MCID: INF006
MIFTS: 43

Infant Botulism

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Infant Botulism

MalaCards integrated aliases for Infant Botulism:

Name: Infant Botulism 12 58 15
Infant Intestinal Toxin-Mediated Botulism 58
Infant Intestinal Toxemia Botulism 58
Infant Intestinal Botulism 58
Botulism, Infantile 70
Infantile Botulism 58

Characteristics:

Orphanet epidemiological data:

58
infant botulism
Prevalence: 1-9/1000000 (Europe),1-9/100000 (United States),1-9/100000 (Argentina); Age of onset: Infancy,Neonatal; Age of death: early childhood;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases
Rare infectious diseases


Summaries for Infant Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has material basis in Clostridium botulinum A or has material basis in Clostridium botulinum B, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has symptom constipation, has symptom lethargy, has symptom difficulty feeding, has symptom swallowing, has symptom ptosis, has symptom loss of head control, and has symptom muscle weakness.

MalaCards based summary : Infant Botulism, also known as infant intestinal toxin-mediated botulism, is related to foodborne botulism and intestinal botulism, and has symptoms including ptosis, constipation and muscle weakness. An important gene associated with Infant Botulism is DENND11 (DENN Domain Containing 11), and among its related pathways/superpathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Clathrin-mediated endocytosis. The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and breast, and related phenotypes are sleep disturbance and ptosis

Related Diseases for Infant Botulism

Diseases related to Infant Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 foodborne botulism 29.5 VAPA VAMP4 VAMP2 VAMP1 SYT2 SV2C
2 intestinal botulism 28.9 SYT2 SV2C SV2A GPA33 BRD3
3 constipation 10.7
4 hypotonia 10.5
5 respiratory failure 10.4
6 sudden infant death syndrome 10.4
7 ptosis 10.2
8 aspiration pneumonia 10.1
9 spinal muscular atrophy 10.1
10 muscular atrophy 10.1
11 ileus 10.1
12 colitis 10.0
13 clostridium difficile colitis 10.0
14 urinary tract infection 10.0
15 neuromuscular disease 10.0
16 autonomic dysfunction 10.0
17 presynaptic congenital myasthenic syndromes 10.0 VAMP1 SYT2
18 neurogenic bladder 9.9
19 guillain-barre syndrome 9.9
20 poliomyelitis 9.9
21 intussusception 9.9
22 otitis media 9.9
23 strabismus 9.9
24 down syndrome 9.9
25 enterocolitis 9.9
26 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
27 myasthenia gravis 9.9
28 ocular motor apraxia 9.9
29 kearns-sayre syndrome 9.9
30 ifap syndrome 2 9.9
31 exanthem 9.9
32 megacolon 9.9
33 adult respiratory distress syndrome 9.9
34 alternating exotropia 9.9
35 exotropia 9.9
36 beriberi 9.9
37 polyneuropathy 9.9
38 neonatal myasthenia gravis 9.9
39 cholera 9.9
40 pharyngitis 9.9
41 bronchiolitis 9.9
42 inappropriate adh syndrome 9.9
43 cranial nerve palsy 9.9
44 myopathy 9.9
45 neuroblastoma 9.9
46 mechanical strabismus 9.9
47 muscular dystrophy 9.9
48 hypoglycemia 9.9
49 dysautonomia 9.9
50 dysphagia 9.9

Graphical network of the top 20 diseases related to Infant Botulism:



Diseases related to Infant Botulism

Symptoms & Phenotypes for Infant Botulism

Human phenotypes related to Infant Botulism:

58 31 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sleep disturbance 58 31 hallmark (90%) Very frequent (99-80%) HP:0002360
2 ptosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000508
3 diplopia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000651
4 dysarthria 58 31 hallmark (90%) Very frequent (99-80%) HP:0001260
5 dysphagia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002015
6 constipation 58 31 hallmark (90%) Very frequent (99-80%) HP:0002019
7 cranial nerve paralysis 58 31 hallmark (90%) Very frequent (99-80%) HP:0006824
8 mask-like facies 58 31 hallmark (90%) Very frequent (99-80%) HP:0000298
9 anorexia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002039
10 high pitched voice 58 31 hallmark (90%) Very frequent (99-80%) HP:0001620
11 cerebral palsy 58 31 hallmark (90%) Very frequent (99-80%) HP:0100021
12 keratoconjunctivitis sicca 58 31 hallmark (90%) Very frequent (99-80%) HP:0001097
13 xerostomia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000217
14 mydriasis 58 31 hallmark (90%) Very frequent (99-80%) HP:0011499
15 drooling 58 31 hallmark (90%) Very frequent (99-80%) HP:0002307
16 hypotonia 31 hallmark (90%) HP:0001252
17 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
18 hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0000822
19 bowel incontinence 58 31 frequent (33%) Frequent (79-30%) HP:0002607
20 respiratory insufficiency due to muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0002747
21 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
22 areflexia 58 31 frequent (33%) Frequent (79-30%) HP:0001284
23 abnormality of the pharynx 58 31 frequent (33%) Frequent (79-30%) HP:0000600
24 chronic otitis media 58 31 occasional (7.5%) Occasional (29-5%) HP:0000389
25 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
26 hyponatremia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002902
27 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695
28 muscular hypotonia 58 Very frequent (99-80%)
29 abnormality of movement 58 Very frequent (99-80%)

Symptoms:

12
  • ptosis
  • constipation
  • muscle weakness
  • lethargy
  • difficulty feeding
  • swallowing
  • loss of head control

Drugs & Therapeutics for Infant Botulism

Drugs for Infant Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Immunoglobulins
3 Rho(D) Immune Globulin
4 Antibodies
5 Immunoglobulins, Intravenous
6 gamma-Globulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 botulism immune globulin

Search NIH Clinical Center for Infant Botulism

Genetic Tests for Infant Botulism

Anatomical Context for Infant Botulism

MalaCards organs/tissues related to Infant Botulism:

40
Eye, Bone Marrow, Breast, Bone

Publications for Infant Botulism

Articles related to Infant Botulism:

(show top 50) (show all 447)
# Title Authors PMID Year
1
First confirmed case of infant botulism in Africa, caused by a dual-toxin-producing Clostridium botulinum strain. 61
33212262 2021
2
CRISPR-Cas9-Based Toolkit for Clostridium botulinum Group II Spore and Sporulation Research. 61
33584620 2021
3
Descriptive Epidemiology of Infant Botulism in California: The First 40 Years. 61
32800814 2020
4
Seven-Year Case-Control Study in California of Risk Factors for Infant Botulism. 61
32645406 2020
5
BOTOX injection to treat strabismus after infant botulism type B infection. 61
32923741 2020
6
Toxemia in Human Naturally Acquired Botulism. 61
33202855 2020
7
[Clinical analysis and laboratory diagnosis of three cases with infantile botulism caused by Clostridium botulinum type B]. 61
32521963 2020
8
Two Cases of Infant Botulism Presenting with Altered Mental Status. 61
32490395 2020
9
Human Botulism in France, 1875-2016. 61
32455538 2020
10
The First Reported Case of Infant Botulism in Korea: Treatable Infantile Neuromuscular Disease. 61
32281313 2020
11
Infant botulism in Singapore. 61
32488271 2020
12
Neuromuscular Junction Disorders and Floppy Infant Syndrome: A Comprehensive Review. 61
32071826 2020
13
Acute Neuromuscular Disorders in the Pediatric Intensive Care Unit. 61
31502491 2020
14
Adult Intestinal Toxemia Botulism. 61
31991691 2020
15
Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis. 61
31794471 2019
16
The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs. 61
31050145 2019
17
Molecular Characterization of Clostridium botulinum Harboring the bont/B7 Gene. 61
30932710 2019
18
Medical treatment for botulism. 61
30993666 2019
19
Infant Botulism With Asymmetric Cranial Nerve Palsies. 61
30639248 2019
20
Identification and characterization of Clostridium botulinum strains associated with an infant botulism case in China. 61
30401636 2019
21
Botulism - a rare but still present, life-threatening disease. 61
31181950 2019
22
Cost savings associated with timely treatment of botulism with botulism antitoxin heptavalent product. 61
31697731 2019
23
Antimicrobial Susceptibility of 260 Clostridium botulinum Type A, B, Ba, and Bf Strains and a Neurotoxigenic Clostridium baratii Type F Strain Isolated from California Infant Botulism Patients. 61
30275093 2018
24
Question 1: In infant botulism, is equine-derived botulinum antitoxin (EqBA) an effective alternative therapy to human-derived botulinum immune globulin (BIG)? 61
30007943 2018
25
Infant botulism: Two case reports and electroneuromyogram findings. 61
29887515 2018
26
Identification of Cross Reactive Antigens of C. botulinum Types A, B, E & F by Immunoproteomic Approach. 61
29332140 2018
27
BabyBIG has BIG advantages for treatment of infant botulism. 61
29389443 2018
28
More Clinical Mimics of Infant Botulism. 61
29229451 2018
29
Efficacy of Human Botulism Immune Globulin for the Treatment of Infant Botulism: The First 12 Years Post Licensure. 61
29229452 2018
30
Type F Infant Botulism: Investigation of Recent Clusters and Overview of This Exceedingly Rare Disease. 61
29293930 2017
31
Characterization of the functional activity of botulinum neurotoxin subtype B6. 61
28898517 2017
32
Infant botulism in Denmark from 1995 to 2015. 61
28874241 2017
33
[Botulism: Diagnosis and Therapy]. 61
28850968 2017
34
Botulinum neurotoxin type B uses a distinct entry pathway mediated by CDC42 into intestinal cells versus neuronal cells. 61
28296078 2017
35
[Infant botulism – why honey should be avoided for children up to one year]. 61
28742188 2017
36
Infant Botulism in the Very Young Neonate: A Case Series. 61
28765793 2017
37
Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China. 61
28705271 2017
38
Botulism in Italy, 1986 to 2015. 61
28661393 2017
39
Microbiology and foodborne pathogens in honey. 61
26176586 2017
40
Effective treatment of infant botulism on day 13 after symptom onset with human botulism antitoxin. 61
28306178 2017
41
Trends in Outcomes and Hospitalization Charges of Infant Botulism in the United States: A Comparative Analysis Between Kids' Inpatient Database and National Inpatient Sample. 61
28041655 2017
42
Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death. 61
28729852 2017
43
Flaccid paralysis in an infant associated with a dirty wound and application of honey. 61
28062435 2017
44
Neurotoxins from Clostridium botulinum (serotype A) isolated from the soil of Mendoza (Argentina) differ from the A-Hall archetype and from that causing infant botulism. 61
27527271 2016
45
Clostridium baratii: a rare case of pneumonia associated with an Alzheimer patient in Rio de Janeiro, Brazil. 61
28348769 2016
46
A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case. 61
27108966 2016
47
Diversity of Group I and II Clostridium botulinum Strains from France Including Recently Identified Subtypes. 61
27189984 2016
48
[Clinical analysis of three cases with infant botulism and review of literature]. 61
26957069 2016
49
Stimulated jitter analysis for the evaluation of neuromuscular junction disorders in children. 61
26663422 2016
50
A case of infant botulism in a 4-month-old baby. 61
25770157 2016

Variations for Infant Botulism

Expression for Infant Botulism

Search GEO for disease gene expression data for Infant Botulism.

Pathways for Infant Botulism

GO Terms for Infant Botulism

Cellular components related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.16 VAPA VAMP5 VAMP4 VAMP2 VAMP1 SYT2
2 integral component of membrane GO:0016021 10.16 YKT6 VAPA VAMP5 VAMP4 VAMP2 VAMP1
3 integral component of plasma membrane GO:0005887 9.93 YKT6 VAMP5 VAMP2 VAMP1 GPA33
4 cell junction GO:0030054 9.85 VAPA VAMP2 VAMP1 SYT2 SV2C SV2A
5 synapse GO:0045202 9.83 VAMP2 VAMP1 SYT2 SV2C SV2A
6 cytoplasmic vesicle GO:0031410 9.8 YKT6 VAMP2 VAMP1 SYT2 SV2C SV2A
7 neuron projection GO:0043005 9.78 VAMP2 VAMP1 SV2C SV2A
8 cytoplasmic vesicle membrane GO:0030659 9.67 YKT6 VAMP5 VAMP1
9 clathrin-coated vesicle membrane GO:0030665 9.58 VAMP4 VAMP2 SYT2
10 SNARE complex GO:0031201 9.56 YKT6 VAMP4 VAMP2 VAMP1
11 synaptic vesicle GO:0008021 9.55 VAMP4 VAMP2 SYT2 SV2C SV2A
12 azurophil granule membrane GO:0035577 9.52 VAPA VAMP1
13 integral component of synaptic vesicle membrane GO:0030285 9.26 VAMP4 VAMP1 SV2C SV2A
14 synaptic vesicle membrane GO:0030672 9.02 VAMP2 VAMP1 SYT2 SV2C SV2A

Biological processes related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.58 YKT6 VAPA VAMP4
2 membrane organization GO:0061024 9.5 VAMP4 VAMP2 SYT2
3 neurotransmitter secretion GO:0007269 9.49 VAMP2 SYT2
4 neurotransmitter transport GO:0006836 9.48 SV2C SV2A
5 synaptic vesicle endocytosis GO:0048488 9.46 VAMP2 SYT2
6 vesicle fusion GO:0006906 9.43 VAMP2 VAMP1
7 membrane fusion GO:0061025 9.43 YKT6 VAPA VAMP2
8 calcium ion regulated exocytosis GO:0017156 9.37 VAMP2 SYT2
9 Golgi to plasma membrane protein transport GO:0043001 9.33 VAMP5 VAMP4 VAMP2
10 SNARE complex assembly GO:0035493 9.13 VAMP4 VAMP2 VAMP1
11 vesicle-mediated transport GO:0016192 9.1 YKT6 VAMP5 VAMP4 VAMP2 VAMP1 SYT2

Molecular functions related to Infant Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SNARE binding GO:0000149 9.16 VAMP2 SYT2
2 syntaxin binding GO:0019905 9.13 VAMP2 VAMP1 SYT2
3 SNAP receptor activity GO:0005484 8.8 YKT6 VAMP2 VAMP1

Sources for Infant Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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