MCID: IMM044
MIFTS: 35

Immunoglobulin G Deficiency

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Immunoglobulin G Deficiency

MalaCards integrated aliases for Immunoglobulin G Deficiency:

Name: Immunoglobulin G Deficiency 54 74
Igg Deficiency 54 30 56 74
Igg Subclass Deficiency 54 56

Classifications:



External Ids:

Summaries for Immunoglobulin G Deficiency

NIH Rare Diseases : 54 Immunoglobulin G (IgG) deficiency is a condition that involves the immune system and is characterized by a shortage of type G antibodies. There are four different subclasses of IgG: IgG1, IgG2, IgG3, and IgG4. People with IgG deficiency may have a decreased amount of one or more of the IgG subclasses or a shortage of other types of antibodies, which may occur in various conditions including X-linked agammaglobulinemia, common variable immunodeficiency, and hyper-IgM syndrome. Individuals with IgG deficiency may have an increased susceptibility to infection, but the symptoms of this condition are variable and some people never experience any symptoms. Treatment may involve antibiotics and intravenous (IV) immunoglobulin.

MalaCards based summary : Immunoglobulin G Deficiency, also known as igg deficiency, is related to glomerulonephritis and immunoglobulin alpha deficiency. An important gene associated with Immunoglobulin G Deficiency is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Immune response NFAT in immune response. The drugs Sulfamethoxazole and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and testes, and related phenotype is renal/urinary system.

Related Diseases for Immunoglobulin G Deficiency

Diseases related to Immunoglobulin G Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 29.9 CD40LG CD79A
2 immunoglobulin alpha deficiency 29.8 CD40LG CD79A MBL2
3 common variable immunodeficiency 28.9 CD40LG CD79A MBL2
4 systemic lupus erythematosus 28.4 CD40LG CD79A MBL2
5 immunoglobulin kappa light chain deficiency 11.7
6 specific antibody deficiency 11.4
7 selective igg deficiency disease 11.3
8 exercise-induced anaphylaxis 10.1 CD79A IGHE
9 agammaglobulinemia 10.0
10 lung disease 10.0
11 toxoplasmosis 10.0 CD40LG CD79A
12 episodic angioedema with eosinophilia 10.0 CD40LG IGHE
13 c1q nephropathy 10.0 CD40LG CD79A
14 cryofibrinogenemia 10.0 CD40LG CD79A
15 heparin-induced thrombocytopenia 10.0 CD40LG CD79A
16 immunoglobulin a deficiency 1 10.0 CD40LG CD79A
17 sporotrichosis 10.0 CD40LG CD79A
18 congenital syphilis 10.0 CD40LG CD79A
19 syphilis 10.0 CD40LG CD79A
20 secondary syphilis 10.0 CD40LG CD79A
21 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.0 CD40LG CD79A
22 persistent generalized lymphadenopathy 10.0 CD40LG CD79A
23 congenital toxoplasmosis 10.0 CD40LG CD79A
24 cryptosporidiosis 10.0 CD40LG CD79A
25 pustulosis palmaris et plantaris 9.9 CD40LG CD79A
26 dysgerminoma of ovary 9.9 CD40LG CD79A
27 marginal zone b-cell lymphoma 9.9 CD40LG CD79A
28 agammaglobulinemia, x-linked 9.9 CD40LG CD79A
29 meningoencephalitis 9.9 CD40LG CD79A
30 leukemia, chronic lymphocytic 2 9.9
31 leukemia, chronic lymphocytic 9.9
32 ataxia-telangiectasia 9.9
33 hemochromatosis, type 1 9.9
34 leukemia 9.9
35 liver disease 9.9
36 lymphocytic leukemia 9.9
37 bacterial infectious disease 9.9
38 cardiac tamponade 9.9
39 cholera 9.9
40 candidiasis 9.9
41 chronic mucocutaneous candidiasis 9.9
42 bronchitis 9.9
43 monoclonal gammopathy of uncertain significance 9.9
44 meningitis 9.9
45 bronchiectasis 9.9
46 juvenile hereditary hemochromatosis 9.9
47 leukemia, b-cell, chronic 9.9
48 pneumococcal meningitis 9.9
49 cryoglobulinemia 9.9 CD40LG CD79A
50 immune deficiency disease 9.9 CD40LG CD79A

Graphical network of the top 20 diseases related to Immunoglobulin G Deficiency:



Diseases related to Immunoglobulin G Deficiency

Symptoms & Phenotypes for Immunoglobulin G Deficiency

MGI Mouse Phenotypes related to Immunoglobulin G Deficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.8 CD40LG CD79A MBL2

