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MCID: INC003
MIFTS: 37

Inclusion Conjunctivitis

Categories: Eye diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Inclusion Conjunctivitis

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MalaCards integrated aliases for Inclusion Conjunctivitis:

Name: Inclusion Conjunctivitis 12 74 52 15 17 71
Chlamydial Conjunctivitis 12 32
Inclusion Conjunctivitis of the Adult 71
Neonatal Chlamydial Conjunctivitis 71
Adult Inclusion Conjunctivitis 12
Conjunctivitis, Inclusion 43
Inclusion Blennorrhoea 12
Inclusion Blenorrhea 12
Paratrachoma 12

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:13800
ICD9CM 34 077.0
MeSH 43 D003235
SNOMED-CT 67 56009001
ICD10 32 A74.0
UMLS 71 C0009770 C0343723 C0392644
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Summaries for Inclusion Conjunctivitis

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Disease Ontology : 12 A commensal bacterial infectious disease that results in inflammation, located in conjunctiva of the eye, has material basis in Chlamydia trachomatis, which is transmitted by sexual contact. The infection has symptom swollen conjunctiva and eyelids and has symptom discharge of pus and mucus.

MalaCards based summary : Inclusion Conjunctivitis, also known as chlamydial conjunctivitis, is related to bacterial conjunctivitis and conjunctival folliculosis, and has symptoms including swollen conjunctiva and discharge of pus. An important gene associated with Inclusion Conjunctivitis is NAT9 (N-Acetyltransferase 9 (Putative)). The drugs silver nitrate and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include conjunctiva of the eye, eye and testes.

Wikipedia : 74 Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the... more...

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Related Diseases for Inclusion Conjunctivitis

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Diseases related to Inclusion Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 bacterial conjunctivitis 30.1 NAT9 CD40LG
2 conjunctival folliculosis 30.1 PLD3 NAT9
3 lymphogranuloma venereum 30.0 NAT9 ESCO2 CPN1
4 ornithosis 30.0 NAT9 ESCO2 CD40LG
5 cat-scratch disease 29.8 HSPD1 CD40LG
6 acute hemorrhagic conjunctivitis 29.7 PLD3 CD40LG
7 cervicitis 29.4 NAT9 HSPD1 ESCO2
8 urethritis 29.3 NAT9 HSPD1 ESCO2 CD40LG
9 chlamydia pneumonia 29.2 HSPD1 CPN1 CD40LG
10 salpingitis 29.1 NAT9 HSPD1 ESCO2 CD40LG
11 conjunctivitis 10.9
12 trachoma 10.6
13 chlamydia 10.6
14 ross river fever 10.3 NAT9 CD40LG
15 chronic polyneuropathy 10.3 WDR13 CD40LG
16 epididymis disease 10.3 NAT9 CD40LG
17 fallopian tube disease 10.2 NAT9 CD40LG
18 chronic conjunctivitis 10.1
19 ophthalmia neonatorum 10.1
20 pure red-cell aplasia 10.1 OXA1L CD40LG
21 drug allergy 10.1 OXA1L CD40LG
22 japanese spotted fever 10.0 HSPD1 CD40LG
23 keratitis, hereditary 10.0
24 chancroid 10.0 HSPD1 CD40LG
25 pyelitis 10.0 CPN1 CD40LG
26 cervical adenitis 10.0 HSPD1 CD40LG
27 bartonellosis 10.0 HSPD1 CD40LG
28 rocky mountain spotted fever 10.0 HSPD1 CD40LG
29 human granulocytic anaplasmosis 10.0 HSPD1 CD40LG
30 tularemia 10.0 HSPD1 CD40LG
31 primary systemic mycosis 10.0 HSPD1 CD40LG
32 hand skill, relative 10.0
33 ptosis 10.0
34 bacterial infectious disease 10.0
35 pyloric stenosis 10.0
36 uveitis 10.0
37 chronic follicular conjunctivitis 10.0
38 cellulitis 10.0
39 gastritis 10.0
40 reactive arthritis 10.0
41 gastrointestinal system disease 10.0
42 arthritis 10.0
43 herpes simplex 10.0
44 chickenpox 10.0
45 cytokine deficiency 10.0
46 ehrlichiosis 9.9 HSPD1 CD40LG
47 acute disseminated encephalomyelitis 9.9 HSPD1 CD40LG
48 endocardium disease 9.9 HSPD1 CD40LG
49 granuloma inguinale 9.9 NAT9 ESCO2 CPN1
50 acute cystitis 9.9 OXA1L CD40LG

Graphical network of the top 20 diseases related to Inclusion Conjunctivitis:



Diseases related to Inclusion Conjunctivitis
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Symptoms & Phenotypes for Inclusion Conjunctivitis

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Symptoms:

12
  • • swollen conjunctiva
  • • discharge of pus
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Drugs & Therapeutics for Inclusion Conjunctivitis

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Drugs for Inclusion Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 silver nitrate Approved, Investigational Phase 3
2
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560 441411
3
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
5
Povidone Approved Phase 3 9003-39-8
6
Iodine Approved, Investigational Phase 3 7553-56-2 807
7
Povidone-iodine Approved Phase 3 25655-41-8
8 Erythromycin Ethylsuccinate Phase 3
9 Erythromycin stearate Phase 3
10 Erythromycin Estolate Phase 3
11 Anti-Bacterial Agents Phase 3
12 Pharmaceutical Solutions Phase 3
13 Ophthalmic Solutions Phase 3
14 Antiemetics Phase 3
15 Gastrointestinal Agents Phase 3
16 Hormone Antagonists Phase 3
17 Anti-Inflammatory Agents Phase 3
18 BB 1101 Phase 3
19 Autonomic Agents Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21 glucocorticoids Phase 3
22 Hormones Phase 3
23 cadexomer iodine Phase 3
24 Anti-Infective Agents Phase 3
25 Anti-Infective Agents, Local Phase 3
26 Antiviral Agents Phase 2
27 HIV Protease Inhibitors Phase 2
28
protease inhibitors Phase 2
29
Azithromycin Approved 83905-01-5 55185 447043

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
2 A Phase 3, Multi-center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of SHP640 (PVP-Iodine 0.6% and Dexamethasone 0.1%) Ophthalmic Suspension Compared to Placebo in the Treatment of Adenoviral Conjunctivitis Terminated NCT02998554 Phase 3 SHP640;Placebo
3 A Phase 3, Multi-center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of SHP640 (PVP-Iodine 0.6% and Dexamethasone 0.1%) Ophthalmic Suspension Compared to PVP-Iodine and Placebo in the Treatment of Adenoviral Conjunctivitis Terminated NCT02998541 Phase 3 SHP640;PVP-I 0.6%
4 A Proof-of-Concept, Multi-center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of FST-100 Ophthalmic Suspension in the Treatment of Acute Adenoviral Conjunctivitis Completed NCT01470664 Phase 2 FST-100;FST-100 (Component #1);FST-100 Vehicle
5 A Multicenter, Randomized Study of the Efficacy and Safety of NVC-422 Ophthalmic Solution for the Treatment of Adenoviral Conjunctivitis Completed NCT01532336 Phase 2 NVC-422 Solution, 0.3%;NVC-422 Vehicle Solution
6 A Phase 2, Multi-centeR, Randomized, DoUBle-Masked, Placebo-Controlled StudY to Evaluate the Clinical Safety and Efficacy of OKG-0301 in the Treatment of Acute Adenoviral Conjunctivitis Recruiting NCT03856645 Phase 2 OKG-0301
7 A Double-Masked, Placebo-Controlled, Randomized, Phase II Clinical Trial To Assess The Efficacy Of IVIEW-1201 In The Treatment Of Acute Adenoviral Conjunctivitis Not yet recruiting NCT03749317 Phase 2 IVIEW-1201;Placebo
8 An Evaluation of the Efficacy and Safety of AL-46383A Ophthalmic Solution for the Treatment of Adenoviral Conjunctivitis Terminated NCT00901693 Phase 2 AL-46383A Ophthalmic Solution;AL-46383A Ophthalmic Solution Vehicle
9 FST-100 Ophthalmic Suspension in Acute Adenoviral Conjunctivitis Terminated NCT00941486 Phase 2 FST-100 (0.1% dexamethasone) Ophthalmic Suspension;Placebo
10 The Effect of Oral Azithromycin in the Treatment of Chlamydial Conjunctivitis Completed NCT01178762 Azithromycin
11 A Prospective Blinded Multi-center Clinical Trial to Evaluate the Efficacy of the Recently FDA Approved RPS Adeno Detector for Detecting Adenoviral Conjunctivitis Completed NCT00266734

Search NIH Clinical Center for Inclusion Conjunctivitis

Cochrane evidence based reviews: conjunctivitis, inclusion

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Genetic Tests for Inclusion Conjunctivitis

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Anatomical Context for Inclusion Conjunctivitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Inclusion Conjunctivitis:

19
Conjunctiva Of The Eye

MalaCards organs/tissues related to Inclusion Conjunctivitis:

40
Eye, Testes, T Cells, Skeletal Muscle, Colon, Neutrophil, Lymph Node
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Publications for Inclusion Conjunctivitis

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Articles related to Inclusion Conjunctivitis:

(show top 50) (show all 409)
# Title Authors PMID Year
1
Chlamydia trachomatis presenting as preseptal cellulitis in a 3-year-old girl. 61
31112775 2019
2
Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae. 61
31697687 2019
3
Symptoms, Signs and Long-term Prognosis of Vertically Transmitted Chlamydia trachomatis Infections. 61
29389825 2018
4
Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis. 61
30007329 2018
5
Effects of iota-carrageenan on ocular Chlamydia trachomatis infection in vitro and in vivo. 61
30147240 2018
6
Interventions for treating genital Chlamydia trachomatis infection in pregnancy. 61
28937705 2017
7
Neonatal Bacterial Conjunctivitis in Korea in the 21st Century. 61
28002109 2017
8
Chlamydial conjunctivitis in newborns: Case report and screening opportunities. 61
28177584 2017
9
Chlamydial eye infections: Current perspectives. 61
28345563 2017
10
[Persistent, therapy-resistant conjunctivitis: consider infection with Chlamydia trachomatis]. 61
28443807 2017
11
The presence of Chlamydia phage PhiCPG1 capsid protein VP1 genes and antibodies in patients infected with Chlamydia trachomatis. 61
27213552 2016
12
Study of the prevalence and association of ocular chlamydial conjunctivitis in women with genital infection by Chlamydia trachomatis, Mycoplasma genitalium and Candida albicans attending outpatient clinic. 61
27588273 2016
13
Chlamydial conjunctivitis: prevalence and serovar distribution of Chlamydia trachomatis in adults. 61
26297635 2015
14
Preventing ophthalmia neonatorum. 61
26236350 2015
15
Conjunctival infection with Chlamydia trachomatis in sexual partners of patients with adult inclusion conjunctivitis. 61
24643518 2015
16
Preventing ophthalmia neonatorum. 61
25838784 2015
17
Chlamydia trachomatis conjunctivitis in a male teenager: a case report. 61
24955802 2014
18
Evaluation of single-dose azithromycin versus standard azithromycin/doxycycline treatment and clinical assessment of regression course in patients with adult inclusion conjunctivitis. 61
24047438 2013
19
Evaluation of direct immunofluorescence assay and cytological examination in comparison to polymerase chain reaction of conjunctival swabs in patients with adult inclusion conjunctivitis. 61
23627371 2013
20
Multiplex PCR testing requires a robust multi-disciplinary strategy to effectively manage identified cases of chlamydial conjunctivitis. 61
23728751 2013
21
[Purulent keratoconjunctivitis due to Neisseria gonorrhoeae and Chlamydia trachomatis coinfection]. 61
23692878 2013
22
[Investigation of Chlamydia trachomatis with Cell Culture, DFA and PCR Methods in the Genital Swab Samples of Symptomatic Patients]. 61
23390905 2013
23
[Prevalence of Chlamydia trachomatis in adults with chronic conjunctivitis in Nisava district]. 61
22650098 2012
24
The use of polymerase chain reaction assay versus cell culture in detecting neonatal chlamydial conjunctivitis. 61
22369307 2012
25
Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis. 61
22144478 2012
26
Features and serotypes of chlamydial conjunctivitis. 61
22230301 2012
27
Essential role for neutrophils in pathogenesis and adaptive immunity in Chlamydia caviae ocular infections. 61
21402767 2011
28
Effect of oral azithromycin in the treatment of chlamydial conjunctivitis. 61
19893589 2010
29
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. 61
20523096 2010
30
Midterm results of cultivated autologous and allogeneic limbal epithelial transplantation in limbal stem cell deficiency. 61
20502027 2010
31
Chlamydia trachomatis causing neonatal conjunctivitis in a tertiary care center. 61
20061763 2010
32
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital. 61
18093859 2008
33
The use of polymerase chain reaction assay versus conventional methods in detecting neonatal chlamydial conjunctivitis. 61
18705621 2008
34
Bacterial conjunctivitis: a review for internists. 61
18646586 2008
35
Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico. 61
17947266 2007
36
Chlamydial conjunctivitis presenting as pre septal cellulitis. 61
17359543 2007
37
Incidence of neonatal chlamydial conjunctivitis and its association with nasopharyngeal colonisation in a Hong Kong hospital, assessed by polymerase chain reaction. 61
17277388 2007
38
Can chlamydial conjunctivitis result from direct ejaculation into the eye? 61
16942659 2006
39
Otitis media in adults with chlamydial conjunctivitis. 61
16731671 2006
40
Neonatal chlamydial conjunctivitis. 61
16760561 2006
41
Chlamydiales in guinea-pigs and their zoonotic potential. 61
16629952 2006
42
Neonatal haemorrhagic conjunctivitis: a specific sign of chlamydial infection. 61
16495586 2006
43
Chlamydia trachomatis infections in neonates and young children. 61
16210104 2005
44
The Relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). 61
16088243 2005
45
Conjunctival swab cytology from a guinea pig: it's elementary! 61
15902672 2005
46
Feline chlamydiosis. 61
15948428 2005
47
Cell death, BAX activation, and HMGB1 release during infection with Chlamydia. 61
15488733 2004
48
Chronic penile oedema secondary to chronic masturbation. 61
15228737 2004
49
Current problems of perinatal Chlamydia trachomatis infections. 61
14962349 2004
50
Combination of adult inclusion conjunctivitis and mucosa-associated lymphoid tissue (MALT) lymphoma in a young adult. 61
14701961 2004
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Variations for Inclusion Conjunctivitis

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Expression for Inclusion Conjunctivitis

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Search GEO for disease gene expression data for Inclusion Conjunctivitis.
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Pathways for Inclusion Conjunctivitis

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GO Terms for Inclusion Conjunctivitis

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Cellular components related to Inclusion Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 site of double-strand break GO:0035861 8.62 ESCO2 ARPC2

Biological processes related to Inclusion Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.26 HSPD1 CD40LG
2 B cell activation GO:0042113 9.16 TXLNA HSPD1
3 positive regulation of interleukin-12 production GO:0032735 8.96 HSPD1 CD40LG
4 positive regulation of interleukin-10 production GO:0032733 8.62 HSPD1 CD40LG
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Sources for Inclusion Conjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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