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SIADH
MCID: INP001
MIFTS: 47

Inappropriate Adh Syndrome (SIADH)

Categories: Endocrine diseases
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Aliases & Classifications for Inappropriate Adh Syndrome

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MalaCards integrated aliases for Inappropriate Adh Syndrome:

Name: Inappropriate Adh Syndrome 11 43 14 16 71
Syndrome of Inappropriate Secretion of Antidiuretic Hormone 11 31 33
Syndrome of Inappropriate Antidiuretic Hormone Secretion 11 75 33
Syndrome of Inappropriate Vasopressin Secretion 11 33
Siadh 11 53
Siadh - [syndrome of Inappropriate Secretion of Antidiuretic Hormone] 33
Hormone Secretion; Inadequate Antidiuretic Hormone Secretion Syndrome 33
Inappropriate Secretion of Antidiuretic Hormone 33
Siad - [syndrome of Inappropriate Antidiuresis] 33
Syndrome of Inappropriate Secretion of Adh 11
Syndrome of Inappropriate Antidiuresis 33
Hypersecretion of Antidiuretic Hormone 33
Antidiuretic Hormone Syndrome 33
Schwartz-Bartter Syndrome 33

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:3401
MeSH 43 D007177
NCIt 49 C3988
SNOMED-CT 68 55004003
ICD10 31 E22.2
UMLS 71 C0021141
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Summaries for Inappropriate Adh Syndrome

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Disease Ontology: 11 A pituitary gland disease resulting from excessive production of antidiuretic hormone (ADH).

MalaCards based summary: Inappropriate Adh Syndrome, also known as syndrome of inappropriate secretion of antidiuretic hormone, is related to nephrogenic syndrome of inappropriate antidiuresis and dipsogenic diabetes insipidus, and has symptoms including polyuria An important gene associated with Inappropriate Adh Syndrome is AVP (Arginine Vasopressin), and among its related pathways/superpathways are G alpha (s) signalling events and Glucocorticoid receptor regulatory network. The drugs Empagliflozin and Sodium-Glucose Transporter 2 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and lung, and related phenotypes are renal/urinary system and homeostasis/metabolism

Wikipedia: 75 Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive... more...
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Related Diseases for Inappropriate Adh Syndrome

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Diseases related to Inappropriate Adh Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1057)
# Related Disease Score Top Affiliating Genes
1 nephrogenic syndrome of inappropriate antidiuresis 32.3 OXT AVPR2 AVP AQP2
2 dipsogenic diabetes insipidus 30.8 AVPR2 AVP AQP2
3 neuromyelitis optica 30.7 IL6 CRP AQP4
4 myxedema 30.7 POMC NPPA AVP ALB
5 cavernous sinus thrombosis 30.7 POMC CRP
6 premature ovarian failure 7 30.7 POMC CRH
7 pituitary hormone deficiency, combined, 2 30.6 PRL POMC AVP
8 lung oat cell carcinoma 30.5 POMC ENO2 AVP
9 heart septal defect 30.5 NPPB NPPA CRP
10 normal pressure hydrocephalus 30.5 CRH AQP4 ALB
11 small cell cancer of the lung 30.4 POMC ENO2 AVP
12 whipple disease 30.4 LGI1 CRP ALB
13 acth deficiency, isolated 30.4 PRL POMC CRH
14 metabolic acidosis 30.4 REN IL6 AQP2 ALB
15 hypothalamic disease 30.3 PRL POMC CRH AVP
16 hyperuricemia 30.3 REN CRP ALB
17 bartter disease 30.3 REN AVPR2 AVP AQP2
18 sheehan syndrome 30.3 PRL POMC CRH AVP
19 amenorrhea 30.2 PRL POMC OXT CRH
20 polycystic kidney disease 1 with or without polycystic liver disease 30.2 REN AQP2 ACE
21 pleural empyema 30.2 IL6 CRP ALB
22 cholangitis 30.2 IL6 CRP ALB
23 central diabetes insipidus 30.2 PRL POMC OXT AVPR2 AVP AQP2
24 lung abscess 30.1 IL6 CRP ALB
25 bacterial pneumonia 30.1 IL6 CRP ALB
26 transverse myelitis 30.0 LGI1 IL6 CRP AQP4
27 hypoaldosteronism 29.9 REN POMC NPPA ACE
28 restrictive cardiomyopathy 29.9 REN NPPB CRP ACE
29 hypokalemia 29.9 REN POMC CRH AVPR2 AVP AQP2
30 pituitary gland disease 29.9 PRL POMC CRH AVPR2 AVP
31 diarrhea 29.9 REN IL6 CYP3A4 ALB
32 adenoma 29.8 REN PRL POMC CRH
33 neurosarcoidosis 29.8 LGI1 CRP AQP4 ACE
34 neurotic disorder 29.8 POMC OXT IL6 CRP CRH
35 hypopituitarism 29.8 PRL POMC IL6 CRP CRH
36 diabetes insipidus, neurohypophyseal 29.8 REN POMC OXT AVPR2 AVP AQP2
37 pancytopenia 29.8 IL6 CRP ALB ACE
38 hypoadrenocorticism, familial 29.8 REN POMC CRH
39 pulmonary tuberculosis 29.8 IL6 CRP ALB
40 pituitary apoplexy 29.8 PRL POMC IL6 AVP
41 fibromyalgia 29.7 POMC OXT IL6 CRP CRH
42 acquired immunodeficiency syndrome 29.7 POMC IL6 CRP CRH ALB
43 pure autonomic failure 29.7 REN NPPA ACE
44 graves disease 1 29.7 POMC CRP ALB
45 functioning pituitary adenoma 29.7 PRL POMC CRH
46 alcohol dependence 29.7 POMC CRH AVP ALB ACE
47 neutropenia 29.6 IL6 CYP3A4 CRP ALB
48 central pontine myelinolysis 29.6 REN POMC AVPR2 AVP AQP4 AQP2
49 meningoencephalitis 29.6 IL6 CRP ALB
50 lyme disease 29.6 IL6 ENO2 CRP