Drugs & Therapeutics for Immunoglobulin G Deficiency

Drugs for Immunoglobulin G Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
leucovorin Approved Phase 4 58-05-9 143 6006
3
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
5 Immunoglobulins Phase 4,Phase 3,Phase 2,Not Applicable
6 Antibodies Phase 4,Phase 3,Phase 2,Not Applicable
7 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
8 gamma-Globulins Phase 4,Phase 3,Phase 2
9 Immunologic Factors Phase 4,Phase 3,Phase 2
10 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
11 Antibiotics, Antitubercular Phase 4,Not Applicable
12 Anti-Infective Agents Phase 4,Phase 2
13 Vitamin B9 Phase 4
14 Vitamin B Complex Phase 4
15 Anti-Infective Agents, Urinary Phase 4
16 Antimalarials Phase 4
17 Antiparasitic Agents Phase 4
18 Antitubercular Agents Phase 4
19 Folate Phase 4
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
21 Renal Agents Phase 4
22 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
23 Antiprotozoal Agents Phase 4
24 Immunoglobulin G Phase 3,Phase 2
25
Ustekinumab Approved, Investigational Phase 1, Phase 2 815610-63-0
26 Heptavalent Pneumococcal Conjugate Vaccine Phase 2
27 Vaccines Phase 2
28 Interleukin-12 Phase 1, Phase 2
29 Dermatologic Agents Phase 1, Phase 2
30 Immunoglobulin A Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Deficient Subclass or Anti-polysaccharide Antibody Response Completed NCT00522821 Phase 4 intravenous immunoglobulins;antibiotics
2 IVIG Treatment for Asthmatic Patients With IgG Subclass Deficiency Unknown status NCT01992328 Phase 3 Immune Globulin
3 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
4 Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00168025 Phase 3 Immunoglobulins Intravenous (Human)
5 Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00168012 Phase 3 Immunoglobulins Intravenous (Human)
6 PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency Completed NCT01847781 Phase 2
7 Efficacy of IgIv in Patients With IgG Subclass Deficiency and Recurrent Infections Completed NCT00417573 Phase 2 IV Gamunex 10%
8 Study of Safety, Tolerability, and Efficacy of Ustekinumab for Symptomatic Gastrointestinal Inflammation Associated With Common Variable Immunodeficiency Active, not recruiting NCT02199496 Phase 1, Phase 2
9 Susceptibility to Infections in Ataxia Telangiectasia Completed NCT02345135 Not Applicable

Search NIH Clinical Center for Immunoglobulin G Deficiency

Genetic Tests for Immunoglobulin G Deficiency

Genetic tests related to Immunoglobulin G Deficiency:

# Genetic test Affiliating Genes
1 Igg Deficiency 30

Anatomical Context for Immunoglobulin G Deficiency

MalaCards organs/tissues related to Immunoglobulin G Deficiency:

42
Brain, Skin, Testes, Spinal Cord, Lung, Liver, Ovary

Publications for Immunoglobulin G Deficiency

Articles related to Immunoglobulin G Deficiency:

(show all 23)
# Title Authors Year
1
Differentiation of Common Variable Immunodeficiency from Igg Deficiency. ( 30557717 )
2018
2
Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome. ( 27848135 )
2017
3
Immunoglobulin G Deficiency-Associated Septic Arthritis Identified Following Corticosteroid Injection and Knee Arthroscopy: A Case Report. ( 29252646 )
2016
4
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia. ( 25959599 )
2015
5
Recurrent C. difficile in a Patient with IgG Deficiency. ( 25945268 )
2015
6
Immunoglobulin G deficiency in United kingdom children with invasive pneumococcal disease. ( 21487328 )
2011
7
IgG deficiency and expansion of CTG repeats in myotonic dystrophy. ( 21371814 )
2011
8
Down-Syndrome associated with MBL-deficiency, IgG-deficiency, vasculitis and mutated prothrombin. ( 19399328 )
2009
9
Recurrent erysipelas in myotonic dystrophy type 1 with IgG deficiency. ( 17389801 )
2007
10
Collagenous duodeno-ileo-colitis with transient IgG deficiency preceded by Yersinia enterocolitica intestinal infection: case report and review of literature. ( 17408550 )
2007
11
Localization of extrapulmonary tuberculosis in the synovial membrane, skin, and meninges in a patient with systemic lupus erythematosus and IgG deficiency. ( 12120911 )
2002
12
Immediate hypersensitivity in adults with IgG deficiency and recurrent respiratory infections. ( 10400485 )
1999
13
Lupus vulgaris in a patient with systemic lupus erythematosus and persistent IgG deficiency. ( 9032821 )
1997
14
Acquired total immunoglobulin G deficiency in a patient with primary biliary cirrhosis. ( 7673860 )
1995
15
Airway obstruction in adults with recurrent respiratory infections and IgG deficiency. ( 8162726 )
1994
16
IgG deficiency in adults with recurrent respiratory infections. ( 8498735 )
1993
17
Selective IgG deficiency with a transcriptional disorder of the gamma switching region gene and the IL-4 gene. ( 2278996 )
1990
18
Fatal sepsis due to Branhamella catarrhalis and Hemophilus influenzae in a child with selective IgG deficiency. ( 6603206 )
1983
19
A case of selective immunoglobulin G-deficiency: analysis of coculture with normal lymphocytes in vitro. ( 7460398 )
1981
20
Selective IgG deficiency (a case report). ( 6790512 )
1981
21
Isolated IgG deficiency: clinical, immunologic, and pathologic investigations. ( 7381657 )
1980
22
IgG deficiency in association with placental oedema. ( 617305 )
1977
23
A screening test for IgG deficiency. ( 4633855 )
1973

Variations for Immunoglobulin G Deficiency

Expression for Immunoglobulin G Deficiency

Search GEO for disease gene expression data for Immunoglobulin G Deficiency.

Pathways for Immunoglobulin G Deficiency

GO Terms for Immunoglobulin G Deficiency

Cellular components related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD40LG CD79A IGHE

Biological processes related to Immunoglobulin G Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.37 IGHE MBL2
2 immune system process GO:0002376 9.33 CD79A IGHE MBL2
3 complement activation, classical pathway GO:0006958 9.32 IGHE MBL2
4 B cell receptor signaling pathway GO:0050853 9.26 CD79A IGHE
5 B cell differentiation GO:0030183 8.96 CD40LG CD79A
6 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Immunoglobulin G Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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