Immunoglobulin Alpha Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IMM003 MIFTS: 44	Immunoglobulin Alpha Deficiency Categories: Genetic diseases, Immune diseases
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Aliases & Classifications for Immunoglobulin Alpha Deficiency

MalaCards integrated aliases for Immunoglobulin Alpha Deficiency:

Name: Immunoglobulin Alpha Deficiency ¹² ¹⁵

Iga Deficiency ¹² ⁷⁴ ⁵⁴ ⁴⁴

Immunoglobulin a Deficiency ⁷¹

Gamma-a-Globulin Deficiency ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060025

MeSH ⁴⁴ D017098

SNOMED-CT ⁶⁷ 29260007

UMLS ⁷¹ C0162538

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Summaries for Immunoglobulin Alpha Deficiency

Disease Ontology : ¹² A B cell deficiency that is an autosomal recessive disorder that has material basis in mutation in the IgA (CD79 alpha) antigen receptor.

MalaCards based summary : Immunoglobulin Alpha Deficiency, also known as iga deficiency, is related to primary agammaglobulinemia and glomerulonephritis. An important gene associated with Immunoglobulin Alpha Deficiency is TNFRSF13B (TNF Receptor Superfamily Member 13B), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Immunologic Factors and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and t cells, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁴ Selective immunoglobulin A (IgA) deficiency (SIgAD) is a genetic immunodeficiency, a type of... more...

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Related Diseases for Immunoglobulin Alpha Deficiency

Diseases related to Immunoglobulin Alpha Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 530)

#	Related Disease	Score	Top Affiliating Genes
1	primary agammaglobulinemia	31.0	TNFRSF13C TNFRSF13B
2	glomerulonephritis	30.9	MBL2 CD79A CD40LG C4A
3	lupus erythematosus	30.7	TNFRSF13C HLA-DQB1 CD40LG C4A
4	agammaglobulinemia	30.7	TNFRSF13B ICOSLG CD79A CD40LG CD19
5	transient hypogammaglobulinemia	30.6	TNFRSF13B CD19
6	spondyloarthropathy 1	30.6	ICOSLG HP CD40LG CCR6
7	vitiligo-associated multiple autoimmune disease susceptibility 1	30.5	ICOSLG CD4 CCR6
8	sarcoidosis 1	30.4	ICOSLG HLA-DQB1 CD4 CCR6
9	thrombocytopenic purpura, autoimmune	30.4	ICOSLG CD4 CCR6
10	immunoglobulin g deficiency	30.4	MBL2 CD79A CD40LG
11	systemic scleroderma	30.4	ICOSLG CD40LG CD4 CCR6
12	dysgammaglobulinemia	30.4	TNFRSF13B ICOSLG CD79A
13	respiratory papillomatosis, juvenile recurrent, congenital	30.4	MBL2 CD79A CD40LG
14	vasculitis	30.4	TNFSF13B MBL2 CD79A CD40LG
15	transient hypogammaglobulinemia of infancy	30.4	TNFRSF13C TNFRSF13B CD19
16	bacterial infectious disease	30.3	MBL2 ICOSLG CD4 CCR6 C4A
17	chronic graft versus host disease	30.3	TNFSF13B CD79A
18	evans' syndrome	30.1	HP CD4 CCR6
19	sjogren syndrome	30.1	TNFSF13B CD79A CD40LG
20	dermatitis herpetiformis	30.1	TGM2 HLA-DQB1 CD79A
21	guillain-barre syndrome	30.1	HP HLA-DQB1 CD79A
22	chickenpox	30.1	ICOSLG CD4 CD19 CCR6
23	giardiasis	30.1	TOR1A TGM2 PIGR CD79A CD4
24	connective tissue disease	30.0	TNFSF13B ICOSLG CD40LG CD4 CCR6
25	thrombocytopenia	30.0	TNFSF13B TNFRSF13C TNFRSF13B MBL2 HP CD79A
26	cryoglobulinemia	30.0	TNFSF13B CD79A CD40LG
27	microscopic colitis	30.0	TOR1A TGM2 HLA-DQB1 CD79A
28	granulomatous hepatitis	30.0	TNFRSF13B CD4
29	b cell deficiency	30.0	TOR1A TNFSF13B TNFRSF13C TNFRSF13B TGM2 ICOSLG
30	disease by infectious agent	30.0	MBL2 ICOSLG HP CD4 CCR6
31	duodenitis	29.9	TOR1A TGM2 CD4
32	scabies	29.9	MBL2 CD4 CCR6
33	crohn's disease	29.9	ICOSLG HP CD4 CCR6
34	immunodeficiency, common variable, 2	29.9	TNFRSF13C TNFRSF13B CD19
35	common cold	29.9	ICOSLG CD4 CCR6
36	cryptosporidiosis	29.9	MBL2 CD79A CD40LG CD4
37	monoclonal gammopathy of uncertain significance	29.9	ICOSLG CD19 CCR6
38	iga glomerulonephritis	29.8	PIGR MBL2 CD79A CD40LG CCR6 C4A
39	lymphadenitis	29.8	ICOSLG CD4 CCR6
40	macroglobulinemia	29.8	TNFSF13B TNFRSF13C TNFRSF13B CD40LG
41	celiac disease 1	29.8	TOR1A TNFRSF25 TGM2 ICOSLG HP HLA-DQB1
42	parotid disease	29.8	TNFRSF25 CD4
43	autoimmune disease	29.8	TNFSF13B TNFRSF13C TNFRSF13B TGM2 MBL2 ICOSLG
44	immunoglobulin a deficiency 1	29.7	TOR1A TNFRSF25 TNFRSF13B TGM2 MSH5 CD79A
45	combined immunodeficiency	29.7	ICOSLG CD40LG CD4 CD19 CCR6
46	cholangitis, primary sclerosing	29.7	TNFRSF25 ICOSLG CD4 CCR6
47	keratoconjunctivitis sicca	29.7	TNFSF13B CD79A CD4 CCR6
48	primary biliary cholangitis	29.6	ICOSLG CD79A CD40LG CD4 CCR6
49	t cell deficiency	29.6	ICOSLG CD4 CD19 CCR6
50	immune deficiency disease	29.6	TNFSF13B TNFRSF13B MBL2 ICOSLG HLA-DQB1 CD79A

