Ileus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

ILEUS MCID: ILS001 MIFTS: 51	Ileus (ILEUS) Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Ileus

MalaCards integrated aliases for Ileus:

Name: Ileus ¹² ⁴⁴ ¹⁵

Ileus of Intestine ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Other diseases of intestines

Paralytic ileus and intestinal obstruction without hernia

Ileus, unspecified

External Ids:

Disease Ontology ¹² DOID:8440

MeSH ⁴⁴ D045823

NCIt ⁵⁰ C37979

SNOMED-CT ⁶⁸ 81060008

ICD10 ³³ K56.7

UMLS ⁷² C1258215

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Summaries for Ileus

MalaCards based summary : Ileus, also known as ileus of intestine, is related to meconium ileus and paralytic ileus. An important gene associated with Ileus is GUCY2C (Guanylate Cyclase 2C), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Peppermint and Ranitidine have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : ⁷⁵ Ileus is a disruption of the normal propulsive ability of the intestine due to the malfunction of... more...

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Related Diseases for Ileus

Diseases related to Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 633)

#	Related Disease	Score	Top Affiliating Genes
1	meconium ileus	34.6	SLC6A14 SLC26A9 GUCY2C CFTR
2	paralytic ileus	33.6	CRP CCK
3	intussusception	31.9	IL6 CRP CFTR
4	peritonitis	30.9	IL6 IL1B CRP CCL2
5	cholangitis	30.8	IL6 CRP CFTR
6	appendicitis	30.8	IL6 IL1B CRP
7	endometriosis	30.5	IL6 IL1B CCL2
8	cystitis	30.3	IL6 CRP CCL2
9	gastroenteritis	30.2	IL6 IL1B CRP
10	secretory diarrhea	30.2	SST GUCY2C CFTR
11	pulmonary edema	30.1	IL1B CRP CFTR
12	perinatal necrotizing enterocolitis	30.1	IL6 IL1B CRP
13	pain agnosia	30.0	OPRM1 NTS CCK
14	cytomegalovirus infection	30.0	IL6 IL1B CCL2
15	diarrhea	30.0	SST GUCY2C CFTR CCK
16	acute cystitis	29.9	IL6 CRP CCL2
17	gastroparesis	29.9	GHSR GHRL CCK
18	lung disease	29.8	IL6 IL1B CFTR CCL2
19	pulmonary disease, chronic obstructive	29.8	IL6 CRP CFTR CCL2
20	intestinal disease	29.8	IL6 IL1B GHRL CRP
21	pancreatitis	29.7	SST CRP CFTR CCK
22	pheochromocytoma	29.6	VIP SST CRH CALCA
23	vipoma	29.5	VIP SST NTS
24	duodenal ulcer	29.5	SST IL1B CCK
25	dyspepsia	29.4	SST GHRL CCK
26	typhoid fever	29.3	IL6 IL1B CRP CFTR
27	pyelonephritis	29.3	IL6 IL1B CRP CCL2
28	meningitis	29.3	IL6 IL1B CRP CCL2
29	proteasome-associated autoinflammatory syndrome 1	29.3	IL6 IL1B CRP CCL2
30	pneumonia	29.3	IL6 IL1B CRP CCL2
31	steatorrhea	29.3	SST CFTR CCK
32	acute pancreatitis	29.3	SST IL6 CRP CFTR CCK
33	diabetes mellitus, noninsulin-dependent	29.1	SST IL6 GHRL CRP CCL2
34	anorexia nervosa	29.1	GHRL CRH CCK
35	short bowel syndrome	29.1	SST NTS CCK
36	bacterial infectious disease	29.0	IL6 IL1B CRP CFTR CCL2
37	diabetes mellitus	28.9	SST IL6 IL1B GHRL CRP
38	myocardial infarction	28.8	IL6 IL1B GHRL CRP CCL2
39	constipation	28.7	VIP SST OPRM1 NTS CCK CALCA
40	pertussis	28.7	VIP SST OPRM1 IL6 IL1B
41	gastroesophageal reflux	27.6	VIP NTS IL1B GHRL CCK
42	chronic duodenal ileus	12.4
43	cystic fibrosis, modifier of, 1	12.0
44	intestinal pseudo-obstruction	11.9
45	cystic fibrosis	11.8
46	ogilvie syndrome	11.5
47	intestinal volvulus	11.0
48	intestinal obstruction	10.9
49	gallbladder disease 1	10.6
50	cholelithiasis	10.6

