MCID: IMP001
MIFTS: 31

Impetigo Herpetiformis

Categories: Skin diseases

Aliases & Classifications for Impetigo Herpetiformis

MalaCards integrated aliases for Impetigo Herpetiformis:

Name: Impetigo Herpetiformis 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8503
ICD9CM 36 694.3
SNOMED-CT 69 65539006
ICD10 34 L40.1
UMLS 74 C1314968

Summaries for Impetigo Herpetiformis

Disease Ontology : 12 An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy.

MalaCards based summary : Impetigo Herpetiformis is related to impetigo and psoriasis. An important gene associated with Impetigo Herpetiformis is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Defensins and IL-1 Family Signaling Pathways. Affiliated tissues include skin and monocytes, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Impetigo herpetiformis is a form of severe pustular psoriasis occurring in pregnancy which may occur... more...

Related Diseases for Impetigo Herpetiformis

Diseases related to Impetigo Herpetiformis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 impetigo 31.9 ELANE IL36RN PI3
2 psoriasis 30.8 CARD14 IL36RN TNF
3 pustular psoriasis 30.2 CARD14 ELANE IL36RN PI3 TNF
4 hypoparathyroidism 10.4
5 bronchopneumonia 10.3 ELANE PI3
6 rapidly progressive glomerulonephritis 10.3 ELANE PRTN3
7 psoriasis 14, pustular 10.3
8 pityriasis rubra pilaris 10.3 CARD14 IL36RN
9 pustulosis of palm and sole 10.2 IL36RN TNF
10 irritant dermatitis 10.2 PI3 TNF
11 dermatitis herpetiformis, familial 10.2
12 dermatitis 10.2
13 dermatitis herpetiformis 10.2
14 netherton syndrome 10.2 ELANE PI3
15 posterior scleritis 10.2 PRTN3 TNF
16 arthus reaction 10.2 ELANE TNF
17 periodontosis 10.2 ELANE TNF
18 geographic tongue 10.2 IL36RN TNF
19 pyoderma 10.2 IL36RN TNF
20 granulomatosis with polyangiitis 10.2 ELANE PRTN3 SERPINB1
21 bacterial sepsis 10.1 ELANE TNF
22 primary hypomagnesemia 10.1 IL36RN PTH
23 middle ear disease 10.1 PRTN3 TNF
24 churg-strauss syndrome 10.1 PRTN3 TNF
25 palindromic rheumatism 10.1 PRTN3 TNF
26 pustulosis palmaris et plantaris 10.1 ELANE IL36RN TNF
27 farmer's lung 10.1 ELANE PI3 TNF
28 erysipelas 10.1 ELANE PI3 TNF
29 acute respiratory distress syndrome 10.1 ELANE PI3 TNF
30 intrahepatic cholestasis of pregnancy 10.1
31 rickets 10.1
32 hyperparathyroidism 10.1
33 cholestasis 10.1
34 lymphadenitis 10.1
35 pemphigus 10.1
36 pemphigus vegetans 10.1
37 acrodermatitis 10.1 ALB IL36RN
38 pasteurellosis 10.1 ALB ELANE
39 lichen disease 10.1 DST TNF
40 pulmonary disease, chronic obstructive 10.0 ELANE SERPINB1 TNF
41 chronic ulcer of skin 10.0 ALB ELANE
42 capillary leak syndrome 10.0 ALB ELANE
43 peptic ulcer perforation 10.0 ALB ELANE
44 transient arthritis 10.0 ALB PRTN3
45 cellulitis 10.0 DST TNF
46 subcorneal pustular dermatosis 9.9 DST IL36RN
47 burns 9.9 ALB TNF
48 chronic graft versus host disease 9.9 ALB TNF
49 jejunoileitis 9.9 ALB TNF
50 tuberculous peritonitis 9.9 ALB TNF

Graphical network of the top 20 diseases related to Impetigo Herpetiformis:



Diseases related to Impetigo Herpetiformis

Symptoms & Phenotypes for Impetigo Herpetiformis

MGI Mouse Phenotypes related to Impetigo Herpetiformis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 ELANE IL1RL2 IL36RN NLRP1 PRTN3 PTH
2 immune system MP:0005387 9.23 ELANE IL1RL2 IL36RN NLRP1 PRTN3 PTH

Drugs & Therapeutics for Impetigo Herpetiformis

Search Clinical Trials , NIH Clinical Center for Impetigo Herpetiformis

Genetic Tests for Impetigo Herpetiformis

Anatomical Context for Impetigo Herpetiformis

MalaCards organs/tissues related to Impetigo Herpetiformis:

42
Skin, Monocytes

Publications for Impetigo Herpetiformis

Articles related to Impetigo Herpetiformis:

(show top 50) (show all 87)
# Title Authors Year
1
Treatment resistant impetigo herpetiformis treated with infliximab. ( 30693621 )
2019
2
Granulocyte/Monocyte Adsorption Apheresis as a Novel Therapeutic Approach in the Treatment of an Impetigo Herpetiformis Case. ( 29318775 )
2018
3
Impetigo Herpetiformis: Review of Pathogenesis, Complication, and Treatment. ( 29849579 )
2018
4
An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up. ( 30028004 )
2018
5
Impetigo herpetiformis with IL-36RN mutation successfully treated with secukinumab. ( 30105995 )
2018
6
Impetigo herpetiformis: a rare dermotosis of pregnancy. ( 30637058 )
2018
7
Recurrent impetigo herpetiformis: case report. ( 28979621 )
2017
8
Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. ( 27573023 )
2016
9
Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. ( 26104679 )
2015
10
Case report of a rare dermatosis in pregnancy: Impetigo herpetiformis. ( 25303404 )
2014
11
Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis. ( 25413895 )
2014
12
IL36RN mutations underlie impetigo herpetiformis. ( 24717243 )
2014
13
Impetigo Herpetiformis during pregnancy: a case report and literature review. ( 23446290 )
2013
14
Anesthetic management for cesarean delivery of a parturient with impetigo herpetiformis. ( 25611605 )
2013
15
Pustular psoriasis of pregnancy (Impetigo herpetiformis) - case report. ( 24346915 )
2013
16
Cyclosporine in the management of impetigo herpetiformis: a case report and review of the literature. ( 23626548 )
2013
17
Recurrent postpartum impetigo herpetiformis presenting after a "skip" pregnancy. ( 22854922 )
2013
18
A case of recurrent impetigo herpetiformis treated with systemic corticosteroids and narrowband UVB. ( 22264139 )
2012
19
Ritodrine-induced pustular eruptions distinctly resembling impetigo herpetiformis. ( 22041881 )
2011
20
Impetigo herpetiformis with gestational hypertension: a case report and literature review. ( 21494028 )
2011
21
First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. ( 22696729 )
2011
22
Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report. ( 21159049 )
2011
23
Recurrent impetigo herpetiformis with diabetes and hypoalbuminemia successfully treated with cyclosporine, albumin, insulin and metformin. ( 20606891 )
2010
24
Recurrent impetigo herpetiformis successfully treated with methotrexate. ( 18554218 )
2009
25
Impetigo herpetiformis: a rare dermatosis of pregnancy. ( 19864978 )
2009
26
Impetigo herpetiformis during the puerperium triggered by secondary hypoparathyroidism: a case report. ( 20072676 )
2009
27
Impetigo herpetiformis with postpartum flare-up: a case report. ( 19588063 )
2009
28
Postpartum impetigo herpetiformis complicated with hypovolaemic shock. ( 19521302 )
2009
29
Impetigo herpetiformis occurring during N-butyl-scopolammonium bromide therapy in pregnancy: case report. ( 18597707 )
2008
30
Third-trimester impetigo herpetiformis treated with cyclosporine. ( 17224395 )
2007
31
Methotrexate treatment of recurrent impetigo herpetiformis with hypoparathyroidism. ( 16836512 )
2006
32
A case of impetigo herpetiformis associated with intrahepatic cholestasis of pregnancy. ( 16923139 )
2006
33
Impetigo herpetiformis. ( 16487882 )
2006
34
Impetigo herpetiformis with hyperparathyroidism. ( 16268884 )
2005
35
Impetigo herpetiformis--a rare dermatosis of pregnancy associated with prenatal complications. ( 16284679 )
2005
36
Impetigo herpetiformis: menstrual exacerbations for 7 years postpartum. ( 15987295 )
2005
37
Impetigo herpetiformis in a primigravida: successful treatment with etretinate. ( 15303793 )
2004
38
Impetigo herpetiformis unresponsive to therapy in a pregnant adolescent. ( 12804935 )
2003
39
Impetigo herpetiformis followed by generalized pustular psoriasis: more evidence of same disease entity. ( 12956698 )
2003
40
Successful treatment of impetigo herpetiformis with oral cyclosporine during pregnancy. ( 11790187 )
2002
41
Recurrent impetigo herpetiformis in a pregnant adolescent: case report. ( 11858900 )
2002
42
A case of impetigo herpetiformis with unusual clinical features. ( 11476115 )
2001
43
A case of recurrent impetigo herpetiformis with a positive family history. ( 11220992 )
2000
44
Impetigo herpetiformis at the 36th week of gestation. ( 10802084 )
2000
45
Impetigo herpetiformis during the puerperium. ( 10449943 )
1999
46
Generalized pustular psoriasis of pregnancy (impetigo herpetiformis). ( 10026404 )
1999
47
Impetigo herpetiformis: An obstetric concern. ( 17344740 )
1998
48
Extremely low levels of epidermal skin-derived antileucoproteinase/elafin in a patient with impetigo herpetiformis. ( 9274639 )
1997
49
Impetigo herpetiformis and Staphylococcus aureus lymphadenitis in a pregnant adolescent. ( 9336813 )
1997
50
Twins with impetigo herpetiformis. ( 8850053 )
1996

Variations for Impetigo Herpetiformis

Expression for Impetigo Herpetiformis

Search GEO for disease gene expression data for Impetigo Herpetiformis.

Pathways for Impetigo Herpetiformis

Pathways related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 ELANE PI3 PRTN3
2
Show member pathways
11.38 IL1RL2 IL36RN TNF
3 9.97 NLRP1 TNF

GO Terms for Impetigo Herpetiformis

Cellular components related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB ELANE IL36RN PRTN3 PTH SERPINB1
2 extracellular region GO:0005576 9.23 ALB ELANE IL36RN PI3 PRTN3 PTH

Biological processes related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 IL1RL2 IL36RN NLRP1 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.56 IL1RL2 IL36RN PRTN3 TNF
3 negative regulation of interleukin-6 production GO:0032715 9.43 IL36RN TNF
4 negative regulation of growth of symbiont in host GO:0044130 9.4 ELANE TNF
5 regulation of inflammatory response GO:0050727 9.33 IL1RL2 NLRP1 TNF
6 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.32 ELANE TNF
7 positive regulation of interleukin-6 production GO:0032755 9.13 IL1RL2 IL36RN TNF
8 antimicrobial humoral response GO:0019730 8.8 ELANE PI3 PRTN3

Sources for Impetigo Herpetiformis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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