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SIADH
MCID: INP001
MIFTS: 49

Inappropriate Adh Syndrome (SIADH)

Categories: Cancer diseases, Endocrine diseases, Nephrological diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Inappropriate Adh Syndrome

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MalaCards integrated aliases for Inappropriate Adh Syndrome:

Name: Inappropriate Adh Syndrome 12 52 43 15 17 71
Syndrome of Inappropriate Secretion of Antidiuretic Hormone 12 36 32
Syndrome of Inappropriate Antidiuretic Hormone Secretion 12 52
Siadh 52 54
Syndrome of Inappropriate Vasopressin Secretion 12
Syndrome of Inappropriate Antidiuretic Hormone 52
Syndrome of Inappropriate Secretion of Adh 12
Schwartz Bartter Syndrome 52
Dilutional Hyponatremia 52

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases Respiratory diseases Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:3401
KEGG 36 H01682
MeSH 43 D007177
NCIt 49 C3988
SNOMED-CT 67 55004003
ICD10 32 E22.2
UMLS 71 C0021141
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Summaries for Inappropriate Adh Syndrome

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KEGG : 36 The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an endocrine disease, characterized by inappropriately concentrated urine, dilutional hyponatremia, and subsequent manifestations of various central nervous system (CNS) symptoms. Though usually transient, SIADH may be chronic. It is often associated with drug use or a lesion in the central nervous system or lung. SIADH is divided into two categories. One is the ectopic ADH syndrome induced by abnormally secreted arginine vasopressin (ADH/AVP) from cancer cells. Another is the morbidity caused by inappropriately secreted ADH from the pituitary gland. In both situations of SIADH, ADH binds to vasopressin V2 receptors (V2Rs) in renal tubules and thereby increasing water reabsorption. SIADH is difficult to distinguish from cerebral salt wasting syndrome (CSWS), another cause of hyponatremia characterized by renal loss of sodium and decreases in extracellular fluid volume during intracranial disorders. SIADH occurs in the setting of euvolemia, without evidence of renal disease or thyroxine or cortisol deficiency. Treatment options for SIADH include fluid restriction, demeclocycline, urea, frusemide and saline infusion, all of which have their limitations. The introduction of the vasopressin-2 receptor antagonists has allowed clinicians to specifically target the underlying pathophysiology of SIADH.

MalaCards based summary : Inappropriate Adh Syndrome, also known as syndrome of inappropriate secretion of antidiuretic hormone, is related to nephrogenic syndrome of inappropriate antidiuresis and pure autonomic failure, and has symptoms including polyuria An important gene associated with Inappropriate Adh Syndrome is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Vasopressin-regulated water reabsorption. The drugs Tolvaptan and Arginine Vasopressin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and lung, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 52 Syndrome of inappropriate antidiuretic hormone (SIADH) occurs when an excessive amount of antidiuretic hormone is released resulting in water retention and a low sodium level. It is most common among older people. It has many causes including, but not limited too, pain, stress, exercise, a low blood sugar level, certain disorders of the heart, thyroid gland, kidneys, or adrenal glands, and the use of certain medications. Disorders of the lungs and certain cancers may increase the risk of developing SIADH. Treatment includes fluid restriction and sometimes the use of medications that decrease the effect of antidiuretic hormone on the kidneys.

Wikipedia : 74 Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive... more...

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Related Diseases for Inappropriate Adh Syndrome

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Diseases related to Inappropriate Adh Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 578)
# Related Disease Score Top Affiliating Genes
1 nephrogenic syndrome of inappropriate antidiuresis 33.1 AVPR2 AVP
2 pure autonomic failure 30.9 REN NPPA
3 lung oat cell carcinoma 30.8 POMC AVP
4 pituitary apoplexy 30.7 POMC AVP
5 malignant hypertension 30.4 REN NPPB NPPA
6 paralytic ileus 30.4 AVP ALB
7 bartter disease 30.4 REN AVP AQP2
8 sleep apnea 30.3 REN NPPB ALB
9 hydrops, lactic acidosis, and sideroblastic anemia 30.1 AQP4 ALB
10 myocarditis 30.0 NPPB NPPA ALB
11 hypokalemia 29.9 REN POMC AVPR2 AQP2 ALB
12 acute kidney failure 29.9 REN NPPA ALB
13 eclampsia 29.8 REN OXT ALB
14 nephrolithiasis, calcium oxalate 29.8 REN AVP AQP2 ALB
15 obstructive hydrocephalus 29.8 AQP4 AQP1
16 congestive heart failure 29.8 REN NPPB NPPA AQP2 ALB
17 pericardial effusion 29.7 REN NPPB NPPA ALB
18 respiratory failure 29.7 REN NPPB NPPA ALB
19 diabetes insipidus 29.5 REN POMC OXT AVPR2 AVP AQP3
20 liver cirrhosis 29.5 REN NPPA AVP AQP2 ALB
21 hydronephrosis 29.5 REN AQP2 ALB
22 central pontine myelinolysis 29.4 AVPR2 AVP AQP4 AQP2 AQP1
23 peripheral nervous system disease 29.4 POMC AQP4 ALB
24 brain edema 29.4 AQP4 AQP1 ALB
25 pre-eclampsia 29.4 REN OXT NPPA ALB
26 intracranial hypertension 29.2 NPPB AQP4 AQP1 ALB
27 pulmonary hypertension 29.1 REN NPPB NPPA ALB
28 meniere disease 29.0 AQP4 AQP3 AQP2 AQP1
29 stroke, ischemic 28.9 REN NPPB NPPA AVP AQP4 ALB
30 cardiac arrest 28.8 REN OXT NPPB AVP ALB
31 chronic kidney disease 28.8 REN POMC NPPB NPPA AVP AQP2
32 hepatorenal syndrome 28.6 REN NPPA AVP AQP2 AQP1 ALB
33 polycystic kidney disease 28.5 REN AVPR2 AVP AQP2 AQP1 ALB
34 hypertension, essential 28.4 REN POMC OXT NPPB NPPA AVP
35 autosomal dominant polycystic kidney disease 27.9 REN AVPR2 AVP AQP3 AQP2 AQP1
36 diabetes insipidus, nephrogenic, autosomal 27.8 REN OXT AVPR2 AVP AQP4 AQP3
37 small cell carcinoma 10.6
38 neuroendocrine carcinoma 10.5
39 ocular motor apraxia 10.5
40 olfactory neuroblastoma 10.5
41 neuroblastoma 10.5
42 herpes zoster 10.5
43 systemic lupus erythematosus 10.5
44 lupus erythematosus 10.5
45 small cell cancer of the lung 10.5
46 lung disease 10.5
47 antisynthetase syndrome 10.5
48 paraneoplastic syndromes 10.5
49 acth-dependent cushing syndrome 10.5 POMC AVPR2
50 pituitary infarct 10.4 POMC AVP

Graphical network of the top 20 diseases related to Inappropriate Adh Syndrome:



Diseases related to Inappropriate Adh Syndrome
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Symptoms & Phenotypes for Inappropriate Adh Syndrome

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UMLS symptoms related to Inappropriate Adh Syndrome:


polyuria

MGI Mouse Phenotypes related to Inappropriate Adh Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 AQP1 AQP2 AQP3 AQP4 AVP AVPR2
2 growth/size/body region MP:0005378 10.02 AQP1 AQP2 AQP3 AQP4 AVPR2 CPOX
3 cardiovascular system MP:0005385 9.97 ALB AQP1 AQP3 AQP4 NPPA OXT
4 homeostasis/metabolism MP:0005376 9.93 ALB AQP1 AQP2 AQP3 AQP4 AVP
5 hematopoietic system MP:0005397 9.91 AQP1 AQP2 AQP4 AVP AVPR2 CPOX
6 mortality/aging MP:0010768 9.73 ALB AQP1 AQP2 AQP3 AQP4 AVP
7 renal/urinary system MP:0005367 9.36 ALB AQP1 AQP2 AQP3 AQP4 AVP
Sources

