MCID: IMM005
MIFTS: 31

Immature Teratoma of Ovary

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Immature Teratoma of Ovary

MalaCards integrated aliases for Immature Teratoma of Ovary:

Name: Immature Teratoma of Ovary 12 58 15 71
Malignant Teratoma of Ovary 12 58
Ovarian Malignant Teratoma 58
Ovarian Immature Teratoma 58

Characteristics:

Orphanet epidemiological data:

58
malignant teratoma of ovary
Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:6331
NCIt 49 C8111
ICD10 via Orphanet 33 C56
Orphanet 58 ORPHA398987
UMLS 71 C0346182

Summaries for Immature Teratoma of Ovary

Disease Ontology : 12 A malignant ovarian germ cell neoplasm that is a teratoma containing variable amounts of immature (typically primitive/embryonal neuroectodermal) tissues, including, in its most primitive forms, embryoid bodies.

MalaCards based summary : Immature Teratoma of Ovary, also known as malignant teratoma of ovary, is related to ovarian germ cell teratoma and testicular yolk sac tumor. An important gene associated with Immature Teratoma of Ovary is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are Aldosterone synthesis and secretion and FOXA2 and FOXA3 transcription factor networks. The drugs Ribavirin and Palivizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and colon, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Immature Teratoma of Ovary

Diseases related to Immature Teratoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 ovarian germ cell teratoma 30.4 TG AFP
2 testicular yolk sac tumor 29.9 TTR AFP
3 teratoma 29.8 KRAS CEACAM5 AFP
4 mature teratoma 29.8 KRAS CEACAM5 AFP
5 malignant teratoma 29.8 CEACAM5 AFP
6 ovarian germ cell cancer 29.6 TG CEACAM5 AFP
7 cystic teratoma 29.6 KRAS CEACAM5 AFP
8 childhood immature teratoma of ovary 12.6
9 germ cells tumors 10.5
10 teratoma, ovarian 10.4
11 germ cell cancer 10.4
12 signet ring basal cell carcinoma 10.2 KRAS CEACAM5
13 breast cystic hypersecretory carcinoma 10.2 TG CEACAM5
14 apocrine adenoma 10.2 KRAS CEACAM5
15 papillary thymic adenocarcinoma 10.2 TG CEACAM5
16 descending colon cancer 10.2 KRAS CEACAM5
17 transverse colon cancer 10.2 KRAS CEACAM5
18 endodermal sinus tumor 10.2
19 glioblastoma multiforme 10.2
20 appendiceal neoplasm 10.2 KRAS CEACAM5
21 eccrine papillary adenoma 10.2 KRAS CEACAM5
22 appendix adenocarcinoma 10.2 KRAS CEACAM5
23 ascending colon cancer 10.1 KRAS CEACAM5
24 biliary tract benign neoplasm 10.1 KRAS CEACAM5
25 ovarian mucinous neoplasm 10.1 KRAS CEACAM5
26 iodine hypothyroidism 10.1 TG DDX41
27 thyroid angiosarcoma 10.1 TG CEACAM5
28 nasal cavity olfactory neuroblastoma 10.1 TG CEACAM5
29 appendix disease 10.1 KRAS CEACAM5
30 appendix cancer 10.1 KRAS CEACAM5
31 rectosigmoid cancer 10.1 KRAS CEACAM5
32 anus cancer 10.1 KRAS CEACAM5
33 duodenum disease 10.1 KRAS CEACAM5
34 duodenum cancer 10.1 KRAS CEACAM5
35 papillary serous adenocarcinoma 10.1 KRAS CEACAM5
36 thyroid gland medullary carcinoma 10.1 TG CEACAM5
37 cecum carcinoma 10.1 KRAS CEACAM5
38 chest wall lipoma 10.1 TTR CEACAM5
39 villous adenoma 10.1 KRAS CEACAM5
40 pseudomyxoma peritonei 10.1 KRAS CEACAM5
41 adenocarcinoma in situ 10.1 KRAS CEACAM5
42 rectum adenocarcinoma 10.1 KRAS CEACAM5
43 signet ring cell adenocarcinoma 10.1 KRAS CEACAM5
44 thyroid gland follicular carcinoma 10.1 TG CEACAM5
45 reproductive organ benign neoplasm 10.1 KRAS CEACAM5
46 bronchiolo-alveolar adenocarcinoma 10.1 KRAS CEACAM5
47 ovarian cystadenocarcinoma 10.1 KRAS CEACAM5
48 large intestine lipoma 10.0 TTR CEACAM5
49 lipoma of colon 10.0 TTR CEACAM5
50 colonic benign neoplasm 10.0 KRAS CEACAM5

Graphical network of the top 20 diseases related to Immature Teratoma of Ovary:



Diseases related to Immature Teratoma of Ovary

Symptoms & Phenotypes for Immature Teratoma of Ovary

GenomeRNAi Phenotypes related to Immature Teratoma of Ovary according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.86 KRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.86 AFP KRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.86 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.86 KRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.86 KRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.86 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.86 KRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.86 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.86 KRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.86 AFP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.86 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.86 AFP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.86 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.86 AFP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.86 AFP
16 Reduced mammosphere formation GR00396-S 8.92 AFP DDX41 KRAS TTR

Drugs & Therapeutics for Immature Teratoma of Ovary

Drugs for Immature Teratoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 3 36791-04-5 37542
2
Palivizumab Approved, Investigational Phase 3 188039-54-5
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Captopril Approved Phase 3 62571-86-2 44093
5
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
6
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
10
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
11
Etoposide Approved Phase 3 33419-42-0 36462
12
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
13
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
14 Alkylating Agents Phase 3
15 Antibodies, Monoclonal Phase 3
16 Antiviral Agents Phase 3
17 Immunoglobulins Phase 3
18 Antibodies Phase 3
19 Antimetabolites Phase 3
20 Anti-Infective Agents Phase 3
21 Hormone Antagonists Phase 3
22 Immunosuppressive Agents Phase 3
23 Hormones Phase 3
24 Immunologic Factors Phase 3
25
protease inhibitors Phase 3
26 Antihypertensive Agents Phase 3
27 HIV Protease Inhibitors Phase 3
28 Antirheumatic Agents Phase 3
29 Angiotensin-Converting Enzyme Inhibitors Phase 3
30 Cytochrome P-450 CYP3A Inhibitors Phase 3
31 Cytochrome P-450 Enzyme Inhibitors Phase 3
32
Hydroxyitraconazole Phase 3
33 Antifungal Agents Phase 3
34 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
35 Steroid Synthesis Inhibitors Phase 3
36 Antiparasitic Agents Phase 3
37 Liposomal amphotericin B Phase 3
38 Antiprotozoal Agents Phase 3
39 Topoisomerase Inhibitors Phase 3
40 Etoposide phosphate Phase 3
41 Anti-Bacterial Agents Phase 3
42 Antibiotics, Antitubercular Phase 3
43 Podophyllotoxin Phase 3 518-28-5
44
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
45
Ifosfamide Approved Phase 2 3778-73-2 3690
46
Lenograstim Approved, Investigational Phase 2 135968-09-1
47
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
48
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
49
Oprelvekin Approved, Investigational Phase 2 145941-26-0
50
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
2 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
6 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
7 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
8 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
9 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
11 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
12 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
13 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
14 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
15 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
16 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
17 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465

Search NIH Clinical Center for Immature Teratoma of Ovary

Genetic Tests for Immature Teratoma of Ovary

Anatomical Context for Immature Teratoma of Ovary

MalaCards organs/tissues related to Immature Teratoma of Ovary:

40
Ovary, Thyroid, Colon, Bone, Bone Marrow, Liver, Appendix

Publications for Immature Teratoma of Ovary

Articles related to Immature Teratoma of Ovary:

# Title Authors PMID Year
1
Growing Teratoma Syndrome Following Treatment for Immature Teratoma of Ovary-A Case Report and Review of Literature. 61
28706371 2017
2
Gliomatosis Peritonei Arising in Setting of Immature Teratoma of Ovary: A Case Report and Review of Literature. 61
27298531 2016
3
Immature teratoma of ovary--outcome following primary and secondary surgery: study of a single institution cohort. 61
26142911 2015
4
Ovarian immature teratoma during pregnancy: a case report. 61
25807726 2014
5
Immature teratoma of ovary composed largely of choroid plexus. 61
20683425 2010
6
Identification of two different surface epitopes of human ovarian epithelial carcinomas by monoclonal antibodies. 61
2580620 1985
7
SOLID MALIGNANT TERATOMA OF OVARY WITH EMBRYONAL CARCINOMA. 61
14134285 1963

Variations for Immature Teratoma of Ovary

Expression for Immature Teratoma of Ovary

Search GEO for disease gene expression data for Immature Teratoma of Ovary.

Pathways for Immature Teratoma of Ovary

Pathways related to Immature Teratoma of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 TTR TG KRAS
2 10.27 TTR AFP

GO Terms for Immature Teratoma of Ovary

Sources for Immature Teratoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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