MCID: IMM136
MIFTS: 49

Immune System Disease

Categories: Immune diseases

Aliases & Classifications for Immune System Disease

MalaCards integrated aliases for Immune System Disease:

Name: Immune System Disease 12 15
Abnormality of the Immune System 29
Immune System and Disorders 43
Immune System Diseases 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2914
ICD10 33 D89.9
ICD9CM 35 279 279.9

Summaries for Immune System Disease

MedlinePlus : 43 Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them. If your immune system cannot do its job, the results can be serious. Disorders of the immune system include Allergy and asthma - immune responses to substances that are usually not harmful Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Immune System Disease, also known as abnormality of the immune system, is related to immune deficiency disease and lymphatic system disease, and has symptoms including pathological conditions, signs and symptoms An important gene associated with Immune System Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Midazolam and Morphine have been mentioned in the context of this disorder. Affiliated tissues include t cells, kidney and colon, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A disease of anatomical entity that is located in the immune system.

Related Diseases for Immune System Disease

Diseases related to Immune System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 immune deficiency disease 32.8 IL10 IL2 IL4 TLR9
2 lymphatic system disease 31.9 IL2 TLR9 TNF
3 allergic hypersensitivity disease 31.8 IFNG IL10 IL4 TLR9
4 herpes zoster 31.7 IFNG IL10 IL2 TRPV1
5 temporal arteritis 31.7 APOH IFNG IL6 TNF
6 peripheral nervous system disease 31.6 AQP4 IL6 MBP MOG TLR9 TNF
7 autoimmune disease 31.3 APOH FOXP3 IFNG IL10 IL17A IL2
8 complement component 3 deficiency, autosomal recessive 11.3
9 trichohepatoenteric syndrome 1 10.9
10 autoinflammation, panniculitis, and dermatosis syndrome 10.8
11 autoimmune peripheral neuropathy 10.8
12 mononeuropathy 10.8
13 mononeuritis multiplex 10.8
14 sensory peripheral neuropathy 10.8
15 vasculitis syndromes of the central and peripheral nervous systems 10.8
16 retroperitoneal neuroblastoma 10.5 IFNB1 IL2
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
18 palladium allergic contact dermatitis 10.5 IL10 IL17A
19 microscopic polyangiitis 10.4 IL10 TNF
20 multifocal choroiditis 10.4 IL10 TNF
21 oral tuberculosis 10.4 IL2 TNF
22 punctate inner choroidopathy 10.4 IL10 TNF
23 allergic encephalomyelitis 10.4 MBP MOG
24 cephalosporin allergy 10.4 IFNG IL10
25 leukomalacia 10.4 IL6 TNF
26 virus associated hemophagocytic syndrome 10.4 IL2 IL4
27 scorpion envenomation 10.4 IL6 TNF
28 variola major 10.4 IFNG IL2
29 subacute cutaneous lupus erythematosus 10.4 TNF TRIM21
30 sudden sensorineural hearing loss 10.4 APOH IL6
31 subacute lymphocytic thyroiditis 10.4 IL2 TG
32 staphylococcal toxic shock syndrome 10.4 IFNG TNF
33 acute necrotizing encephalitis 10.4 FOXP3 IFNG
34 filarial elephantiasis 10.4 IL10 IL4 TLR9
35 autoimmune disease of peripheral nervous system 10.4 MBP MOG TNF
36 fixed drug eruption 10.4 IFNG IL2
37 hidradenitis suppurativa 10.4 IL17A NCSTN TNF
38 hidradenitis 10.4 IL17A NCSTN TNF
39 mucocutaneous leishmaniasis 10.4 IL10 TLR9 TNF
40 pulpitis 10.4 IL6 TNF TRPV1
41 genital herpes 10.4 IL10 IL4 TLR9
42 meningoencephalitis 10.4 IL6 MBP TLR9
43 apple allergy 10.4 FOXP3 IL10 IL4
44 gaucher disease, type ii 10.4 IL10 IL2 IL4
45 hypersensitivity reaction type iii disease 10.4 IL6 TLR9 TNF
46 kawasaki disease 10.4 IL10 IL6 TNF
47 adult respiratory distress syndrome 10.4 IL10 IL6 TNF
48 alcoholic hepatitis 10.4 IL10 IL6 TNF
49 post-transplant lymphoproliferative disease 10.4 IL10 IL6 TNF
50 cystitis 10.4 IL6 TNF TRPV1

