MCID: IMM053
MIFTS: 26

Immunotactoid Glomerulopathy

Categories: Immune diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Immunotactoid Glomerulopathy

MalaCards integrated aliases for Immunotactoid Glomerulopathy:

Name: Immunotactoid Glomerulopathy 52 58
Immunotactoid Glomerulonephritis 52 58
Fibrillary Glomerulonephritis 71

Characteristics:

Orphanet epidemiological data:

58
immunotactoid glomerulopathy
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare renal diseases


External Ids:

ICD10 via Orphanet 33 N03.6
UMLS via Orphanet 72 C0268749 C2242534
Orphanet 58 ORPHA97567
UMLS 71 C0268749

Summaries for Immunotactoid Glomerulopathy

NIH Rare Diseases : 52 Immunotactoid glomerulopathy , also known as glomerulonephritis with organized monoclonal microtubular immunoglobulin deposits (GOMMID), is a very uncommon cause of glomerular disease . It is related to a similar disease known as fibrillary glomerulopathy , which is more common. Both disorders probably result from deposits derived from immunoglobulins, but in most cases the cause is idiopathic (unknown). On electron microscopy , immunotactoid glomerulopathy is characterized by the formation of microtubules which are much larger than the fibrils observed in fibrillary glomerulonephritis (30 to 50 versus 16 to 24 nm in diameter). The signs and symptoms include blood (hematuria) and protein (proteinuria ) in the urine, kidney insufficiency and high blood pressure . Both fibrillary glomerulonephritis and immunotactoid glomerulopathy have been associated with hepatitis C virus infection and with malignancy and autoimmune disease . Also, patients with immunotactoid glomerulopathy have a greater risk to have chronic lymphocytic leukemia and B cell lymphomas and should be screened for all of these conditions. Treatment is generally determined by the severity of the kidney problems.

MalaCards based summary : Immunotactoid Glomerulopathy, also known as immunotactoid glomerulonephritis, is related to immunotactoid or fibrillary glomerulopathy and fibrillary glomerulonephritis. An important gene associated with Immunotactoid Glomerulopathy is ALB (Albumin). The drugs Tacrolimus and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include kidney, b cells and bone.

Related Diseases for Immunotactoid Glomerulopathy

Diseases related to Immunotactoid Glomerulopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 immunotactoid or fibrillary glomerulopathy 12.6
2 fibrillary glomerulonephritis 12.1
3 glomerulopathy with fibronectin deposits 2 11.5
4 glomerulonephritis 10.9
5 nephrotic syndrome 10.8
6 cryoglobulinemia 10.7
7 amyloidosis 10.7
8 end stage renal failure 10.6
9 membranoproliferative glomerulonephritis 10.5
10 glomerular disease 10.5
11 mesangial proliferative glomerulonephritis 10.4
12 vasculitis 10.4
13 leukemia, chronic lymphocytic 10.3
14 lymphoma, hodgkin, classic 10.3
15 myeloma, multiple 10.3
16 lymphoma, non-hodgkin, familial 10.3
17 lymphocytic leukemia 10.3
18 polyneuropathy 10.3
19 poems syndrome 10.3
20 acute kidney failure 10.3
21 plasma cell neoplasm 10.3
22 autoimmune disease 10.1
23 endosteal hyperostosis, autosomal dominant 10.1
24 systemic lupus erythematosus 10.1
25 rheumatoid arthritis 10.1
26 down syndrome 10.1
27 mycosis fungoides 10.1
28 sickle cell anemia 10.1
29 hypereosinophilic syndrome, idiopathic 10.1
30 mycobacterium tuberculosis 1 10.1
31 membranous nephropathy 10.1
32 deficiency anemia 10.1
33 diffuse large b-cell lymphoma 10.1
34 lymphoplasmacytic lymphoma 10.1
35 follicular lymphoma 10.1
36 heavy chain disease 10.1
37 gamma heavy chain disease 10.1
38 lymphoproliferative syndrome 10.1
39 castleman disease 10.1
40 thalassemia 10.1
41 neutropenia 10.1
42 angioedema 10.1
43 hepatitis c 10.1
44 purpura 10.1
45 mixed connective tissue disease 10.1
46 plasmacytoma 10.1
47 liver disease 10.1
48 rapidly progressive glomerulonephritis 10.1
49 proliferative glomerulonephritis 10.1
50 kidney disease 10.1

Graphical network of the top 20 diseases related to Immunotactoid Glomerulopathy:



Diseases related to Immunotactoid Glomerulopathy

Symptoms & Phenotypes for Immunotactoid Glomerulopathy

Drugs & Therapeutics for Immunotactoid Glomerulopathy

Drugs for Immunotactoid Glomerulopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
2 Immunologic Factors Phase 4
3 Pharmaceutical Solutions Phase 4
4 Adrenocorticotropic Hormone Phase 4
5 Melanocyte-Stimulating Hormones Phase 4
6 Hormone Antagonists Phase 4
7 beta-endorphin Phase 4
8 Immunosuppressive Agents Phase 4
9 Hormones Phase 4
10 Calcineurin Inhibitors Phase 4
11
rituximab Approved Phase 2 174722-31-7 10201696
12 Antineoplastic Agents, Immunological Phase 2
13 Antirheumatic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenterer, Comparative Safety Andof ACTHar Gel Alone or in Cwith oe Urinary in Patients Positive Fibrillary Glomerulopathy Recruiting NCT04080076 Phase 4 Acthar 80 UNT/ML Injectable Solution;Tacrolimus capsule
2 A Single Center Pilot Trial of Rituximab in the Treatment of Fibrillary Glomerulonephritis Completed NCT02197767 Phase 2 rituximab
3 Different Histopathological Patterns in Patients With HCV Nephropathy Not yet recruiting NCT03476031

Search NIH Clinical Center for Immunotactoid Glomerulopathy

Genetic Tests for Immunotactoid Glomerulopathy

Anatomical Context for Immunotactoid Glomerulopathy

MalaCards organs/tissues related to Immunotactoid Glomerulopathy:

40
Kidney, B Cells, Bone, Liver, Bone Marrow, Skin

Publications for Immunotactoid Glomerulopathy

Articles related to Immunotactoid Glomerulopathy:

(show top 50) (show all 141)
# Title Authors PMID Year
1
Case of immunotactoid glomerulopathy showing high responsiveness to steroids therapy despite severe pathological features. 61
31350228 2019
2
Monoclonal Immunoglobulin Deposition Disease and Related Diseases. 61
30918151 2019
3
HCV-Associated Nephropathies in the Era of Direct Acting Antiviral Agents. 61
30800660 2019
4
Rare diagnosis in a patient with diabetes with nephrotic proteinuria. 61
30635300 2019
5
Successful treatment with rituximab of immunotactoid glomerulopathy exhibiting nephrotic syndrome‚Ä©. 61
30049299 2018
6
The Complexity and Heterogeneity of Monoclonal Immunoglobulin-Associated Renal Diseases. 61
29703839 2018
7
A case of immunotactoid glomerulopathy with false-negative IgG staining. 61
29907095 2018
8
A case report of POEMS syndrome with renal involvement as immunotactoid glomerulopathy. 61
29489695 2018
9
DNAJB9 Is a Specific Immunohistochemical Marker for Fibrillary Glomerulonephritis. 61
29340314 2018
10
Dysproteinemias and Glomerular Disease. 61
29114004 2018
11
Fibrillary Glomerulonephritis in Primary Sjogren's Syndrome: A Rare Cause of Renal Failure. 61
29196420 2017
12
The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance. 61
28832010 2017
13
Immunotactoid Glomerulopathy of 10-Years' Duration: Insights Gained From Sequential Biopsies. 61
29270507 2017
14
Immunotactoid glomerulopathy leading to the discovery of POEMS syndrome‚Ä©. 61
28291506 2017
15
Profile of glomerular diseases associated with hepatitis B and C: A single-center experience from India. 61
28352020 2017
16
[Unexpected symptoms of monoclonal gammopathy]. 61
29027517 2017
17
Paraprotein-Related Kidney Disease: Glomerular Diseases Associated with Paraproteinemias. 61
27526706 2016
18
"Diabetic nephropathy" in a non-diabetic patient. 61
27688084 2016
19
Paraprotein-Related Kidney Disease: Kidney Injury from Paraproteins-What Determines the Site of Injury? 61
27526707 2016
20
[Pathology and differential diagnosis of immunotactoid glomerulopathy]. 61
27760612 2016
21
A case report of unusually long lag time between immunotactoid glomerulopathy (itg) diagnosis and diffuse large B-cell lymphoma (DLBCL) development. 61
27686684 2016
22
Idiopathic nodular glomerulosclerosis: Report of two cases and review of literature. 61
27051142 2016
23
Spectrum of manifestations of monoclonal gammopathy-associated renal lesions. 61
26735145 2016
24
[Glomerulopathies with organized monoclonal immunoglobulin deposits]. 61
26810049 2016
25
AJKD Atlas of Renal Pathology: Immunotactoid Glomerulopathy. 61
26408243 2015
26
A case of membranoproliferative glomerulonephritis associated with curved fibril deposition. 61
26370133 2015
27
Monoclonal light chain deposits within the stomach manifesting as immunotactoid gastropathy. 61
25191812 2015
28
Posterior segment findings in a patient with immunotactoid glomerulonephritis. 61
27625945 2015
29
End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases. 61
26418732 2015
30
Immunotactoid Glomerulopathy and Cryoglobulinemic Nephropathy: Two Entities with Many Similarities. A Unified Conceptual Approach. 61
26270724 2015
31
Hepatitis C virus associated glomerulopathies. 61
24976695 2014
32
Pauci-immune crescentic glomerulonephritis in the Down's syndrome. 61
24231490 2013
33
Laser microdissection and proteomic analysis of amyloidosis, cryoglobulinemic GN, fibrillary GN, and immunotactoid glomerulopathy. 61
23411427 2013
34
Immunotactoid glomerulopathy: clinicopathologic and proteomic study. 61
22872726 2012
35
Chronic lymphocytic leukemia associated with immunotactoid glomerulopathy: a case report of successful treatment with high-dose methylprednisolone in combination with rituximab followed by alemtuzumab. 61
22335532 2012
36
Rule-based decision support system in the biopsy diagnosis of glomerular diseases. 61
21666142 2011
37
Hyaline glomerulopathy with tubulo-fibrillary deposits in young ddY mice. 61
21878553 2011
38
[Fibrillary glomerulonephritis and immunotactoid glomerulopathy: case reports]. 61
22165079 2011
39
Spontaneous remission of immunotactoid glomerulopathy. 61
21934180 2011
40
Contribution of electron microscopy to the final diagnosis of renal biopsies in Egyptian patients. 61
20645138 2011
41
An uncommon glomerular disease in an HIV patient: value of renal biopsy and review of the literature. 61
21176755 2011
42
Monoclonal immunoglobulin light and heavy chain deposition diseases: molecular models of common renal diseases. 61
21252522 2011
43
Immunotactoid glomerulopathy and tuberculosis: a novel association. 61
21629347 2011
44
Mixed cryoglobulinaemia not related to hepatitis C virus, mesangiocapillary glomerulonephritis and lymphoplasmocytic lymphoma. 61
22130292 2011
45
[Diagnostic pathway of an unusual case of nephrotic syndrome: immunotactoid glomerulopathy]. 61
21132650 2010
46
A case of immunotactoid glomerulopathy with rapid progression to end-stage renal disease. 61
20024509 2009
47
A case of recurrent immunotactoid glomerulopathy in an allograft treated with rituximab. 61
19917422 2009
48
A case of immunotactoid glomerulopathy exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy. 61
19367362 2009
49
[Immunotactoid glomerulonephritis]. 61
19514359 2009
50
Making the diagnosis of immunotactoid glomerulonephritis. 61
18648811 2009

Variations for Immunotactoid Glomerulopathy

Expression for Immunotactoid Glomerulopathy

Search GEO for disease gene expression data for Immunotactoid Glomerulopathy.

Pathways for Immunotactoid Glomerulopathy

GO Terms for Immunotactoid Glomerulopathy

Sources for Immunotactoid Glomerulopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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