in Situ Pulmonary Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for in Situ Pulmonary Adenocarcinoma

MalaCards integrated aliases for in Situ Pulmonary Adenocarcinoma:

Name: in Situ Pulmonary Adenocarcinoma ¹² ¹⁵

Bronchioloalveolar Adenocarcinoma ⁷³

Bronchioalveolar Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050870

Sources

Summaries for in Situ Pulmonary Adenocarcinoma

Disease Ontology : ¹² A lung cancer that derives from the distal bronchioles or alveoli that initially exhibit a specific non-invasive growth pattern.

MalaCards based summary : in Situ Pulmonary Adenocarcinoma, also known as bronchioloalveolar adenocarcinoma, is related to bronchiolo-alveolar adenocarcinoma and retroperitoneal leiomyosarcoma, and has symptoms including coughing, dyspnea and fever. An important gene associated with in Situ Pulmonary Adenocarcinoma is LINC02288 (Long Intergenic Non-Protein Coding RNA 2288
LncRNAs such as AK124939 may be anticancer factors related to the progression of pulmonary adenocarcinoma
Dysfunction Pattern: Regulation), and among its related pathways/superpathways are Glioma and Pathways in cancer. Affiliated tissues include lung and thyroid, and related phenotypes are homeostasis/metabolism and mortality/aging

Sources

Related Diseases for in Situ Pulmonary Adenocarcinoma

Diseases related to in Situ Pulmonary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)

#	Related Disease	Score	Top Affiliating Genes
1	bronchiolo-alveolar adenocarcinoma	10.6	EGFR HYAL2
2	retroperitoneal leiomyosarcoma	10.4	PROM1 SMUG1
3	congenital granular cell tumor	10.3	LYZ SERPINA1
4	granulomatous myositis	10.3	LYZ SMUG1
5	laryngeal tuberculosis	10.3	LYZ SMUG1
6	hepatic tuberculosis	10.3	SERPINA1 SMUG1
7	breast lymphoma	10.2	ALK SMUG1
8	gastrointestinal system cancer	10.2	EGFR PROM1 SMUG1
9	diffuse glomerulonephritis	10.1	ESR2 LYZ
10	lymphatic system cancer	10.0	ALK FGF19 LYZ
11	lung papillary adenocarcinoma	10.0	ALK EML4
12	xanthogranulomatous pyelonephritis	9.9	ALK LYZ SMUG1
13	adult lymphoma	9.8	ALK SMUG1
14	lung adenoid cystic carcinoma	9.8	ALK EGFR EML4
15	cutaneous solitary mastocytoma	9.7	LYZ SERPINA1
16	cell type cancer	9.6	ALK EGFR PROM1 SMUG1
17	xanthogranulomatous cholecystitis	9.6	LYZ S100A9 SMUG1
18	adult xanthogranuloma	9.4	LYZ S100A9 SERPINA1
19	respiratory system cancer	9.4	ALK EGFR EML4 SMUG1
20	reticulohistiocytic granuloma	9.4	LYZ S100A9 SERPINA1

Graphical network of the top 20 diseases related to in Situ Pulmonary Adenocarcinoma:

Sources

Symptoms & Phenotypes for in Situ Pulmonary Adenocarcinoma

UMLS symptoms related to in Situ Pulmonary Adenocarcinoma:

coughing, dyspnea, fever, hemoptysis

MGI Mouse Phenotypes related to in Situ Pulmonary Adenocarcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.17	ALK ASPH EGFR ESR2 FGF19 HYAL2
2	mortality/aging	MP:0010768	10.13	ALK ASPH EGFR ESR2 FGF19 HYAL2
3	neoplasm	MP:0002006	9.76	ALK ASPH EGFR ESR2 ITGB1 LYZ
4	nervous system	MP:0003631	9.65	ALK EGFR ESR2 FGF19 ITGB1 LYZ
5	no phenotypic analysis	MP:0003012	9.17	SLC18A3 EGFR ESR2 HYAL2 IL33 LYZ

Sources

Drugs & Therapeutics for in Situ Pulmonary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for in Situ Pulmonary Adenocarcinoma

Sources

Genetic Tests for in Situ Pulmonary Adenocarcinoma

Sources

Anatomical Context for in Situ Pulmonary Adenocarcinoma

MalaCards organs/tissues related to in Situ Pulmonary Adenocarcinoma:

⁴¹

Lung, Thyroid

Sources

Publications for in Situ Pulmonary Adenocarcinoma

Articles related to in Situ Pulmonary Adenocarcinoma:

#	Title	Authors	Year
1	Bronchioloalveolar adenocarcinoma and pulmonary langerhans cell histiocytosis in a patient with MUTYH-associated polyposis. ( 21189386 )	von der ThA1sen J.H....Thunnissen E.	2011
2	A single institution-based retrospective study of surgically treated bronchioloalveolar adenocarcinoma of the lung: clinicopathologic analysis, molecular features, and possible pitfalls in routine practice. ( 20521350 )	Casali C....Morandi U.	2010
3	Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma. ( 18997617 )	Al-Salam S....Al-Ashari M.	2009
4	Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma. ( 15362373 )	Saad R.S....Liu Y.	2004
5	Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies. ( 11554157 )	Goldstein N.S....Thomas M.	2001

Sources

Genes for in Situ Pulmonary Adenocarcinoma

Genes related to in Situ Pulmonary Adenocarcinoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	LINC02288	Long Intergenic Non-Protein Coding RNA 2288 LncRNAs such as AK124939 may be anticancer factors related to the progression of pulmonary adenocarcinoma Dysfunction Pattern: Regulation	RNA Gene	150	Experimental evidence: Regulation ³⁹	25061321
2	ST3GAL5	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5	Protein Coding	15.95	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	BRD3	Bromodomain Containing 3	Protein Coding	15.45	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	HYAL2	Hyaluronoglucosaminidase 2	Protein Coding	15.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ASPH	Aspartate Beta-Hydroxylase	Protein Coding	15.05	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	IL31	Interleukin 31	Protein Coding	14.8	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	FGF19	Fibroblast Growth Factor 19	Protein Coding	14.31	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	EGFR	Epidermal Growth Factor Receptor	Protein Coding	14.27	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	IL33	Interleukin 33	Protein Coding	14.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	ITGB1	Integrin Subunit Beta 1	Protein Coding	13.85	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	13.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	LYZ	Lysozyme	Protein Coding	13.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	PROM1	Prominin 1	Protein Coding	13.44	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	ESR2	Estrogen Receptor 2	Protein Coding	13.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	SLC18A3	Solute Carrier Family 18 Member A3	Protein Coding	13.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	SERPINA1	Serpin Family A Member 1	Protein Coding	13.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	13.2	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
18	MSI1	Musashi RNA Binding Protein 1	Protein Coding	5.43	DISEASES inferred ¹⁵
19	S100A9	S100 Calcium Binding Protein A9	Protein Coding	4.32	DISEASES inferred ¹⁵
20	EML4	Echinoderm Microtubule Associated Protein Like 4	Protein Coding	4.23	DISEASES inferred ¹⁵

Sources

Variations for in Situ Pulmonary Adenocarcinoma

Sources

Expression for in Situ Pulmonary Adenocarcinoma

Search GEO for disease gene expression data for in Situ Pulmonary Adenocarcinoma.

Sources

Pathways for in Situ Pulmonary Adenocarcinoma

Pathways related to in Situ Pulmonary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.22	ALK EGFR EML4 ESR2 FGF19
2	Pathways in cancer ³⁷	11.82	ALK EGFR EML4 ESR2 FGF19 ITGB1
3	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.38	ITGB1 MSI1 PROM1 SERPINA1
4	Signal transduction by L1 ⁶⁶	10.58	EGFR ITGB1

Sources

GO Terms for in Situ Pulmonary Adenocarcinoma

Cellular components related to in Situ Pulmonary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	AP-2 adaptor complex	GO:0030122	8.62	EGFR SLC18A3

Biological processes related to in Situ Pulmonary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	viral entry into host cell	GO:0046718	9.13	EGFR HYAL2 ITGB1
2	positive regulation of inflammatory response	GO:0050729	8.92	EGFR HYAL2 IL33 S100A9

Molecular functions related to in Situ Pulmonary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.43	ALK EGFR ESR2 LYZ MSI1 SERPINA1
2	virus receptor activity	GO:0001618	8.8	EGFR HYAL2 ITGB1

Sources

Sources for in Situ Pulmonary Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia