Aliases & Classifications for Ileocolitis

MalaCards integrated aliases for Ileocolitis:

Name: Ileocolitis 12 15 17
Iieocolitis 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060190
ICD10 32 K52.9
UMLS 70 C0949272

Summaries for Ileocolitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon and located in ileum, has symptom diarrhea, has symptom weight loss, has symptom abdominal pain in middle or lower right part.

MalaCards based summary : Ileocolitis, also known as iieocolitis, is related to crohn's disease and ileitis, and has symptoms including weight loss, diarrhea and abdominal pain in middle. An important gene associated with Ileocolitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Glutathione metabolism and Folate Metabolism. The drugs Loperamide and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include colon, ileum and small intestine, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 73 Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the... more...

Related Diseases for Ileocolitis

Diseases related to Ileocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 30.5 TNF NOD2 IL2RA ATG16L1
2 ileitis 30.4 TNF NOD2 ATG16L1
3 crohn's colitis 30.3 TNF NOD2 ATG16L1
4 ulcerative colitis 30.2 TNF NOD2 DUOX2 ATG16L1
5 colitis 30.1 TNF NOD2 DUOX2 ATG16L1
6 intestinal tuberculosis 30.1 TNF NOD2
7 sarcoidosis 1 29.8 TNF NOD2 IL2RA
8 common variable immunodeficiency 29.5 XBP1 TNF NOD2 IL2RA
9 inflammatory bowel disease 28.7 XBP1 TNF ORMDL3 NOX1 NOD2 IL2RA
10 sigmoid disease 10.3 TNF NOD2
11 kashin-beck disease 10.3 TNF GPX1
12 gastroduodenal crohn's disease 10.3 TNF NOD2
13 diarrhea 10.3
14 pouchitis 10.3 TNF NOD2
15 gastrointestinal tuberculosis 10.3 TNF NOD2
16 orofacial granulomatosis 10.3 TNF NOD2
17 chemical colitis 10.3 TNF NOD2
18 tenosynovitis 10.2 TNF NOD2
19 oligoarticular juvenile idiopathic arthritis 10.2 TNF IL2RA
20 granulomatous dermatitis 10.2 TNF NOD2
21 inflammatory bowel disease 9 10.2 PLA2G4F NOD2
22 acute graft versus host disease 10.2 TNF NOD2 IL2RA
23 iritis 10.2 TNF NOD2
24 lymphadenitis 10.2 TNF NOD2 IL2RA
25 chorioretinitis 10.2 TNF NOD2
26 choroiditis 10.1 TNF NOD2
27 uveitis 10.1 TNF NOD2 IL2RA
28 idiopathic neutropenia 10.1 TNF IL2RA
29 inflammatory bowel disease 6 10.1 NOD2 ATG16L1
30 uveoparotid fever 10.0 TNF NOD2 ATG16L1
31 anorectal stricture 10.0 TNF NOD2 ATG16L1
32 gastroenteritis 10.0
33 salmonellosis 10.0 TNF NOD2 ATG16L1
34 inflammatory bowel disease 18 10.0 NOD2 ATG16L1
35 autoimmune disease of gastrointestinal tract 10.0 TNF NOD2 ATG16L1
36 granulomatous disease, chronic, autosomal recessive, 4 10.0 NOX1 GPX2 GPX1 DUOX2
37 glutathione peroxidase deficiency 10.0 GPX3 GPX1
38 inflammatory bowel disease 1 10.0 PLA2G4F NOD2 ATG16L1
39 tuberculoid leprosy 10.0 TNF IL2RA
40 autism 9.9
41 enterocolitis 9.9
42 autism spectrum disorder 9.9
43 microscopic colitis 9.9
44 human cytomegalovirus infection 9.9
45 eosinophilic gastroenteritis 9.9
46 intestinal obstruction 9.9
47 inflammatory bowel disease 5 9.9 NOD2 ATG16L1
48 celiac disease 1 9.9 TNF NOD2 IL2RA ATG16L1
49 colorectal cancer 9.8
50 kaposi sarcoma 9.8

Graphical network of the top 20 diseases related to Ileocolitis:



Diseases related to Ileocolitis

Symptoms & Phenotypes for Ileocolitis

Symptoms:

12
  • weight loss
  • diarrhea
  • abdominal pain in middle

MGI Mouse Phenotypes related to Ileocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.02 AGR2 ATG16L1 ERN2 GPX1 GPX2 IL2RA
2 endocrine/exocrine gland MP:0005379 9.91 AGR2 ATG16L1 DUOX2 GPX1 GPX2 GPX4
3 hematopoietic system MP:0005397 9.85 AGR2 ATG16L1 DUOX2 GPX1 GPX3 IL2RA
4 homeostasis/metabolism MP:0005376 9.8 AGR2 ATG16L1 DNAJC17 DUOX2 GPX1 GPX2
5 immune system MP:0005387 9.4 AGR2 ATG16L1 DUOX2 ERN2 GPX1 GPX2

Drugs & Therapeutics for Ileocolitis

Drugs for Ileocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 4 53179-11-6 3955
2
Metronidazole Approved Phase 4 443-48-1 4173
3 Cola Phase 4
4 Antidiarrheals Phase 4
5 Gastrointestinal Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Antiparasitic Agents Phase 4
8 Anti-Bacterial Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Antiprotozoal Agents Phase 4
11
Infliximab Approved 170277-31-3
12 Anesthetics

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Laparoscope Subtotal Colectomy With Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation Completed NCT02147574 Phase 4
2 Does the Microbiome Change With Flagyl Treatment After Ileocolic Resection for Crohn's Disease Recruiting NCT04682522 Phase 4 Metronidazole Oral
3 Role of CT Angiography With Three-dimensional Reconstruction of Mesenteric Vessels in Planning and Performing of Laparoscopic Colorectal Resections Completed NCT01540448 Phase 3
4 Safety Study of P28GST Treatment in Crohn's Disease Patients, a Multicenter Phase 2 Clinical Trial Completed NCT02281916 Phase 2 P28GST
5 Intracorporeal or Extracorporeal Ileocolic Anastomosis After Laparoscopic Right Colectomy. Unknown status NCT03045107
6 The Role of Small Bowel Ultrasound After Ileocolic Resection or When Starting Infliximab in Crohn's Disease Patients Unknown status NCT02330458
7 Comparison of Endoscopy and Diffusion-weighted Enterography-MRI for the Diagnosis of Crohn's Disease Recurrence Following Ileocolic Resection: a Pilot Study Unknown status NCT02867540
8 INtracorporeal Versus EXTracorpoREal anastoMOsis After Laparoscopic Right Colectomy for Cancer: a Randomized Clinical Trial. (IN EXTREMO Study) Unknown status NCT01679756
9 Multicenter National Observational Study on Intracorporeal Versus Extracorporeal Technique for Ileocolic Anastomosis in Laparoscopic Right Hemicolectomy Completed NCT03934151
10 Assessing the Feasibility and Safety of Using Intraoperative Ultrasound in Ileocolic Crohn's Disease - The IUSS Crohn's Feasibility Study Completed NCT03939117
11 Risk Factors of Complications After Ileocolic Resection for Crohn Disease According to the Comprehensive Complication Index - RICCI Completed NCT03846778
12 Post-operative CRP Monitoring After Ileo-colic Resection in Crohn's Disease Patients Completed NCT04643496
13 Minimally Invasive Open Technique for Ileo-colic Resection in Complex Cases of Terminal Ileum Crohn's Disease. Case Series. Completed NCT03950726
14 Intracorporeal Vs Extracorporeal Anastomosis in Patients Undergoing Laparoscopic Right Hemicolectomy: a Multicenter Randomized Clinical Trial (The IVEA-study) Completed NCT03990714
15 Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease: A Multicenter Prospective Cohort Study Recruiting NCT04539665
16 A Prospective Randomized Controlled Clinical Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440
17 Post-operative CRP Trend May Lead to Early Diagnosis of Anastomotic Leak After Ileocolic Resection in Crohn's Disease Patients. Recruiting NCT04739579
18 MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES) Recruiting NCT04578392
19 Mesenteric SParIng Versus Central mesenterectomY in Ileocolic Resection for Terminal Ileitis in Crohn's Disease Recruiting NCT04538638
20 Prospective Pilot Study for the Efficacy and Security Analysis in the Protection of Ileocolic Anastomosis Conducted in Laparoscopic Right Hemicolectomy Because of Colon Cancer, Using a Using a NHS-PEG (N-hydroxysuccinimide Functionalized Polyethylene Glycol) Coated Collagen Patch. Recruiting NCT04109105
21 Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease: A Multicenter Prospective Cohort Study Recruiting NCT04266600
22 A Multi-Center Prospective Comparison of Intracorporeal and Extracorporeal Anastomoses for Minimally Invasive Right Colectomy Active, not recruiting NCT03312569
23 Mesenteric Sparing Versus High Ligation Ileocolic Resection for the Prevention of Recurrent Crohn's Disease Terminated NCT03172143
24 Crohn's Extent of Resection Trial (CERT): A Randomised Controlled Trial Comparing Anastomotic Disease Recurrence Following 2cm Versus 10cm Resection Margins for Patients With Ileocolic Crohn's Disease Withdrawn NCT01876264

