IHF
MCID: IMM039
MIFTS: 30

Immune Hydrops Fetalis (IHF)

Categories: Fetal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Immune Hydrops Fetalis

MalaCards integrated aliases for Immune Hydrops Fetalis:

Name: Immune Hydrops Fetalis 58 71
Immune Fetal Hydrops 58
Immune Fetal Edema 58
Immune Hf 58
Ihf 58

Characteristics:

Orphanet epidemiological data:

58
immune hydrops fetalis
Inheritance: Not applicable; Prevalence: 1-5/10000 (United Kingdom); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 P56.0
UMLS via Orphanet 72 C0455990
Orphanet 58 ORPHA364013
UMLS 71 C0455990

Summaries for Immune Hydrops Fetalis

MalaCards based summary : Immune Hydrops Fetalis, also known as immune fetal hydrops, is related to hydrops fetalis, nonimmune and mucopolysaccharidosis-plus syndrome. An important gene associated with Immune Hydrops Fetalis is GUSB (Glucuronidase Beta), and among its related pathways/superpathways is Lysosome. Affiliated tissues include heart, lung and bone.

Related Diseases for Immune Hydrops Fetalis

Diseases related to Immune Hydrops Fetalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 hydrops fetalis, nonimmune 32.8 HBA1 GUSB GBA
2 mucopolysaccharidosis-plus syndrome 29.9 GUSB GBA
3 lysosomal storage disease 29.8 GUSB GBA
4 piezo1-related generalized lymphatic dysplasia with non-immune hydrops fetalis 12.6
5 mucopolysaccharidosis, type vii 11.8
6 lymphangiectasia, pulmonary, congenital 11.8
7 lymphatic malformation 6 11.8
8 ephb4-related lymphatic-related hydrops fetalis 11.6
9 lymphatic malformation 7 11.4
10 lymphatic malformation 8 11.4
11 arterial calcification of infancy 11.4
12 polyhydramnios 10.5
13 lymphangiectasis 10.4
14 inherited metabolic disorder 10.3
15 thalassemia 10.3
16 cystic lymphangioma 10.3
17 hemolytic anemia 10.3
18 congestive heart failure 10.3
19 papillomatosis, confluent and reticulated 10.3
20 myotonic dystrophy 1 10.2
21 down syndrome 10.2
22 galactosialidosis 10.2
23 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.2
24 alpha-thalassemia 10.2
25 deficiency anemia 10.2
26 teratoma 10.2
27 turner syndrome 10.2
28 syphilis 10.2
29 myocarditis 10.2
30 congenital syphilis 10.2
31 chromosomal triplication 10.2
32 cytomegalovirus infection 10.2
33 androgen insensitivity, partial 10.1
34 human immunodeficiency virus type 1 10.1
35 helix syndrome 10.1
36 middle east respiratory syndrome 10.1
37 chlamydia 10.1
38 hepatitis a 10.1
39 acute cystitis 10.1
40 disease of mental health 10.1
41 cystitis 10.1
42 haemophilus influenzae 10.1
43 rapidly involuting congenital hemangioma 10.1
44 diaphragmatic hernia, congenital 10.0
45 hypertelorism 10.0
46 yellow nail syndrome 10.0
47 lymphedema-distichiasis syndrome 10.0
48 williams-beuren syndrome 10.0
49 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 10.0
50 chondrodysplasia punctata syndrome 10.0

Graphical network of the top 20 diseases related to Immune Hydrops Fetalis:



Diseases related to Immune Hydrops Fetalis

Symptoms & Phenotypes for Immune Hydrops Fetalis

Drugs & Therapeutics for Immune Hydrops Fetalis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment Unknown status NCT02956564
2 Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal Hydrops Recruiting NCT03911531
3 Hydrops: Diagnosing & Redefining Outcomes With Precision Study Recruiting NCT03412760
4 Multicentric Prospective Study to Screen Inborn Errors of Metabolism in Non-immune Hydrops Fetalis by Massively Parallel Sequencing Not yet recruiting NCT04308603

Search NIH Clinical Center for Immune Hydrops Fetalis

Genetic Tests for Immune Hydrops Fetalis

Anatomical Context for Immune Hydrops Fetalis

MalaCards organs/tissues related to Immune Hydrops Fetalis:

40
Heart, Lung, Bone, Brain, Kidney, Placenta, Testes

Publications for Immune Hydrops Fetalis

Articles related to Immune Hydrops Fetalis:

(show top 50) (show all 243)
# Title Authors PMID Year
1
Clinical characteristics and neonatal outcomes of liveborn newborns with hydrops fetalis treated in a tertiary level neonatal intensive care unit. 61
32212385 2020
2
Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosis. 61
32187745 2020
3
Infantile onset Pompe disease presenting with non-immune hydrops fetalis. 61
31467850 2019
4
Congenital erythropoietic porphyria: Recent advances. 61
30685241 2019
5
Pathway to diagnosis and burden of illness in mucopolysaccharidosis type VII - a European caregiver survey. 61
31727109 2019
6
A system-based approach to the genetic etiologies of non-immune hydrops fetalis. 61
31087399 2019
7
Etiology and Outcome of non-immune Hydrops Fetalis in Southern China: report of 1004 cases. 61
31341179 2019
8
Diamond-Blackfan anemia RPL35A: a case report. 61
31208452 2019
9
Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. 61
31028252 2019
10
Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. 61
30883972 2019
11
A Neonatal Case With Perinatal Lethal Gaucher Disease Associated With Missense G234E and H413P Heterozygous Mutations. 61
31192173 2019
12
Non-immune Hydrops Fetalis and Hepatic Dysfunction in a Preterm Infant With Congenital Syphilis. 61
31921721 2019
13
Placental chorioangioma associated with polyhydramnios and hydrops fetalis. 61
30700468 2019
14
Early fetal hydropic changes are associated with moderate dilatation of the brain ventricular system: A clue to a possible link between cervical lymphatic engorgement and ventricular dilatation? 61
31119910 2019
15
A new case report of severe mucopolysaccharidosis type VII: diagnosis, treatment with haematopoietic cell transplantation and prenatal diagnosis in a second pregnancy. 61
30442200 2018
16
Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. 61
28822227 2018
17
A recessive truncating variant in thrombospondin-1 domain containing protein 1 gene THSD1 is the underlying cause of nonimmune hydrops fetalis, congenital cardiac defects, and haemangiomas in four patients from a consanguineous family. 61
30055085 2018
18
N° 363 - Évaluation et prise en charge de l'anasarque fÅ“toplacentaire non immune. 61
29980442 2018
19
No. 363-Investigation and Management of Non-immune Fetal Hydrops. 61
30103882 2018
20
Generalized arterial calcification of infancy with a novel ENPP1 mutation: a case report. 61
29976176 2018
21
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? 61
29076544 2018
22
Loss of function mutations in EPHB4 are responsible for vein of Galen aneurysmal malformation. 61
29444212 2018
23
Infection status of human parvovirus B19, cytomegalovirus and herpes simplex Virus-1/2 in women with first-trimester spontaneous abortions in Chongqing, China. 61
29688863 2018
24
A case of vasculopathy of unknown etiology associated with fatal hydrops fetalis and review of the literature on intimomedial mucoid degeneration. 61
29414431 2018
25
[Progress in genetic research on non-immune hydrops fetalis]. 61
29419878 2018
26
Thymic teratoma presenting as non-immune hydrops fetalis. 61
29515979 2018
27
Non-immune hydrops fetalis: A retrospective analysis of 151 autopsies performed at a single center. 61
30968631 2018
28
Coexistence of Kasabach-Merritt Syndrome and placental chorioangioma in a premature infant. 61
29991142 2018
29
Perinatal mortality in Japanese women diagnosed with gestational diabetes mellitus and diabetes mellitus. 61
28817202 2017
30
Development of a new tandem mass spectrometry method for urine and amniotic fluid screening of oligosaccharidoses. 61
28370531 2017
31
LC-MS/MS multiplex analysis of lysosphingolipids in plasma and amniotic fluid: A novel tool for the screening of sphingolipidoses and Niemann-Pick type C disease. 61
28749998 2017
32
Clinical course of sly syndrome (mucopolysaccharidosis type VII). 61
26908836 2016
33
Percutaneous umbilical blood sampling: current trends and outcomes. 61
27014852 2016
34
Congenital Disorder of Glycosylation (CDG) Presenting as Non-immune Hydrops Fetalis. 61
26365158 2016
35
Perinatal and one-year outcomes of non-immune hydrops fetalis by etiology and age at diagnosis. 61
26712114 2016
36
A Rare Association of Non-Compaction of the Ventricular Myocardium, and Non-Immune Hydrops Fetalis. 61
27328555 2016
37
[NEW APPROACH IN DIAGNOSTIC ALGORITHM OF AN INFECTIOUS AGENTS (PARVOVIRUS B19 AND CHLAMYDIA TRACHOMATIS) INVOLVED IN THE DEVELOPMENT OF PATHOLOGICAL PREGNANCY]. 61
27514136 2016
38
Maternal and fetal capillary malformation-arteriovenous malformation (CM-AVM) due to a novel RASA1 mutation presenting with prenatal non-immune hydrops fetalis. 61
26096958 2015
39
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. 61
26333996 2015
40
Non-immune Hydrops fetalis due to Parvovirus B19 Infection in 2 Extremely Preterm Infants: Perinatal Management and Long-term Neurodevelopmental Outcome. 61
25830498 2015
41
Etiology of non-immune hydrops fetalis: An update. 61
25712632 2015
42
Non-immune hydrops fetalis as a diagnostic and survival problems: what do we tell the parents? 61
25294712 2015
43
Primary endocardial fibroelastosis and nonimmune hydrops fetalis: case report with autopsy. 61
25517884 2015
44
Parvovirus B19 infection as a cause of acute myositis in an adult. 61
25839959 2015
45
De novo reciprocal translocation t(5;11)(q22;p15) associated with hydrops fetalis (reciprocal translocation and hydrops fetalis). 61
25289481 2015
46
Perinatal-lethal Gaucher disease presenting as hydrops fetalis. 61
26327947 2015
47
Relation between parvovirus B19 infection and fetal mortality and spontaneous abortion. 61
26157715 2015
48
Mediastinal teratoma with hydrops fetalis in a newborn and development of chronic respiratory insufficiency. 61
25435854 2014
49
Accessory diaphragm associated with non-immune hydrops fetalis. 61
25100808 2014
50
Etiology and outcome of hydrops fetalis: report of 62 cases. 61
24094760 2014

Variations for Immune Hydrops Fetalis

Expression for Immune Hydrops Fetalis

Search GEO for disease gene expression data for Immune Hydrops Fetalis.

Pathways for Immune Hydrops Fetalis

Pathways related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.73 GUSB GBA

GO Terms for Immune Hydrops Fetalis

Cellular components related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.26 HBA1 GUSB GBE1 GBA
2 lysosomal lumen GO:0043202 8.62 GUSB GBA

Biological processes related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 8.96 GUSB GBE1
2 metabolic process GO:0008152 8.62 GUSB GBA

Molecular functions related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.16 GBE1 GBA
2 hydrolase activity, acting on glycosyl bonds GO:0016798 8.96 GUSB GBA
3 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.62 GUSB GBE1

Sources for Immune Hydrops Fetalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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