Aliases & Classifications for Immune System Disease

MalaCards integrated aliases for Immune System Disease:

Name: Immune System Disease 12 15
Abnormality of the Immune System 29
Immune System and Disorders 43
Immune System Diseases 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2914
ICD10 33 D89.9
ICD9CM 35 279 279.9

Summaries for Immune System Disease

MedlinePlus : 43 Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them. If your immune system cannot do its job, the results can be serious. Disorders of the immune system include Allergy and asthma - immune responses to substances that are usually not harmful Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Immune System Disease, also known as abnormality of the immune system, is related to immune deficiency disease and temporal arteritis, and has symptoms including pathological conditions, signs and symptoms An important gene associated with Immune System Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Midazolam and Morphine have been mentioned in the context of this disorder. Affiliated tissues include the immune system, b cells and t cells, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Disease Ontology : 12 A disease of anatomical entity that is located in the immune system.

Related Diseases for Immune System Disease

Diseases related to Immune System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 418)
# Related Disease Score Top Affiliating Genes
1 immune deficiency disease 34.0 CD40LG CD79A IL2 IL4 TNF
2 temporal arteritis 32.8 APOH CD40LG IL6
3 allergic hypersensitivity disease 32.8 CD79A IL4 IL5 TLR9 TRPV1
4 autoimmune disease 32.2 APOH CD40LG CD79A IL2 IL4 IL5
5 hypersensitivity reaction disease 31.9 ALB APOH CD40LG CD79A IL2 IL4
6 selective igg deficiency disease 11.4 CD40LG CD79A
7 ocular toxoplasmosis 11.4 CD40LG CD79A TLR9
8 c1q nephropathy 11.4 CD40LG CD79A
9 cerebral arteritis 11.4 CD40LG CD79A VWF
10 cork-handlers' disease 11.4 ALB CD40LG CD79A
11 monoclonal paraproteinemia 11.4 CD40LG CD79A VWF
12 heparin-induced thrombocytopenia 11.4 CD40LG F3 SERPINC1
13 livedoid vasculopathy 11.4 APOH CD40LG F2
14 immunoglobulin a deficiency 1 11.4 CD40LG CD79A IL4
15 intestinal impaction 11.4 F2 F3 SERPINC1
16 spinal cord infarction 11.4 APOH F2 SERPINC1
17 qualitative platelet defect 11.4 F2 F3 VWF
18 leech infestation 11.4 F2 F3 SERPINC1
19 antipyrine metabolism 11.4 ALB F2
20 congenital hypogammaglobulinemia 11.4 CD40LG CD79A IL4
21 parasitic ichthyosporea infectious disease 11.4 CD40LG CD79A IL4
22 orbital granuloma 11.4 CD40LG CD79A CSF3
23 von willebrand disease, type 1 11.4 F2 F3 VWF
24 giant hemangioma 11.4 F2 F3 SERPINC1
25 rhinosporidiosis 11.4 CD40LG CD79A IL4
26 cerebral sinovenous thrombosis 11.4 APOH F2 F3
27 hantavirus pulmonary syndrome 11.4 CD40LG F2 F3
28 non-a-e hepatitis 11.4 ALB F2
29 primary thrombocytopenia 11.4 CD40LG CD79A VWF
30 polyclonal hypergammaglobulinemia 11.4 CD40LG CD79A IL6
31 sagittal sinus thrombosis 11.4 F2 F3 SERPINC1
32 blue toe syndrome 11.4 F2 F3 SERPINC1
33 prothrombin deficiency, congenital 11.4 APOH F2 SERPINC1
34 autoimmune disease of blood 11.4 CD40LG CD79A VWF
35 intracranial embolism 11.4 F2 F3 SERPINC1
36 immunodeficiency with hyper-igm, type 1 11.3 CD40LG CD79A IL4
37 sudden sensorineural hearing loss 11.3 F2 IL6 SERPINC1
38 diffuse glomerulonephritis 11.3 ALB CD40LG CD79A
39 catastrophic antiphospholipid syndrome 11.3 APOH CD40LG F3
40 jejunoileitis 11.3 CD40LG CD79A TNF
41 cough variant asthma 11.3 IL4 IL5 TRPV1
42 meningovascular neurosyphilis 11.3 CD40LG CD79A
43 ischemic colitis 11.3 APOH F2 SERPINC1
44 alpha chain disease 11.3 CD40LG CD79A
45 acute salpingitis 11.3 CD40LG CD79A TNF
46 brill-zinsser disease 11.3 CD40LG CD79A
47 critical limb ischemia 11.3 IL6 TNF VWF
48 non-secretory myeloma 11.3 ALB CD40LG CD79A
49 colorado tick fever 11.3 ALB CD40LG
50 exudative glomerulonephritis 11.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Immune System Disease:



Diseases related to Immune System Disease

Symptoms & Phenotypes for Immune System Disease

UMLS symptoms related to Immune System Disease:


pathological conditions, signs and symptoms

GenomeRNAi Phenotypes related to Immune System Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ISG15 SERPINC1 TLR9 ALB CD79A CSF3

MGI Mouse Phenotypes related to Immune System Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 IL6 IL4 SERPINC1 TF IL5 TLR9
2 hematopoietic system MP:0005397 10.33 IL6 IL2 IL4 SERPINC1 TF IL5
3 immune system MP:0005387 10.31 IL6 TNF IL4 ISG15 SERPINC1 IL5
4 cellular MP:0005384 10.27 TLR9 IL6 IL2 IL4 EPO ALB
5 cardiovascular system MP:0005385 10.21 IL2 IL6 SERPINC1 EPO F2 CD40LG
6 digestive/alimentary MP:0005381 10.13 TLR9 IL6 IL2 IL4 IL5 F2
7 mortality/aging MP:0010768 10.1 TLR9 IL6 IL2 IL4 SERPINC1 TF
8 integument MP:0010771 10.02 IL6 IL4 EPO F2 CD40LG F3
9 liver/biliary system MP:0005370 10.02 IL6 IL2 IL4 SERPINC1 IL5 CD79A
10 neoplasm MP:0002006 9.76 IL5 IL6 IL2 ALB F3 CD79A
11 renal/urinary system MP:0005367 9.61 TLR9 IL6 IL4 SERPINC1 CD40LG CD79A
12 respiratory system MP:0005388 9.23 IL5 IL2 IL6 IL4 EPO F2

Drugs & Therapeutics for Immune System Disease

Drugs for Immune System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1349)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1 59467-70-8 4192
2
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
3
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
4
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
5
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
6
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
7
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
8
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 155213-67-5 392622
9
Fludrocortisone Approved, Investigational Phase 4 127-31-1 31378
10
Simvastatin Approved Phase 4,Phase 2,Phase 1,Not Applicable 79902-63-9 54454
11
4-Aminopyridine Approved Phase 4,Phase 3 504-24-5 1727
12
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 111025-46-8 4829
13
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 7782-49-2
14
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 242138-07-4
15
Linagliptin Approved Phase 4,Not Applicable 668270-12-0 10096344
16
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
17
Voglibose Approved, Investigational Phase 4 83480-29-9 444020
18
Enalapril Approved, Vet_approved Phase 4,Phase 2,Not Applicable 75847-73-3 5362032 40466924
19
Enalaprilat Approved Phase 4,Phase 2,Not Applicable 76420-72-9 6917719
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
22
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
23
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
24
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6 23994
25
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53608-75-6
26
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
27
Losartan Approved Phase 4,Phase 3,Phase 2,Not Applicable 114798-26-4 3961
28
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 116094-23-6 16132418
29
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
30
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
31
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
32
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75614-87-8, 51-45-6 774
33
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 439542 10909430
34
Bronopol Approved Phase 4 52-51-7
35
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-23-7 5754
36 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
37
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
38
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
39
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 299-42-3 9294
40
Naphazoline Approved Phase 4,Phase 3 835-31-4 4436
41
Pheniramine Approved Phase 4,Phase 3 86-21-5 4761
42
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90-82-4 7028
43
Glyburide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10238-21-8 3488
44
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83881-51-0 2678
45
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
46
Levocetirizine Approved Phase 4,Phase 3,Phase 1,Phase 2 130018-77-8 1549000
47
Azathioprine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 446-86-6 2265
48
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
49
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 104987-11-3 445643 439492
50
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
2 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
3 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
4 TRPV Expression in Subjects With Sensitive Skin Unknown status NCT01871883 Phase 4
5 Safety of Ertapenem in Beta-lactam Allergic Patients. Unknown status NCT01159379 Phase 4 ertapenem
6 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
7 Growth, Safety and Tolerance of a Rice Protein Hydrolysate Formula in Infants With Cow's Milk Protein Allergy Unknown status NCT02405923 Phase 4
8 Fludrocortisone's Test in Salt Sensitivity Unknown status NCT01453959 Phase 4 Fludrocortisone
9 Can we Help People With the Oral Allergy Syndrome Eat Fresh Fruit? Unknown status NCT01431859 Phase 4
10 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
11 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
12 Short and Long Term Multiple Outcomes in Persons With Multiple Sclerosis Treated by Fampridine. Unknown status NCT02849782 Phase 4 Fampridine
13 Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity Unknown status NCT01736202 Phase 4
14 Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD Unknown status NCT01253928 Phase 4 Pioglitazone
15 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
16 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
17 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
18 Effect of Xolair on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4 Omalizumab;Placebo for Omalizumab;omalizumab
19 Diagnostic Immunization With Rabies Vaccine in Patients With PID Unknown status NCT02490956 Phase 4
20 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
21 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
22 The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes Unknown status NCT02307695 Phase 4 Saxagliptin;Insulin
23 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
24 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
25 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
26 Ocular Allergy Treatment Practical Impact Trial Unknown status NCT01808768 Phase 4 Alcaftadine
27 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
28 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
29 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
30 Comparison of Tolerability Between Two Allergy Drops Unknown status NCT01390961 Phase 4 alacaftadine and naphazoline HCl & pheniramine maleate
31 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer Unknown status NCT01346371 Phase 4 Bepreve (bepotastine ophthalmic solution) 1.5%
32 Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses Unknown status NCT01337557 Phase 4 Bepotastine
33 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
34 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
35 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
36 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
37 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
38 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
39 The Efficacy and Safety of Desloratadine With Levocetirizine in Treatment of Chronic Idiopathic Urticaria Unknown status NCT00346606 Phase 4 Denosin® and Xyzal®
40 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
41 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
42 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Unknown status NCT00128895 Phase 4 azathioprine
43 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
44 The Clinical Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months Treatment Unknown status NCT02837978 Phase 4 Tacrolimus;MTX
45 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
46 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
47 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
48 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4 Dapagliflozin
49 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
50 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide

Search NIH Clinical Center for Immune System Disease

Genetic Tests for Immune System Disease

Genetic tests related to Immune System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Immune System 29

Anatomical Context for Immune System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Immune System Disease:

19
The Immune System

MalaCards organs/tissues related to Immune System Disease:

41
B Cells, T Cells, Testes, Bone, Bone Marrow, Skin, Pancreas

Publications for Immune System Disease

Variations for Immune System Disease

Expression for Immune System Disease

Search GEO for disease gene expression data for Immune System Disease.

Pathways for Immune System Disease

Pathways related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CD40LG CSF3 EPO F2 IL2 IL4
2
Show member pathways
13.39 CD40LG CSF3 IL2 IL4 IL5 IL6
3
Show member pathways
13.34 CD40LG CSF3 IL2 IL4 IL5 IL6
4
Show member pathways
13.29 CD40LG CSF3 IL2 IL4 IL5 IL6
5
Show member pathways
13.28 ALB APOH F2 F3 IL2 IL5
6
Show member pathways
12.92 CSF3 EPO IL2 IL4 IL6 ISG15
7
Show member pathways
12.87 CD40LG IL2 IL4 IL5 IL6 TNF
8
Show member pathways
12.77 IL2 IL4 IL6 TLR9 TNF
9
Show member pathways
12.69 CD40LG IL2 IL6 TLR9 TNF
10 12.55 CD40LG CD79A IL2 IL4 TLR9 TNF
11
Show member pathways
12.44 IL2 IL4 IL5 IL6 TNF
12
Show member pathways
12.4 CD40LG IL2 IL4 IL5 IL6 TNF
13
Show member pathways
12.35 CSF3 EPO IL2 IL4 IL5 IL6
14
Show member pathways
12.34 CSF3 IL4 IL5 IL6 TNF
15
Show member pathways
12.27 ALB F2 IL2 IL4 IL6 TNF
16
Show member pathways
12.24 IL2 IL6 TLR9 TNF
17
Show member pathways
12.2 IL2 IL6 TLR9 TNF
18
Show member pathways
12.18 IL4 IL6 TLR9 TNF
19
Show member pathways
12.15 F2 F3 SERPINC1 VWF
20 12.08 F2 F3 SERPINC1 VWF
21 12 IL2 IL4 IL6 TNF
22 11.81 IL2 IL4 IL5 IL6
23 11.8 IL2 IL4 IL5 TNF
24 11.75 IL2 IL6 TLR9 TNF
25 11.72 CSF3 EPO IL4 IL5 IL6 TNF
26
Show member pathways
11.68 CD40LG IL2 IL4 IL5 TNF
27
Show member pathways
11.67 CD40LG IL2 IL6 TNF
28 11.65 CD40LG IL4 IL5
29 11.57 CSF3 IL4 IL5 IL6 TNF
30 11.55 IL2 IL6 TNF
31 11.53 CSF3 IL4 IL6 TNF
32 11.51 EPO IL6 TF
33 11.51 CSF3 EPO IL5 IL6
34 11.48 IL2 IL4 IL5
35 11.41 CD40LG CSF3 IL6 TLR9 TNF
36 11.35 IL6 TLR9 TNF
37 11.3 CD40LG IL2 IL4 IL5
38 11.29 CD79A CSF3 EPO IL2 IL4 IL5
39 11.24 IL4 IL5 IL6 TNF
40 11.2 IL2 IL4 IL5
41 10.91 CSF3 IL2 IL4 IL5 IL6 TNF

GO Terms for Immune System Disease

Cellular components related to Immune System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.83 ALB APOH CD40LG CSF3 EPO F2
2 cell surface GO:0009986 9.8 APOH CD40LG EPO F3 TF TNF
3 blood microparticle GO:0072562 9.67 ALB F2 SERPINC1 TF
4 endoplasmic reticulum lumen GO:0005788 9.65 ALB F2 IL6 SERPINC1 TF
5 external side of plasma membrane GO:0009897 9.55 CD40LG CD79A F2 TNF TRPV1
6 extracellular region GO:0005576 9.55 ALB APOH CD40LG CSF3 EPO F2

Biological processes related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 CD40LG IL5 IL6 TLR9 TNF TRPV1
2 blood coagulation GO:0007596 9.92 F2 F3 SERPINC1 VWF
3 cellular protein metabolic process GO:0044267 9.91 ALB F2 IL6 SERPINC1 TF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 CD40LG IL6 TLR9 TNF
5 platelet degranulation GO:0002576 9.86 ALB APOH TF VWF
6 platelet activation GO:0030168 9.85 CD40LG F2 IL6 VWF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 CSF3 IL5 IL6 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 CSF3 IL6 TNF
9 B cell differentiation GO:0030183 9.82 CD40LG CD79A IL4
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 EPO IL2 IL6
11 immune response GO:0006955 9.8 CD40LG CSF3 IL2 IL4 IL5 IL6
12 positive regulation of interleukin-6 production GO:0032755 9.78 IL6 TLR9 TNF
13 acute-phase response GO:0006953 9.75 EPO F2 IL6
14 positive regulation of T cell proliferation GO:0042102 9.73 CD40LG IL2 IL4 IL6
15 positive regulation of JAK-STAT cascade GO:0046427 9.7 F2 IL5 IL6
16 positive regulation of podosome assembly GO:0071803 9.65 IL5 TNF
17 negative regulation of fibrinolysis GO:0051918 9.65 APOH F2
18 positive regulation of chemokine production GO:0032722 9.65 IL6 TLR9 TNF
19 negative regulation of lipid storage GO:0010888 9.64 IL6 TNF
20 response to salt stress GO:0009651 9.63 EPO TNF
21 positive regulation of isotype switching to IgG isotypes GO:0048304 9.63 IL2 IL4
22 blood coagulation, intrinsic pathway GO:0007597 9.63 APOH F2 VWF
23 hemostasis GO:0007599 9.62 F2 F3 SERPINC1 VWF
24 negative regulation of myeloid cell apoptotic process GO:0033033 9.61 APOH EPO
25 regulation of immunoglobulin secretion GO:0051023 9.6 CD40LG TNF
26 regulation of blood coagulation GO:0030193 9.58 APOH F2 SERPINC1
27 positive regulation of immunoglobulin secretion GO:0051024 9.54 IL2 IL5 IL6
28 cytokine-mediated signaling pathway GO:0019221 9.5 CSF3 F3 IL2 IL4 IL5 IL6
29 positive regulation of B cell proliferation GO:0030890 9.46 IL2 IL4 IL5 TLR9
30 regulation of signaling receptor activity GO:0010469 9.28 CD40LG CSF3 EPO F2 IL2 IL4
31 negative regulation of apoptotic process GO:0043066 10.06 ALB CD40LG EPO IL2 IL4 IL6
32 positive regulation of cell proliferation GO:0008284 10.04 CSF3 EPO F2 IL2 IL5 IL6

Molecular functions related to Immune System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.46 F3 SERPINC1 TNF VWF
2 growth factor activity GO:0008083 9.43 CSF3 F2 IL2 IL4 IL5 IL6
3 cytokine activity GO:0005125 9.23 CD40LG CSF3 EPO IL2 IL4 IL5
4 protein binding GO:0005515 10.21 ALB APOH CD40LG CD79A EPO F2

Sources for Immune System Disease

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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38 LifeMap
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44 MeSH
45 MESH via Orphanet
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49 NCI
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55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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