MCID: IMM002
MIFTS: 34

Immature Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Immature Cataract

MalaCards integrated aliases for Immature Cataract:

Name: Immature Cataract 12 15 73
Incipient Senile Cataract 12 73
Incipient Cataract 12 73
Water Clefts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10997
ICD10 33 H25.09 H25.0
SNOMED-CT 68 52421005

Summaries for Immature Cataract

MalaCards based summary : Immature Cataract, also known as incipient senile cataract, is related to phacolytic glaucoma and cataract. An important gene associated with Immature Cataract is MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3), and among its related pathways/superpathways are Malaria and African trypanosomiasis. Affiliated tissues include eye and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Immature Cataract

Diseases related to Immature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 phacolytic glaucoma 11.1
2 cataract 10.3
3 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.2 HBA2 HBA1
4 methemoglobinemia, beta-globin type 10.2 HBA2 HBA1
5 neurofibroma 10.2 NF2 NF1
6 diabetes mellitus, insulin-dependent, 24 10.2 HBA2 HBA1
7 neurofibromatosis, familial spinal 10.2 NF2 NF1
8 hydrops fetalis, nonimmune 10.2 HBA2 HBA1
9 hydrops fetalis 10.2 HBA2 HBA1
10 glutathione peroxidase deficiency 10.2 HBA2 HBA1
11 immune hydrops fetalis 10.2 HBA2 HBA1
12 hypoglycemic coma 10.2 HBA2 HBA1
13 plexiform schwannoma 10.2 NF2 NF1
14 erythrocytosis, familial, 7 10.2 HBA2 HBA1
15 heinz body anemias 10.2 HBA2 HBA1
16 patterned macular dystrophy 10.2 MAPKAPK3 ALLC
17 type 1 diabetes mellitus 7 10.2 HBA2 HBA1
18 atypical neurofibroma 10.2 NF2 NF1
19 type 1 diabetes mellitus 11 10.1 HBA2 HBA1
20 plexiform neurofibroma 10.1 NF2 NF1
21 neurofibrosarcoma 10.1 NF2 NF1
22 amyloid tumor 10.1 NF2 NF1
23 neurilemmoma 10.1 NF2 NF1
24 macular dystrophy, patterned, 3 10.1 MAPKAPK3 ALLC
25 neurilemmoma of the fifth cranial nerve 10.1 NF2 NF1
26 trigeminal nerve neoplasm 10.1 NF2 NF1
27 rubeosis iridis 10.1 HBA2 CRYAA
28 spinal canal and spinal cord meningioma 10.1 NF2 NF1
29 spinal meningioma 10.1 NF2 NF1
30 neurilemmomatosis 10.1 NF2 NF1
31 optic nerve neoplasm 10.1 NF2 NF1
32 senile cataract 10.1
33 acoustic neuroma 10.1 NF2 NF1
34 nephrogenic adenofibroma 10.1 NF1 HBA1
35 nervous system benign neoplasm 10.1 NF2 NF1
36 cellular schwannoma 10.0 NF2 NF1
37 alpha thalassemia-intellectual disability syndrome type 1 10.0 HBA2 HBA1
38 peripheral nervous system neoplasm 10.0 NF2 NF1 APP
39 neurofibromatosis, type ii 10.0 NF2 NF1
40 spinocerebellar ataxia 10 9.9 CNBP CCT3
41 hemoglobin h disease 9.9 HBA2 HBA1

Graphical network of the top 20 diseases related to Immature Cataract:



Diseases related to Immature Cataract

Symptoms & Phenotypes for Immature Cataract

GenomeRNAi Phenotypes related to Immature Cataract according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 HBA1 HBA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 HBA1 HBA2 NUCB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.53 NUCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.53 NUCB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.53 NUCB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 HBA1 HBA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 NUCB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.53 NUCB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.53 HBA1 HBA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.53 NUCB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.53 NUCB1
12 Increased cell migration GR00055-A-3 9.13 MAPKAPK3 NF1 NF2

Drugs & Therapeutics for Immature Cataract

Search Clinical Trials , NIH Clinical Center for Immature Cataract

Genetic Tests for Immature Cataract

Anatomical Context for Immature Cataract

MalaCards organs/tissues related to Immature Cataract:

41
Eye, Spinal Cord

Publications for Immature Cataract

Articles related to Immature Cataract:

# Title Authors Year
1
Clinical study on evaluation of anti-cataract effect of Triphaladi Ghana Vati and Elaneer Kuzhambu Anjana in Timira (immature cataract). ( 27313415 )
2015
2
Vacuum-assisted continuous circular capsulorhexis using bimanual irrigation and aspiration system of phaco machine in immature cataract. ( 24303209 )
2013
3
Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? ( 21141000 )
2009
4
Alterations in the Capsular Epithelium in Immature Cataract. ( 16693270 )
1941
5
Preliminary Capsulotomy in the Operation for the Extraction of Immature Cataract. ( 16692312 )
1914
6
The treatment of immature cataract. ( 16692145 )
1908
7
The Treatment of Immature Cataract. ( 29006593 )
1908
8
Extraction of lens in capsule as a method of procedure in cases of immature cataract. ( 16692079 )
1906
9
A Discussion on the Treatment of Immature Cataract. ( 20752810 )
1889

Variations for Immature Cataract

Expression for Immature Cataract

Search GEO for disease gene expression data for Immature Cataract.

Pathways for Immature Cataract

Pathways related to Immature Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 HBA1 HBA2
2 10.5 HBA1 HBA2
3
Show member pathways
10.17 HBA1 HBA2

GO Terms for Immature Cataract

Cellular components related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.91 APP CCT3 CNBP CRYAA HBA1 HBA2
2 extracellular exosome GO:0070062 9.8 APP CCT3 HBA1 HBA2 NUCB1 VAT1
3 early endosome GO:0005769 9.54 APP NF2 NUCB1
4 cytosolic small ribosomal subunit GO:0022627 9.4 HBA1 HBA2
5 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
6 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
7 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell death GO:0010942 9.46 HBA1 HBA2
2 visual learning GO:0008542 9.43 APP NF1
3 cognition GO:0050890 9.4 APP NF1
4 bicarbonate transport GO:0015701 9.37 HBA1 HBA2
5 hydrogen peroxide catabolic process GO:0042744 9.32 HBA1 HBA2
6 negative regulation of MAPK cascade GO:0043409 9.26 NF1 NF2
7 negative regulation of cell-matrix adhesion GO:0001953 9.16 NF1 NF2
8 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 APP NF1
9 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Immature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.32 HBA1 HBA2
2 peroxidase activity GO:0004601 9.26 HBA1 HBA2
3 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
4 organic acid binding GO:0043177 8.96 HBA1 HBA2
5 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Immature Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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