Aliases & Classifications for Ileocolitis

MalaCards integrated aliases for Ileocolitis:

Name: Ileocolitis 12 15
Iieocolitis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060190
ICD10 33 K52.9
UMLS 73 C0949272

Summaries for Ileocolitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon and located in ileum, has symptom diarrhea, has symptom weight loss, has symptom abdominal pain in middle or lower right part.

MalaCards based summary : Ileocolitis, also known as iieocolitis, is related to cytomegalovirus infection and crohn's colitis, and has symptoms including diarrhea, weight loss and abdominal pain in middle or lower right part. An important gene associated with Ileocolitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are NF-kappaB Signaling and Th17 cell differentiation. The drugs Azathioprine and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include colon, ileum and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Crohn\'s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

Related Diseases for Ileocolitis

Diseases related to Ileocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 cytomegalovirus infection 30.1 IL2RA TNF
2 crohn's colitis 29.8 NOD2 TNF
3 ileitis 29.6 NOD2 TNF
4 colitis 29.2 MYO9B NOD2 TNF
5 crohn's disease 29.2 DLG5 NOD2 TNF
6 ulcerative colitis 28.9 MYO9B NOD2 TNF
7 intussusception 10.5
8 posterior uveitis 10.5 IL2RA TNF
9 intermediate uveitis 10.5 IL2RA TNF
10 oligoarticular juvenile idiopathic arthritis 10.5 IL2RA TNF
11 stromal keratitis 10.4 IL2RA TNF
12 idiopathic neutropenia 10.3 IL2RA TNF
13 brucellosis 10.3 IL2RA TNF
14 pulmonary sarcoidosis 10.3 IL2RA TNF
15 granulomatous dermatitis 10.2 NOD2 TNF
16 inflammatory bowel disease 3 10.2 NOD2 TNF
17 orofacial granulomatosis 10.2 NOD2 TNF
18 streptococcal meningitis 10.2 NOD2 TNF
19 blau syndrome 10.2 NOD2 TNF
20 hidradenitis suppurativa 10.2 NOD2 TNF
21 hidradenitis 10.2 NOD2 TNF
22 pyoderma gangrenosum 10.1 NOD2 TNF
23 pyoderma 10.1 NOD2 TNF
24 lymphoma 10.1
25 q fever 10.1 NOD2 TNF
26 hypersensitivity reaction type iv disease 10.1 NOD2 TNF
27 juvenile rheumatoid arthritis 10.1 IL2RA TNF
28 leprosy 3 10.1 NOD2 TNF
29 spondyloarthropathy 1 10.0 NOD2 TNF
30 alopecia areata 10.0 IL2RA TNF
31 inflammatory bowel disease 6 10.0 MYO9B NOD2
32 lymphadenitis 10.0 NOD2 TNF
33 familial mediterranean fever 10.0 NOD2 TNF
34 intestinal obstruction 9.9
35 intestinal disease 9.9 NOD2 TNF
36 rheumatic disease 9.9 IL2RA TNF
37 spondylitis 9.9 NOD2 TNF
38 burkitt lymphoma 9.9
39 sarcoma 9.9
40 autism 9.8
41 aging 9.8
42 autism spectrum disorder 9.8
43 megacolon 9.8
44 melanoma 9.8
45 gastroenteritis 9.8
46 endometriosis 9.8
47 duodenal obstruction 9.8
48 eosinophilic gastroenteritis 9.8
49 duodenitis 9.8
50 eosinophilic enteropathy 9.8

Graphical network of the top 20 diseases related to Ileocolitis:



Diseases related to Ileocolitis

Symptoms & Phenotypes for Ileocolitis

Symptoms:

12
  • diarrhea
  • weight loss
  • abdominal pain in middle or lower right part

GenomeRNAi Phenotypes related to Ileocolitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 IL2RA MYO9B NOD2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 TNF IL2RA MYO9B NOD2

MGI Mouse Phenotypes related to Ileocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.46 TNF GPX1 IL2RA NOD2
2 hematopoietic system MP:0005397 9.43 DLG5 GPX1 IL2RA MYO9B NOD2 TNF
3 homeostasis/metabolism MP:0005376 9.1 DLG5 DNAJC17 GPX1 IL2RA NOD2 TNF

Drugs & Therapeutics for Ileocolitis

Drugs for Ileocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 3 446-86-6 2265
2
Certolizumab pegol Approved Phase 3 428863-50-7
3
Adalimumab Approved Phase 3 331731-18-1 16219006
4 Antimetabolites Phase 3
5 Antimetabolites, Antineoplastic Phase 3
6 Antirheumatic Agents Phase 3
7 Immunosuppressive Agents Phase 3
8 6-Mercaptopurine Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease Unknown status NCT01817972 Phase 3 Azathioprine
2 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
3 Safety Study of P28GST Treatment in Crohn's Disease Patients Completed NCT02281916 Phase 2 P28GST
4 Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis Recruiting NCT03256240 Not Applicable

Search NIH Clinical Center for Ileocolitis

Genetic Tests for Ileocolitis

Anatomical Context for Ileocolitis

The Foundational Model of Anatomy Ontology organs/tissues related to Ileocolitis:

19
Colon, Ileum

MalaCards organs/tissues related to Ileocolitis:

41
Skin, Colon, Eye, Pituitary, Small Intestine, Lymph Node

Publications for Ileocolitis

Articles related to Ileocolitis:

(show top 50) (show all 126)
# Title Authors Year
1
The incidence of negative intraoperative findings after unsuccessful hydrostatic reduction of ileocolic intussusception in children: A retrospective analysis. ( 29866482 )
2018
2
The Comb Sign in Crohn's Ileocolitis. ( 29532298 )
2018
3
Fever as a Presenting Symptom in Children Evaluated for Ileocolic Intussusception: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337836 )
2018
4
A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab. ( 29552363 )
2018
5
Microcytic anemia due to ileocolic anastomotic ulcer. ( 29588085 )
2018
6
Ileocolic intussusception: Predicting the probability of success of ultrasound guided saline enema from clinical and sonographic data. ( 29150367 )
2018
7
Updating predictors of endoscopic recurrence after ileocolic resection for Crohn disease. ( 28594329 )
2017
8
Manual laparoscopy-assisted intraoperative reduction for adult ileocolic intussusception with ileal adenoma: A case report. ( 28554107 )
2017
9
Granulomas in mesenteric lymph nodes in Crohn's disease patients with ileocolic resection are areassociated with younger age and transmural inflammation. ( 28087973 )
2017
10
Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. ( 28647362 )
2017
11
Ipilimumab-induced hypophysitis and ileocolitis: Serial pituitary MRI findings. ( 28084260 )
2017
12
Intestinal Obstruction Caused by Ileocolic and Colocolic Intussusception in an Adult Patient with Cecal Lipoma. ( 28044120 )
2016
13
Intestinal Obstruction and Ileocolic Fistula due to Intraluminal Migration of a Gossypiboma. ( 26989551 )
2016
14
Concomitant Laparoscopic Ileocolectomy and Ladds Procedure for Crohns Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27930275 )
2016
15
A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. ( 27767057 )
2016
16
Giant ileocolic intussusception in an adult induced by a double ileal lipoma: a case report with pathologic correlation. ( 27594938 )
2016
17
Adult ileocolic intussusception caused by Burkitt lymphoma. ( 27920022 )
2016
18
Use of a linear stapler for the treatment of ileocolic fistula in Crohn's disease. ( 27454329 )
2016
19
Fatal Campylobacter jejuni ileocolitis. ( 27701889 )
2016
20
Concomitant Laparoscopic Ileocolectomy and Ladd's Procedure for Crohn's Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27670550 )
2016
21
P286. Prevalence of Ulcerative Colitis and Crohn ileocolitis in patients with celiac disease. ( 25717762 )
2015
22
Cytomegalovirus ileocolitis in a rheumatoid arthritis patient: case report and literature review. ( 26150269 )
2015
23
Ulcerating Ileocolitis in Severe Amatoxin Poisoning. ( 26357578 )
2015
24
Ileocaecal Lymphoma Presenting as Ileocolic Intussesception in a 7 Year Old Male. ( 27217691 )
2015
25
Eosinophilic ileocolitis due to Enterobius vermicularis infection: a rare cause of anemia. ( 25976928 )
2015
26
Abdominal pain and ileocolitis in a 51-year-old woman. ( 25529814 )
2015
27
Fecal Microbial Transplant After Ileocolic Resection Reduces Ileitis but Restores Colitis in IL-10-/- Mice. ( 26070001 )
2015
28
Indolent systemic mastocytosis in a patient with ileocolitis. ( 24975749 )
2014
29
An ileal duplication cyst manifested as an ileocolic intussusception in an adult. ( 25910304 )
2014
30
Factors influencing disease recurrence after ileocolic resection in adult and pediatric onset Crohn's disease. ( 25110291 )
2014
31
Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2. ( 24374371 )
2014
32
Laparoscopic ileocolic resection for Crohn's disease associated with midgut malrotation. ( 25419109 )
2014
33
Transverse incisions for resection of ileocolic Crohn's disease. ( 23461954 )
2013
34
Ileocolic intussusception due to Burkitt lymphoma: a case report. ( 23599821 )
2013
35
Endoscopic treatment of a symptomatic ileal lipoma with recurrent ileocolic intussusceptions by using cap-assisted colonoscopy. ( 23964343 )
2013
36
Total ileocolic intussusception with rectal prolapse presenting in an adult: a case report and review of the literature. ( 24059349 )
2013
37
Adenocarcinoma of the ileocolic junction and multifocal hepatic sarcomas in an aged rhesus macaque (Macaca mulatta). ( 24209973 )
2013
38
Ileocolic intussusception secondary to a type II low-grade appendiceal mucinous neoplasm. ( 23351140 )
2013
39
Single port laparoscopic right hemicolectomy for ileocolic intussusception. ( 23538552 )
2013
40
Successful treatment of ileocolic intussusception with air enema reduction in an adult patient. ( 24332898 )
2013
41
Ileocolic versus small-bowel intussusception in children: can US enable reliable differentiation? ( 23801771 )
2013
42
Historical note on Crohn's disease: first US pre-eponym journal report of chronic regional ileocolitis in 1813. ( 23269223 )
2013
43
Crohn's disease recurrence in patients with ileocolic anastomosis: value of computed tomography enterography with water enema. ( 23727378 )
2013
44
Ileocolic to right iliac arterial transposition for the treatment of chronic mesenteric ischemia. ( 24436624 )
2013
45
Diarrhoea in a patient with metastatic melanoma: Ipilimumab ileocolitis treated with infliximab. ( 23919220 )
2013
46
Identification of unique gene expression profile in children with regressive autism spectrum disorder (ASD) and ileocolitis. ( 23520485 )
2013
47
Therapeutic enema for pediatric ileocolic intussusception: using a balloon catheter improves efficacy. ( 23748969 )
2013
48
Gastrointestinal Kaposi's Sarcoma Presenting as Ileocolic Intussusception. ( 24404547 )
2013
49
Catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route for acute portal venous thrombosis: report of two cases. ( 23007968 )
2013
50
Ileocolic intussusception due to an inverted Meckel's diverticulum. ( 21752739 )
2012

Variations for Ileocolitis

Expression for Ileocolitis

Search GEO for disease gene expression data for Ileocolitis.

Pathways for Ileocolitis

GO Terms for Ileocolitis

Biological processes related to Ileocolitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.7 DLG5 MYO9B NOD2
2 inflammatory response GO:0006954 9.63 IL2RA NOD2 TNF
3 regulation of inflammatory response GO:0050727 9.51 NOD2 TNF
4 cellular response to organic cyclic compound GO:0071407 9.49 NOD2 TNF
5 positive regulation of JNK cascade GO:0046330 9.48 NOD2 TNF
6 positive regulation of MAP kinase activity GO:0043406 9.43 NOD2 TNF
7 JNK cascade GO:0007254 9.4 NOD2 TNF
8 positive regulation of interleukin-6 production GO:0032755 9.37 NOD2 TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.32 NOD2 TNF
10 negative regulation of T cell proliferation GO:0042130 9.26 DLG5 IL2RA
11 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.16 NOD2 TNF
12 negative regulation of immune response GO:0050777 8.96 IL2RA NOD2
13 positive regulation of interleukin-8 production GO:0032757 8.62 NOD2 TNF

Sources for Ileocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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