Graphical network of the top 20 diseases related to Immunoglobulin Alpha Deficiency:

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Symptoms & Phenotypes for Immunoglobulin Alpha Deficiency

GenomeRNAi Phenotypes related to Immunoglobulin Alpha Deficiency according to GeneCards Suite gene sharing:

²⁶ (show all 13)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00106-A-0	10.02	MBL2
2	Decreased viability	GR00221-A-1	10.02	MSH5
3	Decreased viability	GR00221-A-3	10.02	MSH5
4	Decreased viability	GR00221-A-4	10.02	MSH5
5	Decreased viability	GR00240-S-1	10.02	CD40LG
6	Decreased viability	GR00249-S	10.02	CD19 CD79A HP TNFRSF13B
7	Decreased viability	GR00301-A	10.02	MSH5
8	Decreased viability	GR00342-S-2	10.02	CD4
9	Decreased viability	GR00381-A-1	10.02	CD19 CD79A HLA-DQB1 TNFRSF13B
10	Decreased viability	GR00381-A-3	10.02	CD79A HLA-DQB1
11	Decreased viability	GR00386-A-1	10.02	CD79A ICOSLG
12	Decreased viability	GR00402-S-2	10.02	HLA-DQB1 PIGR TNFRSF25 TNFSF13B
13	Reduced mammosphere formation	GR00396-S	9.17	C4A CCR6 CD79A MSH5 TNFRSF13B TNFRSF13C

MGI Mouse Phenotypes related to Immunoglobulin Alpha Deficiency:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.28	AICDA CCR6 CD19 CD4 CD40LG CD79A
2	homeostasis/metabolism	MP:0005376	10.13	AICDA CCR6 CD19 CD4 CD40LG CD79A
3	cellular	MP:0005384	10.11	AICDA CD19 CD4 CD40LG CD79A HLA-DQB1
4	immune system	MP:0005387	10.11	AICDA CCR6 CD19 CD4 CD40LG CD79A
5	neoplasm	MP:0002006	9.5	AICDA CD19 CD79A HP MSH5 TGM2
6	renal/urinary system	MP:0005367	9.23	CD19 CD40LG CD79A HLA-DQB1 HP MBL2

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Drugs & Therapeutics for Immunoglobulin Alpha Deficiency

Drugs for Immunoglobulin Alpha Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Immunologic Factors		Phase 2
2	Immunoglobulin G		Phase 2
3	Anti-Infective Agents		Phase 2
4	Immunoglobulins		Phase 2
5	Anti-Bacterial Agents		Phase 2
6	Vaccines		Phase 2
7	Heptavalent Pneumococcal Conjugate Vaccine		Phase 2
8	Immunoglobulins, Intravenous		Phase 2
9	Antibodies		Phase 2
10	Immunoglobulin A		Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency	Completed	NCT01847781	Phase 2
2	A Phase I Dose Escalation Study of B-Lymphocyte Stimulator (BLyS) Administered Subcutaneously in Patients With Selective IgA Deficiency	Completed	NCT00024934	Phase 1	B-Lymphocyte Stimulator (BLyS)

Search NIH Clinical Center for Immunoglobulin Alpha Deficiency

Cochrane evidence based reviews: iga deficiency

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Genetic Tests for Immunoglobulin Alpha Deficiency

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Anatomical Context for Immunoglobulin Alpha Deficiency

MalaCards organs/tissues related to Immunoglobulin Alpha Deficiency:

⁴⁰

Liver, Bone, T Cells, Bone Marrow, B Cells, Thyroid, Neutrophil

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Publications for Immunoglobulin Alpha Deficiency

Articles related to Immunoglobulin Alpha Deficiency:

(show top 50) (show all 1810)

