MSP2
MCID: INC033
MIFTS: 26

Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 (MSP2)

Categories: Bone diseases, Genetic diseases, Mental diseases

Aliases & Classifications for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

MalaCards integrated aliases for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2:

Name: Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 12 15
Multisystem Proteinopathy 2 12
Ibmpfd2 12
Msp2 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0111384

Summaries for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Disease Ontology : 12 An inclusion body myopathy with Paget disease of bone and frontotemporal dementia that has material basis in heterozygous mutation in HNRPA2B1 on 7p15.2.

MalaCards based summary : Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2, also known as multisystem proteinopathy 2, is related to ehrlichiosis and malaria. An important gene associated with Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 is AKR1C2 (Aldo-Keto Reductase Family 1 Member C2). Affiliated tissues include bone, placenta and myeloid.

Related Diseases for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Diseases in the Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 family:

Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 1

Diseases related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 ehrlichiosis 29.7 HSPD1 EDC4 CENPV CD4
2 malaria 28.9 NSL1 MT-CYB HSPD1 GYPA DHPS DHFR
3 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 3 28.9 XPO1 SARS2 SARS1 RHAG GYPA DNAAF2
4 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 11.2
5 human granulocytic anaplasmosis 10.4
6 keipert syndrome 10.3 XPO1 H2AC18
7 lynch syndrome i 10.2 SARS2 SARS1 AKR1C2
8 colorectal cancer, hereditary nonpolyposis, type 2 10.2 DNAAF2 AKR1C2
9 endemic typhus 10.2 HSPD1 H2AC18 CS
10 autoimmune atherosclerosis 10.1 HSPD1 CD4
11 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 3 10.1
12 plasmodium falciparum malaria 10.1
13 rocky mountain spotted fever 10.1 HSPD1 CS
14 opportunistic bacterial infectious disease 10.1 HSPD1 CD4
15 hyperinsulinemic hypoglycemia, familial, 3 10.1 H2AC18 EDC4
16 nocardiosis 10.1 HSPD1 CD4
17 chancroid 10.1 HSPD1 CD4
18 glanders 10.1 HSPD1 CD4
19 carrion's disease 10.1 HSPD1 GYPA CS
20 tenosynovitis 10.1 HSPD1 CD4
21 cystoisosporiasis 10.1 DHPS CD4
22 cervical adenitis 10.1 HSPD1 CD4
23 commensal bacterial infectious disease 10.0 HSPD1 H2AC18 CD4
24 disease by infectious agent 10.0
25 mixed malaria 10.0 MT-CYB AKR1C2
26 testicular disease 10.0 HSPD1 H2AC18 CD4
27 plasmodium malariae malaria 10.0 MT-CYB DHFR
28 trench fever 10.0 MT-CYB HSPD1
29 primary bacterial infectious disease 10.0 HSPD1 H2AC18 CD4
30 neuroretinitis 10.0 CS CD4
31 spinal cord disease 10.0 H2AC18 CENPV CD4
32 whipple disease 10.0 HSPD1 DHPS CD4
33 basidiobolomycosis 10.0 MT-CYB HSPD1
34 hypotrichosis 2 10.0 H2AC18 DHPS CD4
35 adiaspiromycosis 10.0 HSPD1 CD4
36 cat-scratch disease 9.9 HSPD1 CS CD4
37 haverhill fever 9.9 MT-CYB HSPD1
38 salpingitis 9.9 HSPD1 CD4
39 ocular motor apraxia 9.9
40 severe combined immunodeficiency 9.9
41 thalassemia 9.9
42 pediculus humanus corporis infestation 9.9 MT-CYB CS
43 cyclosporiasis 9.8 MT-CYB CD4
44 immune deficiency disease 9.8 XPO1 HSPD1 H2AC18 DHFR CD4
45 chlamydia pneumonia 9.8 HSPD1 CD4
46 mucocutaneous leishmaniasis 9.7 MT-CYB H2AC18 CD4
47 parasitic ectoparasitic infectious disease 9.7 MT-CYB H2AC18 CD4
48 splenic disease 9.7 MT-CYB H2AC18 CD4
49 ophthalmomyiasis 9.7 MT-CYB CD4
50 babesiosis 9.7 MT-CYB CD4 CCT7

Graphical network of the top 20 diseases related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2:



Diseases related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2

Symptoms & Phenotypes for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Drugs & Therapeutics for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Search Clinical Trials , NIH Clinical Center for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2

Genetic Tests for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Anatomical Context for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

MalaCards organs/tissues related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2:

40
Bone, Placenta, Myeloid, Salivary Gland, T Cells, Endothelial

Publications for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Articles related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2:

(show top 50) (show all 492)
# Title Authors PMID Year
1
Molecular detection and identification of piroplasms (Babesia spp. and Theileria spp.) and Anaplasma phagocytophilum in questing ticks from northwest Spain. 61
32757238 2021
2
Genetic polymorphisms of Plasmodium falciparum isolates from Melka-Werer, North East Ethiopia based on the merozoite surface protein-2 (msp-2) gene as a molecular marker. 61
33579293 2021
3
Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density. 61
33413393 2021
4
Merozoite surface protein 2 adsorbed onto acetalated dextran microparticles for malaria vaccination. 61
33309558 2021
5
Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations. 61
33436004 2021
6
Molecular surveillance and temporal monitoring of malaria parasites in focal Vietnamese provinces. 61
33384023 2020
7
Evaluation of Histidine-Rich Proteins 2 and 3 Gene Deletions in Plasmodium falciparum in Endemic Areas of the Brazilian Amazon. 61
33375379 2020
8
Anaplasma phagocytophilum and Other Anaplasma spp. in Various Hosts in the Mnisi Community, Mpumalanga Province, South Africa. 61
33217891 2020
9
Prevalence of Asymptomatic Malaria Parasitemia in Odisha, India: A Challenge to Malaria Elimination. 61
32783792 2020
10
The role of different species of wild ungulates and Ixodes ricinus ticks in the circulation of genetic variants of Anaplasma phagocytophilum in a forest biotope in north-western Poland. 61
32723651 2020
11
Genetic diversity of Plasmodium falciparum in Grande Comore Island. 61
32883282 2020
12
Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso. 61
32819420 2020
13
Molecular surveillance reveals the presence of pfhrp2 and pfhrp3 gene deletions in Plasmodium falciparum parasite populations in Uganda, 2017-2019. 61
32843041 2020
14
Optimization and Evaluation of a Multiplex Quantitative PCR Assay for Detection of Nucleic Acids in Human Blood Samples from Patients with Spotted Fever Rickettsiosis, Typhus Rickettsiosis, Scrub Typhus, Monocytic Ehrlichiosis, and Granulocytic Anaplasmosis. 61
32493778 2020
15
Serological and molecular detection of Anaplasma phagocytophilum in Thoroughbred horses from Chilean racecourses. 61
32305236 2020
16
An outbreak of bovine babesiosis in February, 2019, triggered by above average winter temperatures in southern England and co-infection with Babesia divergens and Anaplasma phagocytophilum. 61
32532309 2020
17
Efficacy and safety of artemisinin-based combination therapy and the implications of Pfkelch13 and Pfcoronin molecular markers in treatment failure in Senegal. 61
32483161 2020
18
Measuring antibody avidity to Plasmodium falciparum merozoite antigens using a multiplex immunoassay approach. 61
32357882 2020
19
Molecular detection and genetic diversity of Anaplasma marginale based on the major surface protein genes in Thailand. 61
31953063 2020
20
Prolonged Heat Stress of Lactobacillus paracasei GCRL163 Improves Binding to Human Colorectal Adenocarcinoma HT-29 Cells and Modulates the Relative Abundance of Secreted and Cell Surface-Located Proteins. 61
32108472 2020
21
Development of a Sensitive and Rapid Recombinase Polymerase Amplification Assay for Detection of Anaplasma phagocytophilum. 61
32132189 2020
22
Transovarial transmission of Borrelia spp., Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus under field conditions extrapolated from DNA detection in questing larvae. 61
32264920 2020
23
Prevalence and molecular characterization of Anaplasma phagocytophilum in roe deer (Capreolus capreolus) from Spain. 61
31822398 2020
24
Molecular detection and phylogenetic analysis of canine tick-borne pathogens from Korea. 61
31839473 2020
25
Variation of prevalence of malaria, parasite density and the multiplicity of Plasmodium falciparum infection throughout the year at three different health centers in Brazzaville, Republic of Congo. 61
32131754 2020
26
Genetic diversity of Plasmodium falciparum and genetic profile in children affected by uncomplicated malaria in Cameroon. 61
32188442 2020
27
Impact of an Irrigation Dam on the Transmission and Diversity of Plasmodium falciparum in a Seasonal Malaria Transmission Area of Northern Ghana. 61
32308690 2020
28
The immunoglobulin G antibody response to malaria merozoite antigens in asymptomatic children co-infected with malaria and intestinal parasites. 61
33170876 2020
29
Study of the cwaRS-ldcA Operon Coding a Two-Component System and a Putative L,D-Carboxypeptidase in Lactobacillus paracasei. 61
32194510 2020
30
Monitoring of efficacy, tolerability and safety of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial. 61
31842893 2019
31
Development of nematode resistance in Arabidopsis by HD-RNAi-mediated silencing of the effector gene Mi-msp2. 61
31757987 2019
32
Genetic polymorphism of merozoite surface proteins 1 and 2 of Plasmodium falciparum in the China-Myanmar border region. 61
31744492 2019
33
Presence of Roe Deer Affects the Occurrence of Anaplasma phagocytophilum Ecotypes in Questing Ixodes ricinus in Different Habitat Types of Central Europe. 61
31783486 2019
34
Insight of diagnostic performance using B-cell epitope antigens derived from triple P44-related proteins of Anaplasma phagocytophilum. 61
31182246 2019
35
Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal. 61
32127816 2019
36
Human granulocytic anaplasmosis in Kinmen, an offshore island of Taiwan. 61
31539395 2019
37
Characterization of Glycoproteins of Native 19kDa C-Terminal Merozoite Surface Protein-1 from Native Antigen of Plasmodium falciparum. 61
31879671 2019
38
Immunogenicity of a recombinant fusion construct composed of intrinsically unstructured, low polymorphic segments derived from merozoite surface protein 2 and trophozoite exported protein 1. 61
31358409 2019
39
High-Complexity Plasmodium falciparum Infections, North Central Nigeria, 2015-2018. 61
31211682 2019
40
Novel variants of the newly emerged Anaplasma capra from Korean water deer (Hydropotes inermis argyropus) in South Korea. 61
31345253 2019
41
A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. 61
31346249 2019
42
Severe oxidative stress in sickle cell disease patients with uncomplicated Plasmodium falciparum malaria in Kampala, Uganda. 61
31288760 2019
43
The Diversity, Multiplicity of Infection and Population Structure of P. falciparum Parasites Circulating in Asymptomatic Carriers Living in High and Low Malaria Transmission Settings of Ghana. 61
31181699 2019
44
Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort. 61
31185998 2019
45
Immunomodulating effect of a seaweed extract from Ulva armoricana in pig: Specific IgG and total IgA in colostrum, milk, and blood. 61
32734073 2019
46
Immunization with merozoite surface protein 2 fused to a Plasmodium-specific carrier protein elicits strain-specific and strain-transcending, opsonizing antibody. 61
31227760 2019
47
Sub-microscopic Plasmodium falciparum infections in matched peripheral, placental and umbilical cord blood samples from asymptomatic Congolese women at delivery. 61
30836060 2019
48
Molecular Detection and Characterization of p44/msp2 Multigene Family of Anaplasma phagocytophilum from Haemaphysalis longicornis in Mie Prefecture, Japan. 61
30700658 2019
49
Bartonella and Rickettsia Infections in Haematophagous Spinturnix myoti Mites (Acari: Mesostigmata) and their Bat Host, Myotis myotis (Yangochiroptera: Vespertilionidae), from Poland. 61
30151669 2019
50
Diversity of Anaplasma species in cattle in Mozambique. 61
30833198 2019

Variations for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Expression for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Search GEO for disease gene expression data for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2.

Pathways for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

GO Terms for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Cellular components related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.44 XPO1 SARS1 NSL1 NANP HSPD1 GYPA

Biological processes related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein refolding GO:0042026 9.16 HSPD1 CCT7
2 selenocysteinyl-tRNA(Sec) biosynthetic process GO:0097056 8.96 SARS2 SARS1
3 seryl-tRNA aminoacylation GO:0006434 8.62 SARS2 SARS1

Molecular functions related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-tRNA ligase activity GO:0004828 8.62 SARS2 SARS1

Sources for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

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