Graphical network of the top 20 diseases related to Ileus:

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Symptoms & Phenotypes for Ileus

MGI Mouse Phenotypes related to Ileus:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.07	CFTR CRH GHRL GHSR GUCY2C IL6
2	homeostasis/metabolism	MP:0005376	10	CCK CFTR CRH CRP GHRL GHSR
3	adipose tissue	MP:0005375	9.95	CRH GHRL GHSR GUCY2C IL6 NTS
4	digestive/alimentary	MP:0005381	9.92	CFTR GHRL GHSR GUCY2C IL6 OPRM1
5	endocrine/exocrine gland	MP:0005379	9.91	CCK CFTR CRH GHRL IL6 OPRM1
6	immune system	MP:0005387	9.7	CCL2 CFTR CRH CRP GUCY2C IL1B
7	no phenotypic analysis	MP:0003012	9.17	CCK CFTR CRH GHSR NTS OPRM1

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Drugs & Therapeutics for Ileus

Drugs for Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 302)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Peppermint

Approved

Phase 4

Ranitidine

Approved

Phase 4

66357-35-5, 66357-59-3

3001055

Atracurium

Approved, Experimental, Investigational

Phase 4

64228-79-1

47319

Orphenadrine

Approved

Phase 4

83-98-7

4601

Histamine

Approved, Investigational

Phase 4

51-45-6

774

Isoflurane

Approved, Vet_approved

Phase 4

26675-46-7

3763

Rocuronium

Approved

Phase 4

119302-91-9, 143558-00-3

441290

Succinylcholine

Approved

Phase 4

306-40-1

5314

Thiopental

Approved, Vet_approved

Phase 4

76-75-5

3000715

Povidone-iodine

Approved

Phase 4

25655-41-8

Loperamide

Approved

Phase 4

53179-11-6

3955

Magnesium hydroxide

Approved, Investigational

Phase 4

1309-42-8

Bisacodyl

Approved

Phase 4

603-50-9

Bismuth subsalicylate

Approved, Vet_approved

Phase 4

14882-18-9

53629521

Simethicone

Approved

Phase 4

8050-81-5

Dimenhydrinate

Approved

Phase 4

523-87-5

441281

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

tannic acid

Approved

Phase 4

1401-55-4

Benzocaine

Approved, Investigational

Phase 4

94-09-7, 1994-09-7

2337

Sorbitol

Approved

Phase 4

50-70-4

5780

Diclofenac

Approved, Vet_approved

Phase 4

15307-86-5

3033

Clonidine

Approved

Phase 4

4205-90-7

2803

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Labetalol

Approved

Phase 4

36894-69-6

3869

Hydrotalcite

Approved, Experimental, Investigational

Phase 4

12304-65-3

Aluminum hydroxide

Approved, Investigational

Phase 4

21645-51-2

Sucralfate

Approved

Phase 4

54182-58-0

Nitrous oxide

Approved, Vet_approved

Phase 4

10024-97-2

948

Naloxone

Approved, Vet_approved

Phase 4

465-65-6

5284596

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Remifentanil

Approved

Phase 4

132875-61-7

60815

Ondansetron

Approved

Phase 4

99614-02-5

4595

Scopolamine

Approved, Investigational

Phase 4

6533-68-2, 51-34-3

5184

Pregabalin

Approved, Illicit, Investigational

Phase 4

148553-50-8

5486971

Cyclobenzaprine

Approved

Phase 4

303-53-7

2895

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Hydrocodone

Approved, Illicit, Investigational

Phase 4

125-29-1

5284569

Tapentadol

Approved

Phase 4

175591-23-8

9838022

Neostigmine

Approved, Vet_approved

Phase 4

59-99-4

4456

Acetylcholine

Approved, Investigational

Phase 4

51-84-3

187

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Nicotine

Approved

Phase 4

54-11-5

942 89594

Hydromorphone

Approved, Illicit

Phase 4

466-99-9

5284570

Interventional clinical trials:

(show top 50) (show all 364)

#	Name	Status	NCT ID	Phase	Drugs
1	Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus	Unknown status	NCT02425774	Phase 4	Prucalopride;Placebo
2	Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies	Unknown status	NCT01835119	Phase 4	gum
3	Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery	Unknown status	NCT02056405	Phase 4	Mosapride;Placebo
4	Effect of Intravenous Lidocaine on Postoperative Pain Management After Laparoscopy Cholecystectomy	Unknown status	NCT02997215	Phase 4	Lidocaine;Saline Placebo
5	Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial.	Unknown status	NCT02958566	Phase 4	Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
6	Usefulness Of Flospan As A Premedication For Colonoscopy : A Randomized Double Blind Controlled Trial	Unknown status	NCT01842932	Phase 4	Phloroglucin;Cimetropium bromide;Placebo
7	Comparative Randomized Controlled Trial Study of General Balanced Anesthesia Based on Opioid and Opioid Sparing Balanced Anesthesia for Cholecystectomy Surgery Via Laparoscopy: Intraoperative and Postoperative Outcomes	Unknown status	NCT02953210	Phase 4	dexter ketamine;Lidocaine Hydrochloride;Fentanyl Hydrochloride;Clonidine Hydrochloride;Midazolam Hydrochloride;Isoflurane Volatile Liquid;Rocuronium Injectable Solution;Propofol 1 % Injectable Suspension;Dexamethasone-21-Sulfobenzoate, Sodium Salt;Ranitidine Hydrochloride;Ondansetron Hydrochloride;Ketorolac Injectable Solution;Bupivacaine Hydrochloride
8	NK Activity Modulation by Intravenous Lidocaine During Laparoscopic Colorectal Surgery	Unknown status	NCT01841294	Phase 4	Intravenous Lidocaine;Normal saline infusion
9	Randomised Study to Compare the Regain of Gastrointestinal Motility After General Anaesthesia Versus Spinal Anaesthesia in Caesarean Section.Kasr El Ainy,Egypt Experience	Unknown status	NCT02504749	Phase 4
10	Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial	Unknown status	NCT00625534	Phase 4
11	COLITIS: Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe	Unknown status	NCT01630096	Phase 4	Nu-Lytely
12	Prospective Randomized Double Blind Study of the Effect of Gastrografin on Postoperative Ileus After Colorectal Surgery	Completed	NCT01440712	Phase 4	Gastrografin;physiological serum
13	Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation	Completed	NCT01956643	Phase 4
14	A Phase 4, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Postoperative Ileus in Subjects Undergoing Radical Cystectomy.	Completed	NCT00708201	Phase 4	Alvimopan;Placebo
15	A New Approach of Neostigmine in Unavoidable Post Operative Ileus After Surgery	Completed	NCT00676377	Phase 4	Neostigmine;Saline
16	A Randomized Controlled Trial of the Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery: A Pilot Study	Completed	NCT02161367	Phase 4	Simethicone;Oral Suspending Vehicle
17	Effect of Postoperative Laxative on Bowel Function After Colonic Surgery	Completed	NCT00427492	Phase 4	Magnesia;Placebo
18	Preoperative Bowel Preparation Versus no Preparation Before Spinal Surgery: a Randomised Clinical Trial	Completed	NCT01879605	Phase 4	Docusate natrium and sorbitol;Bisacodyl
19	Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery	Completed	NCT00509327	Phase 4	bisacodyl;glucosemonohydricum
20	Influence of Epidural Analgesia in Elective Laparoscopic Colorectal Resections	Completed	NCT00512395	Phase 4	epidural analgesia (Duracain/Fentanyl/Naropin)
21	Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants- a Phase 4 Study	Completed	NCT01515696	Phase 4	Gastrografin;Sterile water
22	Opioid Free Anesthesia: What About Patient Comfort?	Completed	NCT02882035	Phase 4
23	Postoperative Analgesic Effects of Dexmedetomidine Added to Bupivacaine for Transversus Abdominis Plane Block for Lower Abdominal Surgery	Completed	NCT02064530	Phase 4	Bupivacaine;Dexmedetomidine;serum physiologic
24	Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease: A Prospective Randomized Single-Blind Trial	Completed	NCT00453830	Phase 4
25	The Impact of Visceral Osteopathic Treatment on the Meconium Evacuation in Very Low Birth Weight Infants	Completed	NCT02140710	Phase 4
26	Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial	Completed	NCT02363699	Phase 4	Lidocaine;Saline solution
