MCID: IMM137
MIFTS: 18

Immunodeficiency with Thymoma

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Immunodeficiency with Thymoma

MalaCards integrated aliases for Immunodeficiency with Thymoma:

Name: Immunodeficiency with Thymoma 53 72
Thymoma-Immunodeficiency Syndrome 53
Good Syndrome 53

Classifications:



External Ids:

UMLS 72 C0221027

Summaries for Immunodeficiency with Thymoma

NIH Rare Diseases : 53 Good syndrome is a rare, adult-onset primary immunodeficiency suspected in patients who exhibit hypogammaglobulinemia and low levels of B cells along with a benign thymic tumor (thymoma) on chest X-ray. Symptoms include frequent opportunistic infections involving the sinuses and lungs, including severe CMV disease, P. carinii pneumonia, and mucocutaneous candidiasis. While the cause of Good syndrome remains unknown, there is some evidence that a defect of the bone marrow is involved. Treatment includes removal of the thymic tumor and immunoglobulin replacement.

MalaCards based summary : Immunodeficiency with Thymoma, also known as thymoma-immunodeficiency syndrome, is related to chronic granulomatous disease and good syndrome. Affiliated tissues include b cells, lung and bone.

Wikipedia : 75 Thymoma with immunodeficiency (also known as "Good syndrome") is a rare disorder that occurs in adults... more...

Related Diseases for Immunodeficiency with Thymoma

Diseases related to Immunodeficiency with Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 chronic granulomatous disease 11.7
2 good syndrome 11.7
3 thymoma, familial 10.3
4 thymoma 10.3
5 immune deficiency disease 10.3
6 candidiasis 10.1
7 agammaglobulinemia 10.1
8 cd4/cd8 t-cell ratio 10.0
9 common variable immunodeficiency 10.0
10 lymphopenia 10.0
11 herpes simplex 9.9
12 kaposi sarcoma 9.8
13 leukemia, chronic lymphocytic 9.8
14 myasthenia gravis 9.8
15 myeloma, multiple 9.8
16 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.8
17 inflammatory bowel disease 9.8
18 cytomegalovirus retinitis 9.8
19 cutaneous candidiasis 9.8
20 neuroretinitis 9.8
21 lymphocytic leukemia 9.8
22 horner's syndrome 9.8
23 esophageal candidiasis 9.8
24 pure red-cell aplasia 9.8
25 spindle cell thymoma 9.8
26 retinitis 9.8
27 combined t cell and b cell immunodeficiency 9.8
28 acquired immunodeficiency syndrome 9.8
29 chickenpox 9.8
30 lichen planus 9.8
31 bronchiectasis 9.8
32 haemophilus influenzae 9.8
33 leukemia, b-cell, chronic 9.8
34 paraneoplastic syndromes 9.8
35 thymoma type a 9.8
36 red cell aplasia 9.8
37 autoimmune disease 9.8
38 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
39 diarrhea 9.8
40 panbronchiolitis, diffuse 9.8
41 bacterial infectious disease 9.8
42 neutropenia 9.8
43 thymic carcinoma 9.8
44 pneumonia 9.8
45 oral lichen planus 9.8
46 bacterial pneumonia 9.7
47 cytomegalovirus infection 9.7
48 keratitis, hereditary 9.5
49 otitis media 9.5
50 retinal detachment 9.5

Graphical network of the top 20 diseases related to Immunodeficiency with Thymoma:



Diseases related to Immunodeficiency with Thymoma

Symptoms & Phenotypes for Immunodeficiency with Thymoma

Drugs & Therapeutics for Immunodeficiency with Thymoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Association of Depression With "Motoric Cognitive Risk" Syndrome in the Canadian Population Active, not recruiting NCT03679221

Search NIH Clinical Center for Immunodeficiency with Thymoma

Genetic Tests for Immunodeficiency with Thymoma

Anatomical Context for Immunodeficiency with Thymoma

MalaCards organs/tissues related to Immunodeficiency with Thymoma:

41
B Cells, Lung, Bone, Bone Marrow, T Cells

Publications for Immunodeficiency with Thymoma

Articles related to Immunodeficiency with Thymoma:

(show all 15)
# Title Authors PMID Year
1
Good's syndrome remains a mystery after 55 years: A systematic review of the scientific evidence. 6
20149753 2010
2
Acquired immunodeficiency associated with thymoma: a case report. 38
31375083 2019
3
Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report. 38
29512373 2018
4
Persistence of immunological alterations after thymectomy in Good's syndrome: a clue to its pathogenesis. 38
21520407 2011
5
A case of Good's syndrome: a rare acquired immunodeficiency associated with thymoma. 38
21587135 2011
6
Severe T- and B-cell immune deficiency associated with malignant thymoma. 38
14692437 2003
7
Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. 38
11307588 2001
8
[Good syndrome, immunodeficiency with thymoma]. 38
11212783 2000
9
Thymoma and cellular immune deficiency in an adolescent. 38
9560844 1998
10
[Immunodeficiency with thymoma (Good's syndrome) similar to sino-bronchial syndrome]. 38
8810767 1996
11
[Good syndrome: immunodeficiency with thymoma]. 38
8007165 1994
12
Fatal varicella infection in a child associated with thymoma and immunodeficiency (Good's syndrome). 38
2329970 1990
13
Characteristics of suppressor cell activity appearing in cocultures of two individuals with immunodeficiency with thymoma. 38
9537024 1980
14
[On a case of immunodeficiency with thymoma (Good syndrome) associated with chronic muco-cutaneous candidiasis (author's transl)]. 38
314534 1979
15
Immunodeficiency with thymoma: failure to induce Ig production in immunodeficient lymphocytes cocultured with normal T cells. 38
310851 1979

Variations for Immunodeficiency with Thymoma

Expression for Immunodeficiency with Thymoma

Search GEO for disease gene expression data for Immunodeficiency with Thymoma.

Pathways for Immunodeficiency with Thymoma

GO Terms for Immunodeficiency with Thymoma

Sources for Immunodeficiency with Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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