MCID: IMM044
MIFTS: 32

Immunoglobulin G Deficiency

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Immunoglobulin G Deficiency

MalaCards integrated aliases for Immunoglobulin G Deficiency:

Name: Immunoglobulin G Deficiency 20 70
Igg Deficiency 20 29 54 70
Igg Subclass Deficiency 20 54

Classifications:



External Ids:

UMLS 70 C0162539 C4076140

Summaries for Immunoglobulin G Deficiency

GARD : 20 Immunoglobulin G (IgG) deficiency is a condition that involves the immune system and is characterized by a shortage of type G antibodies. There are four different subclasses of IgG: IgG1, IgG2, IgG3, and IgG4. People with IgG deficiency may have a decreased amount of one or more of the IgG subclasses or a shortage of other types of antibodies, which may occur in various conditions including X-linked agammaglobulinemia, common variable immunodeficiency, and hyper-IgM syndrome. Individuals with IgG deficiency may have an increased susceptibility to infection, but the symptoms of this condition are variable and some people never experience any symptoms. Treatment may involve antibiotics and intravenous (IV) immunoglobulin.

MalaCards based summary : Immunoglobulin G Deficiency, also known as igg deficiency, is related to immunoglobulin alpha deficiency and immunoglobulin a deficiency 1. An important gene associated with Immunoglobulin G Deficiency is CD79A (CD79a Molecule), and among its related pathways/superpathways are Immune response NFAT in immune response and Antigen activates B Cell Receptor (BCR) leading to generation of second messengers. The drugs Levoleucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include liver, myeloid and bone marrow.

Related Diseases for Immunoglobulin G Deficiency

Diseases related to Immunoglobulin G Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 immunoglobulin alpha deficiency 30.4 MBL2 CD79A CD40LG
2 immunoglobulin a deficiency 1 30.0 CD79A CD40LG
3 agammaglobulinemia, x-linked 29.9 CD79A CD40LG
4 otitis media 29.8 MBL2 IGHE CD79A
5 agammaglobulinemia 29.7 CD79A CD40LG
6 membranous nephropathy 29.7 MBL2 CD79A
7 tetanus 29.4 CD79A CD40LG
8 glomerulonephritis 29.3 MBL2 CD79A CD40LG
9 immune deficiency disease 29.0 MBL2 CD79A CD40LG
10 common variable immunodeficiency 29.0 MBL2 FCGRT CD79A CD40LG
11 respiratory papillomatosis, juvenile recurrent, congenital 29.0 MBL2 CD79A CD40LG
12 vasculitis 28.9 MBL2 CD79A CD40LG
13 asthma 28.8 MBL2 IGHE CD79A CD40LG
14 immunoglobulin kappa light chain deficiency 11.6
15 selective igg deficiency disease 11.3
16 specific antibody deficiency 11.3
17 diphtheria 10.2
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
19 cholera 10.1
20 gastroenteritis 10.1
21 purpura 10.1
22 exercise-induced anaphylaxis 10.1 IGHE CD79A
23 anisakiasis 10.1 IGHE CD79A
24 clonorchiasis 10.1 IGHE CD79A
25 strongyloidiasis 10.0 IGHE CD79A
26 toxoplasmosis 10.0 CD79A CD40LG
27 milk allergy 10.0 IGHE CD79A
28 hemorrhagic fever-renal syndrome 10.0 CD79A CD40LG
29 c1q nephropathy 10.0 CD79A CD40LG
30 cryofibrinogenemia 10.0 CD79A CD40LG
31 congenital syphilis 10.0 CD79A CD40LG
32 syphilis 10.0 CD79A CD40LG
33 secondary syphilis 10.0 CD79A CD40LG
34 pustulosis palmaris et plantaris 10.0 CD79A CD40LG
35 calciphylaxis 10.0 CD79A CD40LG
36 congenital toxoplasmosis 10.0 CD79A CD40LG
37 persistent generalized lymphadenopathy 10.0 CD79A CD40LG
38 episodic angioedema with eosinophilia 10.0 IGHE CD40LG
39 lymphoplasmacytic lymphoma 10.0 CD79A CD40LG
40 bacteriuria 10.0 CD79A CD40LG
41 amyotrophic lateral sclerosis 1 10.0
42 hashimoto thyroiditis 10.0
43 hyper-ige recurrent infection syndrome 1, autosomal dominant 10.0
44 thrombocytopenic purpura, autoimmune 10.0
45 ataxia-telangiectasia 10.0
46 hemochromatosis, type 1 10.0
47 ataxia and polyneuropathy, adult-onset 10.0
48 leukemia, acute myeloid 10.0
49 body mass index quantitative trait locus 1 10.0
50 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.0

Graphical network of the top 20 diseases related to Immunoglobulin G Deficiency:



Diseases related to Immunoglobulin G Deficiency

Symptoms & Phenotypes for Immunoglobulin G Deficiency

Drugs & Therapeutics for Immunoglobulin G Deficiency

Drugs for Immunoglobulin G Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
5 Immunoglobulins Phase 4
6 Vitamin B Complex Phase 4
7 Folate Phase 4
8 Anti-Bacterial Agents Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Immunologic Factors Phase 4
11 Rho(D) Immune Globulin Phase 4
12 gamma-Globulins Phase 4
13 Anti-Infective Agents Phase 4
14 Vitamin B9 Phase 4
15 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
16 Immunoglobulins, Intravenous Phase 4
17 Antibodies Phase 4
18 Immunoglobulin G Phase 3
19 Vaccines Phase 2
20 Heptavalent Pneumococcal Conjugate Vaccine Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment in Patients With Recurrent Infections and IgG Subclass Deficiency, and/or Deficient Anti-Polysaccharide Antibody Response Completed NCT00522821 Phase 4 intravenous immunoglobulins;antibiotics
2 IVIG Treatment for Asthmatic Patients With IgG Subclass Deficiency Unknown status NCT01992328 Phase 3 Immune Globulin
3 A Multicenter Extension Study on the Safety and Efficacy of IgPro10 in Patients With Primary Immunodeficiency (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
4 A Multicenter Study on the Efficacy, Safety and Pharmacokinetics of IgPro10 in Patients With Primary Immunodeficiency (PID) Completed NCT00168025 Phase 3 Immunoglobulins Intravenous (Human)
5 An Open Study to Evaluate the Safety and Efficacy of IVIG-F10 in Patients With Primary Immunodeficiency Diseases (PID) Completed NCT00168012 Phase 3 Immunoglobulins Intravenous (Human)
6 Efficacy of IgIv in Patients With IgG Subclass Deficiency and Recurrent Infections Completed NCT00417573 Phase 2 IV Gamunex 10%
7 PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency Completed NCT01847781 Phase 2

Search NIH Clinical Center for Immunoglobulin G Deficiency

Genetic Tests for Immunoglobulin G Deficiency

Genetic tests related to Immunoglobulin G Deficiency:

# Genetic test Affiliating Genes
1 Igg Deficiency 29

Anatomical Context for Immunoglobulin G Deficiency

MalaCards organs/tissues related to Immunoglobulin G Deficiency:

40
Liver, Myeloid, Bone Marrow, Spinal Cord, B Cells, Lung

Publications for Immunoglobulin G Deficiency

Articles related to Immunoglobulin G Deficiency:

(show top 50) (show all 108)
# Title Authors PMID Year
1
Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model. 54 61
17046328 2007
2
Immunoglobulin induction therapy in renal transplant recipients: Effects on immunoglobulin and regulatory antibody levels. 54 61
17175311 2006
3
The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. 61 54
14663287 2003
4
[The hyper-IgM syndrome: 13 observations]. 54 61
12714921 2003
5
Serum immunoglobulins and IgG subclass levels in adults with chronic sinusitis: evidence for decreased IgG3 levels. 54 61
8203794 1994
6
Immunoglobulin G Deficiency in Children with Recurrent Respiratory Infections with and Without History of Allergy. 61
32519307 2021
7
Immunoglobulin Deficiency as an Indicator of Disease Severity in Patients with COVID-19. 61
33237794 2020
8
Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum. 61
32239366 2020
9
Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies. 61
31430592 2020
10
Total absence of the pericardium associated with hypogammaglobulinemia and bronchiectasis in a girl. 61
31871606 2019
11
De novo bronchiectasis in haematological malignancies: patient characteristics, risk factors and survival. 61
31720297 2019
12
Asthma as aetiology of bronchiectasis in Finland. 61
31128603 2019
13
Differentiation of Common Variable Immunodeficiency From IgG Deficiency. 61
30557717 2019
14
Gamma globulin replacement therapy in uncontrolled, severe asthma associated with humoral immunodeficiency: A series of five case reports. 61
29420096 2019
15
Recurrent Septic Shock and Syncope: An Unusual Combination. 61
31331154 2018
16
Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency. 61
29128760 2018
17
Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome. 61
27848135 2017
18
The Pneumocell-study: Vaccination of IgG1- and IgG2-deficient patients with Prevnar13. 61
28410816 2017
19
Agammaglobulinaemia despite terminal B-cell differentiation in a patient with a novel LRBA mutation. 61
28690850 2017
20
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study. 61
27555459 2017
21
Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. 61
29276421 2017
22
Immunoglobulin G Deficiency-Associated Septic Arthritis Identified Following Corticosteroid Injection and Knee Arthroscopy: A Case Report. 61
29252646 2016
23
Secondary Antibody Deficiency in Glucocorticoid Therapy Clearly Differs from Primary Antibody Deficiency. 61
26980224 2016
24
Detection of the Dimorphic Phases of Mucor circinelloides in Blood Cultures from an Immunosuppressed Female. 61
27777804 2016
25
Immunoglobulin deficiency in patients with chronic rhinosinusitis: Systematic review of the literature and meta-analysis. 61
26329513 2015
26
Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension. 61
26351030 2015
27
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia. 61
25959599 2015
28
Endobronchial deposits of chronic lymphocytic leukemia - an unusual cause of central airway obstruction. 61
26090107 2015
29
Recurrent C. difficile in a Patient with IgG Deficiency. 61
25945268 2015
30
[Classic Kaposi sarcoma associated with IgG deficiency]. 61
23122615 2013
31
Serum killing of Ureaplasma parvum shows serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients. 61
21802767 2012
32
IgG deficiency and expansion of CTG repeats in myotonic dystrophy. 61
21371814 2011
33
Immunoglobulin G deficiency in United kingdom children with invasive pneumococcal disease. 61
21487328 2011
34
Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases. 61
21695153 2011
35
Immunoglobulin G subclass deficiency is the major phenotype of primary immunodeficiency in a Korean adult cohort. 61
20514300 2010
36
The outcome of patients with unclassified hypogammaglobulinemia in early childhood. 54
19196447 2009
37
Down-Syndrome associated with MBL-deficiency, IgG-deficiency, vasculitis and mutated prothrombin. 61
19399328 2009
38
Results of endoscopic maxillary mega-antrostomy in recalcitrant maxillary sinusitis. 61
19178809 2008
39
Ruptured inflammatory aortic aneurysm with aortoenteric fistula and infected with Streptococcus pneumoniae: a review of the literature. 61
23133042 2008
40
Alterations in humoral immunity in relatives of patients with common variable immunodeficiency. 54
18714534 2008
41
[IgIV at home:experience of a center--economic aspects]. 61
17768832 2007
42
Collagenous duodeno-ileo-colitis with transient IgG deficiency preceded by Yersinia enterocolitica intestinal infection: case report and review of literature. 61
17408550 2007
43
Increases in serum immunoglobulins to age-related normal levels in children with IgA and/or IgG subclass deficiency. 54
17338791 2007
44
Recurrent erysipelas in myotonic dystrophy type 1 with IgG deficiency. 61
17389801 2007
45
[Economic evaluation of at home subcutaneous and intravenous immunoglobulin substitution]. 61
17011081 2006
46
No evidence for prolonged excretion of polioviruses in persons with residual paralytic poliomyelitis in Ethiopia, Pakistan and Guatemala. 61
16682222 2006
47
Variability of immunodeficiency associated with ataxia telangiectasia and clinical evolution in 12 affected patients. 61
16238588 2005
48
IgA deficiency: clinical correlates with IgG subclass and mannan-binding lectin deficiencies. 54
16116926 2005
49
IgA and/or IgG subclass deficiency in children with recurrent respiratory infections and its relationship with chronic pulmonary damage. 54
15864886 2005
50
Carbamazepine-induced IgG1 and IgG2 deficiency associated with B cell maturation defect. 61
15010058 2004

Variations for Immunoglobulin G Deficiency

Expression for Immunoglobulin G Deficiency

Search GEO for disease gene expression data for Immunoglobulin G Deficiency.

Pathways for Immunoglobulin G Deficiency

Pathways related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 IGHE CD79A CD40LG
2
Show member pathways
11.28 IGHE CD79A
3 10.96 IGHE CD40LG
4 10.2 CD79A CD40LG

GO Terms for Immunoglobulin G Deficiency

Cellular components related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IGHE FCGRT CD79A CD40LG

Biological processes related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.5 MBL2 IGHE CD79A
2 complement activation, classical pathway GO:0006958 9.37 MBL2 IGHE
3 B cell receptor signaling pathway GO:0050853 9.26 IGHE CD79A
4 B cell differentiation GO:0030183 9.16 CD79A CD40LG
5 immune response GO:0006955 9.13 IGHE FCGRT CD40LG
6 B cell proliferation GO:0042100 8.62 CD79A CD40LG

Sources for Immunoglobulin G Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....