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ILEUS
MCID: ILS001
MIFTS: 51

Ileus (ILEUS)

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ileus

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MalaCards integrated aliases for Ileus:

Name: Ileus 12 43 15
Ileus of Intestine 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8440
MeSH 43 D045823
NCIt 49 C37979
ICD10 32 K56.7
UMLS 71 C1258215
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Summaries for Ileus

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MalaCards based summary : Ileus, also known as ileus of intestine, is related to meconium ileus and paralytic ileus. An important gene associated with Ileus is GUCY2C (Guanylate Cyclase 2C), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Peppermint and Atracurium have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are homeostasis/metabolism and behavior/neurological

Wikipedia : 74 Ileus is a disruption of the normal propulsive ability of the intestine due to the malfunction of... more...

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Related Diseases for Ileus

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Diseases related to Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 963)
# Related Disease Score Top Affiliating Genes
1 meconium ileus 34.8 SLC9A3 SLC6A14 SLC26A9 GUCY2C CFTR
2 paralytic ileus 34.4 VIP OPRM1 MLN F2 CRP
3 volvulus of midgut 32.4 MLN GUCY2C CRP
4 cystic fibrosis 32.3 VIP TNF SLC9A3 SLC26A9 INS IL6
5 intussusception 32.1 VIP IL6 CRP CFTR
6 peritonitis 31.4 TNF IL6 IL1B F2 CRP
7 cholelithiasis 31.4 SST INS CRP CCK
8 diverticulitis 31.3 TNF IL6 CRP
9 appendicitis 31.3 TNF IL6 IL1B CRP
10 cholecystolithiasis 31.2 SST CRP CCK
11 crohn's disease 31.2 TNF IL6 IL1B CRP
12 intestinal obstruction 31.1 TNF SST SLC26A9 MLN IL6 GUCY2C
13 pneumatosis cystoides intestinalis 31.1 MLN CRP
14 pain agnosia 31.0 OPRM1 IL6 IL1B CCK CALCA
15 intestinal perforation 31.0 TNF IL6 CRP
16 ulcerative colitis 30.7 TNF IL6 IL1B CRP
17 aspiration pneumonia 30.7 IL6 F2 CRP
18 vipoma 30.6 VIP SST CALCA
19 obstructive jaundice 30.6 TNF IL6 F2 CRP
20 lymphadenitis 30.6 TNF MLN IL1B CRP
21 cholangitis 30.6 TNF SST IL6 F2 CRP CFTR
22 perinatal necrotizing enterocolitis 30.6 TNF IL6 IL1B CRP
23 toxic shock syndrome 30.5 TNF IL6 IL1B CRP
24 compartment syndrome 30.5 TNF IL6 F2 CRP
25 gastroenteritis 30.5 TNF MLN IL6 IL1B CRP CALCA
26 abdominal tuberculosis 30.5 TNF F2 CRP
27 exocrine pancreatic insufficiency 30.4 TNF CFTR CCK
28 gastroparesis 30.4 SST MLN GHSR GHRL CCK
29 intestinal disease 30.4 TNF IL6 IL1B GHRL CRP
30 active peptic ulcer disease 30.4 SST F2 CRP
31 pulmonary tuberculosis 30.4 TNF IL6 IL1B CRP
32 thrombophlebitis 30.4 TNF F2 CRP
33 cytomegalovirus infection 30.4 TNF IL6 IL1B
34 amyloidosis 30.4 TNF INS IL6 IL1B CRP
35 gastroschisis 30.4 IL6 IL1B F2
36 aortitis 30.4 TNF IL6 IL1B CRP
37 pulmonary edema 30.3 TNF IL1B F2 CRP CFTR
38 respiratory failure 30.3 TNF IL6 IL1B F2 CRP CFTR
39 pheochromocytoma 30.3 VIP TNF SST MLN IL6 CRH
40 sclerosing cholangitis 30.3 TNF IL6 F2 CFTR
41 endocarditis 30.3 TNF IL6 F2 CRP
42 chickenpox 30.3 TNF IL6 CRP
43 purpura 30.3 TNF IL6 F2 CRP
44 cholangitis, primary sclerosing 30.3 TNF IL6 F2 CFTR
45 disseminated intravascular coagulation 30.3 TNF IL6 F2 CRP
46 gallbladder disease 30.3 SST MLN INS CRP CFTR CCK
47 eclampsia 30.2 TNF IL6 F2
48 peptic ulcer disease 30.2 TNF SST INS IL1B GHRL
49 poems syndrome 30.2 TNF IL6 IL1B
50 newborn respiratory distress syndrome 30.2 IL6 IL1B CRP

Graphical network of the top 20 diseases related to Ileus:



Diseases related to Ileus
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Symptoms & Phenotypes for Ileus

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MGI Mouse Phenotypes related to Ileus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 CCK CFTR CRH CRP F2 GHRL
2 behavior/neurological MP:0005386 10.21 CFTR CRH F2 GHRL GHSR GUCY2C
3 digestive/alimentary MP:0005381 10.18 CFTR F2 GHRL GHSR GUCY2C IL6
4 endocrine/exocrine gland MP:0005379 10.15 CCK CFTR CRH GHRL IL6 INS
5 adipose tissue MP:0005375 10.11 CRH GHRL GHSR GUCY2C IL6 INS
6 immune system MP:0005387 10.07 CFTR CRH CRP F2 GUCY2C IL1B
7 integument MP:0010771 9.81 CRH F2 GUCY2C IL1B IL6 INS
8 no phenotypic analysis MP:0003012 9.56 CCK CFTR CRH GHSR INS OPRM1
9 normal MP:0002873 9.28 CFTR CRH F2 GHRL INS OPRM1
Sources

Drugs & Therapeutics for Ileus

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Drugs for Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 291)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Peppermint Approved Phase 4
2
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
3
Orphenadrine Approved Phase 4 83-98-7 4601
4
Histamine Approved, Investigational Phase 4 51-45-6 774
5
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
6
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
7
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
8
Succinylcholine Approved Phase 4 306-40-1 5314
9
Povidone-iodine Approved Phase 4 25655-41-8
10
Loperamide Approved Phase 4 53179-11-6 3955
11
Bisacodyl Approved Phase 4 603-50-9
12
Bismuth subsalicylate Approved, Vet_approved Phase 4 14882-18-9 53629521
13
Dimenhydrinate Approved Phase 4 523-87-5 441281
14
Simethicone Approved Phase 4 8050-81-5
15
Sorbitol Approved Phase 4 50-70-4 5780
16
tannic acid Approved Phase 4 1401-55-4
17
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
18
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
19
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
20
Clonidine Approved Phase 4 4205-90-7 2803
21
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
22
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
23
Labetalol Approved Phase 4 36894-69-6 3869
24 Hydrotalcite Approved, Experimental, Investigational Phase 4 12304-65-3
25
Sucralfate Approved Phase 4 54182-58-0
26
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
27
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
28
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
29
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
30
Remifentanil Approved Phase 4 132875-61-7 60815
31
Ondansetron Approved Phase 4 99614-02-5 4595
32
Scopolamine Approved, Investigational Phase 4 6533-68-2, 51-34-3 5184
33
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
34
Cyclobenzaprine Approved Phase 4 303-53-7 2895
35
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
36
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
37
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
38
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
39
Tapentadol Approved Phase 4 175591-23-8 9838022
40
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
41
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
42
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
43
Alvimopan Approved, Investigational Phase 4 156053-89-3 5488548
44
Morphine Approved, Investigational Phase 4 57-27-2 5288826
45
Nicotine Approved Phase 4 54-11-5 942 89594
46
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
47
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
48
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
49
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
50
Acetaminophen Approved Phase 4 103-90-2 1983

Interventional clinical trials:

(show top 50) (show all 403)
# Name Status NCT ID Phase Drugs
1 Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus Unknown status NCT02425774 Phase 4 Prucalopride;Placebo
2 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4 gum
3 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Unknown status NCT02056405 Phase 4 Mosapride;Placebo
4 Effect of Intravenous Lidocaine on Postoperative Pain Management After Laparoscopy Cholecystectomy Unknown status NCT02997215 Phase 4 Lidocaine;Saline Placebo
5 Usefulness Of Flospan As A Premedication For Colonoscopy : A Randomized Double Blind Controlled Trial Unknown status NCT01842932 Phase 4 Phloroglucin;Cimetropium bromide;Placebo
6 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
7 Comparative Randomized Controlled Trial Study of General Balanced Anesthesia Based on Opioid and Opioid Sparing Balanced Anesthesia for Cholecystectomy Surgery Via Laparoscopy: Intraoperative and Postoperative Outcomes Unknown status NCT02953210 Phase 4 dexter ketamine;Lidocaine Hydrochloride;Fentanyl Hydrochloride;Clonidine Hydrochloride;Midazolam Hydrochloride;Isoflurane Volatile Liquid;Rocuronium Injectable Solution;Propofol 1 % Injectable Suspension;Dexamethasone-21-Sulfobenzoate, Sodium Salt;Ranitidine Hydrochloride;Ondansetron Hydrochloride;Ketorolac Injectable Solution;Bupivacaine Hydrochloride
8 NK Activity Modulation by Intravenous Lidocaine During Laparoscopic Colorectal Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
9 Randomised Study to Compare the Regain of Gastrointestinal Motility After General Anaesthesia Versus Spinal Anaesthesia in Caesarean Section.Kasr El Ainy,Egypt Experience Unknown status NCT02504749 Phase 4
10 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
11 COLITIS: Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
12 Prospective Randomized Double Blind Study of the Effect of Gastrografin on Postoperative Ileus After Colorectal Surgery Completed NCT01440712 Phase 4 Gastrografin;physiological serum
13 A Phase 4, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Postoperative Ileus in Subjects Undergoing Radical Cystectomy. Completed NCT00708201 Phase 4 Alvimopan;Placebo
14 A New Approach of Neostigmine in Unavoidable Post Operative Ileus After Surgery Completed NCT00676377 Phase 4 Neostigmine;Saline
15 A Randomized Controlled Trial of the Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery: A Pilot Study Completed NCT02161367 Phase 4 Simethicone;Oral Suspending Vehicle
16 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4 Magnesia;Placebo
17 Preoperative Bowel Preparation Versus no Preparation Before Spinal Surgery: a Randomised Clinical Trial Completed NCT01879605 Phase 4 Docusate natrium and sorbitol;Bisacodyl
18 Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery Completed NCT00509327 Phase 4 bisacodyl;glucosemonohydricum
19 Influence of Epidural Analgesia in Elective Laparoscopic Colorectal Resections Completed NCT00512395 Phase 4 epidural analgesia (Duracain/Fentanyl/Naropin)
20 Postoperative Analgesic Effects of Dexmedetomidine Added to Bupivacaine for Transversus Abdominis Plane Block for Lower Abdominal Surgery Completed NCT02064530 Phase 4 Bupivacaine;Dexmedetomidine;serum physiologic
21 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants- a Phase 4 Study Completed NCT01515696 Phase 4 Gastrografin;Sterile water
22 Opioid Free Anesthesia: What About Patient Comfort? Completed NCT02882035 Phase 4
23 Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease: A Prospective Randomized Single-Blind Trial Completed NCT00453830 Phase 4
24 Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial Completed NCT02363699 Phase 4 Lidocaine;Saline solution
25 The Impact of Visceral Osteopathic Treatment on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT02140710 Phase 4
26 Laparoscope Subtotal Colectomy With Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation Completed NCT02147574 Phase 4
27 Estimation of the Effect of Intravenous Lidocaine on BIS-guided Propofol Requirements During General Anesthesia Completed NCT01366300 Phase 4 Intravenous lidocaine infusion;Propofol 1% (intravenous infusion)
28 Surgical Pain Control With Ropivacaine by Atomized Delivery Completed NCT01480089 Phase 4 Intraperitoneal Ropivacaine (AIR);Atomized Intraperitoneal Saline (AIS)
29 A Randomized Clinical Study of the Efficacy of a Formulation of Four Probiotics for the Prevention of Post-operative Complications in Patients Undergoing Colorectal Surgery Completed NCT02313519 Phase 4
30 Randomized, Double-Blinded, Active-Controlled Study to Evaluate the Intraoperative Use of Labetalol vs. Esmolol for Maintaining Hemodynamic Stability During Laparoscopic Surgery: Effect on Recovery and Postoperative Pain Completed NCT01114971 Phase 4 Fentanyl;Labetalol;Esmolol
31 A Randomized Comparison of Concomitant Incontinence Procedures Performed With Abdominal Sacral Colpopexy: the Burch Versus Mid-urethral Sling Trial Completed NCT00934999 Phase 4
32 Impact of the Serratus Plane Block in Pain and the Use of Opioids in Breast Completed NCT02905149 Phase 4
33 A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment: Randomized Trial Completed NCT03635372 Phase 4 Alginate;Sucralfate;Hydrotalcite
34 Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty Completed NCT02601651 Phase 4 Lidocaine;Normal saline
35 Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial Completed NCT00318825 Phase 4 Nitrous oxide
36 Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia: Randomized Clinical Trial Completed NCT01778387 Phase 4
37 A Simple Oral Nutrition Protocol Reduces Length of Stay in Patients With Regular Radical Cystectomy Completed NCT01777126 Phase 4
38 Assessing the Safety of a Continuous Potassium Chloride Infusion in Critical Care: A Randomised Controlled Trial Completed NCT00718068 Phase 4 Sterile Potassium Chloride Concentrate;Sterile Potassium Chloride Concentrate
39 Adjuvant Analgesic Effects of Low Dose Tramadol/Acetaminophen Combination After Open Gynaecological Surgery Completed NCT00942565 Phase 4 tramadol/acetaminophen;acetaminophen
40 Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
41 PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation: A Randomised Controlled Study Completed NCT01788709 Phase 4
42 The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus Recruiting NCT03176316 Phase 4 Naloxone
43 Efficacy of the Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures Recruiting NCT02805504 Phase 4 Exparel;Marcaine
44 Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial Recruiting NCT04017013 Phase 4 Lidocaine Infusion
45 Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study Recruiting NCT02202369 Phase 4
46 Impact of the Administration of Intravenous or Paravertebral Lidocaine in Continuous Perfusion During the Intraoperative Period of Lung Resection Surgery on the Appearance of Postoperative Complications Recruiting NCT03905837 Phase 4 Lidocaine;Remifentanil
47 The Impact of the Continuous Infusion of Intraperitoneal Analgesics on Postoperative Pain After Minimally Invasive Hysterectomy: a Randomized Controlled Trial Recruiting NCT04130464 Phase 4 Ropivacaine Infusion from ON-Q Pump;Ropivacaine + Ketorolac Infusion from ON-Q Pump;Normal Saline Infusion from ON-Q Pump
48 A Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial Evaluating the Use of Perioperative Intravenous Lidocaine Infusion to Decrease Pain Scores and Opioid Consumption After Robotic-Assisted Prostatectomy and Robotic-Assisted Partial Nephrectomy Recruiting NCT03824808 Phase 4 Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution;0.9% Sodium Chloride Injection
49 A Prospective, Double-blind, Randomized, and Controlled Clinical Trial to Compare the Effectiveness of Intravenous Bezlotoxumab (10 mg/kg) Versus Placebo in Decreasing Morbidity and Mortality in Patients With Fulminant Clostridioides Difficile Requiring Surgical Intervention. Recruiting NCT03756454 Phase 4
50 Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Unilateral Total Knee Arthroplasty- A Randomised, Double Blind, Active Control, Clinical Trial Recruiting NCT03604354 Phase 4 Tapentadol 100 MG Oral Tablet;Pregabalin 150mg

Search NIH Clinical Center for Ileus

Cochrane evidence based reviews: ileus

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Genetic Tests for Ileus

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Anatomical Context for Ileus

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MalaCards organs/tissues related to Ileus:

40
Colon, Small Intestine, Liver, Lung, Kidney, Pancreas, Lymph Node
Sources

Publications for Ileus

About this section

Articles related to Ileus:

(show top 50) (show all 11521)
# Title Authors PMID Year
1
Ultrarestrictive intraoperative intravenous fluids during pancreatoduodenectomy is not associated with an increase in post-operative acute kidney injury. 61
32234242 2020
2
Ultrasound-Guided Transversus Abdominis Plane Block in Shetland Ponies: A Description of a Three-Point Injection Technique and Evaluation of Potential Analgesic Effects. 61
32534772 2020
3
Gastroepiploic Lymph Node Flap Harvest for Patients With Lymphedema: Minimally Invasive Versus Open Approach. 61
32530851 2020
4
Association of Frailty with Delayed Recovery of Gastrointestinal Function after Elective Colorectal Cancer Resections. 61
30430890 2020
5
Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction. 61
32464544 2020
6
Strongyloides stercoralis hyperinfection syndrome presenting as mechanical ileus after short-course oral steroids for chronic obstructive pulmonary disease (COPD) exacerbation. 61
32087332 2020
7
Paralytic ileus after planned abdominal surgery in a patient on treatment with erenumab. 61
32557089 2020
8
Effect of Opiate Use on Prolonged Postoperative Ileus: a Prospective Cohort Study. 61
32495138 2020
9
Efficacy of prucalopride in critically ill patients with paralytic ileus: A pilot randomized double-blind placebo-controlled trial. 61
32483847 2020
10
Perioperative Outcomes of Open Retrograde Extraperitoneal Versus Intracorporeal Robot-assisted Radical Cystoprostatectomy in Men: A Dual-center Comparative Study. 61
31911120 2020
11
Anterior lumbar compared to oblique lumbar interbody approaches for multilevel fusions to the sacrum in adults with spinal deformity and degeneration. 61
32534496 2020
12
Role of high-dose salvage radiotherapy for oligometastases of the localised abdominal/pelvic lymph nodes: a retrospective study. 61
32517673 2020
13
Dual-Energy CT of Gallstone Ileus. 61
32096710 2020
14
Tamrintamab pamozirine (SC-003) in patients with platinum-resistant/refractory ovarian cancer: Findings of a phase 1 study. 61
32513564 2020
15
iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation. 61
32373648 2020
16
Totally robotic right hemicolectomy: a multicentre case-matched technical and peri-operative comparison of port placements and da Vinci models. 61
31468314 2020
17
How the Beneficial Effects of Alvimopan Differ With Surgical Approach for Radical Cystectomy. 61
32113791 2020
18
Enhanced recovery after surgery in emergency resection for obstructive colorectal cancer: a systematic review and meta-analysis. 61
32572602 2020
19
The Feasibility of Outpatient Revision Total Knee Arthroplasty in Selected Case Scenarios. 61
32139191 2020
20
Evaluation of laparoscopic surgery for small bowel obstruction and factors related to outcomes. 61
32489486 2020
21
Electrocolonography: Non-Invasive Detection of Colonic Cyclic Motor Activity From Multielectrode Body Surface Recordings. 61
31535980 2020
22
L-Arginine/NO Pathway Metabolites in Colorectal Cancer: Relevance as Disease Biomarkers and Predictors of Adverse Clinical Outcomes Following Surgery. 61
32521714 2020
23
Colorectal Surgical Site Infection Prevention Kits Prior to Elective Colectomy Improve Outcomes. 61
30688687 2020
24
Endogenous Endophthalmitis successfully treated with Intravitreal Povidone-iodine injection: a case report. 61
32503467 2020
25
Minimally Invasive Surgery Oblique Lumbar Interbody Debridement and Fusion for the Treatment of Lumbar Spondylodiscitis. 61
32524753 2020
26
Constipation screening in people taking clozapine: A diagnostic accuracy study. 61
32245597 2020
27
[Impact of bowel preparation on surgical site infections and anastomotic leakage after elective colon resection: results of a retrospective study with 260 patients]. 61
31915873 2020
28
Alvimopan Is Associated With a Reduction in Length of Stay and Hospital Costs for Patients Undergoing Radical Cystectomy. 61
32268172 2020
29
[Abdominal imaging in cystic fibrosis]. 61
32495009 2020
30
Effectiveness of jejunostomy for enteral nutrition during complete thoracoscopic and laparoscopic Ivor-Lewis esophagectomy in thoracic segment esophageal carcinoma. 61
32552786 2020
31
Two-stage Reconstruction Using a Free Jejunum/Ileum Flap After Total Esophagectomy. 61
32501843 2020
32
Mast Cell Tryptase Promotes Inflammatory Bowel Disease-Induced Intestinal Fibrosis. 61
32507895 2020
33
Long term clinical outcome of cystic fibrosis pediatric patients presenting with meconium ileus. 61
32512617 2020
34
Diagnostic performance and role of the contrast enema for low intestinal obstruction in neonates. 61
32572600 2020
35
Ileus caused by small bowel, ileocaecal and rectal endometriosis misdiagnosed as Crohn's disease and managed by synchronous ileocaecal and rectal resection. 61
32538117 2020
36
Early Postoperative Small Bowel Obstruction After Appendectomy Because of Staples in Pediatric Patients. 61
32505924 2020
37
Three-Field versus Two-Field Lymphadenectomy for Esophageal Squamous Cell Carcinoma: A Meta-Analysis. 61
32563760 2020
38
Gastrointestinal Complications After Cardiac Surgery: Highly Morbid but Improving Over Time. 61
32504971 2020
39
Meta-analysis and trial sequential analysis of robotic versus laparoscopic total mesorectal excision in management of rectal cancer. 61
32556460 2020
40
Outcomes of urinary diversion after surgery for locally advanced or locally recurrent rectal cancer with complete cystectomy; ileal and colon conduit. 61
32122756 2020
41
Multivisceral robotic liver surgery: feasible and safe. 61
31489535 2020
42
First case of paralytic ileus after endoscopic mucosal resection of caecal polyp. 61
32423855 2020
43
Rare recurrent gallstone ileus: A case report. 61
32518796 2020
44
Dapagliflozin-associated euglycemic diabetic ketoacidosis in a patient with type 2 diabetes mellitus: A case report. 61
32481295 2020
45
WJOG10517G: a multicenter Phase II study of mFOLFOX6 in gastric cancer patients with severe peritoneal metastases. 61
32466683 2020
46
Neonatal screening programme for CF: Results from the Irish Comparative Outcomes Study (ICOS). 61
32470170 2020
47
Immunohistochemical study of morphology and distribution of CD163+ve macrophages in the normal adult equine gastrointestinal tract. 61
32559524 2020
48
Gastrointestinal Complications After Pancreatoduodenectomy With Epidural vs Patient-Controlled Intravenous Analgesia: A Randomized Clinical Trial. 61
32459322 2020
49
Comparison Study of Patient Demographics, Risk Factors, and Lengths of Stay for Postoperative Ileus After Primary Total Knee Arthroplasty. 61
31866253 2020
50
[Acute abdomen with Bilious Vomiting - A Linseed Bezoar as a Rare Cause of an Obstructive Ileus in an Anorexic Adolescent]. 61
32455437 2020
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Variations for Ileus

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Expression for Ileus

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Search GEO for disease gene expression data for Ileus.
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Pathways for Ileus

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Pathways related to Ileus according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14 VIP TNF SST OPRM1 MLN INS
2
Peptide ligand-binding receptors 65
Show member pathways
 13.3 VIP SST OPRM1 MLN GHSR GHRL
3
IL-17 Family Signaling Pathways 64
Show member pathways
 12.25 TNF IL6 IL1B CFTR
5
Pathogenic Escherichia coli infection 36
12.18 TNF IL6 IL1B F2
6
cAMP signaling pathway 36
12.17 VIP SST GHSR GHRL CFTR
7
Bacterial infections in CF airways 22
Show member pathways
 12.08 TNF IL6 IL1B CFTR
8
Interleukin-4 and 13 signaling 65
11.85 TNF OPRM1 IL6 IL1B
9
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.76 TNF SST SLC9A3 IL6 IL1B
10
Pertussis 36
11.68 TNF IL6 IL1B
11
Dendritic Cells Developmental Lineage Pathway 64
11.67 TNF IL6 IL1B
12
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 TNF IL6 IL1B
13
Legionellosis 36
11.52 TNF IL6 IL1B
14
Malaria 36
11.45 TNF IL6 IL1B
15
Interleukin-10 signaling 65
11.43 TNF IL6 IL1B
16
Folate Metabolism 1
Show member pathways
 11.43 TNF INS IL6 IL1B F2 CRP
17
Lung fibrosis 1
11.36 TNF IL6 IL1B CALCA
18
African trypanosomiasis 36
11.29 TNF IL6 IL1B
19
IL-10 Pathway 63
11.26 TNF IL6 IL1B
20
Development and heterogeneity of the ILC family 1
11.21 TNF IL6 IL1B
21
Antifolate resistance 36
11.18 TNF IL6 IL1B
22
Cytokines and Inflammatory Response 1
11.12 TNF IL6 IL1B
23
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.91 TNF IL6 IL1B CALCA
24
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.88 INS GHSR GHRL
25
Overview of nanoparticle effects 1
10.82 TNF IL6 CRP
26
Gastric acid production 1
10.44 VIP CCK
Sources

GO Terms for Ileus

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Cellular components related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TNF SST INS IL6 IL1B GHRL
2 perikaryon GO:0043204 9.46 VIP OPRM1 CRH CCK
3 extracellular region GO:0005576 9.44 VIP TNF SST MLN INS IL6

Biological processes related to Ileus according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.19 VIP OPRM1 INS IL6 IL1B GUCY2C
2 cellular protein metabolic process GO:0044267 9.99 INS IL6 F2 CALCA
3 positive regulation of protein phosphorylation GO:0001934 9.97 TNF IL1B F2 CRH
4 cellular response to lipopolysaccharide GO:0071222 9.96 TNF IL6 IL1B GHSR
5 positive regulation of cell proliferation GO:0008284 9.95 VIP INS IL6 IL1B F2 CRH
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 TNF INS IL6 IL1B
7 inflammatory response GO:0006954 9.93 TNF IL6 IL1B CRP CRH CALCA
8 learning or memory GO:0007611 9.86 VIP GHSR CRH
9 glucose metabolic process GO:0006006 9.85 TNF INS GHRL
10 positive regulation of interleukin-6 production GO:0032755 9.84 TNF IL6 IL1B
11 positive regulation of gene expression GO:0010628 9.8 TNF SLC26A9 INS IL6 IL1B CRP
12 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.77 GHRL CRH CFTR
13 regulation of sensory perception of pain GO:0051930 9.76 VIP OPRM1 CCK
14 positive regulation of JAK-STAT cascade GO:0046427 9.75 TNF IL6 F2
15 digestion GO:0007586 9.74 SST GUCY2C CCK
16 positive regulation of interleukin-8 production GO:0032757 9.73 TNF IL1B CALCA
17 negative regulation of neurogenesis GO:0050768 9.72 TNF IL6 IL1B
18 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.7 GHSR GHRL
19 negative regulation of blood vessel diameter GO:0097756 9.69 INS CRP
20 negative regulation of appetite GO:0032099 9.69 GHSR CCK
21 positive regulation of blood vessel diameter GO:0097755 9.69 VIP INS CALCA
22 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.68 GHSR GHRL
23 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
24 negative regulation of norepinephrine secretion GO:0010700 9.68 GHSR CRH
25 positive regulation of behavioral fear response GO:2000987 9.67 CRH CCK
26 growth hormone secretion GO:0030252 9.65 GHSR GHRL
27 positive regulation of corticotropin secretion GO:0051461 9.65 GHRL CRH
28 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
29 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
30 hormone-mediated apoptotic signaling pathway GO:0008628 9.64 SST CRH
31 positive regulation of eating behavior GO:1904000 9.63 GHSR GHRL
32 regulation of transmission of nerve impulse GO:0051969 9.63 GHSR GHRL
33 positive regulation of cortisol secretion GO:0051464 9.62 GHRL CRH
34 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
35 regulation of gastric motility GO:1905333 9.61 GHSR GHRL
36 positive regulation of small intestine smooth muscle contraction GO:1904349 9.61 GHSR GHRL
37 negative regulation of lipid catabolic process GO:0050995 9.61 TNF INS IL1B
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 TNF IL1B
39 positive regulation of small intestinal transit GO:0120058 9.54 GHSR GHRL
40 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B
41 negative regulation of circadian sleep/wake cycle, REM sleep GO:0042322 9.52 GHRL CRH
42 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
43 acute-phase response GO:0006953 9.46 INS IL6 F2 CRP
44 G protein-coupled receptor signaling pathway GO:0007186 9.36 VIP SST OPRM1 MLN INS GHSR
45 positive regulation of appetite GO:0032100 9.13 OPRM1 GHSR GHRL

Molecular functions related to Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 VIP SST MLN INS GHRL CRH
2 peptide hormone receptor binding GO:0051428 9.16 VIP CCK
3 neuropeptide hormone activity GO:0005184 9.13 VIP CRH CCK
Sources

Sources for Ileus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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