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MCID: INC003
MIFTS: 43

Inclusion Conjunctivitis

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Inclusion Conjunctivitis

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MalaCards integrated aliases for Inclusion Conjunctivitis:

Name: Inclusion Conjunctivitis 12 76 53 15 73
Inclusion Conjunctivitis of the Adult 73
Neonatal Chlamydial Conjunctivitis 73
Adult Inclusion Conjunctivitis 12
Chlamydial Conjunctivitis 12
Conjunctivitis, Inclusion 44
Inclusion Blennorrhoea 12
Inclusion Blenorrhea 12
Paratrachoma 12

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Inclusion Conjunctivitis

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Disease Ontology : 12 A commensal bacterial infectious disease that results in inflammation, located in conjunctiva of the eye, has material basis in Chlamydia trachomatis, which is transmitted by sexual contact. The infection has symptom swollen conjunctiva and eyelids and has symptom discharge of pus and mucus.

MalaCards based summary : Inclusion Conjunctivitis, also known as inclusion conjunctivitis of the adult, is related to urethritis and salpingitis, and has symptoms including swollen conjunctiva and discharge of pus. An important gene associated with Inclusion Conjunctivitis is CD79A (CD79a Molecule), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Azithromycin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include conjunctiva of the eye, eye and testes.

Wikipedia : 76 Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the... more...

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Related Diseases for Inclusion Conjunctivitis

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Diseases related to Inclusion Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 urethritis 30.7 CD40LG CD79A
2 salpingitis 30.6 CD40LG CD79A OVGP1
3 selective igg deficiency disease 11.0 CD40LG CD79A
4 c1q nephropathy 11.0 CD40LG CD79A
5 meningovascular neurosyphilis 11.0 CD40LG CD79A
6 alpha chain disease 11.0 CD40LG CD79A
7 brill-zinsser disease 11.0 CD40LG CD79A
8 exudative glomerulonephritis 11.0 CD40LG CD79A
9 cork-handlers' disease 11.0 CD40LG CD79A
10 salpingo-oophoritis 11.0 CD40LG CD79A
11 early yaws 11.0 CD40LG CD79A
12 ventilation pneumonitis 11.0 CD40LG CD79A
13 chronic interstitial cystitis 11.0 CD40LG CD79A
14 axillary adenitis 11.0 CD40LG CD79A
15 cryofibrinogenemia 11.0 CD40LG CD79A
16 trichostrongyloidiasis 11.0 CD40LG CD79A
17 subacute bacterial endocarditis 11.0 CD40LG CD79A
18 heterophyiasis 11.0 CD40LG CD79A
19 immunoglobulin g deficiency 11.0 CD40LG CD79A
20 orbital granuloma 11.0 CD40LG CD79A
21 transient hypogammaglobulinemia of infancy 11.0 CD40LG CD79A
22 hyperglobulinemic purpura 10.9 CD40LG CD79A
23 gastroduodenitis 10.9 CD40LG CD79A
24 bacterial conjunctivitis 10.9 CD40LG CD79A
25 heavy chain disease 10.9 CD40LG CD79A
26 acrodermatitis chronica atrophicans 10.9 CD40LG OVGP1
27 immunoglobulin a deficiency 1 10.9 CD40LG CD79A
28 parotid disease 10.9 CD40LG CD79A
29 cerebral arteritis 10.9 CD40LG CD79A
30 selective immunoglobulin deficiency disease 10.9 CD40LG CD79A
31 geniculate herpes zoster 10.9 CD40LG CD79A
32 erythema elevatum diutinum 10.9 CD40LG CD79A
33 sporotrichosis 10.9 CD40LG CD79A
34 hyperimmunoglobulin syndrome 10.9 CD40LG CD79A
35 congenital syphilis 10.9 CD40LG CD79A
36 polyclonal hypergammaglobulinemia 10.9 CD40LG CD79A
37 monoclonal paraproteinemia 10.9 CD40LG CD79A
38 ocular toxoplasmosis 10.9 CD40LG CD79A
39 dysgammaglobulinemia 10.9 CD40LG CD79A
40 congenital hypogammaglobulinemia 10.9 CD40LG CD79A
41 acute maxillary sinusitis 10.9 CD40LG CD79A
42 chronic polyneuropathy 10.9 CD40LG CD79A
43 spinocerebellar ataxia, autosomal recessive 10 10.9 CD40LG CD79A
44 parasitic ichthyosporea infectious disease 10.9 CD40LG CD79A
45 cd40 ligand deficiency 10.9 CD40LG CD79A
46 rhinosporidiosis 10.9 CD40LG CD79A
47 secondary syphilis 10.9 CD40LG CD79A
48 yellow nail syndrome 10.8 CD40LG CD79A
49 congenital toxoplasmosis 10.8 CD40LG CD79A
50 chorioretinitis 10.8 CD40LG CD79A

Graphical network of the top 20 diseases related to Inclusion Conjunctivitis:



Diseases related to Inclusion Conjunctivitis
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Symptoms & Phenotypes for Inclusion Conjunctivitis

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Symptoms:

12
  • • swollen conjunctiva
  • • discharge of pus
Sources

Drugs & Therapeutics for Inclusion Conjunctivitis

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Drugs for Inclusion Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
2
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
5
Ivermectin Approved, Investigational, Vet_approved Phase 4,Not Applicable 70288-86-7 6474909
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
7
Sulfamethoxazole Approved Phase 4 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
9 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
10 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
11 Anti-Infective Agents Phase 4,Not Applicable
12 Anthelmintics Phase 4,Not Applicable
13 Antimitotic Agents Phase 4,Not Applicable
14 Antiparasitic Agents Phase 4,Not Applicable
15 Antiprotozoal Agents Phase 4,Not Applicable
16 Antitubercular Agents Phase 4
17 Antimalarials Phase 4
18 Renal Agents Phase 4
19 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
20 Ophthalmic Solutions Phase 3,Not Applicable
21 Pharmaceutical Solutions Phase 3,Not Applicable
22 Tetrahydrozoline Phase 3,Not Applicable
23
Menthol Approved Not Applicable 2216-51-5 16666
24
Fluorometholone Approved, Investigational Not Applicable 426-13-1 9878
25 Anti-Allergic Agents Not Applicable
26 Anti-Inflammatory Agents Not Applicable
27 glucocorticoids Not Applicable
28 Hormone Antagonists Not Applicable
29 Hormones Not Applicable
30 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
31 Lubricant Eye Drops Not Applicable

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
2 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
3 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
4 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
5 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
6 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
7 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
8 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
9 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
10 Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia Completed NCT00347776 Phase 4 azithromycin;topical tetracycline
11 Mortality Reduction After Oral Azithromycin: Morbidity Study Completed NCT02048007 Phase 4 Azithromycin;Placebo
12 Mortality Reduction After Oral Azithromycin: Mortality Study Completed NCT02047981 Phase 4 Azithromycin;Placebo
13 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
14 Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children Recruiting NCT02414399 Phase 4 Azithromycin;Placebo
15 Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso Active, not recruiting NCT03187834 Phase 4 Azithromycin;Amoxicillin;Cotrimoxazole;Placebo
16 Kebele Elimination of Trachoma for Ocular Health Not yet recruiting NCT03335072 Phase 4 Azithromycin
17 Trachoma Elimination Study by Focused Antibiotic (TESFA) Not yet recruiting NCT03523156 Phase 4 Azithromycin mass treatment;Azithromycin targeted treatment
18 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
19 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
20 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
21 Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma Completed NCT00356720 Phase 3 Azithromycin
22 Prevention of Bacterial Infections in Newborn Completed NCT01800942 Phase 3 Azithromycin and Placebo
23 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
24 Nepal Elimination of Trachoma Study Withdrawn NCT02176057 Phase 2, Phase 3 Azithromycin
25 The Effect of Oral Azithromycin in the Treatment of Chlamydial Conjunctivitis Completed NCT01178762 Not Applicable Azithromycin
26 A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial Completed NCT01767506 Not Applicable
27 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015 Not Applicable
28 Water Uptake for Health in Amhara Pilot Completed NCT02373657 Not Applicable
29 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169 Not Applicable triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
30 Identification of TT Cases by Community Treatment Assistants: An Assessment Completed NCT01783743 Not Applicable
31 Fluorometholone as Ancillary Therapy for TT Surgery Completed NCT01949454 Not Applicable Fluorometholone 0.1% ophthalmic solution
32 The Effect of Long-Term HEAD START Training on Surgical Skill Levels Completed NCT03135080 Not Applicable
33 A Trial of Epilation Verses Surgery for Minor Trichiasis Completed NCT00522912 Not Applicable
34 Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze Completed NCT00439114
35 Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population Withdrawn NCT02655432

Search NIH Clinical Center for Inclusion Conjunctivitis

Cochrane evidence based reviews: conjunctivitis, inclusion

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Genetic Tests for Inclusion Conjunctivitis

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Anatomical Context for Inclusion Conjunctivitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Inclusion Conjunctivitis:

19
Conjunctiva Of The Eye

MalaCards organs/tissues related to Inclusion Conjunctivitis:

41
Eye, Testes
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Publications for Inclusion Conjunctivitis

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Articles related to Inclusion Conjunctivitis:

(show top 50) (show all 109)
# Title Authors Year
1
Conjunctival infection with Chlamydia trachomatis in sexual partners of patients with adult inclusion conjunctivitis. ( 24643518 )
2014
2
Evaluation of single-dose azithromycin versus standard azithromycin/doxycycline treatment and clinical assessment of regression course in patients with adult inclusion conjunctivitis. ( 24047438 )
2013
3
Evaluation of direct immunofluorescence assay and cytological examination in comparison to polymerase chain reaction of conjunctival swabs in patients with adult inclusion conjunctivitis. ( 23627371 )
2013
4
Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis. ( 22144478 )
2012
5
Combination of adult inclusion conjunctivitis and mucosa-associated lymphoid tissue (MALT) lymphoma in a young adult. ( 14701961 )
2004
6
Azithromycin vs doxycycline in the treatment of inclusion conjunctivitis. ( 12654359 )
2003
7
Phage infection of the obligate intracellular bacterium, Chlamydia psittaci strain guinea pig inclusion conjunctivitis. ( 10955956 )
2000
8
Microvirus of chlamydia psittaci strain guinea pig inclusion conjunctivitis: isolation and molecular characterization. ( 10878129 )
2000
9
Homologs of Escherichia coli recJ, gltX and of a putative 'early' gene of avian Chlamydia psittaci are located upstream of the 'late' omp2 locus of Chlamydia psittaci strain guinea pig inclusion conjunctivitis. ( 8918248 )
1996
10
Serotyping of Chlamydia trachomatis from inclusion conjunctivitis by polymerase chain reaction and restriction fragment length polymorphism analysis. ( 8876399 )
1996
11
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. ( 8919742 )
1996
12
Evaluation of the Kodak Surecell Chlamydia test for the laboratory diagnosis of adult inclusion conjunctivitis. ( 9121749 )
1995
13
Increased incidence of oviduct pathology in the guinea pig after repeat vaginal inoculation with the chlamydial agent of guinea pig inclusion conjunctivitis. ( 7709325 )
1995
14
Dissociation of immune determinants of outer membrane proteins of Chlamydia psittaci strain guinea pig inclusion conjunctivitis. ( 7525489 )
1994
15
Diagnosing inclusion conjunctivitis. ( 7852700 )
1994
16
Partial protection against genital reinfection by immunization of guinea-pigs with isolated outer-membrane proteins of the chlamydial agent of guinea-pig inclusion conjunctivitis. ( 7510322 )
1993
17
Lack of allelic polymorphism for the major outer membrane protein gene of the agent of guinea pig inclusion conjunctivitis (Chlamydia psittaci). ( 8514416 )
1993
18
Monoclonal antibodies to Chlamydia psittaci guinea pig inclusion conjunctivitis (GPIC) strain. ( 2186565 )
1990
19
Role of cell-mediated immunity in the resolution of secondary chlamydial genital infection in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis. ( 2917782 )
1989
20
Ultrastructural studies on the intracellular fate of Chlamydia psittaci (strain guinea pig inclusion conjunctivitis) and Chlamydia trachomatis (strain lymphogranuloma venereum 434): modulation of intracellular events and relationship with endocytic mechanism. ( 2614396 )
1989
21
Guineapig inclusion conjunctivitis (GPIC) in a commercial colony. ( 2651796 )
1989
22
Persistence of inclusion conjunctivitis after oral erythromycin therapy. ( 3179892 )
1988
23
Regulation of Chlamydia psittaci (strain guinea pig inclusion conjunctivitis) growth in McCoy cells by amino acid antagonism. ( 3655729 )
1987
24
Electron microscopic observations concerning the in vivo uptake and release of the agent of guinea-pig inclusion conjunctivitis (Chlamydia psittaci) in guinea-pig exocervix. ( 4031129 )
1985
25
A study of inclusion conjunctivitis in newborn and young adults. Clinical picture, culture, conjunctival scrapings and cytology of the tear fluid in 12 cases. ( 6362323 )
1983
26
Differential amino acid utilization by Chlamydia psittaci (strain guinea pig inclusion conjunctivitis) and its regulatory effect on chlamydial growth. ( 6415225 )
1983
27
Chlamydial inclusion conjunctivitis of the newborn. ( 6834172 )
1983
28
Serum and tear antibodies to Chlamydia after reinfection with guinea pig inclusion conjunctivitis agent. ( 7031009 )
1981
29
'Innocent' neonatal inclusion conjunctivitis: parental origins and complications. ( 21289694 )
1981
30
Cell-mediated and humoral immune responses to chlamydial antigens in guinea pigs infected ocularly with the agent of guinea pig inclusion conjunctivitis. ( 7012031 )
1981
31
Adult inclusion conjunctivitis. Clinical characteristics and corneal changes. ( 7224930 )
1981
32
Ocular and dermal delayed hypersensitivity reactions in guinea-pigs following infection with guinea-pig inclusion conjunctivitis agent (Chlamydia psittaci). ( 7261478 )
1981
33
Guinea-pig inclusion conjunctivitis as a model for the study of trachoma: clinical, microbiological, serological, and cytological studies of primary infection. ( 7387961 )
1980
34
Target tissues associated with genital infection of female guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis. ( 374637 )
1979
35
Experimental chlamydial salpingitis in immunosuppressed guinea pigs infected in the genital tract with the agent of guinea pig inclusion conjunctivitis. ( 397933 )
1979
36
Humoral immunity in the resolution of genital infection in female guinea pigs infected with the agent of guinea pig inclusion conjunctivitis. ( 546788 )
1979
37
Immunity to vaginal reinfection in female guinea pigs infected sexually with Chlamydia of guinea pig inclusion conjunctivitis. ( 640729 )
1978
38
Staphylococcal infection superimposed on guinea pig inclusion conjunctivitis. ( 638844 )
1978
39
Resistance to reinfection with a chlamydial agent (guinea pig inclusion conjunctivitis agent). ( 863616 )
1977
40
Limited survey of genital infection by guinea pig inclusion conjunctivitis agent. ( 921034 )
1977
41
Severe persistent inclusion conjunctivitis in a young child. ( 848548 )
1977
42
Infectivity titration of guinea-pig inclusion conjunctivitis agent in irradiated McCoy cells. ( 986419 )
1976
43
Intrarectal infection of guinea pigs with the agent of guinea pig inclusion conjunctivitis. ( 1013148 )
1976
44
Animal model studies of genital chlamydial infections. Immunity to re-infection with guinea-pig inclusion conjunctivitis agent in the urethra and eye of male guinea-pigs. ( 963491 )
1976
45
Ultrastructural study of trachoma and inclusion conjunctivitis. ( 1028127 )
1976
46
The effect of cyclophosphamide on the recovery from a local chlamydial infection. Guinea-pig inclusion conjunctivitis (GPIC). ( 1088418 )
1976
47
Three new immunologic types of trachoma-inclusion conjunctivitis organisms. ( 4631875 )
1973
48
Immunity to chlamydial infections of the eye. II. Studies of passively transferred serum antibody in resistance to infection with guinea pig inclusion conjunctivitis. ( 4586860 )
1973
49
A simplified method for immunological typing of trachoma-inclusion conjunctivitis-lymphogranuloma venereum organisms. ( 16558075 )
1973
50
Effect of polycations, polyanions and neuraminidase on the infectivity of trachoma-inclusin conjunctivitis and lymphogranuloma venereum organisms HeLa cells: sialic acid residues as possible receptors for trachoma-inclusion conjunction. ( 4718924 )
1973
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Variations for Inclusion Conjunctivitis

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Expression for Inclusion Conjunctivitis

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Search GEO for disease gene expression data for Inclusion Conjunctivitis.
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Pathways for Inclusion Conjunctivitis

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Pathways related to Inclusion Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.44 CCL5 CD40LG CD79A TXN
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GO Terms for Inclusion Conjunctivitis

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Biological processes related to Inclusion Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-12 production GO:0032735 9.37 CD40LG HMGB1
2 positive regulation of interleukin-10 production GO:0032733 9.32 CD40LG HMGB1
3 positive regulation of innate immune response GO:0045089 9.26 CCL5 HMGB1
4 positive regulation of monocyte chemotaxis GO:0090026 9.16 CCL5 HMGB1
5 regulation of signaling receptor activity GO:0010469 9.02 CCL5 CD40LG HMGB1 IL16 TXLNA
6 dendritic cell chemotaxis GO:0002407 8.96 CCL5 HMGB1

Molecular functions related to Inclusion Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 CD40LG HMGB1 IL16 TXLNA
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Sources for Inclusion Conjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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