MCID: IND004
MIFTS: 27

Indeterminate Leprosy

Categories: Endocrine diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Indeterminate Leprosy

MalaCards integrated aliases for Indeterminate Leprosy:

Name: Indeterminate Leprosy 12 15 71 32
Uncharacteristic Leprosy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11851
ICD9CM 34 030.2
SNOMED-CT 67 14386001
ICD10 32 A30.0
UMLS 71 C0021192

Summaries for Indeterminate Leprosy

Disease Ontology : 12 A leprosy that is an early form of the disease which causes one to a few hypopigmented or erythematous macules.

MalaCards based summary : Indeterminate Leprosy, also known as uncharacteristic leprosy, is related to leprosy 3 and hansen's disease. An important gene associated with Indeterminate Leprosy is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways is Defensins. Affiliated tissues include skin and lymph node, and related phenotype is Decreased hepcidin::fluc mRNA expression.

Related Diseases for Indeterminate Leprosy

Graphical network of the top 20 diseases related to Indeterminate Leprosy:



Diseases related to Indeterminate Leprosy

Symptoms & Phenotypes for Indeterminate Leprosy

GenomeRNAi Phenotypes related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased hepcidin::fluc mRNA expression GR00253-A 8.8 RIPK2 SLC11A1 TLR1

Drugs & Therapeutics for Indeterminate Leprosy

Search Clinical Trials , NIH Clinical Center for Indeterminate Leprosy

Genetic Tests for Indeterminate Leprosy

Anatomical Context for Indeterminate Leprosy

MalaCards organs/tissues related to Indeterminate Leprosy:

40
Skin, Lymph Node

Publications for Indeterminate Leprosy

Articles related to Indeterminate Leprosy:

(show top 50) (show all 140)
# Title Authors PMID Year
1
Masquerading presentation of morphea as hypopigmented patch mimicking indeterminate leprosy. 61
33259054 2020
2
Nevus depigmentosus: review of a mark of distinction. 61
30801693 2019
3
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil. 61
30629624 2019
4
Leprosy Associated with Atypical Cutaneous Leishmaniasis in Nicaragua and Honduras. 61
29031287 2017
5
Leprosy in an Eight-Year-Old Child - An Exceptional Case with Unusual Oral Manifestation. 61
28571290 2017
6
Analysis of a novel multiplex polymerase chain reaction assay as a sensitive tool for the diagnosis of indeterminate and tuberculoid forms of leprosy. 61
28317797 2017
7
Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients. 61
27163568 2016
8
Dermal dendrocytes FXIIIa+ are essential antigen-presenting cells in indeterminate leprosy. 61
25365500 2015
9
Clinical aspects of leprosy. 61
25432808 2015
10
Leprosy Scenario at a Tertiary Level Hospital in Delhi: A 5-year Retrospective Study. 61
25657398 2015
11
Childhood leprosy through the post-leprosy-elimination era: a retrospective analysis of epidemiological and clinical characteristics of disease over eleven years from a tertiary care hospital in North India. 61
25675654 2014
12
Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City. 61
26411247 2014
13
Childhood leprosy: a retrospective descriptive study from Government Medical College, Kozhikode, Kerala, India. 61
25255613 2014
14
Role of s-100 immunostaining in demonstration of nerve changes and quantification of dendritic cells in leprosy. 61
24783075 2014
15
Clinical profile of leprosy patients: a prospective study. 61
24700934 2014
16
Indeterminate leprosy and lepromatous index case: four cases in the same family. 61
24346893 2013
17
A study of histopathology of clinically normal appearing skin in the tuberculoid spectrum of leprosy. 61
24834636 2013
18
Frequencies of MICA alleles in patients from southern Brazil with multibacillary and paucibacillary leprosy. 61
22168250 2012
19
Cojedes: a leprosy hyperendemic state. 61
22250629 2012
20
[A man with a white macula]. 61
23075772 2012
21
Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort. 61
22180790 2011
22
[Evaluation years in leprosy patients treated with single dose alternative scheme ROM (rifampin, ofloxacin, minocycline), after seven to nine]. 61
21181026 2010
23
Risk factors for physical disability at diagnosis of 19,283 new cases of leprosy. 61
20305962 2010
24
Histopathological lesions of apparently normal skin in leprosy patients. 61
20120756 2009
25
Clinico-epidemiological trends of leprosy in Himachal Pradesh: a five year study. 61
20704072 2009
26
Leprosy: a diagnostic trap for dermatopathologists in nonendemic area. 61
19590409 2009
27
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. 61
19460328 2009
28
Inoculation indeterminate leprosy localised to a smallpox vaccination scar. 61
18309715 2007
29
Angiogenesis in cutaneous lesions of leprosy: implications for treatment. 61
18087002 2007
30
Leprosy in a preschool child--a case report. 61
17824468 2007
31
Indeterminate leprosy in an infant. 61
17343225 2006
32
S-100 as a useful auxiliary diagnostic aid in tuberculoid leprosy. 61
16872470 2006
33
[Conjugal leprosy]. 61
16925119 2006
34
Evaluation of leprosy patients with 1 to 5 skin lesions with relevance to their grouping into paucibacillary or multibacillary disease. 61
16766835 2006
35
Histopathological study of apparently normal skin of patients with leprosy. 61
16533232 2006
36
Leprosy in the Department of Dermatology, Chang Gung Memorial Hospital at Kaohsiung from 1988 to 2004: a clinical and histopathologic study of 13 cases. 61
16382756 2005
37
Ulnar nerve abscess and relapse in a patient with indeterminate leprosy 1 year after completion of multidrug therapy. 61
15995337 2005
38
[Relapses after multibacillary leprosy treatment]. 61
15495593 2004
39
[Two cases of Hansen's disease]. 61
14598638 2003
40
Detection of Mycobacterium leprae DNA by polymerase chain reaction in the blood of individuals, eight years after completion of anti-leprosy therapy. 61
11784934 2001
41
Indeterminate leprosy, molluscum contagiosum and nevus depigmentosus. 61
11898470 2001
42
Lucio leprosy with lucio phenomenon. 61
11840599 2001
43
Mast cells in leprosy skin lesions. 61
11355515 2001
44
Leprosy. Recognition and treatment. 61
11705247 2001
45
Immuno-histopathology in the diagnosis of early leprosy. 61
11332285 2000
46
Distinct patterns of microvasculature in the cutaneous lesions of leprosy. 61
11036494 2000
47
Delay in diagnosis: indeterminate leprosy presenting with rheumatic manifestations. 61
10689224 2000
48
Significance of histopathological classification in leprosy. 61
10626238 1999
49
Histological studies in primary neuritic leprosy: changes in the apparently normal skin. 61
9927807 1998
50
Concomitant kala-azar, malaria, and progressive unstable indeterminate leprosy in an 8-year-old child. 61
9718914 1998

Variations for Indeterminate Leprosy

Expression for Indeterminate Leprosy

Search GEO for disease gene expression data for Indeterminate Leprosy.

Pathways for Indeterminate Leprosy

Pathways related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 TLR1 SLC11A1 DEFB1

GO Terms for Indeterminate Leprosy

Cellular components related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 8.96 TLR1 SLC11A1
2 sperm midpiece GO:0097225 8.62 PACRG DEFB1

Biological processes related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 TLR1 SLC11A1 DEFB1
2 inflammatory response GO:0006954 9.5 TLR1 SLC11A1 RIPK2
3 defense response to Gram-positive bacterium GO:0050830 9.48 RIPK2 DEFB1
4 positive regulation of interleukin-6 production GO:0032755 9.43 TLR1 RIPK2
5 positive regulation of tumor necrosis factor production GO:0032760 9.4 TLR1 RIPK2
6 defense response to Gram-negative bacterium GO:0050829 9.37 SLC11A1 DEFB1
7 positive regulation of interferon-gamma production GO:0032729 9.26 SLC11A1 RIPK2
8 antimicrobial humoral response GO:0019730 9.16 SLC11A1 DEFB1
9 macrophage activation GO:0042116 8.96 TLR1 SLC11A1
10 positive regulation of T-helper 1 type immune response GO:0002827 8.62 SLC11A1 RIPK2

Sources for Indeterminate Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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