Impotence disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IMP005 MIFTS: 57	Impotence Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Impotence

MalaCards integrated aliases for Impotence:

Name: Impotence ¹² ²⁹ ⁵⁵ ¹⁵

Erectile Dysfunction ¹² ⁵⁵ ⁴³ ¹⁵ ⁷³

Erectile Dysfunction Adverse Event ⁷³

Sexual Impotence ¹²

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1875

UMLS ⁷³ C0242350 C1961100

Sources

Summaries for Impotence

MedlinePlus : ⁴³ Erectile dysfunction (ED) is a common type of male sexual dysfunction. It is when a man has trouble getting or keeping an erection. ED becomes more common as you get older. But it's not a natural part of aging. Some people have trouble speaking with their doctors about sex. But if you have ED, you should tell your doctor. ED can be a sign of health problems. It may mean your blood vessels are clogged. It may mean you have nerve damage from diabetes. If you don't see your doctor, these problems will go untreated. Your doctor can offer several new treatments for ED. For many men, the answer is as simple as taking a pill. Getting more exercise, losing weight, or stopping smoking may also help. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Impotence, also known as erectile dysfunction, is related to vasculogenic impotence and peyronie disease, and has symptoms including tremor, angina pectoris and pelvic pain. An important gene associated with Impotence is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Platelet homeostasis. The drugs Testosterone and Testosterone enanthate have been mentioned in the context of this disorder. Affiliated tissues include prostate, endothelial and spinal cord, and related phenotypes are normal and reproductive system

Wikipedia : ⁷⁶ Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the... more...

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Related Diseases for Impotence

Diseases related to Impotence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)

#	Related Disease	Score	Top Affiliating Genes
1	vasculogenic impotence	33.6	ALDH7A1 NOS3 PDE5A
2	peyronie disease	32.4	NOS2 PDE5A
3	prostatic adenoma	30.8	KLK3 SRD5A1
4	ischemic optic neuropathy	30.6	EDN1 NOS3 PDE5A
5	nonarteritic anterior ischemic optic neuropathy	30.6	EDN1 NOS3 PDE5A
6	arteries, anomalies of	30.6	EDN1 KNG1 NOS3
7	coronary artery anomaly	30.5	EDN1 KNG1 NOS3
8	hyperprolactinemia	30.4	PRL SHBG VIP
9	gynecomastia	30.3	KLK3 PRL SHBG
10	vascular disease	29.9	EDN1 KNG1 NOS2 NOS3
11	varicocele	29.9	NOS2 NOS3 PRL SHBG
12	androgenic alopecia	29.9	KLK3 PRL SHBG
13	ischemia	29.9	EDN1 KNG1 NOS1 NOS2 NOS3
14	hypertension, essential	29.8	EDN1 KNG1 NOS2 NOS3
15	rhinitis	29.7	CYP3A4 KNG1 VIP
16	alopecia, androgenetic, 1	29.6	SHBG SRD5A1
17	prostatic hyperplasia, benign	29.5	KLK3 PDE5A SHBG SRD5A1
18	pulmonary hypertension	29.5	EDN1 NOS2 NOS3 PDE5A VIP
19	sexual disorder	29.1	ALDH7A1 EDN1 KCNMA1 KLK3 NOS1 NOS3
20	multiple system atrophy 1	11.4
21	autonomic nervous system disease	11.4
22	diabetic neuropathy	11.4
23	pituitary adenoma 4, acth-secreting	11.1
24	paroxysmal nocturnal hemoglobinuria 1	11.1
25	microvascular complications of diabetes 1	11.1
26	tabes dorsalis	11.1
27	kallmann syndrome	11.1
28	pure autonomic failure	11.1
29	amyloidosis, hereditary, transthyretin-related	11.0
30	neuropathy, hereditary sensory and autonomic, type iii	11.0
31	empty sella syndrome	11.0
32	tarlov cysts	11.0
33	dysautonomia	11.0
34	diabetes mellitus, noninsulin-dependent	10.4
35	sleep apnea	10.4
36	peyronie's disease	10.3
37	heart disease	10.3
38	optic nerve disease	10.3
39	gout	10.3
40	prostatitis	10.3
41	hypogonadotropism	10.3
42	prostate cancer	10.3
43	myocardial infarction	10.2
44	periodontitis	10.2
45	cluster headache	10.2	NOS1 PRL VIP
46	atrial fibrillation	10.2
47	melanoma	10.2
48	psoriasis	10.2
49	platelet membrane fluidity	10.2	NOS2 NOS3
50	aging	10.2

Graphical network of the top 20 diseases related to Impotence:

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Symptoms & Phenotypes for Impotence

UMLS symptoms related to Impotence:

tremor, angina pectoris, pelvic pain, equilibration disorder, symptom/complaint potency (excluding p07 p08), inability to maintain erection, unable to perform sex

MGI Mouse Phenotypes related to Impotence:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal	MP:0002873	9.56	ALDH7A1 EDN1 NOS1 NOS3 PDE3A SEPT3
2	reproductive system	MP:0005389	9.23	KCNMA1 NOS1 NOS2 NOS3 PDE3A PRL

Sources

Drugs & Therapeutics for Impotence

Drugs for Impotence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 333)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Testosterone

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

58-22-0

6013

Testosterone enanthate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

315-37-7

9416

Testosterone undecanoate

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

5949-44-0

Methyltestosterone

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

58-18-4

6010

tannic acid

Approved

Phase 4,Phase 3

Benzocaine

Approved, Investigational

Phase 4,Phase 3

94-09-7, 1994-09-7

2337

Tadalafil

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

171596-29-5

110635

Nebivolol

Approved, Investigational

Phase 4,Not Applicable

99200-09-6, 152520-56-4, 118457-14-0

71301

Fenofibrate

Approved

Phase 4,Phase 3

49562-28-9

3339

Felodipine

Approved, Investigational

Phase 4

72509-76-3

3333

Irbesartan

Approved, Investigational

Phase 4

138402-11-6

3749

Metoprolol

Approved, Investigational

Phase 4,Phase 3,Not Applicable

37350-58-6, 51384-51-1

4171

Angiotensin II

Approved, Investigational

Phase 4

11128-99-7, 68521-88-0, 4474-91-3

172198 65143

Dutasteride

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

164656-23-9

6918296 152945

Tamsulosin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

106133-20-4

129211

Alprostadil

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

745-65-3

149351 5280723

Nitric Oxide

Approved

Phase 4

10102-43-9

145068

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492

Zinc

Approved, Investigational

Phase 4

7440-66-6

Curcumin

Approved, Experimental, Investigational

Phase 4

458-37-7

969516

Allantoin

Approved

Phase 4

97-59-6

204

Yohimbine

Approved, Investigational, Vet_approved

Phase 4

146-48-5

8969

Hydrochlorothiazide

Approved, Vet_approved

Phase 4,Phase 3

58-93-5

3639

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Tiagabine

Approved, Investigational

Phase 4

115103-54-3

60648

Magnesium oxide

Approved

Phase 4

1309-48-4

14792

Isosorbide Dinitrate

Approved, Investigational

Phase 4

87-33-2

6883

Nadolol

Approved

Phase 4

42200-33-9

39147

AT-101

Approved, Investigational

Phase 4

90141-22-3, 652-67-5

12597

Carvedilol

Approved, Investigational

Phase 4

72956-09-3

2585

Eszopiclone

Approved, Investigational

Phase 4

138729-47-2

969472

Celecoxib

Approved, Investigational

Phase 4

169590-42-5

2662

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Xylometazoline

Approved, Investigational

Phase 4

526-36-3

5709

Candesartan cilexetil

Approved

Phase 4

145040-37-5

2540

Polyestradiol phosphate

Approved

Phase 4,Phase 1

28014-46-2

Estradiol

Approved, Investigational, Vet_approved

Phase 4,Phase 1

50-28-2

5757

Estradiol valerate

Approved, Investigational, Vet_approved

Phase 4,Phase 1

979-32-8

Rosiglitazone

Approved, Investigational

Phase 4,Phase 1

122320-73-4

77999

Selegiline

Approved, Investigational, Vet_approved

Phase 4

14611-51-9

26757 5195

Pioglitazone

Approved, Investigational

Phase 4

111025-46-8

4829

Orange

Approved

Phase 4

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

77-92-9

311

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4,Not Applicable

1406-16-2

Ergocalciferol

Approved, Nutraceutical

Phase 4

50-14-6

5280793

N,N-dimethylarginine

Experimental

Phase 4

30315-93-6

123831

Udenafil

Investigational

Phase 4,Phase 3,Phase 2,Phase 1

268203-93-6

6918523

Candesartan

Experimental

Phase 4

139481-59-7

2541

2,4-thiazolidinedione

Investigational

Phase 4

2295-31-0

Androgens

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 630)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of Erectile Dysfunction in Hypogonadal Men With Testosterone Undecanoate	Unknown status	NCT00555087	Phase 4	Testosterone Undecanoate and/or PDE-5
2	A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury	Unknown status	NCT00725790	Phase 4	Vardenafil;Placebo
3	Effect of Tadalafil on Erectile Dysfunction Treatment and QOL Improvement Effect (by SF-12) in Andropause Patients With Erectile Dysfunction	Unknown status	NCT02943356	Phase 4	Tadalafil
4	Effect of Vardenafil on Erectile Dysfunction and Portal Hemodynamics in Patients With Liver Cirrhosis	Unknown status	NCT02344823	Phase 4	Vardenafil;Placebo intake once daily
5	Nebivolol Effects on Endothelial Function and Erectile Function	Unknown status	NCT01885988	Phase 4	Nebivolol;Sugar Pill
6	Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer	Unknown status	NCT00906269	Phase 4	Sildenafil therapy plus post-NSRRP HBO2T;Sildenafil therapy plus sham post-NSRRP HBO2T
7	Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i	Unknown status	NCT00498680	Phase 4	Sildenafil, Vardenafil;Sildenafil;Vardenafil;Sildenafil & Vardenafil
8	Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment	Unknown status	NCT01364701	Phase 4	Sildenafil 100 mg;Tadalafil 20 mg;Combination half of maximal dose for sildenafil & tadalafil
9	Effect of Sildenafil on Quality of Sexual Life in Mild to Normally Sexually Functioning Males	Unknown status	NCT00313898	Phase 4	sildenafil (viagra)
10	Nerve Grafting With an Allograft During Radical Prostatectomy - Extended Follow-up in a Prospective Randomized Trial	Unknown status	NCT01770340	Phase 4
11	Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism	Unknown status	NCT01084369	Phase 4	Testosterone
12	Treatment of Hyperlipidemia and Sexual Dysfunction	Unknown status	NCT00923676	Phase 4	fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
13	Combined Antihypertensive Therapy and Sexual Dysfunction	Unknown status	NCT01238705	Phase 4	Felodipine add Irbesartan;Felodipine add Metoprolol
14	A Study in Patients With Erectile Dysfunction	Completed	NCT01122264	Phase 4	Tadalafil;Sildenafil Citrate
15	Impact Of Viagra On Sexual Satisfaction Of Men With Mild Erectile Dysfunction Who Are Sexually Dissatisfied	Completed	NCT00301262	Phase 4	Viagra (Sildenafil citrate)
16	Evaluation of LEVITRA to Advance the Treatment of Erectile Dysfunction	Completed	NCT00664833	Phase 4
17	L-Arginine and Erectile Dysfunction	Completed	NCT00777075	Phase 4	L-arginine;Placebo
18	Effect of Tadalafil on the Quality of Life and Sexual Life in Erectile Dysfunction	Completed	NCT00422578	Phase 4	tadalafil
19	Investigate the Responsiveness of the Erectile Quality Scale to Vardenafil Flexible Dose vs Placebo in Males With Erectile Dysfunction (ED)	Completed	NCT00665340	Phase 4	Placebo;Levitra (Vardenafil, BAY38-9456)
20	Vardenafil and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV)	Completed	NCT02450188	Phase 4	Vardenafil
21	Evaluating of the Efficacy and Safety of Vardenafil in Subjects With Erectile Dysfunction	Completed	NCT00662441	Phase 4	Levitra (Vardenafil, BAY38-9456)
22	Assessing Efficacy and Safety of Flexible Dosing With Vardenafil in Subjects With Erectile Dysfunction and Hyperlipidemia	Completed	NCT00663845	Phase 4	Levitra (Vardenafil, BAY38-9456);Placebo
23	Assessment of Vardenafil in Patients With Erectile Dysfunction in Asia	Completed	NCT00668135	Phase 4	Vardenafil (Levitra, BAY38-9456);Placebo
24	Evaluation of the Safety and Efficacy of Vardenafil in Subjects With Erectile Dysfunction	Completed	NCT00681772	Phase 4	Levitra (Vardenafil, BAY38-9456)
25	Satisfaction, Confidence and Naturalness in Men With Psychogenic Erectile Dysfunction (ED)	Completed	NCT01153204	Phase 4	Sildenafil citrate
26	Mild To Moderate Erectile Dysfunction Study	Completed	NCT00137072	Phase 4	Viagra (Sildenafil Citrate) 100 mg
27	Efficacy and Safety of Lodenafil Carbonate in the Treatment of Erectile Dysfunction in Patients With Diabetes.	Completed	NCT01180283	Phase 4	lodenafil carbonate
28	Study Of Men With Mild To Moderate Erectile Dysfunction To Evaluate The Efficacy Of Viagra 8 Hours Post-Dose	Completed	NCT00143260	Phase 4	Viagra (Sildenafil Citrate) 100 mg
29	BAY38-9456, 5/10/20mg, vs.Placebo in Erectile Dysfunction	Completed	NCT00665054	Phase 4	Levitra (Vardenafil, BAY38-9456);Placebo
30	A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China	Completed	NCT01352507	Phase 4	Tadalafil;Sildenafil
31	Use of Sildenafil (Viagra) in Diabetic Men With Erectile Dysfunction: the Impact on Blood Vessels	Completed	NCT00199563	Phase 4	Viagra
32	Evaluation of Efficacy and Safety of Vardenafil in Patients With Erectile Dysfunction and Type 1 Diabetes	Completed	NCT00660998	Phase 4	Levitra (Vardenafil, BAY38-9456);Placebo
33	Study of Vardenafil in Patients Suffering From Erectile Dysfunction and Metabolic Syndrome	Completed	NCT00738400	Phase 4	Vardenafil (Levitra, BAY38-9456);Placebo
34	A Safety and Efficacy Study of Prograf in the Prevention of Erectile Dysfunction After Radical Prostatectomy	Completed	NCT00106392	Phase 4	Tacrolimus;Placebo
35	The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction	Completed	NCT00421460	Phase 4	Testosterone Undecanoate,1000mg
36	A Study Evaluating Vardenafil Compared to Placebo in Subjects With Erectile Dysfunction (ED) and Dyslipidemia	Completed	NCT00379756	Phase 4	LEVITRA (vardenafil);placebo
37	Research Evaluating a PDE5 Inhibitor for Erectile Dysfunction	Completed	NCT01698684	Phase 4	Placebo;Avanafil 100 mg;Avanafil 200 mg
38	A Study of Tadalafil (LY450190) in Chinese Men With Erectile Dysfunction	Completed	NCT02224846	Phase 4	Tadalafil
39	QEQ Treatment Responsiveness Evaluation Study	Completed	NCT00151463	Phase 4	sildenafil citrate
40	Quality of Erection Study	Completed	NCT00159900	Phase 4	Sildenafil Citrate
41	Evaluating the Efficacy Vardenafil 10 mg vs Tadalafil 10 mg in in Subjects With Erectile Dysfunction (ED)	Completed	NCT00663130	Phase 4	Levitra (Vardenafil, BAY38-9456);Tadalafil
42	A Multicenter, Randomized, Parallel Group, Double-Blind, Placebo Controlled, Flexible Dose Escalation Study To Evaluate Sexual And Relationship Satisfaction In The Female Partner Of Men With Erectile Dysfunction Treated With Sildenafil Citrate	Completed	NCT00644631	Phase 4	sildenafil;placebo
43	Effect of Testosterone in Men With Erectile Dysfunction	Completed	NCT00512707	Phase 4	Sildenafil citrate (open label);Testosterone gel
44	A Multicenter, Open Label, To Evaluate The Efficacy And Satisfaction Of Patrex® In Men With Erectile Dysfunction.	Completed	NCT00468650	Phase 4	sildenafil citrate
45	Effects of Sildenafil on Penile Vascular Function in Hypertensive Men With Erectile Dysfunction	Completed	NCT02620995	Phase 4	sildenafil citrate
46	A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil	Completed	NCT00644956	Phase 4	tadalafil;sildenafil
47	A Study Of The Safety and Efficacy Of Viagra In Men With Erectile Dysfunction Who Do Not Self Identify.	Completed	NCT00343200	Phase 4	Placebo;Viagra (sildenafil citrate)
48	Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients	Completed	NCT01468519	Phase 4	Insulin;Insulin
49	Efficacy Study Measuring The Impact Of Treatment With Viagra On The Depressive Symptoms Of Men With Erectile Dysfunction	Completed	NCT00159809	Phase 4	Viagra (Sildenafil citrate)
50	A Study Evaluating the Efficacy and Safety of Sildenafil in Patients With Erectile Dysfunction Receiving Hemodialysis	Completed	NCT00654017	Phase 4	placebo;sildenafil

Search NIH Clinical Center for Impotence

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

ginseng preparation

methyltestosterone

methyltestosterone pwdr

papaverine

papaverine hydrochloride

yohimbine

yohimbine hydrochloride

Sources

Genetic Tests for Impotence

Genetic tests related to Impotence:

#	Genetic test	Affiliating Genes
1	Impotence ²⁹

Sources

Anatomical Context for Impotence

MalaCards organs/tissues related to Impotence:

⁴¹

Prostate, Endothelial, Spinal Cord, Kidney, Bone, Testes, Heart

Sources

Publications for Impotence

Articles related to Impotence:

(show top 50) (show all 2622)

#	Title	Authors	Year
1	Newly Diagnosed Bipolar Disorder and the Subsequent Risk of Erectile Dysfunction: A Nationwide Cohort Study. ( 29425665 )	Hou P.H....Huang S.S.	2018
2	Large Solitary Plexiform Neurofibroma of the Penis Without Erectile Dysfunction: a Case Report from Kerala. ( 29581693 )	Cholakkal S....Nachiketh G.	2018
3	A case of pheochromocytoma with negative MIBG scintigraphy, PET-CT and genetic tests (VHL included) and a rare case of post-operative erectile dysfunction. ( 29860716 )	Defeudis G....Manfrini S.	2018
4	Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta-analysis. ( 29341503 )	Wang Y....Cui Y.	2018
5	Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction. ( 29405168 )	Chen X....Dai J.C.	2018
6	The relationship between penile deformity, age, psychological bother, and erectile dysfunction in a sample of men with Peyronie's Disease (PD). ( 29795530 )		2018
7	Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study. ( 29344879 )		2018
8	Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension. ( 29368385 )		2018
9	A Novel Noninvasive Ultrasound Vibro-elastography Technique for Assessing Patients With Erectile Dysfunction and Peyronie Disease. ( 29548864 )		2018
10	Malleable Penile Implant Is an Effective Therapeutic Option in Men With Peyronie's Disease and Erectile Dysfunction. ( 29336942 )		2018
11	Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors. ( 29442076 )		2018
12	Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia. ( 30209896 )	Shin YS...Park JK	2018
13	Erectile dysfunction among patients with chronic brucellosis. ( 30154453 )	Safwat AS...Nafee A	2018
14	Frequency of Erectile Dysfunction in Males with Central Serous Chorioretinopathy. ( 28328282 )	Balkarli A...Erol RS	2018
15	Chronic graft versus host disease is associated with erectile dysfunction in allogeneic hematopoietic stem cell transplant patients: a single-center experience. ( 29561209 )	Andreini A...Tecchio C	2018
16	Increased Use of Medications for Erectile Dysfunction in Men With Ulcerative Colitis and Crohn's Disease Compared to Men Without Inflammatory Bowel Disease: A Nationwide Cohort Study. ( 29988041 )	Friedman S...N?rg?rd BM	2018
17	Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: Protocol for a systematic review: Erratum. ( 30383706 )		2018
18	Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: Protocol for a systematic review. ( 30290616 )	Li X...Wang B	2018
19	A meta-analysis on efficacy and tolerability of sildenafil for erectile dysfunction in patients with diabetes mellitus. ( 30187018 )	Shah PC...Trivedi NA	2018
20	Re: Real-World Observational Results from a Database of 48 Million Men in the United States: Relationship of Cardiovascular Disease, Diabetes Mellitus and Depression with Age and Erectile Dysfunction. ( 30227549 )	Seftel AD	2018
21	Gout and the Risk of Incident Erectile Dysfunction: A Body Mass Index-matched Population-based Study. ( 30008453 )	Schlesinger N...Choi HK	2018
22	Prevalence and risk factors of erectile dysfunction in patients with hepatitis B virus or hepatitis C virus or chronic liver disease: results from a prospective study. ( 30045807 )	Gentile I...Longo N	2018
23	Homocysteine, insulin-like growth factor one and oestrogen levels in patients with erectile dysfunction-associated chronic hepatitis C virus infection. ( 30063074 )	Abdelhamid AA...El-Sakka AI	2018
24	Frequency of Hypogonadism and Erectile Dysfunction in Type-II Diabetic Patients. ( 30034976 )	Mushtaq S...Raza T	2018
25	Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study. ( 30253697 )	GamalEl Din SF...Elnabarway RR	2018
26	The association between subclinical hypothyroidism and erectile dysfunction. ( 30034427 )	Chen D...Tian H	2018
27	The Magic Pill: The Branding of Impotence and the Positioning of Viagra as Its Solution through Edutainment. ( 29436964 )	Gesser-Edelsburg A...Hijazi R	2018
28	Value of flaccid penile ultrasound in screening for arteriogenic impotence: a preliminary prospective study. ( 30400881 )	Chen LD...Wang W	2018
29	Management of Erectile Dysfunction and Infertility in the Male Spinal Cord Injury Patient. ( 29774436 )	Fenstermaker M...Ohl DA	2018
30	Evaluation of Prolidase Activity, Oxidative Stress, and Antioxidant Enzyme Levels in Testicular and Penile Tissues after Human Chorionic Gonadotropin Treatment in Rats by Predicting Infertility and Erectile Dysfunction. ( 29506009 )	Pirin??i N...Karakeci A	2018
31	Anterior Ischemic Optic Neuropathy in a Patient with Erectile Dysfunction: Tadalafil as an Offending Medication. ( 30211242 )	Dehghani A...Pourazizi M	2018
32	Erectile dysfunction in compensated liver cirrhosis. ( 30467076 )	Maimone S...Raimondo G	2018
33	Association Between Periodontal Disease and Erectile Dysfunction: A Systematic Review. ( 27030114 )	Kellesarian SV...Javed F	2018
34	Chronic periodontitis is associated with erectile dysfunction. A case-control study in european population. ( 29723438 )	Mart?n A...Mesa F	2018
35	Re: Extracorporeal Shock Wave Therapy (ESWT) in Urology: A Systematic Review of Outcome in Peyronie's Disease, Erectile Dysfunction, and Chronic Pelvic Pain. ( 29449032 )	Rassweiler J	2018
36	Clinical characteristics of men complaining of premature ejaculation together with erectile dysfunction: a cross-sectional study. ( 30556353 )	Rastrelli G...Maggi M	2018
37	Men's health 2018: BPH, prostate cancer, erectile dysfunction, supplements. ( 30395524 )	Chaitoff A...Nielsen C	2018
38	High prevalence of erectile dysfunction in men with psoriasis: evidence from a systematic review and meta-analysis. ( 30470802 )	Zhao S...Zhao Z	2018
39	Association Between Psoriasis and Sexual and Erectile Dysfunction in Epidemiologic Studies: A Systematic Review. ( 30304327 )	Molina-Leyva A...Arias-Santiago S	2018
40	Sex hormones, erectile dysfunction, and psoriasis; a bad friendship! ( 30105747 )	Eltaweel AEAI...Algaod FA	2018
41	Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis. ( 29735408 )	Wu T...Yu X	2018
42	Risk of Melanoma With Phosphodiesterase Type 5 Inhibitor Use Among Patients With Erectile Dysfunction, Pulmonary Hypertension, and Lower Urinary Tract Symptoms. ( 29884444 )	Shkolyar E...Eisenberg ML	2018
43	Pelvic chondro-sarcoma and erectile dysfunction: A challenging surgical case. ( 30063021 )	GamalEl Din SF...Abo Senna WG	2018
44	Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP). ( 30089160 )	Pascual M...S?nchez-de-la-Torre M	2018
45	The Effects of Sildenafil on the Respiratory System of Patients With Obstructive Sleep Apnea and Erectile Dysfunction. ( 29734993 )	Andersen ML...Tufik S	2018
46	Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis. ( 29795528 )	Kellesarian SV...Javed F	2018
47	R46L polymorphism in the PCSK9 gene: Relationship to lipid levels, subclinical vascular disease, and erectile dysfunction. ( 29773421 )	Mostaza JM...investigators of the SPREDIA-2 Group	2018
48	Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis. ( 29891569 )	Uddin SMI...Blaha MJ	2018
49	Accurate and sensitive determination of sildenafil, tadalafil, vardenafil, and avanafil in illicit erectile dysfunction medications and human urine by LC with quadrupole-TOF-MS/MS and their behaviors in simulated gastric conditions. ( 30358113 )	?zt?rk Er E...Bak?rdere S	2018
50	Diagnosis of erectile dysfunction can be used to improve screening for Type 2 diabetes mellitus. ( 30028534 )	Carrillo-Larco RM...Bernab?-Ortiz A	2018

Sources

Genes for Impotence

Genes related to Impotence (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NOS1	Nitric Oxide Synthase 1	Protein Coding	43.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7588327 10630682 9284206 (more) 9631946 8562693 16247643 14988755 12879106 12425869 14636078 10611201 16422964 10753463 19507217 11157892 17570156 10524946 16815627 14562136 11289565 15533731
2	PDE5A	Phosphodiesterase 5A	Protein Coding	39.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	10541153 18778098 12789393 (more) 17017938 12192104 17253475 17948826 17076943 18674473 20092451 15183543 18572866 16465185 15941818 19234311 16760637 16913726 10753463 17888073 17625575 16985897 18528398 16212722 17655683 16901064 19884625 9598563 10078541 10859452 12494279 15224136 16759100 16780568 17947271 20043970 19686427 20112748 19036180 18395326 18385912 18086159 18304285 17942972 18075506 17969789 17943864 17307372 17034932 17321461 16387566 16480739 16884667 15102574 14693299 12625846 10078540 10078538 10078537 8858389 19125990 19210710 16979814 17100936 16956354 16236060 16839323 16985983 16422974 16755146 16422803 16387564 16281846 14622499 12437503 12414329 12209148 9916601 20402554 19860698 19377497 19138360 18998474 18673225 18548330 17393785 17471999 17233781 16422913 16387565 16247643 15850242 15648556 15175637 15242361 15224127 19701217 19170852 19387454 19010346 18331258 19288756 18976905 18281145 15766322
3	PRL	Prolactin	Protein Coding	38.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9334596 8801788 17213792 (more) 15794243 16728967 9934944 12771765 15230214 15277002 16985734 11525317 16466670 15206663 17125484 17724876 8077999 12522680 19365914 1352308 7555478 8800626 17040261 18082643 8845563 8683729 7824423 11111867
4	KLK3	Kallikrein Related Peptidase 3	Protein Coding	32.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	18423715 9334599 18001791 (more) 12399540 15711315 15852361 15201795 19095127 17137429 16422891 17030406 12771765 11421528 20022032 18614145 15201794 18217535 11752011 15491704 8795650 11121994 11325208
5	VIP	Vasoactive Intestinal Peptide	Protein Coding	28.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1522236 8981173 14617572 (more) 7601214 2405186 11678758
6	SHBG	Sex Hormone Binding Globulin	Protein Coding	25.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8274414 17961146 15794243
7	NOS3	Nitric Oxide Synthase 3	Protein Coding	25.49	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	10553806 19466514 16871271 (more) 16085713 18572862 16528291 19800665 15292102 14522830 15711333 16409219 9631946 17457350 19907424
8	KCNMA1	Potassium Calcium-Activated Channel Subfamily M Alpha 1	Protein Coding	24.38	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	10467518 12879112 15964135 (more) 17402321 17134370 7861546
9	NOS2	Nitric Oxide Synthase 2	Protein Coding	22.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	16888082 9096878 11781741 (more) 16507050 9631946 12879114 18644193 16554854 12789386 16378509
10	EDN1	Endothelin 1	Protein Coding	20.65	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	9334598 17222652 16225532 (more) 11550788 17611982 7752383 11760787 7658593
11	PDE3A	Phosphodiesterase 3A	Protein Coding	18.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	10421499 10859452
12	SEPT6	Septin 6	Protein Coding	18.26	DISEASES inferred ¹⁵
13	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	17.75	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	19143914 16282844 11879258
14	ALDH7A1	Aldehyde Dehydrogenase 7 Family Member A1	Protein Coding	17.7	DISEASES inferred ¹⁵
15	KNG1	Kininogen 1	Protein Coding	16.68	GeneCards inferred via : Publications (show sections)
16	SRD5A1	Steroid 5 Alpha-Reductase 1	Protein Coding	14.18	Novoseek inferred ⁵⁵	1841751 15371854 18421068 (more) 16110128 19002123 17166332 19090946 17265598 16507052 18163946
17	ARG2	Arginase 2	Protein Coding	9.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	11350073 11370664 12859189
18	SEPT3	Septin 3	Protein Coding	8.69	DISEASES inferred ¹⁵

Sources

Variations for Impotence

Sources

Expression for Impotence

Search GEO for disease gene expression data for Impotence.

Sources

Pathways for Impotence

Pathways related to Impotence according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.1	KCNMA1 KNG1 NOS1 NOS2 NOS3 PDE3A
2	Platelet homeostasis ⁶⁶ Show member pathways Elevation of cytosolic Ca2+ levels ⁶⁶ Platelet calcium homeostasis ⁶⁶ Platelet sensitization by LDL ⁶⁶ Prostacyclin signalling through prostacyclin receptor ⁶⁶ Reduction of cytosolic Ca++ levels ⁶⁶	12.01	KCNMA1 NOS1 NOS2 NOS3 PDE3A PDE5A
3	Apelin signaling pathway ³⁷	11.84	NOS1 NOS2 NOS3
4	HIF-1 signaling pathway ³⁷	11.69	EDN1 NOS2 NOS3
5	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) ²² Show member pathways CFTR folding and maturation (norm and CF) ²²	11.44	NOS1 NOS2 NOS3
6	Arginine and proline metabolism ³⁷ Show member pathways 4-hydroxyproline degradation ¹ Agmatine biosynthesis ⁶⁶ putrescine biosynthesis II ¹	11.31	ALDH7A1 ARG2 NOS1 NOS2 NOS3
7	Doxorubicin Pathway, Pharmacokinetics ⁶¹ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶¹	11.23	NOS1 NOS2 NOS3
8	Ibuprofen Pathway, Pharmacodynamics ⁶¹	11.06	NOS1 NOS2 NOS3
9	Arginine biosynthesis ³⁷ Show member pathways citrulline-nitric oxide cycle ¹	11.04	ARG2 NOS1 NOS2 NOS3
10	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics ⁶¹	10.96	NOS1 NOS2 NOS3
11	Nitric oxide stimulates guanylate cyclase ⁶⁶ Show member pathways cGMP effects ⁶⁶	10.72	KCNMA1 NOS1 NOS2 NOS3 PDE3A PDE5A
12	Effects of Nitric Oxide ¹	10.45	NOS1 NOS2 NOS3
13	NO-dependent CFTR activation (normal and CF) ²²	10.37	NOS1 NOS2 NOS3 PDE5A

Sources

GO Terms for Impotence

Cellular components related to Impotence according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	septin complex	GO:0031105	9.32	SEPT3 SEPT6
2	septin filament array	GO:0032160	9.26	SEPT3 SEPT6
3	septin ring	GO:0005940	9.16	SEPT3 SEPT6
4	caveola	GO:0005901	9.13	KCNMA1 NOS1 NOS3
5	vesicle membrane	GO:0012506	8.8	NOS1 NOS2 NOS3

Biological processes related to Impotence according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.92	EDN1 PDE3A PRL SRD5A1
2	response to hypoxia	GO:0001666	9.81	EDN1 KCNMA1 NOS1 NOS2
3	cell redox homeostasis	GO:0045454	9.74	NOS1 NOS2 NOS3
4	response to hormone	GO:0009725	9.72	NOS1 NOS2 NOS3
5	response to lipopolysaccharide	GO:0032496	9.72	EDN1 NOS1 NOS2 NOS3 PRL
6	negative regulation of blood pressure	GO:0045776	9.65	NOS1 NOS2 NOS3
7	regulation of sodium ion transport	GO:0002028	9.63	NOS1 NOS3
8	androgen metabolic process	GO:0008209	9.62	CYP3A4 SRD5A1
9	striated muscle contraction	GO:0006941	9.61	ARG2 NOS1
10	negative regulation of blood coagulation	GO:0030195	9.61	EDN1 KNG1
11	vasodilation	GO:0042311	9.61	KNG1 NOS1 NOS3
12	septin ring assembly	GO:0000921	9.6	SEPT3 SEPT6
13	negative regulation of calcium ion transport	GO:0051926	9.59	NOS1 NOS3
14	body fluid secretion	GO:0007589	9.58	EDN1 VIP
15	multicellular organismal response to stress	GO:0033555	9.58	NOS1 PRL
16	nitric oxide mediated signal transduction	GO:0007263	9.58	NOS1 NOS2 NOS3
17	negative regulation of hydrolase activity	GO:0051346	9.56	NOS1 NOS3
18	regulation of systemic arterial blood pressure by endothelin	GO:0003100	9.54	EDN1 NOS3
19	regulation of blood vessel size	GO:0050880	9.54	EDN1 KNG1 NOS3
20	peptidyl-cysteine S-nitrosylation	GO:0018119	9.49	NOS1 NOS2
21	positive regulation of oocyte development	GO:0060282	9.46	PDE3A PDE5A
22	negative regulation of potassium ion transport	GO:0043267	9.43	NOS1 NOS3 VIP
23	positive regulation of guanylate cyclase activity	GO:0031284	9.33	NOS1 NOS2 NOS3
24	arginine catabolic process	GO:0006527	9.13	NOS1 NOS2 NOS3
25	nitric oxide biosynthetic process	GO:0006809	8.92	ARG2 NOS1 NOS2 NOS3
26	oxidation-reduction process	GO:0055114	10	ALDH7A1 CYP3A4 NOS1 NOS2 NOS3 SRD5A1

Molecular functions related to Impotence according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.85	ALDH7A1 CYP3A4 NOS1 NOS2 NOS3 SRD5A1
2	heme binding	GO:0020037	9.71	CYP3A4 NOS1 NOS2 NOS3
3	hormone activity	GO:0005179	9.67	EDN1 PRL VIP
4	flavin adenine dinucleotide binding	GO:0050660	9.65	NOS1 NOS2 NOS3
5	NADP binding	GO:0050661	9.61	NOS1 NOS2 NOS3
6	3',5'-cyclic-GMP phosphodiesterase activity	GO:0047555	9.54	PDE3A PDE5A
7	3',5'-cyclic-nucleotide phosphodiesterase activity	GO:0004114	9.51	PDE3A PDE5A
8	FMN binding	GO:0010181	9.5	NOS1 NOS2 NOS3
9	cadmium ion binding	GO:0046870	9.46	NOS1 NOS3
10	arginine binding	GO:0034618	9.43	NOS1 NOS2 NOS3
11	NADPH-hemoprotein reductase activity	GO:0003958	9.33	NOS1 NOS2 NOS3
12	tetrahydrobiopterin binding	GO:0034617	9.13	NOS1 NOS2 NOS3
13	nitric-oxide synthase activity	GO:0004517	8.8	NOS1 NOS2 NOS3
14	protein binding	GO:0005515	10.4	ALDH7A1 EDN1 KCNMA1 KLK3 KNG1 NOS1

Sources

Sources for Impotence

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Impotence

Aliases & Classifications for Impotence

MalaCards integrated aliases for Impotence:

Classifications:

External Ids:

Summaries for Impotence

Related Diseases for Impotence

Diseases related to Impotence via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Impotence:

Symptoms & Phenotypes for Impotence

UMLS symptoms related to Impotence:

MGI Mouse Phenotypes related to Impotence:

Drugs & Therapeutics for Impotence

Drugs for Impotence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Genetic Tests for Impotence

Genetic tests related to Impotence:

Anatomical Context for Impotence

MalaCards organs/tissues related to Impotence:

Publications for Impotence

Articles related to Impotence:

Genes for Impotence

Genes related to Impotence (0 elite genes):

Variations for Impotence

Expression for Impotence

Pathways for Impotence

Pathways related to Impotence according to GeneCards Suite gene sharing:

GO Terms for Impotence

Cellular components related to Impotence according to GeneCards Suite gene sharing:

Biological processes related to Impotence according to GeneCards Suite gene sharing:

Molecular functions related to Impotence according to GeneCards Suite gene sharing:

Sources for Impotence

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :