IHF
MCID: IMM039
MIFTS: 36

Immune Hydrops Fetalis (IHF)

Categories: Fetal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Immune Hydrops Fetalis

MalaCards integrated aliases for Immune Hydrops Fetalis:

Name: Immune Hydrops Fetalis 59 73
Immune Fetal Hydrops 59
Immune Fetal Edema 59
Immune Hf 59
Ihf 59

Characteristics:

Orphanet epidemiological data:

59
immune hydrops fetalis
Inheritance: Not applicable; Prevalence: 1-5/10000 (United Kingdom); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



External Ids:

Orphanet 59 ORPHA364013
UMLS via Orphanet 74 C0455990
ICD10 via Orphanet 34 P56.0
UMLS 73 C0455990

Summaries for Immune Hydrops Fetalis

MalaCards based summary : Immune Hydrops Fetalis, also known as immune fetal hydrops, is related to hydrops fetalis, nonimmune and hydrops fetalis. An important gene associated with Immune Hydrops Fetalis is GUSB (Glucuronidase Beta), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria. Affiliated tissues include bone, lung and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Immune Hydrops Fetalis

Diseases related to Immune Hydrops Fetalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 hydrops fetalis, nonimmune 33.1 GUSB HBA1 HBA2
2 hydrops fetalis 32.3 GBE1 GUSB HBA1 HBA2 PIEZO1
3 hydrops fetalis, nonimmune, and/or atrial septal defect 11.8
4 mucopolysaccharidosis, type vii 11.6
5 lymphangiectasia, pulmonary, congenital 11.6
6 lymphedema, hereditary, iii 11.3
7 fetal edema 11.0
8 teratoma 10.2
9 polyhydramnios 10.2
10 polycythemia vera 10.1
11 williams-beuren syndrome 10.0
12 neuraminidase deficiency 10.0
13 chylothorax, congenital 10.0
14 capillary malformation-arteriovenous malformation 10.0
15 congenital disorder of glycosylation, type in 10.0
16 lymphedema 10.0
17 osteopetrosis 10.0
18 diaphragmatic eventration 10.0
19 arteriovenous malformation 10.0
20 listeriosis 10.0
21 cholestasis 10.0
22 syphilis 10.0
23 inherited metabolic disorder 10.0
24 herpes simplex 10.0
25 erythema infectiosum 10.0
26 zellweger syndrome 10.0
27 congenital syphilis 10.0
28 myotonic dystrophy 10.0
29 myotonia atrophica 10.0
30 parvovirus antenatal infection 10.0
31 pulmonary sequestration 10.0
32 cytomegalovirus infection 10.0
33 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 9.9 HBA1 HBA2
34 alpha-thalassemia 9.9 HBA1 HBA2
35 hemangioma-thrombocytopenia syndrome 9.9
36 kabuki syndrome 1 9.9
37 neuroblastoma 9.9
38 tuberous sclerosis 9.9
39 cystic lymphangioma 9.9
40 hemangioendothelioma 9.9
41 lymphangiectasis 9.9
42 thalassemia 9.9 HBA1 HBA2
43 methemoglobinemia, beta-globin type 9.9 HBA1 HBA2
44 diabetes mellitus, insulin-dependent, 24 9.9 HBA1 HBA2
45 glutathione peroxidase deficiency 9.9 HBA1 HBA2
46 hypoglycemic coma 9.9 HBA1 HBA2
47 heinz body anemias 9.9 HBA1 HBA2
48 erythrocytosis, familial, 7 9.9 HBA1 HBA2
49 type 1 diabetes mellitus 7 9.9 HBA1 HBA2
50 type 1 diabetes mellitus 11 9.8 HBA1 HBA2

Graphical network of the top 20 diseases related to Immune Hydrops Fetalis:



Diseases related to Immune Hydrops Fetalis

Symptoms & Phenotypes for Immune Hydrops Fetalis

GenomeRNAi Phenotypes related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 HBA1 HBA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 HBA1 HBA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 HBA1 HBA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.53 HBA1 HBA2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.43 HBA1 HBA2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.43 HBA1 HBA2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.43 HBA1 HBA2

Drugs & Therapeutics for Immune Hydrops Fetalis

Search Clinical Trials , NIH Clinical Center for Immune Hydrops Fetalis

Genetic Tests for Immune Hydrops Fetalis

Anatomical Context for Immune Hydrops Fetalis

MalaCards organs/tissues related to Immune Hydrops Fetalis:

41
Bone, Lung, Pituitary, Skin, Brain, Bone Marrow, Testes

Publications for Immune Hydrops Fetalis

Articles related to Immune Hydrops Fetalis:

(show top 50) (show all 107)
# Title Authors Year
1
Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )
2018
2
No. 363-Investigation and Management of Non-immune Fetal Hydrops. ( 30103882 )
2018
3
Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. ( 28822227 )
2017
4
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2017
5
Perinatal and one-year outcomes of non-immune hydrops fetalis by etiology and age at diagnosis. ( 26712114 )
2016
6
A Rare Association of Non-Compaction of the Ventricular Myocardium, and Non-Immune Hydrops Fetalis. ( 27328555 )
2016
7
Kabuki syndrome as a cause of non-immune fetal hydrops/ascites. ( 27568880 )
2016
8
Congenital Disorder of Glycosylation (CDG) Presenting as Non-immune Hydrops Fetalis. ( 26365158 )
2015
9
Maternal and fetal capillary malformation-arteriovenous malformation (CM-AVM) due to a novel RASA1 mutation presenting with prenatal non-immune hydrops fetalis. ( 26096958 )
2015
10
Etiology of non-immune hydrops fetalis: An update. ( 25712632 )
2015
11
Non-immune Hydrops fetalis due to Parvovirus B19 Infection in 2 Extremely Preterm Infants: Perinatal Management and Long-term Neurodevelopmental Outcome. ( 25830498 )
2015
12
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. ( 26333996 )
2015
13
Congenital generalized lymphangiectasia: a rare developmental disorder for non-immune fetal hydrops. ( 26894043 )
2015
14
Ballantyne Syndrome (Mirror Syndrome) associated with severe non-immune fetal hydrops--a case report. ( 26665574 )
2015
15
Non-immune hydrops fetalis without anemia due to parvovirus B19. ( 24140219 )
2014
16
Non-immune hydrops fetalis as a diagnostic and survival problems: what do we tell the parents? ( 25294712 )
2014
17
Accessory diaphragm associated with non-immune hydrops fetalis. ( 25100808 )
2014
18
Transient myeloproliferative disorder and non-immune hydrops fetalis in a neonate with trisomy 21. ( 24473698 )
2014
19
Investigation and management of non-immune fetal hydrops. ( 24518907 )
2014
20
Non-immune hydrops fetalis. ( 24283082 )
2013
21
Cholestasis in infants with immune hydrops fetalis. ( 24577980 )
2013
22
Non-immune hydrops fetalis: A prospective study of 53 cases. ( 24039125 )
2013
23
Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection. ( 24071962 )
2013
24
Intrauterine blood transfusion in immune hydrops fetalis, corrects middle cerebral artery Doppler velocimetry very quickly. ( 22364302 )
2012
25
CCBE1 mutations can cause a mild, atypical form of generalized lymphatic dysplasia but are not a common cause of non-immune hydrops fetalis. ( 22239599 )
2012
26
Are alanine, cysteine, glycine and valine amino acids the cause of non-immune hydrops fetalis? ( 23157039 )
2012
27
Non-immune hydrops fetalis: a short review of etiology and pathophysiology. ( 22302731 )
2012
28
Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. ( 21592689 )
2011
29
Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study. ( 21833460 )
2011
30
Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents? ( 21268039 )
2011
31
Immunohistochemistry in non-immune hydrops fetalis: a single center experience in 79 fetuses. ( 20425823 )
2010
32
Acute non-immune hydrops fetalis caused by intrauterine echovirus infection. ( 22791477 )
2010
33
Successful outcome with intrauterine transfusion in non-immune hydrops fetalis secondary to congenital syphilis. ( 21050519 )
2010
34
Metastatic fetal neuroblastoma with non immune fetal hydrops. ( 20091466 )
2010
35
Zellweger syndrome with unusual findings: non-immune hydrops fetalis, dermal erythropoiesis and hypoplastic toe nails. ( 20033294 )
2009
36
A diagnostic flow chart for non-immune hydrops fetalis. ( 19334092 )
2009
37
Recurrent non-immune hydrops fetalis with gracile bones and dysmorphic features in siblings. ( 18478587 )
2008
38
Fetal cerebellar hemorrhage in parvovirus-associated non-immune hydrops fetalis. ( 17763280 )
2007
39
Right-sided diaphragmatic eventration: a rare cause of non-immune hydrops fetalis. ( 17596732 )
2007
40
Non-immune fetal hydrops: Are we doing the appropriate tests each time? ( 22470821 )
2007
41
Lysosomal storage diseases in non-immune hydrops fetalis pregnancies. ( 16674934 )
2006
42
Severity of non-immune hydrops fetalis at birth continues to predict survival despite advances in perinatal care. ( 16757915 )
2006
43
Recurrent non-immune fetal hydrops: A case report. ( 17102898 )
2006
44
Non-immune hydrops fetalis: prenatal diagnosis and perinatal outcomes. ( 15895940 )
2005
45
Etiology and outcome of non-immune hydrops fetalis in southern Thailand. ( 15637431 )
2005
46
Autosomal recessive non-immune hydrops fetalis caused by systemic lymphangiectasia. ( 15690379 )
2005
47
Ventricular outflow obstruction, valve aplasia, bradyarrhythmia, pulmonary hypoplasia and non-immune fetal hydrops because of a large rhabdomyoma in a case of unknown tuberous sclerosis: a prenatal diagnosed cardiac rhabdomyoma with multiple symptoms. ( 15663143 )
2004
48
Pearson's syndrome: a rare cause of non-immune hydrops fetalis. ( 14986619 )
2003
49
A new case of mucopolysaccharidosis VII presenting as non immune hydrops fetalis. ( 12748853 )
2003
50
Mucopolysaccharidosis type VII as a cause of recurrent non-immune hydrops fetalis. ( 14711113 )
2003

