MSP3
MCID: INC035
MIFTS: 26

Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 (MSP3)

Categories: Bone diseases, Genetic diseases, Mental diseases

Aliases & Classifications for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

MalaCards integrated aliases for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3:

Name: Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 12 15
Multisystem Proteinopathy 3 12
Ibmpfd3 12
Msp3 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0111386

Summaries for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Disease Ontology : 12 An inclusion body myopathy with Paget disease of bone and frontotemporal dementia that has material basis in heterozygous mutation in HNRNPA1 on chromosome 12q13.13.

MalaCards based summary : Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3, also known as multisystem proteinopathy 3, is related to malaria and inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2. An important gene associated with Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 is AKR1C2 (Aldo-Keto Reductase Family 1 Member C2). The drugs Aluminum hydroxide and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Diseases in the Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 family:

Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 2 Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 1

Diseases related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 malaria 29.3 SENP7 GYPA DHPS DHFR BSG AKR1C2
2 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 28.5 XPO1 SARS2 SARS1 RHAG GYPA DNAAF2
3 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 3 11.2
4 plasmodium falciparum malaria 10.2
5 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 10.1
6 tetanus 10.1
7 rh deficiency syndrome 10.1 RHAG GYPA
8 colorectal cancer, hereditary nonpolyposis, type 2 10.1 SURF4 DNAAF2 AKR1C2
9 hereditary elliptocytosis 10.0 RHAG GYPA ACKR1
10 otopalatodigital syndrome spectrum disorder 10.0 RHAG GYPA
11 rapidly involuting congenital hemangioma 9.9
12 pneumocystosis 9.9 DHPS DHFR
13 lynch syndrome i 9.8 SARS2 SARS1 AKR1C2
14 parasitic protozoa infectious disease 9.6 GYPA DHPS DHFR AKR1C2 ACKR1
15 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 1 9.0 XPO1 SENP7 RHAG GYPA DNAAF2 DHPS
16 inclusion body myopathy with paget disease of bone and frontotemporal dementia 7.7 XPO1 SENP7 SARS2 SARS1 RHAG HNRNPA2B1

Graphical network of the top 20 diseases related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3:



Diseases related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3

Symptoms & Phenotypes for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

GenomeRNAi Phenotypes related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-3 9.44 HNRNPA2B1
2 Decreased viability GR00221-A-4 9.44 HNRNPA2B1
3 Decreased viability GR00240-S-1 9.44 SARS1
4 Decreased viability GR00249-S 9.44 DHFR SARS2 SENP7
5 Decreased viability GR00381-A-1 9.44 DHFR
6 Decreased viability GR00386-A-1 9.44 GYPA HNRNPA2B1 XPO1
7 Decreased viability GR00402-S-2 9.44 HNRNPA2B1 SARS1 XPO1

Drugs & Therapeutics for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Drugs for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
2 Vaccines Phase 2
3 Immunologic Factors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase IIb Immunogenicity, Efficacy and Safety Study of P. Falciparum Vaccine Candidate, MSP3-LSP Adjuvanted in Aluminium Hydroxide Versus Verorab Control in Healthy Children Aged 12-48 Months in Mali. Unknown status NCT00652275 Phase 2
2 Phase 2B Double Blind, Randomized, Controlled Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of MSP3-LSP Vaccine Candidate Adjuvanted in Aluminium Hydroxide (AIOH) Against Plasmodium Falciparum Clinical Malaria in Healthy Children Aged 12-48 Months in Mali Completed NCT01341704 Phase 2
3 A Double Blind, Randomized, Controlled Phase Ib Field Trial in 12 to 24 Month Old Children in Tanzania to Evaluate the Safety and Immunogenicity of Candidate Malaria Vaccine MSP 3 Versus Hepatitis B Vaccine Unknown status NCT00469651 Phase 1
4 Assessment of the Safety and Immunogenicity of the Recombinant Lactococcus Lactis Hybrid GMZ2 [GLURP+MSP3] a Malaria Vaccine in Healthy Adult Volunteers. A Phase I, Double-Blind, Randomised, Dose-Selection, Unicentre Trial Unknown status NCT00397449 Phase 1

Search NIH Clinical Center for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3

Genetic Tests for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Anatomical Context for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

MalaCards organs/tissues related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3:

40
Bone

Publications for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Articles related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3:

(show top 50) (show all 139)
# Title Authors PMID Year
1
Does Antibody Avidity to Plasmodium falciparum Merozoite Antigens increase with Age in Individuals living in Malaria-Endemic Areas? 61
33722929 2021
2
Allelic variation of msp-3α gene in Plasmodium vivax isolates and its correlation with the severity of disease in vivax malaria. 61
32896637 2020
3
Conferring root-knot nematode resistance via host-delivered RNAi-mediated silencing of four Mi-msp genes in Arabidopsis. 61
32771150 2020
4
Insights into the molecular diversity of Plasmodium vivax merozoite surface protein-3γ (pvmsp3γ), a polymorphic member in the msp3 multi-gene family. 61
32620822 2020
5
Measuring antibody avidity to Plasmodium falciparum merozoite antigens using a multiplex immunoassay approach. 61
32357882 2020
6
Schistosoma haematobium infection modulates Plasmodium falciparum parasite density and antimalarial antibody responses. 61
32020650 2020
7
Stage-specific Plasmodium falciparum immune responses in afebrile adults and children living in the Greater Accra Region of Ghana. 61
32041620 2020
8
The immunoglobulin G antibody response to malaria merozoite antigens in asymptomatic children co-infected with malaria and intestinal parasites. 61
33170876 2020
9
Sero-diagnostic potential of Plasmodium falciparum recombinant merozoite surface protein (MSP)-3 expressed in silkworm. 61
31201923 2019
10
Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort. 61
31185998 2019
11
Immunomodulating effect of a seaweed extract from Ulva armoricana in pig: Specific IgG and total IgA in colostrum, milk, and blood. 61
32734073 2019
12
Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro. 61
30385417 2019
13
Analysis of antibody responses to selected Plasmodium falciparum merozoite surface antigens in mild and cerebral malaria and associations with clinical outcomes. 61
30580455 2019
14
Transcriptome profiling of Plasmodium vivax in Saimiri monkeys identifies potential ligands for invasion. 61
30872477 2019
15
A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01 E on blood stage immunity in young Kenyan children. 61
31168483 2019
16
Association of Antibodies to VAR2CSA and Merozoite Antigens with Pregnancy Outcomes in Women Living in Yaoundé, Cameroon. 61
29986889 2018
17
Plasmodium falciparum MSP3 Exists in a Complex on the Merozoite Surface and Generates Antibody Response during Natural Infection. 61
29760216 2018
18
Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission. 61
29217416 2018
19
Dynamics of anti-MSP3 and Pfs230 antibody responses and multiplicity of infection in asymptomatic children from southern Ghana. 61
29304870 2018
20
Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin. 61
28991911 2017
21
Statistical prediction of immunity to placental malaria based on multi-assay antibody data for malarial antigens. 61
28962616 2017
22
The GMZ2 malaria vaccine: from concept to efficacy in humans. 61
28699823 2017
23
Antibody responses to P. falciparum blood stage antigens and incidence of clinical malaria in children living in endemic area in Burkina Faso. 61
28886727 2017
24
Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite. 61
28646324 2017
25
Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana. 61
28835262 2017
26
An analytical approach to reduce between-plate variation in multiplex assays that measure antibodies to Plasmodium falciparum antigens. 61
28716094 2017
27
Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum. 61
28662682 2017
28
Whole-genome sequencing of a Plasmodium vivax clinical isolate exhibits geographical characteristics and high genetic variation in China-Myanmar border area. 61
28166727 2017
29
Individuals living in a malaria-endemic area of Cameroon do not have an acquired antibody response to Plasmodium falciparum histidine-rich protein 2. 61
28148260 2017
30
An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman. 61
28695821 2017
31
Genetic clustering and polymorphism of the merozoite surface protein-3 of Plasmodium knowlesi clinical isolates from Peninsular Malaysia. 61
28049516 2017
32
Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity. 61
27185785 2016
33
Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes. 61
26823464 2016
34
Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria. 61
26850066 2016
35
Dynamics and role of antibodies to Plasmodium falciparum merozoite antigens in children living in two settings with differing malaria transmission intensity. 61
26541134 2016
36
Neutralizing Antibodies against Plasmodium falciparum Associated with Successful Cure after Drug Therapy. 61
27427762 2016
37
The Plasmodium gaboni genome illuminates allelic dimorphism of immunologically important surface antigens in P. falciparum. 61
26296605 2015
38
Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3. 61
25889717 2015
39
[IgG responses to candidate malaria vaccine antigens in the urban area of Dakar (Senegal): evolution according to age and parasitemia in patients with mild symptoms]. 61
25925805 2015
40
Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? 61
25447268 2015
41
Parasite Specific Antibody Increase Induced by an Episode of Acute P. falciparum Uncomplicated Malaria. 61
25906165 2015
42
Genetic and genomic diversity studies of Acacia symbionts in Senegal reveal new species of Mesorhizobium with a putative geographical pattern. 61
25658650 2015
43
The origin and diversification of the merozoite surface protein 3 (msp3) multi-gene family in Plasmodium vivax and related parasites. 61
24862221 2014
44
Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria. 61
24980799 2014
45
New antigens for a multicomponent blood-stage malaria vaccine. 61
25080477 2014
46
A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. 61
24170322 2014
47
Sequential processing of merozoite surface proteins during and after erythrocyte invasion by Plasmodium falciparum. 61
24218484 2014
48
Plasmodium falciparum merozoite surface protein 3: oligomerization, self-assembly, and heme complex formation. 61
24362023 2014
49
Plasmodium falciparum malaria in children aged 0-2 years: the role of foetal haemoglobin and maternal antibodies to two asexual malaria vaccine candidates (MSP3 and GLURP). 61
25238160 2014
50
The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas. 61
23624363 2013

Variations for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Expression for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Search GEO for disease gene expression data for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3.

Pathways for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

GO Terms for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

Cellular components related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.36 XPO1 SURF4 SARS1 SAG RAP2A NUP42

Biological processes related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 translation GO:0006412 9.62 SARS2 SARS1 MRPL49 DHPS
2 viral process GO:0016032 9.55 XPO1 NUP42 HNRNPA2B1 GYPA BSG
3 mRNA transport GO:0051028 9.43 XPO1 NUP42 HNRNPA2B1
4 protein export from nucleus GO:0006611 9.37 XPO1 NUP42
5 selenocysteinyl-tRNA(Sec) biosynthetic process GO:0097056 8.96 SARS2 SARS1
6 seryl-tRNA aminoacylation GO:0006434 8.62 SARS2 SARS1

Molecular functions related to Inclusion Body Myopathy with Early-Onset Paget Disease of Bone with or Without Frontotemporal Dementia 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.11 XPO1 SURF4 SENP7 SARS2 SARS1 SAG
2 nuclear export signal receptor activity GO:0005049 8.96 XPO1 NUP42
3 serine-tRNA ligase activity GO:0004828 8.62 SARS2 SARS1

Sources for Inclusion Body Myopathy with Early-Onset Paget Disease of Bone...

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