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MCID: IMM002
MIFTS: 30

Immature Cataract

Categories: Eye diseases, Genetic diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Immature Cataract

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MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract 12 15 74
Incipient Senile Cataract 12 74
Incipient Cataract 12 74
Water Clefts 12

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:10997
SNOMED-CT 69 52421005
ICD10 34 H25.0 H25.09
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Summaries for Immature Cataract

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MalaCards based summary : Immature Cataract, also known as incipient senile cataract, is related to phacolytic glaucoma and cataract. An important gene associated with Immature Cataract is CNBP (CCHC-Type Zinc Finger Nucleic Acid Binding Protein), and among its related pathways/superpathways are Neuroscience and Malaria. Affiliated tissues include eye and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Immature Cataract

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Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 phacolytic glaucoma 11.1
2 cataract 10.3
3 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.3 HBA1 HBA2
4 methemoglobinemia, beta-globin type 10.3 HBA1 HBA2
5 diabetes mellitus, insulin-dependent, 24 10.3 HBA1 HBA2
6 hydrops fetalis, nonimmune 10.3 HBA1 HBA2
7 hydrops fetalis 10.3 HBA1 HBA2
8 glutathione peroxidase deficiency 10.3 HBA1 HBA2
9 hypoglycemic coma 10.3 HBA1 HBA2
10 heinz body anemias 10.3 HBA1 HBA2
11 erythrocytosis, familial, 7 10.3 HBA1 HBA2
12 type 1 diabetes mellitus 7 10.3 HBA1 HBA2
13 type 1 diabetes mellitus 11 10.3 HBA1 HBA2
14 neurofibroma 10.2 NF1 NF2
15 neurofibromatosis, familial spinal 10.2 NF1 NF2
16 plexiform schwannoma 10.2 NF1 NF2
17 neurofibrosarcoma 10.2 NF1 NF2
18 alpha thalassemia-intellectual disability syndrome type 1 10.2 HBA1 HBA2
19 plexiform neurofibroma 10.2 NF1 NF2
20 atypical neurofibroma 10.2 NF1 NF2
21 trigeminal nerve neoplasm 10.2 NF1 NF2
22 neurilemmoma 10.2 NF1 NF2
23 neurilemmoma of the fifth cranial nerve 10.2 NF1 NF2
24 amyloid tumor 10.2 NF1 NF2
25 nephrogenic adenofibroma 10.2 HBA1 NF1
26 spinal meningioma 10.2 NF1 NF2
27 spinal canal and spinal cord meningioma 10.2 NF1 NF2
28 hemoglobin h disease 10.2 HBA1 HBA2
29 neurilemmomatosis 10.2 NF1 NF2
30 optic nerve neoplasm 10.2 NF1 NF2
31 hemoglobinopathy 10.2 HBA1 HBA2
32 acoustic neuroma 10.2 NF1 NF2
33 microcytic anemia 10.2 HBA1 HBA2
34 cellular schwannoma 10.1 NF1 NF2
35 retinal vascular disease 10.1 HBA1 HBA2
36 neurofibromatosis, type ii 10.1 NF1 NF2
37 senile cataract 10.1
38 central nervous system cancer 10.0 NF1 NF2
39 peripheral nervous system neoplasm 10.0 APP NF1 NF2
40 spinocerebellar ataxia 10 10.0 CCT3 CNBP
41 neurofibromatosis, type iv, of riccardi 9.9 NF1 NF2
42 sickle cell anemia 9.9 HBA1 HBA2
43 muscle tissue disease 9.8 CCT3 CNBP

Graphical network of the top 20 diseases related to Immature Cataract:



Diseases related to Immature Cataract
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Symptoms & Phenotypes for Immature Cataract

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GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 HBA1 HBA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 HBA1 HBA2 NUCB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.53 NUCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.53 NUCB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.53 NUCB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 HBA1 HBA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 NUCB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.53 NUCB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.53 HBA1 HBA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.53 NUCB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.53 NUCB1
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Drugs & Therapeutics for Immature Cataract

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Search Clinical Trials , NIH Clinical Center for Immature Cataract

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Genetic Tests for Immature Cataract

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Anatomical Context for Immature Cataract

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MalaCards organs/tissues related to Immature Cataract:

42
Eye, Spinal Cord
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Publications for Immature Cataract

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Articles related to Immature Cataract:

# Title Authors Year
1
Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). ( 27313415 )
2015
2
Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. ( 24303209 )
2013
3
Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? ( 21141000 )
2009
4
Use of 'Caracsol' (sodium-iodide in phospho-mono-calcic vehicle) in cases of incipient senile cataract. ( 6065036 )
1967
5
Alterations in the Capsular Epithelium in Immature Cataract. ( 16693270 )
1941
6
Preliminary Capsulotomy in the Operation for the Extraction of Immature Cataract. ( 16692312 )
1914
7
The treatment of immature cataract. ( 16692145 )
1908
8
The Treatment of Immature Cataract. ( 29006593 )
1908
9
Extraction of lens in capsule as a method of procedure in cases of immature cataract. ( 16692079 )
1906
10
A Discussion on the Treatment of Immature Cataract. ( 20752810 )
1889
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Variations for Immature Cataract

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Expression for Immature Cataract

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Search GEO for disease gene expression data for Immature Cataract.
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Pathways for Immature Cataract

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Pathways related to Immature Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.97 APP NF1 NF2
2
Malaria 38
10.85 HBA1 HBA2
3
African trypanosomiasis 38
10.52 HBA1 HBA2
4
Erythrocytes take up carbon dioxide and release oxygen 67
Show member pathways
 10.17 HBA1 HBA2
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GO Terms for Immature Cataract

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Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 APP CCT3 HBA1 HBA2 NUCB1 VAT1
2 early endosome GO:0005769 9.5 APP NF2 NUCB1
3 cytosolic small ribosomal subunit GO:0022627 9.37 HBA1 HBA2
4 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
5 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
6 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.48 HBA1 HBA2
2 positive regulation of cell death GO:0010942 9.46 HBA1 HBA2
3 visual learning GO:0008542 9.43 APP NF1
4 cognition GO:0050890 9.4 APP NF1
5 bicarbonate transport GO:0015701 9.37 HBA1 HBA2
6 hydrogen peroxide catabolic process GO:0042744 9.32 HBA1 HBA2
7 negative regulation of MAPK cascade GO:0043409 9.26 NF1 NF2
8 negative regulation of cell-matrix adhesion GO:0001953 9.16 NF1 NF2
9 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 APP NF1
10 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.32 HBA1 HBA2
2 peroxidase activity GO:0004601 9.26 HBA1 HBA2
3 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
4 organic acid binding GO:0043177 8.96 HBA1 HBA2
5 haptoglobin binding GO:0031720 8.62 HBA1 HBA2
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Sources for Immature Cataract

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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