MCID: IMP001
MIFTS: 27

Impetigo Herpetiformis

Categories: Skin diseases

Aliases & Classifications for Impetigo Herpetiformis

MalaCards integrated aliases for Impetigo Herpetiformis:

Name: Impetigo Herpetiformis 12 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8503
ICD9CM 34 694.3
SNOMED-CT 67 65539006
ICD10 32 L40.1
UMLS 71 C1314968

Summaries for Impetigo Herpetiformis

Disease Ontology : 12 An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy.

MalaCards based summary : Impetigo Herpetiformis is related to pustular psoriasis and psoriasis 14, pustular. An important gene associated with Impetigo Herpetiformis is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and Defensins. Affiliated tissues include skin, monocytes and thyroid, and related phenotype is immune system.

Wikipedia : 74 Impetigo herpetiformis is a form of severe pustular psoriasis occurring in pregnancy which may occur... more...

Related Diseases for Impetigo Herpetiformis

Diseases related to Impetigo Herpetiformis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 pustular psoriasis 32.0 PI3 IL36RN ELANE AP1S3
2 psoriasis 14, pustular 31.1 IL36RN AP1S3
3 impetigo 30.6 SERPINB1 PRTN3 PI3 IL36RN ELANE
4 skin disease 30.0 PI3 IL36RN CARD14
5 pustulosis of palm and sole 29.9 IL36RN IL1RL2 CARD14 AP1S3
6 psoriasis 29.3 SERPINB1 PI3 IL36RN ELANE CARD14 AP1S3
7 acrodermatitis 29.3 IL36RN IL1RL2 CARD14 AP1S3
8 hypoparathyroidism 10.6
9 placental insufficiency 10.5
10 dermatitis 10.4
11 dermatitis herpetiformis, familial 10.4
12 dermatitis herpetiformis 10.4
13 pemphigus 10.4
14 exanthem 10.3
15 pemphigus vegetans 10.3
16 pulmonary hemosiderosis 10.1 PRTN3 IL36RN
17 mycosis fungoides 10.1
18 intrahepatic cholestasis of pregnancy 10.1
19 dermatomyositis 10.1
20 bacterial infectious disease 10.1
21 rickets 10.1
22 hyperparathyroidism 10.1
23 cholestasis 10.1
24 lymphadenitis 10.1
25 ichthyosis 10.1
26 systemic scleroderma 10.1
27 subacute delirium 10.1
28 lupus erythematosus 10.1
29 farmer's lung 10.0 PI3 ELANE
30 pasteurellosis 10.0 PI3 ELANE
31 erysipelas 10.0 PI3 ELANE
32 autoimmune vasculitis 10.0 PRTN3 ELANE
33 bronchopneumonia 10.0 PI3 ELANE
34 felty syndrome 10.0 PRTN3 ELANE
35 rapidly progressive glomerulonephritis 9.9 PRTN3 ELANE
36 netherton syndrome 9.9 PI3 ELANE
37 psoriasis 15 9.9 ELANE AP1S3
38 papillon-lefevre syndrome 9.9 PRTN3 ELANE
39 pulmonary emphysema 9.9 SERPINB1 ELANE
40 extrinsic allergic alveolitis 9.9 PI3 ELANE
41 atrophic glossitis 9.9 IL36RN IL1RL2
42 inguinal hernia 9.9 SERPINB1 ELANE
43 plasma protein metabolism disease 9.8 SERPINB1 PRTN3 ELANE
44 alpha-1-antitrypsin deficiency 9.7 SERPINB1 PRTN3 ELANE
45 cholangitis, primary sclerosing 9.7 PRTN3 ELANE
46 granulomatosis with polyangiitis 9.7 SERPINB1 PRTN3 ELANE
47 pustulosis palmaris et plantaris 9.7 IL36RN ELANE AP1S3
48 vasculitis 9.7 SERPINB1 PRTN3 ELANE
49 familial cold autoinflammatory syndrome 2 9.6 IL1RL2 CARD14
50 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 9.6 IL1RL2 CARD14

Graphical network of the top 20 diseases related to Impetigo Herpetiformis:



Diseases related to Impetigo Herpetiformis

Symptoms & Phenotypes for Impetigo Herpetiformis

MGI Mouse Phenotypes related to Impetigo Herpetiformis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CARD14 ELANE IL1RL2 IL36RN PRTN3 SERPINB1

Drugs & Therapeutics for Impetigo Herpetiformis

Search Clinical Trials , NIH Clinical Center for Impetigo Herpetiformis

Genetic Tests for Impetigo Herpetiformis

Anatomical Context for Impetigo Herpetiformis

MalaCards organs/tissues related to Impetigo Herpetiformis:

40
Skin, Monocytes, Thyroid

Publications for Impetigo Herpetiformis

Articles related to Impetigo Herpetiformis:

(show top 50) (show all 171)
# Title Authors PMID Year
1
Infliximab for the treatment of recalcitrant generalized pustular psoriasis of pregnancy: Report of a challenging case. 61
32406109 2020
2
Impetigo herpetiformis with a CARD14 Thr79Ile variant successfully treated with granulocyte and monocyte adsorption apheresis. 61
31971270 2020
3
Impetigo herpetiformis responsive to secukinumab. 61
31361940 2019
4
Treatment resistant impetigo herpetiformis treated with infliximab. 61
30693621 2019
5
An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up. 61
30028004 2019
6
Generalized pustular psoriasis: a review and update on treatment. 61
29573491 2018
7
Granulocyte/Monocyte Adsorption Apheresis as a Novel Therapeutic Approach in the Treatment of an Impetigo Herpetiformis Case. 61
29318775 2018
8
Impetigo herpetiformis with IL-36RN mutation successfully treated with secukinumab. 61
30105995 2018
9
Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin. 61
29422292 2018
10
A case of pustular psoriasis of pregnancy with positive maternal-fetal outcomes. 61
29763478 2018
11
Impetigo Herpetiformis: Review of Pathogenesis, Complication, and Treatment. 61
29849579 2018
12
Impetigo herpetiformis: a rare dermotosis of pregnancy. 61
30637058 2018
13
[Impetigo herpetiformis]. 61
30657292 2017
14
Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. 61
27573023 2017
15
Recurrent impetigo herpetiformis: case report. 61
28979621 2017
16
Oral and vulvovaginal changes in pregnancy. 61
27265073 2016
17
Inflammatory and glandular skin disease in pregnancy. 61
27265071 2016
18
Skin disease in pregnancy: The approach of the obstetric medicine physician. 61
27265069 2016
19
Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis. 61
25413895 2016
20
Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. 61
26104679 2015
21
[Pregnancy-specific dermatoses]. 61
25194221 2015
22
Case report of a rare dermatosis in pregnancy: impetigo herpetiformis. 61
25303404 2015
23
Psoriasis in pregnancy: challenges and solutions. 61
29387585 2015
24
IL36RN mutations underlie impetigo herpetiformis. 61
24717243 2014
25
Pustular psoriasis of pregnancy (impetigo herpetiformis)--case report. 61
24346915 2013
26
Anesthetic management for cesarean delivery of a parturient with impetigo herpetiformis. 61
25611605 2013
27
Impetigo Herpetiformis during pregnancy: a case report and literature review. 61
23446290 2013
28
Recurrent postpartum impetigo herpetiformis presenting after a "skip" pregnancy. 61
22854922 2013
29
Cyclosporine in the management of impetigo herpetiformis: a case report and review of the literature. 61
23626548 2013
30
[What's new in dermatology?]. 61
23316658 2012
31
A case of recurrent impetigo herpetiformis treated with systemic corticosteroids and narrowband UVB. 61
22264139 2012
32
Shape and configuration of skin lesions: grouped herpetiform. 61
21855726 2011
33
[Pustular eruption of pregnancy: Impetigo herpetiformis]. 61
21334846 2011
34
Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report. 61
21159049 2011
35
First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. 61
22696729 2011
36
Pregnancy dermatoses: diagnosis, management, and controversies. 61
21110524 2011
37
Impetigo herpetiformis with gestational hypertension: a case report and literature review. 61
21494028 2011
38
Ritodrine-induced pustular eruptions distinctly resembling impetigo herpetiformis. 61
22041881 2011
39
[Chronic inflammatory and autoimmune mediated dermatoses during pregnancy. Course and prognosis for mother and child]. 61
21076804 2010
40
Recurrent impetigo herpetiformis with diabetes and hypoalbuminemia successfully treated with cyclosporine, albumin, insulin and metformin. 61
20606891 2010
41
Treatment of psoriasis with anti-TNF drugs during pregnancy: case report and review of the literature. 61
19940453 2010
42
Impetigo herpetiformis during the puerperium triggered by secondary hypoparathyroidism: a case report. 61
20072676 2009
43
Impetigo herpetiformis: a rare dermatosis of pregnancy. 61
19864978 2009
44
Impetigo herpetiformis with postpartum flare-up: a case report. 61
19588063 2009
45
Postpartum impetigo herpetiformis complicated with hypovolaemic shock. 61
19521302 2009
46
Recurrent impetigo herpetiformis successfully treated with methotrexate. 61
18554218 2009
47
[Impetigo herpetiformis (two cases)]. 61
18657371 2008
48
Impetigo herpetiformis occurring during N-butyl-scopolammonium bromide therapy in pregnancy: case report. 61
18597707 2008
49
An update on the dermatoses of pregnancy. 61
18390233 2008
50
[How I explore...pruritus in a pregnant woman]. 61
18286948 2007

Variations for Impetigo Herpetiformis

Expression for Impetigo Herpetiformis

Search GEO for disease gene expression data for Impetigo Herpetiformis.

Pathways for Impetigo Herpetiformis

Pathways related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 SERPINB1 PRTN3 PI3 IL1RL2 ELANE AP1S3
2
Show member pathways
11.13 PRTN3 PI3 ELANE
3 11.05 PRTN3 ELANE

GO Terms for Impetigo Herpetiformis

Cellular components related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 SERPINB1 PRTN3 PI3 IL36RN ELANE
2 azurophil granule lumen GO:0035578 9.16 PRTN3 ELANE
3 collagen-containing extracellular matrix GO:0062023 9.13 SERPINB1 PRTN3 ELANE
4 extracellular space GO:0005615 9.02 SERPINB1 PRTN3 PI3 IL36RN ELANE

Biological processes related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.43 SERPINB1 PRTN3 ELANE
2 phagocytosis GO:0006909 9.16 PRTN3 ELANE
3 cytokine-mediated signaling pathway GO:0019221 9.13 PRTN3 IL36RN IL1RL2
4 antimicrobial humoral response GO:0019730 8.8 PRTN3 PI3 ELANE

Molecular functions related to Impetigo Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINB1 PI3

Sources for Impetigo Herpetiformis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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