ILEUS
MCID: ILS001
MIFTS: 51

Ileus (ILEUS)

Categories: Gastrointestinal diseases

Aliases & Classifications for Ileus

MalaCards integrated aliases for Ileus:

Name: Ileus 12 44 15
Ileus of Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8440
MeSH 44 D045823
NCIt 50 C37979
SNOMED-CT 68 81060008
ICD10 33 K56.7
UMLS 72 C1258215

Summaries for Ileus

MalaCards based summary : Ileus, also known as ileus of intestine, is related to meconium ileus and paralytic ileus. An important gene associated with Ileus is GUCY2C (Guanylate Cyclase 2C), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Peppermint and Ranitidine have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 75 Ileus is a disruption of the normal propulsive ability of the intestine due to the malfunction of... more...

Related Diseases for Ileus

Diseases related to Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 633)
# Related Disease Score Top Affiliating Genes
1 meconium ileus 34.6 SLC6A14 SLC26A9 GUCY2C CFTR
2 paralytic ileus 33.6 CRP CCK
3 intussusception 31.9 IL6 CRP CFTR
4 peritonitis 30.9 IL6 IL1B CRP CCL2
5 cholangitis 30.8 IL6 CRP CFTR
6 appendicitis 30.8 IL6 IL1B CRP
7 endometriosis 30.5 IL6 IL1B CCL2
8 cystitis 30.3 IL6 CRP CCL2
9 gastroenteritis 30.2 IL6 IL1B CRP
10 secretory diarrhea 30.2 SST GUCY2C CFTR
11 pulmonary edema 30.1 IL1B CRP CFTR
12 perinatal necrotizing enterocolitis 30.1 IL6 IL1B CRP
13 pain agnosia 30.0 OPRM1 NTS CCK
14 cytomegalovirus infection 30.0 IL6 IL1B CCL2
15 diarrhea 30.0 SST GUCY2C CFTR CCK
16 acute cystitis 29.9 IL6 CRP CCL2
17 gastroparesis 29.9 GHSR GHRL CCK
18 lung disease 29.8 IL6 IL1B CFTR CCL2
19 pulmonary disease, chronic obstructive 29.8 IL6 CRP CFTR CCL2
20 intestinal disease 29.8 IL6 IL1B GHRL CRP
21 pancreatitis 29.7 SST CRP CFTR CCK
22 pheochromocytoma 29.6 VIP SST CRH CALCA
23 vipoma 29.5 VIP SST NTS
24 duodenal ulcer 29.5 SST IL1B CCK
25 dyspepsia 29.4 SST GHRL CCK
26 typhoid fever 29.3 IL6 IL1B CRP CFTR
27 pyelonephritis 29.3 IL6 IL1B CRP CCL2
28 meningitis 29.3 IL6 IL1B CRP CCL2
29 proteasome-associated autoinflammatory syndrome 1 29.3 IL6 IL1B CRP CCL2
30 pneumonia 29.3 IL6 IL1B CRP CCL2
31 steatorrhea 29.3 SST CFTR CCK
32 acute pancreatitis 29.3 SST IL6 CRP CFTR CCK
33 diabetes mellitus, noninsulin-dependent 29.1 SST IL6 GHRL CRP CCL2
34 anorexia nervosa 29.1 GHRL CRH CCK
35 short bowel syndrome 29.1 SST NTS CCK
36 bacterial infectious disease 29.0 IL6 IL1B CRP CFTR CCL2
37 diabetes mellitus 28.9 SST IL6 IL1B GHRL CRP
38 myocardial infarction 28.8 IL6 IL1B GHRL CRP CCL2
39 constipation 28.7 VIP SST OPRM1 NTS CCK CALCA
40 pertussis 28.7 VIP SST OPRM1 IL6 IL1B
41 gastroesophageal reflux 27.6 VIP NTS IL1B GHRL CCK
42 chronic duodenal ileus 12.4
43 cystic fibrosis, modifier of, 1 12.0
44 intestinal pseudo-obstruction 11.9
45 cystic fibrosis 11.8
46 ogilvie syndrome 11.5
47 intestinal volvulus 11.0
48 intestinal obstruction 10.9
49 gallbladder disease 1 10.6
50 cholelithiasis 10.6

Graphical network of the top 20 diseases related to Ileus:



Diseases related to Ileus

Symptoms & Phenotypes for Ileus

MGI Mouse Phenotypes related to Ileus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 CFTR CRH GHRL GHSR GUCY2C IL6
2 homeostasis/metabolism MP:0005376 10 CCK CFTR CRH CRP GHRL GHSR
3 adipose tissue MP:0005375 9.95 CRH GHRL GHSR GUCY2C IL6 NTS
4 digestive/alimentary MP:0005381 9.92 CFTR GHRL GHSR GUCY2C IL6 OPRM1
5 endocrine/exocrine gland MP:0005379 9.91 CCK CFTR CRH GHRL IL6 OPRM1
6 immune system MP:0005387 9.7 CCL2 CFTR CRH CRP GUCY2C IL1B
7 no phenotypic analysis MP:0003012 9.17 CCK CFTR CRH GHSR NTS OPRM1

Drugs & Therapeutics for Ileus

Drugs for Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 302)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Peppermint Approved Phase 4
2
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
3
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
4
Orphenadrine Approved Phase 4 83-98-7 4601
5
Histamine Approved, Investigational Phase 4 51-45-6 774
6
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
7
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
8
Succinylcholine Approved Phase 4 306-40-1 5314
9
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
10
Povidone-iodine Approved Phase 4 25655-41-8
11
Loperamide Approved Phase 4 53179-11-6 3955
12
Magnesium hydroxide Approved, Investigational Phase 4 1309-42-8
13
Bisacodyl Approved Phase 4 603-50-9
14
Bismuth subsalicylate Approved, Vet_approved Phase 4 14882-18-9 53629521
15
Simethicone Approved Phase 4 8050-81-5
16
Dimenhydrinate Approved Phase 4 523-87-5 441281
17
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
18
tannic acid Approved Phase 4 1401-55-4
19
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
20
Sorbitol Approved Phase 4 50-70-4 5780
21
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
22
Clonidine Approved Phase 4 4205-90-7 2803
23
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
24
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
25
Labetalol Approved Phase 4 36894-69-6 3869
26 Hydrotalcite Approved, Experimental, Investigational Phase 4 12304-65-3
27
Aluminum hydroxide Approved, Investigational Phase 4 21645-51-2
28
Sucralfate Approved Phase 4 54182-58-0
29
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
30
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
31
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
32
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
33
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
34
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
35
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
36
Remifentanil Approved Phase 4 132875-61-7 60815
37
Ondansetron Approved Phase 4 99614-02-5 4595
38
Scopolamine Approved, Investigational Phase 4 6533-68-2, 51-34-3 5184
39
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
40
Cyclobenzaprine Approved Phase 4 303-53-7 2895
41
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
42
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
43
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
44
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
45
Tapentadol Approved Phase 4 175591-23-8 9838022
46
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
47
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
48
Morphine Approved, Investigational Phase 4 57-27-2 5288826
49
Nicotine Approved Phase 4 54-11-5 942 89594
50
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570

Interventional clinical trials:

(show top 50) (show all 364)
# Name Status NCT ID Phase Drugs
1 Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus Unknown status NCT02425774 Phase 4 Prucalopride;Placebo
2 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4 gum
3 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Unknown status NCT02056405 Phase 4 Mosapride;Placebo
4 Effect of Intravenous Lidocaine on Postoperative Pain Management After Laparoscopy Cholecystectomy Unknown status NCT02997215 Phase 4 Lidocaine;Saline Placebo
5 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
6 Usefulness Of Flospan As A Premedication For Colonoscopy : A Randomized Double Blind Controlled Trial Unknown status NCT01842932 Phase 4 Phloroglucin;Cimetropium bromide;Placebo
7 Comparative Randomized Controlled Trial Study of General Balanced Anesthesia Based on Opioid and Opioid Sparing Balanced Anesthesia for Cholecystectomy Surgery Via Laparoscopy: Intraoperative and Postoperative Outcomes Unknown status NCT02953210 Phase 4 dexter ketamine;Lidocaine Hydrochloride;Fentanyl Hydrochloride;Clonidine Hydrochloride;Midazolam Hydrochloride;Isoflurane Volatile Liquid;Rocuronium Injectable Solution;Propofol 1 % Injectable Suspension;Dexamethasone-21-Sulfobenzoate, Sodium Salt;Ranitidine Hydrochloride;Ondansetron Hydrochloride;Ketorolac Injectable Solution;Bupivacaine Hydrochloride
8 NK Activity Modulation by Intravenous Lidocaine During Laparoscopic Colorectal Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
9 Randomised Study to Compare the Regain of Gastrointestinal Motility After General Anaesthesia Versus Spinal Anaesthesia in Caesarean Section.Kasr El Ainy,Egypt Experience Unknown status NCT02504749 Phase 4
10 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
11 COLITIS: Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
12 Prospective Randomized Double Blind Study of the Effect of Gastrografin on Postoperative Ileus After Colorectal Surgery Completed NCT01440712 Phase 4 Gastrografin;physiological serum
13 Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation Completed NCT01956643 Phase 4
14 A Phase 4, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Postoperative Ileus in Subjects Undergoing Radical Cystectomy. Completed NCT00708201 Phase 4 Alvimopan;Placebo
15 A New Approach of Neostigmine in Unavoidable Post Operative Ileus After Surgery Completed NCT00676377 Phase 4 Neostigmine;Saline
16 A Randomized Controlled Trial of the Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery: A Pilot Study Completed NCT02161367 Phase 4 Simethicone;Oral Suspending Vehicle
17 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4 Magnesia;Placebo
18 Preoperative Bowel Preparation Versus no Preparation Before Spinal Surgery: a Randomised Clinical Trial Completed NCT01879605 Phase 4 Docusate natrium and sorbitol;Bisacodyl
19 Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery Completed NCT00509327 Phase 4 bisacodyl;glucosemonohydricum
20 Influence of Epidural Analgesia in Elective Laparoscopic Colorectal Resections Completed NCT00512395 Phase 4 epidural analgesia (Duracain/Fentanyl/Naropin)
21 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants- a Phase 4 Study Completed NCT01515696 Phase 4 Gastrografin;Sterile water
22 Opioid Free Anesthesia: What About Patient Comfort? Completed NCT02882035 Phase 4
23 Postoperative Analgesic Effects of Dexmedetomidine Added to Bupivacaine for Transversus Abdominis Plane Block for Lower Abdominal Surgery Completed NCT02064530 Phase 4 Bupivacaine;Dexmedetomidine;serum physiologic
24 Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease: A Prospective Randomized Single-Blind Trial Completed NCT00453830 Phase 4
25 The Impact of Visceral Osteopathic Treatment on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT02140710 Phase 4
26 Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial Completed NCT02363699 Phase 4 Lidocaine;Saline solution
27 Laparoscope Subtotal Colectomy With Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation Completed NCT02147574 Phase 4
28 Surgical Pain Control With Ropivacaine by Atomized Delivery Completed NCT01480089 Phase 4 Intraperitoneal Ropivacaine (AIR);Atomized Intraperitoneal Saline (AIS)
29 A Randomized Clinical Study of the Efficacy of a Formulation of Four Probiotics for the Prevention of Post-operative Complications in Patients Undergoing Colorectal Surgery Completed NCT02313519 Phase 4
30 Estimation of the Effect of Intravenous Lidocaine on BIS-guided Propofol Requirements During General Anesthesia Completed NCT01366300 Phase 4 Intravenous lidocaine infusion;Propofol 1% (intravenous infusion)
31 Randomized, Double-Blinded, Active-Controlled Study to Evaluate the Intraoperative Use of Labetalol vs. Esmolol for Maintaining Hemodynamic Stability During Laparoscopic Surgery: Effect on Recovery and Postoperative Pain Completed NCT01114971 Phase 4 Fentanyl;Labetalol;Esmolol
32 Impact of the Serratus Plane Block in Pain and the Use of Opioids in Breast Completed NCT02905149 Phase 4
33 A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment: Randomized Trial Completed NCT03635372 Phase 4 Alginate;Sucralfate;Hydrotalcite
34 A Randomized Comparison of Concomitant Incontinence Procedures Performed With Abdominal Sacral Colpopexy: the Burch Versus Mid-urethral Sling Trial Completed NCT00934999 Phase 4
35 Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia: Randomized Clinical Trial Completed NCT01778387 Phase 4
36 A Simple Oral Nutrition Protocol Reduces Length of Stay in Patients With Regular Radical Cystectomy Completed NCT01777126 Phase 4
37 Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial Completed NCT00318825 Phase 4 Nitrous oxide
38 Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty Completed NCT02601651 Phase 4 Lidocaine;Normal saline
39 Assessing the Safety of a Continuous Potassium Chloride Infusion in Critical Care: A Randomised Controlled Trial Completed NCT00718068 Phase 4 Sterile Potassium Chloride Concentrate;Sterile Potassium Chloride Concentrate
40 Adjuvant Analgesic Effects of Low Dose Tramadol/Acetaminophen Combination After Open Gynaecological Surgery Completed NCT00942565 Phase 4 tramadol/acetaminophen;acetaminophen
41 PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation: A Randomised Controlled Study Completed NCT01788709 Phase 4
42 Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
43 A Double Blind, Randomized, Parallel Design Study to Evaluate the Effectiveness of Post-operative Dose of Alvimopan(Entereg) in Preventing Post-operative Ileus in Poly-traumatized Patients Recruiting NCT03068975 Phase 4 Alvimopan;Placebo
44 The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus Recruiting NCT03176316 Phase 4 Naloxone
45 A Prospective Randomized Trial of Transversus Abdominis Plane (TAP) INtraoperative Block With Bupivacaine/Dexamethasone aGainst Liposomal Bupivacaine (Exparel®): the TINGLE Trial Recruiting NCT03723447 Phase 4 Liposomal bupivacaine;Bupivacaine/epinephrine/dexamethasone
46 Efficacy of the Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures Recruiting NCT02805504 Phase 4 Exparel;Marcaine
47 Impact of the Administration of Intravenous or Paravertebral Lidocaine in Continuous Perfusion During the Intraoperative Period of Lung Resection Surgery on the Appearance of Postoperative Complications Recruiting NCT03905837 Phase 4 Lidocaine;Remifentanil
48 Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study Recruiting NCT02202369 Phase 4
49 A Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial Evaluating the Use of Perioperative Intravenous Lidocaine Infusion to Decrease Pain Scores and Opioid Consumption After Robotic-Assisted Prostatectomy and Robotic-Assisted Partial Nephrectomy Recruiting NCT03824808 Phase 4 Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution;0.9% Sodium Chloride Injection
50 The Use of Gastrografin to Help Alleviate Bowel Obstruction Related to Poor Bowel Motility in Gastroschisis Patients. Recruiting NCT03334578 Phase 4 Gastrografin

Search NIH Clinical Center for Ileus

Cochrane evidence based reviews: ileus

Genetic Tests for Ileus

Anatomical Context for Ileus

MalaCards organs/tissues related to Ileus:

41
Colon, Small Intestine, Liver, Lung, Kidney, Pancreas, Lymph Node

Publications for Ileus

Articles related to Ileus:

(show top 50) (show all 11175)
# Title Authors PMID Year
1
Perioperative complications associated with minimally invasive surgery of oblique lumbar interbody fusions for degenerative lumbar diseases in 113 patients. 38
31302382 2019
2
Homozygous Deletion of the CFTR Gene Caused by Interstitial Maternal Isodisomy in a Peruvian Child with Cystic Fibrosis. 38
31406621 2019
3
Isoperistaltic versus antiperistaltic ileocolic anastomosis. Does it really matter? Results from a randomised clinical trial (ISOVANTI). 38
30426254 2019
4
CT Scan Findings Can Predict the Safety of Delayed Appendectomy for Acute Appendicitis. 38
30225795 2019
5
Clinicopathological characteristics of diffuse large B-cell lymphoma involving small and large intestines: an analysis of 126 patients. 38
31187439 2019
6
Correction: CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus. 38
31391293 2019
7
The risk factors for postoperative ileus following posterior thoraco-lumbar spinal fusion surgery. 38
31310924 2019
8
Efficacy of Celiac Branch Preservation in Billroth-Ⅰ Reconstruction After Laparoscopy-Assisted Distal Gastrectomy. 38
31425872 2019
9
Immunomodulator-associated Epstein-Barr virus-positive mucocutaneous ulcer in a patient with refractory Crohn's disease. 38
30903514 2019
10
Is There Still a Place for Lidocaine in the (Postoperative) Management of Colics? 38
31076222 2019
11
Perioperative Outcomes and Predictors of Mortality After Surgery for Sigmoid Volvulus. 38
31415933 2019
12
Influence of preoperative enema application on the return of gastrointestinal function in elective Cesarean sections: a randomized controlled trial. 38
31397204 2019
13
Idarucizumab administration in emergency situations: the Munich Registry of Reversal of Pradaxa® in clinical routine (MR REPAIR). 38
31375990 2019
14
Electrical Stimulation and Recovery of Gastrointestinal Function Following Surgery: A Systematic Review. 38
30451336 2019
15
Use of perioperative variables to determine the requirement for repeat celiotomy in horses with postoperative reflux after small intestinal surgery. 38
31403222 2019
16
Successful patient orientated surgical outcomes in robotic versus laparoscopic right hemicolectomy for cancer - a systematic review. 38
31400185 2019
17
Two-year patient-related outcome measures (PROM) of primary ventral and incisional hernia repair using a novel three-dimensional composite polyester monofilament mesh: the SymCHro registry study. 38
30887379 2019
18
Outcomes of emergency abdominal surgery in octogenarians: A single-center analysis. 38
30509459 2019
19
Does Coffee Intake Reduce Postoperative Ileus After Laparoscopic Elective Colorectal Surgery? A Prospective, Randomized Controlled Study: The Coffee Study. 38
30998528 2019
20
Gastrointestinal Failure in Critically Ill Patients With Cirrhosis. 38
31185004 2019
21
A simple classification of peritoneal contamination in perforated appendicitis predicts surgery-related complications. 38
31410904 2019
22
CT in Differentiating Complicated From Uncomplicated Appendicitis: Presence of Any of 10 CT Features Versus Radiologists' Gestalt Assessment. 38
31414891 2019
23
Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. 38
31407849 2019
24
Robotic Versus Laparoscopic Sigmoid Resection for Diverticular Disease: A Single-Center Experience of 106 Cases. 38
31433257 2019
25
Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern. 38
31374154 2019
26
Pre-Operative, Intra-Operative, and Post-Operative Factors Associated with Post-Discharge Venous Thromboembolism Following Colorectal Cancer Resection. 38
31420856 2019
27
Mechanical small bowel obstruction due to appendiceal tourniquet: a case report and review of literature. 38
31391122 2019
28
Non-Cystic Fibrosis-Related Meconium Ileus: GUCY2C-Associated Disease Discovered through Rapid Neonatal Whole-Exome Sequencing. 38
31079856 2019
29
A Video Case Report of Gastric Perforation Following Endoscopic Sleeve Gastroplasty and its Surgical Treatment. 38
31376132 2019
30
Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System. 38
31412557 2019
31
Correction to: Postoperative ileus concealing intra-abdominal complications in enhanced recovery programs-a retrospective analysis of the GRACE database. 38
31286214 2019
32
Daikenchuto accelerates the recovery from prolonged postoperative ileus after open abdominal surgery: a subgroup analysis of three randomized controlled trials. 38
30805720 2019
33
Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons. 38
30472681 2019
34
Thresholds for optimal fluid administration and weight gain after laparoscopic colorectal surgery. 38
31388646 2019
35
Efficacy of intestinal obstruction stent combined with laparoscopic surgery and neoadjuvant chemotherapy in patients with obstructive colorectal cancer. 38
31423263 2019
36
Prolonged postoperative ileus in gastric surgery: Is there any difference between laparoscopic and open surgery? 38
31385451 2019
37
A Case of Small Intestinal Ileus Due to Wandering Spleen with a Large Cyst. 38
31371695 2019
38
Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis. 38
31020433 2019
39
Gallstone ileus with evident forchet sign:case report. 38
31382234 2019
40
Key Points for Cholelithiasis and Gallstone Ileus Prevention Following Biliointestinal Bypass. 38
31326973 2019
41
Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial. 38
31345626 2019
42
Risk factors for adverse outcome in infancy in meconium ileus cystic fibrosis infants: A multicentre Italian study. 38
31353045 2019
43
Correction of Spondylolisthesis by Lateral Lumbar Interbody Fusion Compared with Transforaminal Lumbar Interbody Fusion at L4-5. 38
31064044 2019
44
Analysis of Spino-Pelvic Parameters and Segmental Lordosis with L5-S1 Oblique Lateral Interbody Fusion at the Bottom of a Long Construct in Circumferential Minimally Invasive Surgical Correction of Adult Spinal Deformity. 38
31323412 2019
45
Avoiding the Need for Bowel Anastomosis during Pelvic Exenteration-Urinary Sigmoid or Descending Colon Conduit-Short and Long Term Complications. 38
30922975 2019
46
Epidural analgesia in the era of enhanced recovery: time to rethink its use? 38
30353240 2019
47
Endoscopic Nasoenteral Feeding Tube Fixation with Hemoclip Reduces Tube Dislodgement. 38
31367879 2019
48
Impact of pre-operative walking on post-operative bowel function in patients with gynecologic cancer. 38
31326951 2019
49
The effect of diets delivered into the gastrointestinal tract on gut motility after colorectal surgery-a systematic review and meta-analysis of randomised controlled trials. 38
31366995 2019
50
Validity of the I-FEED score for postoperative gastrointestinal function in patients undergoing colorectal surgery. 38
31363895 2019

Variations for Ileus

Expression for Ileus

Search GEO for disease gene expression data for Ileus.

Pathways for Ileus

Pathways related to Ileus according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 VIP SST OPRM1 NTS IL6 GHSR
2
Show member pathways
13.25 SST OPRM1 NTS GHSR GHRL CRH
3
Show member pathways
12.33 IL6 IL1B CRH CALCA
4
Show member pathways
12.09 IL6 IL1B CRP CCL2
5
Show member pathways
12.07 IL6 IL1B CFTR CCL2
6 11.83 IL6 IL1B CCL2
7 11.77 IL6 IL1B CCL2
8 11.7 IL6 IL1B CCL2
9 11.65 IL6 IL1B CCL2
10
Show member pathways
11.61 VIP IL6 CRP
11 11.5 IL6 IL1B CCL2
12 11.31 OPRM1 IL6 IL1B CCL2
13 11.19 IL6 IL1B CCL2
14 11.12 IL6 IL1B CCL2
15 10.99 IL6 IL1B CALCA
16 10.77 IL1B CCL2
17 10.72 IL6 IL1B CCL2 CALCA
18 10.25 VIP CCK

GO Terms for Ileus

Cellular components related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SST IL6 IL1B GHRL CRP CRH
2 perikaryon GO:0043204 9.46 VIP OPRM1 CRH CCK
3 extracellular region GO:0005576 9.36 VIP SST NTS IL6 IL1B GHRL

Biological processes related to Ileus according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 SLC26A9 IL6 IL1B CRP CRH
2 cytokine-mediated signaling pathway GO:0019221 9.98 OPRM1 IL6 IL1B CCL2
3 cellular response to lipopolysaccharide GO:0071222 9.84 IL6 IL1B GHSR CCL2
4 learning or memory GO:0007611 9.79 VIP GHSR CRH
5 monocyte chemotaxis GO:0002548 9.7 IL6 CCL2 CALCA
6 regulation of NMDA receptor activity GO:2000310 9.69 OPRM1 CRH
7 response to ethanol GO:0045471 9.69 OPRM1 CRH
8 positive regulation of glial cell proliferation GO:0060252 9.68 IL6 IL1B
9 positive regulation of calcium ion import GO:0090280 9.68 CRH CCL2
10 negative regulation of bone resorption GO:0045779 9.68 IL6 CALCA
11 actin polymerization or depolymerization GO:0008154 9.67 GHSR GHRL
12 positive regulation of growth GO:0045927 9.67 GHSR GHRL
13 negative regulation of interleukin-1 beta production GO:0032691 9.66 GHSR GHRL
14 adult feeding behavior GO:0008343 9.65 GHSR GHRL
15 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.65 GHSR GHRL
16 negative regulation of lipid storage GO:0010888 9.65 IL6 CRP
17 negative regulation of appetite GO:0032099 9.64 GHSR CCK
18 negative regulation of tumor necrosis factor secretion GO:1904468 9.64 GHSR GHRL
19 negative regulation of norepinephrine secretion GO:0010700 9.63 GHSR CRH
20 growth hormone secretion GO:0030252 9.62 GHSR GHRL
21 positive regulation of neuroinflammatory response GO:0150078 9.61 IL6 IL1B
22 positive regulation of behavioral fear response GO:2000987 9.61 CRH CCK
23 regulation of sensory perception of pain GO:0051930 9.61 VIP OPRM1 CCK
24 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.6 GHSR GHRL
25 positive regulation of cortisol secretion GO:0051464 9.58 GHRL CRH
26 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.58 GHRL CRH CFTR
27 positive regulation of corticotropin secretion GO:0051461 9.57 GHRL CRH
28 negative regulation of interleukin-6 biosynthetic process GO:0045409 9.56 GHSR GHRL
29 hormone-mediated apoptotic signaling pathway GO:0008628 9.55 SST CRH
30 inflammatory response GO:0006954 9.55 IL6 IL1B CRP CRH CCL2
31 digestion GO:0007586 9.54 SST GUCY2C CCK
32 regulation of transmission of nerve impulse GO:0051969 9.51 GHSR GHRL
33 positive regulation of eating behavior GO:1904000 9.49 GHSR GHRL
34 regulation of gastric motility GO:1905333 9.48 GHSR GHRL
35 positive regulation of small intestine smooth muscle contraction GO:1904349 9.46 GHSR GHRL
36 response to dexamethasone GO:0071548 9.37 GHSR
37 positive regulation of small intestinal transit GO:0120058 9.32 GHSR GHRL
38 G protein-coupled receptor signaling pathway GO:0007186 9.32 VIP SST OPRM1 NTS GHSR GHRL
39 response to heat GO:0009408 9.28 SST
40 negative regulation of circadian sleep/wake cycle, REM sleep GO:0042322 9.26 GHRL CRH
41 positive regulation of appetite GO:0032100 9.13 OPRM1 GHSR GHRL
42 signal transduction GO:0007165 10.23 OPRM1 NTS IL1B GUCY2C GHSR CRH
43 positive regulation of cell proliferation GO:0008284 10.06 VIP IL6 IL1B CRH CCK

Molecular functions related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride transmembrane transporter activity GO:0015108 9.32 SLC26A9 CFTR
2 bicarbonate transmembrane transporter activity GO:0015106 9.26 SLC26A9 CFTR
3 neuropeptide hormone activity GO:0005184 9.26 VIP NTS CRH CCK
4 peptide hormone receptor binding GO:0051428 9.16 VIP CCK
5 hormone activity GO:0005179 9.1 VIP SST GHRL CRH CCK CALCA

Sources for Ileus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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