27	Laparoscope Subtotal Colectomy With Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation	Completed	NCT02147574	Phase 4
28	Surgical Pain Control With Ropivacaine by Atomized Delivery	Completed	NCT01480089	Phase 4	Intraperitoneal Ropivacaine (AIR);Atomized Intraperitoneal Saline (AIS)
29	A Randomized Clinical Study of the Efficacy of a Formulation of Four Probiotics for the Prevention of Post-operative Complications in Patients Undergoing Colorectal Surgery	Completed	NCT02313519	Phase 4
30	Estimation of the Effect of Intravenous Lidocaine on BIS-guided Propofol Requirements During General Anesthesia	Completed	NCT01366300	Phase 4	Intravenous lidocaine infusion;Propofol 1% (intravenous infusion)
31	Randomized, Double-Blinded, Active-Controlled Study to Evaluate the Intraoperative Use of Labetalol vs. Esmolol for Maintaining Hemodynamic Stability During Laparoscopic Surgery: Effect on Recovery and Postoperative Pain	Completed	NCT01114971	Phase 4	Fentanyl;Labetalol;Esmolol
32	Impact of the Serratus Plane Block in Pain and the Use of Opioids in Breast	Completed	NCT02905149	Phase 4
33	A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment: Randomized Trial	Completed	NCT03635372	Phase 4	Alginate;Sucralfate;Hydrotalcite
34	A Randomized Comparison of Concomitant Incontinence Procedures Performed With Abdominal Sacral Colpopexy: the Burch Versus Mid-urethral Sling Trial	Completed	NCT00934999	Phase 4
35	Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia: Randomized Clinical Trial	Completed	NCT01778387	Phase 4
36	A Simple Oral Nutrition Protocol Reduces Length of Stay in Patients With Regular Radical Cystectomy	Completed	NCT01777126	Phase 4
37	Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial	Completed	NCT00318825	Phase 4	Nitrous oxide
38	Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty	Completed	NCT02601651	Phase 4	Lidocaine;Normal saline
39	Assessing the Safety of a Continuous Potassium Chloride Infusion in Critical Care: A Randomised Controlled Trial	Completed	NCT00718068	Phase 4	Sterile Potassium Chloride Concentrate;Sterile Potassium Chloride Concentrate
40	Adjuvant Analgesic Effects of Low Dose Tramadol/Acetaminophen Combination After Open Gynaecological Surgery	Completed	NCT00942565	Phase 4	tramadol/acetaminophen;acetaminophen
41	PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation: A Randomised Controlled Study	Completed	NCT01788709	Phase 4
42	Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain	Completed	NCT01096927	Phase 4	Amoxicillin and Clavulanic Acid
43	A Double Blind, Randomized, Parallel Design Study to Evaluate the Effectiveness of Post-operative Dose of Alvimopan(Entereg) in Preventing Post-operative Ileus in Poly-traumatized Patients	Recruiting	NCT03068975	Phase 4	Alvimopan;Placebo
44	The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus	Recruiting	NCT03176316	Phase 4	Naloxone
45	A Prospective Randomized Trial of Transversus Abdominis Plane (TAP) INtraoperative Block With Bupivacaine/Dexamethasone aGainst Liposomal Bupivacaine (Exparel®): the TINGLE Trial	Recruiting	NCT03723447	Phase 4	Liposomal bupivacaine;Bupivacaine/epinephrine/dexamethasone
46	Efficacy of the Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures	Recruiting	NCT02805504	Phase 4	Exparel;Marcaine
47	Impact of the Administration of Intravenous or Paravertebral Lidocaine in Continuous Perfusion During the Intraoperative Period of Lung Resection Surgery on the Appearance of Postoperative Complications	Recruiting	NCT03905837	Phase 4	Lidocaine;Remifentanil
48	Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study	Recruiting	NCT02202369	Phase 4
49	A Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial Evaluating the Use of Perioperative Intravenous Lidocaine Infusion to Decrease Pain Scores and Opioid Consumption After Robotic-Assisted Prostatectomy and Robotic-Assisted Partial Nephrectomy	Recruiting	NCT03824808	Phase 4	Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution;0.9% Sodium Chloride Injection
50	The Use of Gastrografin to Help Alleviate Bowel Obstruction Related to Poor Bowel Motility in Gastroschisis Patients.	Recruiting	NCT03334578	Phase 4	Gastrografin

Search NIH Clinical Center for Ileus

Cochrane evidence based reviews: ileus

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Genetic Tests for Ileus

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Anatomical Context for Ileus

MalaCards organs/tissues related to Ileus:

⁴¹

Colon, Small Intestine, Liver, Lung, Kidney, Pancreas, Lymph Node

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Publications for Ileus

Articles related to Ileus:

(show top 50) (show all 11175)

#	Title	Authors	PMID	Year
1	Perioperative complications associated with minimally invasive surgery of oblique lumbar interbody fusions for degenerative lumbar diseases in 113 patients. ³⁸	Liu C...Zhou Y	31302382	2019
2	Homozygous Deletion of the CFTR Gene Caused by Interstitial Maternal Isodisomy in a Peruvian Child with Cystic Fibrosis. ³⁸	Vasquez Sotomayor F...Abarca-Barriga HH	31406621	2019
3	Isoperistaltic versus antiperistaltic ileocolic anastomosis. Does it really matter? Results from a randomised clinical trial (ISOVANTI). ³⁸	Ibanez N...Parrilla P	30426254	2019
4	CT Scan Findings Can Predict the Safety of Delayed Appendectomy for Acute Appendicitis. ³⁸	Jeon BG...Heo SC	30225795	2019
5	Clinicopathological characteristics of diffuse large B-cell lymphoma involving small and large intestines: an analysis of 126 patients. ³⁸	Maeshima AM...Izutsu K	31187439	2019
6	Correction: CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus. ³⁸		31391293	2019
7	The risk factors for postoperative ileus following posterior thoraco-lumbar spinal fusion surgery. ³⁸	Deng WW...Liu JM	31310924	2019
8	Efficacy of Celiac Branch Preservation in Billroth-Ⅰ Reconstruction After Laparoscopy-Assisted Distal Gastrectomy. ³⁸	Liu Y...Hu X	31425872	2019
9	Immunomodulator-associated Epstein-Barr virus-positive mucocutaneous ulcer in a patient with refractory Crohn's disease. ³⁸	Hamanaka S...Kato N	30903514	2019
10	Is There Still a Place for Lidocaine in the (Postoperative) Management of Colics? ³⁸	Freeman DE	31076222	2019
11	Perioperative Outcomes and Predictors of Mortality After Surgery for Sigmoid Volvulus. ³⁸	Easterday A...Krishnamurty DM	31415933	2019
12	Influence of preoperative enema application on the return of gastrointestinal function in elective Cesarean sections: a randomized controlled trial. ³⁸	Ertas IE...Kurt S	31397204	2019
13	Idarucizumab administration in emergency situations: the Munich Registry of Reversal of Pradaxa® in clinical routine (MR REPAIR). ³⁸	Kupper C...Kellert L	31375990	2019
14	Electrical Stimulation and Recovery of Gastrointestinal Function Following Surgery: A Systematic Review. ³⁸	Penfold JA...O'Grady G	30451336	2019
15	Use of perioperative variables to determine the requirement for repeat celiotomy in horses with postoperative reflux after small intestinal surgery. ³⁸	Jacobs CC...Southwood LL	31403222	2019
16	Successful patient orientated surgical outcomes in robotic versus laparoscopic right hemicolectomy for cancer - a systematic review. ³⁸	Waters PS...Stevenson ARL	31400185	2019
17	Two-year patient-related outcome measures (PROM) of primary ventral and incisional hernia repair using a novel three-dimensional composite polyester monofilament mesh: the SymCHro registry study. ³⁸	Gillion JF...French Club Hernie Study Group	30887379	2019
18	Outcomes of emergency abdominal surgery in octogenarians: A single-center analysis. ³⁸	Lavanchy JL...Schnuriger B	30509459	2019
19	Does Coffee Intake Reduce Postoperative Ileus After Laparoscopic Elective Colorectal Surgery? A Prospective, Randomized Controlled Study: The Coffee Study. ³⁸	Hasler-Gehrer S...Nocito A	30998528	2019
20	Gastrointestinal Failure in Critically Ill Patients With Cirrhosis. ³⁸	Alukal JJ...Thuluvath PJ	31185004	2019
21	A simple classification of peritoneal contamination in perforated appendicitis predicts surgery-related complications. ³⁸	Wee JJ...Nah SA	31410904	2019
22	CT in Differentiating Complicated From Uncomplicated Appendicitis: Presence of Any of 10 CT Features Versus Radiologists' Gestalt Assessment. ³⁸	Kim HY...Lee KH	31414891	2019
23	Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. ³⁸	Petersen PC...Hong JC	31407849	2019
24	Robotic Versus Laparoscopic Sigmoid Resection for Diverticular Disease: A Single-Center Experience of 106 Cases. ³⁸	Beltzer C...Schmidt R	31433257	2019
25	Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern. ³⁸	Kubota K...Shimada M	31374154	2019
26	Pre-Operative, Intra-Operative, and Post-Operative Factors Associated with Post-Discharge Venous Thromboembolism Following Colorectal Cancer Resection. ³⁸	Schlick CJR...Merkow RP	31420856	2019
27	Mechanical small bowel obstruction due to appendiceal tourniquet: a case report and review of literature. ³⁸	Ahmed KA...Elkeleny MR	31391122	2019
28	Non-Cystic Fibrosis-Related Meconium Ileus: GUCY2C-Associated Disease Discovered through Rapid Neonatal Whole-Exome Sequencing. ³⁸	Woods JD...Graham JM	31079856	2019
29	A Video Case Report of Gastric Perforation Following Endoscopic Sleeve Gastroplasty and its Surgical Treatment. ³⁸	Surve A...Belnap L	31376132	2019
30	Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System. ³⁸	Norsa L...Colombo C	31412557	2019
31	Correction to: Postoperative ileus concealing intra-abdominal complications in enhanced recovery programs-a retrospective analysis of the GRACE database. ³⁸	Venara A...Francophone Group for Enhanced Recovery After Surgery (GRACE)	31286214	2019
32	Daikenchuto accelerates the recovery from prolonged postoperative ileus after open abdominal surgery: a subgroup analysis of three randomized controlled trials. ³⁸	Kono T...Kitajima M	30805720	2019
33	Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons. ³⁸	Stakenborg N...Boeckxstaens GE	30472681	2019
34	Thresholds for optimal fluid administration and weight gain after laparoscopic colorectal surgery. ³⁸	Hubner M...Grass F	31388646	2019
35	Efficacy of intestinal obstruction stent combined with laparoscopic surgery and neoadjuvant chemotherapy in patients with obstructive colorectal cancer. ³⁸	Yang L...Zhou S	31423263	2019
36	Prolonged postoperative ileus in gastric surgery: Is there any difference between laparoscopic and open surgery? ³⁸	Liang W...Chen L	31385451	2019
37	A Case of Small Intestinal Ileus Due to Wandering Spleen with a Large Cyst. ³⁸	Matsuyama T...Ushigome H	31371695	2019
38	Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis. ³⁸	Garfinkle R...Filion KB	31020433	2019
39	Gallstone ileus with evident forchet sign:case report. ³⁸	Ozer N	31382234	2019
40	Key Points for Cholelithiasis and Gallstone Ileus Prevention Following Biliointestinal Bypass. ³⁸	Micheletto G...Pontiroli AE	31326973	2019
41	Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial. ³⁸	de Boer SM...PORTEC Study Group	31345626	2019
42	Risk factors for adverse outcome in infancy in meconium ileus cystic fibrosis infants: A multicentre Italian study. ³⁸	Padoan R...Meconium Ileus Project Study Group	31353045	2019
43	Correction of Spondylolisthesis by Lateral Lumbar Interbody Fusion Compared with Transforaminal Lumbar Interbody Fusion at L4-5. ³⁸	Ko MJ...Kim YB	31064044	2019
44	Analysis of Spino-Pelvic Parameters and Segmental Lordosis with L5-S1 Oblique Lateral Interbody Fusion at the Bottom of a Long Construct in Circumferential Minimally Invasive Surgical Correction of Adult Spinal Deformity. ³⁸	Anand N...Khandehroo B	31323412	2019
45	Avoiding the Need for Bowel Anastomosis during Pelvic Exenteration-Urinary Sigmoid or Descending Colon Conduit-Short and Long Term Complications. ³⁸	Alemozaffar M...Master VA	30922975	2019
46	Epidural analgesia in the era of enhanced recovery: time to rethink its use? ³⁸	Al-Mazrou AM...Kiran RP	30353240	2019
47	Endoscopic Nasoenteral Feeding Tube Fixation with Hemoclip Reduces Tube Dislodgement. ³⁸	Han J...Jung HY	31367879	2019
48	Impact of pre-operative walking on post-operative bowel function in patients with gynecologic cancer. ³⁸	Ozdemir IA...Gungorduk K	31326951	2019
49	The effect of diets delivered into the gastrointestinal tract on gut motility after colorectal surgery-a systematic review and meta-analysis of randomised controlled trials. ³⁸	Hogan S...Carey S	31366995	2019
50	Validity of the I-FEED score for postoperative gastrointestinal function in patients undergoing colorectal surgery. ³⁸	Alsharqawi N...Lee L	31363895	2019

Sources

Genes for Ileus

Genes related to Ileus (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GUCY2C	Guanylate Cyclase 2C	Protein Coding	49.9	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
2	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	23.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	OPRM1	Opioid Receptor Mu 1	Protein Coding	22.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	22.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	GHSR	Growth Hormone Secretagogue Receptor	Protein Coding	22.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	SLC26A9	Solute Carrier Family 26 Member 9	Protein Coding	22.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL6	Interleukin 6	Protein Coding	21.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	SLC6A14	Solute Carrier Family 6 Member 14	Protein Coding	21.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	SST	Somatostatin	Protein Coding	21.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	CRP	C-Reactive Protein	Protein Coding	21.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IL1B	Interleukin 1 Beta	Protein Coding	21.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	21.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CRH	Corticotropin Releasing Hormone	Protein Coding	21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	NTS	Neurotensin	Protein Coding	20.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	CCK	Cholecystokinin	Protein Coding	20.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	VIP	Vasoactive Intestinal Peptide	Protein Coding	20.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	20.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Ileus

Sources

Expression for Ileus

Search GEO for disease gene expression data for Ileus.

Sources

Pathways for Ileus

Pathways related to Ileus according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	13.99	VIP SST OPRM1 NTS IL6 GHSR
2	Peptide ligand-binding receptors ⁶⁶ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁶ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁶ G alpha (i) signalling events ⁶⁶ GPCR ligand binding ⁶⁶ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁷ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁶ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁶ Vasopressin-like receptors ⁶⁶	13.25	SST OPRM1 NTS GHSR GHRL CRH
3	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	12.33	IL6 IL1B CRH CALCA
4	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.09	IL6 IL1B CRP CCL2
5	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.07	IL6 IL1B CFTR CCL2
6	Spinal Cord Injury ¹	11.83	IL6 IL1B CCL2
7	TNF signaling pathway ³⁷	11.77	IL6 IL1B CCL2
8	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.7	IL6 IL1B CCL2
9	Rheumatoid arthritis ³⁷	11.65	IL6 IL1B CCL2
10	IL-6 signaling pathway ¹ Show member pathways IL6-mediated signaling events ¹	11.61	VIP IL6 CRP
11	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.5	IL6 IL1B CCL2
12	Interleukin-4 and 13 signaling ⁶⁶	11.31	OPRM1 IL6 IL1B CCL2
13	Malaria ³⁷	11.19	IL6 IL1B CCL2
14	Interleukin-10 signaling ⁶⁶	11.12	IL6 IL1B CCL2
15	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.99	IL6 IL1B CALCA
16	LDL Oxidation in Atherogenesis ⁶⁴	10.77	IL1B CCL2
17	Lung fibrosis ¹	10.72	IL6 IL1B CCL2 CALCA
18	Gastric acid production ¹	10.25	VIP CCK

Sources

GO Terms for Ileus

Cellular components related to Ileus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.61	SST IL6 IL1B GHRL CRP CRH
2	perikaryon	GO:0043204	9.46	VIP OPRM1 CRH CCK
3	extracellular region	GO:0005576	9.36	VIP SST NTS IL6 IL1B GHRL

Biological processes related to Ileus according to GeneCards Suite gene sharing:

(show all 43)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.99	SLC26A9 IL6 IL1B CRP CRH
2	cytokine-mediated signaling pathway	GO:0019221	9.98	OPRM1 IL6 IL1B CCL2
3	cellular response to lipopolysaccharide	GO:0071222	9.84	IL6 IL1B GHSR CCL2
4	learning or memory	GO:0007611	9.79	VIP GHSR CRH
5	monocyte chemotaxis	GO:0002548	9.7	IL6 CCL2 CALCA
6	regulation of NMDA receptor activity	GO:2000310	9.69	OPRM1 CRH
7	response to ethanol	GO:0045471	9.69	OPRM1 CRH
8	positive regulation of glial cell proliferation	GO:0060252	9.68	IL6 IL1B
9	positive regulation of calcium ion import	GO:0090280	9.68	CRH CCL2
10	negative regulation of bone resorption	GO:0045779	9.68	IL6 CALCA
11	actin polymerization or depolymerization	GO:0008154	9.67	GHSR GHRL
12	positive regulation of growth	GO:0045927	9.67	GHSR GHRL
13	negative regulation of interleukin-1 beta production	GO:0032691	9.66	GHSR GHRL
14	adult feeding behavior	GO:0008343	9.65	GHSR GHRL
15	postsynaptic modulation of chemical synaptic transmission	GO:0099170	9.65	GHSR GHRL
16	negative regulation of lipid storage	GO:0010888	9.65	IL6 CRP
17	negative regulation of appetite	GO:0032099	9.64	GHSR CCK
18	negative regulation of tumor necrosis factor secretion	GO:1904468	9.64	GHSR GHRL
19	negative regulation of norepinephrine secretion	GO:0010700	9.63	GHSR CRH
20	growth hormone secretion	GO:0030252	9.62	GHSR GHRL
21	positive regulation of neuroinflammatory response	GO:0150078	9.61	IL6 IL1B
22	positive regulation of behavioral fear response	GO:2000987	9.61	CRH CCK
23	regulation of sensory perception of pain	GO:0051930	9.61	VIP OPRM1 CCK
24	negative regulation of tumor necrosis factor biosynthetic process	GO:0042536	9.6	GHSR GHRL
25	positive regulation of cortisol secretion	GO:0051464	9.58	GHRL CRH
26	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0035774	9.58	GHRL CRH CFTR
27	positive regulation of corticotropin secretion	GO:0051461	9.57	GHRL CRH
28	negative regulation of interleukin-6 biosynthetic process	GO:0045409	9.56	GHSR GHRL
29	hormone-mediated apoptotic signaling pathway	GO:0008628	9.55	SST CRH
30	inflammatory response	GO:0006954	9.55	IL6 IL1B CRP CRH CCL2
31	digestion	GO:0007586	9.54	SST GUCY2C CCK
32	regulation of transmission of nerve impulse	GO:0051969	9.51	GHSR GHRL
33	positive regulation of eating behavior	GO:1904000	9.49	GHSR GHRL
34	regulation of gastric motility	GO:1905333	9.48	GHSR GHRL
35	positive regulation of small intestine smooth muscle contraction	GO:1904349	9.46	GHSR GHRL
36	response to dexamethasone	GO:0071548	9.37	GHSR
37	positive regulation of small intestinal transit	GO:0120058	9.32	GHSR GHRL
38	G protein-coupled receptor signaling pathway	GO:0007186	9.32	VIP SST OPRM1 NTS GHSR GHRL
39	response to heat	GO:0009408	9.28	SST
40	negative regulation of circadian sleep/wake cycle, REM sleep	GO:0042322	9.26	GHRL CRH
41	positive regulation of appetite	GO:0032100	9.13	OPRM1 GHSR GHRL
42	signal transduction	GO:0007165	10.23	OPRM1 NTS IL1B GUCY2C GHSR CRH
43	positive regulation of cell proliferation	GO:0008284	10.06	VIP IL6 IL1B CRH CCK

Molecular functions related to Ileus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chloride transmembrane transporter activity	GO:0015108	9.32	SLC26A9 CFTR
2	bicarbonate transmembrane transporter activity	GO:0015106	9.26	SLC26A9 CFTR
3	neuropeptide hormone activity	GO:0005184	9.26	VIP NTS CRH CCK
4	peptide hormone receptor binding	GO:0051428	9.16	VIP CCK
5	hormone activity	GO:0005179	9.1	VIP SST GHRL CRH CCK CALCA

Sources

Sources for Ileus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia

Ileus (ILEUS)

Aliases & Classifications for Ileus

MalaCards integrated aliases for Ileus:

Classifications:

External Ids:

Summaries for Ileus

Related Diseases for Ileus

Diseases related to Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Ileus:

Symptoms & Phenotypes for Ileus

MGI Mouse Phenotypes related to Ileus:

Drugs & Therapeutics for Ileus

Drugs for Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: ileus

Genetic Tests for Ileus

Anatomical Context for Ileus

MalaCards organs/tissues related to Ileus:

Publications for Ileus

Articles related to Ileus:

Genes for Ileus

Genes related to Ileus (0 elite genes):

Variations for Ileus

Expression for Ileus

Pathways for Ileus

Pathways related to Ileus according to GeneCards Suite gene sharing:

GO Terms for Ileus

Cellular components related to Ileus according to GeneCards Suite gene sharing:

Biological processes related to Ileus according to GeneCards Suite gene sharing:

Molecular functions related to Ileus according to GeneCards Suite gene sharing:

Sources for Ileus