MCID: IMM001
MIFTS: 42

Immune-Complex Glomerulonephritis

Categories: Immune diseases, Nephrological diseases

Aliases & Classifications for Immune-Complex Glomerulonephritis

MalaCards integrated aliases for Immune-Complex Glomerulonephritis:

Name: Immune-Complex Glomerulonephritis 12 15 73
Immune Complex Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4784
NCIt 50 C35800
UMLS 73 C0744421

Summaries for Immune-Complex Glomerulonephritis

MalaCards based summary : Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to glomerulonephritis and complement factor i deficiency. An important gene associated with Immune-Complex Glomerulonephritis is SELP (Selectin P), and among its related pathways/superpathways are Innate Immune System and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. Affiliated tissues include kidney, bone and neutrophil, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Immune-Complex Glomerulonephritis

Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 30.5 C4B CFI ICAM1 MPO TLR9 VCAM1
2 complement factor i deficiency 30.0 C4B CFI
3 vasculitis 29.9 CFI ICAM1 MPO VCAM1
4 mesangial proliferative glomerulonephritis 10.2 CCR1 CCR5
5 maxillary sinusitis 10.1 MPO SELP
6 hepatitis 10.1
7 leukemia 10.1
8 endocarditis 10.1
9 nephrotic syndrome 10.1
10 proliferative glomerulonephritis 10.1
11 retroperitoneal fibrosis 10.1
12 acute proliferative glomerulonephritis 10.1 ICAM1 MPO
13 grange syndrome 10.1 SELP VCAM1
14 rapidly progressive glomerulonephritis 10.1 ICAM1 MPO
15 lymphocytic vasculitis 10.1 ICAM1 VCAM1
16 cortical thymoma 10.0 ICAM1 VCAM1
17 mooren's ulcer 10.0 ICAM1 VCAM1
18 shwartzman phenomenon 10.0 ICAM1 VCAM1
19 subendocardial myocardial infarction 10.0 ICAM1 VCAM1
20 pollen allergy 10.0 ICAM1 MPO
21 diabetes mellitus 10.0
22 thrombocytopenia 10.0
23 hepatitis c 10.0
24 mixed connective tissue disease 10.0
25 connective tissue disease 10.0
26 amyloidosis 10.0
27 actinic prurigo 10.0 ICAM1 VCAM1
28 brachydactyly, type e2 10.0 ICAM1 VCAM1
29 rheumatoid vasculitis 10.0 ICAM1 VCAM1
30 limbal stem cell deficiency 10.0 ICAM1 VCAM1
31 peripheral artery disease 10.0 SELP VCAM1
32 pleurisy 10.0 ICAM1 MPO
33 ocular toxoplasmosis 10.0 CCR5 TLR9
34 mucocutaneous leishmaniasis 10.0 CCR5 TLR9
35 goodpasture syndrome 10.0 MPO VCAM1
36 dengue disease 10.0 ICAM1 VCAM1
37 autoimmune glomerulonephritis 10.0 ICAM1 TLR9
38 ischemia 10.0 ICAM1 MPO SELP
39 arteriosclerosis 10.0 ICAM1 SELP VCAM1
40 arteriosclerosis obliterans 9.9 ICAM1 SELP VCAM1
41 chronic venous insufficiency 9.9 ICAM1 SELP VCAM1
42 venous insufficiency 9.9 ICAM1 SELP VCAM1
43 sickle cell disease 9.9 SELP VCAM1
44 cerebrovascular disease 9.9 ICAM1 SELP VCAM1
45 post-thrombotic syndrome 9.9 ICAM1 TLR9
46 yellow fever 9.9 CCR5 TLR9
47 oral lichen planus 9.9 CCR5 ICAM1 VCAM1
48 lichen disease 9.9 ICAM1 TLR9
49 extrinsic cardiomyopathy 9.9 ICAM1 TLR9
50 primary progressive multiple sclerosis 9.9 ICAM1 VCAM1

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to Immune-Complex Glomerulonephritis

Symptoms & Phenotypes for Immune-Complex Glomerulonephritis

MGI Mouse Phenotypes related to Immune-Complex Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 C4B CCR1 CCR5 CFI FTH1 ICAM1
2 cardiovascular system MP:0005385 10.06 C4B CCR1 CCR5 FTH1 ICAM1 MPO
3 homeostasis/metabolism MP:0005376 10.02 C4B CCR1 CCR5 CFI FTH1 ICAM1
4 cellular MP:0005384 9.98 CCR1 CCR5 FTH1 ICAM1 SELP TLR9
5 immune system MP:0005387 9.91 C4B CCR1 CCR5 FTH1 ICAM1 MPO
6 digestive/alimentary MP:0005381 9.8 C4B CCR1 CCR5 ICAM1 TLR9
7 mortality/aging MP:0010768 9.61 C4B CCR1 CCR5 FTH1 ICAM1 MPO
8 liver/biliary system MP:0005370 9.55 C4B CCR1 CCR5 FTH1 SELP
9 renal/urinary system MP:0005367 9.02 C4B CCR1 CFI SELP TLR9

Drugs & Therapeutics for Immune-Complex Glomerulonephritis

Search Clinical Trials , NIH Clinical Center for Immune-Complex Glomerulonephritis

Genetic Tests for Immune-Complex Glomerulonephritis

Anatomical Context for Immune-Complex Glomerulonephritis

MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

41
Kidney, Bone, Neutrophil, T Cells, Bone Marrow, Liver, Thyroid

Publications for Immune-Complex Glomerulonephritis

Articles related to Immune-Complex Glomerulonephritis:

(show top 50) (show all 255)
# Title Authors Year
1
Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves. ( 29628480 )
2018
2
The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis. ( 29395335 )
2018
3
Panitumumab-Induced Immune Complex Glomerulonephritis. ( 27765383 )
2017
4
The effects of Salvia przewalskii total phenolic acid extract on immune complex glomerulonephritis. ( 29025319 )
2017
5
Vanillic Acid Ameliorates Cationic Bovine Serum Albumin Induced Immune Complex Glomerulonephritis in BALB/c Mice. ( 27130149 )
2016
6
Severe acute kidney injury in children owing to infective endocarditis-associated immune complex glomerulonephritis: a report of two cases. ( 27077635 )
2016
7
Levamisole/Cocaine Induced Systemic Vasculitis and Immune Complex Glomerulonephritis. ( 26290761 )
2015
8
Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. ( 26043977 )
2015
9
Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. ( 26166765 )
2015
10
Non-immunoglobulin A mesangial immune complex glomerulonephritis in kidney transplants. ( 26245687 )
2015
11
CD11b is protective in complement-mediated immune complex glomerulonephritis. ( 25565310 )
2015
12
The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms. ( 24805106 )
2014
13
Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation. ( 23481367 )
2013
14
Tocilizumab-induced immune complex glomerulonephritis in a patient with rheumatoid arthritis. ( 23325036 )
2013
15
The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. ( 22832515 )
2012
16
Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis. ( 23207123 )
2012
17
Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis. ( 23064186 )
2012
18
HIV-associated immune complex glomerulonephritis with "lupus-like" features. ( 21743226 )
2011
19
Familial C4B deficiency and immune complex glomerulonephritis. ( 20580617 )
2010
20
Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. ( 19740350 )
2009
21
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. ( 19158348 )
2009
22
Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis. ( 17991287 )
2008
23
Cryoglobulinaemia type III with severe neuropathy and immune complex glomerulonephritis: remission after plasmapheresis and rituximab. ( 17924113 )
2008
24
Immune complex glomerulonephritis following bone marrow transplantation in C3 deficient mice. ( 18836527 )
2008
25
An immune-complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha (Walbaum). ( 18752546 )
2008
26
Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis. ( 17544622 )
2007
27
Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. ( 17259999 )
2007
28
Mesangial immune complex glomerulonephritis due to complement factor D deficiency. ( 17410102 )
2007
29
Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis. ( 17464766 )
2007
30
IgM-immune complex glomerulonephritis associated with sarcoidosis. ( 16544180 )
2006
31
Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis. ( 16526313 )
2006
32
CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis. ( 16920982 )
2006
33
Toll-like receptor-7 modulates immune complex glomerulonephritis. ( 16280469 )
2006
34
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. ( 16954173 )
2006
35
HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases. ( 15780090 )
2005
36
Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. ( 15755760 )
2005
37
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis. ( 16138437 )
2005
38
Treatment of experimental immune complex glomerulonephritis by sodium alginate. ( 15893960 )
2005
39
The role of complement in cryoglobulin-induced immune complex glomerulonephritis. ( 16272350 )
2005
40
Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury. ( 15696187 )
2005
41
C3 is central to the interstitial component of experimental immune complex glomerulonephritis. ( 15870025 )
2005
42
Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis. ( 14675039 )
2004
43
Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. ( 12538732 )
2003
44
C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. ( 12296852 )
2002
45
Retroperitoneal fibrosis and immune-complex glomerulonephritis. ( 11393386 )
2001
46
Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. ( 11316850 )
2001
47
Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice. ( 11342671 )
2001
48
Novel therapeutic approach by culture filtrate of Cryptococcus neoformans var. gattii (CneF) in experimental immune complex glomerulonephritis. ( 11368886 )
2000
49
Immune complex glomerulonephritis in patients with hepatitis C. ( 18209331 )
2000
50
A syndrome of immune complex glomerulonephritis and ophthalmic abnormalities. ( 10465118 )
1999

Variations for Immune-Complex Glomerulonephritis

Expression for Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for Immune-Complex Glomerulonephritis

GO Terms for Immune-Complex Glomerulonephritis

Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.65 CCR1 CCR5 ICAM1 SELP VCAM1
2 extracellular exosome GO:0070062 9.63 C4B CFI FTH1 ICAM1 MPO VCAM1
3 extracellular space GO:0005615 9.43 C4B CFI ICAM1 MPO SELP VCAM1
4 external side of plasma membrane GO:0009897 9.02 CCR1 CCR5 ICAM1 SELP VCAM1

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.81 CCR1 ICAM1 SELP VCAM1
2 immune response GO:0006955 9.78 CCR1 CCR5 FTH1 TLR9
3 cytokine-mediated signaling pathway GO:0019221 9.67 CCR1 CCR5 ICAM1 VCAM1
4 cell chemotaxis GO:0060326 9.58 CCR1 CCR5 VCAM1
5 response to ionizing radiation GO:0010212 9.52 ICAM1 VCAM1
6 calcium-mediated signaling using intracellular calcium source GO:0035584 9.49 SELP VCAM1
7 leukocyte tethering or rolling GO:0050901 9.46 SELP VCAM1
8 response to lipopolysaccharide GO:0032496 9.46 ICAM1 MPO SELP VCAM1
9 dendritic cell chemotaxis GO:0002407 9.43 CCR1 CCR5
10 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 ICAM1 SELP VCAM1
11 inflammatory response GO:0006954 9.35 C4B CCR1 CCR5 SELP TLR9
12 membrane to membrane docking GO:0022614 9.32 ICAM1 VCAM1
13 leukocyte cell-cell adhesion GO:0007159 8.8 ICAM1 SELP VCAM1

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phospholipase C activity GO:0004435 9.37 CCR1 CCR5
2 chemokine binding GO:0019956 9.32 CCR1 CCR5
3 C-C chemokine binding GO:0019957 9.26 CCR1 CCR5
4 C-C chemokine receptor activity GO:0016493 9.16 CCR1 CCR5
5 chemokine receptor activity GO:0004950 8.96 CCR1 CCR5
6 chemokine (C-C motif) ligand 5 binding GO:0071791 8.62 CCR1 CCR5

Sources for Immune-Complex Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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