Aliases & Classifications for Impotence

MalaCards integrated aliases for Impotence:

Name: Impotence 12 29 55 15
Erectile Dysfunction 12 55 43 15 73
Erectile Dysfunction Adverse Event 73
Sexual Impotence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1875

Summaries for Impotence

MedlinePlus : 43 Erectile dysfunction (ED) is a common type of male sexual dysfunction. It is when a man has trouble getting or keeping an erection. ED becomes more common as you get older. But it's not a natural part of aging. Some people have trouble speaking with their doctors about sex. But if you have ED, you should tell your doctor. ED can be a sign of health problems. It may mean your blood vessels are clogged. It may mean you have nerve damage from diabetes. If you don't see your doctor, these problems will go untreated. Your doctor can offer several new treatments for ED. For many men, the answer is as simple as taking a pill. Getting more exercise, losing weight, or stopping smoking may also help. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Impotence, also known as erectile dysfunction, is related to vasculogenic impotence and peyronie disease, and has symptoms including tremor, angina pectoris and pelvic pain. An important gene associated with Impotence is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Platelet homeostasis. The drugs Testosterone and Testosterone enanthate have been mentioned in the context of this disorder. Affiliated tissues include prostate, endothelial and spinal cord, and related phenotypes are normal and reproductive system

Wikipedia : 76 Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the... more...

Related Diseases for Impotence

Diseases related to Impotence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 vasculogenic impotence 33.6 ALDH7A1 NOS3 PDE5A
2 peyronie disease 32.4 NOS2 PDE5A
3 prostatic adenoma 30.8 KLK3 SRD5A1
4 ischemic optic neuropathy 30.6 EDN1 NOS3 PDE5A
5 nonarteritic anterior ischemic optic neuropathy 30.6 EDN1 NOS3 PDE5A
6 arteries, anomalies of 30.6 EDN1 KNG1 NOS3
7 coronary artery anomaly 30.5 EDN1 KNG1 NOS3
8 hyperprolactinemia 30.4 PRL SHBG VIP
9 gynecomastia 30.3 KLK3 PRL SHBG
10 vascular disease 29.9 EDN1 KNG1 NOS2 NOS3
11 varicocele 29.9 NOS2 NOS3 PRL SHBG
12 androgenic alopecia 29.9 KLK3 PRL SHBG
13 ischemia 29.9 EDN1 KNG1 NOS1 NOS2 NOS3
14 hypertension, essential 29.8 EDN1 KNG1 NOS2 NOS3
15 rhinitis 29.7 CYP3A4 KNG1 VIP
16 alopecia, androgenetic, 1 29.6 SHBG SRD5A1
17 prostatic hyperplasia, benign 29.5 KLK3 PDE5A SHBG SRD5A1
18 pulmonary hypertension 29.5 EDN1 NOS2 NOS3 PDE5A VIP
19 sexual disorder 29.1 ALDH7A1 EDN1 KCNMA1 KLK3 NOS1 NOS3
20 multiple system atrophy 1 11.4
21 autonomic nervous system disease 11.4
22 diabetic neuropathy 11.4
23 pituitary adenoma 4, acth-secreting 11.1
24 paroxysmal nocturnal hemoglobinuria 1 11.1
25 microvascular complications of diabetes 1 11.1
26 tabes dorsalis 11.1
27 kallmann syndrome 11.1
28 pure autonomic failure 11.1
29 amyloidosis, hereditary, transthyretin-related 11.0
30 neuropathy, hereditary sensory and autonomic, type iii 11.0
31 empty sella syndrome 11.0
32 tarlov cysts 11.0
33 dysautonomia 11.0
34 diabetes mellitus, noninsulin-dependent 10.4
35 sleep apnea 10.4
36 peyronie's disease 10.3
37 heart disease 10.3
38 optic nerve disease 10.3
39 gout 10.3
40 prostatitis 10.3
41 hypogonadotropism 10.3
42 prostate cancer 10.3
43 myocardial infarction 10.2
44 periodontitis 10.2
45 cluster headache 10.2 NOS1 PRL VIP
46 atrial fibrillation 10.2
47 melanoma 10.2
48 psoriasis 10.2
49 platelet membrane fluidity 10.2 NOS2 NOS3
50 aging 10.2

Graphical network of the top 20 diseases related to Impotence:



Diseases related to Impotence

Symptoms & Phenotypes for Impotence

UMLS symptoms related to Impotence:


tremor, angina pectoris, pelvic pain, equilibration disorder, symptom/complaint potency (excluding p07 p08), inability to maintain erection, unable to perform sex

MGI Mouse Phenotypes related to Impotence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.56 ALDH7A1 EDN1 NOS1 NOS3 PDE3A SEPT3
2 reproductive system MP:0005389 9.23 KCNMA1 NOS1 NOS2 NOS3 PDE3A PRL

Drugs & Therapeutics for Impotence

Drugs for Impotence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 333)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-22-0 6013
2
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 315-37-7 9416
3
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 5949-44-0
4
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-18-4 6010
5 tannic acid Approved Phase 4,Phase 3
6
Benzocaine Approved, Investigational Phase 4,Phase 3 94-09-7, 1994-09-7 2337
7
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 171596-29-5 110635
8
Nebivolol Approved, Investigational Phase 4,Not Applicable 99200-09-6, 152520-56-4, 118457-14-0 71301
9
Fenofibrate Approved Phase 4,Phase 3 49562-28-9 3339
10
Felodipine Approved, Investigational Phase 4 72509-76-3 3333
11
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
12
Metoprolol Approved, Investigational Phase 4,Phase 3,Not Applicable 37350-58-6, 51384-51-1 4171
13
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
14
Dutasteride Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 164656-23-9 6918296 152945
15
Tamsulosin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 106133-20-4 129211
16
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 745-65-3 149351 5280723
17
Nitric Oxide Approved Phase 4 10102-43-9 145068
18
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
19
Zinc Approved, Investigational Phase 4 7440-66-6
20
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
21
Allantoin Approved Phase 4 97-59-6 204
22
Yohimbine Approved, Investigational, Vet_approved Phase 4 146-48-5 8969
23
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3 58-93-5 3639
24
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
25
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
26
Magnesium oxide Approved Phase 4 1309-48-4 14792
27
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
28
Nadolol Approved Phase 4 42200-33-9 39147
29
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
30
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
31
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
32
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
33
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
34
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
35
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
36
Polyestradiol phosphate Approved Phase 4,Phase 1 28014-46-2
37
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1 50-28-2 5757
38 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 1 979-32-8
39
Rosiglitazone Approved, Investigational Phase 4,Phase 1 122320-73-4 77999
40
Selegiline Approved, Investigational, Vet_approved Phase 4 14611-51-9 26757 5195
41
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
42 Orange Approved Phase 4
43
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 77-92-9 311
44
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 1406-16-2
45
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
46
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
47
Udenafil Investigational Phase 4,Phase 3,Phase 2,Phase 1 268203-93-6 6918523
48
Candesartan Experimental Phase 4 139481-59-7 2541
49
2,4-thiazolidinedione Investigational Phase 4 2295-31-0
50 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 630)
# Name Status NCT ID Phase Drugs
1 Treatment of Erectile Dysfunction in Hypogonadal Men With Testosterone Undecanoate Unknown status NCT00555087 Phase 4 Testosterone Undecanoate and/or PDE-5
2 A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4 Vardenafil;Placebo
3 Effect of Tadalafil on Erectile Dysfunction Treatment and QOL Improvement Effect (by SF-12) in Andropause Patients With Erectile Dysfunction Unknown status NCT02943356 Phase 4 Tadalafil
4 Effect of Vardenafil on Erectile Dysfunction and Portal Hemodynamics in Patients With Liver Cirrhosis Unknown status NCT02344823 Phase 4 Vardenafil;Placebo intake once daily
5 Nebivolol Effects on Endothelial Function and Erectile Function Unknown status NCT01885988 Phase 4 Nebivolol;Sugar Pill
6 Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer Unknown status NCT00906269 Phase 4 Sildenafil therapy plus post-NSRRP HBO2T;Sildenafil therapy plus sham post-NSRRP HBO2T
7 Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i Unknown status NCT00498680 Phase 4 Sildenafil, Vardenafil;Sildenafil;Vardenafil;Sildenafil & Vardenafil
8 Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment Unknown status NCT01364701 Phase 4 Sildenafil 100 mg;Tadalafil 20 mg;Combination half of maximal dose for sildenafil & tadalafil
9 Effect of Sildenafil on Quality of Sexual Life in Mild to Normally Sexually Functioning Males Unknown status NCT00313898 Phase 4 sildenafil (viagra)
10 Nerve Grafting With an Allograft During Radical Prostatectomy - Extended Follow-up in a Prospective Randomized Trial Unknown status NCT01770340 Phase 4
11 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4 Testosterone
12 Treatment of Hyperlipidemia and Sexual Dysfunction Unknown status NCT00923676 Phase 4 fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
13 Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status NCT01238705 Phase 4 Felodipine add Irbesartan;Felodipine add Metoprolol
14 A Study in Patients With Erectile Dysfunction Completed NCT01122264 Phase 4 Tadalafil;Sildenafil Citrate
15 Impact Of Viagra On Sexual Satisfaction Of Men With Mild Erectile Dysfunction Who Are Sexually Dissatisfied Completed NCT00301262 Phase 4 Viagra (Sildenafil citrate)
16 Evaluation of LEVITRA to Advance the Treatment of Erectile Dysfunction Completed NCT00664833 Phase 4
17 L-Arginine and Erectile Dysfunction Completed NCT00777075 Phase 4 L-arginine;Placebo
18 Effect of Tadalafil on the Quality of Life and Sexual Life in Erectile Dysfunction Completed NCT00422578 Phase 4 tadalafil
19 Investigate the Responsiveness of the Erectile Quality Scale to Vardenafil Flexible Dose vs Placebo in Males With Erectile Dysfunction (ED) Completed NCT00665340 Phase 4 Placebo;Levitra (Vardenafil, BAY38-9456)
20 Vardenafil and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) Completed NCT02450188 Phase 4 Vardenafil
21 Evaluating of the Efficacy and Safety of Vardenafil in Subjects With Erectile Dysfunction Completed NCT00662441 Phase 4 Levitra (Vardenafil, BAY38-9456)
22 Assessing Efficacy and Safety of Flexible Dosing With Vardenafil in Subjects With Erectile Dysfunction and Hyperlipidemia Completed NCT00663845 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
23 Assessment of Vardenafil in Patients With Erectile Dysfunction in Asia Completed NCT00668135 Phase 4 Vardenafil (Levitra, BAY38-9456);Placebo
24 Evaluation of the Safety and Efficacy of Vardenafil in Subjects With Erectile Dysfunction Completed NCT00681772 Phase 4 Levitra (Vardenafil, BAY38-9456)
25 Satisfaction, Confidence and Naturalness in Men With Psychogenic Erectile Dysfunction (ED) Completed NCT01153204 Phase 4 Sildenafil citrate
26 Mild To Moderate Erectile Dysfunction Study Completed NCT00137072 Phase 4 Viagra (Sildenafil Citrate) 100 mg
27 Efficacy and Safety of Lodenafil Carbonate in the Treatment of Erectile Dysfunction in Patients With Diabetes. Completed NCT01180283 Phase 4 lodenafil carbonate
28 Study Of Men With Mild To Moderate Erectile Dysfunction To Evaluate The Efficacy Of Viagra 8 Hours Post-Dose Completed NCT00143260 Phase 4 Viagra (Sildenafil Citrate) 100 mg
29 BAY38-9456, 5/10/20mg, vs.Placebo in Erectile Dysfunction Completed NCT00665054 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
30 A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China Completed NCT01352507 Phase 4 Tadalafil;Sildenafil
31 Use of Sildenafil (Viagra) in Diabetic Men With Erectile Dysfunction: the Impact on Blood Vessels Completed NCT00199563 Phase 4 Viagra
32 Evaluation of Efficacy and Safety of Vardenafil in Patients With Erectile Dysfunction and Type 1 Diabetes Completed NCT00660998 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
33 Study of Vardenafil in Patients Suffering From Erectile Dysfunction and Metabolic Syndrome Completed NCT00738400 Phase 4 Vardenafil (Levitra, BAY38-9456);Placebo
34 A Safety and Efficacy Study of Prograf in the Prevention of Erectile Dysfunction After Radical Prostatectomy Completed NCT00106392 Phase 4 Tacrolimus;Placebo
35 The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4 Testosterone Undecanoate,1000mg
36 A Study Evaluating Vardenafil Compared to Placebo in Subjects With Erectile Dysfunction (ED) and Dyslipidemia Completed NCT00379756 Phase 4 LEVITRA (vardenafil);placebo
37 Research Evaluating a PDE5 Inhibitor for Erectile Dysfunction Completed NCT01698684 Phase 4 Placebo;Avanafil 100 mg;Avanafil 200 mg
38 A Study of Tadalafil (LY450190) in Chinese Men With Erectile Dysfunction Completed NCT02224846 Phase 4 Tadalafil
39 QEQ Treatment Responsiveness Evaluation Study Completed NCT00151463 Phase 4 sildenafil citrate
40 Quality of Erection Study Completed NCT00159900 Phase 4 Sildenafil Citrate
41 Evaluating the Efficacy Vardenafil 10 mg vs Tadalafil 10 mg in in Subjects With Erectile Dysfunction (ED) Completed NCT00663130 Phase 4 Levitra (Vardenafil, BAY38-9456);Tadalafil
42 A Multicenter, Randomized, Parallel Group, Double-Blind, Placebo Controlled, Flexible Dose Escalation Study To Evaluate Sexual And Relationship Satisfaction In The Female Partner Of Men With Erectile Dysfunction Treated With Sildenafil Citrate Completed NCT00644631 Phase 4 sildenafil;placebo
43 Effect of Testosterone in Men With Erectile Dysfunction Completed NCT00512707 Phase 4 Sildenafil citrate (open label);Testosterone gel
44 A Multicenter, Open Label, To Evaluate The Efficacy And Satisfaction Of Patrex® In Men With Erectile Dysfunction. Completed NCT00468650 Phase 4 sildenafil citrate
45 Effects of Sildenafil on Penile Vascular Function in Hypertensive Men With Erectile Dysfunction Completed NCT02620995 Phase 4 sildenafil citrate
46 A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil Completed NCT00644956 Phase 4 tadalafil;sildenafil
47 A Study Of The Safety and Efficacy Of Viagra In Men With Erectile Dysfunction Who Do Not Self Identify. Completed NCT00343200 Phase 4 Placebo;Viagra (sildenafil citrate)
48 Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients Completed NCT01468519 Phase 4 Insulin;Insulin
49 Efficacy Study Measuring The Impact Of Treatment With Viagra On The Depressive Symptoms Of Men With Erectile Dysfunction Completed NCT00159809 Phase 4 Viagra (Sildenafil citrate)
50 A Study Evaluating the Efficacy and Safety of Sildenafil in Patients With Erectile Dysfunction Receiving Hemodialysis Completed NCT00654017 Phase 4 placebo;sildenafil

Search NIH Clinical Center for Impotence

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Impotence

Genetic tests related to Impotence:

# Genetic test Affiliating Genes
1 Impotence 29

Anatomical Context for Impotence

MalaCards organs/tissues related to Impotence:

41
Prostate, Endothelial, Spinal Cord, Kidney, Bone, Testes, Heart

Publications for Impotence

Articles related to Impotence:

(show top 50) (show all 2622)
# Title Authors Year
1
Newly Diagnosed Bipolar Disorder and the Subsequent Risk of Erectile Dysfunction: A Nationwide Cohort Study. ( 29425665 )
2018
2
Large Solitary Plexiform Neurofibroma of the Penis Without Erectile Dysfunction: a Case Report from Kerala. ( 29581693 )
2018
3
A case of pheochromocytoma with negative MIBG scintigraphy, PET-CT and genetic tests (VHL included) and a rare case of post-operative erectile dysfunction. ( 29860716 )
2018
4
Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta-analysis. ( 29341503 )
2018
5
Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction. ( 29405168 )
2018
6
The relationship between penile deformity, age, psychological bother, and erectile dysfunction in a sample of men with Peyronie's Disease (PD). ( 29795530 )
2018
7
Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study. ( 29344879 )
2018
8
Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension. ( 29368385 )
2018
9
A Novel Noninvasive Ultrasound Vibro-elastography Technique for Assessing Patients With Erectile Dysfunction and Peyronie Disease. ( 29548864 )
2018
10
Malleable Penile Implant Is an Effective Therapeutic Option in Men With Peyronie's Disease and Erectile Dysfunction. ( 29336942 )
2018
11
Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors. ( 29442076 )
2018
12
Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia. ( 30209896 )
2018
13
Erectile dysfunction among patients with chronic brucellosis. ( 30154453 )
2018
14
Frequency of Erectile Dysfunction in Males with Central Serous Chorioretinopathy. ( 28328282 )
2018
15
Chronic graft versus host disease is associated with erectile dysfunction in allogeneic hematopoietic stem cell transplant patients: a single-center experience. ( 29561209 )
2018
16
Increased Use of Medications for Erectile Dysfunction in Men With Ulcerative Colitis and Crohn's Disease Compared to Men Without Inflammatory Bowel Disease: A Nationwide Cohort Study. ( 29988041 )
2018
17
Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: Protocol for a systematic review: Erratum. ( 30383706 )
2018
18
Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: Protocol for a systematic review. ( 30290616 )
2018
19
A meta-analysis on efficacy and tolerability of sildenafil for erectile dysfunction in patients with diabetes mellitus. ( 30187018 )
2018
20
Re: Real-World Observational Results from a Database of 48 Million Men in the United States: Relationship of Cardiovascular Disease, Diabetes Mellitus and Depression with Age and Erectile Dysfunction. ( 30227549 )
2018
21
Gout and the Risk of Incident Erectile Dysfunction: A Body Mass Index-matched Population-based Study. ( 30008453 )
2018
22
Prevalence and risk factors of erectile dysfunction in patients with hepatitis B virus or hepatitis C virus or chronic liver disease: results from a prospective study. ( 30045807 )
2018
23
Homocysteine, insulin-like growth factor one and oestrogen levels in patients with erectile dysfunction-associated chronic hepatitis C virus infection. ( 30063074 )
2018
24
Frequency of Hypogonadism and Erectile Dysfunction in Type-II Diabetic Patients. ( 30034976 )
2018
25
Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study. ( 30253697 )
2018
26
The association between subclinical hypothyroidism and erectile dysfunction. ( 30034427 )
2018
27
The Magic Pill: The Branding of Impotence and the Positioning of Viagra as Its Solution through Edutainment. ( 29436964 )
2018
28
Value of flaccid penile ultrasound in screening for arteriogenic impotence: a preliminary prospective study. ( 30400881 )
2018
29
Management of Erectile Dysfunction and Infertility in the Male Spinal Cord Injury Patient. ( 29774436 )
2018
30
Evaluation of Prolidase Activity, Oxidative Stress, and Antioxidant Enzyme Levels in Testicular and Penile Tissues after Human Chorionic Gonadotropin Treatment in Rats by Predicting Infertility and Erectile Dysfunction. ( 29506009 )
2018
31
Anterior Ischemic Optic Neuropathy in a Patient with Erectile Dysfunction: Tadalafil as an Offending Medication. ( 30211242 )
2018
32
Erectile dysfunction in compensated liver cirrhosis. ( 30467076 )
2018
33
Association Between Periodontal Disease and Erectile Dysfunction: A Systematic Review. ( 27030114 )
2018
34
Chronic periodontitis is associated with erectile dysfunction. A case-control study in european population. ( 29723438 )
2018
35
Re: Extracorporeal Shock Wave Therapy (ESWT) in Urology: A Systematic Review of Outcome in Peyronie's Disease, Erectile Dysfunction, and Chronic Pelvic Pain. ( 29449032 )
2018
36
Clinical characteristics of men complaining of premature ejaculation together with erectile dysfunction: a cross-sectional study. ( 30556353 )
2018
37
Men's health 2018: BPH, prostate cancer, erectile dysfunction, supplements. ( 30395524 )
2018
38
High prevalence of erectile dysfunction in men with psoriasis: evidence from a systematic review and meta-analysis. ( 30470802 )
2018
39
Association Between Psoriasis and Sexual and Erectile Dysfunction in Epidemiologic Studies: A Systematic Review. ( 30304327 )
2018
40
Sex hormones, erectile dysfunction, and psoriasis; a bad friendship! ( 30105747 )
2018
41
Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis. ( 29735408 )
2018
42
Risk of Melanoma With Phosphodiesterase Type 5 Inhibitor Use Among Patients With Erectile Dysfunction, Pulmonary Hypertension, and Lower Urinary Tract Symptoms. ( 29884444 )
2018
43
Pelvic chondro-sarcoma and erectile dysfunction: A challenging surgical case. ( 30063021 )
2018
44
Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP). ( 30089160 )
2018
45
The Effects of Sildenafil on the Respiratory System of Patients With Obstructive Sleep Apnea and Erectile Dysfunction. ( 29734993 )
2018
46
Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis. ( 29795528 )
2018
47
R46L polymorphism in the PCSK9 gene: Relationship to lipid levels, subclinical vascular disease, and erectile dysfunction. ( 29773421 )
2018
48
Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis. ( 29891569 )
2018
49
Accurate and sensitive determination of sildenafil, tadalafil, vardenafil, and avanafil in illicit erectile dysfunction medications and human urine by LC with quadrupole-TOF-MS/MS and their behaviors in simulated gastric conditions. ( 30358113 )
2018
50
Diagnosis of erectile dysfunction can be used to improve screening for Type 2 diabetes mellitus. ( 30028534 )
2018

Variations for Impotence

Expression for Impotence

Search GEO for disease gene expression data for Impotence.

Pathways for Impotence

Pathways related to Impotence according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 KCNMA1 KNG1 NOS1 NOS2 NOS3 PDE3A
2
Show member pathways
12.01 KCNMA1 NOS1 NOS2 NOS3 PDE3A PDE5A
3 11.84 NOS1 NOS2 NOS3
4 11.69 EDN1 NOS2 NOS3
5
Show member pathways
11.44 NOS1 NOS2 NOS3
6
Show member pathways
11.31 ALDH7A1 ARG2 NOS1 NOS2 NOS3
7
Show member pathways
11.23 NOS1 NOS2 NOS3
8 11.06 NOS1 NOS2 NOS3
9
Show member pathways
11.04 ARG2 NOS1 NOS2 NOS3
10 10.96 NOS1 NOS2 NOS3
11
Show member pathways
10.72 KCNMA1 NOS1 NOS2 NOS3 PDE3A PDE5A
12 10.45 NOS1 NOS2 NOS3
13 10.37 NOS1 NOS2 NOS3 PDE5A

GO Terms for Impotence

Cellular components related to Impotence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 septin complex GO:0031105 9.32 SEPT3 SEPT6
2 septin filament array GO:0032160 9.26 SEPT3 SEPT6
3 septin ring GO:0005940 9.16 SEPT3 SEPT6
4 caveola GO:0005901 9.13 KCNMA1 NOS1 NOS3
5 vesicle membrane GO:0012506 8.8 NOS1 NOS2 NOS3

Biological processes related to Impotence according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 EDN1 PDE3A PRL SRD5A1
2 response to hypoxia GO:0001666 9.81 EDN1 KCNMA1 NOS1 NOS2
3 cell redox homeostasis GO:0045454 9.74 NOS1 NOS2 NOS3
4 response to hormone GO:0009725 9.72 NOS1 NOS2 NOS3
5 response to lipopolysaccharide GO:0032496 9.72 EDN1 NOS1 NOS2 NOS3 PRL
6 negative regulation of blood pressure GO:0045776 9.65 NOS1 NOS2 NOS3
7 regulation of sodium ion transport GO:0002028 9.63 NOS1 NOS3
8 androgen metabolic process GO:0008209 9.62 CYP3A4 SRD5A1
9 striated muscle contraction GO:0006941 9.61 ARG2 NOS1
10 negative regulation of blood coagulation GO:0030195 9.61 EDN1 KNG1
11 vasodilation GO:0042311 9.61 KNG1 NOS1 NOS3
12 septin ring assembly GO:0000921 9.6 SEPT3 SEPT6
13 negative regulation of calcium ion transport GO:0051926 9.59 NOS1 NOS3
14 body fluid secretion GO:0007589 9.58 EDN1 VIP
15 multicellular organismal response to stress GO:0033555 9.58 NOS1 PRL
16 nitric oxide mediated signal transduction GO:0007263 9.58 NOS1 NOS2 NOS3
17 negative regulation of hydrolase activity GO:0051346 9.56 NOS1 NOS3
18 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.54 EDN1 NOS3
19 regulation of blood vessel size GO:0050880 9.54 EDN1 KNG1 NOS3
20 peptidyl-cysteine S-nitrosylation GO:0018119 9.49 NOS1 NOS2
21 positive regulation of oocyte development GO:0060282 9.46 PDE3A PDE5A
22 negative regulation of potassium ion transport GO:0043267 9.43 NOS1 NOS3 VIP
23 positive regulation of guanylate cyclase activity GO:0031284 9.33 NOS1 NOS2 NOS3
24 arginine catabolic process GO:0006527 9.13 NOS1 NOS2 NOS3
25 nitric oxide biosynthetic process GO:0006809 8.92 ARG2 NOS1 NOS2 NOS3
26 oxidation-reduction process GO:0055114 10 ALDH7A1 CYP3A4 NOS1 NOS2 NOS3 SRD5A1

Molecular functions related to Impotence according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.85 ALDH7A1 CYP3A4 NOS1 NOS2 NOS3 SRD5A1
2 heme binding GO:0020037 9.71 CYP3A4 NOS1 NOS2 NOS3
3 hormone activity GO:0005179 9.67 EDN1 PRL VIP
4 flavin adenine dinucleotide binding GO:0050660 9.65 NOS1 NOS2 NOS3
5 NADP binding GO:0050661 9.61 NOS1 NOS2 NOS3
6 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 9.54 PDE3A PDE5A
7 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.51 PDE3A PDE5A
8 FMN binding GO:0010181 9.5 NOS1 NOS2 NOS3
9 cadmium ion binding GO:0046870 9.46 NOS1 NOS3
10 arginine binding GO:0034618 9.43 NOS1 NOS2 NOS3
11 NADPH-hemoprotein reductase activity GO:0003958 9.33 NOS1 NOS2 NOS3
12 tetrahydrobiopterin binding GO:0034617 9.13 NOS1 NOS2 NOS3
13 nitric-oxide synthase activity GO:0004517 8.8 NOS1 NOS2 NOS3
14 protein binding GO:0005515 10.4 ALDH7A1 EDN1 KCNMA1 KLK3 KNG1 NOS1

Sources for Impotence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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