#	Title	Authors	PMID	Year
1	Selective IgA deficiency. ⁶¹ ⁵⁴	Yel L	20101521	2010
2	The outcome of patients with unclassified hypogammaglobulinemia in early childhood. ⁶¹ ⁵⁴	Kutukculer N...Gulez N	19196447	2009
3	B-lymphocyte stimulator and a proliferation-inducing ligand serum levels in IgA-deficient patients with and without celiac disease. ⁵⁴ ⁶¹	Fabris M...Tonutti E	19758161	2009
4	Adenosine deaminase in patients with primary immunodeficiency syndromes: the analysis of serum ADA1 and ADA2 activities. ⁶¹ ⁵⁴	Poursharifi P...Shams S	19026999	2009
5	Clinical presentation of celiac disease and the diagnostic accuracy of serologic markers in children. ⁵⁴ ⁶¹	Lurz E...Schibli S	18923841	2009
6	[IgA subclass and IgA deficiency]. ⁶¹ ⁵⁴	Kaneko H...Kondo N	19564710	2009
7	Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. ⁵⁴ ⁶¹	Park K...Kim JC	19399287	2009
8	Various expression patterns of alpha1 and alpha2 genes in IgA deficiency. ⁵⁴ ⁶¹	Suzuki H...Kondo N	19153537	2009
9	The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency. ⁵⁴ ⁶¹	Haimila K...Saavalainen P	19020530	2009
10	Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. ⁵⁴ ⁶¹	Basso D...Plebani M	18988751	2009
11	An evaluation of the DiaMed assays for immunoglobulin A antibodies (anti-IgA) and IgA deficiency. ⁶¹ ⁵⁴	Brown R...Popp H	18657081	2008
12	Selective immunoglobulin A deficiency in Iranian blood donors: prevalence, laboratory and clinical findings. ⁵⁴ ⁶¹	Saghafi S...Moin M	18780950	2008
13	Celiac disease in patients with type-1 diabetes mellitus screened by tissue transglutaminase antibodies in northwest of Iran. ⁵⁴ ⁶¹	Sharifi N...Bahrami A	19902043	2008
14	Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. ⁵⁴ ⁶¹	Jacob CM...Monteiro RC	18202833	2008
15	Alterations in humoral immunity in relatives of patients with common variable immunodeficiency. ⁵⁴ ⁶¹	Aghamohammadi A...Pourpak Z	18714534	2008
16	Association of HLA-08:DRB103 with immunoglobulin A-deficiency. ⁵⁴ ⁶¹	Czyzewska-Buczynska A...Jankowski A	18057683	2007
17	Mapping susceptibility gene locus for IgA deficiency at del(18)(q22.3-q23); report of familial cryptic chromosome t(18q; 10p) translocations. ⁶¹ ⁵⁴	Dostal A...Tienari P	17504501	2007
18	Increases in serum immunoglobulins to age-related normal levels in children with IgA and/or IgG subclass deficiency. ⁶¹ ⁵⁴	Kutukculer N...Aksu G	17338791	2007
19	The clinical significance of immunoglobulin A deficiency. ⁵⁴ ⁶¹	Latiff AH...Kerr MA	17362578	2007
20	Population screening for coeliac disease in a low prevalence area in Italy. ⁶¹ ⁵⁴	Menardo G...Pesce G	17101572	2006
21	TACI mutation in common variable immunodeficiency and IgA deficiency. ⁵⁴ ⁶¹	Rachid R...Bonilla FA	16899196	2006
22	Do we need to measure total serum IgA to exclude IgA deficiency in coeliac disease? ⁵⁴ ⁶¹	Sinclair D...Kerr D	16489174	2006
23	Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family study. ⁵⁴ ⁶¹	Ortiz J...Martinez A	16803619	2006
24	Dermatitis herpetiformis and partial IgA deficiency. ⁵⁴ ⁶¹	Samolitis NJ...Zone JJ	16631941	2006
25	Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L. ⁶¹ ⁵⁴	Husain Z...Alper CA	16758339	2006
26	Immunoglobulins and inflammatory cytokines in nasal secretions in humoral immunodeficiencies. ⁶¹ ⁵⁴	Rose MA...Zielen S	16467712	2006
27	Celiac disease in North Italian patients with autoimmune Addison's disease. ⁶¹ ⁵⁴	Betterle C...Albergoni M	16452541	2006
28	Rheumatoid arthritis in a patient with common variable immunodeficiency: difficulty in diagnosis and therapy. ⁶¹ ⁵⁴	Swierkot J...Szechinski J	15940551	2006
29	An unusual case of hemoperitoneum owing to acute splenic torsion in a child with immunoglobulin deficiency. ⁵⁴ ⁶¹	Lopez-Tomassetti Fernandez EM...Carrillo Pallares A	16534164	2006
30	The prevalence of humoral immunodeficiency in refractory rhinosinusitis: a retrospective analysis. ⁶¹ ⁵⁴	Vanlerberghe L...Jorissen M	17256402	2006
31	TACI is mutant in common variable immunodeficiency and IgA deficiency. ⁶¹ ⁵⁴	Castigli E...Geha RS	16007086	2005
32	Frequent false positive beta human chorionic gonadotropin tests in immunoglobulin A deficiency. ⁶¹ ⁵⁴	Knight AK...Cunningham-Rundles C	15996198	2005
33	IgA deficiency: clinical correlates with IgG subclass and mannan-binding lectin deficiencies. ⁵⁴ ⁶¹	Santaella ML...Disdier OM	16116926	2005
34	IgA deficiency and membranous glomerulonephritis presenting as nephrotic syndrome. ⁵⁴ ⁶¹	Kawasaki Y...Suzuki H	15711951	2005
35	IgA and/or IgG subclass deficiency in children with recurrent respiratory infections and its relationship with chronic pulmonary damage. ⁶¹ ⁵⁴	Ozkan H...Gunvar T	15864886	2005
36	Diagnosing celiac disease: a comparison of human tissue transglutaminase antibodies with antigliadin and antiendomysium antibodies. ⁵⁴ ⁶¹	Baudon JJ...Mougenot JF	15184223	2004
37	Molecular analysis of B-cell differentiation in selective or partial IgA deficiency. ⁶¹ ⁵⁴	Asano T...Kondo N	15086392	2004
38	Gender, age and seasonal effects on IgA deficiency: a study of 7293 Caucasians. ⁵⁴ ⁶¹	Weber-Mzell D...Deutsch J	15025682	2004
39	Oral manifestations in selective IgA deficiency. ⁵⁴ ⁶¹	Nikfarjam J...Aghamohammadi A	16451448	2004
40	Immunoglobulin subclasses and HLA alleles in immunoglobulin A deficiency. ⁵⁴ ⁶¹	Kilic SS...Goral G	12841399	2003
41	The syndrome of chronic mucocutaneous candidiasis with selective antibody deficiency. ⁶¹ ⁵⁴	Kalfa VC...Stiehm ER	12602677	2003
42	IgA deficiency with membranous glomerulonephritis: a case report and review. ⁵⁴ ⁶¹	Huang JB...Lin CC	12649548	2003
43	Evaluation of the relevance of humoral immunodeficiencies in a pediatric population affected by recurrent infections. ⁶¹ ⁵⁴	Finocchi A...Moschese V	12485321	2002
44	Celiac disease and immunoglobulin a deficiency: how effective are the serological methods of diagnosis? ⁵⁴ ⁶¹	Kumar V...Jablonska S	12414763	2002
45	MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes. ⁵⁴ ⁶¹	De la Concha EG...Fontan G	12370403	2002
46	Immunoglobulin G autoantibodies against tissue-transglutaminase. A sensitive, cost-effective assay for the screening of celiac disease. ⁶¹ ⁵⁴	Bilbao JR...Castano L	12482193	2002
47	Central MHC genes affect IgA levels in the human: reciprocal effects in IgA deficiency and IgA nephropathy. ⁵⁴ ⁶¹	Matthews VB...Price P	11975987	2002
48	Analysis of Ig subclass deficiency: First reported case of IgG2, IgG4, and IgA deficiency caused by deletion of C alpha 1, psi C gamma, C gamma 2, C gamma 4, and C epsilon in a Mongoloid patient. ⁵⁴ ⁶¹	Terada T...Kondo N	11590388	2001
49	Physiology of IgA and IgA deficiency. ⁵⁴ ⁶¹	Cunningham-Rundles C	11720003	2001
50	[IgA deficiency]. ⁶¹ ⁵⁴	Quartier P	11446186	2001

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Genes for Immunoglobulin Alpha Deficiency

Genes related to Immunoglobulin Alpha Deficiency (0 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TNFRSF13B	TNF Receptor Superfamily Member 13B	Protein Coding	16.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	16007086 16899196
2	CD79A	CD79a Molecule	Protein Coding	15.73	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17362578 2093881 16631941 (more) 20101521 10757854 10361242 8338210 7614739 10702491 1817567 2130777 18657081 12649548 9175025 16452541 7874319 2377448 12841399 15086392 7892814 9606003 16489174 1735187 10931389 8385798 7593466 18714534 17338791 1356100 16803619 7998658 19153537 15864886 11446186 1496540 7686742 18988751 7645563 1509524 11720003 2206270 1641842 7583926 10090895 8885159 18057683 15996198 8634934 8195313 8301144 1728983 17504501 17101572 15025682 12370403 11975987 10370371 8039782 19026999 18923841 17256402 16534164 11141427 8885812 1728531 2071295 2402790 8516791 1885069 11590388 7527197 8222325 19564710 15711951 1891793 12602677 9222726 7546158 16451448 12414763 9338552 1481472 2094745 19902043 19020530 19399287 18780950 18202833 8271124 7874323 10975212 1493932 1529270 1625088 19196447 19758161 15184223 12482193 11044476
3	CD40LG	CD40 Ligand	Protein Coding	14.79	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1496540 8385798 15940551 (more) 2146585 10361242 19196447 1502496 18714534 16467712 12485321 8398198 1728983 16758339 8711159 8222325 2375827
4	C4A	Complement C4A (Rodgers Blood Group)	Protein Coding	12.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1817567
5	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	11.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1438261 1520483
6	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.23	DISEASES inferred ¹⁵ ¹⁵
7	MBL2	Mannose Binding Lectin 2	Protein Coding	9	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	10361242 7707811 16116926
8	TGM2	Transglutaminase 2	Protein Coding	8.25	DISEASES inferred ¹⁵
9	HP	Haptoglobin	Protein Coding	8.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8711159
10	TOR1A	Torsin Family 1 Member A	Protein Coding	8.04	DISEASES inferred ¹⁵
11	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.96	DISEASES inferred ¹⁵ ¹⁵
12	JCHAIN	Joining Chain Of Multimeric IgA And IgM	Protein Coding	7.25	DISEASES inferred ¹⁵
13	PIGR	Polymeric Immunoglobulin Receptor	Protein Coding	7.21	DISEASES inferred ¹⁵
14	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	7.05	DISEASES inferred ¹⁵
15	TNFRSF13C	TNF Receptor Superfamily Member 13C	Protein Coding	6.68	DISEASES inferred ¹⁵
16	MSH5	MutS Homolog 5	Protein Coding	6.6	DISEASES inferred ¹⁵
17	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	6.59	DISEASES inferred ¹⁵
18	CD4	CD4 Molecule	Protein Coding	6.56	DISEASES inferred ¹⁵
19	CD19	CD19 Molecule	Protein Coding	6.55	DISEASES inferred ¹⁵
20	AICDA	Activation Induced Cytidine Deaminase	Protein Coding	6.52	DISEASES inferred ¹⁵
21	CD27	CD27 Molecule	Protein Coding	6.45	DISEASES inferred ¹⁵
22	CD8A	CD8a Molecule	Protein Coding	6.29	DISEASES inferred ¹⁵
23	FCAR	Fc Fragment Of IgA Receptor	Protein Coding	6.17	DISEASES inferred ¹⁵
24	CD40	CD40 Molecule	Protein Coding	6.14	DISEASES inferred ¹⁵

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Variations for Immunoglobulin Alpha Deficiency

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Expression for Immunoglobulin Alpha Deficiency

Search GEO for disease gene expression data for Immunoglobulin Alpha Deficiency.

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Pathways for Immunoglobulin Alpha Deficiency

Pathways related to Immunoglobulin Alpha Deficiency according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.72	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B PIGR MBL2
2	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.24	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B CD40LG CD4
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.18	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B HLA-DQB1 CD40LG
4	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.11	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B CD40LG CD4
5	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.43	ICOSLG HLA-DQB1 CD79A CD40LG CD4
6	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.4	TNFSF13B TNFRSF13C TNFRSF13B PIGR ICOSLG HLA-DQB1
7	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.36	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B CD40LG
8	NF-kappaB Signaling ⁴	12.36	TNFSF13B TNFRSF25 CD79A CD40LG CD19 AICDA
9	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.22	ICOSLG HLA-DQB1 CD40LG CD4
10	Cell adhesion molecules ³⁶	11.93	ICOSLG HLA-DQB1 CD40LG CD4
11	NF-kappa B signaling pathway ³⁶	11.77	TNFSF13B TNFRSF13C CD40LG
12	Hematopoietic cell lineage ³⁶	11.74	HLA-DQB1 CD4 CD19
13	Staphylococcus aureus infection ³⁶	11.72	MBL2 HLA-DQB1 C4A
14	TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.63	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B CD40LG
15	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²³	11.57	TNFSF13B TNFRSF25 TNFRSF13B CD40LG
16	IL4-mediated signaling events ¹	11.49	PIGR CD40LG AICDA
17	IgA-Producing B Cells in the Intestine ⁶⁴	11.45	TNFSF13B TNFRSF13C TNFRSF13B ICOSLG CD40LG CCR6
18	Primary immunodeficiency ³⁶	10.75	TNFRSF13C TNFRSF13B CD79A CD40LG CD4 CD19

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GO Terms for Immunoglobulin Alpha Deficiency

Cellular components related to Immunoglobulin Alpha Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.8	TNFRSF25 TNFRSF13B PIGR CD40LG CD4 CD19
2	plasma membrane	GO:0005886	9.8	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B TGM2 PIGR
3	external side of plasma membrane	GO:0009897	9.17	TNFRSF13C ICOSLG CD79A CD40LG CD4 CD19
4	secretory IgA immunoglobulin complex	GO:0071751	9.16	PIGR JCHAIN

Biological processes related to Immunoglobulin Alpha Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.85	TNFSF13B JCHAIN HLA-DQB1 CD40LG CD4 CCR6
2	positive regulation of T cell proliferation	GO:0042102	9.62	TNFSF13B TNFRSF13C CD40LG CD4
3	B cell differentiation	GO:0030183	9.61	CD79A CD40LG AICDA
4	T cell costimulation	GO:0031295	9.56	TNFSF13B TNFRSF13C ICOSLG CD40LG
5	adaptive immune response	GO:0002250	9.56	TNFRSF13C TNFRSF13B JCHAIN ICOSLG HLA-DQB1 CD79A
6	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.55	TNFSF13B TNFRSF25 TNFRSF13C TNFRSF13B CD40LG
7	B cell costimulation	GO:0031296	9.4	TNFSF13B TNFRSF13C
8	immune system process	GO:0002376	9.36	TNFSF13B TNFRSF13C TNFRSF13B MBL2 ICOSLG HP

Molecular functions related to Immunoglobulin Alpha Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor activity	GO:0038023	9.02	TNFRSF25 TNFRSF13C TNFRSF13B CD4 CCR6

Sources

Sources for Immunoglobulin Alpha Deficiency

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia