MCID: IMM001
MIFTS: 36

Immune-Complex Glomerulonephritis

Categories: Immune diseases, Nephrological diseases

Aliases & Classifications for Immune-Complex Glomerulonephritis

MalaCards integrated aliases for Immune-Complex Glomerulonephritis:

Name: Immune-Complex Glomerulonephritis 12 15 70
Immune Complex Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4784
NCIt 50 C35800
SNOMED-CT 67 123752003
UMLS 70 C0744421

Summaries for Immune-Complex Glomerulonephritis

MalaCards based summary : Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to proliferative glomerulonephritis and mesangial proliferative glomerulonephritis. An important gene associated with Immune-Complex Glomerulonephritis is C4B (Complement C4B (Chido Blood Group)), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. Affiliated tissues include kidney, t cells and bone marrow, and related phenotypes are cardiovascular system and cellular

Related Diseases for Immune-Complex Glomerulonephritis

Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 403)
# Related Disease Score Top Affiliating Genes
1 proliferative glomerulonephritis 31.1 MPO CCR5 C3
2 mesangial proliferative glomerulonephritis 30.9 CFHR2 CCR5 CCR1
3 glomerulonephritis 30.6 VCAM1 MPO ITGAL ICAM1 CFI C4B
4 membranous nephropathy 30.4 MPO C3 ALB
5 crescentic glomerulonephritis 30.3 VCAM1 MPO ICAM1 CCR5
6 vasculitis 30.3 VCAM1 SELP MPO ICAM1 C3
7 membranoproliferative glomerulonephritis 30.0 ITGAL ICAM1 CFHR2 C3 ALB
8 complement factor i deficiency 30.0 CFI C4B C3
9 rapidly progressive glomerulonephritis 29.9 MPO ICAM1 C3 ALB
10 erythema nodosum 29.9 VCAM1 ICAM1 C3
11 sarcoidosis 1 29.8 ICOSLG ICAM1 CD4 CCR5
12 exanthem 29.7 ICOSLG H2AC18 CD4 ALB
13 complement deficiency 29.7 CFI CFHR2 C4B C3
14 afibrinogenemia, congenital 29.7 CFI CFHR2 C4B C3
15 iga glomerulonephritis 29.7 ICAM1 CFHR2 C3 ALB
16 bacterial infectious disease 29.7 ICOSLG H2AC18 CFHR2 CD4
17 rheumatoid arthritis 29.6 VCAM1 MPO ITGAL ICAM1 CCR5 CCR1
18 klebsiella pneumonia 29.5 ICOSLG H2AC18 CD4 ALB
19 meningitis 29.5 ICAM1 CFI C3 ALB
20 celiac disease 1 29.4 ICOSLG H2AC18 CD4 ALB
21 crohn's disease 29.4 MPO ICOSLG ICAM1 CD4 ALB
22 goodpasture syndrome 29.4 VCAM1 MPO H2AC18 CD4 ALB
23 connective tissue disease 29.4 ICOSLG H2AC18 CFHR2 CD4 ALB
24 autoimmune disease 29.4 VCAM1 MPO ITGAL ICOSLG CCR5 C3
25 acute proliferative glomerulonephritis 29.1 MPO ICOSLG CD4 C3 ALB
26 thrombocytopenia 29.1 TLR7 SELP ITGAL ICAM1 CFI C3
27 systemic lupus erythematosus 26.6 VCAM1 TLR7 SELP MPO ITGAL ICOSLG
28 proteinuria, chronic benign 10.7
29 nephrotic syndrome 10.5
30 glomerular disease 10.4
31 autoimmune enteropathy 10.3 ITGAL ICAM1
32 cryoglobulinemia 10.3
33 submandibular gland cancer 10.3 CCR5 CCR1
34 venous insufficiency 10.3 VCAM1 SELP ICAM1
35 actinic prurigo 10.3 VCAM1 ITGAL ICAM1
36 mooren's ulcer 10.3 VCAM1 ITGAL ICAM1
37 arteriosclerosis obliterans 10.3 VCAM1 SELP ICAM1
38 diffuse infiltrative lymphocytosis syndrome 10.3 ITGAL CD4
39 rheumatoid vasculitis 10.3 VCAM1 ICAM1
40 endocarditis 10.3
41 shwartzman phenomenon 10.2 VCAM1 ICAM1
42 pulmonary sarcoidosis 10.2 ITGAL ICAM1 CCR5
43 oral lichen planus 10.2 VCAM1 ICAM1 CCR5
44 abacavir allergy 10.2 CD4 CCR5
45 peripheral artery disease 10.2 VCAM1 SELP ICAM1
46 kidney cortex necrosis 10.2 H2AC18 CFI
47 autoimmune atherosclerosis 10.2 VCAM1 CD4
48 primary progressive multiple sclerosis 10.2 VCAM1 ITGAL ICAM1
49 heterophyiasis 10.2 ICAM1 ALB
50 infective endocarditis 10.2

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to Immune-Complex Glomerulonephritis

Symptoms & Phenotypes for Immune-Complex Glomerulonephritis

MGI Mouse Phenotypes related to Immune-Complex Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ALB C3 C4B CCR1 CCR5 FTH1
2 cellular MP:0005384 10 ALB C3 CCR1 CCR5 CD4 FTH1
3 hematopoietic system MP:0005397 9.97 C3 C4B CCR1 CCR5 CD4 CFI
4 homeostasis/metabolism MP:0005376 9.8 ALB C3 C4B CCR1 CCR5 CD4
5 immune system MP:0005387 9.47 ALB C3 C4B CCR1 CCR5 CD4

Drugs & Therapeutics for Immune-Complex Glomerulonephritis

Search Clinical Trials , NIH Clinical Center for Immune-Complex Glomerulonephritis

Genetic Tests for Immune-Complex Glomerulonephritis

Anatomical Context for Immune-Complex Glomerulonephritis

MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

40
Kidney, T Cells, Bone Marrow, Bone, Heart, Skin, Eye

Publications for Immune-Complex Glomerulonephritis

Articles related to Immune-Complex Glomerulonephritis:

(show top 50) (show all 702)
# Title Authors PMID Year
1
Immune-complex glomerulonephritis following COVID-19 infection. 61
33615049 2021
2
Complement-mediated kidney diseases. 61
33137606 2020
3
Clinicopathologic and pathologic characteristics of feline proteinuric kidney disease. 61
32456516 2020
4
Catching the Worm Early: An Atypical Case of Bancroftian Filarial Nephropathy. 61
33229775 2020
5
Immune-complex glomerulonephritis with a membranoproliferative pattern in Frasier syndrome: a case report and review of the literature. 61
32838737 2020
6
The role of programed death-ligand 1 in renal diseases. 61
32122188 2020
7
Resolution of IgA and C3 immune deposits in Staphylococcus infection-associated glomerulonephritis in a kidney transplant recipient
. 61
32567542 2020
8
Podocytes Intracytoplasmic Dense Inclusions: Are They Associated with Subepithelial Dense Deposits? An Ultrastructural Study. 61
33282687 2020
9
The spectrum of kidney biopsy findings in HIV-infected patients in the modern era. 61
32278618 2020
10
The glomerular crescent: triggers, evolution, resolution, and implications for therapy. 61
32132388 2020
11
Complement and the Kidney: An Overview. 61
32553250 2020
12
[Infections-associated Glomerulonephritis]. 61
32069491 2020
13
Epstein-Barr Functional Mimicry: Pathogenicity of Oncogenic Latent Membrane Protein-1 in Systemic Lupus Erythematosus and Autoimmunity. 61
33613527 2020
14
STK4 Deficiency in a Patient with Immune Complex Glomerulonephritis, Salt-Losing Tubulopathy, and Castleman's-Like Disease. 61
31444685 2019
15
Occurrence, management and outcome of immune-complex glomerulonephritis in dogs with suspected glomerulopathy in the UK. 61
31512262 2019
16
MicroRNA-146a-deficient mice develop immune complex glomerulonephritis. 61
31666653 2019
17
Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. 61
31444996 2019
18
Immune-complex glomerulonephritis in cats: a retrospective study based on clinico-pathological data, histopathology and ultrastructural features. 61
31429743 2019
19
Monoclonal immunoglobulin G deposits on tubular basement membrane in renal allograft: is this significant for chronic allograft injury? 61
30124906 2019
20
Clinical and histopathological profile of lupus nephritis and response to treatment with cyclophosphamide: A single center study. 61
31031386 2019
21
Autoantibodies Against C3b-Functional Consequences and Disease Relevance. 61
30761135 2019
22
Exclusive expression of transmembrane TNF aggravates acute glomerulonephritis despite reduced leukocyte infiltration and inflammation. 61
30389199 2019
23
Characteristic morphological changes in anti-VEGF therapy-induced glomerular microangiopathy. 61
30014486 2018
24
Inherited Classical and Alternative Pathway Complement Deficiencies in Children: A Single Center Experience. 61
30593745 2018
25
TLR4+CXCR4+ plasma cells drive nephritis development in systemic lupus erythematosus. 61
29925508 2018
26
Pauci-immune Glomerulonephritis in Systemic Lupus Erythematosus (SLE). 61
30202678 2018
27
Role of Lgals9 Deficiency in Attenuating Nephritis and Arthritis in BALB/c Mice in a Pristane-Induced Lupus Model. 61
29481735 2018
28
Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves. 61
29628480 2018
29
The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis. 61
29395335 2018
30
Toll-like receptors in lupus nephritis. 61
29650017 2018
31
Renal dialysis and long-term treatment of a dog with kidney disease associated with canine leishmaniosis. 61
29554974 2018
32
RIPK3-deficient mice were not protected from nephrotoxic nephritis. 61
29540162 2018
33
Characterization and Etiopathogenic Approach of Pediatric Renal Biopsy Patients in a Colombian Medical Center from 2007-2017. 61
30050696 2018
34
Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy. 61
29666732 2018
35
Acute glomerulonephritis with large confluent IgA-dominant deposits associated with liver cirrhosis. 61
29634718 2018
36
The effects of Salvia przewalskii total phenolic acid extract on immune complex glomerulonephritis. 61
29025319 2017
37
Toll-like receptor activation in the pathogenesis of lupus nephritis. 61
27423476 2017
38
Reprint of "Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis". 61
29111236 2017
39
Frequency of familial Mediterranean fever (MEFV) gene mutations in patients with biopsy-proven primary glomerulonephritis. 61
28573371 2017
40
Tumor necrosis factor superfamily ligand mRNA expression profiles differ between humans and mice during homeostasis and between various murine kidney injuries. 61
28927419 2017
41
Renal effects of immune checkpoint inhibitors. 61
28025384 2017
42
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury. 61
28584258 2017
43
Severe acute kidney injury in children owing to infective endocarditis-associated immune complex glomerulonephritis: a report of two cases. 61
27077635 2017
44
Prolactin has a pathogenic role in systemic lupus erythematosus. 61
28130617 2017
45
Renal biopsy in patients with systemic lupus erythematosus: Not just lupus glomerulonephritis! 61
28277147 2017
46
Panitumumab-Induced Immune Complex Glomerulonephritis. 61
27765383 2017
47
Cathepsins are potential therapeutic targets in kidney disease. 61
27742196 2016
48
Clinicopathologic and Histopathologic Renal Abnormalities in Dogs with Coccidioidomycosis. 61
27717191 2016
49
Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. 61
26166765 2016
50
Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis. 61
27392463 2016

