stimulating factor. ( 9252852 )
1997
38
Eosinophilic ileocolitis by Enterobius vermicularis: a description of two rare cases. ( 9265579 )
1997
39
Cytomegalovirus ileocolitis: different manifestations of the same illness in the terminal ileum and colon. ( 8934098 )
1996
40
Leucocyte adhesion deficiency presenting as a chronic ileocolitis. ( 8944573 )
1996
41
Comparison between high dose 5-aminosalicylic acid and 6-methylprednisolone in active Crohn's ileocolitis. A multicenter randomized double-blind study. German 5-ASA Study Group. ( 7502549 )
1995
42
Treatment of active Crohn's ileocolitis with oral pH-modified budesonide. Germany Budesonide Study Group. ( 7610691 )
1995
43
Positive In-111 WBC scan in a patient with ischemic ileocolitis and negative colonoscopies. ( 7648726 )
1995
44
Oral 4-aminosalicylic acid versus 5-aminosalicylic acid slow release tablets. Double blind, controlled pilot study in the maintenance treatment of Crohn's ileocolitis. ( 7926910 )
1994
45
A randomized, double-blind, placebo-controlled trial of the oral mesalamine (5-ASA) preparation, Asacol, in the treatment of symptomatic Crohn's colitis and ileocolitis. ( 7876505 )
1994
46
Spontaneous portal venous gas in a patient with Crohn's ileocolitis. ( 1991607 )
1991
47
Voltaren (diclofenac sodium)-induced ileocolitis. ( 1992644 )
1991
48
Life-threatening diarrhea after short-term misoprostol use in a patient with Crohn ileocolitis. ( 2117413 )
1990
49
Focal ulcerative ileocolitis with terminal thrombocytopenic purpura in juvenile cotton top tamarins (Saguinus oedipus). ( 2496272 )
1989
50
Crohn's ileocolitis presenting as chronic diffuse hair loss. ( 2754688 )
1989

Variations for Ileocolitis

Expression for Ileocolitis

Search GEO for disease gene expression data for Ileocolitis.

Pathways for Ileocolitis

GO Terms for Ileocolitis

Biological processes related to Ileocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.63 DLG5 MYO9B NOD2
2 positive regulation of JNK cascade GO:0046330 9.48 NOD2 TNF
3 cellular response to organic cyclic compound GO:0071407 9.43 NOD2 TNF
4 regulation of inflammatory response GO:0050727 9.4 NOD2 TNF
5 positive regulation of MAP kinase activity GO:0043406 9.37 NOD2 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.32 NOD2 TNF
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.26 NOD2 TNF
8 JNK cascade GO:0007254 9.16 NOD2 TNF
9 negative regulation of T cell proliferation GO:0042130 8.96 DLG5 IL2RA
10 positive regulation of interleukin-8 production GO:0032757 8.62 NOD2 TNF

Sources for Ileocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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