Immature Cataract disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Immature Cataract

MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract ¹² ¹⁵ ⁷⁴

Incipient Senile Cataract ¹² ⁷⁴

Incipient Cataract ¹² ⁷⁴

Water Clefts ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of lens

Senile cataract

Senile incipient cataract

External Ids:

Disease Ontology ¹² DOID:10997

SNOMED-CT ⁶⁹ 52421005

ICD10 ³⁴ H25.0 H25.09

UMLS ⁷⁴ C0271163 C2939157 C2960113

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Summaries for Immature Cataract

MalaCards based summary : Immature Cataract, also known as incipient senile cataract, is related to phacolytic glaucoma and cataract. An important gene associated with Immature Cataract is MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3), and among its related pathways/superpathways are Malaria and African trypanosomiasis. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)

#	Related Disease	Score	Top Affiliating Genes
1	phacolytic glaucoma	11.1
2	cataract	10.3
3	alpha-thalassemia/mental retardation syndrome, chromosome 16-related	10.3	HBA1 HBA2
4	methemoglobinemia, beta-globin type	10.3	HBA1 HBA2
5	diabetes mellitus, insulin-dependent, 24	10.3	HBA1 HBA2
6	hydrops fetalis, nonimmune	10.3	HBA1 HBA2
7	hydrops fetalis	10.3	HBA1 HBA2
8	glutathione peroxidase deficiency	10.3	HBA1 HBA2
9	hypoglycemic coma	10.3	HBA1 HBA2
10	heinz body anemias	10.3	HBA1 HBA2
11	erythrocytosis, familial, 7	10.3	HBA1 HBA2
12	type 1 diabetes mellitus 7	10.3	HBA1 HBA2
13	type 1 diabetes mellitus 11	10.3	HBA1 HBA2
14	neurofibroma	10.2	NF1 NF2
15	neurofibromatosis, familial spinal	10.2	NF1 NF2
16	patterned macular dystrophy	10.2	ALLC MAPKAPK3
17	macular dystrophy, patterned, 3	10.2	ALLC MAPKAPK3
18	plexiform schwannoma	10.2	NF1 NF2
19	neurofibrosarcoma	10.2	NF1 NF2
20	plexiform neurofibroma	10.2	NF1 NF2
21	atypical neurofibroma	10.2	NF1 NF2
22	trigeminal nerve neoplasm	10.2	NF1 NF2
23	neurilemmoma	10.2	NF1 NF2
24	neurilemmoma of the fifth cranial nerve	10.2	NF1 NF2
25	amyloid tumor	10.2	NF1 NF2
26	alpha thalassemia-intellectual disability syndrome type 1	10.2	HBA1 HBA2
27	spinal meningioma	10.2	NF1 NF2
28	spinal canal and spinal cord meningioma	10.2	NF1 NF2
29	nephrogenic adenofibroma	10.2	HBA1 NF1
30	neurilemmomatosis	10.2	NF1 NF2
31	optic nerve neoplasm	10.1	NF1 NF2
32	acoustic neuroma	10.1	NF1 NF2
33	hemoglobin h disease	10.1	HBA1 HBA2
34	senile cataract	10.1
35	cellular schwannoma	10.1	NF1 NF2
36	hemoglobinopathy	10.1	HBA1 HBA2
37	neurofibromatosis, type ii	10.1	NF1 NF2
38	microcytic anemia	10.0	HBA1 HBA2
39	peripheral nervous system neoplasm	10.0	APP NF1 NF2
40	spinocerebellar ataxia 10	9.9	CCT3 CNBP
41	retinal vascular disease	9.9	HBA1 HBA2

Graphical network of the top 20 diseases related to Immature Cataract:

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Symptoms & Phenotypes for Immature Cataract

GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

²⁷ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.53	HBA1 HBA2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	9.53	HBA1 HBA2 NUCB1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.53	NUCB1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	9.53	NUCB1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	9.53	NUCB1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	9.53	HBA1 HBA2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.53	NUCB1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	9.53	NUCB1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-205	9.53	HBA1 HBA2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.53	NUCB1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-92	9.53	NUCB1
12	Increased cell migration	GR00055-A-3	9.13	MAPKAPK3 NF1 NF2

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Drugs & Therapeutics for Immature Cataract

Search Clinical Trials , NIH Clinical Center for Immature Cataract

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Genetic Tests for Immature Cataract

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Anatomical Context for Immature Cataract

MalaCards organs/tissues related to Immature Cataract:

⁴²

Eye

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Publications for Immature Cataract

Articles related to Immature Cataract:

#	Title	Authors	Year
1	Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). ( 27313415 )	Bhati H....Manjusha R.	2015
2	Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. ( 24303209 )	Oksuz H....TaA9kA+n I.	2013
3	Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? ( 21141000 )	Singh S.K....Surin L.	2009
4	Alterations in the Capsular Epithelium in Immature Cataract. ( 16693270 )	Clapp C.A.	1941
5	Preliminary Capsulotomy in the Operation for the Extraction of Immature Cataract. ( 16692312 )	Hansell H.F....Shannon C.E.	1914
6	The treatment of immature cataract. ( 16692145 )	Smith M.H.	1908
7	The Treatment of Immature Cataract. ( 29006593 )	Smith H.	1908
8	Extraction of lens in capsule as a method of procedure in cases of immature cataract. ( 16692079 )	Standish M.	1906
9	A Discussion on the Treatment of Immature Cataract. ( 20752810 )		1889

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Genes for Immature Cataract

Genes related to Immature Cataract (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MAPKAPK3	Mitogen-Activated Protein Kinase-Activated Protein Kinase 3	Protein Coding	16.34	DISEASES inferred ¹⁵
2	CNBP	CCHC-Type Zinc Finger Nucleic Acid Binding Protein	Protein Coding	14.98	DISEASES inferred ¹⁵
3	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	14.28	DISEASES inferred ¹⁵
4	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	14.28	DISEASES inferred ¹⁵
5	NF2	Neurofibromin 2	Protein Coding	14.24	DISEASES inferred ¹⁵
6	NF1	Neurofibromin 1	Protein Coding	13.6	DISEASES inferred ¹⁵
7	APP	Amyloid Beta Precursor Protein	Protein Coding	13.16	DISEASES inferred ¹⁵
8	VAT1	Vesicle Amine Transport 1	Protein Coding	6.67	DISEASES inferred ¹⁵
9	NUCB1	Nucleobindin 1	Protein Coding	6.44	DISEASES inferred ¹⁵
10	CCT3	Chaperonin Containing TCP1 Subunit 3	Protein Coding	5.4	DISEASES inferred ¹⁵
11	ALLC	Allantoicase	Protein Coding	5.17	DISEASES inferred ¹⁵

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Variations for Immature Cataract

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Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

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Pathways for Immature Cataract

Pathways related to Immature Cataract according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Malaria ³⁸	10.65	HBA1 HBA2
2	African trypanosomiasis ³⁸	10.19	HBA1 HBA2

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GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.97	APP CCT3 CNBP HBA1 HBA2 MAPKAPK3
2	extracellular exosome	GO:0070062	9.73	APP CCT3 HBA1 HBA2 NUCB1 VAT1
3	early endosome	GO:0005769	9.5	APP NF2 NUCB1
4	cytosolic small ribosomal subunit	GO:0022627	9.4	HBA1 HBA2
5	endocytic vesicle lumen	GO:0071682	9.16	HBA1 HBA2
6	hemoglobin complex	GO:0005833	8.96	HBA1 HBA2
7	haptoglobin-hemoglobin complex	GO:0031838	8.62	HBA1 HBA2

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to hydrogen peroxide	GO:0042542	9.48	HBA1 HBA2
2	positive regulation of cell death	GO:0010942	9.46	HBA1 HBA2
3	visual learning	GO:0008542	9.43	APP NF1
4	cognition	GO:0050890	9.4	APP NF1
5	bicarbonate transport	GO:0015701	9.37	HBA1 HBA2
6	hydrogen peroxide catabolic process	GO:0042744	9.32	HBA1 HBA2
7	negative regulation of MAPK cascade	GO:0043409	9.26	NF1 NF2
8	negative regulation of cell-matrix adhesion	GO:0001953	9.16	NF1 NF2
9	regulation of long-term neuronal synaptic plasticity	GO:0048169	8.96	APP NF1
10	oxygen transport	GO:0015671	8.62	HBA1 HBA2

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxygen binding	GO:0019825	9.32	HBA1 HBA2
2	peroxidase activity	GO:0004601	9.26	HBA1 HBA2
3	oxygen carrier activity	GO:0005344	9.16	HBA1 HBA2
4	organic acid binding	GO:0043177	8.96	HBA1 HBA2
5	haptoglobin binding	GO:0031720	8.62	HBA1 HBA2

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Sources for Immature Cataract

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia