MCID: IMM002
MIFTS: 29

Immature Cataract

Categories: Eye diseases

Aliases & Classifications for Immature Cataract

MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract 12 15 73
Incipient Senile Cataract 12 73
Incipient Cataract 12 73
Water Clefts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10997
ICD10 33 H25.09 H25.0
SNOMED-CT 68 193584004 52421005

Summaries for Immature Cataract

MalaCards based summary : Immature Cataract, also known as incipient senile cataract, is related to alpha-thalassemia/mental retardation syndrome, chromosome 16-related and methemoglobinemia, beta-globin type. An important gene associated with Immature Cataract is MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3), and among its related pathways/superpathways are Malaria and African trypanosomiasis. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.6 HBA1 HBA2
2 methemoglobinemia, beta-globin type 10.6 HBA1 HBA2
3 hydrops fetalis, nonimmune 10.6 HBA1 HBA2
4 diabetes mellitus, insulin-dependent, 24 10.6 HBA1 HBA2
5 glutathione peroxidase deficiency 10.5 HBA1 HBA2
6 neurofibromatosis, familial spinal 10.5 NF1 NF2
7 hypoglycemic coma 10.5 HBA1 HBA2
8 heinz body anemias 10.5 HBA1 HBA2
9 type 1 diabetes mellitus 7 10.5 HBA1 HBA2
10 type 1 diabetes mellitus 11 10.5 HBA1 HBA2
11 neurofibrosarcoma 10.5 NF1 NF2
12 plexiform schwannoma 10.5 NF1 NF2
13 patterned macular dystrophy 10.5 ALLC MAPKAPK3
14 plexiform neurofibroma 10.5 NF1 NF2
15 hydrops fetalis 10.5 HBA1 HBA2
16 atypical neurofibroma 10.5 NF1 NF2
17 rubeosis iridis 10.5 CRYAA HBA2
18 macular dystrophy, patterned, 3 10.5 ALLC MAPKAPK3
19 amyloid tumor 10.5 NF1 NF2
20 spinal meningioma 10.4 NF1 NF2
21 spinal canal and spinal cord meningioma 10.4 NF1 NF2
22 neurilemmomatosis 10.4 NF1 NF2
23 optic nerve neoplasm 10.4 NF1 NF2
24 acoustic neuroma 10.4 NF1 NF2
25 nephrogenic adenofibroma 10.3 HBA1 NF1
26 spinal cord ependymoma 10.3 NF1 NF2
27 cellular schwannoma 10.3 NF1 NF2
28 neurofibromatosis, type ii 10.2 NF1 NF2
29 hemoglobin h disease 10.2 HBA1 HBA2
30 cataract 10.2
31 neurilemmoma 10.2 NF1 NF2
32 neurofibroma 10.1 NF1 NF2
33 peripheral nervous system neoplasm 10.0 APP NF1 NF2
34 organ system benign neoplasm 10.0 NF1 NF2
35 spinocerebellar ataxia 10 9.9 CCT3 CNBP
36 hemoglobinopathy 9.7 HBA1 HBA2

Graphical network of the top 20 diseases related to Immature Cataract:



Diseases related to Immature Cataract

Symptoms & Phenotypes for Immature Cataract

GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 HBA1 HBA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 NUCB1 HBA1 HBA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.53 NUCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.53 NUCB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.53 NUCB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 HBA1 HBA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 NUCB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.53 NUCB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.53 HBA1 HBA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.53 NUCB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.53 NUCB1
12 Increased cell migration GR00055-A-3 9.13 MAPKAPK3 NF1 NF2

Drugs & Therapeutics for Immature Cataract

Search Clinical Trials , NIH Clinical Center for Immature Cataract

Genetic Tests for Immature Cataract

Anatomical Context for Immature Cataract

MalaCards organs/tissues related to Immature Cataract:

41
Eye

Publications for Immature Cataract

Articles related to Immature Cataract:

# Title Authors Year
1
Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). ( 27313415 )
2015
2
Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. ( 24303209 )
2013
3
Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? ( 21141000 )
2009
4
Alterations in the Capsular Epithelium in Immature Cataract. ( 16693270 )
1941
5
Preliminary Capsulotomy in the Operation for the Extraction of Immature Cataract. ( 16692312 )
1914
6
The treatment of immature cataract. ( 16692145 )
1908
7
The Treatment of Immature Cataract. ( 29006593 )
1908
8
Extraction of lens in capsule as a method of procedure in cases of immature cataract. ( 16692079 )
1906
9
A Discussion on the Treatment of Immature Cataract. ( 20752810 )
1889

Variations for Immature Cataract

Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

Pathways for Immature Cataract

Pathways related to Immature Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 HBA1 HBA2
2 10.5 HBA1 HBA2
3
Show member pathways
10.17 HBA1 HBA2

GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.91 APP CCT3 CNBP CRYAA HBA1 HBA2
2 extracellular exosome GO:0070062 9.87 APP CCT3 CRYAA HBA1 HBA2 NUCB1
3 cytosolic small ribosomal subunit GO:0022627 9.37 HBA1 HBA2
4 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
5 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
6 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 9.4 APP NF1
2 bicarbonate transport GO:0015701 9.37 HBA1 HBA2
3 negative regulation of MAPK cascade GO:0043409 9.32 NF1 NF2
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 APP NF1
5 negative regulation of cell-matrix adhesion GO:0001953 9.16 NF1 NF2
6 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
7 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.26 HBA1 HBA2
2 peroxidase activity GO:0004601 9.16 HBA1 HBA2
3 oxygen carrier activity GO:0005344 8.96 HBA1 HBA2
4 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Immature Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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