MCID: IMM002
MIFTS: 30

Immature Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Immature Cataract

MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract 12 15 74
Incipient Senile Cataract 12 74
Incipient Cataract 12 74
Water Clefts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10997
SNOMED-CT 69 52421005
ICD10 34 H25.0 H25.09

Summaries for Immature Cataract

MalaCards based summary : Immature Cataract, also known as incipient senile cataract, is related to phacolytic glaucoma and cataract. An important gene associated with Immature Cataract is MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3), and among its related pathways/superpathways are Malaria and African trypanosomiasis. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 phacolytic glaucoma 11.1
2 cataract 10.3
3 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.3 HBA1 HBA2
4 methemoglobinemia, beta-globin type 10.3 HBA1 HBA2
5 diabetes mellitus, insulin-dependent, 24 10.3 HBA1 HBA2
6 hydrops fetalis, nonimmune 10.3 HBA1 HBA2
7 hydrops fetalis 10.3 HBA1 HBA2
8 glutathione peroxidase deficiency 10.3 HBA1 HBA2
9 hypoglycemic coma 10.3 HBA1 HBA2
10 heinz body anemias 10.3 HBA1 HBA2
11 erythrocytosis, familial, 7 10.3 HBA1 HBA2
12 type 1 diabetes mellitus 7 10.3 HBA1 HBA2
13 type 1 diabetes mellitus 11 10.3 HBA1 HBA2
14 neurofibroma 10.2 NF1 NF2
15 neurofibromatosis, familial spinal 10.2 NF1 NF2
16 patterned macular dystrophy 10.2 ALLC MAPKAPK3
17 macular dystrophy, patterned, 3 10.2 ALLC MAPKAPK3
18 plexiform schwannoma 10.2 NF1 NF2
19 neurofibrosarcoma 10.2 NF1 NF2
20 plexiform neurofibroma 10.2 NF1 NF2
21 atypical neurofibroma 10.2 NF1 NF2
22 trigeminal nerve neoplasm 10.2 NF1 NF2
23 neurilemmoma 10.2 NF1 NF2
24 neurilemmoma of the fifth cranial nerve 10.2 NF1 NF2
25 amyloid tumor 10.2 NF1 NF2
26 alpha thalassemia-intellectual disability syndrome type 1 10.2 HBA1 HBA2
27 spinal meningioma 10.2 NF1 NF2
28 spinal canal and spinal cord meningioma 10.2 NF1 NF2
29 nephrogenic adenofibroma 10.2 HBA1 NF1
30 neurilemmomatosis 10.2 NF1 NF2
31 optic nerve neoplasm 10.1 NF1 NF2
32 acoustic neuroma 10.1 NF1 NF2
33 hemoglobin h disease 10.1 HBA1 HBA2
34 senile cataract 10.1
35 cellular schwannoma 10.1 NF1 NF2
36 hemoglobinopathy 10.1 HBA1 HBA2
37 neurofibromatosis, type ii 10.1 NF1 NF2
38 microcytic anemia 10.0 HBA1 HBA2
39 peripheral nervous system neoplasm 10.0 APP NF1 NF2
40 spinocerebellar ataxia 10 9.9 CCT3 CNBP
41 retinal vascular disease 9.9 HBA1 HBA2

Graphical network of the top 20 diseases related to Immature Cataract:



Diseases related to Immature Cataract

Symptoms & Phenotypes for Immature Cataract

GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 HBA1 HBA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 HBA1 HBA2 NUCB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.53 NUCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.53 NUCB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.53 NUCB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 HBA1 HBA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 NUCB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.53 NUCB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.53 HBA1 HBA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.53 NUCB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.53 NUCB1
12 Increased cell migration GR00055-A-3 9.13 MAPKAPK3 NF1 NF2

Drugs & Therapeutics for Immature Cataract

Search Clinical Trials , NIH Clinical Center for Immature Cataract

Genetic Tests for Immature Cataract

Anatomical Context for Immature Cataract

MalaCards organs/tissues related to Immature Cataract:

42
Eye

Publications for Immature Cataract

Articles related to Immature Cataract:

# Title Authors Year
1
Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). ( 27313415 )
2015
2
Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. ( 24303209 )
2013
3
Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? ( 21141000 )
2009
4
Alterations in the Capsular Epithelium in Immature Cataract. ( 16693270 )
1941
5
Preliminary Capsulotomy in the Operation for the Extraction of Immature Cataract. ( 16692312 )
1914
6
The treatment of immature cataract. ( 16692145 )
1908
7
The Treatment of Immature Cataract. ( 29006593 )
1908
8
Extraction of lens in capsule as a method of procedure in cases of immature cataract. ( 16692079 )
1906
9
A Discussion on the Treatment of Immature Cataract. ( 20752810 )
1889

Variations for Immature Cataract

Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

Pathways for Immature Cataract

Pathways related to Immature Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.65 HBA1 HBA2
2 10.19 HBA1 HBA2

GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.97 APP CCT3 CNBP HBA1 HBA2 MAPKAPK3
2 extracellular exosome GO:0070062 9.73 APP CCT3 HBA1 HBA2 NUCB1 VAT1
3 early endosome GO:0005769 9.5 APP NF2 NUCB1
4 cytosolic small ribosomal subunit GO:0022627 9.4 HBA1 HBA2
5 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
6 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
7 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.48 HBA1 HBA2
2 positive regulation of cell death GO:0010942 9.46 HBA1 HBA2
3 visual learning GO:0008542 9.43 APP NF1
4 cognition GO:0050890 9.4 APP NF1
5 bicarbonate transport GO:0015701 9.37 HBA1 HBA2
6 hydrogen peroxide catabolic process GO:0042744 9.32 HBA1 HBA2
7 negative regulation of MAPK cascade GO:0043409 9.26 NF1 NF2
8 negative regulation of cell-matrix adhesion GO:0001953 9.16 NF1 NF2
9 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 APP NF1
10 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.32 HBA1 HBA2
2 peroxidase activity GO:0004601 9.26 HBA1 HBA2
3 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
4 organic acid binding GO:0043177 8.96 HBA1 HBA2
5 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Immature Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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