MCID: IMM002
MIFTS: 28

Immature Cataract

Categories: Eye diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Immature Cataract

MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract 12 15 71
Incipient Senile Cataract 12 71
Incipient Cataract 12 71
Water Clefts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10997
SNOMED-CT 67 52421005
ICD10 32 H25.0 H25.09
UMLS 71 C0271163 C2939157 C2960113

Summaries for Immature Cataract

Disease Ontology : 12 A senile cataract that is characterized by variable opacification of the lens of the eye with some clear lens fibers remaining.

MalaCards based summary : Immature Cataract, also known as incipient senile cataract, is related to presbyopia and cataract. An important gene associated with Immature Cataract is CRYAA (Crystallin Alpha A). The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotype is vision/eye.

Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 presbyopia 30.0 MIP CRYGB CRYAA
2 cataract 29.1 MIP GJA8 GJA3 DMPK CRYGB CRYAA
3 phacolytic glaucoma 11.0
4 posterior polar cataract 10.2 GJA3 CRYAA
5 early-onset posterior polar cataract 10.2 MIP GJA3
6 cataract 9, multiple types 10.2 GJA8 CRYAA
7 early-onset sutural cataract 10.2 MIP GJA8
8 sclerocornea 10.1 GJA8 CRYAA
9 cataract 30, multiple types 10.1 GJA8 GJA3
10 cataract 14, multiple types 10.1 GJA8 GJA3
11 cataract microcornea syndrome 10.1 GJA8 CRYAA
12 morgagni cataract 10.1 CRYGB CRYAA
13 cataract 24 10.1 CRYGB CRYAA
14 congenital aphakia 10.1 CRYGB CRYAA
15 congenital nystagmus 10.1 GJA8 CRYAA
16 oculodentodigital dysplasia 10.1 GJA8 GJA3
17 cataract 48 10.1 CRYGB CRYAA
18 nance-horan syndrome 10.1 GJA8 CRYAA
19 night blindness, congenital stationary, type 2a 10.1 CRYGB CRYAA
20 myotonia 10.0 DMPK CNBP
21 mature cataract 10.0 MIP GJA8 CRYAA
22 x-linked hereditary ataxia 10.0 DMPK CNBP
23 cataract 1, multiple types 10.0 GJA8 GJA3 CRYAA
24 senile cataract 10.0
25 amblyopia 10.0 GJA8 GJA3 CRYAA
26 erythrokeratodermia variabilis et progressiva 1 10.0 GJA8 GJA3 CRYAA
27 myotonic dystrophy 2 10.0 DMPK CNBP
28 myotonic dystrophy 10.0 DMPK CNBP
29 myotonic disease 10.0 DMPK CNBP
30 early-onset lamellar cataract 9.9 MIP CRYGB CRYAA
31 eye accommodation disease 9.9 MIP CRYGB CRYAA
32 porencephaly 9.9 CRYGB CRYAA
33 huntington disease-like 2 9.9 DMPK CNBP
34 abruzzo-erickson syndrome 9.9 GJA3 CRYGB CRYAA
35 axenfeld-rieger syndrome, type 3 9.9 GJA8 CRYAA
36 spinocerebellar ataxia 8 9.9 DMPK CNBP
37 early-onset non-syndromic cataract 9.9 MIP GJA3 CRYGB
38 muscle tissue disease 9.9 DMPK CRYAA CNBP
39 muscular disease 9.9 DMPK CRYAA CNBP
40 yemenite deaf-blind hypopigmentation syndrome 9.8
41 oculopharyngeal muscular dystrophy 9.8 DMPK CNBP
42 autosomal dominant cerebellar ataxia 9.8 DMPK CRYAA CNBP
43 early-onset nuclear cataract 9.8 MIP GJA8 GJA3 CRYAA
44 neuromuscular disease 9.8 DMPK CRYAA CNBP
45 spinal and bulbar muscular atrophy, x-linked 1 9.7 DMPK CRYAA
46 cataract 44 9.7 MIP GJA8 CRYGB CRYAA
47 frontotemporal dementia 9.6 REST DMPK CNBP
48 lens disease 9.0 MIP GJA8 GJA3 DMPK CRYGB CRYAA

Graphical network of the top 20 diseases related to Immature Cataract:



Diseases related to Immature Cataract

Symptoms & Phenotypes for Immature Cataract

MGI Mouse Phenotypes related to Immature Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.1 CNBP CRYGB GJA3 GJA8 MIP REST

Drugs & Therapeutics for Immature Cataract

Drugs for Immature Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved 1401-55-4
2
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
3
Dipivefrin Approved 52365-63-6 3105

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Outcomes of Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Completed NCT02561104
2 Asymmetric Elongation of Foveal Tissue After Macular Hole Surgery and Its Impact on Metamorphopsia Completed NCT01471912

Search NIH Clinical Center for Immature Cataract

Genetic Tests for Immature Cataract

Anatomical Context for Immature Cataract

MalaCards organs/tissues related to Immature Cataract:

40
Eye, Endothelial

Publications for Immature Cataract

Articles related to Immature Cataract:

(show top 50) (show all 51)
# Title Authors PMID Year
1
A clinical study to assess feasibility, acceptance, and outcome of multifocal intraocular lens in patients with bilateral immature cataract at a tertiary eye care institute. 61
33120631 2020
2
Social impact indicators in patient diagnosed of senile cataract treated with phacoemulsification plus intraocular lens implantation. 61
32538985 2020
3
Ophthalmic examination findings and intraocular pressures in wild-caught African giant pouched rats (Cricetomys spp.). 61
29251400 2018
4
Comparative Study of Extra Capsular Cataract Extraction (ECCE) and Small Incision Cataract Surgery (SICS): Experience on Cataract Surgery in a Tertiary Center of Army Hospital, Kathmandu. 61
31056560 2018
5
Rapid macular hole formation and closure in a vitrectomized eye following rhegmatogenous retinal detachment repair. 61
29563703 2018
6
Microsporidial infection masquerading as graft rejection post-Descemet's stripping automated endothelial keratoplasty. 61
28905834 2017
7
Intracameral mydriatics versus topical mydriatics in pupil dilation for phacoemulsification cataract surgery. 61
28917402 2017
8
[The concentration of cerebral natriuretic peptide in tear and blood serum.] 61
30856302 2017
9
A case of keratitis associated with limbal relaxing incision. 61
28112139 2016
10
Phacoantigenic Reaction Masquerading as Postoperative Endophthalmitis in a Silicone Oil-filled Eye. 61
27994397 2016
11
Central corneal thickness changes in bevel-up versus bevel-down phacoemulsification cataract surgery: study protocol for a randomised, triple-blind, parallel group trial. 61
27687899 2016
12
[Intraocular pressure measurement inside the anterior chamber: a new technical solution and results]. 61
28121293 2016
13
Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). 61
27313415 2015
14
Manuel's asteroid disruption technique. 61
23571244 2015
15
Corneal edema after phacoemulsification surgery in patients with type II diabetes mellitus. 61
24172560 2013
16
Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. 61
24303209 2013
17
[Biometry of anterior segment structures: comparative study]. 61
21394995 2010
18
Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? 61
21141000 2009
19
[Phacoemulsification in eyes with white cataracts: results and complications]. 61
18046274 2007
20
Pattern of eye diseases and visual impairment among students in southwestern Nigeria. 61
17585376 2007
21
Management of bilateral uveitis in a Toxoplasma gondii-seropositive cat with histopathologic evidence of fungal panuveitis. 61
17565553 2007
22
The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study. 61
16939459 2006
23
[Optic coherent tomography in patients with immature cataract and pseudophakia]. 61
16927778 2006
24
Prevalence and causes of blindness and visual impairment among school children in south-western Nigeria. 61
17200795 2005
25
Incidence of and risk factors for residual posterior capsule opacification after cataract surgery. 61
15519088 2004
26
Excessive maternal caffeine exposure during pregnancy is cataractogenic for neonatal crystalline lenses in rats: a biomicroscopic and histopathologic study. 61
15453852 2004
27
Lens morphometry determined by B-mode ultrasonography of the normal and cataractous canine lens. 61
14982588 2004
28
Effect of nicotine exposure during gestation on neonatal rat crystalline lenses. 61
14707970 2004
29
Long-term management of a glaucomatous eye in a dog treated with medical therapy alone. 61
11789611 2001
30
Posterior lenticonus with congenital cataract in a Shih Tzu dog. 61
11129866 2000
31
Myopia among the Inuit population of East Greenland. Longitudinal Study 1950-1994. 61
9527340 1997
32
[Biochemical aspects in the pathogenesis of senile cataract]. 61
9409962 1997
33
Ultrasonographic abnormalities in the eyes of dogs with cataracts: 147 cases (1986-1992). 61
8226239 1993
34
Advanced versus immature cataracts--a preliminary report. 61
2764436 1989
35
New quantitative method to determine protein concentration and cell number in aqueous in vivo. 61
3054216 1988
36
Changes in the distribution of lens calcium during development of x-ray cataract. 61
6224754 1983
37
Ophthalmic technology for the clinician: direct ophthalmoscopy revisited. 61
7165227 1982
38
The Verhoeff capsule forceps: clinical and experimental results. 61
7247198 1981
39
Immune complexes in the aqueous humor and serum. 61
900214 1977
40
[Slit lamp studies on incipient senile cataract. II]. 61
5102428 1971
41
[Slit lamp studies on incipient senile cataract. I]. 61
5099710 1971
42
Use of 'Caracsol' (sodium-iodide in phospho-mono-calcic vehicle) in cases of incipient senile cataract. 61
6065036 1967
43
[Incipient senile cataract and presbyopia]. 61
5873273 1965
44
[Histopathological observations of human immature cataract]. 61
5894440 1965
45
[Remote results of the treatment of incipient senile cataract by instillation of drops containing cysteine]. 61
5887603 1965
46
Alterations in the Capsular Epithelium in Immature Cataract. 61
16693270 1941
47
Preliminary Capsulotomy in the Operation for the Extraction of Immature Cataract. 61
16692312 1914
48
The Treatment of Immature Cataract. 61
29006593 1908
49
The treatment of immature cataract. 61
16692145 1908
50
Extraction of lens in capsule as a method of procedure in cases of immature cataract. 61
16692079 1906

Variations for Immature Cataract

Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

Pathways for Immature Cataract

GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 connexin complex GO:0005922 8.96 GJA8 GJA3
2 gap junction GO:0005921 8.8 MIP GJA8 GJA3

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.46 MIP GJA3 CRYGB CRYAA
2 cell communication GO:0007154 9.26 GJA8 GJA3
3 lens development in camera-type eye GO:0002088 9.13 MIP GJA8 CRYGB
4 gap junction-mediated intercellular transport GO:1990349 8.8 MIP GJA8 GJA3

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.96 GJA8 GJA3
2 structural constituent of eye lens GO:0005212 8.8 MIP CRYGB CRYAA

Sources for Immature Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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