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MCID: INP001
MIFTS: 47

Inappropriate Adh Syndrome

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Inappropriate Adh Syndrome

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MalaCards integrated aliases for Inappropriate Adh Syndrome:

Name: Inappropriate Adh Syndrome 12 45 15 17 74
Syndrome of Inappropriate Secretion of Antidiuretic Hormone 12 38
Syndrome of Inappropriate Antidiuretic Hormone Secretion 12
Syndrome of Inappropriate Vasopressin Secretion 12
Syndrome of Inappropriate Secretion of Adh 12

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:3401
KEGG 38 H01682
MeSH 45 D007177
NCIt 51 C3988
SNOMED-CT 69 55004003
ICD10 34 E22.2
UMLS 74 C0021141
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Summaries for Inappropriate Adh Syndrome

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MalaCards based summary : Inappropriate Adh Syndrome, also known as syndrome of inappropriate secretion of antidiuretic hormone, is related to nephrogenic syndrome of inappropriate antidiuresis and syndrome of inappropriate antidiuretic hormone, and has symptoms including polyuria An important gene associated with Inappropriate Adh Syndrome is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Vasopressin-regulated water reabsorption. The drugs Tolvaptan and Empagliflozin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and prostate, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 77 Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive... more...

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Related Diseases for Inappropriate Adh Syndrome

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Diseases related to Inappropriate Adh Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 nephrogenic syndrome of inappropriate antidiuresis 32.6 AVP AVPR2
2 syndrome of inappropriate antidiuretic hormone 32.6 AQP2 AVP AVPR2 POMC
3 lung oat cell carcinoma 30.7 AVP POMC
4 bronchus cancer 30.5 AVP POMC
5 liver cirrhosis 30.0 AQP2 AVP REN
6 hypokalemia 30.0 AQP2 POMC REN
7 diabetes insipidus 29.9 AQP2 AVP AVPR2 POMC REN
8 lymphoma 10.6
9 lung cancer 10.5
10 lupus erythematosus 10.5
11 olfactory neuroblastoma 10.5
12 herpes zoster 10.5
13 systemic lupus erythematosus 10.4
14 neuroendocrine carcinoma 10.4
15 prostate cancer 10.4
16 small cell cancer of the lung 10.4
17 prostate cancer, hereditary, 8 10.4
18 prostate cancer, hereditary, 6 10.4
19 squamous cell carcinoma 10.4
20 meningitis 10.4
21 brucellosis 10.3
22 breast cancer 10.3
23 neuromyelitis optica 10.3
24 neuromyelitis optica spectrum disorder 10.3
25 tuberculous meningitis 10.3
26 diabetes insipidus, nephrogenic, x-linked 10.3 AQP2 AVPR2
27 peripheral vertigo 10.3 AQP2 AVP
28 vestibular disease 10.3 AQP2 AVP
29 central nervous system germinoma 10.2 AVP POMC
30 myeloma, multiple 10.2
31 suppression of tumorigenicity 12 10.2
32 cystadenoma 10.2
33 lateral medullary syndrome 10.2
34 craniopharyngioma 10.2
35 status asthmaticus 10.2
36 tuberculous epididymitis 10.2 AVP POMC
37 central nervous system germ cell tumor 10.2 AVP POMC
38 porphyria, acute intermittent 10.2
39 schizophrenia 10.2
40 neuroblastoma 1 10.2
41 thymoma, familial 10.2
42 brain injury 10.2
43 diabetes mellitus 10.2
44 small cell carcinoma 10.2
45 porphyria 10.2
46 melanoma 10.2
47 adenocarcinoma 10.2
48 thymoma 10.2
49 herpes zoster ophthalmicus 10.2
50 olfactory nerve neoplasm 10.2 AVP POMC

Graphical network of the top 20 diseases related to Inappropriate Adh Syndrome:



Diseases related to Inappropriate Adh Syndrome
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Symptoms & Phenotypes for Inappropriate Adh Syndrome

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UMLS symptoms related to Inappropriate Adh Syndrome:


polyuria

MGI Mouse Phenotypes related to Inappropriate Adh Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 AQP2 AQP4 AVP AVPR2 CNTNAP2 POMC
2 growth/size/body region MP:0005378 9.8 AQP2 AQP4 AVPR2 CNTNAP2 POMC REN
3 mortality/aging MP:0010768 9.7 AQP2 AQP4 AVP AVPR2 POMC REN
4 nervous system MP:0003631 9.43 AQP4 AVP CNTNAP2 POMC REN SNAI1
5 renal/urinary system MP:0005367 9.1 AQP2 AQP4 AVP AVPR2 POMC REN
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Drugs & Therapeutics for Inappropriate Adh Syndrome

