IGES
MCID: IMM162
MIFTS: 28

Immunoglobulin E Concentration, Serum (IGES)

Categories: Immune diseases

Aliases & Classifications for Immunoglobulin E Concentration, Serum

MalaCards integrated aliases for Immunoglobulin E Concentration, Serum:

Name: Immunoglobulin E Concentration, Serum 56 13 71
Allergy and Asthma Susceptibility 56
Iges 56

Classifications:



External Ids:

OMIM 56 147061
UMLS 71 C1840252

Summaries for Immunoglobulin E Concentration, Serum

MalaCards based summary : Immunoglobulin E Concentration, Serum, also known as allergy and asthma susceptibility, is related to hyper ige syndrome and hyper-ige recurrent infection syndrome 1, autosomal dominant. An important gene associated with Immunoglobulin E Concentration, Serum is IGES (Immunoglobulin E Concentration, Serum). The drugs Epinephrine and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and lung.

More information from OMIM: 147061

Related Diseases for Immunoglobulin E Concentration, Serum

Diseases related to Immunoglobulin E Concentration, Serum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1185)
# Related Disease Score Top Affiliating Genes
1 hyper ige syndrome 12.9
2 hyper-ige recurrent infection syndrome 1, autosomal dominant 12.9
3 hyper-ige recurrent infection syndrome 2, autosomal recessive 12.7
4 ige responsiveness, atopic 12.7
5 congenital disorder of glycosylation, type ig 12.7
6 hyper-ige recurrent infection syndrome 3, autosomal recessive 12.6
7 hyper-ige recurrent infection syndrome 4, autosomal recessive 12.6
8 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige 12.5
9 hyper ige recurrent infection syndrome 1 12.5
10 amelogenesis imperfecta, type ig 12.4
11 selective ige deficiency disease 12.4
12 hyper ige recurrent infection syndrome 2 12.3
13 hyper ige recurrent infection syndrome 3 12.3
14 hyper ige recurrent infection syndrome 4 12.3
15 obsolete: autosomal recessive hyper-ige syndrome 12.3
16 usher syndrome, type ig 12.2
17 asthma 12.2
18 immunodeficiency 35 12.2
19 allergic rhinitis 12.1
20 amelogenesis imperfecta hypoplastic type, ig 12.1
21 acquired monoclonal ig light chain-associated fanconi syndrome 12.1
22 epilepsy, idiopathic generalized 12.1
23 netherton syndrome 12.1
24 immunodeficiency 23 12.1
25 dock8 immunodeficiency syndrome 12.0
26 megaloblastic anemia 1 11.9
27 immunodeficiency 11b with atopic dermatitis 11.8
28 hypereosinophilic syndrome 11.8
29 dermatitis, atopic 11.8
30 common variable immunodeficiency 11.8
31 allergic hypersensitivity disease 11.8
32 food allergy 11.8
33 agammaglobulinemia 11.8
34 iminoglycinuria 11.8
35 immunodeficiency with hyper-igm, type 1 11.7
36 milk allergy 11.7
37 pgm3-congenital disorder of glycosylation 11.7
38 allergic bronchopulmonary aspergillosis 11.7
39 vernal keratoconjunctivitis 11.7
40 allergic asthma 11.6
41 immunodeficiency with hyper-igm, type 2 11.6
42 c3 glomerulopathy 11.6
43 latex allergy 11.6
44 agammaglobulinemia, x-linked 11.5
45 asthma-related traits 1 11.5
46 asthma-related traits 2 11.5
47 omenn syndrome 11.5
48 immunodeficiency with hyper-igm, type 4 11.5
49 nut allergy 11.5
50 beta-lactam allergy 11.5

Graphical network of the top 20 diseases related to Immunoglobulin E Concentration, Serum:



Diseases related to Immunoglobulin E Concentration, Serum

Symptoms & Phenotypes for Immunoglobulin E Concentration, Serum

Clinical features from OMIM:

147061

Drugs & Therapeutics for Immunoglobulin E Concentration, Serum

Drugs for Immunoglobulin E Concentration, Serum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
2
Omalizumab Approved, Investigational Phase 1 242138-07-4
3
Racepinephrine Approved Phase 1 329-65-7 838
4 Immunoglobulins Phase 1
5 Antibodies Phase 1
6 Antibodies, Monoclonal Phase 1
7 Epinephryl borate Phase 1
8 Respiratory System Agents Phase 1
9 Anti-Asthmatic Agents Phase 1
10 Anti-Allergic Agents Phase 1
11
arachidonic acid Experimental 506-32-1 444899
12 Omega 3 Fatty Acid
13 Immunologic Factors
14 Immunoglobulin G

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Birch Pollen Immunotherapy in Local Allergic Rhinitis Completed NCT03157505 Phase 3 Purethal Birch immunotherapy
2 Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis Recruiting NCT03835767 Phase 2
3 A Phase 1b, Randomized, Double-Blind, Placebo Controlled Study With an Open Label Extension to Evaluate the Safety and Tolerability of Omalizumab, A Humanized IgG1 Monoclonal Antibody in Patients With Lupus (STOP LUPUS) Completed NCT01716312 Phase 1 Omalizumab
4 A Parallel-group, Randomized, Placebo-controlled Ascending Dose Phase I Study Protocol for Dietary Supplementation With Bifidobacterium Longum Subsp. Infantis (B. Infantis) in Healthy Breastfed Infants Withdrawn NCT02286999 Phase 1 B. infantis;Placebo
5 Phase 1 Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS Completed NCT00546689
6 The Effects of Extended Duration of Long-Chain Polyunsaturated Fatty Acid (LCP)-Supplementation on Neurological and Immunological Development in Toddlers Completed NCT00982462
7 Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy Recruiting NCT03352193
8 Impact of Different Dietary IgGs on the Pathogenesis of Inflammatory Bowel Disease Not yet recruiting NCT03885479

Search NIH Clinical Center for Immunoglobulin E Concentration, Serum

Genetic Tests for Immunoglobulin E Concentration, Serum

Anatomical Context for Immunoglobulin E Concentration, Serum

MalaCards organs/tissues related to Immunoglobulin E Concentration, Serum:

40
T Cells, Skin, Lung, B Cells, Liver, Kidney, Bone

Publications for Immunoglobulin E Concentration, Serum

Articles related to Immunoglobulin E Concentration, Serum:

(show top 50) (show all 515)
# Title Authors PMID Year
1
An epigenome-wide association study of total serum immunoglobulin E concentration. 56
25707804 2015
2
Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. 56
11378822 2001
3
Major genes regulating total serum immunoglobulin E levels in families with asthma. 56
11023809 2000
4
Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families. 56
11093275 2000
5
Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. 56
9328470 1997
6
Serum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat. 56
8808287 1996
7
Evidence for two unlinked loci regulating total serum IgE levels. 56
7668269 1995
8
Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. 56
7835897 1994
9
Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. 56
8178175 1994
10
HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. 56
6770269 1980
11
Antiviral activity of iridoid glycosides extracted from Fructus Gardeniae against influenza A virus by PACT-dependent suppression of viral RNA replication. 61
32024921 2020
12
Tonic-clonic seizures in idiopathic generalized epilepsies: prevalence, risk factors, and outcome. 61
32030724 2020
13
An evolutionary switch from sibling rivalry to sibling cooperation, caused by a sustained loss of parental care. 61
31964847 2020
14
Indirect genetic effects on the relationships between production and feeding behaviour traits in growing Duroc pigs. 61
31571565 2020
15
Exercise-induced allergic reactions on desensitization to wheat after rush oral immunotherapy. 61
31953936 2020
16
Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood. 61
31601504 2020
17
Staphylococcus aureus and its IgE-inducing Enterotoxins in Asthma: Current Knowledge. 61
31980492 2020
18
Third-party verification of total and specific immunoglobulin E on analyzer Immulite® 2000XPi. 61
31606400 2020
19
Local fungus-specific Immunoglobulin E production in chronic rhinosinusitis with nasal polyps. 61
31904030 2020
20
Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis. 61
31622668 2020
21
Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study. 61
30643099 2019
22
Identification of immunodominant IgE epitopes of the major house dust mite allergen Der f 24. 61
31545417 2019
23
Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions. 61
31708436 2019
24
Young children with moderate-to-severe atopic dermatitis can be treated safely and effectively with either topical tacrolimus or mild corticosteroids. 61
31483891 2019
25
Green beards in the light of indirect genetic effects. 61
31534678 2019
26
Identification of pyruvate kinase 2 as a possible crab allergen and analysis of allergenic proteins in crabs consumed in Taiwan. 61
30955631 2019
27
Social runaway: Fisherian elaboration (or reduction) of socially selected traits via indirect genetic effects. 61
31273777 2019
28
Antibody Cross-Reactivity between Proteins of Chia Seed ( Salvia hispanica L.) and Other Food Allergens. 61
31117490 2019
29
Re-exploring immune-related side effects of docetaxel in an observational study: Blood hypereosinophilia. 61
30854809 2019
30
Enhanced sensitivity of capture IgE‑ELISA based on a recombinant Der f 1/2 fusion protein for the detection of IgE antibodies targeting house dust mite allergens. 61
30896856 2019
31
Evaluation of AdvanSure AlloScreen Max Panel With 92 Different Allergens for Detecting Allergen-Specific IgE. 61
30984971 2019
32
Serological analysis of sensitization in allergic bronchopulmonary aspergillosis: a study on allergen components and interspecies relationships. 61
30943819 2019
33
Direct and indirect genetic effects on reproductive investment in a grasshopper. 61
30693584 2019
34
IgE testing can predict food allergy status in patients with moderate to severe atopic dermatitis. 61
30639434 2019
35
The role of indirect genetic effects in the evolution of interacting reproductive behaviors in the burying beetle, Nicrophorus vespilloides. 61
30805136 2019
36
Indirect genetic effect model using feeding behaviour traits to define the degree of interaction between mates: an implementation in pigs growth rate. 61
29871710 2019
37
Anaphylaxis to Beluga caviar. 61
30660175 2019
38
Is atopic sensitization associated with indicators of early vascular ageing in adolescents? 61
31415591 2019
39
Generalized epilepsies. 61
31307608 2019
40
Classification of Wheezing Children in Rural Bangladesh by Intensity of Ascaris Infection, Total and Specific IgE Levels, History of Pneumonia, and Other Risk Factors. 61
31886302 2019
41
I Smell a Mouse: Indirect Genetic Effects on Voluntary Wheel-Running Distance, Duration and Speed. 61
30324246 2019
42
Cortical excitability affects mood state in patients with idiopathic generalized epilepsies (IGEs). 61
30517908 2019
43
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis. 61
30194992 2019
44
Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals. 61
30368492 2019
45
Evaluation of a Standardized Bakery Product (SUTMEK) as a Potential Tool for Baked-Milk Tolerance and Immunotherapy Research Studies. 61
30404088 2019
46
Under-diagnosis of atopic dermatitis in Puerto Rican children. 61
30937128 2019
47
Cortical excitability and seizure control influence attention performance in patients with idiopathic generalized epilepsies (IGEs). 61
30415135 2018
48
Modelling the co-evolution of indirect genetic effects and inherited variability. 61
29588510 2018
49
Increased developmental density decreases the magnitude of indirect genetic effects expressed during agonistic interactions in an insect. 61
30221347 2018
50
Machine learning to identify pairwise interactions between specific IgE antibodies and their association with asthma: A cross-sectional analysis within a population-based birth cohort. 61
30422985 2018

Variations for Immunoglobulin E Concentration, Serum

Expression for Immunoglobulin E Concentration, Serum

Search GEO for disease gene expression data for Immunoglobulin E Concentration, Serum.

Pathways for Immunoglobulin E Concentration, Serum

GO Terms for Immunoglobulin E Concentration, Serum

Sources for Immunoglobulin E Concentration, Serum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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