MCID: IMM039
MIFTS: 34

Immune Hydrops Fetalis

Categories: Fetal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Immune Hydrops Fetalis

MalaCards integrated aliases for Immune Hydrops Fetalis:

Name: Immune Hydrops Fetalis 60 74
Immune Fetal Hydrops 60
Immune Fetal Edema 60
Immune Hf 60
Ihf 60

Characteristics:

Orphanet epidemiological data:

60
immune hydrops fetalis
Inheritance: Not applicable; Prevalence: 1-5/10000 (United Kingdom); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



External Ids:

ICD10 via Orphanet 35 P56.0
UMLS via Orphanet 75 C0455990
Orphanet 60 ORPHA364013
UMLS 74 C0455990

Summaries for Immune Hydrops Fetalis

MalaCards based summary : Immune Hydrops Fetalis, also known as immune fetal hydrops, is related to hydrops fetalis, nonimmune and hydrops fetalis. An important gene associated with Immune Hydrops Fetalis is GUSB (Glucuronidase Beta), and among its related pathways/superpathways are Lysosome and Binding and Uptake of Ligands by Scavenger Receptors. Affiliated tissues include bone, lung and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Immune Hydrops Fetalis

Diseases related to Immune Hydrops Fetalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 hydrops fetalis, nonimmune 33.3 GUSB HBA1 HBA2
2 hydrops fetalis 32.2 GBA GUSB HBA1 HBA2 PIEZO1
3 alpha-thalassemia 30.0 HBA1 HBA2
4 thalassemia 30.0 HBA1 HBA2
5 lysosomal storage disease 29.9 GBA GUSB
6 lymphatic malformation 7 11.8
7 mucopolysaccharidosis, type vii 11.7
8 lymphangiectasia, pulmonary, congenital 11.6
9 lymphatic malformation 6 11.6
10 arterial calcification of infancy 11.2
11 fetal edema 11.0
12 mucopolysaccharidosis-plus syndrome 10.3
13 teratoma 10.2
14 polyhydramnios 10.2
15 lymphangiectasis 10.2
16 polycythemia vera 10.1
17 legionnaires' disease 10.1
18 yellow nail syndrome 10.0
19 down syndrome 10.0
20 williams-beuren syndrome 10.0
21 neuraminidase deficiency 10.0
22 chylothorax, congenital 10.0
23 capillary malformation-arteriovenous malformation 1 10.0
24 congenital disorder of glycosylation, type in 10.0
25 lymphedema 10.0
26 osteopetrosis 10.0
27 diaphragmatic eventration 10.0
28 arteriovenous malformation 10.0
29 listeriosis 10.0
30 cholestasis 10.0
31 syphilis 10.0
32 bone marrow cancer 10.0
33 inherited metabolic disorder 10.0
34 herpes simplex 10.0
35 erythema infectiosum 10.0
36 zellweger syndrome 10.0
37 congenital syphilis 10.0
38 myotonic dystrophy 10.0
39 chromosomal triplication 10.0
40 myotonia atrophica 10.0
41 parvovirus antenatal infection 10.0
42 pulmonary sequestration 10.0
43 cytomegalovirus infection 10.0
44 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.0 HBA1 HBA2
45 methemoglobinemia, beta-globin type 10.0 HBA1 HBA2
46 diabetes mellitus, insulin-dependent, 24 10.0 HBA1 HBA2
47 glutathione peroxidase deficiency 10.0 HBA1 HBA2
48 hypoglycemic coma 10.0 HBA1 HBA2
49 heinz body anemias 10.0 HBA1 HBA2
50 splenomegaly 10.0 GBA HBA2

Graphical network of the top 20 diseases related to Immune Hydrops Fetalis:



Diseases related to Immune Hydrops Fetalis

Symptoms & Phenotypes for Immune Hydrops Fetalis

GenomeRNAi Phenotypes related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.23 HBA1 HBA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.23 HBA1 HBA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.23 HBA1 HBA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.23 HBA1 HBA2

Drugs & Therapeutics for Immune Hydrops Fetalis

Search Clinical Trials , NIH Clinical Center for Immune Hydrops Fetalis

Genetic Tests for Immune Hydrops Fetalis

Anatomical Context for Immune Hydrops Fetalis

MalaCards organs/tissues related to Immune Hydrops Fetalis:

42
Bone, Lung, Testes, Pituitary, Bone Marrow

Publications for Immune Hydrops Fetalis

Articles related to Immune Hydrops Fetalis:

(show top 50) (show all 115)
# Title Authors Year
1
Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. ( 30883972 )
2019
2
Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. ( 31028252 )
2019
3
A System-Based Approach to the Genetic Etiologies of Non-Immune Hydrops Fetalis. ( 31087399 )
2019
4
Recurrent Non-immune Fetal Hydrops Associated With IPEX Syndrome. ( 30813833 )
2019
5
Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. ( 28822227 )
2018
6
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2018
7
Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )
2018
8
Non-immune hydrops fetalis: A retrospective analysis of 151 autopsies performed at a single center. ( 30968631 )
2018
9
No. 363-Investigation and Management of Non-immune Fetal Hydrops. ( 30103882 )
2018
10
Congenital Disorder of Glycosylation (CDG) Presenting as Non-immune Hydrops Fetalis. ( 26365158 )
2016
11
Perinatal and one-year outcomes of non-immune hydrops fetalis by etiology and age at diagnosis. ( 26712114 )
2016
12
A Rare Association of Non-Compaction of the Ventricular Myocardium, and Non-Immune Hydrops Fetalis. ( 27328555 )
2016
13
Kabuki syndrome as a cause of non-immune fetal hydrops/ascites. ( 27568880 )
2016
14
Maternal and fetal capillary malformation-arteriovenous malformation (CM-AVM) due to a novel RASA1 mutation presenting with prenatal non-immune hydrops fetalis. ( 26096958 )
2015
15
Non-immune hydrops fetalis as a diagnostic and survival problems: what do we tell the parents? ( 25294712 )
2015
16
Etiology of non-immune hydrops fetalis: An update. ( 25712632 )
2015
17
Non-immune Hydrops fetalis due to Parvovirus B19 Infection in 2 Extremely Preterm Infants: Perinatal Management and Long-term Neurodevelopmental Outcome. ( 25830498 )
2015
18
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. ( 26333996 )
2015
19
Congenital generalized lymphangiectasia: a rare developmental disorder for non-immune fetal hydrops. ( 26894043 )
2015
20
Ballantyne Syndrome (Mirror Syndrome) associated with severe non-immune fetal hydrops--a case report. ( 26665574 )
2015
21
Non-immune hydrops fetalis without anemia due to parvovirus B19. ( 24140219 )
2014
22
Transient myeloproliferative disorder and non-immune hydrops fetalis in a neonate with trisomy 21. ( 24473698 )
2014
23
Accessory diaphragm associated with non-immune hydrops fetalis. ( 25100808 )
2014
24
Investigation and management of non-immune fetal hydrops. ( 24518907 )
2014
25
Cholestasis in infants with immune hydrops fetalis. ( 24577980 )
2013
26
Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection. ( 24071962 )
2013
27
Non-immune hydrops fetalis: A prospective study of 53 cases. ( 24039125 )
2013
28
Non-immune hydrops fetalis. ( 24283082 )
2013
29
Investigation and management of non-immune fetal hydrops. ( 24165062 )
2013
30
Are alanine, cysteine, glycine and valine amino acids the cause of non-immune hydrops fetalis? ( 23157039 )
2012
31
CCBE1 mutations can cause a mild, atypical form of generalized lymphatic dysplasia but are not a common cause of non-immune hydrops fetalis. ( 22239599 )
2012
32
Non-immune hydrops fetalis: a short review of etiology and pathophysiology. ( 22302731 )
2012
33
Intrauterine blood transfusion in immune hydrops fetalis, corrects middle cerebral artery Doppler velocimetry very quickly. ( 22364302 )
2012
34
Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents? ( 21268039 )
2011
35
Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. ( 21592689 )
2011
36
Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study. ( 21833460 )
2011
37
Was alpha-thalassemia searched as a cause of non-immune "hydrops fetalis?". ( 21428207 )
2010
38
Successful outcome with intrauterine transfusion in non-immune hydrops fetalis secondary to congenital syphilis. ( 21050519 )
2010
39
Immunohistochemistry in non-immune hydrops fetalis: a single center experience in 79 fetuses. ( 20425823 )
2010
40
Acute non-immune hydrops fetalis caused by intrauterine echovirus infection. ( 22791477 )
2010
41
Metastatic fetal neuroblastoma with non immune fetal hydrops. ( 20091466 )
2010
42
A diagnostic flow chart for non-immune hydrops fetalis. ( 19334092 )
2009
43
Zellweger syndrome with unusual findings: non-immune hydrops fetalis, dermal erythropoiesis and hypoplastic toe nails. ( 20033294 )
2009
44
Recurrent non-immune hydrops fetalis with gracile bones and dysmorphic features in siblings. ( 18478587 )
2008
45
Right-sided diaphragmatic eventration: a rare cause of non-immune hydrops fetalis. ( 17596732 )
2007
46
Fetal cerebellar hemorrhage in parvovirus-associated non-immune hydrops fetalis. ( 17763280 )
2007
47
Non-immune fetal hydrops: Are we doing the appropriate tests each time? ( 22470821 )
2007
48
Lysosomal storage diseases in non-immune hydrops fetalis pregnancies. ( 16674934 )
2006
49
Severity of non-immune hydrops fetalis at birth continues to predict survival despite advances in perinatal care. ( 16757915 )
2006
50
Recurrent non-immune fetal hydrops: A case report. ( 17102898 )
2006

Variations for Immune Hydrops Fetalis

Expression for Immune Hydrops Fetalis

Search GEO for disease gene expression data for Immune Hydrops Fetalis.

Pathways for Immune Hydrops Fetalis

GO Terms for Immune Hydrops Fetalis

Cellular components related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.67 GBA GUSB HBA1 HBA2
2 blood microparticle GO:0072562 9.4 HBA1 HBA2
3 lysosomal lumen GO:0043202 9.32 GBA GUSB
4 cytosolic small ribosomal subunit GO:0022627 9.26 HBA1 HBA2
5 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
6 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
7 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.4 HBA1 HBA2
2 protein heterooligomerization GO:0051291 9.37 HBA1 HBA2
3 response to hydrogen peroxide GO:0042542 9.32 HBA1 HBA2
4 positive regulation of cell death GO:0010942 9.26 HBA1 HBA2
5 bicarbonate transport GO:0015701 9.16 HBA1 HBA2
6 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
7 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 HBA1 HBA2
2 iron ion binding GO:0005506 9.4 HBA1 HBA2
3 hydrolase activity, acting on glycosyl bonds GO:0016798 9.37 GBA GUSB
4 oxygen binding GO:0019825 9.32 HBA1 HBA2
5 peroxidase activity GO:0004601 9.26 HBA1 HBA2
6 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
7 organic acid binding GO:0043177 8.96 HBA1 HBA2
8 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Immune Hydrops Fetalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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