Immature Cataract disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Immature Cataract

MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract ¹² ¹⁵ ⁷³

Incipient Senile Cataract ¹² ⁷³

Incipient Cataract ¹² ⁷³

Water Clefts ¹²

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the eye and adnexa

Disorders of lens

Senile cataract

Senile incipient cataract

External Ids:

Disease Ontology ¹² DOID:10997

ICD10 ³³ H25.09 H25.0

SNOMED-CT ⁶⁸ 193584004 52421005

UMLS ⁷³ C0271163 C2960113 C2939157

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Summaries for Immature Cataract

MalaCards based summary : Immature Cataract, also known as incipient senile cataract, is related to alpha-thalassemia/mental retardation syndrome, chromosome 16-related and methemoglobinemia, beta-globin type. An important gene associated with Immature Cataract is MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3), and among its related pathways/superpathways are Malaria and African trypanosomiasis. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)

#	Related Disease	Score	Top Affiliating Genes
1	alpha-thalassemia/mental retardation syndrome, chromosome 16-related	10.6	HBA1 HBA2
2	methemoglobinemia, beta-globin type	10.6	HBA1 HBA2
3	hydrops fetalis, nonimmune	10.6	HBA1 HBA2
4	diabetes mellitus, insulin-dependent, 24	10.6	HBA1 HBA2
5	glutathione peroxidase deficiency	10.5	HBA1 HBA2
6	neurofibromatosis, familial spinal	10.5	NF1 NF2
7	hypoglycemic coma	10.5	HBA1 HBA2
8	heinz body anemias	10.5	HBA1 HBA2
9	type 1 diabetes mellitus 7	10.5	HBA1 HBA2
10	type 1 diabetes mellitus 11	10.5	HBA1 HBA2
11	neurofibrosarcoma	10.5	NF1 NF2
12	plexiform schwannoma	10.5	NF1 NF2
13	patterned macular dystrophy	10.5	ALLC MAPKAPK3
14	plexiform neurofibroma	10.5	NF1 NF2
15	hydrops fetalis	10.5	HBA1 HBA2
16	atypical neurofibroma	10.5	NF1 NF2
17	rubeosis iridis	10.5	CRYAA HBA2
18	macular dystrophy, patterned, 3	10.5	ALLC MAPKAPK3
19	amyloid tumor	10.5	NF1 NF2
20	spinal meningioma	10.4	NF1 NF2
21	spinal canal and spinal cord meningioma	10.4	NF1 NF2
22	neurilemmomatosis	10.4	NF1 NF2
23	optic nerve neoplasm	10.4	NF1 NF2
24	acoustic neuroma	10.4	NF1 NF2
25	nephrogenic adenofibroma	10.3	HBA1 NF1
26	spinal cord ependymoma	10.3	NF1 NF2
27	cellular schwannoma	10.3	NF1 NF2
28	neurofibromatosis, type ii	10.2	NF1 NF2
29	hemoglobin h disease	10.2	HBA1 HBA2
30	cataract	10.2
31	neurilemmoma	10.2	NF1 NF2
32	neurofibroma	10.1	NF1 NF2
33	peripheral nervous system neoplasm	10.0	APP NF1 NF2
34	organ system benign neoplasm	10.0	NF1 NF2
35	spinocerebellar ataxia 10	9.9	CCT3 CNBP
36	hemoglobinopathy	9.7	HBA1 HBA2

Graphical network of the top 20 diseases related to Immature Cataract:

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Symptoms & Phenotypes for Immature Cataract

GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.53	HBA1 HBA2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	9.53	NUCB1 HBA1 HBA2
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.53	NUCB1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	9.53	NUCB1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	9.53	NUCB1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	9.53	HBA1 HBA2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.53	NUCB1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	9.53	NUCB1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-205	9.53	HBA1 HBA2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.53	NUCB1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-92	9.53	NUCB1
12	Increased cell migration	GR00055-A-3	9.13	MAPKAPK3 NF1 NF2

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Drugs & Therapeutics for Immature Cataract

Search Clinical Trials , NIH Clinical Center for Immature Cataract

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Genetic Tests for Immature Cataract

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Anatomical Context for Immature Cataract

MalaCards organs/tissues related to Immature Cataract:

⁴¹

Eye

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Publications for Immature Cataract

Articles related to Immature Cataract:

#	Title	Authors	Year
1	Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). ( 27313415 )	Bhati H....Manjusha R.	2015
2	Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. ( 24303209 )	Oksuz H....TaA9kA+n I.	2013
3	Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? ( 21141000 )	Singh S.K....Surin L.	2009
4	Alterations in the Capsular Epithelium in Immature Cataract. ( 16693270 )	Clapp C.A.	1941
5	Preliminary Capsulotomy in the Operation for the Extraction of Immature Cataract. ( 16692312 )	Hansell H.F....Shannon C.E.	1914
6	The treatment of immature cataract. ( 16692145 )	Smith M.H.	1908
7	The Treatment of Immature Cataract. ( 29006593 )	Smith H.	1908
8	Extraction of lens in capsule as a method of procedure in cases of immature cataract. ( 16692079 )	Standish M.	1906
9	A Discussion on the Treatment of Immature Cataract. ( 20752810 )		1889

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Genes for Immature Cataract

Genes related to Immature Cataract (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MAPKAPK3	Mitogen-Activated Protein Kinase-Activated Protein Kinase 3	Protein Coding	16.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CRYAA	Crystallin Alpha A	Protein Coding	15.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	CNBP	CCHC-Type Zinc Finger Nucleic Acid Binding Protein	Protein Coding	14.9	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	NF2	Neurofibromin 2	Protein Coding	14.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	14.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	NF1	Neurofibromin 1	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	APP	Amyloid Beta Precursor Protein	Protein Coding	13.12	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	VAT1	Vesicle Amine Transport 1	Protein Coding	6.61	DISEASES inferred ¹⁵
10	NUCB1	Nucleobindin 1	Protein Coding	6.48	DISEASES inferred ¹⁵
11	CCT3	Chaperonin Containing TCP1 Subunit 3	Protein Coding	5.38	DISEASES inferred ¹⁵
12	ALLC	Allantoicase	Protein Coding	5.07	DISEASES inferred ¹⁵

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Variations for Immature Cataract

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Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

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Pathways for Immature Cataract

Pathways related to Immature Cataract according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Malaria ³⁷	10.85	HBA1 HBA2
2	African trypanosomiasis ³⁷	10.5	HBA1 HBA2
3	O2/CO2 exchange in erythrocytes ⁶⁶ Show member pathways Erythrocytes take up carbon dioxide and release oxygen ⁶⁶ Erythrocytes take up oxygen and release carbon dioxide ⁶⁶	10.17	HBA1 HBA2

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GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.91	APP CCT3 CNBP CRYAA HBA1 HBA2
2	extracellular exosome	GO:0070062	9.87	APP CCT3 CRYAA HBA1 HBA2 NUCB1
3	cytosolic small ribosomal subunit	GO:0022627	9.37	HBA1 HBA2
4	endocytic vesicle lumen	GO:0071682	9.16	HBA1 HBA2
5	hemoglobin complex	GO:0005833	8.96	HBA1 HBA2
6	haptoglobin-hemoglobin complex	GO:0031838	8.62	HBA1 HBA2

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual learning	GO:0008542	9.4	APP NF1
2	bicarbonate transport	GO:0015701	9.37	HBA1 HBA2
3	negative regulation of MAPK cascade	GO:0043409	9.32	NF1 NF2
4	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.26	APP NF1
5	negative regulation of cell-matrix adhesion	GO:0001953	9.16	NF1 NF2
6	hydrogen peroxide catabolic process	GO:0042744	8.96	HBA1 HBA2
7	oxygen transport	GO:0015671	8.62	HBA1 HBA2

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxygen binding	GO:0019825	9.26	HBA1 HBA2
2	peroxidase activity	GO:0004601	9.16	HBA1 HBA2
3	oxygen carrier activity	GO:0005344	8.96	HBA1 HBA2
4	haptoglobin binding	GO:0031720	8.62	HBA1 HBA2

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Sources for Immature Cataract

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia