MCID: IMM002
MIFTS: 28

Immature Cataract

Categories: Eye diseases, Genetic diseases, Neuronal diseases
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Aliases & Classifications for Immature Cataract

MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract 11 14 71
Incipient Senile Cataract 11 71
Incipient Cataract 11 71
Water Clefts 11

Classifications:



External Ids:

Disease Ontology 11 DOID:10997
SNOMED-CT 68 52421005
ICD10 31 H25.0
UMLS 71 C0271163 C2939157 C2960113

Summaries for Immature Cataract

Disease Ontology: 11 A senile cataract that is characterized by variable opacification of the lens of the eye with some clear lens fibers remaining.

MalaCards based summary: Immature Cataract, also known as incipient senile cataract, is related to presbyopia and senile cataract. An important gene associated with Immature Cataract is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways is O2/CO2 exchange in erythrocytes. Affiliated tissues include eye and endothelial, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 presbyopia 29.8 CRYGS CRYGB CRYBB2 CRYAA
2 senile cataract 29.7 CRYGS CRYGB CRYBB2 CRYAA
3 cataract 29.2 DMPK CRYGS CRYGB CRYBB2 CRYAA COL4A4
4 phacolytic glaucoma 11.1
5 morgagni cataract 10.2 CRYGS CRYAA
6 cataract microcornea syndrome 10.2 CRYBB2 CRYAA
7 retinal perforation 10.2 CRYGS CRYAA
8 early-onset sutural cataract 10.2 CRYGS CRYBB2
9 axenfeld-rieger syndrome, type 3 10.2 CRYGS CRYAA
10 early-onset nuclear cataract 10.2 CRYBB2 CRYAA
11 axenfeld-rieger syndrome 10.2 CRYGS CRYAA
12 galactosemia ii 10.2 CRYGS CRYAA
13 cataract 9, multiple types 10.2 CRYBB2 CRYAA
14 coloboma of optic nerve 10.2 CRYGS CRYAA
15 persistent hyperplastic primary vitreous 10.2 CRYGS CRYAA
16 brain small vessel disease 10.2 CRYAA COL4A4
17 cataract 24 10.1 CRYGB CRYAA
18 night blindness, congenital stationary, type 2a 10.1 CRYGB CRYAA
19 porencephaly 10.1 CRYAA COL4A4
20 cataract 48 10.1 CRYGB CRYAA
21 cataract 18 10.1 CRYGB CRYAA
22 abruzzo-erickson syndrome 10.1 CRYGB CRYAA
23 nuclear senile cataract 10.1 CRYGS CRYGB
24 papillorenal syndrome 10.1 CRYAA COL4A4
25 mature cataract 10.1 CRYGS CRYBB2 CRYAA
26 amblyopia 10.1 CRYGS CRYBB2 CRYAA
27 posterior polar cataract 10.1 CRYGS CRYBB2 CRYAA
28 nance-horan syndrome 10.1 CRYGS CRYBB2 CRYAA
29 aniridia 1 10.1 CRYGS CRYBB2 CRYAA
30 x-linked hereditary ataxia 10.0 DMPK CNBP
31 myotonia 10.0 DMPK CNBP
32 myotonic disease 10.0 DMPK CNBP
33 huntington disease-like 2 10.0 DMPK CNBP
34 early-onset lamellar cataract 10.0 CRYGS CRYGB CRYAA
35 deprivation amblyopia 10.0 CRYGS CRYGB CRYAA
36 eye accommodation disease 10.0 CRYGS CRYGB CRYAA
37 diabetic cataract 10.0 CRYGS CRYGB CRYAA
38 myotonic dystrophy 2 10.0 DMPK CNBP
39 myotonia congenita 10.0 DMPK CNBP
40 congenital aphakia 10.0 CRYGB CRYBB2 CRYAA
41 cataract 44 10.0 CRYGB CRYBB2 CRYAA
42 fragile x-associated tremor/ataxia syndrome 9.9 DMPK CNBP
43 spinal and bulbar muscular atrophy, x-linked 1 9.9 DMPK CRYAA CNBP
44 muscle tissue disease 9.9 DMPK CRYAA CNBP
45 muscular disease 9.9 DMPK CRYAA CNBP
46 autosomal dominant cerebellar ataxia 9.9 DMPK CRYAA CNBP
47 myopia 9.8
48 fuchs' endothelial dystrophy 9.8 DMPK COL4A4 CNBP
49 glutathione peroxidase deficiency 9.8 HBA2 HBA1
50 type 1 diabetes mellitus 24 9.8 HBA2 HBA1

Graphical network of the top 20 diseases related to Immature Cataract:



Diseases related to Immature Cataract

Symptoms & Phenotypes for Immature Cataract

GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

25 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.78 CRYBB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.78 GTPBP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.78 HBA1 HBA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.78 GTPBP1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.78 CRYBB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.78 HBA1 HBA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.78 GTPBP1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 GTPBP1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.78 HBA1 HBA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.78 CRYBB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 GTPBP1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.78 GTPBP1 HBA1 HBA2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.78 CRYBB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 GTPBP1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.78 CRYBB2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.78 CRYBB2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.78 CRYBB2

Drugs & Therapeutics for Immature Cataract

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Outcomes of Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Completed NCT02561104

Search NIH Clinical Center for Immature Cataract

Genetic Tests for Immature Cataract

Anatomical Context for Immature Cataract

Organs/tissues related to Immature Cataract:

MalaCards : Eye, Endothelial

Publications for Immature Cataract

Articles related to Immature Cataract:

(show top 50) (show all 109)
# Title Authors PMID Year
1
Ophthalmic Parameters and Ophthalmoscopy of Burrowing Owls (Athene cunicularia). 62
35972872 2022
2
Effect of oral antioxidants on the progression of canine senile cataracts: a retrospective study. 62
35466599 2022
3
Phacoemulsification and intraocular lens implantation in a Canada lynx with phacoclastic uveitis. 62
35237016 2022
4
[Evaluation of aqueous cytokine levels in eyes with Fuchs endothelial corneal dystrophy and bullous keratopathy]. 62
34156773 2021
5
A clinical study to assess feasibility, acceptance, and outcome of multifocal intraocular lens in patients with bilateral immature cataract at a tertiary eye care institute. 62
33120631 2020
6
Social impact indicators in patient diagnosed of senile cataract treated with phacoemulsification plus intraocular lens implantation. 62
32538985 2020
7
The protein-water nuclear Overhauser effect (NOE) as an indirect microscope for molecular surface mapping of interaction patterns. 62
31799520 2019
8
Ophthalmic examination findings and intraocular pressures in wild-caught African giant pouched rats (Cricetomys spp.). 62
29251400 2018
9
Volumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomography. 62
30338158 2018
10
Comparative Study of Extra Capsular Cataract Extraction (ECCE) and Small Incision Cataract Surgery (SICS): Experience on Cataract Surgery in a Tertiary Center of Army Hospital, Kathmandu. 62
31056560 2018
11
Rapid macular hole formation and closure in a vitrectomized eye following rhegmatogenous retinal detachment repair. 62
29563703 2018
12
Microsporidial infection masquerading as graft rejection post-Descemet's stripping automated endothelial keratoplasty. 62
28905834 2017
13
Intracameral mydriatics versus topical mydriatics in pupil dilation for phacoemulsification cataract surgery. 62
28917402 2017
14
Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients. 62
28666280 2017
15
Anterior lens epithelium in cataract patients with retinitis pigmentosa - scanning and transmission electron microscopy study. 62
27679403 2017
16
Modified penetrating keratoplasty with Acell® bioscaffold implant in seven horses with deep full-thickness corneal stromal abscess. 62
26840652 2017
17
[The concentration of cerebral natriuretic peptide in tear and blood serum.] 62
30856302 2017
18
Marathoning with myotonic dystrophy type 2 (proximal myotonic myopathy) and leukopenia. 62
28491317 2017
19
A case of keratitis associated with limbal relaxing incision. 62
28112139 2016