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Drugs for Inappropriate Adh Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tolvaptan Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 150683-30-0 216237
2
Empagliflozin Approved Phase 2, Phase 3,Phase 3 864070-44-0
3
Satavaptan Investigational Phase 3,Phase 2 185913-78-4 7029
4 Hormones Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
5 Natriuretic Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
6 Arginine Vasopressin Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
7 Vasopressins Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
8 Antidiuretic Hormone Receptor Antagonists Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
9 Vasoconstrictor Agents Phase 3,Phase 2,Phase 1
10 Hemostatics Phase 3,Phase 2,Phase 1
11 Hormone Antagonists Phase 3,Phase 2,Phase 1
12 Coagulants Phase 3,Phase 2,Phase 1
13 arginine Phase 3,Phase 2,Phase 1
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
15 Sodium-Glucose Transporter 2 Inhibitors Phase 2, Phase 3,Phase 3
16 Hypoglycemic Agents Phase 2, Phase 3,Phase 3
17 Pharmaceutical Solutions Phase 2, Phase 3
18 Deamino Arginine Vasopressin Phase 2, Phase 3
19
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
20
Probenecid Approved, Investigational Phase 1, Phase 2 57-66-9 4911
21 Free Radical Scavengers Phase 1, Phase 2
22 Antiviral Agents Phase 1, Phase 2
23 Antidotes Phase 1, Phase 2
24 Respiratory System Agents Phase 1, Phase 2
25 Expectorants Phase 1, Phase 2
26 cysteine Phase 1, Phase 2
27 Anti-Infective Agents Phase 1, Phase 2
28 Renal Agents Phase 1, Phase 2
29 Antirheumatic Agents Phase 1, Phase 2
30 Antioxidants Phase 1, Phase 2
31 N-monoacetylcystine Phase 1, Phase 2
32 Protective Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-secretion Caused by Treatment With Antiepileptic Medicine Withdrawn NCT00298753 Phase 4
2 Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia Unknown status NCT01507727 Phase 2, Phase 3 Tolvaptan;Placebo
3 Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264914 Phase 3 SR121463B
4 Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264927 Phase 3 SR121463B
5 Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study Completed NCT02729766 Phase 2, Phase 3 Empagliflozin 25mg Tbl;Placebo P-Tablet
6 Effects of the SGLT2-inhibitor Empagliflozin on Patients With SIADH - the SAND Study Completed NCT02874807 Phase 2, Phase 3 Empagliflozin
7 "SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia Completed NCT00201994 Phase 3 Tolvaptan
8 “SALT Trial” Study of Ascending Levels of Tolvaptan in Hyponatremia Completed NCT00072683 Phase 3 tolvaptan
9 A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremia in SIADH Recruiting NCT03048747 Phase 3 Tolvaptan Oral Tablet
10 Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study Recruiting NCT03202667 Phase 2, Phase 3 Empagliflozin 25mg;Placebo
11 A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia Terminated NCT00728091 Phase 3 Satavaptan;placebo
12 Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia Terminated NCT01227512 Phase 3 tolvaptan
13 Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00032734 Phase 2 satavaptan (SR121463B)
14 A PK Study of 3 Dosages of Tolvaptan in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Completed NCT02009878 Phase 1, Phase 2 tolvaptan
15 Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury Completed NCT01322009 Phase 1, Phase 2 Probenecid and N-acetyl cysteine;Placebo
16 Subclassification of the Syndrome of Inappropriate ADH Secretion Completed NCT01341665
17 An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to SIADH Completed NCT02545101
18 An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in Spain Completed NCT02548845
19 An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy Completed NCT02573077
20 Hyponatremia Registry for Patients With Euvolemic and Hypervolemic Hyponatremia Completed NCT01240668
21 SOFI: A Quality Improvement Project to Standardize Use of Intravenous Fluids in Hospitalized Pediatric Patients Active, not recruiting NCT03924674 Not Applicable
22 Evaluation of Plasma Volume Using Ultrasound in Disorders of Fluid With Sodium Active, not recruiting NCT01547650
23 Fractional Urate Excretion in Nonedematous Hyponatremia Withdrawn NCT01425125 Not Applicable Tolvaptan in euvolemic hyponatremia

Search NIH Clinical Center for Inappropriate Adh Syndrome

Cochrane evidence based reviews: inappropriate adh syndrome

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Genetic Tests for Inappropriate Adh Syndrome

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Anatomical Context for Inappropriate Adh Syndrome

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MalaCards organs/tissues related to Inappropriate Adh Syndrome:

42
Pituitary, Kidney, Prostate, Lung, Brain, Liver, B Cells
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Publications for Inappropriate Adh Syndrome

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Articles related to Inappropriate Adh Syndrome:

(show top 50) (show all 290)
# Title Authors Year
1
A rare iatrogenic association of syndrome of inappropriate secretion of antidiuretic hormone, neuroleptic malignant syndrome and rhabdomyolysis. ( 30949348 )
2019
2
A case report of a thymic neuroblastoma associated with syndrome of inappropriate secretion of antidiuretic hormone: Ten-year follow-up results after surgical treatment. ( 31005046 )
2019
3
Syndrome of inappropriate secretion of antidiuretic hormone associated with angiotensin-converting enzyme inhibitor therapy in the perioperative period. ( 30843458 )
2019
4
A Case of Neurosarcoidosis-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone Diagnosed with Neuroendoscopy. ( 30158982 )
2018
5
Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Hyponatremia. ( 29292284 )
2018
6
Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan. ( 29478867 )
2018
7
Tolvaptan for the Syndrome of Inappropriate Secretion of Antidiuretic Hormone: Is the Dose Too High? ( 29801549 )
2018
8
Severe Solute Depletion in Patients with Hyponatremia Due to Diuretics Despite Biochemical Pictures Similar Than Those Observed in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone. ( 29990986 )
2018
9
Determining Fractional Urate Excretion Rates in Hyponatremic Conditions and Improved Methods to Distinguish Cerebral/Renal Salt Wasting From the Syndrome of Inappropriate Secretion of Antidiuretic Hormone. ( 30560127 )
2018
10
A case of a cerebral cavernous malformation of the third ventricle that caused the syndrome of inappropriate secretion of antidiuretic hormone. ( 28540119 )
2017
11
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Preceding Guillain-Barré Syndrome. ( 29207765 )
2017
12
Localized herpes zoster infection: a rare cause of syndrome of inappropriate secretion of antidiuretic hormone. ( 29230301 )
2017
13
Refractory Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Systemic Lupus Erythematosus-associated Hypophysitis. ( 28604351 )
2017
14
Successful Radiotherapy for Advanced Small Cell Carcinoma of the Prostate with Syndrome of Inappropriate Secretion of Antidiuretic Hormone. ( 28567332 )
2017
15
Mild Lung Tuberculosis in a Patient Suffering from Status Epilepticus Caused by the Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH). ( 28202866 )
2017
16
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient. ( 28271051 )
2017
17
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) due to bortezomib in a case of light chain multiple mieloma. Treatment with tolvaptan. ( 28946972 )
2017
18
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. ( 27461339 )
2016
19
Erratum to: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. ( 27716174 )
2016
20
Syndrome of inappropriate secretion of antidiuretic hormone in a patient with drug-induced hypersensitivity syndrome. ( 25688750 )
2016
21
Quetiapine-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone. ( 27034875 )
2016
22
The Syndrome of Inappropriate Secretion of AntiDiuretic Hormone in Patients With Brucellosis. ( 24889373 )
2015
23
Embolization of metastatic neuroendocrine tumor resulting in clinical manifestations of syndrome of inappropriate secretion of antidiuretic hormone. ( 25805538 )
2015
24
Case of inappropriate ADH syndrome: hyponatremia due to polyethylene glycol bowel preparation. ( 25232272 )
2014
25
Combined small cell carcinoma of the sinonasal tract associated with syndrome of inappropriate secretion of antidiuretic hormone: A case report. ( 24944702 )
2014
26
Alternating syndrome of inappropriate secretion of antidiuretic hormone and cerebral salt wasting in an infant with brain tumor. ( 23171995 )
2014
27
Prompt efficacy of tolvaptan in treating hyponatremia of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) closely associated with rupture of a gastric artery aneurysm. ( 24739604 )
2014
28
Possible association of syndrome of inappropriate secretion of antidiuretic hormone with St John's wort use. ( 25203466 )
2014
29
Severe hyponatremia caused by syndrome of inappropriate secretion of antidiuretic hormone developed as initial manifestation of human herpesvirus-6-associated acute limbic encephalitis after unrelated bone marrow transplantation. ( 23173742 )
2013
30
Small cell gall bladder carcinoma complicated by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) treated with mozavaptan. ( 23761568 )
2013
31
Syndrome of inappropriate secretion of antidiuretic hormone associated with angiotensin-converting enzyme inhibitor administration. ( 22622687 )
2013
32
Syndrome of inappropriate secretion of antidiuretic hormone due to desvenlafaxine. ( 22818163 )
2013
33
Use of conivaptan for refractory syndrome of inappropriate secretion of antidiuretic hormone in a pediatric patient. ( 23546432 )
2013
34
Syndrome of inappropriate secretion of antidiuretic hormone due to selective serotonin reuptake inhibitors after pancreaticoduodenectomy for carcinoma of the ampulla of Vater: case report. ( 24229010 )
2013
35
Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases. ( 26069838 )
2013
36
A case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lupus erythematosus in the central nervous system. ( 28509213 )
2013
37
Central neurogenic diabetes insipidus, syndrome of inappropriate secretion of antidiuretic hormone, and cerebral salt-wasting syndrome in traumatic brain injury. ( 22467619 )
2012
38
A rare case of metastatic ductal type prostate adenocarcinoma presenting with syndrome of inappropriate secretion of antidiuretic hormone: a case report and review. ( 22842384 )
2012
39
Mirtazapine as an alternative for selective-serotonin-reuptake-inhibitor-induced syndrome of inappropriate secretion of antidiuretic hormone. ( 22250614 )
2012
40
Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug. ( 22323742 )
2012
41
Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with urea in critically ill patients. ( 22378162 )
2012
42
Syndrome of inappropriate secretion of antidiuretic hormone associated with localized herpes zoster ophthalmicus. ( 20878495 )
2011
43
Esophageal small-cell carcinoma with syndrome of inappropriate secretion of antidiuretic hormone. ( 21576835 )
2011
44
Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus. ( 20737184 )
2011
45
Syndrome of inappropriate secretion of antidiuretic hormone found by preoperative electrolyte analysis. ( 21257706 )
2011
46
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following carboplatin-paclitaxel administration in a patient with lung cancer. ( 22026133 )
2011
47
Syndrome of inappropriate secretion of antidiuretic hormone caused by pituitary macroadenoma with hemangiomatous stroma. ( 22167496 )
2011
48
Syndrome of inappropriate secretion of antidiuretic hormone cholestasis and pericardial effusion due to brucellosis infection: a case report. ( 20827443 )
2010
49
The syndrome of inappropriate secretion of antidiuretic hormone: diagnostic and therapeutic advances. ( 20607641 )
2010
50
Syndrome of inappropriate secretion of antidiuretic hormone and rhabdomyolysis complicating rhytidectomy. ( 20811190 )
2010
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Variations for Inappropriate Adh Syndrome

