Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
ILEUS
MCID: ILS001
MIFTS: 50

Ileus (ILEUS)

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Ileus

About this section

MalaCards integrated aliases for Ileus:

Name: Ileus 12 44 15
Ileus of Intestine 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8440
MeSH 44 D045823
NCIt 50 C37979
SNOMED-CT 67 278524008
ICD10 32 K56.7
UMLS 71 C1258215
Sources

Summaries for Ileus

About this section
MalaCards based summary : Ileus, also known as ileus of intestine, is related to meconium ileus and paralytic ileus. An important gene associated with Ileus is GUCY2C (Guanylate Cyclase 2C), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Ketorolac and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and pancreas, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 74 Ileus is a disruption of the normal propulsive ability of the intestine. It can be caused by lack of... more...

Sources

Related Diseases for Ileus

About this section

Diseases related to Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 956)
# Related Disease Score Top Affiliating Genes
1 meconium ileus 32.6 SLC9A3 SLC6A14 SLC26A9 GUCY2C CLCA1 CFTR
2 paralytic ileus 32.2 VIP MLN F2 CRP
3 intestinal pseudo-obstruction 32.0 SST MLN CFTR
4 intestinal obstruction 31.5 MLN IL6 GUCY2C CRP CFTR
5 cholelithiasis 31.2 SST CRP CCK
6 intussusception 31.0 VIP IL6 CRP CFTR
7 cholecystitis 30.9 F2 CCK CALCA
8 diverticulitis 30.9 TNF IL6 CRP
9 peritonitis 30.9 TNF IL6 IL1B F2 CRP
10 appendicitis 30.9 TNF IL6 IL1B CRP
11 cystic fibrosis 30.9 VIP TNF SLC9A3 SLC26A9 IL6 IL1B
12 volvulus of midgut 30.9 SST MLN GUCY2C F2 CRP
13 cholecystolithiasis 30.8 SST CRP CCK
14 enterocolitis 30.7 TNF IL6 CRP
15 crohn's disease 30.6 TNF IL6 IL1B CRP
16 intestinal perforation 30.6 TNF IL6 CRP
17 choledocholithiasis 30.3 F2 CRP CCK
18 ulcerative colitis 30.3 TNF IL6 IL1B CRP
19 lymphadenitis 30.2 TNF IL1B CRP
20 hernia, hiatus 30.2 MLN GHRL CRP
21 amyloidosis 30.2 TNF IL6 IL1B CRP
22 perinatal necrotizing enterocolitis 30.2 TNF IL6 IL1B CRP
23 toxic shock syndrome 30.1 TNF IL6 IL1B CRP
24 gallbladder disease 30.1 SST MLN CRP CFTR CCK
25 hypothyroidism 30.1 TNF SST F2 CRP CALCA
26 pain agnosia 30.1 TNF OPRM1 IL6 IL1B CRH CCK
27 gastroenteritis 30.1 TNF MLN IL6 IL1B CRP CALCA
28 vipoma 30.1 VIP SST CALCA
29 obstructive jaundice 30.1 TNF IL6 F2 CRP
30 exocrine pancreatic insufficiency 30.1 TNF CFTR CCK
31 peptic ulcer disease 30.1 TNF SST IL1B GHRL
32 cholangitis 30.0 TNF SST IL6 F2 CRP CFTR
33 aortic aneurysm, familial abdominal, 1 30.0 TNF IL6 IL1B CRP
34 compartment syndrome 30.0 TNF IL6 F2 CRP
35 acute pancreatitis 30.0 TNF SST IL6 IL1B CRP CFTR
36 aspiration pneumonia 30.0 TNF IL6 F2 CRP
37 gastroparesis 30.0 SST MLN GHSR GHRL CCK
38 iron deficiency anemia 30.0 TNF IL6 GHRL CRP
39 constipation 30.0 VIP SST OPRM1 MLN IL6 GUCY2C
40 abdominal tuberculosis 30.0 TNF F2 CRP
41 back pain 29.9 IL6 IL1B CALCA
42 aortitis 29.9 TNF IL6 IL1B CRP
43 pancreatitis 29.9 TNF SST IL6 IL1B CRP CFTR
44 gastroschisis 29.9 IL6 IL1B F2
45 neurogenic bowel 29.9 VIP MLN
46 tetanus 29.9 TNF IL6 IL1B CRP
47 chickenpox 29.9 TNF IL6 CRP
48 anorexia nervosa 29.9 GHSR GHRL CRH CCK
49 emphysematous cholecystitis 29.9 F2 CRP
50 polyneuropathy 29.9 TNF IL6 IL1B CRP

