Immature Cataract disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A senile cataract that is characterized by variable opacification of the lens of the eye with some clear lens fibers remaining.

MalaCards based summary: Immature Cataract, also known as incipient senile cataract, is related to presbyopia and senile cataract. An important gene associated with Immature Cataract is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways is O2/CO2 exchange in erythrocytes. Affiliated tissues include eye and endothelial, and related phenotype is Increased shRNA abundance (Z-score > 2).

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Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)

#	Related Disease	Score	Top Affiliating Genes
1	presbyopia	29.8	CRYGS CRYGB CRYBB2 CRYAA
2	senile cataract	29.7	CRYGS CRYGB CRYBB2 CRYAA
3	cataract	29.2	DMPK CRYGS CRYGB CRYBB2 CRYAA COL4A4
4	phacolytic glaucoma	11.1
5	morgagni cataract	10.2	CRYGS CRYAA
6	cataract microcornea syndrome	10.2	CRYBB2 CRYAA
7	retinal perforation	10.2	CRYGS CRYAA
8	early-onset sutural cataract	10.2	CRYGS CRYBB2
9	axenfeld-rieger syndrome, type 3	10.2	CRYGS CRYAA
10	early-onset nuclear cataract	10.2	CRYBB2 CRYAA
11	axenfeld-rieger syndrome	10.2	CRYGS CRYAA
12	galactosemia ii	10.2	CRYGS CRYAA
13	cataract 9, multiple types	10.2	CRYBB2 CRYAA
14	coloboma of optic nerve	10.2	CRYGS CRYAA
15	persistent hyperplastic primary vitreous	10.2	CRYGS CRYAA
16	brain small vessel disease	10.2	CRYAA COL4A4
17	cataract 24	10.1	CRYGB CRYAA
18	night blindness, congenital stationary, type 2a	10.1	CRYGB CRYAA
19	porencephaly	10.1	CRYAA COL4A4
20	cataract 48	10.1	CRYGB CRYAA
21	cataract 18	10.1	CRYGB CRYAA
22	abruzzo-erickson syndrome	10.1	CRYGB CRYAA
23	nuclear senile cataract	10.1	CRYGS CRYGB
24	papillorenal syndrome	10.1	CRYAA COL4A4
25	mature cataract	10.1	CRYGS CRYBB2 CRYAA
26	amblyopia	10.1	CRYGS CRYBB2 CRYAA
27	posterior polar cataract	10.1	CRYGS CRYBB2 CRYAA
28	nance-horan syndrome	10.1	CRYGS CRYBB2 CRYAA
29	aniridia 1	10.1	CRYGS CRYBB2 CRYAA
30	x-linked hereditary ataxia	10.0	DMPK CNBP
31	myotonia	10.0	DMPK CNBP
32	myotonic disease	10.0	DMPK CNBP
33	huntington disease-like 2	10.0	DMPK CNBP
34	early-onset lamellar cataract	10.0	CRYGS CRYGB CRYAA
35	deprivation amblyopia	10.0	CRYGS CRYGB CRYAA
36	eye accommodation disease	10.0	CRYGS CRYGB CRYAA
37	diabetic cataract	10.0	CRYGS CRYGB CRYAA
38	myotonic dystrophy 2	10.0	DMPK CNBP
39	myotonia congenita	10.0	DMPK CNBP
40	congenital aphakia	10.0	CRYGB CRYBB2 CRYAA
41	cataract 44	10.0	CRYGB CRYBB2 CRYAA
42	fragile x-associated tremor/ataxia syndrome	9.9	DMPK CNBP
43	spinal and bulbar muscular atrophy, x-linked 1	9.9	DMPK CRYAA CNBP
44	muscle tissue disease	9.9	DMPK CRYAA CNBP
45	muscular disease	9.9	DMPK CRYAA CNBP
46	autosomal dominant cerebellar ataxia	9.9	DMPK CRYAA CNBP
47	myopia	9.8
48	fuchs' endothelial dystrophy	9.8	DMPK COL4A4 CNBP
49	glutathione peroxidase deficiency	9.8	HBA2 HBA1
50	type 1 diabetes mellitus 24	9.8	HBA2 HBA1

Graphical network of the top 20 diseases related to Immature Cataract:

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Symptoms & Phenotypes for Immature Cataract

GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

²⁵ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-103	9.78	CRYBB2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-111	9.78	GTPBP1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	9.78	HBA1 HBA2
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.78	GTPBP1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-136	9.78	CRYBB2
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	9.78	HBA1 HBA2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-148	9.78	GTPBP1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.78	GTPBP1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-181	9.78	HBA1 HBA2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.78	CRYBB2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	9.78	GTPBP1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-48	9.78	GTPBP1 HBA1 HBA2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-5	9.78	CRYBB2
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.78	GTPBP1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-69	9.78	CRYBB2
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.78	CRYBB2
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-97	9.78	CRYBB2

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Drugs & Therapeutics for Immature Cataract

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Outcomes of Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification	Completed	NCT02561104

Search NIH Clinical Center for Immature Cataract

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Genetic Tests for Immature Cataract

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Anatomical Context for Immature Cataract

Organs/tissues related to Immature Cataract:

MalaCards : Eye, Endothelial

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Publications for Immature Cataract

Articles related to Immature Cataract:

(show top 50) (show all 109)

#	Title	Authors	PMID	Year
1	Ophthalmic Parameters and Ophthalmoscopy of Burrowing Owls (Athene cunicularia). ⁶²	Bennett K...Sadar MJ	35972872	2022
2	Effect of oral antioxidants on the progression of canine senile cataracts: a retrospective study. ⁶²	Park S...Seo K	35466599	2022
3	Phacoemulsification and intraocular lens implantation in a Canada lynx with phacoclastic uveitis. ⁶²	Lavallee G...Sandmeyer LS	35237016	2022
4	[Evaluation of aqueous cytokine levels in eyes with Fuchs endothelial corneal dystrophy and bullous keratopathy]. ⁶²	Fisenko NV...Subbot AM	34156773	2021
5	A clinical study to assess feasibility, acceptance, and outcome of multifocal intraocular lens in patients with bilateral immature cataract at a tertiary eye care institute. ⁶²	Deshpande R...Sanghavi N	33120631	2020
6	Social impact indicators in patient diagnosed of senile cataract treated with phacoemulsification plus intraocular lens implantation. ⁶²	Onofre-Deciga PK...Perez-Cano H	32538985	2020
7	The protein-water nuclear Overhauser effect (NOE) as an indirect microscope for molecular surface mapping of interaction patterns. ⁶²	Honegger P...Steinhauser O	31799520	2019
8	Ophthalmic examination findings and intraocular pressures in wild-caught African giant pouched rats (Cricetomys spp.). ⁶²	Heller AR...Ophir AG	29251400	2018
9	Volumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomography. ⁶²	Grulkowski I...Artal P	30338158	2018
10	Comparative Study of Extra Capsular Cataract Extraction (ECCE) and Small Incision Cataract Surgery (SICS): Experience on Cataract Surgery in a Tertiary Center of Army Hospital, Kathmandu. ⁶²	Rajkarnikar S...Gurung A	31056560	2018
11	Rapid macular hole formation and closure in a vitrectomized eye following rhegmatogenous retinal detachment repair. ⁶²	Ranjan R...Narendran V	29563703	2018
12	Microsporidial infection masquerading as graft rejection post-Descemet's stripping automated endothelial keratoplasty. ⁶²	Devi L...Das M	28905834	2017
13	Intracameral mydriatics versus topical mydriatics in pupil dilation for phacoemulsification cataract surgery. ⁶²	Lay Suan AL...Mansurali VN	28917402	2017
14	Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients. ⁶²	Nagai N...Sasaki H	28666280	2017
15	Anterior lens epithelium in cataract patients with retinitis pigmentosa - scanning and transmission electron microscopy study. ⁶²	Andjelic S...Hawlina M	27679403	2017
16	Modified penetrating keratoplasty with Acell® bioscaffold implant in seven horses with deep full-thickness corneal stromal abscess. ⁶²	Cichocki BM...Moore PA	26840652	2017
17	[The concentration of cerebral natriuretic peptide in tear and blood serum.] ⁶²	Sosnin DY...Chereshneva MV	30856302	2017
18	Marathoning with myotonic dystrophy type 2 (proximal myotonic myopathy) and leukopenia. ⁶²	Finsterer J...Witsch-Baumgartner M	28491317	2017
19	A case of keratitis associated with limbal relaxing incision. ⁶²	Haripriya A...Smita A	28112139	2016
20	Phacoantigenic Reaction Masquerading as Postoperative Endophthalmitis in a Silicone Oil-filled Eye. ⁶²	Rajesh B...Giridhar A	27994397	2016
21	Central corneal thickness changes in bevel-up versus bevel-down phacoemulsification cataract surgery: study protocol for a randomised, triple-blind, parallel group trial. ⁶²	Kaup S...Varghese RC	27687899	2016
22	[Intraocular pressure measurement inside the anterior chamber: a new technical solution and results]. ⁶²	Avetisov SE...Avetisov KS	28121293	2016
23	Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). ⁶²	Bhati H...Manjusha R	27313415	2015
24	Manuel's asteroid disruption technique. ⁶²	John M...Jacob I	23571244	2015
25	Treatment of congenital aniridia associated with subluxated infantile cataract. ⁶²	Jusufovic V...Zvornicanin J	25568537	2014
26	Treatment of congenital aniridia associated with subluxated infantile cataract. ⁶²	Jusufovic V...Zvornicanin J	25195356	2014
27	Corneal edema after phacoemulsification surgery in patients with type II diabetes mellitus. ⁶²	Shakya K...Malla OK	24172560	2013
28	Objective assessment of crystalline lens opacity level by measuring ocular light scattering with a double-pass system. ⁶²	Cabot F...Gatinel D	23317652	2013
29	Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. ⁶²	Oksuz H...Taskin I	24303209	2013
30	Cataract surgery after Descemet stripping endothelial keratoplasty. ⁶²	Chaurasia S...Sangwan V	23202404	2012
31	Tolerability and pharmacokinetics of intravitreal sirolimus. ⁶²	Mudumba S...Naor J	22662868	2012
32	[Reduced glutathione level and GSH-dependent enzyme activities in corticonuclear blocks of lenses in patients with senile cataract]. ⁶²	Kisic B...Dragojevic I	23289270	2012
33	Antioxidant capacity of lenses with age-related cataract. ⁶²	Kisic B...Dragojevic I	22363833	2012
34	Septic lens implantation syndrome in a cat. ⁶²	Dalesandro N...Miller M	21923828	2011
35	Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f rat. ⁶²	Floyd KA...Barnes S	21147102	2011
36	[Biometry of anterior segment structures: comparative study]. ⁶²	Avetisov KS...Bubnova IA	21394995	2010
37	[Treatment of fungal keratitis by penetrating keratoplasty]. ⁶²	Imtirat A...Lifshitz T	20684168	2010
38	Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? ⁶²	Singh SK...Surin L	21141000	2009
39	[Phacoemulsification in eyes with white cataracts: results and complications]. ⁶²	Guigui B...Chaine G	18046274	2007
40	Pattern of eye diseases and visual impairment among students in southwestern Nigeria. ⁶²	Ajaiyeoba AI...Oluleye TS	17585376	2007
41	Management of bilateral uveitis in a Toxoplasma gondii-seropositive cat with histopathologic evidence of fungal panuveitis. ⁶²	Pearce J...Moore CP	17565553	2007
42	The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study. ⁶²	Williams DL...Munday P	16939459	2006
43	[Optic coherent tomography in patients with immature cataract and pseudophakia]. ⁶²	Shpak AA...Dorokhova MIu	16927778	2006
44	Biochemical researches in age related cataract. ⁶²	Nechita A...Nechita N	16927758	2006
45	Prevalence and causes of blindness and visual impairment among school children in south-western Nigeria. ⁶²	Ajaiyeoba AI...Oluleye TS	17200795	2005
46	[Multifocal phakic intraocular lens implant to correct presbyopia]. ⁶²	Baikoff G...Spera C	15883490	2005
47	Surgical strategies in patients with cataract and glaucoma. ⁶²	Verges C...Lavin C	15650579	2005
48	Incidence of and risk factors for residual posterior capsule opacification after cataract surgery. ⁶²	Mootha VV...Qualls C	15519088	2004
49	Excessive maternal caffeine exposure during pregnancy is cataractogenic for neonatal crystalline lenses in rats: a biomicroscopic and histopathologic study. ⁶²	Evereklioglu C...Pirbudak L	15453852	2004
50	Lens morphometry determined by B-mode ultrasonography of the normal and cataractous canine lens. ⁶²	Williams DL	14982588	2004

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Genes for Immature Cataract

Genes related to Immature Cataract (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRYAA	Crystallin Alpha A	Protein Coding	6.8	DISEASES inferred ¹⁴ ¹⁴
2	INTS9	Integrator Complex Subunit 9	Protein Coding	5.9	DISEASES inferred ¹⁴
3	CRYGS	Crystallin Gamma S	Protein Coding	4.88	DISEASES inferred ¹⁴
4	CRYBB2	Crystallin Beta B2	Protein Coding	4.46	DISEASES inferred ¹⁴
5	GTPBP1	GTP Binding Protein 1	Protein Coding	4.35	DISEASES inferred ¹⁴
6	CNBP	CCHC-Type Zinc Finger Nucleic Acid Binding Protein	Protein Coding	4.34	DISEASES inferred ¹⁴
7	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	4.34	DISEASES inferred ¹⁴
8	DMPK	DM1 Protein Kinase	Protein Coding	4.28	DISEASES inferred ¹⁴
9	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	4.25	DISEASES inferred ¹⁴
10	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	4.25	DISEASES inferred ¹⁴
11	CRYGB	Crystallin Gamma B	Protein Coding	4.22	DISEASES inferred ¹⁴

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Variations for Immature Cataract

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Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

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Pathways for Immature Cataract

Pathways related to Immature Cataract according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	O2/CO2 exchange in erythrocytes ⁶⁶ Show member pathways Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) ⁶⁶ Erythrocytes take up carbon dioxide and release oxygen ⁶⁶ Erythrocytes take up oxygen and release carbon dioxide ⁶⁶	10.18	HBA2 HBA1

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GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle lumen	GO:0071682	9.46	HBA2 HBA1
2	hemoglobin complex	GO:0005833	9.26	HBA2 HBA1
3	haptoglobin-hemoglobin complex	GO:0031838	8.92	HBA2 HBA1

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:0007601	9.76	CRYGS CRYGB CRYBB2 CRYAA
2	hydrogen peroxide catabolic process	GO:0042744	9.67	HBA2 HBA1
3	oxygen transport	GO:0015671	9.62	HBA2 HBA1
4	carbon dioxide transport	GO:0015670	9.56	HBA2 HBA1
5	nitric oxide transport	GO:0030185	9.26	HBA2 HBA1
6	lens development in camera-type eye	GO:0002088	9.23	CRYGS CRYGB CRYBB2 CRYAA

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxygen carrier activity	GO:0005344	9.56	HBA2 HBA1
2	organic acid binding	GO:0043177	9.46	HBA2 HBA1
3	haptoglobin binding	GO:0031720	9.26	HBA2 HBA1
4	structural constituent of eye lens	GO:0005212	9.23	CRYGS CRYGB CRYBB2 CRYAA

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Sources for Immature Cataract

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: IMM002 MIFTS: 28	Immature Cataract Categories: Eye diseases, Genetic diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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