Variations for Immune-Complex Glomerulonephritis

Expression for Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for Immune-Complex Glomerulonephritis

GO Terms for Immune-Complex Glomerulonephritis

Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 VCAM1 SELP MPO ICAM1 CFI C4B
2 cell surface GO:0009986 9.63 VCAM1 ITGAL ICAM1 CD4 CCR5 C3
3 external side of plasma membrane GO:0009897 9.5 VCAM1 SELP ICOSLG ICAM1 CD4 CCR5
4 extracellular exosome GO:0070062 9.4 VCAM1 RPLP2 MPO ITGAL ICOSLG ICAM1

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10 TLR7 ICOSLG CFI CD4 C4B C3
2 viral process GO:0016032 9.96 ITGAL ICAM1 CFI CD4 CCR5
3 cell adhesion GO:0007155 9.91 VCAM1 SELP ITGAL ICAM1 CD4 CCR1
4 regulation of immune response GO:0050776 9.84 VCAM1 ITGAL ICAM1 C3
5 response to lipopolysaccharide GO:0032496 9.78 VCAM1 SELP MPO ICAM1
6 cytokine-mediated signaling pathway GO:0019221 9.77 VCAM1 ICAM1 CD4 CCR5 CCR1
7 immune response GO:0006955 9.73 TLR7 FTH1 CD4 CCR5 CCR1 C3
8 cell chemotaxis GO:0060326 9.72 VCAM1 CCR5 CCR1
9 regulation of complement activation GO:0030449 9.62 CFI CFHR2 C4B C3
10 fusion of virus membrane with host plasma membrane GO:0019064 9.51 CD4 CCR5
11 inflammatory response GO:0006954 9.5 TLR7 SELP ITGAL CCR5 CCR1 C4B
12 positive regulation of apoptotic cell clearance GO:2000427 9.49 C4B C3
13 membrane to membrane docking GO:0022614 9.46 VCAM1 ICAM1
14 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.46 VCAM1 SELP ITGAL ICAM1
15 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.4 ITGAL ICAM1
16 leukocyte cell-cell adhesion GO:0007159 8.92 VCAM1 SELP ITGAL ICAM1

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 ICAM1 CD4 CCR5
2 chemokine (C-C motif) ligand 5 binding GO:0071791 8.62 CCR5 CCR1

Sources for Immune-Complex Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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