Immune System Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Immune System Organ Benign Neoplasm

MalaCards integrated aliases for Immune System Organ Benign Neoplasm:

Name: Immune System Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060092

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Summaries for Immune System Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm located in the immune system organs.

MalaCards based summary : Immune System Organ Benign Neoplasm is related to mesenchymoma and endolymphatic sac tumor. An important gene associated with Immune System Organ Benign Neoplasm is MB (Myoglobin), and among its related pathways/superpathways are NF-kappaB Signaling and Cytoskeletal Signaling. Affiliated tissues include the immune system organs.

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Related Diseases for Immune System Organ Benign Neoplasm

Diseases related to Immune System Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)

#	Related Disease	Score	Top Affiliating Genes
1	mesenchymoma	10.9	HMGA2 MB
2	endolymphatic sac tumor	10.9	KRT7 KRT8
3	cystic basal cell carcinoma	10.9	KRT20 KRT7
4	vaginal benign neoplasm	10.9	KRT20 KRT7
5	seminal vesicle adenocarcinoma	10.9	KRT20 KRT7
6	transverse colon cancer	10.9	KRT20 KRT7
7	appendix adenocarcinoma	10.9	KRT20 KRT7
8	vaginal adenoma	10.9	KRT20 KRT7
9	vaginal tubulovillous adenoma	10.9	KRT20 KRT7
10	eyelid neoplasm	10.8	KRT20 KRT7
11	glandular cystitis	10.8	KRT20 KRT7
12	malignant syringoma	10.8	KRT20 KRT7
13	cervical adenoma malignum	10.8	HMGA2 KRT7
14	krukenberg carcinoma	10.8	KRT20 KRT7
15	large intestine adenocarcinoma	10.8	KRT20 KRT7
16	hidrocystoma	10.8	KRT7 KRT8
17	linitis plastica	10.8	KRT20 KRT7
18	lung acinar adenocarcinoma	10.8	KRT20 KRT7
19	adenoma of the pancreas	10.8	KRT20 SYP
20	myofibroma	10.8	CD1A MB
21	adenoid squamous cell carcinoma	10.8	KRT20 KRT7
22	eccrine sweat gland neoplasm	10.8	KRT20 KRT7
23	ovary neuroendocrine neoplasm	10.8	KRT7 SYP
24	apocrine sweat gland neoplasm	10.8	KRT7 KRT8
25	mucinous bronchioloalveolar adenocarcinoma	10.8	KRT20 KRT7
26	cutaneous ganglioneuroma	10.8	KRT20 SYP
27	cervical mucinous adenocarcinoma	10.8	HMGA2 KRT7
28	nodular tenosynovitis	10.8	HMGA2 PTPRC
29	sarcomatoid squamous cell skin carcinoma	10.7	MB PTPRC
30	sensory organ benign neoplasm	10.7	KRT7 SYP
31	nasal cavity cancer	10.7	KRT7 KRT8
32	kidney rhabdoid cancer	10.7	MB PTPRC
33	ovarian mucinous adenocarcinoma	10.7	KRT20 KRT7
34	middle ear adenoma	10.7	KRT7 SYP
35	gastric diffuse adenocarcinoma	10.7	KRT20 KRT7
36	papillary serous adenocarcinoma	10.7	KRT20 KRT7
37	epithelioid sarcoma	10.7	KRT7 KRT8 MB
38	mixed type thymoma	10.7	CD5 SYP
39	extraosseous osteosarcoma	10.6	KRT7 PTPRC
40	bladder adenocarcinoma	10.6	KRT20 KRT7
41	lymphoepithelioma-like carcinoma	10.6	KRT20 KRT7 KRT8
42	mammary paget's disease	10.6	KRT20 KRT7 KRT8
43	jejunal adenocarcinoma	10.6	KRT20 KRT7
44	angiomyoma	10.6	HMGA2 MB SYP
45	vulvar sarcoma	10.6	KRT7 PTPRC
46	chronic cystitis	10.6	KRT20 KRT7
47	water-clear cell adenoma	10.6	PTH SYP
48	cutaneous mucoepidermoid carcinoma	10.6	CEACAM5 KRT7
49	mixed cell type cancer	10.6	KRT7 MB SYP
50	bladder lymphoma	10.6	CD5 KRT20 KRT7

Graphical network of the top 20 diseases related to Immune System Organ Benign Neoplasm:

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Symptoms & Phenotypes for Immune System Organ Benign Neoplasm

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Drugs & Therapeutics for Immune System Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Immune System Organ Benign Neoplasm

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Genetic Tests for Immune System Organ Benign Neoplasm

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Anatomical Context for Immune System Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Immune System Organ Benign Neoplasm:

¹⁹

The Immune System Organs

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Publications for Immune System Organ Benign Neoplasm

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Genes for Immune System Organ Benign Neoplasm

Genes related to Immune System Organ Benign Neoplasm (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MB	Myoglobin	Protein Coding	15.44	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CD8A	CD8a Molecule	Protein Coding	15.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	CD4	CD4 Molecule	Protein Coding	14.98	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	KRT8	Keratin 8	Protein Coding	14.31	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KRT20	Keratin 20	Protein Coding	14.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	14.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CD1A	CD1a Molecule	Protein Coding	14.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	KRT7	Keratin 7	Protein Coding	13.69	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	CD5	CD5 Molecule	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	SYP	Synaptophysin	Protein Coding	13.58	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.45	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	PTH	Parathyroid Hormone	Protein Coding	13.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	CD1B	CD1b Molecule	Protein Coding	5.51	DISEASES inferred ¹⁵
14	CD1C	CD1c Molecule	Protein Coding	4.6	DISEASES inferred ¹⁵
15	KRT19	Keratin 19	Protein Coding	3.8	DISEASES inferred ¹⁵
16	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	3.54	DISEASES inferred ¹⁵
17	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	3.04	DISEASES inferred ¹⁵

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Variations for Immune System Organ Benign Neoplasm

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Expression for Immune System Organ Benign Neoplasm

Search GEO for disease gene expression data for Immune System Organ Benign Neoplasm.

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Pathways for Immune System Organ Benign Neoplasm

Pathways related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	12.33	CD8A CEACAM5 PTPRC TNFRSF8
2	Cytoskeletal Signaling ⁴	12.25	KRT19 KRT20 KRT7 KRT8
3	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.19	KRT19 KRT20 KRT7 KRT8
4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.75	CD1A CD1B CD1C CD8A
5	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.7	KRT19 KRT7 KRT8
6	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.69	CD4 CD8A PTPRC
7	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.52	CD1A CD1C CD4 CD8A PTPRC
8	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.5	CD1C CD4 CD5 CD8A CEACAM5 PTPRC
9	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.48	CD4 CD8A PTPRC
10	B Cell Development Pathways ⁶⁵	11.28	CD1C CD4 CD5 PTPRC TNFRSF8
11	Primary immunodeficiency ³⁷	11.11	CD4 CD8A PTPRC
12	Hematopoietic cell lineage ³⁷	11.09	CD1A CD1B CD1C CD4 CD5 CD8A

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GO Terms for Immune System Organ Benign Neoplasm

Cellular components related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.46	CD4 CD5 CD8A PTPRC
2	apicolateral plasma membrane	GO:0016327	9.4	KRT19 KRT8
3	costamere	GO:0043034	9.37	KRT19 KRT8
4	T cell receptor complex	GO:0042101	9.32	CD4 CD8A
5	dystrophin-associated glycoprotein complex	GO:0016010	9.26	KRT19 KRT8
6	intermediate filament	GO:0005882	9.26	KRT19 KRT20 KRT7 KRT8
7	integral component of plasma membrane	GO:0005887	9.23	CD1A CD1C CD4 CD5 CD8A CEACAM5

Biological processes related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	9.85	CD1A CD1B CD1C CD4 CD8A
2	adaptive immune response	GO:0002250	9.73	CD1A CD1B CD1C CD4
3	regulation of immune response	GO:0050776	9.67	CD1A CD1B CD1C CD8A
4	response to vitamin D	GO:0033280	9.48	CD4 PTH
5	keratinization	GO:0031424	9.46	KRT19 KRT20 KRT7 KRT8
6	positive regulation of stem cell proliferation	GO:2000648	9.4	HMGA2 PTPRC
7	positive regulation of cell proliferation in bone marrow	GO:0071864	9.32	HMGA2 PTH
8	cell differentiation involved in embryonic placenta development	GO:0060706	9.26	KRT19 KRT8
9	cornification	GO:0070268	9.26	KRT19 KRT20 KRT7 KRT8
10	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	8.8	CD1A CD1B CD1C

Molecular functions related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	beta-2-microglobulin binding	GO:0030881	9.43	CD1A CD1B CD1C
2	lipopeptide binding	GO:0071723	9.33	CD1A CD1B CD1C
3	exogenous lipid antigen binding	GO:0030884	9.13	CD1A CD1B CD1C
4	endogenous lipid antigen binding	GO:0030883	8.8	CD1A CD1B CD1C

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