MCID: IND004
MIFTS: 34

Indeterminate Leprosy

Categories: Endocrine diseases, Eye diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Indeterminate Leprosy

MalaCards integrated aliases for Indeterminate Leprosy:

Name: Indeterminate Leprosy 12 15 73
Uncharacteristic Leprosy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11851
ICD10 33 A30.0
ICD9CM 35 030.2
SNOMED-CT 68 14386001
UMLS 73 C0021192

Summaries for Indeterminate Leprosy

Disease Ontology : 12 A leprosy that is an early form of the disease which causes one to a few hypopigmented or erythematous macules.

MalaCards based summary : Indeterminate Leprosy, also known as uncharacteristic leprosy, is related to leprosy 3 and immunodeficiency due to a classical component pathway complement deficiency. An important gene associated with Indeterminate Leprosy is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include skin, eye and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Indeterminate Leprosy

Diseases related to Indeterminate Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 10.3
2 immunodeficiency due to a classical component pathway complement deficiency 10.3 C4A C4B
3 juvenile dermatitis herpetiformis 10.2 C4A C4B
4 epilepsy, familial temporal lobe, 2 10.2 C4A C4B
5 burn scar 10.1 TAC1 UCHL1
6 pediatric systemic lupus erythematosus 10.1 C4A C4B
7 giant cell myocarditis 10.1 CD68 HLA-B
8 pediatric angiosarcoma 10.1 F8 HBA1
9 reflex sympathetic dystrophy 10.1 NPS NPY
10 histiocytoid hemangioma 10.1 F8 HBA1
11 hobnail hemangioma 10.1 F8 HBA1
12 lymphoplasmacyte-rich meningioma 10.1 CD68 UCHL1
13 stereotypic movement disorder 10.1 NPY TAC1
14 drug reaction with eosinophilia and systemic symptoms 10.1 HLA-B TNF
15 diverticulitis of colon 10.1 NPS UCHL1
16 retinitis pigmentosa 68 10.1 NPS TAC1
17 lichen nitidus 10.1 CD68 UCHL1
18 epicondylitis 10.1 NPS TAC1
19 microscopic polyangiitis 10.1 HLA-B TNF
20 breast angiosarcoma 10.1 F8 HBA1
21 pulmonary artery leiomyosarcoma 10.1 CD68 HBA1
22 chronic graft versus host disease 10.1 MICA TNF
23 brain sarcoma 10.0 CD68 HBA1
24 anterior uveitis 10.0 HLA-B TNF
25 glomeruloid hemangioma 10.0 CD68 HBA1
26 miliaria 10.0 CD68 HBA1
27 hemangioma of liver 10.0 CD68 HBA1
28 hypersensitivity reaction type iii disease 10.0 C4A C4B TNF
29 autoimmune disease of musculoskeletal system 10.0 C4A C4B TNF
30 mixed liposarcoma 10.0 CD68 HBA1
31 compartment syndrome 10.0 F8 SLC17A5 TNF
32 nontuberculous mycobacterial lung disease 10.0 HLA-B TNF
33 takayasu arteritis 10.0 HLA-B MICA TNF
34 spondylitis 10.0 HLA-B MICA TNF
35 autonomic nervous system disease 10.0 NPS NPY TAC1
36 erythema elevatum diutinum 10.0 CD68 F13A1 HBA1
37 causalgia 10.0 NPS NPY TAC1
38 chondroid lipoma 10.0 CD68 HBA1
39 arthropathy 10.0 F8 MICA TNF
40 autoimmune gastritis 10.0 HLA-B TNF
41 upper respiratory tract disease 10.0 MLLT1 TAC1 TNF
42 psoriatic arthritis 10.0 HLA-B MICA TNF
43 peripheral nervous system disease 10.0 MLLT1 TAC1 TNF
44 congenital epulis 9.9 CD68 HBA1 UCHL1
45 spleen cancer 9.9 CD68 F8 HBA1
46 nonalcoholic steatohepatitis 9.9 SLC17A5 TNF
47 vascular hemostatic disease 9.9 HBA1 TNF
48 lymphocytic vasculitis 9.9
49 molluscum contagiosum 9.9
50 smallpox 9.9

Graphical network of the top 20 diseases related to Indeterminate Leprosy:



Diseases related to Indeterminate Leprosy

Symptoms & Phenotypes for Indeterminate Leprosy

GenomeRNAi Phenotypes related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.15 HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.15 HBA1 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.15 C4A C4B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.15 MICA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.15 HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.15 C4A C4B HBA1 SLC17A5
7 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.15 HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.15 MICA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.15 SLC17A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.15 SLC17A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.15 SLC17A5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.15 C4A C4B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.15 HBA1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.15 HLA-B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.15 C4A C4B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.15 HLA-B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.15 C4A C4B SLC17A5 HLA-B MICA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.15 HBA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.15 HLA-B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.15 C4A C4B
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.15 MICA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.15 SLC17A5
23 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.15 MICA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.15 C4A C4B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.15 HLA-B
26 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.15 HLA-B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.15 SLC17A5
28 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.15 C4A C4B
29 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.15 MICA

Drugs & Therapeutics for Indeterminate Leprosy

Search Clinical Trials , NIH Clinical Center for Indeterminate Leprosy

Genetic Tests for Indeterminate Leprosy

Anatomical Context for Indeterminate Leprosy

MalaCards organs/tissues related to Indeterminate Leprosy:

41
Skin, Eye, Lung, Brain, Liver, Colon, Spleen

Publications for Indeterminate Leprosy

Articles related to Indeterminate Leprosy:

(show all 43)
# Title Authors Year
1
Dermal Dendrocytes FXIIIa+ Are Essential Antigen-Presenting Cells in Indeterminate Leprosy. ( 25365500 )
2014
2
Indeterminate leprosy and lepromatous index case: four cases in the same family. ( 24346893 )
2013
3
Inoculation indeterminate leprosy localised to a smallpox vaccination scar. ( 18309715 )
2007
4
Indeterminate leprosy in an infant. ( 17343225 )
2006
5
Ulnar nerve abscess and relapse in a patient with indeterminate leprosy 1 year after completion of multidrug therapy. ( 15995337 )
2005
6
Indeterminate leprosy, molluscum contagiosum and nevus depigmentosus. ( 11898470 )
2001
7
Delay in diagnosis: indeterminate leprosy presenting with rheumatic manifestations. ( 10689224 )
2000
8
A case of lymphocytic vasculitis with infiltration of dermal nerves resembling indeterminate leprosy. ( 9614840 )
1998
9
Concomitant kala-azar, malaria, and progressive unstable indeterminate leprosy in an 8-year-old child. ( 9718914 )
1998
10
Histopathologic evidence to show that indeterminate leprosy may be a primary lesion of the disease. ( 9465152 )
1997
11
A case of morphoea with dermal neuritis as in indeterminate leprosy. ( 9474518 )
1997
12
Enhancement in the histological diagnosis of indeterminate leprosy by demonstration of mycobacterial antigens. ( 8711981 )
1995
13
Indeterminate leprosy: a seroimmunological and histochemical evaluation. ( 8942147 )
1994
14
Agreement between histopathological results in clinically diagnosed cases of indeterminate leprosy in SALo Paulo, Brazil. ( 7863756 )
1994
15
A case of secondary syphilis with a remarkable resemblance in histopathologic appearance to indeterminate leprosy. ( 7963917 )
1994
16
Primary involvement of scrotal skin in indeterminate leprosy. ( 8463713 )
1993
17
Indeterminate leprosy: a therapeutic evaluation. ( 1607714 )
1992
18
Treated-cured indeterminate leprosy: a search for predictive histopathological and immunohistochemical parameters in skin biopsies taken from patients at admission and at clinical discharge. ( 1293916 )
1992
19
Camptodactyly simulating claw hand in a patient with indeterminate leprosy. ( 1783793 )
1991
20
Indeterminate leprosy: histopathologic and histochemical predictive parameters involved in its possible change to paucibacillary or multibacillary leprosy. ( 2030308 )
1991
21
Epidemiological significance of indeterminate leprosy--a hospital based study. ( 1919090 )
1991
22
Clinico-histopathological study of multidrug therapy in indeterminate leprosy. ( 2358708 )
1990
23
Demonstration of PGL I antigens in skin biopsies in indeterminate leprosy patients: comparison with serological anti PGL I levels. ( 2503967 )
1989
24
Indeterminate leprosy in a population survey and in the subsequent follow-ups of children in Burma. ( 2533781 )
1989
25
Demonstration of acid-fast bacilli in skin biopsies from indeterminate leprosy cases. ( 3068861 )
1988
26
CD1 positive epidermal Langerhans cells in indeterminate leprosy. ( 3051852 )
1988
27
Comparative Study of Leprom114 Reaction in Indeterminate Leprosy and Controls. ( 28134172 )
1988
28
Indeterminate leprosy. A passing phase in the evolution of leprosy. ( 3312898 )
1987
29
Indeterminate leprosy: a clinical and histopathological evaluation. ( 3451924 )
1987
30
Indeterminate leprosy. ( 3905636 )
1985
31
Histopathological evidence of indeterminate leprosy in apparently uninvolved skin of entire spectrum of leprosy. ( 6361381 )
1983
32
Again on "indeterminate leprosy" (alias immature hanseniasis) ( 6685711 )
1983
33
Histology of indeterminate leprosy. ( 6749705 )
1982
34
Indeterminate leprosy--a valid clinical concept. ( 6889581 )
1982
35
Should indeterminate leprosy ever be diagnosed? ( 7195888 )
1981
36
Indeterminate leprosy. ( 4424552 )
1974
37
Late lepromin reaction in untreated patients with indeterminate leprosy under 21 years old in Burma. ( 4267842 )
1973
38
Immune response to Mycobacterium leprae in indeterminate leprosy patients. ( 4209177 )
1973
39
Contribution to the study of borderline and indeterminate leprosy. ( 5324502 )
1965
40
8TH INTERNATIONAL CONGRESS OF LEPROLOGY, RIO DE JANEIRO, 1963. REPORT OF THE ROUND TABLE ON BORDERLINE AND INDETERMINATE LEPROSY. ( 14116688 )
1964
41
Indeterminate leprosy. ( 13658160 )
1959
42
Indeterminate leprosy acquired during military service; report of a case and review. ( 13393863 )
1957
43
Indeterminate leprosy: a new clinical variety. ( 14821242 )
1951

Variations for Indeterminate Leprosy

Expression for Indeterminate Leprosy

Search GEO for disease gene expression data for Indeterminate Leprosy.

Pathways for Indeterminate Leprosy

Pathways related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 CD68 IL3RA TNF
2 11.47 C4A C4B TAC1 TNF
3 11.21 C4A C4B TNF
4 11.07 C4A C4B F13A1 F8
5 10.46 CD68 TNF

GO Terms for Indeterminate Leprosy

Cellular components related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.62 C4A C4B TAC1 UCHL1
2 extracellular space GO:0005615 9.61 C4A C4B DEFB1 F8 HBA1 MICA
3 blood microparticle GO:0072562 9.46 C4A C4B F13A1 HBA1
4 extracellular region GO:0005576 9.32 C4A C4B DEFB1 F13A1 F8 HBA1
5 plasma membrane GO:0005886 10 C4A C4B CD68 F8 HLA-B IL3RA

Biological processes related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.62 C4A C4B TAC1 TNF
2 neuropeptide signaling pathway GO:0007218 9.43 NPS NPY TAC1
3 positive regulation of synaptic transmission, GABAergic GO:0032230 9.16 NPS TAC1
4 positive regulation of apoptotic cell clearance GO:2000427 8.96 C4A C4B
5 positive regulation of action potential GO:0045760 8.62 NPS TAC1

Sources for Indeterminate Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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