Drugs & Therapeutics for Inappropriate Adh Syndrome

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Drugs for Inappropriate Adh Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tolvaptan Approved Phase 4 150683-30-0 216237
2 Arginine Vasopressin Phase 4
3 Natriuretic Agents Phase 4
4 Hormones Phase 4
5 Vasopressins Phase 4
6 Liver Extracts Phase 4
7
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10
leucovorin Approved Phase 3 58-05-9 6006 143
11
Mercaptopurine Approved Phase 3 50-44-2 667490
12
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
13
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
14
Lenograstim Approved, Investigational Phase 3 135968-09-1
15
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
16
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
17
Pegaspargase Approved, Investigational Phase 3 130167-69-0
18
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
19
Etoposide Approved Phase 3 33419-42-0 36462
20
Empagliflozin Approved Phase 2, Phase 3 864070-44-0
21
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
22
Aspartic acid Approved, Nutraceutical Phase 3 56-84-8 5960
23
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
24
Satavaptan Investigational Phase 3 185913-78-4 7029
25 Hormone Antagonists Phase 3
26 Hemostatics Phase 3
27 Vasoconstrictor Agents Phase 3
28 Coagulants Phase 3
29 Deamino Arginine Vasopressin Phase 2, Phase 3
30 Antiemetics Phase 3
31 Gastrointestinal Agents Phase 3
32
asparaginase Phase 3
33 Anti-Bacterial Agents Phase 3
34 Vitamin B Complex Phase 3
35 Folic Acid Antagonists Phase 3
36 Anti-Infective Agents Phase 3
37 Antibiotics, Antitubercular Phase 3
38 Topoisomerase Inhibitors Phase 3
39 N-Methylaspartate Phase 3
40 BB 1101 Phase 3
41 Dermatologic Agents Phase 3
42 Vitamin B9 Phase 3
43 Autonomic Agents Phase 3
44 Anti-Inflammatory Agents Phase 3
45 Antiviral Agents Phase 3
46 Folate Phase 3
47 Calcium, Dietary Phase 3
48
Liposomal doxorubicin Phase 3 31703
49 Antineoplastic Agents, Hormonal Phase 3
50 Antimetabolites Phase 3

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Tolvaptan for Liver Cirrhotic Patients With Hyponatremia and Ascites: A Multi-center, Randomized, Double-blind, Placebo-controlled 4-weeks Clinical Trial Unknown status NCT01716611 Phase 4 Tolvaptan;placebo
2 Evaluation of the Effects of Monopolar Transurethral Resection Versus Bipolar Transurethral Resection and Holmium Laser Enucleation of the Prostate on Urinary and Sexual Function; a Prospective Comparative Study. Completed NCT01810068 Phase 4
3 Assessment of Clinical Outcome and Treatment Quality Under Adequate Use of Tolvaptan In Correction of Hyponatremia in Patients Hospitalized With Worsening Heart Failure and Hyponatremia Terminated NCT02352285 Phase 4 Tolvaptan;Placebo
4 Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia Terminated NCT01890694 Phase 4 Tolvaptan;Placebo
5 Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-secretion Caused by Treatment With Antiepileptic Medicine Withdrawn NCT00298753 Phase 4
6 A Multicenter, Randomized, Double-blind, Placebo-controlled (Standard Therapy + Placebo) Study to Evaluate the Efficacy and Safety of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia Unknown status NCT01507727 Phase 2, Phase 3 Tolvaptan;Placebo
7 A Randomized, Double-Blind, Placebo-Group, Multicenter Study Evaluating the Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264927 Phase 3 SR121463B
8 An Open-Label, Multicenter Study Evaluating the Long-Term Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264914 Phase 3 SR121463B
9 A Multicenter, Uncontrolled, Open-label, Dose-titration Trial to Investigate the Efficacy and Safety of Tolvaptan Tablets in Patients With Hyponatremia in Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Completed NCT03048747 Phase 3 Tolvaptan Oral Tablet
10 Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study Completed NCT02729766 Phase 2, Phase 3 Empagliflozin 25mg Tbl;Placebo P-Tablet
11 Intensive Treatment for Intermediate-Risk Relapse of Childhood B-precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies Completed NCT00381680 Phase 3 vincristine sulfate;prednisone;doxorubicin hydrochloride;pegaspargase;cytarabine;methotrexate;dexamethasone;etoposide;cyclophosphamide;leucovorin calcium;asparaginase;mercaptopurine
12 A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial Evaluating the Effect of a Vasopressin V2 Receptor Antagonist (SR121463B) on Serum Sodium in Patients With Dilutional Hyponatremia Completed NCT00274326 Phase 3 SR121463B
13 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia Completed NCT00660959 Phase 3 lixivaptan;placebo
14 Effects of the SGLT2-inhibitor Empagliflozin on Patients With SIADH - the SAND Study Completed NCT02874807 Phase 2, Phase 3 Empagliflozin
15 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia Completed NCT00072683 Phase 3 tolvaptan
16 Multicenter, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia, Study 2 Completed NCT00201994 Phase 3 Tolvaptan
17 A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia Completed NCT00876798 Phase 3 Lixivaptan;Placebo
18 Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study Recruiting NCT03202667 Phase 2, Phase 3 Empagliflozin 25mg;Placebo
19 A Double-Blind, Randomized, Placebo-Controlled Multicenter Study Evaluating the Efficacy and Safety of Two Doses of Satavaptan (SR121463B) Versus Placebo in Patients With Dilutional Hyponatremia Due to the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Terminated NCT00728091 Phase 3 Satavaptan;placebo
20 Phase 3b, Multicenter, Randomized, Single-blind, Parallel Group Trial of the Effects of Titrated Oral SAMSCA(r) (Tolvaptan) 15, 30, or 60 mg QD Compared to Placebo Plus Fluid Restriction on Length of Hospital Stay and Symptoms in Subjects Hospitalized With Dilutional Hyponatremia Terminated NCT01227512 Phase 3 tolvaptan
21 A Phase 3b, Multicenter, Open-label, Randomized Withdrawal Trial of the Effects of Titrated Oral SAMSCA ® (Tolvaptan) on Serum Sodium, Pharmacokinetics, and Safety in Children and Adolescent Subjects Hospitalized With Euvolemic or Hypervolemic Hyponatremia Terminated NCT02012959 Phase 3 Tolvaptan
22 A Phase 3b, Multicenter, Extension Follow-up Trial to Evaluate the Long-term Safety of Children and Adolescent Subjects With Euvolemic or Hypervolemic Hyponatremia Who Have Previously Participated in a Trial of Titrated Oral SAMSCA® (Tolvaptan) Terminated NCT02020278 Phase 3 Tolvaptan
23 A Pilot Phase 3b,Multicenter,Randomized,Double-blind,Placebo-controlled Trial of the Safety,Efficacy,and Pharmacokinetics of Titrated Oral SAMSCA®(Tolvaptan) in Children and Adolescent Subjects With Euvolemic or Hypervolemic Hyponatremia Withdrawn NCT02442674 Phase 3 Tolvaptan
24 Hematological, Biochemical and Hemodynamic Changes During Operative Hysteroscopy Using Consecutive Distension Media Unknown status NCT03166228 Phase 2 Normal Saline 0.9% Infusion Solution Bag;1.5% Glycine only
25 A Phase 1b, Multicenter, Pilot, Randomized, Double-blind Trial to Determine the Pharmacokinetics and Pharmacodynamics of Orally Administered Tolvaptan 3.75, 7.5, and 15 mg Tablets in Subjects With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT02009878 Phase 1, Phase 2 tolvaptan
26 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Escalation, Multicenter Study Evaluating the Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion. Completed NCT00032734 Phase 2 satavaptan (SR121463B)
27 Randomized, Double-blind, Multicenter, Placebo-controlled (Standard Therapy + Placebo), Phase 2 Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia Completed NCT00664014 Phase 2 Tolvaptan;Placebo
28 Non-myeloablative Autologous Hematopoietic Stem Cell Transplantation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy: A Phase II Trial Active, not recruiting NCT00278629 Phase 2
29 A Pilot Study To Evaluate The Incidence Of Hyponatremia In A Medical-Surgical Hospital And To Explore The Efficacy And Safety Of Tolvaptan In The Clinical Practice Terminated NCT01386372 Phase 2 Tolvaptan
30 Transplantation of Expanded and Unexpanded Umbilical Cord Blood Units Following Myeloablative Chemotherapy for Hematologic Malignancies Terminated NCT00539656 Phase 1, Phase 2
31 Hematopoietic Stem Cell Transplant in Patients With Refractory Sarcoidosis: A Phase I/II Trial Terminated NCT00282438 Phase 1, Phase 2
32 High Dose Immune Suppression With Hematopoietic Stem Cell Support in Refractory Vasculitis, Necrotizing Vasculitis, Neurovascular Behcet's Disease, and Sjogren's Syndrome Terminated NCT00278512 Phase 1 Cyclophosphamide;ATG (rabbit);G-CSF;Campath-1h;Fludarabine;Tacrolimus;Mesna
33 A Multi-Centre, Multi-National, Observational Post-Authorisation Safety Study to Document the Drug Utilisation of Samsca and to Collect Information on the Safety of Samsca When Used in Routine Medical Practice Unknown status NCT01228682 Tolvaptan
34 Comparison of Ringer Lactate and Isotonic Acetate Solution as Maintenance Fluids in Children Undergoing Elective Laparoscopic Surgery Unknown status NCT02936167
35 A Non Interventional, Retrospective Study on Real World Usage and Treatment Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to the SIADH. Completed NCT02545101
36 An Observational Prospective Registry to Identify Demographic and Clinical Characteristics of Patients Hospitalized With Euvolemic and Hypervolemic Hyponatremia and Assess the Comparative Effectiveness of Available Treatments and the Impact on Resource Utilization Completed NCT01240668
37 An Observational, Retrospective Study to Describe the Extent of Adherence to the Spanish Society of Medical Oncology Algorithm for the Treatment of Hyponatraemia Secondary to SIADH in Oncology Patients in Spain (ALGA) Completed NCT02548845
38 Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors Completed NCT03570203
39 Comparison of the Vasopressin-2 Antagonist Tolvaptan and Fluid Restriction in the Treatment of Hyponatremia Following Pituitary Surgery Completed NCT04119206
40 A Prospective, Observational Study Measuring Sodium Improvement and Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia Secondary to SIADH in Italy Completed NCT02573077
41 Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH? Completed NCT01341665
42 International, Multicenter Study of a Twenty-eight Week, Open-label, Titrated Oral Lixivaptan Administration in Patients With Chronic Hyponatremia: Extension to Studies CK-LX3401, 3405, and 3430 Completed NCT01056848
43 Copeptin as a Diagnostic Marker in the Management of Neurosurgical Patients With Disturbance of Water Homeostasis Completed NCT01465672
44 Phenotypic Characterization of Neuropsychologic and Physical Performance in Geriatric Patients Suffering From Hyponatremia. Completed NCT02242604
45 Disturbances of the Sodium and Fluid Balance in Patients With Severe Traumatic Brain Injury and Non-traumatic Subarachnoid Hemorrhage. A Systematic Observational Study Completed NCT01313975
46 Copeptin as a Novel Diagnostic and Prognostic Marker in the Management of Neurological and Neurosurgical Patients With Sodium Imbalance The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment) Completed NCT00390962
47 Laser Prostatectomy for Benign Prostatic Hyperplasia: A Registry and Database Recruiting NCT00159406
48 Prophylaxis Versus Treatment Against TURP Syndrome : Role of Hypertonic Saline Active, not recruiting NCT03428451 NaCl 3% HS;NaCl 3% HS;NaCl 0.9% NS
49 Standardization of Fluids in Inpatient Settings Active, not recruiting NCT03924674
50 Transthoracic Echocardiographic Evaluation of the Cardiac Function During Transurethral Resection of Prostate in Elderly Patients Terminated NCT02288780

Search NIH Clinical Center for Inappropriate Adh Syndrome

Cochrane evidence based reviews: inappropriate adh syndrome

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Genetic Tests for Inappropriate Adh Syndrome

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Anatomical Context for Inappropriate Adh Syndrome

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MalaCards organs/tissues related to Inappropriate Adh Syndrome:

40
Pituitary, Kidney, Lung, Heart, Prostate, Brain, Thyroid
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Publications for Inappropriate Adh Syndrome

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Articles related to Inappropriate Adh Syndrome:

(show top 50) (show all 753)
# Title Authors PMID Year
1
Hyponatremia and brain injury: absence of alterations of serum brain natriuretic peptide and vasopressin. 54 61
20069215 2009
2
[Hyponatraemia in patients with neurosurgical disorders: SIADH or cerebral salt wasting syndrome?]. 54 61
19885796 2009
3
Intermittent severe, symptomatic hyponatraemia due to the nephrogenic syndrome of inappropriate antidiuresis. 54 61
18753429 2008
4
Hypothalamic-pituitary-adrenal axis and interleukin-6 activity in children with head trauma and syndrome of inappropriate secretion of antidiuretic hormone. 54 61
12585340 2003
5
Close association of urinary excretion of aquaporin-2 with appropriate and inappropriate arginine vasopressin-dependent antidiuresis in hyponatremia in elderly subjects. 54 61
11297601 2001
6
[Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. 54 61
10614173 1999
7
Acute aquaresis by the nonpeptide arginine vasopressin (AVP) antagonist OPC-31260 improves hyponatremia in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). 54 61
9100572 1997
8
A case of syndrome of inappropriate secretion of antidiuretic hormone associated with diabetes mellitus. 54 61
1794339 1991
9
Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association? 61
31823899 2020
10
Evolution and evolving resolution of controversy over existence and prevalence of cerebral/renal salt wasting. 61
31904619 2020
11
Long-term Survival of a Patient with Small Cell Lung Cancer Secreting ADH and ACTH Simultaneously, Following the Prolonged Use of Amrubicin. 61
31511478 2020
12
Neurofibromatosis type 1-associated malignant peripheral nerve sheath tumour carcinomatous pleurisy: an autopsy case. 61
31346470 2019
13
Nonosmotic secretion of arginine vasopressin and salt loss in hyponatremia in Kawasaki disease. 61
31657491 2019
14
Severe Hyponatremia Due to Cisplatin-induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone. 61
31641557 2019
15
A Study of Hyponatremia in Acute Encephalitis Syndrome: A Prospective Study From a Tertiary Care Center in India. 61
28393593 2019
16
Tolvaptan corrects hyponatremia and relieves the burden of fluid/dietary restriction and hospitalization in hyponatremic patients with terminal lung cancer: a report of two cases. 61
30637666 2019
17
A rare iatrogenic association of syndrome of inappropriate secretion of antidiuretic hormone, neuroleptic malignant syndrome and rhabdomyolysis. 61
30949348 2019
18
SIADH versus adrenal insufficiency: a life-threatening misdiagnosis. 61
30728045 2019
19
Pituitary macroadenoma presenting as severe hyponatremia: a case report. 61
30795800 2019
20
A case of drug-induced hypersensitivity syndrome induced by salazosulfapyridine combined with SIADH caused by interstitial pneumonia. 61
31534076 2019
21
Syndrome of inappropriate secretion of antidiuretic hormone associated with angiotensin-converting enzyme inhibitor therapy in the perioperative period. 61
30843458 2019
22
A case report of a thymic neuroblastoma associated with syndrome of inappropriate secretion of antidiuretic hormone: Ten-year follow-up results after surgical treatment. 61
31005046 2019
23
Hyponatremia in patients with esophageal cancer treated with chemotherapy including cisplatin. 61
30225740 2018
24
Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan. 61
29478867 2018
25
