MCID: IMM001
MIFTS: 38

Immune-Complex Glomerulonephritis

Categories: Nephrological diseases, Immune diseases

Aliases & Classifications for Immune-Complex Glomerulonephritis

MalaCards integrated aliases for Immune-Complex Glomerulonephritis:

Name: Immune-Complex Glomerulonephritis 12 15 73
Immune Complex Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4784
NCIt 50 C35800
SNOMED-CT 68 123752003
UMLS 73 C0744421

Summaries for Immune-Complex Glomerulonephritis

MalaCards based summary : Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to vasculitis and cytomegalovirus infection. An important gene associated with Immune-Complex Glomerulonephritis is SELP (Selectin P), and among its related pathways/superpathways are Innate Immune System and Cell adhesion molecules (CAMs). Affiliated tissues include kidney, neutrophil and t cells, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Immune-Complex Glomerulonephritis

Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.0 ICAM1 MPO VCAM1
2 cytomegalovirus infection 29.9 ICAM1 VCAM1
3 complement factor i deficiency 29.8 C4B CFI
4 glomerulonephritis 28.0 C4B CFI ICAM1 MPO TLR9 VCAM1
5 maxillary sinusitis 10.6 MPO SELP
6 rapidly progressive glomerulonephritis 10.4 ICAM1 MPO
7 acute proliferative glomerulonephritis 10.4 ICAM1 MPO
8 lymphocytic vasculitis 10.3 ICAM1 VCAM1
9 cortical thymoma 10.3 ICAM1 VCAM1
10 mooren's ulcer 10.3 ICAM1 VCAM1
11 pleurisy 10.3 ICAM1 MPO
12 subendocardial myocardial infarction 10.3 ICAM1 VCAM1
13 actinic prurigo 10.3 ICAM1 VCAM1
14 rheumatoid vasculitis 10.2 ICAM1 VCAM1
15 limbal stem cell deficiency 10.2 ICAM1 VCAM1
16 shwartzman phenomenon 10.2 ICAM1 VCAM1
17 dengue disease 10.1 ICAM1 VCAM1
18 peripheral artery disease 10.1 SELP VCAM1
19 ischemia 10.1 ICAM1 MPO SELP
20 leukemia 10.1
21 primary progressive multiple sclerosis 10.0 ICAM1 VCAM1
22 arteriosclerosis obliterans 10.0 ICAM1 SELP VCAM1
23 mucocutaneous leishmaniasis 10.0 CCR5 TLR9
24 chronic venous insufficiency 10.0 ICAM1 SELP VCAM1
25 hepatitis 10.0
26 endocarditis 10.0
27 nephrotic syndrome 10.0
28 proliferative glomerulonephritis 10.0
29 retroperitoneal fibrosis 10.0
30 venous insufficiency 10.0 ICAM1 SELP VCAM1
31 arteriosclerosis 10.0 ICAM1 SELP VCAM1
32 cerebrovascular disease 10.0 ICAM1 SELP VCAM1
33 oral lichen planus 9.9 CCR5 ICAM1 VCAM1
34 henoch-schoenlein purpura 9.9 ICAM1 MPO VCAM1
35 leukostasis 9.9 ICAM1 MPO VCAM1
36 diabetes mellitus 9.9
37 thrombocytopenia 9.9
38 hepatitis c 9.9
39 thyroiditis 9.9
40 amyloidosis 9.9
41 plague 9.9 CCR5 TLR9
42 allergic rhinitis 9.9 ICAM1 MPO VCAM1
43 yellow fever 9.9 CCR5 TLR9
44 post-thrombotic syndrome 9.8 ICAM1 TLR9
45 sickle cell disease 9.8 SELP VCAM1
46 lichen disease 9.8 ICAM1 TLR9
47 hypersensitivity reaction type iii disease 9.8 C4B ICAM1 MPO
48 renal cell carcinoma, nonpapillary 9.8
49 myositis 9.8
50 porokeratosis 1, multiple types 9.8

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to Immune-Complex Glomerulonephritis

Symptoms & Phenotypes for Immune-Complex Glomerulonephritis

MGI Mouse Phenotypes related to Immune-Complex Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CCR5 SELP CFI TLR9 FTH1 C4B
2 cardiovascular system MP:0005385 10.06 MPO CCR5 SELP FTH1 C4B ICAM1
3 homeostasis/metabolism MP:0005376 10.02 CCR5 SELP CFI FTH1 C4B ICAM1
4 cellular MP:0005384 9.98 CCR5 SELP FTH1 ICAM1 CCR1 TLR9
5 immune system MP:0005387 9.91 CCR5 SELP FTH1 C4B ICAM1 CCR1
6 digestive/alimentary MP:0005381 9.8 CCR1 CCR5 C4B ICAM1 TLR9
7 mortality/aging MP:0010768 9.61 MPO CCR5 SELP FTH1 C4B ICAM1
8 liver/biliary system MP:0005370 9.55 CCR5 SELP FTH1 C4B CCR1
9 renal/urinary system MP:0005367 9.02 SELP CFI C4B CCR1 TLR9

Drugs & Therapeutics for Immune-Complex Glomerulonephritis

Search Clinical Trials , NIH Clinical Center for Immune-Complex Glomerulonephritis

Genetic Tests for Immune-Complex Glomerulonephritis

Anatomical Context for Immune-Complex Glomerulonephritis

MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

41
Kidney, Neutrophil, T Cells, Bone, Bone Marrow, Monocytes, Thyroid

Publications for Immune-Complex Glomerulonephritis

Articles related to Immune-Complex Glomerulonephritis:

(show top 50) (show all 252)
# Title Authors Year
1
Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves. ( 29628480 )
2018
2
The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis. ( 29395335 )
2018
3
Panitumumab-Induced Immune Complex Glomerulonephritis. ( 27765383 )
2017
4
The effects of Salvia przewalskii total phenolic acid extract on immune complex glomerulonephritis. ( 29025319 )
2017
5
Vanillic Acid Ameliorates Cationic Bovine Serum Albumin Induced Immune Complex Glomerulonephritis in BALB/c Mice. ( 27130149 )
2016
6
Severe acute kidney injury in children owing to infective endocarditis-associated immune complex glomerulonephritis: a report of two cases. ( 27077635 )
2016
7
Levamisole/Cocaine Induced Systemic Vasculitis and Immune Complex Glomerulonephritis. ( 26290761 )
2015
8
Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. ( 26043977 )
2015
9
Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. ( 26166765 )
2015
10
Non-immunoglobulin A mesangial immune complex glomerulonephritis in kidney transplants. ( 26245687 )
2015
11
CD11b is protective in complement-mediated immune complex glomerulonephritis. ( 25565310 )
2015
12
The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms. ( 24805106 )
2014
13
Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation. ( 23481367 )
2013
14
Tocilizumab-induced immune complex glomerulonephritis in a patient with rheumatoid arthritis. ( 23325036 )
2013
15
The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. ( 22832515 )
2012
16
Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis. ( 23207123 )
2012
17
Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis. ( 23064186 )
2012
18
HIV-associated immune complex glomerulonephritis with "lupus-like" features. ( 21743226 )
2011
19
Familial C4B deficiency and immune complex glomerulonephritis. ( 20580617 )
2010
20
Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. ( 19740350 )
2009
21
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. ( 19158348 )
2009
22
Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis. ( 17991287 )
2008
23
Cryoglobulinaemia type III with severe neuropathy and immune complex glomerulonephritis: remission after plasmapheresis and rituximab. ( 17924113 )
2008
24
Immune complex glomerulonephritis following bone marrow transplantation in C3 deficient mice. ( 18836527 )
2008
25
An immune-complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha (Walbaum). ( 18752546 )
2008
26
Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis. ( 17544622 )
2007
27
Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. ( 17259999 )
2007
28
Mesangial immune complex glomerulonephritis due to complement factor D deficiency. ( 17410102 )
2007
29
Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis. ( 17464766 )
2007
30
IgM-immune complex glomerulonephritis associated with sarcoidosis. ( 16544180 )
2006
31
Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis. ( 16526313 )
2006
32
CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis. ( 16920982 )
2006
33
Toll-like receptor-7 modulates immune complex glomerulonephritis. ( 16280469 )
2006
34
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. ( 16954173 )
2006
35
HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases. ( 15780090 )
2005
36
Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. ( 15755760 )
2005
37
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis. ( 16138437 )
2005
38
Treatment of experimental immune complex glomerulonephritis by sodium alginate. ( 15893960 )
2005
39
The role of complement in cryoglobulin-induced immune complex glomerulonephritis. ( 16272350 )
2005
40
Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury. ( 15696187 )
2005
41
C3 is central to the interstitial component of experimental immune complex glomerulonephritis. ( 15870025 )
2005
42
Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis. ( 14675039 )
2004
43
Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. ( 12538732 )
2003
44
C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. ( 12296852 )
2002
45
Retroperitoneal fibrosis and immune-complex glomerulonephritis. ( 11393386 )
2001
46
Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. ( 11316850 )
2001
47
Novel therapeutic approach by culture filtrate of Cryptococcus neoformans var. gattii (CneF) in experimental immune complex glomerulonephritis. ( 11368886 )
2000
48
Immune complex glomerulonephritis in patients with hepatitis C. ( 18209331 )
2000
49
A syndrome of immune complex glomerulonephritis and ophthalmic abnormalities. ( 10465118 )
1999
50
Ureteral obstruction reverses glomerular proliferation in immune complex glomerulonephritis. ( 10072261 )
1999

Variations for Immune-Complex Glomerulonephritis

Expression for Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for Immune-Complex Glomerulonephritis

GO Terms for Immune-Complex Glomerulonephritis

Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 C4B CFI ICAM1 MPO SELP TLR9
2 external side of plasma membrane GO:0009897 9.02 CCR1 CCR5 ICAM1 SELP VCAM1

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.78 CCR1 ICAM1 SELP VCAM1
2 cytokine-mediated signaling pathway GO:0019221 9.67 CCR1 CCR5 ICAM1 VCAM1
3 calcium-mediated signaling using intracellular calcium source GO:0035584 9.46 SELP VCAM1
4 response to lipopolysaccharide GO:0032496 9.46 ICAM1 MPO SELP VCAM1
5 dendritic cell chemotaxis GO:0002407 9.43 CCR1 CCR5
6 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 ICAM1 SELP VCAM1
7 leukocyte tethering or rolling GO:0050901 9.4 SELP VCAM1
8 inflammatory response GO:0006954 9.35 C4B CCR1 CCR5 SELP TLR9
9 membrane to membrane docking GO:0022614 9.32 ICAM1 VCAM1
10 leukocyte cell-cell adhesion GO:0007159 8.8 ICAM1 SELP VCAM1

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phospholipase C activity GO:0004435 9.32 CCR1 CCR5
2 chemokine receptor activity GO:0004950 9.26 CCR1 CCR5
3 C-C chemokine receptor activity GO:0016493 9.16 CCR1 CCR5
4 C-C chemokine binding GO:0019957 8.96 CCR1 CCR5
5 chemokine (C-C motif) ligand 5 binding GO:0071791 8.62 CCR1 CCR5

Sources for Immune-Complex Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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