MCID: IMP001
MIFTS: 28

Impetigo Herpetiformis

Categories: Skin diseases

Aliases & Classifications for Impetigo Herpetiformis

MalaCards integrated aliases for Impetigo Herpetiformis:

Name: Impetigo Herpetiformis 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:8503
ICD9CM 34 694.3
SNOMED-CT 67 200973000
ICD10 32 L40.1
UMLS 70 C1314968

Summaries for Impetigo Herpetiformis

Disease Ontology : 12 An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy.

MalaCards based summary : Impetigo Herpetiformis is related to pustular psoriasis and impetigo. An important gene associated with Impetigo Herpetiformis is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Defensins and C-MYB transcription factor network. Affiliated tissues include skin and thyroid, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Impetigo herpetiformis is a form of severe pustular psoriasis occurring in pregnancy which may occur... more...

Related Diseases for Impetigo Herpetiformis

Diseases related to Impetigo Herpetiformis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 pustular psoriasis 31.7 PI3 IL36RN ELANE
2 impetigo 30.6 SERPINB1 PRTN3 PI3 IL36RN ELANE
3 pustulosis of palm and sole 30.4 IL36RN IL1RL2 CARD14
4 psoriasis 14, pustular 30.3 IL36RN IL1RL2 CARD14
5 psoriasis 30.0 PI3 IL36RN ELANE CARD14
6 skin disease 29.6 PRTN3 PI3 IL36RN CARD14
7 hypoparathyroidism 10.5
8 acrodermatitis 10.4
9 pemphigus 10.4
10 dermatitis herpetiformis, familial 10.4
11 dermatitis 10.4
12 placental insufficiency 10.4
13 dermatitis herpetiformis 10.4
14 pemphigus vegetans 10.3
15 exanthem 10.2
16 geographic tongue 10.1 IL36RN IL1RL2
17 atrophic glossitis 10.1 IL36RN IL1RL2
18 pulmonary hemosiderosis 10.1 PRTN3 IL36RN
19 deep keratitis 10.0 PRTN3 PI3
20 periostitis 10.0 IL36RN IL1RL2
21 neutrophilic dermatosis, acute febrile 10.0 IL36RN IL1RL2
22 mycosis fungoides 10.0
23 intrahepatic cholestasis of pregnancy 10.0
24 dermatomyositis 10.0
25 bacterial infectious disease 10.0
26 rickets 10.0
27 hyperparathyroidism 10.0
28 cholestasis 10.0
29 lymphadenitis 10.0
30 ichthyosis 10.0
31 systemic scleroderma 10.0
32 subacute delirium 10.0
33 pustulosis palmaris et plantaris 10.0 IL36RN ELANE
34 farmer's lung 10.0 PI3 ELANE
35 pasteurellosis 10.0 PI3 ELANE
36 erysipelas 9.9 PI3 ELANE
37 autoimmune vasculitis 9.9 PRTN3 ELANE
38 netherton syndrome 9.9 PI3 ELANE
39 rapidly progressive glomerulonephritis 9.9 PRTN3 ELANE
40 pulmonary emphysema 9.9 SERPINB1 ELANE
41 papillon-lefevre syndrome 9.9 PRTN3 ELANE
42 extrinsic allergic alveolitis 9.9 PI3 ELANE
43 miliaria pustulosa 9.8 IL1RL2 CARD14
44 bronchitis 9.8 SERPINB1 ELANE
45 familial cold autoinflammatory syndrome 2 9.8 IL1RL2 CARD14
46 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 9.8 IL1RL2 CARD14
47 cholangitis, primary sclerosing 9.7 PRTN3 ELANE
48 mevalonic aciduria 9.7 IL1RL2 CARD14
49 plasma protein metabolism disease 9.7 SERPINB1 PRTN3 ELANE
50 alpha-1-antitrypsin deficiency 9.7 SERPINB1 PRTN3 ELANE

Graphical network of the top 20 diseases related to Impetigo Herpetiformis:



Diseases related to Impetigo Herpetiformis

Symptoms & Phenotypes for Impetigo Herpetiformis

MGI Mouse Phenotypes related to Impetigo Herpetiformis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CARD14 ELANE IL1RL2 IL36RN PRTN3 SERPINB1
2 immune system MP:0005387 9.1 CARD14 ELANE IL1RL2 IL36RN PRTN3 SERPINB1

Drugs & Therapeutics for Impetigo Herpetiformis

Search Clinical Trials , NIH Clinical Center for Impetigo Herpetiformis

Genetic Tests for Impetigo Herpetiformis

Anatomical Context for Impetigo Herpetiformis

MalaCards organs/tissues related to Impetigo Herpetiformis:

40
Skin, Thyroid

Publications for Impetigo Herpetiformis

Articles related to Impetigo Herpetiformis:

(show top 50) (show all 181)
# Title Authors PMID Year
1
Significance of IL36RN mutation analyses in the management of impetigo herpetiformis: A case report and review of published cases. 61
33599999 2021
2
Efficacy and safety of treatment with anti-tumor necrosis factor-α drugs for severe impetigo herpetiformis. 61
33035362 2021
3
[PUSTULAR PSORIASIS DURING PREGNANCY: WHEN IS THE RIGHT TIME TO DELIVER?] 61
33210847 2020
4
A case of impetigo herpetiformis in which termination of pregnancy was required. 61
32643981 2020
5
Infliximab for the treatment of recalcitrant generalized pustular psoriasis of pregnancy: Report of a challenging case. 61
32406109 2020
6
Impetigo herpetiformis with a CARD14 Thr79Ile variant successfully treated with granulocyte and monocyte adsorption apheresis. 61
31971270 2020
7
Impetigo herpetiformis responsive to secukinumab. 61
31361940 2019
8
Treatment resistant impetigo herpetiformis treated with infliximab. 61
30693621 2019
9
An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up. 61
30028004 2019
10
Generalized pustular psoriasis: a review and update on treatment. 61
29573491 2018
11
Granulocyte/Monocyte Adsorption Apheresis as a Novel Therapeutic Approach in the Treatment of an Impetigo Herpetiformis Case. 61
29318775 2018
12
Impetigo herpetiformis with IL-36RN mutation successfully treated with secukinumab. 61
30105995 2018
13
Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin. 61
29422292 2018
14
A case of pustular psoriasis of pregnancy with positive maternal-fetal outcomes. 61
29763478 2018
15
Impetigo Herpetiformis: Review of Pathogenesis, Complication, and Treatment. 61
29849579 2018
16
Impetigo herpetiformis: a rare dermotosis of pregnancy. 61
30637058 2018
17
[Impetigo herpetiformis]. 61
30657292 2017
18
Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. 61
27573023 2017
19
Recurrent impetigo herpetiformis: case report. 61
28979621 2017
20
Oral and vulvovaginal changes in pregnancy. 61
27265073 2016
21
Inflammatory and glandular skin disease in pregnancy. 61
27265071 2016
22
Skin disease in pregnancy: The approach of the obstetric medicine physician. 61
27265069 2016
23
Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis. 61
25413895 2016
24
Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. 61
26104679 2015
25
[Pregnancy-specific dermatoses]. 61
25194221 2015
26
Case report of a rare dermatosis in pregnancy: impetigo herpetiformis. 61
25303404 2015
27
Psoriasis in pregnancy: challenges and solutions. 61
29387585 2015
28
IL36RN mutations underlie impetigo herpetiformis. 61
24717243 2014
29
Pustular psoriasis of pregnancy (impetigo herpetiformis)--case report. 61
24346915 2013
30
Anesthetic management for cesarean delivery of a parturient with impetigo herpetiformis. 61
25611605 2013
31
Cyclosporine in the management of impetigo herpetiformis: a case report and review of the literature. 61
23626548 2013
32
Recurrent postpartum impetigo herpetiformis presenting after a "skip" pregnancy. 61
22854922 2013
33
Impetigo Herpetiformis during pregnancy: a case report and literature review. 61
23446290 2013
34
[What's new in dermatology?]. 61
23316658 2012
35
A case of recurrent impetigo herpetiformis treated with systemic corticosteroids and narrowband UVB. 61
22264139 2012
36
Shape and configuration of skin lesions: grouped herpetiform. 61
21855726 2011
37
[Pustular eruption of pregnancy: Impetigo herpetiformis]. 61
21334846 2011
38
Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report. 61
21159049 2011
39
First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. 61
22696729 2011
40
Pregnancy dermatoses: diagnosis, management, and controversies. 61
21110524 2011
41
Impetigo herpetiformis with gestational hypertension: a case report and literature review. 61
21494028 2011
42
Ritodrine-induced pustular eruptions distinctly resembling impetigo herpetiformis. 61
22041881 2011
43
[Chronic inflammatory and autoimmune mediated dermatoses during pregnancy. Course and prognosis for mother and child]. 61
21076804 2010
44
Recurrent impetigo herpetiformis with diabetes and hypoalbuminemia successfully treated with cyclosporine, albumin, insulin and metformin. 61
20606891 2010
45
Treatment of psoriasis with anti-TNF drugs during pregnancy: case report and review of the literature. 61
19940453 2010
46
Impetigo herpetiformis during the puerperium triggered by secondary hypoparathyroidism: a case report. 61
20072676 2009
47
Impetigo herpetiformis: a rare dermatosis of pregnancy. 61
19864978 2009
48
Impetigo herpetiformis with postpartum flare-up: a case report. 61
19588063 2009
49
Postpartum impetigo herpetiformis complicated with hypovolaemic shock. 61
19521302 2009
50
Recurrent impetigo herpetiformis successfully treated with methotrexate. 61
18554218 2009

Variations for Impetigo Herpetiformis

Expression for Impetigo Herpetiformis

Search GEO for disease gene expression data for Impetigo Herpetiformis.

Pathways for Impetigo Herpetiformis

Pathways related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 PRTN3 PI3 ELANE
2 10.85 PRTN3 ELANE

GO Terms for Impetigo Herpetiformis

Cellular components related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 SERPINB1 PRTN3 PI3 IL36RN ELANE
2 azurophil granule lumen GO:0035578 9.26 PRTN3 ELANE
3 collagen-containing extracellular matrix GO:0062023 9.13 SERPINB1 PRTN3 ELANE
4 extracellular space GO:0005615 9.02 SERPINB1 PRTN3 PI3 IL36RN ELANE

Biological processes related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.5 PI3 IL36RN IL1RL2
2 neutrophil degranulation GO:0043312 9.43 SERPINB1 PRTN3 ELANE
3 negative regulation of peptidase activity GO:0010466 9.37 SERPINB1 PI3
4 phagocytosis GO:0006909 9.16 PRTN3 ELANE
5 cytokine-mediated signaling pathway GO:0019221 9.13 PRTN3 IL36RN IL1RL2
6 antimicrobial humoral response GO:0019730 8.8 PRTN3 PI3 ELANE

Molecular functions related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 8.96 SERPINB1 PI3
2 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINB1 PI3

Sources for Impetigo Herpetiformis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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