Tolvaptan for the Syndrome of Inappropriate Secretion of Antidiuretic Hormone: Is the Dose Too High? 61
29801549 2018
26
A study of atrial and brain natriuretic peptides in tuberculous meningitis and acute encephalitis. 61
29562995 2018
27
Safety and Efficacy of Tolvaptan in Korean Patients with Hyponatremia Caused by the Syndrome of Inappropriate Antidiuretic Hormone. 61
29629516 2018
28
Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Hyponatremia. 61
29292284 2018
29
Determining Fractional Urate Excretion Rates in Hyponatremic Conditions and Improved Methods to Distinguish Cerebral/Renal Salt Wasting From the Syndrome of Inappropriate Secretion of Antidiuretic Hormone. 61
30560127 2018
30
Severe Solute Depletion in Patients with Hyponatremia Due to Diuretics Despite Biochemical Pictures Similar Than Those Observed in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone. 61
29990986 2018
31
[SMALL CELL PROSTATE CANCER PRODUCING SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE; A CASE REPORT]. 61
31631089 2018
32
[Syndrome of inappropriate secretion of antidiuretic hormone in multiple myeloma patients treated with bortezomib, lenalidomide, and dexamethasone combination therapy]. 61
30531137 2018
33
Presenting Symptoms of Pituitary Apoplexy. 61
28437813 2018
34
SIADH in Systemic JIA Resolving After Treatment With an IL-6 Inhibitor. 61
29242269 2018
35
A Case of Neurosarcoidosis-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone Diagnosed with Neuroendoscopy. 61
30158982 2018
36
[A CASE OF SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS ACCOMPANIED BY THE SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE]. 61
29459527 2018
37
Managing hyponatremia in lung cancer: latest evidence and clinical implications. 61
29344107 2017
38
Localized herpes zoster infection: a rare cause of syndrome of inappropriate secretion of antidiuretic hormone. 61
29230301 2017
39
Cerebral Salt-Wasting Syndrome: Diagnosis by Urine Sodium Excretion. 61
29078838 2017
40
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) due to bortezomib in a case of light chain multiple mieloma. Treatment with tolvaptan. 61
28946972 2017
41
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Preceding Guillain-Barré Syndrome. 61
29207765 2017
42
Electrolytes: Sodium Disorders. 61
28806046 2017
43
Dysnatremia as a poor prognostic indicator in patients with acute subarachnoid hemorrhage. 61
26496416 2017
44
Successful Radiotherapy for Advanced Small Cell Carcinoma of the Prostate with Syndrome of Inappropriate Secretion of Antidiuretic Hormone. 61
28567332 2017
45
[Atypical Guillain-Barre syndrome clustering: is it necessary to reconsider the diagnostic criteria and microbiological protocol?] 61
28444683 2017
46
Cerebral Salt Wasting Is the Most Common Cause of Hyponatremia in Stroke. 61
28110888 2017
47
Severe hyponatremia in a patient with schizophrenia associated with prolonged consciousness disturbance. 61
28509122 2017
48
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient. 61
28271051 2017
49
Influenza as a Cause of SIADH Related Hyponatremia: A Case Report. 61
28658832 2017
50
Refractory Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Systemic Lupus Erythematosus-associated Hypophysitis. 61
28604351 2017
Sources

Variations for Inappropriate Adh Syndrome

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Cosmic variations for Inappropriate Adh Syndrome:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM89368095 adrenal gland,adrenal gland,adrenal cortical adenoma,cortisol producing c.133T>C p.S45P 3:41224645-41224645 4
Sources

Expression for Inappropriate Adh Syndrome

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Search GEO for disease gene expression data for Inappropriate Adh Syndrome.
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Pathways for Inappropriate Adh Syndrome

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Pathways related to Inappropriate Adh Syndrome according to KEGG:

36
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Vasopressin-regulated water reabsorption hsa04962

Pathways related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 65
Show member pathways
 12.83 AVPR2 AVP AQP4 AQP3 AQP2 AQP1
2
Oxytocin signaling pathway 36
Show member pathways
 12.08 OXT NPPB NPPA AVP
3
Aquaporin-mediated transport 65
Show member pathways
 11.85 AVPR2 AVP AQP4 AQP3 AQP2 AQP1
4
G alpha (s) signalling events 65
11.71 POMC AVPR2 AVP
5
Renin secretion 36
11.27 REN NPPA AQP1
6
Cardiomyocyte Differentiation through BMP Receptors 63
10.75 NPPB NPPA
7
Vasopressin-regulated water reabsorption 36
10.66 AVPR2 AVP AQP4 AQP3 AQP2
Sources

GO Terms for Inappropriate Adh Syndrome

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Cellular components related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 REN POMC OXT NPPB NPPA LGI1
2 basolateral plasma membrane GO:0016323 9.46 AQP4 AQP3 AQP2 AQP1
3 secretory granule GO:0030141 9.43 POMC OXT AVP
4 extracellular region GO:0005576 9.28 REN POMC OXT NPPB NPPA LGI1

Biological processes related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.75 POMC NPPB NPPA
2 regulation of blood pressure GO:0008217 9.62 REN POMC NPPB NPPA
3 cellular response to copper ion GO:0071280 9.61 AQP2 AQP1
4 positive regulation of blood pressure GO:0045777 9.61 OXT AVPR2
5 positive regulation of synaptic transmission GO:0050806 9.6 OXT LGI1
6 positive regulation of renal sodium excretion GO:0035815 9.59 OXT NPPB
7 grooming behavior GO:0007625 9.58 OXT AVP
8 negative regulation of systemic arterial blood pressure GO:0003085 9.57 NPPB NPPA
9 maternal behavior GO:0042711 9.56 OXT AVP
10 cGMP biosynthetic process GO:0006182 9.55 NPPB NPPA
11 receptor guanylyl cyclase signaling pathway GO:0007168 9.54 NPPB NPPA
12 cGMP-mediated signaling GO:0019934 9.54 NPPB NPPA AQP1
13 positive regulation of systemic arterial blood pressure GO:0003084 9.52 AVPR2 AVP
14 drinking behavior GO:0042756 9.51 REN OXT
15 hyperosmotic salinity response GO:0042538 9.49 OXT AVP
16 negative regulation of urine volume GO:0035811 9.48 OXT AVPR2
17 maternal aggressive behavior GO:0002125 9.46 OXT AVP
18 cellular response to mercury ion GO:0071288 9.43 AQP2 AQP1
19 multicellular organismal water homeostasis GO:0050891 9.43 AVP AQP4 AQP1
20 renal water transport GO:0003097 9.4 AQP2 AQP1
21 water transport GO:0006833 9.35 AVP AQP4 AQP3 AQP2 AQP1
22 glycerol transport GO:0015793 9.33 AQP3 AQP2 AQP1
23 renal water homeostasis GO:0003091 9.1 AVPR2 AVP AQP4 AQP3 AQP2 AQP1

Molecular functions related to Inappropriate Adh Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.73 REN POMC NPPB NPPA LGI1 AVP
2 hormone activity GO:0005179 9.55 POMC OXT NPPB NPPA AVP
3 neuropeptide hormone activity GO:0005184 9.5 OXT NPPA AVP
4 hormone receptor binding GO:0051427 9.46 NPPB NPPA
5 water transmembrane transporter activity GO:0005372 9.43 AQP2 AQP1
6 glycerol transmembrane transporter activity GO:0015168 9.4 AQP2 AQP1
7 neurohypophyseal hormone activity GO:0005185 9.37 OXT AVP
8 channel activity GO:0015267 9.26 AQP4 AQP3 AQP2 AQP1
9 water channel activity GO:0015250 8.92 AQP4 AQP3 AQP2 AQP1
Sources

Sources for Inappropriate Adh Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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