20
Phacoantigenic Reaction Masquerading as Postoperative Endophthalmitis in a Silicone Oil-filled Eye. 62
27994397 2016
21
Central corneal thickness changes in bevel-up versus bevel-down phacoemulsification cataract surgery: study protocol for a randomised, triple-blind, parallel group trial. 62
27687899 2016
22
[Intraocular pressure measurement inside the anterior chamber: a new technical solution and results]. 62
28121293 2016
23
Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). 62
27313415 2015
24
Manuel's asteroid disruption technique. 62
23571244 2015
25
Treatment of congenital aniridia associated with subluxated infantile cataract. 62
25568537 2014
26
Treatment of congenital aniridia associated with subluxated infantile cataract. 62
25195356 2014
27
Corneal edema after phacoemulsification surgery in patients with type II diabetes mellitus. 62
24172560 2013
28
Objective assessment of crystalline lens opacity level by measuring ocular light scattering with a double-pass system. 62
23317652 2013
29
Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. 62
24303209 2013
30
Cataract surgery after Descemet stripping endothelial keratoplasty. 62
23202404 2012
31
Tolerability and pharmacokinetics of intravitreal sirolimus. 62
22662868 2012
32
[Reduced glutathione level and GSH-dependent enzyme activities in corticonuclear blocks of lenses in patients with senile cataract]. 62
23289270 2012
33
Antioxidant capacity of lenses with age-related cataract. 62
22363833 2012
34
Septic lens implantation syndrome in a cat. 62
21923828 2011
35
Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f rat. 62
21147102 2011
36
[Biometry of anterior segment structures: comparative study]. 62
21394995 2010
37
[Treatment of fungal keratitis by penetrating keratoplasty]. 62
20684168 2010
38
Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? 62
21141000 2009
39
[Phacoemulsification in eyes with white cataracts: results and complications]. 62
18046274 2007
40
Pattern of eye diseases and visual impairment among students in southwestern Nigeria. 62
17585376 2007
41
Management of bilateral uveitis in a Toxoplasma gondii-seropositive cat with histopathologic evidence of fungal panuveitis. 62
17565553 2007
42
The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study. 62
16939459 2006
43
[Optic coherent tomography in patients with immature cataract and pseudophakia]. 62
16927778 2006
44
Biochemical researches in age related cataract. 62
16927758 2006
45
Prevalence and causes of blindness and visual impairment among school children in south-western Nigeria. 62
17200795 2005
46
[Multifocal phakic intraocular lens implant to correct presbyopia]. 62
15883490 2005
47
Surgical strategies in patients with cataract and glaucoma. 62
15650579 2005
48
Incidence of and risk factors for residual posterior capsule opacification after cataract surgery. 62
15519088 2004
49
Excessive maternal caffeine exposure during pregnancy is cataractogenic for neonatal crystalline lenses in rats: a biomicroscopic and histopathologic study. 62
15453852 2004
50
Lens morphometry determined by B-mode ultrasonography of the normal and cataractous canine lens. 62
14982588 2004

Variations for Immature Cataract

Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

Pathways for Immature Cataract

GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 9.46 HBA2 HBA1
2 hemoglobin complex GO:0005833 9.26 HBA2 HBA1
3 haptoglobin-hemoglobin complex GO:0031838 8.92 HBA2 HBA1

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.76 CRYGS CRYGB CRYBB2 CRYAA
2 hydrogen peroxide catabolic process GO:0042744 9.67 HBA2 HBA1
3 oxygen transport GO:0015671 9.62 HBA2 HBA1
4 carbon dioxide transport GO:0015670 9.56 HBA2 HBA1
5 nitric oxide transport GO:0030185 9.26 HBA2 HBA1
6 lens development in camera-type eye GO:0002088 9.23 CRYGS CRYGB CRYBB2 CRYAA

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen carrier activity GO:0005344 9.56 HBA2 HBA1
2 organic acid binding GO:0043177 9.46 HBA2 HBA1
3 haptoglobin binding GO:0031720 9.26 HBA2 HBA1
4 structural constituent of eye lens GO:0005212 9.23 CRYGS CRYGB CRYBB2 CRYAA

Sources for Immature Cataract

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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