Search NIH Clinical Center for Ileocolitis

Genetic Tests for Ileocolitis

Anatomical Context for Ileocolitis

The Foundational Model of Anatomy Ontology organs/tissues related to Ileocolitis:

19
Colon, Ileum

MalaCards organs/tissues related to Ileocolitis:

40
Colon, Small Intestine, Bone Marrow, Spinal Cord, Skin, Appendix, Pituitary

Publications for Ileocolitis

Articles related to Ileocolitis:

(show top 50) (show all 432)
# Title Authors PMID Year
1
Clinical and Anthropometric Improvements with a Tailored Dietary Approach in Pediatric Crohn's Disease. 61
33711815 2021
2
Clinical characteristics and long-term outcome of E. coli-associated granulomatous ileocolitis in dogs: five cases (2010-2014). 61
33660270 2021
3
Cytomegalovirus enterocolitis with subsequent diagnosis of coexisting new-onset inflammatory bowel disease: Two case reports and review of the literature. 61
33663126 2021
4
Rituximab-induced Ileocolitis in a Patient with Gastric MALToma: A Case Report and Literature Review. 61
33642561 2021
5
Infliximab Drug-Induced Autoimmune Hepatitis in a Patient With Crohn's Ileocolitis. 61
33416253 2020
6
[Ileocolitis in an immunocompromised patient. Crohn's disease or an infection?] 61
33332027 2020
7
Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease-Glutathione peroxide isoenzymes 1 and 2-double knockout mice on a C57BL background. 61
32810389 2020
8
Role of platelets in neonatal necrotizing enterocolitis. 61
32601461 2020
9
Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis. 61
32366656 2020
10
[Vedolizumab in patients with inflammatory bowel diseases of in real clinical practice]. 61
32598721 2020
11
Juvenile “idiopathic†arthritis (JIA) as a manifestation of food allergy. Case study. 61
32876635 2020
12
Rare paradoxical adverse event in Crohn's disease: a case report. 61
32175426 2020
13
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn's Disease-Like Inflammation. 61
31276162 2020
14
Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2. 61
31689440 2019
15
Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate. 61
31411503 2019
16
The use of fecal calprotectin in monitoring activity of inflammatory bowel diseases. 61
31094477 2019
17
Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. 61
30948494 2019
18
Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn's disease: comparison with magnetic resonance enterography. 61
30962408 2019
19
Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome. 61
30774408 2019
20
Differential diagnosis of inflammatory bowel disease: imitations and complications. 61
30102183 2018
21
Obstructive Ileocolitis in Patients With Obstructed Colorectal Cancer - A Matched Case Control Study. 61
30208680 2018
22
The prevalence and phenotype in Brazilian patients with inflammatory bowel disease. 61
29914399 2018
23
Hepatic portal venous gas due to polystyrene sulfonate-induced enteritis. 61
29356959 2018
24
The Comb Sign in Crohn's Ileocolitis. 61
29532298 2018
25
A comprehensive review and update on Crohn's disease. 61
28826742 2018
26
Obesity/Bariatric Surgery and Crohn's Disease. 61
28489647 2018
27
A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab. 61
29552363 2018
28
Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. 61
28647362 2017
29
AGR2 ameliorates tumor necrosis factor-α-induced epithelial barrier dysfunction via suppression of NF-κB p65-mediated MLCK/p-MLC pathway activation. 61
28339048 2017
30
Rituximab-induced Crohn's disease. 61
28129697 2017
31
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium. 61
27930931 2017
32
Level of Fecal Calprotectin Correlates With Severity of Small Bowel Crohn's Disease, Measured by Balloon-assisted Enteroscopy and Computed Tomography Enterography. 61
27565523 2017
33
Early Intervention with Infliximab Prevents Reoperation in Crohn's Disease: A Single-Center Retrospective Analysis. 61
28858864 2017
34
Ipilimumab-induced hypophysitis and ileocolitis: Serial pituitary MRI findings. 61
28084260 2017
35
Fatal Campylobacter jejuni ileocolitis. 61
27701889 2016
36
A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. 61
27767057 2016
37
Concomitant Laparoscopic Ileocolectomy and Ladd's Procedure for Crohn's Ileocolitis with Mesenteric Abscess and Congenital Megacolon. 61
27670550 2016
38
Primary Adenocarcinoma of an Ileostomy in Crohn's Disease. 61
27622191 2016
39
[Epidemiological and clinical characteristics of inflammatory bowel disease in a tertiary referral hospital in Lima-Peru]. 61
27716757 2016
40
Eosinophilic ileocolitis due to Enterobius vermicularis infection: a rare cause of anemia. 61
25976928 2016
41
[CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF INTESTINAL LESIONS IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS]. 61
30284417 2016
42
Isolated ileitis associated with primary sclerosing cholangitis in three patients with Crohn's disease. 61
26806276 2016
43
Assessment of a Colonoscopy Triage Sheet for Use in a Province-Wide Population-Based Colorectal Screening Program. 61
27446841 2016
44
Cytomegalovirus ileocolitis in a rheumatoid arthritis patient: case report and literature review. 61
26150269 2015
45
Efficacy of concomitant elemental diet therapy in scheduled infliximab therapy in patients with Crohn's disease to prevent loss of response. 61
25532505 2015
46
The role of US in finding intussusception and alternative diagnosis: a report of 100 pediatric cases. 61
24526755 2015
47
Abdominal pain and ileocolitis in a 51-year-old woman. 61
25529814 2015
48
[PEDIATRIC GASTROENTEROLOGY: ORIGINS, PROBLEMS, AND PROSPECTS OF THE RESEARCH]. 61
26281153 2015
49
Ulcerating Ileocolitis in Severe Amatoxin Poisoning. 61
26357578 2015
50
A rare complication of CMV infection in Crohn's disease - hemophagocytic syndrome: a case report. 61
26743306 2015

Variations for Ileocolitis

Expression for Ileocolitis

Search GEO for disease gene expression data for Ileocolitis.

Pathways for Ileocolitis

GO Terms for Ileocolitis

Cellular components related to Ileocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADPH oxidase complex GO:0043020 8.62 NOX1 DUOX2

Biological processes related to Ileocolitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.85 NOX1 GPX4 GPX3 GPX2 GPX1 DUOX2
2 regulation of inflammatory response GO:0050727 9.71 TNF NOD2 GPX4
3 positive regulation of interleukin-6 production GO:0032755 9.7 XBP1 TNF NOD2
4 response to endoplasmic reticulum stress GO:0034976 9.69 XBP1 ERN2 AGR2
5 positive regulation of JNK cascade GO:0046330 9.67 TNF NOX1 NOD2
6 phospholipid metabolic process GO:0006644 9.65 PLA2G4F PLA2G4E GPX4
7 cellular response to organic cyclic compound GO:0071407 9.63 TNF PLA2G4F NOD2
8 defense response GO:0006952 9.62 TNF NOX1 NOD2 DUOX2
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.61 TNF NOD2
10 phosphatidylserine acyl-chain remodeling GO:0036150 9.61 PLA2G4F PLA2G4E
11 positive regulation of autophagy GO:0010508 9.61 XBP1 ORMDL3 ATG16L1
12 phospholipid catabolic process GO:0009395 9.6 PLA2G4F PLA2G4E
13 positive regulation of T cell differentiation GO:0045582 9.59 XBP1 IL2RA
14 phosphatidylinositol acyl-chain remodeling GO:0036149 9.58 PLA2G4F PLA2G4E
15 superoxide anion generation GO:0042554 9.58 NOX1 DUOX2
16 lipoxygenase pathway GO:0019372 9.57 GPX4 GPX1
17 glycerophospholipid catabolic process GO:0046475 9.56 PLA2G4F PLA2G4E
18 negative regulation of inflammatory response to antigenic stimulus GO:0002862 9.55 NOD2 GPX1
19 cellular response to oxidative stress GO:0034599 9.46 XBP1 GPX3 GPX2 GPX1
20 hydrogen peroxide catabolic process GO:0042744 9.43 GPX3 GPX1 DUOX2
21 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.4 TNF NOD2
22 response to oxidative stress GO:0006979 9.35 GPX4 GPX3 GPX2 GPX1 DUOX2
23 cellular oxidant detoxification GO:0098869 9.02 GPX4 GPX3 GPX2 GPX1 DUOX2

Molecular functions related to Ileocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 NOX1 GPX4 GPX3 GPX2 GPX1 DUOX2
2 calcium-dependent phospholipase A2 activity GO:0047498 9.4 PLA2G4F PLA2G4E
3 superoxide-generating NADPH oxidase activity GO:0016175 9.37 NOX1 DUOX2
4 selenium binding GO:0008430 9.32 GPX4 GPX3
5 glutathione peroxidase activity GO:0004602 9.26 GPX4 GPX3 GPX2 GPX1
6 phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 9.16 GPX4 GPX1
7 peroxidase activity GO:0004601 9.02 GPX4 GPX3 GPX2 GPX1 DUOX2

Sources for Ileocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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