Graphical network of the top 20 diseases related to Inappropriate Adh Syndrome:



Diseases related to Inappropriate Adh Syndrome
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Symptoms & Phenotypes for Inappropriate Adh Syndrome

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UMLS symptoms related to Inappropriate Adh Syndrome:


polyuria

GenomeRNAi Phenotypes related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.13 ACE ALB AQP2 AQP4 AVP AVPR2
2 no effect GR00402-S-2 10.13 ACE ALB AQP2 AQP4 AVPR2 CRH

MGI Mouse Phenotypes related to Inappropriate Adh Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 10.03 ACE ALB AQP2 AQP4 AVP AVPR2
2 homeostasis/metabolism MP:0005376 10.03 ACE ALB AQP2 AQP4 AVP AVPR2
3 cardiovascular system MP:0005385 9.65 ACE ALB AQP4 CRP IL6 NPPA
4 behavior/neurological MP:0005386 9.44 ACE AQP2 AQP4 AVP AVPR2 CRH
Sources

Drugs & Therapeutics for Inappropriate Adh Syndrome

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Drugs for Inappropriate Adh Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Empagliflozin Approved Phase 4 864070-44-0 73151030 11949646
2 Sodium-Glucose Transporter 2 Inhibitors Phase 4
3 Hypoglycemic Agents Phase 4
4
Satavaptan Investigational Phase 3 185913-78-4 158348
5 Pharmaceutical Solutions Phase 2, Phase 3
6 Deamino Arginine Vasopressin Phase 2, Phase 3
7
Carbamide peroxide Approved Phase 2 124-43-6
8
Fludrocortisone Approved, Investigational 127-31-1 31378
9 Antipsychotic Agents
10 Psychotropic Drugs
11 Tea
12 diuretics

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia - a Multicentric Randomized Double-blind Placebo-controlled Trial (the EMPOWER Study) Recruiting NCT04447911 Phase 4 Empagliflozin 25 MG;Placebo
2 Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-secretion Caused by Treatment With Antiepileptic Medicine Withdrawn NCT00298753 Phase 4
3 Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study Completed NCT02729766 Phase 2, Phase 3 Empagliflozin 25mg Tbl;Placebo P-Tablet
4 A Multicenter, Uncontrolled, Open-label, Dose-titration Trial to Investigate the Efficacy and Safety of Tolvaptan Tablets in Patients With Hyponatremia in Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Completed NCT03048747 Phase 3 Tolvaptan Oral Tablet
5 Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study Completed NCT03202667 Phase 2, Phase 3 Empagliflozin 25mg;Placebo
6 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia Completed NCT00072683 Phase 3 tolvaptan
7 A Randomized, Double-Blind, Placebo-Group, Multicenter Study Evaluating the Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264927 Phase 3 SR121463B
8 Multicenter, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia, Study 2 Completed NCT00201994 Phase 3 Tolvaptan
9 An Open-Label, Multicenter Study Evaluating the Long-Term Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264914 Phase 3 SR121463B
10 Effects of the SGLT2-inhibitor Empagliflozin on Patients With SIADH - the SAND Study Completed NCT02874807 Phase 2, Phase 3 Empagliflozin
11 A Double-Blind, Randomized, Placebo-Controlled Multicenter Study Evaluating the Efficacy and Safety of Two Doses of Satavaptan (SR121463B) Versus Placebo in Patients With Dilutional Hyponatremia Due to the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Terminated NCT00728091 Phase 3 Satavaptan;placebo
12 Phase 3b, Multicenter, Randomized, Single-blind, Parallel Group Trial of the Effects of Titrated Oral SAMSCA(r) (Tolvaptan) 15, 30, or 60 mg QD Compared to Placebo Plus Fluid Restriction on Length of Hospital Stay and Symptoms in Subjects Hospitalized With Dilutional Hyponatremia Terminated NCT01227512 Phase 3 tolvaptan
13 A Phase 1b, Multicenter, Pilot, Randomized, Double-blind Trial to Determine the Pharmacokinetics and Pharmacodynamics of Orally Administered Tolvaptan 3.75, 7.5, and 15 mg Tablets in Subjects With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT02009878 Phase 1, Phase 2 tolvaptan
14 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Escalation, Multicenter Study Evaluating the Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion. Completed NCT00032734 Phase 2 satavaptan (SR121463B)
15 Urea for Chronic Hyponatremia: A Pilot Study Recruiting NCT04588207 Phase 2 Urea
16 A Multi-Centre, Multi-National, Observational Post-Authorisation Safety Study to Document the Drug Utilisation of Samsca and to Collect Information on the Safety of Samsca When Used in Routine Medical Practice Unknown status NCT01228682 Tolvaptan
17 Is Hyponatraemia a Risk Factor for Mortality in Schizophrenic and Bipolar Patients? Protocol for a Bayesian Causal Inference Study Unknown status NCT04409626
18 Observational Cohort Study- The Clinical and Laboratory Characteristics of Recurrent Drug- Related Unknown status NCT01509170
19 Comparison of the Vasopressin-2 Antagonist Tolvaptan and Fluid Restriction in the Treatment of Hyponatremia Following Pituitary Surgery Completed NCT04119206
20 Standardization of Fluids in Inpatient Settings Completed NCT03924674
21 A Prospective, Observational Study Measuring Sodium Improvement and Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia Secondary to SIADH in Italy Completed NCT02573077
22 Water Load Test Value for Hyponatremia Due to a Syndrome of Inappropriate Antidiuresis (SIAD) Completed NCT04256499
23 A Non Interventional, Retrospective Study on Real World Usage and Treatment Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to the SIADH. Completed NCT02545101
24 An Observational, Retrospective Study to Describe the Extent of Adherence to the Spanish Society of Medical Oncology Algorithm for the Treatment of Hyponatraemia Secondary to SIADH in Oncology Patients in Spain (ALGA) Completed NCT02548845
25 Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH? Completed NCT01341665
26 Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia Completed NCT04744987
27 Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in Japan Recruiting NCT04790175 Tolvaptan (SAMSCA)
28 Effect of Protein Supplementation on Plasma Sodium Levels and Urinary Urea Excretion in Patients With SIAD - a Monocentric Open- Label Proof-of-concept Study -The TREASURE Study Recruiting NCT04987385
29 Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage Recruiting NCT04552873 Urea
30 Asymptomatic Bacteriuria, Hyponatremia and Geri-atric Syndrome Recruiting NCT05055856
31 Use of Tolvaptan to Treat SIADH-induced Hyponatremia in Selected Patients With Acute Neurological Injuries Terminated NCT02545114 Tolvaptan
32 Study of Nonedematous Hyponatremia and the Utility of Fractional Urate Excretion in Hyponatremia and Suspected Renal Salt Wasting Without Hyponatremia- Withdrawn NCT01425125 Tolvaptan in euvolemic hyponatremia

Search NIH Clinical Center for Inappropriate Adh Syndrome

Cochrane evidence based reviews: inappropriate adh syndrome

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Genetic Tests for Inappropriate Adh Syndrome

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Anatomical Context for Inappropriate Adh Syndrome

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Organs/tissues related to Inappropriate Adh Syndrome:

MalaCards : Pituitary, Kidney, Lung, Brain, Prostate, Bone Marrow, Liver
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Publications for Inappropriate Adh Syndrome

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Articles related to Inappropriate Adh Syndrome:

(show top 50) (show all 3012)
# Title Authors PMID Year
1
Hyponatremia and brain injury: absence of alterations of serum brain natriuretic peptide and vasopressin. 53 62
20069215 2009
2
[Hyponatraemia in patients with neurosurgical disorders: SIADH or cerebral salt wasting syndrome?]. 53 62
19885796 2009
3
Intermittent severe, symptomatic hyponatraemia due to the nephrogenic syndrome of inappropriate antidiuresis. 53 62
18753429 2008
4
Severe paraneoplastic hyponatremia and hypoosmolality in a patient with small-cell lung carcinoma: syndrome of inappropriate antidiuretic hormone secretion versus atrial natriuretic peptide or both? 53 62
17562242 2007
5
A rare case of combined syndrome of inappropriate antidiuretic hormone secretion and Fanconi syndrome in an elderly woman. 53 62
16797399 2006
6
Atrial natriuretic peptide in children with pneumonia. 53 62
15830390 2005
7
Hypothalamic-pituitary-adrenal axis and interleukin-6 activity in children with head trauma and syndrome of inappropriate secretion of antidiuretic hormone. 53 62
12585340 2003
8
Aquaporins in the kidney: from molecules to medicine. 53 62
11773613 2002
9
Physiology and pathophysiology of renal aquaporins. 53 62
11320486 2001
10
Close association of urinary excretion of aquaporin-2 with appropriate and inappropriate arginine vasopressin-dependent antidiuresis in hyponatremia in elderly subjects. 53 62
11297601 2001
11
[New players in the physiopathology of water metabolism: the aquaporins]. 53 62
10667046 1999
12
[Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. 53 62
10614173 1999
13
Syndrome of inappropriate antidiuretic hormone secretion in children following spinal fusion. 53 62
10199545 1999
14
Long-term regulation of urinary concentrating capacity. 53 62
9729504 1998
15
Acute aquaresis by the nonpeptide arginine vasopressin (AVP) antagonist OPC-31260 improves hyponatremia in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). 53 62
9100572 1997
16
Pathogenesis of hyponatremia following subarachnoid hemorrhage due to ruptured cerebral aneurysm. 53 62
8874554 1996
17
Early diagnosis of ectopic arginine vasopressin secretion. 53 62
8380364 1993
18
Ectopic atrial natriuretic peptide production in small cell lung cancer with the syndrome of inappropriate antidiuretic hormone secretion. 53 62
1655209 1991
19
[Syndrome of inappropriate ADH secretion (SIADH) in small-cell bronchus carcinoma]. 53 62
1656520 1991
20
A case of syndrome of inappropriate secretion of antidiuretic hormone associated with diabetes mellitus. 53 62
1794339 1991
21
Corticotropin deficiency: a rare cause of hyponatremia mimicking SIADH. 53 62
1648196 1991
22
Atrial natriuretic peptide in patients with the syndrome of inappropriate antidiuretic hormone secretion and with diabetes insipidus. 53 62
2139879 1990
23
Hyponatremia with Antidepressant: A Rare Side Effect from Duloxetine in a Child with Acute Leukemia. 62
35537479 2022
24
Exoscopic vs. microscopic transsphenoidal surgery for Cushing's disease: a retrospective single-center study on 388 patients. 62
36136255 2022
25
Idiopathic SIADH: 4 years of diagnostic wandering. 62
36094565 2022
26
Human herpesvirus 6 (HHV-6) associated permanent hyponatremia in umbilical cord blood transplant recipient. 62
36372142 2022
27
Whole Exome Sequencing Identifies PHF14 Mutations in Neurocytoma and Predicts Responsivity to the PDGFR Inhibitor Sunitinib. 62
36359362 2022
28
A 43-Day-Old Male With Respiratory Distress and Acute-Onset Hypotonia. 62
36254627 2022
29
Starting point for benchmarking outcomes and reporting of pituitary adenoma surgery within the European Reference Network on Rare Endocrine Conditions (Endo-ERN): results from a meta-analysis and survey study. 62
36327151 2022
30
Paraneoplastic syndromes: A focus on pathophysiology and supportive care. 62
35916756 2022
31
Syndrome of inappropriate antidiuresis and diabetes insipidus as two sides of the same coin in hypothalamic lymphoma: A case report. 62
36424791 2022
32
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1. 62
36420541 2022
33
Oncologic emergencies and urgencies: A comprehensive review. 62
35653456 2022
34
Korean Society of Nephrology 2022 recommendations on controversial issues in diagnosis and management of hyponatremia. 62
36245341 2022
35
Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. 62
36396331 2022
36
Hyponatremia-related liver steatofibrosis and impaired spermatogenesis: evidence from a mouse model of the syndrome of inappropriate antidiuresis. 62
36436190 2022
37
Effect of vasopressin V2-receptor antagonist tolvaptan on syndrome of inappropriate antidiuresis (SIAD) after transsphenoidal pituitary surgery: recovery of measured osmolality. 62
36247169 2022
38
Hyperlactatemia and other perioperative metabolic disturbances in neuroanesthesia. 62
35942723 2022
39
Approach to the patient - disorders of salt and water balance post pituitary surgery. 62
36300330 2022
40
Hyponatremia Associated With Standard-Dose Trimethoprim-Sulfamethoxazole Use in an Immunocompetent Patient. 62
36301661 2022
41
Hyponatremia in the emergency department. 62
35870366 2022
42
Syndrome of inappropriate secretion of antidiuretic hormone after total proctocolectomy for ulcerative colitis. 62
36280658 2022
43
Endocrine Disorders in Children with Brain Tumors: At Diagnosis, after Surgery, Radiotherapy and Chemotherapy. 62
36360345 2022
44
Miller Fisher syndrome complicated by inappropriate secretion of antidiuretic hormone: a case report. 62
35871211 2022
45
The Incidence and Risk Factors of Hyponatremia in Pulmonary Tuberculosis. 62
36249414 2022
46
Hyponatremia in COVID-19 Is Not Always Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH): A Case Series. 62
36465769 2022
47
Duck or Rabbit? Cerebral Salt Wasting and SIADH in Acute Brain Injury. 62
36316566 2022
48
Lymphocytic Hypophysitis in a Patient With Suspected Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH). 62
36397915 2022
49
A Tick-Borne Cause of Hyponatremia: SIADH Due to Lyme Meningitis. 62
35636484 2022
50
Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature. 62
35188820 2022
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Variations for Inappropriate Adh Syndrome

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Expression for Inappropriate Adh Syndrome

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Search GEO for disease gene expression data for Inappropriate Adh Syndrome.
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Pathways for Inappropriate Adh Syndrome

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Pathways related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 66
Show member pathways
 11.66 POMC CRH AVPR2 AVP
2
Glucocorticoid receptor regulatory network 61
11.38 PRL POMC IL6
3
Aquaporin-mediated transport 66
Show member pathways
 11.3 AVPR2 AVP AQP4 AQP2
4
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10.1 POMC CRH
5
Vasopressin-like receptors 66
Show member pathways
 9.84 OXT AVPR2 AVP
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GO Terms for Inappropriate Adh Syndrome

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Cellular components related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 ACE ALB AQP4 AVP CRH CRP
2 extracellular space GO:0005615 9.77 ACE ALB AVP CRH CRP ENO2

Biological processes related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of vasoconstriction GO:0045907 9.95 AVPR2 AVP ACE
2 water transport GO:0006833 9.91 AVP AQP4 AQP2
3 vasoconstriction GO:0042310 9.85 CRP AVP ACE
4 negative regulation of renal sodium excretion GO:0035814 9.81 AVPR2 ACE
5 regulation of vascular endothelial growth factor production GO:0010574 9.8 IL6 AQP4
6 positive regulation of systemic arterial blood pressure GO:0003084 9.8 ACE AVP AVPR2
7 maternal aggressive behavior GO:0002125 9.76 OXT AVP
8 hyperosmotic salinity response GO:0042538 9.73 OXT AVP AQP4
9 positive regulation of blood pressure GO:0045777 9.71 OXT AVPR2 ACE
10 negative regulation of urine volume GO:0035811 9.7 OXT AVPR2
11 regulation of blood pressure GO:0008217 9.65 REN POMC NPPB NPPA ACE
12 blood vessel diameter maintenance GO:0097746 9.63 NPPB NPPA AVP ACE
13 female pregnancy GO:0007565 9.4 PRL OXT NPPA CRH AQP4 ACE

Molecular functions related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.83 AVP CRH IL6 LGI1 NPPA NPPB
2 neuropeptide hormone activity GO:0005184 9.76 OXT NPPA CRH AVP
3 hormone receptor binding GO:0051427 9.62 NPPB NPPA
4 neurohypophyseal hormone activity GO:0005185 9.56 OXT AVP
5 hormone activity GO:0005179 9.4 PRL POMC OXT NPPB NPPA CRH
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Sources for Inappropriate Adh Syndrome

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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