Variations for Immune Hydrops Fetalis

Expression for Immune Hydrops Fetalis

Search GEO for disease gene expression data for Immune Hydrops Fetalis.

Pathways for Immune Hydrops Fetalis

GO Terms for Immune Hydrops Fetalis

Cellular components related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.62 GBE1 GUSB HBA1 HBA2
2 blood microparticle GO:0072562 9.37 HBA1 HBA2
3 cytosolic small ribosomal subunit GO:0022627 9.26 HBA1 HBA2
4 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
5 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
6 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.4 HBA1 HBA2
2 protein heterooligomerization GO:0051291 9.37 HBA1 HBA2
3 response to hydrogen peroxide GO:0042542 9.32 HBA1 HBA2
4 positive regulation of cell death GO:0010942 9.26 HBA1 HBA2
5 bicarbonate transport GO:0015701 9.16 HBA1 HBA2
6 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
7 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Immune Hydrops Fetalis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.4 HBA1 HBA2
2 iron ion binding GO:0005506 9.37 HBA1 HBA2
3 oxygen binding GO:0019825 9.32 HBA1 HBA2
4 peroxidase activity GO:0004601 9.26 HBA1 HBA2
5 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
6 organic acid binding GO:0043177 8.96 HBA1 HBA2
7 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Immune Hydrops Fetalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....