IGES
MCID: IMM162
MIFTS: 29

Immunoglobulin E Concentration, Serum (IGES)

Categories: Immune diseases

Aliases & Classifications for Immunoglobulin E Concentration, Serum

MalaCards integrated aliases for Immunoglobulin E Concentration, Serum:

Name: Immunoglobulin E Concentration, Serum 57 13 72
Allergy and Asthma Susceptibility 57
Iges 57

Classifications:



External Ids:

OMIM 57 147061
UMLS 72 C1840252

Summaries for Immunoglobulin E Concentration, Serum

MalaCards based summary : Immunoglobulin E Concentration, Serum, also known as allergy and asthma susceptibility, is related to hyper-ige recurrent infection syndrome 1, autosomal dominant and hyper ige syndrome. An important gene associated with Immunoglobulin E Concentration, Serum is IGES (Immunoglobulin E Concentration, Serum). The drugs Immunologic Factors and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lung.

More information from OMIM: 147061

Related Diseases for Immunoglobulin E Concentration, Serum

Diseases related to Immunoglobulin E Concentration, Serum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1183)
# Related Disease Score Top Affiliating Genes
1 hyper-ige recurrent infection syndrome 1, autosomal dominant 12.9
2 hyper ige syndrome 12.8
3 hyper-ige recurrent infection syndrome 2, autosomal recessive 12.7
4 congenital disorder of glycosylation, type ig 12.7
5 hyper-ige recurrent infection syndrome 3, autosomal recessive 12.6
6 hyper-ige recurrent infection syndrome 4, autosomal recessive 12.5
7 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige 12.5
8 ige responsiveness, atopic 12.5
9 hyper ige recurrent infection syndrome 1 12.5
10 amelogenesis imperfecta, type ig 12.4
11 selective ige deficiency disease 12.4
12 obsolete: autosomal recessive hyper-ige syndrome 12.3
13 asthma 12.3
14 usher syndrome, type ig 12.2
15 allergic rhinitis 12.2
16 immunodeficiency 35 12.2
17 amelogenesis imperfecta hypoplastic type, ig 12.1
18 acquired monoclonal ig light chain-associated fanconi syndrome 12.1
19 epilepsy, idiopathic generalized 12.1
20 netherton syndrome 12.1
21 immunodeficiency 23 12.0
22 dock8 immunodeficiency syndrome 12.0
23 megaloblastic anemia 1 11.9
24 hypereosinophilic syndrome 11.9
25 dermatitis, atopic 11.9
26 allergic hypersensitivity disease 11.9
27 immunodeficiency 11b with atopic dermatitis 11.8
28 common variable immunodeficiency 11.8
29 iminoglycinuria 11.8
30 agammaglobulinemia 11.8
31 immunodeficiency with hyper-igm, type 1 11.7
32 allergic asthma 11.6
33 immunodeficiency with hyper-igm, type 2 11.6
34 c3 glomerulopathy 11.6
35 agammaglobulinemia, x-linked 11.5
36 asthma-related traits 1 11.5
37 asthma-related traits 2 11.5
38 omenn syndrome 11.5
39 immunodeficiency with hyper-igm, type 4 11.5
40 asthma-related traits 4 11.4
41 nephrotic syndrome, type 7 11.4
42 dermatitis herpetiformis 11.4
43 anemia, autoimmune hemolytic 11.4
44 immunoglobulin a deficiency 1 11.4
45 lymphoplasmacytic lymphoma 11.4
46 amyloidosis, hereditary, transthyretin-related 11.4
47 masa syndrome 11.4
48 immunodeficiency with hyper-igm, type 3 11.4
49 immunodeficiency with hyper-igm, type 5 11.3
50 hyperglycinuria 11.2

Graphical network of the top 20 diseases related to Immunoglobulin E Concentration, Serum:



Diseases related to Immunoglobulin E Concentration, Serum

Symptoms & Phenotypes for Immunoglobulin E Concentration, Serum

Clinical features from OMIM:

147061

Drugs & Therapeutics for Immunoglobulin E Concentration, Serum

Drugs for Immunoglobulin E Concentration, Serum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2
Omalizumab Approved, Investigational Phase 1 242138-07-4
3
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
4
Racepinephrine Approved Phase 1 329-65-7 838
5 Sulfalene Phase 1
6 Bifidobacterium Phase 1
7 Antibodies Phase 1
8 Immunoglobulins Phase 1
9 Anti-Allergic Agents Phase 1
10 Respiratory System Agents Phase 1
11 Antibodies, Monoclonal Phase 1
12 Anti-Asthmatic Agents Phase 1
13 Epinephryl borate Phase 1
14
arachidonic acid Experimental 506-32-1 444899
15 Omega 3 Fatty Acid

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Birch Pollen Immunotherapy in Local Allergic Rhinitis Completed NCT03157505 Phase 3 Purethal Birch immunotherapy
2 Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis Recruiting NCT03835767 Phase 2
3 A Parallel-group, Randomized, Placebo-controlled Ascending Dose Phase I Study Protocol for Dietary Supplementation With Bifidobacterium Longum Subsp. Infantis (B. Infantis) in Healthy Breastfed Infants Unknown status NCT02286999 Phase 1 B. infantis;Placebo
4 A Phase 1b, Randomized, Double-Blind, Placebo Controlled Study With an Open Label Extension to Evaluate the Safety and Tolerability of Omalizumab, A Humanized IgG1 Monoclonal Antibody in Patients With Lupus (STOP LUPUS) Completed NCT01716312 Phase 1 Omalizumab
5 Phase 1 Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS Completed NCT00546689
6 The Effects of Extended Duration of Long-Chain Polyunsaturated Fatty Acid (LCP)-Supplementation on Neurological and Immunological Development in Toddlers Completed NCT00982462
7 Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy Recruiting NCT03352193
8 Impact of Different Dietary IgGs on the Pathogenesis of Inflammatory Bowel Disease Not yet recruiting NCT03885479

Search NIH Clinical Center for Immunoglobulin E Concentration, Serum

Genetic Tests for Immunoglobulin E Concentration, Serum

Anatomical Context for Immunoglobulin E Concentration, Serum

MalaCards organs/tissues related to Immunoglobulin E Concentration, Serum:

41
Testes, Skin, Lung, B Cells, Cortex, Liver, Whole Blood

Publications for Immunoglobulin E Concentration, Serum

Articles related to Immunoglobulin E Concentration, Serum:

(show top 50) (show all 500)
# Title Authors PMID Year
1
An epigenome-wide association study of total serum immunoglobulin E concentration. 8
25707804 2015
2
Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. 8
11378822 2001
3
Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families. 8
11093275 2000
4
Major genes regulating total serum immunoglobulin E levels in families with asthma. 8
11023809 2000
5
Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. 8
9328470 1997
6
Serum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat. 8
8808287 1996
7
Evidence for two unlinked loci regulating total serum IgE levels. 8
7668269 1995
8
Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. 8
7835897 1994
9
Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. 8
8178175 1994
10
HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. 8
6770269 1980
11
Social runaway: Fisherian elaboration (or reduction) of socially selected traits via indirect genetic effects. 38
31273777 2019
12
Identification of pyruvate kinase 2 as a possible crab allergen and analysis of allergenic proteins in crabs consumed in Taiwan. 38
30955631 2019
13
Antibody Cross-Reactivity between Proteins of Chia Seed ( Salvia hispanica L.) and Other Food Allergens. 38
31117490 2019
14
Re-exploring immune-related side effects of docetaxel in an observational study: Blood hypereosinophilia. 38
30854809 2019
15
Enhanced sensitivity of capture IgE‑ELISA based on a recombinant Der f 1/2 fusion protein for the detection of IgE antibodies targeting house dust mite allergens. 38
30896856 2019
16
Evaluation of AdvanSure AlloScreen Max Panel With 92 Different Allergens for Detecting Allergen-Specific IgE. 38
30984971 2019
17
Serological analysis of sensitization in allergic bronchopulmonary aspergillosis: a study on allergen components and interspecies relationships. 38
30943819 2019
18
Direct and indirect genetic effects on reproductive investment in a grasshopper. 38
30693584 2019
19
IgE testing can predict food allergy status in patients with moderate to severe atopic dermatitis. 38
30639434 2019
20
The role of indirect genetic effects in the evolution of interacting reproductive behaviors in the burying beetle, Nicrophorus vespilloides. 38
30805136 2019
21
Indirect genetic effect model using feeding behaviour traits to define the degree of interaction between mates: an implementation in pigs growth rate. 38
29871710 2019
22
Anaphylaxis to Beluga caviar. 38
30660175 2019
23
Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study. 38
30643099 2019
24
Generalized epilepsies. 38
31307608 2019
25
I Smell a Mouse: Indirect Genetic Effects on Voluntary Wheel-Running Distance, Duration and Speed. 38
30324246 2019
26
Cortical excitability affects mood state in patients with idiopathic generalized epilepsies (IGEs). 38
30517908 2019
27
Is atopic sensitization associated with indicators of early vascular ageing in adolescents? 38
31415591 2019
28
Under-diagnosis of atopic dermatitis in Puerto Rican children. 38
30937128 2019
29
Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals. 38
30368492 2019
30
Evaluation of a Standardized Bakery Product (SUTMEK) as a Potential Tool for Baked-Milk Tolerance and Immunotherapy Research Studies. 38
30404088 2019
31
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis. 38
30194992 2019
32
Cortical excitability and seizure control influence attention performance in patients with idiopathic generalized epilepsies (IGEs). 38
30415135 2018
33
Modelling the co-evolution of indirect genetic effects and inherited variability. 38
29588510 2018
34
Increased developmental density decreases the magnitude of indirect genetic effects expressed during agonistic interactions in an insect. 38
30221347 2018
35
Machine learning to identify pairwise interactions between specific IgE antibodies and their association with asthma: A cross-sectional analysis within a population-based birth cohort. 38
30422985 2018
36
Epitope Mapping by HDX-MS Elucidates the Surface Coverage of Antigens Associated with High Blocking Efficiency of Antibodies to Birch Pollen Allergen. 38
30170487 2018
37
Reduction of greenhouse gases (GHGs) and short-lived climate pollutants (SLCPs) from municipal solid waste management (MSWM) in the Philippines: Rapid review and assessment. 38
30455021 2018
38
Association between dengue severity and plasma levels of dengue-specific IgE and chymase. 38
29728909 2018
39
Is food protein induced enterocolitis syndrome only a non IgE-mediated food allergy? 38
29472022 2018
40
Identification of the 7S and 11S globulins as percutaneously sensitizing soybean allergens as demonstrated through epidermal application of crude soybean extract. 38
29629624 2018
41
Identification of pyruvate kinase as a novel allergen in whiteleg shrimp (Litopenaeus vannamei) by specific-IgE present in patients with shrimp allergy. 38
29655746 2018
42
Data on various allergen specific IgEs and prospective treatments on food-dependent exercise-induced anaphylaxis. 38
29904693 2018
43
The causes and evolutionary consequences of variation in female mate choice in insects: the effects of individual state, genotypes and environments. 38
30025624 2018
44
Characterization of epitope specificities of reference antibodies used for the quantification of the birch pollen allergen Bet v 1. 38
29171882 2018
45
Changes in L4/5 Intervertebral Foramen Bony Morphology with Age. 38
29769656 2018
46
RSV-hRV co-infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis. 38
29380391 2018
47
More than a decade follow-up in patients with severe or difficult-to-treat asthma: The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) II. 38
28797732 2018
48
GxG epistasis in growth and condition and the maintenance of genetic polymorphism in Gambusia holbrooki. 38
29604041 2018
49
De novo late-onset absence status epilepticus or late-onset idiopathic generalized epilepsy? A case report and systematic review of the literature. 38
29620008 2018
50
Group-level competition influences urinary steroid hormones among wild red-tailed monkeys, indicating energetic costs. 38
29635811 2018

Variations for Immunoglobulin E Concentration, Serum

Expression for Immunoglobulin E Concentration, Serum

Search GEO for disease gene expression data for Immunoglobulin E Concentration, Serum.

Pathways for Immunoglobulin E Concentration, Serum

GO Terms for Immunoglobulin E Concentration, Serum

Sources for Immunoglobulin E Concentration, Serum

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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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