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Expression for Inappropriate Adh Syndrome

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Search GEO for disease gene expression data for Inappropriate Adh Syndrome.
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Pathways for Inappropriate Adh Syndrome

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Pathways related to Inappropriate Adh Syndrome according to KEGG:

38
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Vasopressin-regulated water reabsorption hsa04962

Pathways related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.97 AVP CNTNAP2 POMC
2
Aquaporin-mediated transport 67
Show member pathways
 11.67 AQP2 AQP4 AVP AVPR2
3
G alpha (s) signalling events 67
11.5 AVP AVPR2 POMC
4
Vasopressin-regulated water reabsorption 38
10.57 AQP2 AQP4 AVP AVPR2
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GO Terms for Inappropriate Adh Syndrome

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Cellular components related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 clathrin-coated vesicle membrane GO:0030665 8.62 AVP AVPR2

Biological processes related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.46 POMC REN
2 social behavior GO:0035176 9.43 AVP CNTNAP2
3 generation of precursor metabolites and energy GO:0006091 9.4 AVP POMC
4 excretion GO:0007588 9.37 AQP2 AVPR2
5 positive regulation of vasoconstriction GO:0045907 9.32 AVP AVPR2
6 positive regulation of systemic arterial blood pressure GO:0003084 9.26 AVP AVPR2
7 multicellular organismal water homeostasis GO:0050891 9.16 AQP4 AVP
8 water transport GO:0006833 9.13 AQP2 AQP4 AVP
9 renal water homeostasis GO:0003091 8.92 AQP2 AQP4 AVP AVPR2

Molecular functions related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.43 AVP POMC REN
2 channel activity GO:0015267 9.16 AQP2 AQP4
3 water channel activity GO:0015250 8.96 AQP2 AQP4
4 water transmembrane transporter activity GO:0005372 8.62 AQP2 AQP4
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Sources for Inappropriate Adh Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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