in Situ Pulmonary Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for in Situ Pulmonary Adenocarcinoma

MalaCards integrated aliases for in Situ Pulmonary Adenocarcinoma:

Name: in Situ Pulmonary Adenocarcinoma ¹² ¹⁵

Bronchioloalveolar Adenocarcinoma ⁷³

Bronchioalveolar Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050870

UMLS ⁷³ C0007120

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Summaries for in Situ Pulmonary Adenocarcinoma

Disease Ontology : ¹² A lung cancer that derives from the distal bronchioles or alveoli that initially exhibit a specific non-invasive growth pattern.

MalaCards based summary : in Situ Pulmonary Adenocarcinoma, also known as bronchioloalveolar adenocarcinoma, is related to congenital granular cell tumor and retroperitoneal leiomyosarcoma, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with in Situ Pulmonary Adenocarcinoma is LINC02288 (Long Intergenic Non-Protein Coding RNA 2288), and among its related pathways/superpathways are Glioma and Pathways in cancer. Affiliated tissues include lung, smooth muscle and kidney, and related phenotypes are homeostasis/metabolism and mortality/aging

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Related Diseases for in Situ Pulmonary Adenocarcinoma

Diseases related to in Situ Pulmonary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)

#	Related Disease	Score	Top Affiliating Genes
1	congenital granular cell tumor	10.1	LYZ SERPINA1
2	retroperitoneal leiomyosarcoma	10.1	PROM1 SMUG1
3	granulomatous myositis	10.1	LYZ SMUG1
4	diffuse glomerulonephritis	10.1	ESR2 LYZ
5	hepatic tuberculosis	10.1	SERPINA1 SMUG1
6	female reproductive system disease	10.0	EGFR ESR2 SMUG1
7	reproductive system disease	10.0	EGFR ESR2 SMUG1
8	gastrointestinal system cancer	10.0	EGFR PROM1 SMUG1
9	lung papillary adenocarcinoma	10.0	ALK EML4
10	lymphatic system cancer	10.0	ALK LYZ SMUG1
11	gastrointestinal system disease	10.0	EGFR SERPINA1 SMUG1
12	lung adenoid cystic carcinoma	9.9	ALK EML4
13	cutaneous solitary mastocytoma	9.9	LYZ SERPINA1
14	pancreas adenocarcinoma	9.9	EGFR PROM1 SMUG1
15	large intestine cancer	9.9	EGFR ESR2 PROM1 SMUG1
16	xanthogranulomatous cholecystitis	9.9	LYZ S100A9 SMUG1
17	adult xanthogranuloma	9.8	LYZ S100A9 SERPINA1
18	reticulohistiocytic granuloma	9.8	LYZ S100A9 SERPINA1
19	respiratory system cancer	9.8	ALK EGFR EML4 SMUG1
20	respiratory system disease	9.5	ALK EGFR EML4 IL33 SERPINA1 SMUG1

Graphical network of the top 20 diseases related to in Situ Pulmonary Adenocarcinoma:

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Symptoms & Phenotypes for in Situ Pulmonary Adenocarcinoma

UMLS symptoms related to in Situ Pulmonary Adenocarcinoma:

fever, dyspnea, hemoptysis, coughing

MGI Mouse Phenotypes related to in Situ Pulmonary Adenocarcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.21	ALK ASPH EGFR ESR2 FGF19 HYAL2
2	mortality/aging	MP:0010768	10.2	ALK ASPH EGFR ESR2 FGF19 HYAL2
3	neoplasm	MP:0002006	9.86	ALK ASPH EGFR ESR2 ITGB1 LYZ
4	nervous system	MP:0003631	9.85	ALK EGFR ESR2 FGF19 ITGB1 LYZ
5	no phenotypic analysis	MP:0003012	9.5	EGFR ESR2 HYAL2 IL33 LYZ PROM1
6	skeleton	MP:0005390	9.23	ALK EGFR ESR2 HYAL2 ITGB1 LYZ

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Drugs & Therapeutics for in Situ Pulmonary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for in Situ Pulmonary Adenocarcinoma

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Genetic Tests for in Situ Pulmonary Adenocarcinoma

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Anatomical Context for in Situ Pulmonary Adenocarcinoma

MalaCards organs/tissues related to in Situ Pulmonary Adenocarcinoma:

⁴¹

Lung, Smooth Muscle, Kidney, Pancreas

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Publications for in Situ Pulmonary Adenocarcinoma

Articles related to in Situ Pulmonary Adenocarcinoma:

#	Title	Authors	Year
1	Bronchioloalveolar adenocarcinoma and pulmonary langerhans cell histiocytosis in a patient with MUTYH-associated polyposis. ( 21189386 )		2011
2	A single institution-based retrospective study of surgically treated bronchioloalveolar adenocarcinoma of the lung: clinicopathologic analysis, molecular features, and possible pitfalls in routine practice. ( 20521350 )	Casali C....Morandi U.	2010
3	Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma. ( 15362373 )	Saad R.S....Liu Y.	2004
4	Is high-grade adenomatous hyperplasia an early bronchioloalveolar adenocarcinoma? ( 14595748 )	Ullmann R...Popper HH	2003
5	Early results of a prospective study of limited resection for bronchioloalveolar adenocarcinoma of the lung. ( 11269483 )	Yamato Y...Hayashi J	2001
6	Expression of alpha-smooth muscle actin in small bronchioloalveolar adenocarcinoma of the lung: assessment and comparison with noguchi criteria. ( 10523684 )	Sato M...Tanaka S	1999
7	Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease. ( 9808126 )	Holst VA...Yousem SA	1998
8	Bronchioloalveolar adenocarcinoma with myoepithelial cells. ( 1849448 )	Dekmezian R...Mackay B	1991

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Genes for in Situ Pulmonary Adenocarcinoma

Genes related to in Situ Pulmonary Adenocarcinoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	LINC02288	Long Intergenic Non-Protein Coding RNA 2288	RNA Gene	150	Experimental evidence: Regulation ³⁹	25061321
2	ST3GAL5	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5	Protein Coding	15.83	DISEASES inferred ¹⁵
3	BRD3	Bromodomain Containing 3	Protein Coding	15.34	DISEASES inferred ¹⁵
4	HYAL2	Hyaluronidase 2	Protein Coding	15.26	DISEASES inferred ¹⁵
5	ASPH	Aspartate Beta-Hydroxylase	Protein Coding	14.88	DISEASES inferred ¹⁵
6	IL31	Interleukin 31	Protein Coding	14.71	DISEASES inferred ¹⁵
7	FGF19	Fibroblast Growth Factor 19	Protein Coding	14.19	DISEASES inferred ¹⁵
8	EGFR	Epidermal Growth Factor Receptor	Protein Coding	14.08	DISEASES inferred ¹⁵
9	IL33	Interleukin 33	Protein Coding	13.86	DISEASES inferred ¹⁵
10	ITGB1	Integrin Subunit Beta 1	Protein Coding	13.72	DISEASES inferred ¹⁵
11	LYZ	Lysozyme	Protein Coding	13.46	DISEASES inferred ¹⁵
12	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	13.36	DISEASES inferred ¹⁵
13	SLC18A3	Solute Carrier Family 18 Member A3	Protein Coding	13.33	DISEASES inferred ¹⁵
14	ESR2	Estrogen Receptor 2	Protein Coding	13.25	DISEASES inferred ¹⁵
15	PROM1	Prominin 1	Protein Coding	13.25	DISEASES inferred ¹⁵
16	SERPINA1	Serpin Family A Member 1	Protein Coding	13.16	DISEASES inferred ¹⁵
17	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	13	DISEASES inferred ¹⁵
18	MSI1	Musashi RNA Binding Protein 1	Protein Coding	5.23	DISEASES inferred ¹⁵
19	S100A9	S100 Calcium Binding Protein A9	Protein Coding	4.25	DISEASES inferred ¹⁵
20	EML4	Echinoderm Microtubule Associated Protein Like 4	Protein Coding	3.95	DISEASES inferred ¹⁵

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Variations for in Situ Pulmonary Adenocarcinoma

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Expression for in Situ Pulmonary Adenocarcinoma

Search GEO for disease gene expression data for in Situ Pulmonary Adenocarcinoma.

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Pathways for in Situ Pulmonary Adenocarcinoma

Pathways related to in Situ Pulmonary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.22	ALK EGFR EML4 ESR2 FGF19
2	Pathways in cancer ³⁷	11.82	ALK EGFR EML4 ESR2 FGF19 ITGB1
3	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.38	ITGB1 MSI1 PROM1 SERPINA1
4	Signal transduction by L1 ⁶⁶	10.58	EGFR ITGB1

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GO Terms for in Situ Pulmonary Adenocarcinoma

Biological processes related to in Situ Pulmonary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	viral entry into host cell	GO:0046718	9.13	EGFR HYAL2 ITGB1
2	positive regulation of inflammatory response	GO:0050729	8.92	EGFR HYAL2 IL33 S100A9

Molecular functions related to in Situ Pulmonary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.43	ALK EGFR ESR2 LYZ MSI1 SERPINA1
2	virus receptor activity	GO:0001618	8.8	EGFR HYAL2 ITGB1

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Sources for in Situ Pulmonary Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia