Immune System Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Immune System Organ Benign Neoplasm

MalaCards integrated aliases for Immune System Organ Benign Neoplasm:

Name: Immune System Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060092

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Summaries for Immune System Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm located in the immune system organs.

MalaCards based summary : Immune System Organ Benign Neoplasm is related to hemangioma of spleen and metal allergy. An important gene associated with Immune System Organ Benign Neoplasm is TBL1XR1 (Transducin Beta Like 1 X-Linked Receptor 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include lung, kidney and colon.

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Related Diseases for Immune System Organ Benign Neoplasm

Diseases related to Immune System Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)

#	Related Disease	Score	Top Affiliating Genes
1	hemangioma of spleen	10.3	CD9 TBL1XR1
2	metal allergy	10.3	CD4 CD8A
3	polyclonal hypergammaglobulinemia	10.3	CD4 CD8A
4	mesenchymoma	10.3	HMGA2 MB
5	myofibroma	10.2	CD1A MB
6	endolymphatic sac tumor	10.2	KRT7 KRT8
7	bile duct adenoma	10.2	KRT20 KRT7
8	cystic basal cell carcinoma	10.2	KRT20 KRT7
9	seminal vesicle adenocarcinoma	10.2	KRT20 KRT7
10	transverse colon cancer	10.2	KRT20 KRT7
11	appendix adenocarcinoma	10.2	KRT20 KRT7
12	malignant syringoma	10.2	KRT20 KRT7
13	glandular cystitis	10.2	KRT20 KRT7
14	orbital cancer	10.2	MB SYP
15	papillary transitional carcinoma	10.2	KRT20 KRT7
16	eyelid carcinoma	10.2	KRT20 KRT7
17	krukenberg carcinoma	10.2	KRT20 KRT7
18	large intestine adenocarcinoma	10.2	KRT20 KRT7
19	hidrocystoma	10.2	KRT7 KRT8
20	ovarian large-cell neuroendocrine carcinoma	10.2	KRT20 SYP
21	linitis plastica	10.2	KRT20 KRT7
22	cervical adenoma malignum	10.2	HMGA2 KRT7
23	lung acinar adenocarcinoma	10.2	KRT20 KRT7
24	apocrine sweat gland neoplasm	10.2	KRT7 KRT8
25	adenoma of the pancreas	10.2	KRT20 SYP
26	rhabdoid cancer	10.2	MB SYP
27	vulval paget's disease	10.2	KRT20 KRT7
28	cutaneous ganglioneuroma	10.2	KRT20 SYP
29	cervical mucinous adenocarcinoma	10.2	HMGA2 KRT7
30	bile duct cystadenocarcinoma	10.2	KRT20 KRT7
31	nasal cavity cancer	10.2	KRT7 KRT8
32	kidney rhabdoid cancer	10.2	MB PTPRC
33	jejunal adenocarcinoma	10.2	KRT20 KRT7
34	nodular tenosynovitis	10.2	HMGA2 PTPRC
35	ovarian mucinous adenocarcinoma	10.2	KRT20 KRT7
36	appendix disease	10.2	KRT20 KRT7
37	ovary neuroendocrine neoplasm	10.2	KRT7 SYP
38	gastric diffuse adenocarcinoma	10.2	KRT20 KRT7
39	ectopic thymus	10.2	CD5 SYP
40	meibomian cyst	10.2	KRT20 KRT7
41	papillary serous adenocarcinoma	10.2	KRT20 KRT7
42	mucinous adenofibroma	10.2	KRT7 SYP
43	bladder adenocarcinoma	10.2	KRT20 KRT7
44	chronic cystitis	10.2	KRT20 KRT7
45	mixed type thymoma	10.2	CD5 SYP
46	vulva adenocarcinoma	10.2	KRT20 KRT7
47	brooke-spiegler syndrome	10.2	KRT7 KRT8
48	sensory organ benign neoplasm	10.2	KRT7 SYP
49	middle ear adenoma	10.2	KRT7 SYP
50	epithelioid sarcoma	10.2	KRT7 KRT8 MB

Graphical network of the top 20 diseases related to Immune System Organ Benign Neoplasm:

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Symptoms & Phenotypes for Immune System Organ Benign Neoplasm

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Drugs & Therapeutics for Immune System Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Immune System Organ Benign Neoplasm

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Genetic Tests for Immune System Organ Benign Neoplasm

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Anatomical Context for Immune System Organ Benign Neoplasm

MalaCards organs/tissues related to Immune System Organ Benign Neoplasm:

⁴¹

Lung, Kidney, Colon, Ovary, Spleen, Thymus, Appendix

The Foundational Model of Anatomy Ontology organs/tissues related to Immune System Organ Benign Neoplasm:

¹⁹

The Immune System Organs

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Publications for Immune System Organ Benign Neoplasm

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Genes for Immune System Organ Benign Neoplasm

Genes related to Immune System Organ Benign Neoplasm (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TBL1XR1	Transducin Beta Like 1 X-Linked Receptor 1	Protein Coding	15.49	DISEASES inferred ¹⁵
2	MB	Myoglobin	Protein Coding	15.27	DISEASES inferred ¹⁵
3	CD8A	CD8a Molecule	Protein Coding	14.9	DISEASES inferred ¹⁵
4	CD4	CD4 Molecule	Protein Coding	14.8	DISEASES inferred ¹⁵
5	CD9	CD9 Molecule	Protein Coding	14.36	DISEASES inferred ¹⁵
6	KRT8	Keratin 8	Protein Coding	14.04	DISEASES inferred ¹⁵
7	KRT20	Keratin 20	Protein Coding	14.01	DISEASES inferred ¹⁵
8	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	13.98	DISEASES inferred ¹⁵
9	CD1A	CD1a Molecule	Protein Coding	13.89	DISEASES inferred ¹⁵
10	CD5	CD5 Molecule	Protein Coding	13.42	DISEASES inferred ¹⁵
11	KRT7	Keratin 7	Protein Coding	13.4	DISEASES inferred ¹⁵
12	SYP	Synaptophysin	Protein Coding	13.33	DISEASES inferred ¹⁵
13	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.25	DISEASES inferred ¹⁵
14	CD1B	CD1b Molecule	Protein Coding	5.27	DISEASES inferred ¹⁵
15	CD1C	CD1c Molecule	Protein Coding	4.37	DISEASES inferred ¹⁵
16	KRT19	Keratin 19	Protein Coding	3.5	DISEASES inferred ¹⁵
17	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	3.36	DISEASES inferred ¹⁵

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Variations for Immune System Organ Benign Neoplasm

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Expression for Immune System Organ Benign Neoplasm

Search GEO for disease gene expression data for Immune System Organ Benign Neoplasm.

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Pathways for Immune System Organ Benign Neoplasm

Pathways related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	12.25	KRT19 KRT20 KRT7 KRT8
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.19	KRT19 KRT20 KRT7 KRT8
3	Cell adhesion molecules (CAMs) ³⁷	11.84	CD4 CD8A PTPRC
4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.75	CD1A CD1B CD1C CD8A
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.72	CD1C CD4 CD5 CD8A PTPRC
6	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.7	KRT19 KRT7 KRT8
7	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.69	CD4 CD8A PTPRC
8	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.48	CD4 CD8A PTPRC
9	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.42	CD1A CD1C CD4 CD8A PTPRC
10	Hematopoietic cell lineage ³⁷	11.15	CD1A CD1B CD1C CD4 CD5 CD8A
11	Primary immunodeficiency ³⁷	11.11	CD4 CD8A PTPRC
12	B Cell Development Pathways ⁶⁵	11.08	CD1C CD4 CD5 PTPRC TNFRSF8

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GO Terms for Immune System Organ Benign Neoplasm

Cellular components related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.87	CD1A CD1C CD4 CD5 CD8A CD9
2	apicolateral plasma membrane	GO:0016327	9.46	KRT19 KRT8
3	intermediate filament	GO:0005882	9.46	KRT19 KRT20 KRT7 KRT8
4	costamere	GO:0043034	9.43	KRT19 KRT8
5	cell periphery	GO:0071944	9.43	KRT19 KRT8 PTPRC
6	dystrophin-associated glycoprotein complex	GO:0016010	9.4	KRT19 KRT8
7	T cell receptor complex	GO:0042101	9.37	CD4 CD8A
8	external side of plasma membrane	GO:0009897	9.35	CD4 CD5 CD8A CD9 PTPRC
9	cell surface	GO:0009986	9.1	CD1A CD1B CD1C CD4 CD9 PTPRC

Biological processes related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	9.91	CD1A CD1B CD1C CD4 CD8A
2	immune response	GO:0006955	9.85	CD1A CD1B CD1C CD4 CD8A
3	adaptive immune response	GO:0002250	9.84	CD1A CD1B CD1C CD4
4	cell surface receptor signaling pathway	GO:0007166	9.8	CD4 CD8A CD9 PTPRC
5	regulation of immune response	GO:0050776	9.73	CD1A CD1B CD1C CD8A
6	keratinization	GO:0031424	9.71	KRT19 KRT20 KRT7 KRT8
7	cornification	GO:0070268	9.56	KRT19 KRT20 KRT7 KRT8
8	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.52	CD4 PTPRC
9	T cell activation	GO:0042110	9.5	CD4 CD8A PTPRC
10	positive regulation of stem cell proliferation	GO:2000648	9.48	HMGA2 PTPRC
11	cell differentiation involved in embryonic placenta development	GO:0060706	9.37	KRT19 KRT8
12	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.33	CD1A CD1B CD1C
13	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	9.13	CD1A CD1B CD1C
14	positive regulation of T cell mediated cytotoxicity	GO:0001916	8.92	CD1A CD1B CD1C PTPRC

Molecular functions related to Immune System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopeptide binding	GO:0071723	9.33	CD1A CD1B CD1C
2	endogenous lipid antigen binding	GO:0030883	9.13	CD1A CD1B CD1C
3	exogenous lipid antigen binding	GO:0030884	8.8	CD1A CD1B CD1C

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