Ileus (ILEUS)

Categories: Gastrointestinal diseases
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Aliases & Classifications for Ileus

MalaCards integrated aliases for Ileus:

Name: Ileus 11 43 14 75
Ileus of Intestine 11


External Ids:

Disease Ontology 11 DOID:8440
MeSH 43 D045823
NCIt 49 C37979
SNOMED-CT 68 278524008
ICD10 31 K56.7
UMLS 71 C1258215

Summaries for Ileus

MalaCards based summary: Ileus, also known as ileus of intestine, is related to paralytic ileus and intestinal obstruction. An important gene associated with Ileus is GUCY2C (Guanylate Cyclase 2C), and among its related pathways/superpathways are Signal Transduction and TGF-Beta Pathway. The drugs Tramadol and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia: 75 Ileus is a disruption of the normal propulsive ability of the intestine. It can be caused by lack of... more...

Related Diseases for Ileus

Diseases related to Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1197)
# Related Disease Score Top Affiliating Genes
1 paralytic ileus 32.7 VIP IL6 CRP CALCA
2 intestinal obstruction 31.4 TNF SLC26A9 IL6 GUCY2C CRP CFTR
3 intussusception 31.1 VIP IL6 CRP CFTR
4 diverticulitis 30.9 TNF IL6 CRP
5 enterocolitis 30.5 TNF IL6 IL10 CRP
6 colonic benign neoplasm 30.5 TNF IL6 IL1B IL17A IL10
7 intestinal perforation 30.4 TNF IL6 IL10 CRP
8 nutritional deficiency disease 30.4 IL6 GHRL CRP
9 compartment syndrome 30.3 TNF IL6 CRP
10 pain agnosia 30.3 TNF OPRM1 IL6 IL1B IL10 CRP
11 gastroschisis 30.3 IL6 IL1B ICAM1
12 intestinal tuberculosis 30.3 TNF IFNG CRP
13 pancreatitis 30.3 TNF IL6 IL1B IL10 CRP CFTR
14 amyloidosis 30.3 TNF IL6 IL1B CRP
15 aspiration pneumonia 30.3 TNF IL6 IL1B CRP
16 ischemic colitis 30.3 TNF IL6 CRP
17 pheochromocytoma 30.2 VIP TNF IL6 IL1B CRP CALCA
18 peritonitis 30.2 TNF IL6 IL1B IL17A IL10 IFNG
19 guillain-barre syndrome 30.1 TNF IL17A ICAM1
20 duodenal ulcer 30.1 TNF IL6 IL1B IL10 CALCA
21 interstitial cystitis 30.1 TNF IL6 IL1B CALCA
22 appendicitis 30.1 TNF IL6 IL1B IL17A IL10 IFNG
23 crohn's disease 30.1 TNF IL6 IL1B IL17A IL10 IFNG
24 gas gangrene 30.1 TNF IL6 CRP
25 ileitis 30.0 TNF IL6 IL17A IL10
26 hydronephrosis 30.0 IL6 ICAM1 CRP CCL2
27 iron deficiency anemia 30.0 TNF IL6 CRP
28 inflammatory bowel disease 1 30.0 TNF IL6 IL1B IL17A IL10
29 abdominal tuberculosis 30.0 TNF IFNG CRP
30 acute pancreatitis 30.0 TNF IL6 IL1B IL10 ICAM1 CRP
31 aortic aneurysm 30.0 TNF IL6 IL1B IL10 CRP CCL2
32 alcohol use disorder 30.0 TNF OPRM1 IL6 IL1B CRP
33 cholangitis 30.0 TNF IL6 IL17A IL10 ICAM1 CRP
34 mesenteric lymphadenitis 30.0 TNF IL6 IL1B CRP
35 gastric dilatation 30.0 GHRL CRP
36 tuberculous peritonitis 30.0 IFNG CRP
37 short bowel syndrome 29.9 VIP SLC9A3 IL6 IL1B GHRL
38 cystitis 29.9 TNF IL6 IL17A CRP CCL2
39 peptic ulcer disease 29.9 TNF IL6 IL1B IL10 GHRL CRP
40 aspiration pneumonitis 29.9 TNF IL6 CRP
41 kawasaki disease 29.9 TNF CRP CCL2
42 henoch-schoenlein purpura 29.9 TNF IL6 ICAM1 CRP
43 angina pectoris 29.9 TNF IL6 ICAM1 CRP
44 urinary tract infection 29.9 TNF IL6 IL1B IL10 CRP
45 serum amyloid a amyloidosis 29.9 TNF IL6 CRP
46 gastroesophageal reflux 29.9 VIP TNF IL6 IL1B GHRL CCL2
47 demyelinating polyneuropathy 29.8 TNF IL6 CRP
48 diarrhea 29.8 TNF SLC9A3 IL6 IL1B IL10 IFNG
49 myelofibrosis 29.8 TNF IL1B IL17A CRP CCL2
50 toxic shock syndrome 29.8 TNF IL6 IL1B IL10 IFNG CRP

Graphical network of the top 20 diseases related to Ileus:

Diseases related to Ileus

Symptoms & Phenotypes for Ileus

GenomeRNAi Phenotypes related to Ileus according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 CALCA CCL2 CFTR CLCA1 CRP GHRL
2 no effect GR00402-S-2 10.17 CALCA CCL2 CFTR CLCA1 CRP GHRL

MGI Mouse Phenotypes related to Ileus:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.47 CALCA CCL2 CFTR CLCA1 CRP GHRL
2 digestive/alimentary MP:0005381 10.3 CCL2 CFTR GHRL GHSR GUCY2C ICAM1
3 immune system MP:0005387 10.3 CCL2 CFTR CLCA1 CRP GUCY2C ICAM1
4 endocrine/exocrine gland MP:0005379 10.29 CFTR GHRL ICAM1 IFNG IL10 IL17A
5 behavior/neurological MP:0005386 10.25 CALCA CCL2 CFTR GHRL GHSR GUCY2C
6 cardiovascular system MP:0005385 10.21 CALCA CCL2 CRP GUCY2C ICAM1 IFNG
7 neoplasm MP:0002006 10.2 CALCA CCL2 ICAM1 IFNG IL10 IL1B
8 normal MP:0002873 10.19 CALCA CCL2 CFTR GHRL IFNG IL10
9 liver/biliary system MP:0005370 10.11 CCL2 CFTR GUCY2C IFNG IL10 IL17A
10 no phenotypic analysis MP:0003012 10.07 CFTR GHSR IFNG IL10 IL17A OPRM1
11 hematopoietic system MP:0005397 10.03 CCL2 CFTR CLCA1 GHSR ICAM1 IFNG
12 reproductive system MP:0005389 10 CCL2 CFTR CLCA1 IFNG IL10 IL6
13 respiratory system MP:0005388 9.97 CALCA CFTR CLCA1 IFNG IL10 IL17A
14 mortality/aging MP:0010768 9.83 CALCA CCL2 CFTR CLCA1 GUCY2C ICAM1
15 integument MP:0010771 9.47 CALCA CCL2 CFTR CLCA1 GUCY2C ICAM1

Drugs & Therapeutics for Ileus

Drugs for Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 191)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
Methadone Approved Phase 4 76-99-3, 1095-90-5 4095
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
Orphenadrine Approved Phase 4 83-98-7 4601
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Ranitidine Approved, Withdrawn Phase 4 66357-59-3, 82530-72-1, 66357-35-5 3001055 5039
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
Histamine Approved, Investigational Phase 4 51-45-6 774
Clonidine Approved Phase 4 4205-91-8, 4205-90-7 2803 20179
Peppermint Approved Phase 4
Dimenhydrinate Approved Phase 4 523-87-5 10660
Simethicone Approved Phase 4 8050-81-5
Bismuth subsalicylate Approved, Vet_approved Phase 4 14882-18-9 53629521 16682734
Bisacodyl Approved Phase 4 603-50-9 2391
Sorbitol Approved, Investigational Phase 4 69-65-8, 50-70-4 453 6251 5780
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
Alvimopan Approved, Investigational Phase 4 156053-89-3 5488548
Nicotine Approved Phase 4 54-11-5 942 89594
27 Antirheumatic Agents Phase 4
28 Parasympatholytics Phase 4
29 Acetaminophen, hydrocodone drug combination Phase 4
Ketorolac Tromethamine Phase 4
31 Antiparkinson Agents Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Anti-Inflammatory Agents, Non-Steroidal Phase 4
34 Respiratory System Agents Phase 4
35 Antitussive Agents Phase 4
36 Cytochrome P-450 Enzyme Inhibitors Phase 4
37 Muscarinic Antagonists Phase 4
38 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
Bismuth Phase 4 7440-69-9 105143
40 Neuromuscular Nondepolarizing Agents Phase 4
41 Neuromuscular Blocking Agents Phase 4
Ranitidine bismuth citrate Phase 4
43 GABA Modulators Phase 4
44 Anti-Ulcer Agents Phase 4
45 Antacids Phase 4
46 Antihypertensive Agents Phase 4
Histamine phosphate Phase 4 51-74-1 134614
48 Histamine H2 Antagonists Phase 4
49 Histamine Antagonists Phase 4
50 Bismuth tripotassium dicitrate Phase 4

Interventional clinical trials:

(show top 50) (show all 173)
# Name Status NCT ID Phase Drugs
1 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
2 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Unknown status NCT02056405 Phase 4 Mosapride;Placebo
3 Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus Unknown status NCT02425774 Phase 4 Prucalopride;Placebo
4 The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus Unknown status NCT03176316 Phase 4 Naloxone
5 Comparative Randomized Controlled Trial Study of General Balanced Anesthesia Based on Opioid and Opioid Sparing Balanced Anesthesia for Cholecystectomy Surgery Via Laparoscopy: Intraoperative and Postoperative Outcomes Unknown status NCT02953210 Phase 4 dexter ketamine;Lidocaine Hydrochloride;Fentanyl Hydrochloride;Clonidine Hydrochloride;Midazolam Hydrochloride;Isoflurane Volatile Liquid;Rocuronium Injectable Solution;Propofol 1 % Injectable Suspension;Dexamethasone-21-Sulfobenzoate, Sodium Salt;Ranitidine Hydrochloride;Ondansetron Hydrochloride;Ketorolac Injectable Solution;Bupivacaine Hydrochloride
6 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4 gum
7 A Randomized Controlled Trial of the Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery: A Pilot Study Completed NCT02161367 Phase 4 Simethicone;Oral Suspending Vehicle
8 A New Approach of Neostigmine in Unavoidable Post Operative Ileus After Surgery Completed NCT00676377 Phase 4 Neostigmine;Saline
9 A Phase 4, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Postoperative Ileus in Subjects Undergoing Radical Cystectomy. Completed NCT00708201 Phase 4 Alvimopan;Placebo
10 Prospective Randomized Double Blind Study of the Effect of Gastrografin on Postoperative Ileus After Colorectal Surgery Completed NCT01440712 Phase 4 Gastrografin;physiological serum
11 The Impact of Visceral Osteopathic Treatment on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT02140710 Phase 4
12 Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery Completed NCT00509327 Phase 4 bisacodyl;glucosemonohydricum
13 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants- a Phase 4 Study Completed NCT01515696 Phase 4 Gastrografin;Sterile water
14 Parenteral Nutrition in Hospitalized Patients: Comparison of Two Commercially Available Lipid Emulsions Completed NCT01943409 Phase 4 Intralipid;ClinOleic
15 Effect of Perioperative Systemic Lignocaine on Postoperative Pain in Patients Undergoing Elective Open Abdominal Surgeries- a Double Blinded Randomized Control Trial Completed NCT01699919 Phase 4 Intravenous lignocaine
16 Preoperative Bowel Preparation Versus no Preparation Before Spinal Surgery: a Randomised Clinical Trial Completed NCT01879605 Phase 4 Docusate natrium and sorbitol;Bisacodyl
17 A Prospective Randomized Control Trial of The Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery Recruiting NCT04405037 Phase 4 Alvimopan
18 The Effects of Preoperative High-dose Dexamethasone on Inflammatory Response and Recovery After Emergency Laparotomy, a Randomized, Double-blind, Placebo-controlled Clinical Trial - AHA STEROID TRIAL Recruiting NCT04791566 Phase 4 Dexamethasone 1 mg/kg;Physiologic saline
19 A Double Blind, Randomized, Parallel Design Study to Evaluate the Effectiveness of Post-operative Dose of Alvimopan(Entereg) in Preventing Post-operative Ileus in Poly-traumatized Patients Terminated NCT03068975 Phase 4 Alvimopan;Placebo
20 Does Nicotine Gum Enhance Bowel Recovery After Colorectal Surgery? Terminated NCT01662115 Phase 4 Nicotine gum
21 Efficacy of Prucalopride in Critically Ill Patients With Paralytic Ileus; a Pilot Randomized Double-blind Controlled Trial Unknown status NCT04190173 Phase 3 Prucalopride;Placebo
22 A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI) in Subjects Undergoing Abdominal Operation Unknown status NCT01863407 Phase 3 DAM;Normal Saline
23 A Randomized Clinical Trial of Electroacupuncture Versus Fast-track Perioperative Program for Reducing Duration of Postoperative Ileus and Hospital Stay After Laparoscopic Colorectal Surgery Unknown status NCT02059603 Phase 3
24 Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve: A Potential New Therapeutical Intervention for Shortening Postoperative Ileus Unknown status NCT02524626 Phase 3
25 A Multicenter Phase III, Double-Blind, Placebo-Controlled, Parallel Study of ADL-8-2698 in Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00388479 Phase 3 Alvimopan
26 A Multicenter Phase III, Double-Blind, Placebo-Controlled, Parallel Study of ADL-8-2698 in Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00388401 Phase 3 Alvimopan
27 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Intravenous Methylnaltrexone (MOA-728) for the Treatment of Post Operative Ileus After Ventral Hernia Repair Completed NCT00528970 Phase 3 MOA-728;Placebo
28 A Phase 3, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI) Completed NCT00401375 Phase 3 Methylnaltrexone;Placebo
29 Electroacupuncture for Postoperative Ileus After Laparoscopic Colorectal Surgery: a Randomised Sham-controlled Pilot Study Completed NCT00464425 Phase 3
30 A Multicenter Phase III, Double-Blind, Placebo-Controlled, Parallel Study of ADL-8-2698 in Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00388258 Phase 3 Alvimopan
31 A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Intravenous Methylnaltrexone (MOA-728) for the Treatment of Post Operative Ileus. Completed NCT00387309 Phase 3 Methylnaltrexone (MOA-728)
32 Randomised Double-blind Placebo-controlled Trial of Gastrografin in the Therapeutic Management of Prolonged Postoperative Ileus Following Elective Surgery. Completed NCT01648972 Phase 2, Phase 3 Gastrografin;Placebo
33 Does Coffee Consumption Prevent or Shorten Postoperative Ileus After Colon Resection? A Prospective Randomized Clinical Trial Completed NCT01130675 Phase 3
34 Efficacy of Simo Decoction and Acupuncture or Chewing Gum Alone on Postoperative Ileus in Colorectal Cancer Resection: a Randomized Clinical Trial Completed NCT02813278 Phase 3
35 A Phase IIIb, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00205842 Phase 3 alvimopan
36 Randomized Control Trial on Seprafilm and Guardix in Preventing Ileus Completed NCT02168426 Phase 3
37 A Randomized Double-blind Placebo Controlled Trial of Prucalopride to Reduce the Duration of Postoperative Ileus in Patients Undergoing Elective Colorectal Surgery Completed NCT02947269 Phase 3 Prucalopride;Placebo Oral Capsule
38 Time to Transit Recovery After Treatment With Naloxegol in Cardiac Surgery Intensive Care Trial Completed NCT04433390 Phase 3 Naloxegol;inert tablet
39 Effectiveness of Mouth Dissolving Mosapride Tablets on Enhancing Gut Recovery After Cesarean Section: Randomized Double-blind, Placebo-controlled Clinical Trial Completed NCT03477266 Phase 3 Mosapride;Placebo Oral Tablet
40 Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy Completed NCT00600158 Phase 3 bupivacaine with hydromorphone;lidocaine
41 The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section: Randomized Controlled Trial Completed NCT01131416 Phase 2, Phase 3
42 A Multicentre, Randomised, Double-blind, Placebo-Controlled Study to Evaluate the Safety of TZP-101 (IV Ulimorelin) Administered Post-Operatively in Patients Who Have Undergone Partial Bowel Resection Completed NCT01710982 Phase 3 TZP-101
43 A Randomized Control Trial Evaluating the Utility of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery Recruiting NCT04144933 Phase 3 Acetaminophen, Gabapentin;Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine;Dexamethasone, Ondansetron;Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate;Lidocaine 1% Injectable Solution, Sufentanil;Sevoflurane, Sufentanil
44 A Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Safety and Efficacy of LB1148 in Accelerating the Time to Return of Bowel Function in Subjects Undergoing Planned Bowel Resection (INTEGRITY) Active, not recruiting NCT05470387 Phase 3 LB1148;Placebo
45 Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery (PESTI Trial) Not yet recruiting NCT05334485 Phase 2, Phase 3 Pyridostigmine Bromide
46 A Prospective Randomized Control Trial of The Effectiveness of Entereg as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery Terminated NCT02742181 Phase 3 Alvimopan
47 Effects of Chewing Gum Against Postoperative Ileus After Pancreaticoduodenectomy - a Randomized Controlled Trial Terminated NCT02319512 Phase 3
48 A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Meropenem in Hospitalized Children With Complicated Intra-Abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
49 Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer: a Randomized Controlled Trial Withdrawn NCT01389986 Phase 2, Phase 3
50 Evaluation of Naloxegol, a Peripherally Acting µ-opioid Receptor Antagonist, in the Prevention of Postoperative Ileus After Cystectomy Unknown status NCT04219046 Phase 2 Naloxégol oxalate;Placebo oral tablet

Search NIH Clinical Center for Ileus

Cochrane evidence based reviews: ileus

Genetic Tests for Ileus

Anatomical Context for Ileus

Organs/tissues related to Ileus:

MalaCards : Colon, Small Intestine, Liver, Lymph Node, Smooth Muscle, Spinal Cord, Pancreas

Publications for Ileus

Articles related to Ileus:

(show top 50) (show all 12811)
# Title Authors PMID Year
Colonic gallstone ileus treated by a transanal ileus tube followed by spontaneous gallstone dislodgement: A case report. 62
35898849 2023
High-quality read-based phasing of cystic fibrosis cohort informs genetic understanding of disease modification. 62
36386424 2023
Clinical impact of severe acute kidney injury on post-operative and brain injury outcomes in preterm infants following surgical necrotizing enterocolitis. 62
36093832 2022
Impact of post-operative paralytic ileus on post-operative outcomes after surgery for colorectal cancer: a single-institution, retrospective study. 62
35429250 2022
Minimally Invasive Lower Anterior Resections - Better than Open But Not All the Same. 62
36469507 2022
Effectiveness of preventive B-Lynch sutures in patients at a high risk of postpartum hemorrhage. 62
36089573 2022
The Role of Laparoscopic Treatment of Choledochal Malformation in Europe: A Single-Center Experience and Review of the Literature. 62
35764302 2022
Retrorectus mesh reinforcement of ileostomy site fascial closure: stoma closure and reinforcement (SCAR) trial phase I/II results. 62
36167868 2022
Benefits and risks of diverting stoma creation during rectal cancer surgery. 62
36472048 2022
Ileus rate after abdominal wall reconstruction: a retrospective analysis of two clinical trials. 62
36319900 2022
Shenhuang plaster ameliorates the Inflammation of postoperative ileus through inhibiting PI3K/Akt/NF-κB pathway. 62
36411615 2022
Nomogram for prediction of prolonged postoperative ileus after colorectal resection. 62
36474177 2022
Anterior lumbar spinal fusion surgery associated with lower risk of stroke, pneumonia, and infection compared to posterior lumbar spinal fusion surgery. 62
36439895 2022
Effects of liberal oral intake on postoperative outcomes after elective laparoscopic gynaecological surgery: A randomised controlled clinical trial. 62
35384093 2022
The Effect of Xylitol Gum Chewing After Cesarean on Bowel Functions: A Randomized Controlled Study. 62
35750598 2022
Gastrocolic fistula in Crohn's disease: A case report and review of the literature. 62
36212753 2022
Effect of remote ischemic preconditioning in patients undergoing laparoscopic colorectal cancer surgery: a randomized controlled trial. 62
36469647 2022
Disparities in obstetric morbidity by maternal level of education. 62
33317357 2022
Same day discharge following elective, minimally invasive, colorectal surgery : A review of enhanced recovery protocols and early outcomes by the SAGES Colorectal Surgical Committee with recommendations regarding patient selection, remote monitoring, and successful implementation. 62
36131162 2022
Retrospective Analysis of Complications After Gonadal Vein Interventions for Pelvic Venous Disorder. 62
36423473 2022
Risk factors for postoperative urinary retention in patients undergoing colorectal surgery: a systematic review and meta-analysis. 62
36357736 2022
Development and Validation of Machine Learning Models to Predict Readmission After Colorectal Surgery. 62
36070116 2022
Mechanistic Study of Coffee Effects on Gut Microbiota and Motility in Rats. 62
36432563 2022
Appendiceal Mucinous Tumor Presenting as Recurrent Bowel Obstruction. 62
36428891 2022
[Chinese experts consensus on the prevention and treatment of complications caused by intraperitoneal perfusion chemotherapy for gastrointestinal tumors (2022 edition)]. 62
36396367 2022
Initial experience with 161 extraperitoneal laparoscopic radical cystectomy procedures: Comparison with transabdominal laparoscopic radical cystectomy. 62
36349911 2022
AUGS-IUGA Joint clinical consensus statement on enhanced recovery after urogynecologic surgery. 62
36161507 2022
AUGS-IUGA Joint Clinical Consensus Statement on Enhanced Recovery After Urogynecologic Surgery: Developed by the Joint Writing Group of the International Urogynecological Association and the American Urogynecologic Society. Individual writing group members are noted in the Acknowledgements section. 62
36288110 2022
Complex Foley Catheter Placement After Radical Prostatectomy. 62
36402269 2022
Early vs. standard reversal ileostomy: a systematic review and meta-analysis. 62
35596904 2022
Alvimopan for Enhanced Gastrointestinal Recovery after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Randomized Controlled Trial. 62
36102565 2022
The impact of enhanced recovery after gynaecological surgery: A systematic review and meta-analysis. 62
36356373 2022
Postoperative ileus. What cannot be cured must be endured? 62
36448991 2022
Low-intensity transcutaneous auricular vagus nerve stimulation reduces postoperative ileus after laparoscopic radical resection of colorectal cancer: a randomized controlled trial. 62
36326770 2022
The great migration: a rare case of post-cholecystectomy gallstone ileus. 62
36394190 2022
Cost of postoperative ileus following colorectal surgery: A cost analysis in the Australian public hospital setting. 62
35737846 2022
Ileus in patients treated with immune checkpoint inhibitors: A retrospective, pharmacovigilance study using Food and Drug Administration Adverse Event Reporting System database. 62
35689298 2022
Laparoscopic versus open repair of congenital duodenal obstruction: a systematic review and meta-analysis. 62
36053328 2022
Gastrointestinal procedures and anastomoses can be safely performed during complex abdominal wall reconstruction. 62
36450997 2022
Causes of acute abdomen, preferred imaging methods, and prognoses in geriatric patients presenting to the emergency department with abdominal pain. 62
36449801 2022
Transanal ileus catheter combined with nasal ileus catheter in the treatment of malignant ileus in 14 cases: a case series and literature review. 62
36464968 2022
Laparoscopic port site Richter's hernia after robot-assisted radical prostatectomy. 62
36341190 2022
Electroacupuncture vs Sham Electroacupuncture in the Treatment of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer: A Multicenter, Randomized Clinical Trial. 62
36322060 2022
The success rate of robotic natural orifice intracorporeal anastomosis and transrectal extraction (NICE procedure) in a large cohort of consecutive unselected patients. 62
36418639 2022
Preoperative Splenic Artery Embolization for Massive Splenomegaly in Children: A Single Center Experience. 62
36445756 2022
Prone Transpsoas Lateral Lumbar Interbody Fusion for Degenerative Lumbar Spine Disease: Case Series With an Operative Video Using Fluoroscopy-Based Instrument Tracking Guidance. 62
36227242 2022
Risk factors for complications in patients with Hirschsprung disease while awaiting surgery: Beware of bowel perforation. 62
35354528 2022
[Complications in urological surgery: Bladder surgery]. 62
36410866 2022
Cystic fibrosis with liver involvement in adults has a benign course. Results from a tertiary referral centre cohort. 62
36353964 2022
A case of sigmoid colon volvulus with transanal ileus tube placement and Sharon's operation performed safely. 62
36381983 2022

Variations for Ileus

Expression for Ileus

Search GEO for disease gene expression data for Ileus.

Pathways for Ileus

Pathways related to Ileus according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.35 TNF OPRM1 IL6 IL1B IL17A IL10
Show member pathways
Show member pathways
12.68 IFNG IL10 IL17A IL1B IL6 TNF
Show member pathways
12.63 TNF IL6 IL1B IL17A IL10 IFNG
7 12.62 CCL2 IFNG IL10 IL17A IL1B TNF
Show member pathways
Show member pathways
Show member pathways
11 12.24 TNF SLC9A3 IL6 IL1B IL10
Show member pathways
12.18 TNF IL17A IL10 IFNG
13 12.16 TNF IL6 IL1B IL10 IFNG
14 12.05 TNF IL6 IL10 IFNG
Show member pathways
11.95 IL6 IL17A ICAM1 CFTR
17 11.95 TNF IL1B IL17A IL10 IFNG
Show member pathways
11.93 IL6 IL1B IL17A IFNG
19 11.88 TNF IL1B IL17A IL10 IFNG
Show member pathways
11.88 TNF IL6 IL1B IL17A IL10 IFNG
21 11.82 TNF IL6 IL1B ICAM1 CCL2
Show member pathways
23 11.8 IL6 IL1B IL17A IFNG
24 11.8 TNF IL6 IL1B IL10 IFNG
25 11.79 IL6 IL10 IFNG CCL2
Show member pathways
11.78 IL6 CRP CCL2
27 11.78 IL6 IFNG ICAM1
28 11.77 IL6 IL10 IFNG
29 11.77 CRP IFNG IL10 IL6 TNF
30 11.74 TNF IL6 IL10 ICAM1
31 11.74 TNF IL6 IL1B IL10
Show member pathways
11.71 TNF IL6 IL10 IFNG
Show member pathways
34 11.69 TNF IL6 IL1B CCL2 CALCA
35 11.64 TNF IL10 ICAM1 CCL2
36 11.63 TNF IL6 IFNG CCL2
37 11.59 TNF IL10 CCL2
38 11.59 TNF IL1B IFNG CCL2
39 11.54 TNF IL6 CCL2
40 11.51 TNF IL6 CCL2
42 11.44 IL1B IFNG ICAM1
43 11.44 TNF IL6 IL1B IL10
Show member pathways
11.43 TNF IL10 IFNG
45 11.37 CCL2 IL1B IL6 TNF
46 11.32 TNF IL6 ICAM1
47 11.29 TNF IFNG CCL2
48 11.27 IFNG IL17A IL1B IL6 TNF
49 11.26 TNF OPRM1 IL6 IL1B IL17A IL10
50 11.25 IL1B IFNG ICAM1 CCL2

GO Terms for Ileus

Cellular components related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 VIP TNF IL6 IL1B IL17A IL10
2 extracellular space GO:0005615 9.7 CALCA CCL2 CLCA1 CRP GHRL ICAM1

Biological processes related to Ileus according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.54 TNF OPRM1 IL6 IL1B IL10 IFNG
2 inflammatory response GO:0006954 10.36 TNF IL6 IL1B IL17A CRP CCL2
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.29 TNF IL6 IL1B IL10
4 immune response GO:0006955 10.24 CCL2 IFNG IL10 IL17A IL1B IL6
5 positive regulation of interleukin-1 beta production GO:0032731 10.19 TNF IL6 IL17A IFNG
6 defense response to Gram-positive bacterium GO:0050830 10.19 CRP IL17A IL1B IL6 TNF
7 monocyte chemotaxis GO:0002548 10.18 IL6 CCL2 CALCA
8 lipopolysaccharide-mediated signaling pathway GO:0031663 10.16 CCL2 IL1B TNF
9 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.16 TNF IL6 IL10
10 positive regulation of cytokine production GO:0001819 10.16 TNF IL1B IL10 IFNG
11 negative regulation of interleukin-6 production GO:0032715 10.16 TNF IL10 GHSR GHRL
12 humoral immune response GO:0006959 10.15 CCL2 IFNG IL6 TNF
13 liver regeneration GO:0097421 10.14 IL10 IL6 TNF
14 positive regulation of interleukin-8 production GO:0032757 10.14 TNF IL6 IL1B CALCA
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.12 TNF IL6 IL17A
16 negative regulation of neurogenesis GO:0050768 10.12 TNF IL6 IL1B
17 positive regulation of sprouting angiogenesis GO:1903672 10.11 IL10 GHSR GHRL
18 positive regulation of osteoclast differentiation GO:0045672 10.11 IFNG IL17A TNF
19 positive regulation of glial cell proliferation GO:0060252 10.08 TNF IL6 IL1B
20 regulation of insulin secretion GO:0050796 10.08 TNF IL6 IL1B IFNG
21 regulation of sensory perception of pain GO:0051930 10.06 VIP OPRM1 IL10
22 chloride transport GO:0006821 10.05 SLC6A14 SLC26A9 CLCA1 CFTR
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.04 TNF IL1B IFNG
24 positive regulation of interleukin-6 production GO:0032755 10.02 IFNG IL17A IL1B IL6 TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.01 TNF IL1B IL10
26 positive regulation of NMDA glutamate receptor activity GO:1904783 10 IFNG CCL2
27 growth hormone secretion GO:0030252 10 GHSR GHRL
28 negative regulation of cytokine production involved in immune response GO:0002719 10 TNF IL10
29 astrocyte activation GO:0048143 10 TNF IL1B IFNG
30 positive regulation of chemokine production GO:0032722 10 TNF IL6 IL1B IFNG
31 positive regulation of fever generation GO:0031622 9.99 TNF IL1B
32 sequestering of triglyceride GO:0030730 9.98 IL1B TNF
33 regulation of transmission of nerve impulse GO:0051969 9.98 GHRL GHSR
34 positive regulation of eating behavior GO:1904000 9.97 GHRL GHSR
35 leukocyte migration GO:0050900 9.97 TNF IL1B ICAM1
36 regulation of gastric motility GO:1905333 9.96 GHSR GHRL
37 positive regulation of small intestine smooth muscle contraction GO:1904349 9.96 GHSR GHRL
38 positive regulation of nitrogen compound metabolic process GO:0051173 9.95 TNF IFNG
39 positive regulation of small intestinal transit GO:0120058 9.93 GHSR GHRL
40 positive regulation of vitamin D biosynthetic process GO:0060557 9.92 TNF IFNG
41 chronic inflammatory response to antigenic stimulus GO:0002439 9.92 TNF IL10
42 positive regulation of neuroinflammatory response GO:0150078 9.91 IL1B IL6 TNF
43 positive regulation of nitric oxide biosynthetic process GO:0045429 9.91 TNF OPRM1 IL1B IFNG
44 cellular response to lipopolysaccharide GO:0071222 9.9 TNF IL6 IL1B IL10 GHSR CCL2
45 negative regulation of lipid storage GO:0010888 9.88 TNF IL6 CRP
46 vascular endothelial growth factor production GO:0010573 9.73 TNF IL6 IL1B
47 positive regulation of appetite GO:0032100 9.43 OPRM1 GHSR GHRL
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.1 TNF IL1B IFNG

Molecular functions related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.44 TNF IL6 IL1B IL17A IL10 IFNG

Sources for Ileus

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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