Graphical network of the top 20 diseases related to Immune System Disease:



Diseases related to Immune System Disease

Symptoms & Phenotypes for Immune System Disease

UMLS symptoms related to Immune System Disease:


pathological conditions, signs and symptoms

MGI Mouse Phenotypes related to Immune System Disease:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.47 AQP4 FOXP3 IFNB1 IFNG IL10 IL17A
2 immune system MP:0005387 10.46 AQP4 FOXP3 IFNB1 IFNG IL10 IL17A
3 growth/size/body region MP:0005378 10.45 AQP4 FOXP3 IFNG IL10 IL17A IL2
4 homeostasis/metabolism MP:0005376 10.45 APOH AQP4 FOXP3 IFNB1 IFNG IL10
5 cellular MP:0005384 10.43 FOXP3 IFNG IL10 IL2 IL4 IL6
6 behavior/neurological MP:0005386 10.38 AQP4 FOXP3 IFNG IL10 IL2 IL6
7 mortality/aging MP:0010768 10.36 APOH AQP4 FOXP3 IFNG IL10 IL17A
8 digestive/alimentary MP:0005381 10.35 AQP4 FOXP3 IFNG IL10 IL17A IL2
9 cardiovascular system MP:0005385 10.33 AQP4 FOXP3 IFNG IL10 IL2 IL6
10 endocrine/exocrine gland MP:0005379 10.3 AQP4 FOXP3 IFNG IL10 IL17A IL2
11 nervous system MP:0003631 10.22 AQP4 IFNB1 IFNG IL10 IL4 IL6
12 integument MP:0010771 10.19 FOXP3 IFNG IL10 IL4 IL6 NCSTN
13 craniofacial MP:0005382 10.18 FOXP3 IFNG IL10 IL17A IL4 NCSTN
14 liver/biliary system MP:0005370 10.08 FOXP3 IFNG IL10 IL2 IL4 IL6
15 no phenotypic analysis MP:0003012 10.07 AQP4 FOXP3 IFNB1 IFNG IL10 IL17A
16 renal/urinary system MP:0005367 10.06 AQP4 FOXP3 IFNG IL17A IL4 IL6
17 neoplasm MP:0002006 10.03 IFNB1 IFNG IL10 IL2 IL6 NCSTN
18 reproductive system MP:0005389 9.91 FOXP3 IFNG IL10 IL2 IL4 IL6
19 respiratory system MP:0005388 9.81 AQP4 FOXP3 IFNG IL10 IL17A IL2
20 skeleton MP:0005390 9.65 IFNB1 IFNG IL10 IL17A IL4 IL6
21 vision/eye MP:0005391 9.36 AQP4 FOXP3 IFNG IL10 IL2 IL4

Drugs & Therapeutics for Immune System Disease

Drugs for Immune System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1380)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1 59467-70-8 4192
2
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
3 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
5
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
6
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
7
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
8
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
9
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 155213-67-5 392622
10 sodium fluoride Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7681-49-4
11
Glycerol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 56-81-5 753
12
Fludrocortisone Approved, Investigational Phase 4 127-31-1 31378
13
Simvastatin Approved Phase 4,Phase 2,Phase 1,Not Applicable 79902-63-9 54454
14
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 111025-46-8 4829
15
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 7782-49-2
16
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 242138-07-4
17
Linagliptin Approved Phase 4,Not Applicable 668270-12-0 10096344
18
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
19
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
21
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
22
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
23
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
24
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
25
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6
26
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
27
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 116094-23-6 16132418
28
Enalapril Approved, Vet_approved Phase 4,Phase 2,Not Applicable 75847-73-3 5362032 40466924
29
Enalaprilat Approved Phase 4,Phase 2,Not Applicable 76420-72-9 6917719
30
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
31
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
32
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53608-75-6
33
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
34
Losartan Approved Phase 4,Phase 3,Phase 2,Not Applicable 114798-26-4 3961
35
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-45-6, 75614-87-8 774
36
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
37
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 10909430 439542
38
Bronopol Approved Phase 4 52-51-7
39 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
40
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-03-3
41
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-23-7 5754
42
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
43
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
44
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
45
Pheniramine Approved Phase 4,Phase 3 86-21-5 4761
46
Naphazoline Approved, Investigational Phase 4,Phase 3 835-31-4 4436
47
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
48
Glyburide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10238-21-8 3488
49
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
50
Levocetirizine Approved Phase 4,Phase 3,Phase 1,Phase 2 130018-77-8 1549000

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
2 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
3 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
4 TRPV Expression in Subjects With Sensitive Skin Unknown status NCT01871883 Phase 4
5 Safety of Ertapenem in Beta-lactam Allergic Patients. Unknown status NCT01159379 Phase 4 ertapenem
6 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
7 Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity Unknown status NCT02936830 Phase 4 5% Sodium Fluoride Varnish;15% Nanohydroxyapetite paste;Glycerol
8 Growth, Safety and Tolerance of a Rice Protein Hydrolysate Formula in Infants With Cow's Milk Protein Allergy Unknown status NCT02405923 Phase 4
9 Acthar for the Treatment of Systemic Lupus Erythematosus in Patients With a History of Persistently Active Disease Unknown status NCT01753401 Phase 4 Acthar;Placebo for Acthar
10 Fludrocortisone's Test in Salt Sensitivity Unknown status NCT01453959 Phase 4 Fludrocortisone
11 Can we Help People With the Oral Allergy Syndrome Eat Fresh Fruit? Unknown status NCT01431859 Phase 4
12 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
13 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
14 Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity Unknown status NCT01736202 Phase 4
15 Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD Unknown status NCT01253928 Phase 4 Pioglitazone
16 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
17 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
18 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
19 Effect of Xolair on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4 Omalizumab;Placebo for Omalizumab;omalizumab
20 Diagnostic Immunization With Rabies Vaccine in Patients With PID Unknown status NCT02490956 Phase 4
21 Probiotics in Newly Recognized Type 1 Diabetes Unknown status NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
22 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
23 Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy Unknown status NCT02981212 Phase 4 Mycophenolate Mofetil;ACE inhibitor;Corticosteroid;ARB
24 Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps. Unknown status NCT02685449 Phase 4 Insulin glulisine;Insulin aspart;Insulin lispro
25 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
26 The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes Unknown status NCT02307695 Phase 4 Saxagliptin;Insulin
27 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
28 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
29 Ocular Allergy Treatment Practical Impact Trial Unknown status NCT01808768 Phase 4 Alcaftadine
30 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
31 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
32 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
33 Comparison of Tolerability Between Two Allergy Drops Unknown status NCT01390961 Phase 4 alacaftadine and naphazoline HCl & pheniramine maleate
34 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer Unknown status NCT01346371 Phase 4 Bepreve (bepotastine ophthalmic solution) 1.5%
35 Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses Unknown status NCT01337557 Phase 4 Bepotastine
36 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
37 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
38 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
39 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
40 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
41 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
42 The Efficacy and Safety of Desloratadine With Levocetirizine in Treatment of Chronic Idiopathic Urticaria Unknown status NCT00346606 Phase 4 Denosin® and Xyzal®
43 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
44 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
45 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
46 An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes Unknown status NCT02962492 Phase 4 Exenatide/Exenatide extended release;Dapagliflozin;Placebo
47 PEG-rhG-CSF in Lymphoma Patients After Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT02905942 Phase 4 PEG-rhG-CSF;rhG-CSF
48 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
49 The Clinical Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months Treatment Unknown status NCT02837978 Phase 4 Tacrolimus;MTX
50 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate

Search NIH Clinical Center for Immune System Disease

Genetic Tests for Immune System Disease

Genetic tests related to Immune System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Immune System 29

Anatomical Context for Immune System Disease

MalaCards organs/tissues related to Immune System Disease:

41
T Cells, Kidney, Colon, Heart, Thyroid, B Cells, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Immune System Disease:

19
The Immune System

Publications for Immune System Disease

Variations for Immune System Disease

Expression for Immune System Disease

Search GEO for disease gene expression data for Immune System Disease.

Pathways for Immune System Disease

Pathways related to Immune System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 IFNB1 IFNG IL10 IL17A IL2 IL4
2
Show member pathways
13.56 IFNB1 IFNG IL10 IL17A IL2 IL4
3
Show member pathways
13.41 IFNB1 IFNG IL10 IL17A IL2 IL4
4
Show member pathways
13.07 IFNB1 IFNG IL10 IL2 IL6 TLR9
5
Show member pathways
12.93 FOXP3 IFNG IL10 IL17A IL2 IL4
6
Show member pathways
12.85 IFNB1 IFNG IL2 IL4 IL6 TLR9
7
Show member pathways
12.66 IFNG IL10 IL2 IL4 TNF
8
Show member pathways
12.65 IFNG IL10 IL17A IL2 IL6 TNF
9
Show member pathways
12.63 FOXP3 IFNG IL10 IL17A IL2 IL4
10 12.57 FOXP3 IFNG IL10 IL17A IL2 IL4
11
Show member pathways
12.56 IFNB1 IFNG IL2 IL4 TNF
12
Show member pathways
12.51 IFNG IL10 IL17A IL2 IL4 IL6
13
Show member pathways
12.48 IFNB1 IFNG IL10 IL2 IL4 IL6
14
Show member pathways
12.4 IFNG IL2 IL4 IL6 TNF
15
Show member pathways
12.39 IFNG IL17A IL4 IL6 TNF
16 12.31 IFNB1 IFNG IL10 IL6 TLR9 TNF
17
Show member pathways
12.29 IFNB1 IL6 TLR9 TNF
18
Show member pathways
12.29 IL10 IL2 IL6 TLR9 TNF
19
Show member pathways
12.29 IFNB1 IFNG IL10 IL17A IL2 IL4
20
Show member pathways
12.28 IFNG IL10 IL4 TNF
21
Show member pathways
12.26 IFNB1 IFNG IL4 IL6 TLR9 TNF
22 12.22 IFNG IL6 TLR9 TNF
23 12.21 AQP4 IL10 IL6 TNF
24
Show member pathways
12.14 IFNG IL10 IL17A IL2 IL4 IL6
25
Show member pathways
12.08 IFNG IL4 IL6 TNF
26 12.07 IFNG IL10 IL2 IL4 IL6 TNF
27 12.06 IL10 IL17A IL4 IL6 TNF
28
Show member pathways
11.98 IFNG IL10 IL17A IL2 IL6 TLR9
29 11.96 IFNG IL10 IL6 TNF
30 11.95 IFNB1 IFNG IL10 IL2 IL6
31 11.93 IFNG IL17A IL6 TNF
32 11.88 AQP4 IFNG IL2 IL4 IL6 MBP
33
Show member pathways
11.87 FOXP3 IL17A IL6
34 11.87 IFNG IL2 IL4 IL6
35
Show member pathways
11.85 FOXP3 IFNG IL2 IL4 TNF
36 11.78 IL10 IL6 TNF
37 11.75 IFNG IL10 IL17A IL2 IL4 TNF
38
Show member pathways
11.74 IFNG IL2 IL6 TNF
39
Show member pathways
11.72 FOXP3 IL2 IL4
40 11.69 IL4 IL6 TNF
41
Show member pathways
11.68 IFNG IL2 TNF
42 11.64 IFNG IL2 IL6 TNF
43 11.64 IFNG IL10 IL6 TLR9 TNF
44 11.62 IL6 TNF VCP
45 11.61 IL10 IL4 IL6 TNF
46 11.57 FOXP3 IFNG IL10 IL2 IL4
47 11.57 IFNB1 IFNG IL10 IL2 IL6 TLR9
48 11.56 IFNG IL2 TNF
49 11.52 IFNG IL6 TNF
50 11.41 IL10 IL6 TNF

GO Terms for Immune System Disease

Cellular components related to Immune System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 APOH IFNB1 IFNG IL10 IL17A IL2
2 external side of plasma membrane GO:0009897 9.55 AQP4 IL17A MOG TNF TRPV1
3 extracellular region GO:0005576 9.4 APOH IFNB1 IFNG IL10 IL17A IL2

Biological processes related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 FOXP3 IFNG IL4 IL6 TLR9 TNF
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 FOXP3 IFNB1 IL10 IL17A IL2 IL4
3 defense response to virus GO:0051607 9.94 IFNB1 IFNG IL6 TLR9
4 inflammatory response GO:0006954 9.93 IL10 IL17A IL6 TLR9 TNF TRPV1
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.87 IL10 IL6 TNF TRIM21
6 positive regulation of inflammatory response GO:0050729 9.86 IL2 TLR9 TNF
7 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.86 FOXP3 TLR9 TRIM21
8 response to virus GO:0009615 9.86 FOXP3 IFNB1 IFNG TNF
9 B cell differentiation GO:0030183 9.85 IFNB1 IL10 IL4
10 response to glucocorticoid GO:0051384 9.84 IL10 IL6 TNF
11 positive regulation of T cell proliferation GO:0042102 9.83 IL2 IL4 IL6
12 positive regulation of interleukin-6 production GO:0032755 9.83 IL6 TLR9 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 IFNG TNF TRPV1
14 positive regulation of B cell proliferation GO:0030890 9.77 IL2 IL4 TLR9
15 regulation of synapse organization GO:0050807 9.72 IL10 TNF VCP
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 IFNG IL2 IL4 IL6
17 negative regulation of interleukin-17 production GO:0032700 9.7 FOXP3 IFNG
18 positive regulation of immunoglobulin secretion GO:0051024 9.7 IL2 IL6
19 positive regulation of regulatory T cell differentiation GO:0045591 9.7 FOXP3 IL2
20 positive regulation of protein complex assembly GO:0031334 9.7 IFNG TNF VCP
21 cytokine-mediated signaling pathway GO:0019221 9.7 IFNB1 IL10 IL17A IL2 IL4 IL6
22 response to molecule of bacterial origin GO:0002237 9.69 IL10 TLR9
23 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.69 IL10 MBP
24 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR9 TNF
25 positive regulation of isotype switching to IgG isotypes GO:0048304 9.68 IL2 IL4
26 myeloid cell homeostasis GO:0002262 9.67 FOXP3 NCSTN
27 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
28 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG IL17A TNF
29 humoral immune response GO:0006959 9.67 IFNB1 IFNG IL6 TNF
30 endothelial cell apoptotic process GO:0072577 9.66 IL10 TNF
31 negative regulation of T-helper 17 cell differentiation GO:2000320 9.66 FOXP3 IL2
32 negative regulation of interleukin-8 production GO:0032717 9.65 IL10 TLR9
33 positive regulation of chemokine production GO:0032722 9.65 IL6 TLR9 TNF
34 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IL4
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
36 negative regulation of lymphocyte proliferation GO:0050672 9.63 FOXP3 IL2
37 positive regulation of neuroinflammatory response GO:0150078 9.62 IL6 TNF
38 positive regulation of interleukin-23 production GO:0032747 9.62 IFNG IL17A
39 regulation of isotype switching GO:0045191 9.61 IL10 IL4
40 regulation of regulatory T cell differentiation GO:0045589 9.61 FOXP3 IFNG IL2
41 immune response GO:0006955 9.61 IFNG IL10 IL17A IL2 IL4 IL6
42 type 2 immune response GO:0042092 9.6 IL10 IL4
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG TNF
44 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
45 negative regulation of interleukin-6 production GO:0032715 9.56 FOXP3 IL10 TLR9 TNF
46 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
47 regulation of signaling receptor activity GO:0010469 9.28 IFNB1 IFNG IL10 IL17A IL2 IL4

Molecular functions related to Immune System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.23 IFNB1 IFNG IL10 IL17A IL2 IL4

Sources for Immune System Disease

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