MCID: IMM044
MIFTS: 33

Immunoglobulin G Deficiency

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Immunoglobulin G Deficiency

MalaCards integrated aliases for Immunoglobulin G Deficiency:

Name: Immunoglobulin G Deficiency 53 73
Igg Deficiency 53 29 55 73
Igg Subclass Deficiency 53 55

Classifications:



External Ids:

UMLS 73 C4076140

Summaries for Immunoglobulin G Deficiency

NIH Rare Diseases : 53 Immunoglobulin G (IgG) deficiency is a condition that involves the immune system and is characterized by a shortage of type G antibodies. There are four different subclasses of IgG: IgG1, IgG2, IgG3, and IgG4. People with IgG deficiency may have a decreased amount of one or more of the IgG subclasses or a shortage of other types of antibodies, which may occur in various conditions including X-linked agammaglobulinemia, common variable immunodeficiency, and hyper-IgM syndrome. Individuals with IgG deficiency may have an increased susceptibility to infection, but the symptoms of this condition are variable and some people never experience any symptoms. Treatment may involve antibiotics and intravenous (IV) immunoglobulin.

MalaCards based summary : Immunoglobulin G Deficiency, also known as igg deficiency, is related to selective igg deficiency disease and immunoglobulin alpha deficiency. An important gene associated with Immunoglobulin G Deficiency is CD79A (CD79a Molecule), and among its related pathways/superpathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and IL4-mediated signaling events. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and spinal cord.

Related Diseases for Immunoglobulin G Deficiency

Diseases related to Immunoglobulin G Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 selective igg deficiency disease 32.2 CD40LG CD79A
2 immunoglobulin alpha deficiency 28.9 CD40LG CD79A MBL2
3 meningitis 28.9 CD40LG MBL2
4 common variable immunodeficiency 28.1 CD40LG CD79A FCGRT MBL2
5 immunoglobulin kappa light chain deficiency 11.5
6 specific antibody deficiency 11.2
7 exercise-induced anaphylaxis 10.4 CD79A IGHE
8 gastrointestinal allergy 10.4 CD79A IGHE
9 epidermolysis bullosa acquisita 10.4 CD79A FCGRT
10 c1q nephropathy 10.3 CD40LG CD79A
11 meningovascular neurosyphilis 10.3 CD40LG CD79A
12 alpha chain disease 10.3 CD40LG CD79A
13 brill-zinsser disease 10.3 CD40LG CD79A
14 exudative glomerulonephritis 10.3 CD40LG CD79A
15 cork-handlers' disease 10.3 CD40LG CD79A
16 salpingo-oophoritis 10.3 CD40LG CD79A
17 early yaws 10.3 CD40LG CD79A
18 ventilation pneumonitis 10.3 CD40LG CD79A
19 chronic interstitial cystitis 10.3 CD40LG CD79A
20 axillary adenitis 10.3 CD40LG CD79A
21 cryofibrinogenemia 10.3 CD40LG CD79A
22 trichostrongyloidiasis 10.3 CD40LG CD79A
23 subacute bacterial endocarditis 10.3 CD40LG CD79A
24 heterophyiasis 10.3 CD40LG CD79A
25 orbital granuloma 10.3 CD40LG CD79A
26 transient hypogammaglobulinemia of infancy 10.3 CD40LG CD79A
27 hyperglobulinemic purpura 10.3 CD40LG CD79A
28 gastroduodenitis 10.3 CD40LG CD79A
29 bacterial conjunctivitis 10.3 CD40LG CD79A
30 heavy chain disease 10.3 CD40LG CD79A
31 ophthalmia neonatorum 10.3 CD40LG CD79A
32 immunoglobulin a deficiency 1 10.3 CD40LG CD79A
33 parotid disease 10.3 CD40LG CD79A
34 cerebral arteritis 10.3 CD40LG CD79A
35 selective immunoglobulin deficiency disease 10.3 CD40LG CD79A
36 geniculate herpes zoster 10.3 CD40LG CD79A
37 erythema elevatum diutinum 10.3 CD40LG CD79A
38 sporotrichosis 10.3 CD40LG CD79A
39 fallopian tube disease 10.3 CD40LG CD79A
40 hyperimmunoglobulin syndrome 10.3 CD40LG CD79A
41 congenital syphilis 10.3 CD40LG CD79A
42 polyclonal hypergammaglobulinemia 10.3 CD40LG CD79A
43 monoclonal paraproteinemia 10.3 CD40LG CD79A
44 salpingitis 10.3 CD40LG CD79A
45 dysgammaglobulinemia 10.3 CD40LG CD79A
46 congenital hypogammaglobulinemia 10.3 CD40LG CD79A
47 acute maxillary sinusitis 10.3 CD40LG CD79A
48 chronic polyneuropathy 10.3 CD40LG CD79A
49 spinocerebellar ataxia, autosomal recessive 10 10.3 CD40LG CD79A
50 parasitic ichthyosporea infectious disease 10.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Immunoglobulin G Deficiency:



Diseases related to Immunoglobulin G Deficiency

Symptoms & Phenotypes for Immunoglobulin G Deficiency

Drugs & Therapeutics for Immunoglobulin G Deficiency

Drugs for Immunoglobulin G Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
5 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
6 gamma-Globulins Phase 4,Phase 3,Phase 2
7 Antibodies Phase 4,Phase 3,Phase 2,Not Applicable
8 Immunoglobulins Phase 4,Phase 3,Phase 2,Not Applicable
9 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
10 Renal Agents Phase 4
11 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
12 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
13 Vitamin B Complex Phase 4
14 Antibiotics, Antitubercular Phase 4,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 2
16 Antiparasitic Agents Phase 4
17 Antiprotozoal Agents Phase 4
18 Antitubercular Agents Phase 4
19 Antimalarials Phase 4
20 Folate Nutraceutical Phase 4
21 Vitamin B9 Nutraceutical Phase 4
22 Immunoglobulin G Phase 3,Phase 2
23 Heptavalent Pneumococcal Conjugate Vaccine Phase 2
24 Vaccines Phase 2
25 Immunoglobulin A Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Deficient Subclass or Anti-polysaccharide Antibody Response Completed NCT00522821 Phase 4 intravenous immunoglobulins;antibiotics
2 IVIG Treatment for Asthmatic Patients With IgG Subclass Deficiency Unknown status NCT01992328 Phase 3 Immune Globulin
3 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
4 Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00168025 Phase 3 Immunoglobulins Intravenous (Human)
5 Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00168012 Phase 3 Immunoglobulins Intravenous (Human)
6 PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency Completed NCT01847781 Phase 2
7 Efficacy of IgIv in Patients With IgG Subclass Deficiency and Recurrent Infections Completed NCT00417573 Phase 2 IV Gamunex 10%
8 Susceptibility to Infections in Ataxia Telangiectasia Completed NCT02345135 Not Applicable

Search NIH Clinical Center for Immunoglobulin G Deficiency

Genetic Tests for Immunoglobulin G Deficiency

Genetic tests related to Immunoglobulin G Deficiency:

# Genetic test Affiliating Genes
1 Igg Deficiency 29

Anatomical Context for Immunoglobulin G Deficiency

MalaCards organs/tissues related to Immunoglobulin G Deficiency:

41
Brain, Skin, Spinal Cord

Publications for Immunoglobulin G Deficiency

Articles related to Immunoglobulin G Deficiency:

(show all 11)
# Title Authors Year
1
Immunoglobulin G Deficiency-Associated Septic Arthritis Identified Following Corticosteroid Injection and Knee Arthroscopy: A Case Report. ( 29252646 )
2016
2
Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome. ( 27848135 )
2016
3
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia. ( 25959599 )
2015
4
IgG deficiency and expansion of CTG repeats in myotonic dystrophy. ( 21371814 )
2011
5
Immunoglobulin G deficiency in United kingdom children with invasive pneumococcal disease. ( 21487328 )
2011
6
Recurrent erysipelas in myotonic dystrophy type 1 with IgG deficiency. ( 17389801 )
2007
7
Localization of extrapulmonary tuberculosis in the synovial membrane, skin, and meninges in a patient with systemic lupus erythematosus and IgG deficiency. ( 12120911 )
2002
8
Acquired total immunoglobulin G deficiency in a patient with primary biliary cirrhosis. ( 7673860 )
1995
9
IgG deficiency in adults with recurrent respiratory infections. ( 8498735 )
1993
10
Selective IgG deficiency with a transcriptional disorder of the gamma switching region gene and the IL-4 gene. ( 2278996 )
1990
11
A case of selective immunoglobulin G-deficiency: analysis of coculture with normal lymphocytes in vitro. ( 7460398 )
1981

Variations for Immunoglobulin G Deficiency

Expression for Immunoglobulin G Deficiency

Search GEO for disease gene expression data for Immunoglobulin G Deficiency.

Pathways for Immunoglobulin G Deficiency

Pathways related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.18 CD79A IGHE
2 10.76 CD40LG IGHE
3 10.19 CD40LG CD79A

GO Terms for Immunoglobulin G Deficiency

Cellular components related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD40LG CD79A IGHE

Biological processes related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.33 CD79A IGHE MBL2
2 B cell receptor signaling pathway GO:0050853 9.26 CD79A IGHE
3 B cell differentiation GO:0030183 8.96 CD40LG CD79A
4 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Immunoglobulin G Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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