Graphical network of the top 20 diseases related to Ileus:



Diseases related to Ileus
Sources

Symptoms & Phenotypes for Ileus

About this section

MGI Mouse Phenotypes related to Ileus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.19 CCK CFTR CLCA1 CRH CRP F2
2 digestive/alimentary MP:0005381 10.11 CFTR F2 GHRL GHSR GUCY2C IL6
3 endocrine/exocrine gland MP:0005379 10.1 CCK CFTR CRH F2 GHRL IL6
4 immune system MP:0005387 10.06 CCK CFTR CLCA1 CRH CRP F2
5 adipose tissue MP:0005375 10.01 CRH GHRL GHSR GUCY2C IL6 OPRM1
6 integument MP:0010771 9.61 CLCA1 CRH F2 GUCY2C IL1B IL6
7 no phenotypic analysis MP:0003012 9.17 CCK CFTR CRH GHSR OPRM1 SST
Sources

Drugs & Therapeutics for Ileus

About this section

Drugs for Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 165)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4
Prucalopride Approved Phase 4 179474-81-8
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Peppermint Approved Phase 4
8
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
9
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
11
Methadone Approved Phase 4 76-99-3 4095
12
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
15
Orphenadrine Approved Phase 4 83-98-7 4601
16
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
17
Bisacodyl Approved Phase 4 603-50-9
18
Dimenhydrinate Approved Phase 4 523-87-5 441281
19
Simethicone Approved Phase 4 8050-81-5
20
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
21
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
22
Alvimopan Approved, Investigational Phase 4 156053-89-3 5488548
23
Nicotine Approved Phase 4 54-11-5 942 89594
24 Anesthetics Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Analgesics, Non-Narcotic Phase 4
27 Cyclooxygenase Inhibitors Phase 4
28 Psychotropic Drugs Phase 4
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4
30 Anesthetics, Intravenous Phase 4
31 Cholinergic Antagonists Phase 4
32 Antirheumatic Agents Phase 4
33 Analgesics Phase 4
34 Anesthetics, General Phase 4
35 Anti-Anxiety Agents Phase 4
36 Narcotics Phase 4
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38 Analgesics, Opioid Phase 4
39 Antipyretics Phase 4
40 Sodium Channel Blockers Phase 4
41 Anti-Arrhythmia Agents Phase 4
42 Anesthetics, Dissociative Phase 4
43 Diuretics, Potassium Sparing Phase 4
44 Excitatory Amino Acid Antagonists Phase 4
45 Anesthetics, Local Phase 4
46 Ketorolac Tromethamine Phase 4
47 Parasympatholytics Phase 4
48 Respiratory System Agents Phase 4
49 Anticonvulsants Phase 4
50 Acetaminophen, hydrocodone drug combination Phase 4

Interventional clinical trials:

(show top 50) (show all 154)
# Name Status NCT ID Phase Drugs
1 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Unknown status NCT02056405 Phase 4 Mosapride;Placebo
2 Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus Unknown status NCT02425774 Phase 4 Prucalopride;Placebo
3 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4 gum
4 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
5 A Phase 4, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Postoperative Ileus in Subjects Undergoing Radical Cystectomy. Completed NCT00708201 Phase 4 Alvimopan;Placebo
6 Prospective Randomized Double Blind Study of the Effect of Gastrografin on Postoperative Ileus After Colorectal Surgery Completed NCT01440712 Phase 4 Gastrografin;physiological serum
7 A Randomized Controlled Trial of the Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery: A Pilot Study Completed NCT02161367 Phase 4 Simethicone;Oral Suspending Vehicle
8 A New Approach of Neostigmine in Unavoidable Post Operative Ileus After Surgery Completed NCT00676377 Phase 4 Neostigmine;Saline
9 The Impact of Visceral Osteopathic Treatment on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT02140710 Phase 4
10 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants- a Phase 4 Study Completed NCT01515696 Phase 4 Gastrografin;Sterile water
11 Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery Completed NCT00509327 Phase 4 bisacodyl;glucosemonohydricum
12 The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus Recruiting NCT03176316 Phase 4 Naloxone
13 A Prospective Randomized Control Trial of The Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery Recruiting NCT04405037 Phase 4 Alvimopan
14 A Double Blind, Randomized, Parallel Design Study to Evaluate the Effectiveness of Post-operative Dose of Alvimopan(Entereg) in Preventing Post-operative Ileus in Poly-traumatized Patients Terminated NCT03068975 Phase 4 Alvimopan;Placebo
15 Does Nicotine Gum Enhance Bowel Recovery After Colorectal Surgery? Terminated NCT01662115 Phase 4 Nicotine gum
16 A Feasibility Randomized Trial of Intestinal Lavage for the Treatment of Severe C. Difficile Infections Unknown status NCT02466698 Phase 2, Phase 3 Vancomycin;PEG;Metronidazole
17 A Prospective Randomized Control Trial of The Effectiveness of Entereg as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery Unknown status NCT02742181 Phase 3 Alvimopan
18 Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve: A Potential New Therapeutical Intervention for Shortening Postoperative Ileus Unknown status NCT02524626 Phase 3
19 A Randomized Clinical Trial of Electroacupuncture Versus Fast-track Perioperative Program for Reducing Duration of Postoperative Ileus and Hospital Stay After Laparoscopic Colorectal Surgery Unknown status NCT02059603 Phase 3
20 A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI) in Subjects Undergoing Abdominal Operation Unknown status NCT01863407 Phase 3 DAM;Normal Saline
21 A Randomized Double-blind Placebo Controlled Trial of Prucalopride to Reduce the Duration of Postoperative Ileus in Patients Undergoing Elective Colorectal Surgery Unknown status NCT02947269 Phase 3 Prucalopride;Placebo Oral Capsule
22 Does Coffee Consumption Prevent or Shorten Postoperative Ileus After Colon Resection? A Prospective Randomized Clinical Trial Completed NCT01130675 Phase 3
23 A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Intravenous Methylnaltrexone (MOA-728) for the Treatment of Post Operative Ileus. Completed NCT00387309 Phase 3 Methylnaltrexone (MOA-728)
24 Randomized Control Trial on Seprafilm and Guardix in Preventing Ileus Completed NCT02168426 Phase 3
25 Efficacy of Simo Decoction and Acupuncture or Chewing Gum Alone on Postoperative Ileus in Colorectal Cancer Resection: a Randomized Clinical Trial Completed NCT02813278 Phase 3
26 A Multicenter Phase III, Double-Blind, Placebo-Controlled, Parallel Study of ADL-8-2698 in Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00388479 Phase 3 Alvimopan
27 A Multicenter Phase III, Double-Blind, Placebo-Controlled, Parallel Study of ADL-8-2698 in Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00388401 Phase 3 Alvimopan
28 A Multicenter Phase III, Double-Blind, Placebo-Controlled, Parallel Study of ADL-8-2698 in Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00388258 Phase 3 Alvimopan
29 A Phase IIIb, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Opioid-Induced Postoperative Bowel Dysfunction/Postoperative Ileus Completed NCT00205842 Phase 3 alvimopan
30 Electroacupuncture for Postoperative Ileus After Laparoscopic Colorectal Surgery: a Randomised Sham-controlled Pilot Study Completed NCT00464425 Phase 3
31 A Phase 3, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI) Completed NCT00401375 Phase 3 Methylnaltrexone;Placebo
32 Randomised Double-blind Placebo-controlled Trial of Gastrografin in the Therapeutic Management of Prolonged Postoperative Ileus Following Elective Surgery. Completed NCT01648972 Phase 2, Phase 3 Gastrografin;Placebo
33 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Intravenous Methylnaltrexone (MOA-728) for the Treatment of Post Operative Ileus After Ventral Hernia Repair Completed NCT00528970 Phase 3 MOA-728;Placebo
34 Effectiveness of Mouth Dissolving Mosapride Tablets on Enhancing Gut Recovery After Cesarean Section: Randomized Double-blind, Placebo-controlled Clinical Trial Completed NCT03477266 Phase 3 Mosapride;Placebo Oral Tablet
35 The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section: Randomized Controlled Trial Completed NCT01131416 Phase 2, Phase 3
36 Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy Completed NCT00600158 Phase 3 bupivacaine with hydromorphone;lidocaine
37 A Multicentre, Randomised, Double-blind, Placebo-Controlled Study to Evaluate the Safety of TZP-101 (IV Ulimorelin) Administered Post-Operatively in Patients Who Have Undergone Partial Bowel Resection Completed NCT01710982 Phase 3 TZP-101
38 Efficacy of Prucalopride in Critically Ill Patients With Paralytic Ileus; a Pilot Randomized Double-blind Controlled Trial Recruiting NCT04190173 Phase 3 Prucalopride;Placebo
39 Time to Transit Recovery After Treatment With Naloxegol in Cardiac Surgery Intensive Care Trial Recruiting NCT04433390 Phase 3 Naloxegol;inert tablet
40 Effects of Chewing Gum Against Postoperative Ileus After Pancreaticoduodenectomy - a Randomized Controlled Trial Terminated NCT02319512 Phase 3
41 Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer: a Randomized Controlled Trial Withdrawn NCT01389986 Phase 2, Phase 3
42 Effect of Daikenchuto (TJ-100) on Intestinal Dysmotility and For the Prevention of Postoperative Paralytic Ileus in Patients Undergoing Pancreaticoduodenectomy: A Multicenter, Randomized, Placebo-Controlled Phase II Trial Unknown status NCT01607307 Phase 2 Oral/enteral TJ-100 solution;Oral/enteral placebo solution
43 A Phase II Double-Blind Randomized Parallel Group Study of Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus Completed NCT01367548 Phase 2 IV Methylnaltrexone (MNTX);Placebo
44 A Phase II Randomized Controlled Trial of Acupuncture for Reduction of Post-Colectomy Ileus Completed NCT00402961 Phase 2
45 A Randomized, Controlled, Double-blind Efficacy and Tolerability Study Of Prucalopride For The Treatment Of Postoperative Ileus In Patients Undergoing Gastrointestinal Surgery Completed NCT02004652 Phase 2 Prucalopride;Placebo
46 A Randomized, Controlled, Open-Label Tolerability And Efficacy Study Of TU-100 For The Treatment Of Postoperative Ileus In Patients Undergoing Laparotomy For Large Bowel Resection Completed NCT00266461 Phase 2 Daikenchuto Extract Granules (TU-100)
47 A Phase II, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety and Efficacy of Ipamorelin Compared to Placebo for the Management of Post-Operative Ileus in Patients Completed NCT00672074 Phase 2 Ipamorelin;placebo
48 The Effect of Gum Chewing on Postoperative Ileus After Gynecologic Surgery. Completed NCT01579175 Phase 1, Phase 2
49 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Assess Efficacy and Safety of TZP-101 When Administered as 30 Minute i.v. Infusion for POI to Subjects Undergoing Major Open Abdominal Surgery Completed NCT00617552 Phase 2 5% dextrose in water;TZP-101;TZP-101;TZP-101;TZP-101;TZP-101;TZP-101;TZP-101
50 A Randomized, Double-Blinded, Placebo-Controlled Trial of TU-100 in Patients Undergoing Laparoscopic Colectomy Completed NCT02232893 Phase 2 Daikenchuto (TU-100);Placebo

Search NIH Clinical Center for Ileus

Cochrane evidence based reviews: ileus

Sources

Genetic Tests for Ileus

About this section
Sources

Anatomical Context for Ileus

About this section

MalaCards organs/tissues related to Ileus:

40
Colon, Small Intestine, Pancreas, Kidney, Lymph Node, Smooth Muscle, Appendix
Sources

Publications for Ileus

About this section

Articles related to Ileus:

(show top 50) (show all 11882)
# Title Authors PMID Year
1
Early Versus Traditional Oral Feeding Following Elective Colorectal Surgery: A Literature Review. 61
33595962 2021
2
Diagnostic decision-making tool for imaging term neonatal bowel obstruction. 61
33097229 2021
3
Risk factors for postoperative ileus after oblique lateral interbody fusion: a multivariate analysis. 61
33031922 2021
4
Gallstone obstruction at the proximal ileum in an elderly woman: CT findings. 61
33363684 2021
5
Ventral hernia repair by totally extraperitoneal approach (VTEP): technique description and feasibility study. 61
32240382 2021
6
A postdischarge venous thromboembolism risk calculator for inflammatory bowel disease surgery. 61
33077197 2021
7
Feasibility of Enhanced Recovery in Emergency Colorectal Operation. 61
33069852 2021
8
Evaluating outcomes of primary anastomosis versus Hartmann's procedure in sigmoid volvulus: A retrospective-cohort study. 61
33520215 2021
9
Defining postoperative ileus and associated risk factors in patients undergoing radical cystectomy with an Enhanced Recovery After Surgery (ERAS) program. 61
32745002 2021
10
Opioid Induced Constipation and Acupuncture: A Case Discussion. 61
33556492 2021
11
Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma. 61
33608849 2021
12
The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review. 61
33579260 2021
13
Impact of intravenous lidocaine on clinical outcomes of patients with ARDS during COVID-19 pandemia (LidoCovid): A structured summary of a study protocol for a randomised controlled trial. 61
33573681 2021
14
Bouveret syndrome: a rare form of gallstone ileus. 61
33526527 2021
15
Meta-analysis of randomised controlled trials comparing intracorporeal versus extracorporeal anastomosis in laparoscopic right hemicolectomy: upgrading the level of evidence. 61
33534124 2021
16
Gastrointestinal motility has more of an impact on postoperative recovery than you might expect. 61
32624336 2021
17
Subtotal colectomy, extended right hemicolectomy, left hemicolectomy, or splenic flexure colectomy for splenic flexure tumors: a network meta-analysis. 61
32975595 2021
18
Laparoscopic Fowler-Stephens orchidopexy for intra-abdominal cryptorchid testis: a single institution experience. 61
33522214 2021
19
The role of tibial nerve stimulation for enhanced postoperative recovery after colorectal surgery: a double-blind, parallel-group, randomized controlled trial. 61
33001324 2021
20
Hepatic portal venous gas and combined colchicine-bortezomib toxicity. 61
32619113 2021
21
Clinical characteristics and outcomes of children with WAGR syndrome and Wilms tumor and/or nephroblastomatosis: The 30-year SIOP-RTSG experience. 61
33146894 2021
22
Clinical indicators for the incidence of postoperative ileus after elective surgery for colorectal cancer. 61
33573636 2021
23
[Ischemic Colitis after Closure of Temporary Ileostomy for Low Anterior Resection of Rectal Cancer in a Dialysis Patient-A Case Report]. 61
33597381 2021
24
Readmission and complications after robotic surgery: experience of 10,000 operations at a comprehensive cancer center. 61
32277400 2021
25
Modified intestinal isolation bag as promising tool in promoting bowel resumption after ovarian cancer cytoreductive surgery: a randomized clinical trial. 61
33555430 2021
26
Characteristics and predictors of treatment failure with intravenous tigecycline monotherapy among adult patients with severe Clostridioides (Clostridium) difficile infection: a single-centre observational cohort study. 61
33099134 2021
27
Goal-directed Therapy and Postcystectomy Ileus: Reply. 61
33570599 2021
28
Postoperative ileus: A systematic pathway for radical cystectomy candidates? 61
33556310 2021
29
Relationships between serum electrolyte concentrations and ileus: A joint clinical and mathematical modeling study. 61
33527737 2021
30
Goal-directed Therapy and Postcystectomy Ileus: Comment. 61
33570618 2021
31
Postoperative ileus after laparoscopic primary and incisional abdominal hernia repair with intraperitoneal mesh (DynaMesh®-IPOM versus Parietexâ„¢ Composite): a single institution experience. 61
32504204 2021
32
Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. 61
33368893 2021
33
Goal-directed Therapy and Postcystectomy Ileus: Comment. 61
33570585 2021
34
Efficacy and safety of acupuncture in postoperative ileus after gynecological surgery: A protocol for system review and meta-analysis of randomized controlled trials. 61
33592880 2021
35
Non-invasive vagus nerve stimulation to reduce ileus after major colorectal surgery: Early development study. 61
33539637 2021
36
Meconium-related ileus mimicking ileal atresia in a full-term neonate. 61
33529482 2021
37
Case 2: Abdominal Distention with Paralytic Ileus in a Neonate. 61
33526642 2021
38
Encapsulating peritoneal sclerosis caused by cell-free and concentrated ascites reinfusion therapy: a case report. 61
33546732 2021
39
Clozapine intoxication with severe adverse effects induced by an inflammatory and infectious process: a case report. 61
33550992 2021
40
Management of perforated diverticulitis with generalized peritonitis. A multidisciplinary review and position paper. 61
33155148 2021
41
Complications in patients with neurological impairment after gastrostomy. 61
33560541 2021
42
Comparison of robotic and laparoscopic rectal cancer surgery: a meta-analysis of randomized controlled trials. 61
33536032 2021
43
Extended right colectomy, left colectomy, or segmental left colectomy for splenic flexure carcinomas: a European multicenter propensity score matching analysis. 61
32072288 2021
44
Advanced cervical cancer in young women: imaging study of late and very late radiation-related side effects after successful treatment by combined radiotherapy. 61
33392008 2021
45
Incomplete resection of necrotic bowel may increase mortality in infants with necrotizing enterocolitis. 61
32438367 2021
46
Discrepancy between the survival rate and neuropsychological development in postsurgical extremely low-birth-weight infants: a retrospective study over two decades at a single institution. 61
33427921 2021
47
Uncomplicated Sigmoid Volvulus Is Ideal for Laparoscopic Sigmoidectomy with Transrectal Natural Orifice Specimen Extraction. 61
33496476 2021
48
Impact of obesity on operative complications and outcome after sacrocolpopexy: A systematic review and meta-analysis. 61
33498005 2021
49
Is diversion free ileal pouch-anal anastomosis a safe procedure? A meta-analysis of 4973 cases. 61
33398510 2021
50
The many manifestations of a single disease: neuroborreliosis. 61
33552416 2021
Sources

Variations for Ileus

About this section
Sources

Expression for Ileus

About this section
Search GEO for disease gene expression data for Ileus.
Sources

Pathways for Ileus

About this section

Pathways related to Ileus according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.06 VIP TNF SST OPRM1 MLN IL6
2
Peptide ligand-binding receptors 65
Show member pathways
 13.24 VIP SST OPRM1 MLN GHSR GHRL
3
IL-17 Family Signaling Pathways 64
Show member pathways
 12.24 TNF IL6 IL1B CFTR
5
cAMP signaling pathway 36
12.14 VIP SST GHSR GHRL CFTR
6
Folate Metabolism 1
Show member pathways
 12.1 TNF IL6 IL1B F2 CRP
7
Bacterial infections in CF airways 23
Show member pathways
 12.05 TNF IL6 IL1B CFTR
8
Interleukin-4 and 13 signaling 65
11.81 TNF OPRM1 IL6 IL1B
9
Th1 Differentiation Pathway 64
Show member pathways
 11.68 TNF IL6 IL1B
10
Pertussis 36
11.67 TNF IL6 IL1B
11
Dendritic Cells Developmental Lineage Pathway 64
11.66 TNF IL6 IL1B
12
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.57 TNF IL6 IL1B
13
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.56 TNF SST SLC9A3 IL6 IL1B
14
Legionellosis 36
11.51 TNF IL6 IL1B
15
Malaria 36
11.44 TNF IL6 IL1B
16
Interleukin-10 signaling 65
11.42 TNF IL6 IL1B
17
African trypanosomiasis 36
11.27 TNF IL6 IL1B
18
Lung fibrosis 1
11.26 TNF IL6 IL1B CALCA
19
IL-10 Pathway 63
11.23 TNF IL6 IL1B
20
Development and heterogeneity of the ILC family 1
11.18 TNF IL6 IL1B
21
Antifolate resistance 36
11.14 TNF IL6 IL1B
22
Cytokines and Inflammatory Response 1
11.07 TNF IL6 IL1B
23
Overview of nanoparticle effects 1
10.78 TNF IL6 CRP
24
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.58 TNF IL6 IL1B CALCA
25
Gastric acid production 1
10.43 VIP CCK
Sources

GO Terms for Ileus

About this section

Cellular components related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TNF SST IL6 IL1B GHRL F2
2 perikaryon GO:0043204 9.46 VIP OPRM1 CRH CCK
3 extracellular region GO:0005576 9.44 VIP TNF SST MLN IL6 IL1B

Biological processes related to Ileus according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.06 VIP IL6 IL1B F2 CRH CCK
2 positive regulation of gene expression GO:0010628 9.99 TNF SLC26A9 IL6 IL1B CRP CRH
3 positive regulation of protein phosphorylation GO:0001934 9.96 TNF IL1B F2 CRH
4 cellular response to lipopolysaccharide GO:0071222 9.95 TNF IL6 IL1B GHSR
5 inflammatory response GO:0006954 9.91 TNF IL6 IL1B CRP CRH CALCA
6 chloride transport GO:0006821 9.86 SLC26A9 CLCA1 CFTR
7 regulation of insulin secretion GO:0050796 9.85 TNF IL6 IL1B
8 negative regulation of interleukin-6 production GO:0032715 9.85 TNF GHSR GHRL
9 learning or memory GO:0007611 9.84 VIP GHSR CRH
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 TNF OPRM1 IL1B
11 acute-phase response GO:0006953 9.77 IL6 F2 CRP
12 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.77 GHRL CRH CFTR
13 regulation of sensory perception of pain GO:0051930 9.72 VIP OPRM1 CCK
14 positive regulation of JAK-STAT cascade GO:0046427 9.71 TNF IL6 F2
15 digestion GO:0007586 9.7 SST GUCY2C CCK
16 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
17 negative regulation of appetite GO:0032099 9.68 GHSR CCK
18 adult feeding behavior GO:0008343 9.68 GHSR GHRL
19 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.67 GHSR GHRL
20 negative regulation of norepinephrine secretion GO:0010700 9.67 GHSR CRH
21 positive regulation of interleukin-8 production GO:0032757 9.67 TNF IL6 IL1B CALCA
22 positive regulation of behavioral fear response GO:2000987 9.65 CRH CCK
23 growth hormone secretion GO:0030252 9.65 GHSR GHRL
24 G protein-coupled receptor signaling pathway GO:0007186 9.65 VIP SST OPRM1 MLN GHSR GHRL
25 positive regulation of corticotropin secretion GO:0051461 9.64 GHRL CRH
26 positive regulation of fever generation GO:0031622 9.64 TNF IL1B
27 positive regulation of eating behavior GO:1904000 9.63 GHSR GHRL
28 negative regulation of neurogenesis GO:0050768 9.63 TNF IL6 IL1B
29 regulation of transmission of nerve impulse GO:0051969 9.62 GHSR GHRL
30 positive regulation of cortisol secretion GO:0051464 9.62 GHRL CRH
31 sequestering of triglyceride GO:0030730 9.61 TNF IL1B
32 hormone-mediated apoptotic signaling pathway GO:0008628 9.61 SST CRH
33 regulation of gastric motility GO:1905333 9.58 GHSR GHRL
34 positive regulation of glial cell proliferation GO:0060252 9.58 TNF IL6 IL1B
35 positive regulation of small intestine smooth muscle contraction GO:1904349 9.57 GHSR GHRL
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 TNF IL1B
37 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
38 positive regulation of small intestinal transit GO:0120058 9.49 GHSR GHRL
39 negative regulation of circadian sleep/wake cycle, REM sleep GO:0042322 9.48 GHRL CRH
40 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
41 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
42 positive regulation of appetite GO:0032100 8.8 OPRM1 GHSR GHRL

Molecular functions related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride channel activity GO:0005254 9.33 SLC26A9 CLCA1 CFTR
2 peptide hormone receptor binding GO:0051428 9.26 VIP CCK
3 hormone activity GO:0005179 9.17 VIP SST MLN GHRL CRH CCK
4 neuropeptide hormone activity GO:0005184 9.13 VIP CRH CCK
Sources

Sources for Ileus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....