IHF
MCID: IMM039
MIFTS: 30

Immune Hydrops Fetalis (IHF)

Categories: Fetal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Immune Hydrops Fetalis

MalaCards integrated aliases for Immune Hydrops Fetalis:

Name: Immune Hydrops Fetalis 60 74
Immune Fetal Hydrops 60
Immune Fetal Edema 60
Immune Hf 60
Ihf 60

Characteristics:

Orphanet epidemiological data:

60
immune hydrops fetalis
Inheritance: Not applicable; Prevalence: 1-5/10000 (United Kingdom); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



External Ids:

ICD10 via Orphanet 35 P56.0
UMLS via Orphanet 75 C0455990
Orphanet 60 ORPHA364013
UMLS 74 C0455990

Summaries for Immune Hydrops Fetalis

MalaCards based summary : Immune Hydrops Fetalis, also known as immune fetal hydrops, is related to hydrops fetalis, nonimmune and hydrops fetalis. An important gene associated with Immune Hydrops Fetalis is GUSB (Glucuronidase Beta), and among its related pathways/superpathways are Metabolism and Lysosome. Affiliated tissues include lung, bone and testes, and related phenotype is mortality/aging.

Related Diseases for Immune Hydrops Fetalis

Diseases related to Immune Hydrops Fetalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 hydrops fetalis, nonimmune 33.7 GUSB HBA2
2 hydrops fetalis 32.0 GBA GBE1 GUSB HBA2 PIEZO1
3 lymphatic malformation 7 11.8
4 mucopolysaccharidosis, type vii 11.6
5 lymphatic malformation 6 11.3
6 fetal edema 11.0
7 teratoma 10.2
8 polyhydramnios 10.2
9 polycythemia vera 10.1
10 legionnaires' disease 10.1
11 yellow nail syndrome 10.0
12 williams-beuren syndrome 10.0
13 neuraminidase deficiency 10.0
14 lymphangiectasia, pulmonary, congenital 10.0
15 chylothorax, congenital 10.0
16 capillary malformation-arteriovenous malformation 1 10.0
17 congenital disorder of glycosylation, type in 10.0
18 lymphedema 10.0
19 osteopetrosis 10.0
20 diaphragmatic eventration 10.0
21 arteriovenous malformation 10.0
22 listeriosis 10.0
23 cholestasis 10.0
24 syphilis 10.0
25 bone marrow cancer 10.0
26 inherited metabolic disorder 10.0
27 herpes simplex 10.0
28 erythema infectiosum 10.0
29 zellweger syndrome 10.0
30 congenital syphilis 10.0
31 myotonic dystrophy 10.0
32 myotonia atrophica 10.0
33 parvovirus antenatal infection 10.0
34 pulmonary sequestration 10.0
35 cytomegalovirus infection 10.0
36 splenomegaly 9.9 GBA HBA2
37 hemangioma-thrombocytopenia syndrome 9.9
38 kabuki syndrome 1 9.9
39 neuroblastoma 9.9
40 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9
41 tuberous sclerosis 9.9
42 cystic lymphangioma 9.9
43 hemangioendothelioma 9.9
44 lymphangiectasis 9.9
45 congenital hemolytic anemia 9.9 HBA2 PIEZO1
46 hemolytic anemia 9.8 HBA2 PIEZO1
47 lysosomal storage disease 9.7 GBA GUSB

Graphical network of the top 20 diseases related to Immune Hydrops Fetalis:



Diseases related to Immune Hydrops Fetalis

Symptoms & Phenotypes for Immune Hydrops Fetalis

MGI Mouse Phenotypes related to Immune Hydrops Fetalis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.1 GBA GBE1 GUSB HBA2 PIEZO1 UROS

Drugs & Therapeutics for Immune Hydrops Fetalis

Search Clinical Trials , NIH Clinical Center for Immune Hydrops Fetalis

Genetic Tests for Immune Hydrops Fetalis

Anatomical Context for Immune Hydrops Fetalis

MalaCards organs/tissues related to Immune Hydrops Fetalis:

42
Lung, Bone, Testes, Pituitary

Publications for Immune Hydrops Fetalis

Articles related to Immune Hydrops Fetalis:

(show top 50) (show all 109)
# Title Authors Year
1
Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. ( 30883972 )
2019
2
Recurrent Non-immune Fetal Hydrops Associated With IPEX Syndrome. ( 30813833 )
2019
3
Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )
2018
4
No. 363-Investigation and Management of Non-immune Fetal Hydrops. ( 30103882 )
2018
5
Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. ( 28822227 )
2017
6
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2017
7
Perinatal and one-year outcomes of non-immune hydrops fetalis by etiology and age at diagnosis. ( 26712114 )
2016
8
A Rare Association of Non-Compaction of the Ventricular Myocardium, and Non-Immune Hydrops Fetalis. ( 27328555 )
2016
9
Kabuki syndrome as a cause of non-immune fetal hydrops/ascites. ( 27568880 )
2016
10
Congenital Disorder of Glycosylation (CDG) Presenting as Non-immune Hydrops Fetalis. ( 26365158 )
2015
11
Maternal and fetal capillary malformation-arteriovenous malformation (CM-AVM) due to a novel RASA1 mutation presenting with prenatal non-immune hydrops fetalis. ( 26096958 )
2015
12
Etiology of non-immune hydrops fetalis: An update. ( 25712632 )
2015
13
Non-immune Hydrops fetalis due to Parvovirus B19 Infection in 2 Extremely Preterm Infants: Perinatal Management and Long-term Neurodevelopmental Outcome. ( 25830498 )
2015
14
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. ( 26333996 )
2015
15
Congenital generalized lymphangiectasia: a rare developmental disorder for non-immune fetal hydrops. ( 26894043 )
2015
16
Ballantyne Syndrome (Mirror Syndrome) associated with severe non-immune fetal hydrops--a case report. ( 26665574 )
2015
17
Non-immune hydrops fetalis without anemia due to parvovirus B19. ( 24140219 )
2014
18
Non-immune hydrops fetalis as a diagnostic and survival problems: what do we tell the parents? ( 25294712 )
2014
19
Accessory diaphragm associated with non-immune hydrops fetalis. ( 25100808 )
2014
20
Transient myeloproliferative disorder and non-immune hydrops fetalis in a neonate with trisomy 21. ( 24473698 )
2014
21
Investigation and management of non-immune fetal hydrops. ( 24518907 )
2014
22
Non-immune hydrops fetalis. ( 24283082 )
2013
23
Cholestasis in infants with immune hydrops fetalis. ( 24577980 )
2013
24
Non-immune hydrops fetalis: A prospective study of 53 cases. ( 24039125 )
2013
25
Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection. ( 24071962 )
2013
26
Intrauterine blood transfusion in immune hydrops fetalis, corrects middle cerebral artery Doppler velocimetry very quickly. ( 22364302 )
2012
27
CCBE1 mutations can cause a mild, atypical form of generalized lymphatic dysplasia but are not a common cause of non-immune hydrops fetalis. ( 22239599 )
2012
28
Are alanine, cysteine, glycine and valine amino acids the cause of non-immune hydrops fetalis? ( 23157039 )
2012
29
Non-immune hydrops fetalis: a short review of etiology and pathophysiology. ( 22302731 )
2012
30
Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. ( 21592689 )
2011
31
Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study. ( 21833460 )
2011
32
Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents? ( 21268039 )
2011
33
Immunohistochemistry in non-immune hydrops fetalis: a single center experience in 79 fetuses. ( 20425823 )
2010
34
Acute non-immune hydrops fetalis caused by intrauterine echovirus infection. ( 22791477 )
2010
35
Successful outcome with intrauterine transfusion in non-immune hydrops fetalis secondary to congenital syphilis. ( 21050519 )
2010
36
Metastatic fetal neuroblastoma with non immune fetal hydrops. ( 20091466 )
2010
37
Zellweger syndrome with unusual findings: non-immune hydrops fetalis, dermal erythropoiesis and hypoplastic toe nails. ( 20033294 )
2009
38
A diagnostic flow chart for non-immune hydrops fetalis. ( 19334092 )
2009
39
Recurrent non-immune hydrops fetalis with gracile bones and dysmorphic features in siblings. ( 18478587 )
2008
40
Fetal cerebellar hemorrhage in parvovirus-associated non-immune hydrops fetalis. ( 17763280 )
2007
41
Right-sided diaphragmatic eventration: a rare cause of non-immune hydrops fetalis. ( 17596732 )
2007
42
Non-immune fetal hydrops: Are we doing the appropriate tests each time? ( 22470821 )
2007
43
Lysosomal storage diseases in non-immune hydrops fetalis pregnancies. ( 16674934 )
2006
44
Severity of non-immune hydrops fetalis at birth continues to predict survival despite advances in perinatal care. ( 16757915 )
2006
45
Recurrent non-immune fetal hydrops: A case report. ( 17102898 )
2006
46
Non-immune hydrops fetalis: prenatal diagnosis and perinatal outcomes. ( 15895940 )
2005
47
Etiology and outcome of non-immune hydrops fetalis in southern Thailand. ( 15637431 )
2005
48
Autosomal recessive non-immune hydrops fetalis caused by systemic lymphangiectasia. ( 15690379 )
2005
49
Ventricular outflow obstruction, valve aplasia, bradyarrhythmia, pulmonary hypoplasia and non-immune fetal hydrops because of a large rhabdomyoma in a case of unknown tuberous sclerosis: a prenatal diagnosed cardiac rhabdomyoma with multiple symptoms. ( 15663143 )
2004
50
Pearson's syndrome: a rare cause of non-immune hydrops fetalis. ( 14986619 )
2003

Variations for Immune Hydrops Fetalis

Expression for Immune Hydrops Fetalis

Search GEO for disease gene expression data for Immune Hydrops Fetalis.

Pathways for Immune Hydrops Fetalis

Pathways related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 GBA GBE1 GUSB HBA2 UROS
2 10.71 GBA GUSB

GO Terms for Immune Hydrops Fetalis

Cellular components related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.26 GBA GBE1 GUSB HBA2
2 lysosomal lumen GO:0043202 8.62 GBA GUSB

Biological processes related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 8.62 GBA GUSB

Molecular functions related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 8.62 GBA GUSB

Sources for Immune Hydrops Fetalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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