MCID: INF006
MIFTS: 50

Infant Botulism

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Infant Botulism

MalaCards integrated aliases for Infant Botulism:

Name: Infant Botulism 12 59 15
Infant Intestinal Toxin-Mediated Botulism 59
Infant Intestinal Toxemia Botulism 59
Infant Intestinal Botulism 59
Botulism, Infantile 73
Infantile Botulism 59

Characteristics:

Orphanet epidemiological data:

59
infant botulism
Prevalence: 1-9/1000000 (Europe),1-9/100000 (United States),1-9/100000 (Argentina); Age of onset: Infancy,Neonatal; Age of death: early childhood;

Classifications:



Summaries for Infant Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has material basis in Clostridium botulinum A or has material basis in Clostridium botulinum B, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has symptom constipation, has symptom lethargy, has symptom difficulty feeding, has symptom swallowing, has symptom ptosis, has symptom loss of head control, and has symptom muscle weakness.

MalaCards based summary : Infant Botulism, also known as infant intestinal toxin-mediated botulism, is related to foodborne botulism and presynaptic congenital myasthenic syndromes, and has symptoms including constipation, lethargy and difficulty feeding. An important gene associated with Infant Botulism is SYT2 (Synaptotagmin 2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Delta508-CFTR traffic / ER-to-Golgi in CF. The drugs Antibodies and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and bone, and related phenotypes are xerostomia and mask-like facies

Related Diseases for Infant Botulism

Diseases related to Infant Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 foodborne botulism 31.8 BRD3 EEA1 LY96 SNAP25 SYT1 SYT2
2 presynaptic congenital myasthenic syndromes 10.3 SNAP25 SYT2
3 intestinal botulism 10.3 FBXW2 LY96
4 wound botulism 10.2 FBXW2 LY96
5 sudden infant death syndrome 10.0
6 aging 9.9
7 colitis 9.9
8 clostridium difficile colitis 9.9
9 neurogenic bladder 9.8
10 down syndrome 9.7
11 enterocolitis 9.7
12 neuroblastoma 9.7
13 beriberi 9.7
14 cholera 9.7
15 bronchiolitis 9.7
16 hypotonia 9.7
17 tetanus 9.0 NSF SNAP25 VAMP2

Graphical network of the top 20 diseases related to Infant Botulism:



Diseases related to Infant Botulism

Symptoms & Phenotypes for Infant Botulism

Symptoms:

12
  • constipation
  • lethargy
  • difficulty feeding
  • swallowing
  • ptosis
  • loss of head control
  • muscle weakness

Human phenotypes related to Infant Botulism:

59 32 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 xerostomia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000217
2 mask-like facies 59 32 hallmark (90%) Very frequent (99-80%) HP:0000298
3 chronic otitis media 59 32 occasional (7.5%) Occasional (29-5%) HP:0000389
4 ptosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000508
5 abnormality of the pharynx 59 32 frequent (33%) Frequent (79-30%) HP:0000600
6 diplopia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000651
7 hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0000822
8 keratoconjunctivitis sicca 59 32 hallmark (90%) Very frequent (99-80%) HP:0001097
9 muscular hypotonia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001252
10 dysarthria 59 32 hallmark (90%) Very frequent (99-80%) HP:0001260
11 areflexia 59 32 frequent (33%) Frequent (79-30%) HP:0001284
12 high pitched voice 59 32 hallmark (90%) Very frequent (99-80%) HP:0001620
13 cardiac arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0001695
14 dysphagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002015
15 constipation 59 32 hallmark (90%) Very frequent (99-80%) HP:0002019
16 abdominal pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0002027
17 anorexia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002039
18 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
19 drooling 59 32 hallmark (90%) Very frequent (99-80%) HP:0002307
20 sleep disturbance 59 32 hallmark (90%) Very frequent (99-80%) HP:0002360
21 bowel incontinence 59 32 frequent (33%) Frequent (79-30%) HP:0002607
22 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
23 respiratory insufficiency due to muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0002747
24 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
25 cranial nerve paralysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0006824
26 mydriasis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011499
27 cerebral palsy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100021
28 abnormality of movement 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Infant Botulism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.73 AVP DPAGT1 GPA33 KCNJ11 NKX2-1 NSF
2 normal MP:0002873 9.23 RARA SNAP25 SYT1 SYT2 VAMP2 AVP

Drugs & Therapeutics for Infant Botulism

Drugs for Infant Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Not Applicable
2 gamma-Globulins Not Applicable
3 Immunoglobulins Not Applicable
4 Immunoglobulins, Intravenous Not Applicable
5 Rho(D) Immune Globulin Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 Not Applicable botulism immune globulin
2 Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents Completed NCT01721395 Not Applicable

Search NIH Clinical Center for Infant Botulism

Genetic Tests for Infant Botulism

Anatomical Context for Infant Botulism

MalaCards organs/tissues related to Infant Botulism:

41
Colon, Testes, Bone, Bone Marrow

Publications for Infant Botulism

Articles related to Infant Botulism:

(show top 50) (show all 244)
# Title Authors Year
1
More Clinical Mimics of Infant Botulism. ( 29229451 )
2018
2
Efficacy of Human Botulism Immune Globulin for the Treatment of Infant Botulism: The First 12 Years Post Licensure. ( 29229452 )
2018
3
Infant botulism: Two case reports and electroneuromyogram findings. ( 29887515 )
2018
4
BabyBIG has BIG advantages for treatment of infant botulism. ( 29389443 )
2018
5
Infant Botulism in the Very Young Neonate: A Case Series. ( 28765793 )
2017
6
Type F Infant Botulism: Investigation of Recent Clusters and Overview of This Exceedingly Rare Disease. ( 29293930 )
2017
7
Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China. ( 28705271 )
2017
8
Effective treatment of infant botulism on day 13 after symptom onset with human botulism antitoxin. ( 28306178 )
2017
9
Infant botulism in Denmark from 1995 to 2015. ( 28874241 )
2017
10
Trends in Outcomes and Hospitalization Charges of Infant Botulism in the United States: A Comparative Analysis Between Kids' Inpatient Database and National Inpatient Sample. ( 28041655 )
2016
11
A penicillin and metronidazole resistant Clostridium botulinum strain responsible for an infant botulism case. ( 27108966 )
2016
12
Neurotoxins from Clostridium botulinum (serotype A) isolated from the soil of Mendoza (Argentina) differ from the A-Hall archetype and from that causing infant botulism. ( 27527271 )
2016
13
First report of an infant botulism case due to Clostridium botulinum type Af. ( 25502535 )
2015
14
Genomic Epidemiology of Clostridium botulinum Isolates from Temporally Related Cases of Infant Botulism in New South Wales, Australia. ( 26109442 )
2015
15
Infant Botulism: Review and Clinical Update. ( 25882077 )
2015
16
Stimulated jitter analysis in the early diagnosis of infant botulism. ( 25787697 )
2015
17
A case of infant botulism in a 4-month-old baby. ( 25770157 )
2015
18
Abnormal Neuroimaging in a Case of Infant Botulism. ( 26697417 )
2015
19
Notes from the Field: Infant Botulism Caused by Clostridium baratii Type F - Iowa, 2013. ( 25879901 )
2015
20
Stimulated jitter in infant botulism. ( 26096260 )
2015
21
Infant botulism and indications for administration of botulism immune globulin. ( 24488164 )
2014
22
Infant botulism due to C. butyricum type E toxin: a novel environmental association with pet terrapins. ( 25306863 )
2014
23
Molecular epidemiology of infant botulism in california and elsewhere, 1976-2010. ( 24924163 )
2014
24
Infant botulism in Costa Rica: first report from Central America. ( 24423723 )
2014
25
Infant botulism in Andalusia (Southern Spain). ( 24468429 )
2014
26
Infant botulism: is there an association with thiamine deficiency? ( 25311602 )
2014
27
Infant botulism with prolonged faecal excretion of botulinum neurotoxin and Clostridium botulinum for 7 months. ( 23688392 )
2014
28
A case of infant botulism infection due to consumption of untreated well-water. ( 24461790 )
2014
29
Of war and sausages: a case-directed review of infant botulism. ( 23438300 )
2013
30
Infant botulism: advice on avoiding feeding honey to babies and other possible risk factors. ( 23914481 )
2013
31
A 3-month-old boy with concomitant respiratory syncytial virus bronchiolitis and infant botulism. ( 23328826 )
2013
32
Infant botulism: first two confirmed cases in Slovenia and literature review. ( 23707631 )
2013
33
Two cases of type A infant botulism in Grenoble, France: no honey for infants. ( 22159905 )
2012
34
Infant botulism and botulism immune globulin in the UK: a case series of four infants. ( 22294666 )
2012
35
Infant botulism following honey ingestion. ( 22962382 )
2012
36
Equine botulinum antitoxin for the treatment of infant botulism. ( 21918119 )
2011
37
Concerning the article "An infant botulism case occurred in Italy". ( 20424530 )
2010
38
First report worldwide of an infant botulism case due to Clostridium botulinum type E. ( 19906896 )
2010
39
Infant botulism in Australia: availability of human botulinum antitoxin for treatment. ( 21077820 )
2010
40
Infant botulism intoxication and autonomic nervous system dysfunction. ( 19327405 )
2009
41
Phenotypic characterization of Clostridium botulinum strains isolated from infant botulism cases in Argentina. ( 19831311 )
2009
42
Infant botulism. ( 19636165 )
2009
43
Infant botulism mimicking Hirschprung's disease. ( 19853738 )
2009
44
Report of two unlinked cases of infant botulism in the UK in October 2007. ( 19661202 )
2009
45
Infant Botulism and Raised Intraocular Pressure. ( 19873952 )
2009
46
Genetic characterization of Clostridium botulinum associated with type B infant botulism in Japan. ( 19571018 )
2009
47
Infant botulism mimicking an acute abdomen. ( 20046108 )
2009
48
Linden flower (Tilia spp.) as potential vehicle of Clostridium botulinum spores in the transmission of infant botulism. ( 20085187 )
2009
49
Global occurrence of infant botulism, 1976-2006. ( 18595978 )
2008
50
Denmark: botulism in an infant or infant botulism? ( 19094919 )
2008

Variations for Infant Botulism

Expression for Infant Botulism

Search GEO for disease gene expression data for Infant Botulism.

Pathways for Infant Botulism

Pathways related to Infant Botulism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 KCNJ11 NSF SNAP25 SYT1 SYT2 VAMP2
2
Show member pathways
12.18 EEA1 NSF SNAP25 VAMP2
3 12.17 AVP NKX2-1 NSF SNAP25 SYT1 VAMP2
4
Show member pathways
12.11 AVP SYT1 SYT2 VAMP2
5
Show member pathways
11.68 NSF SNAP25 SYT1 VAMP2
6
Show member pathways
11.46 SNAP25 SYT1 SYT2 VAMP2
7 11.19 AVP NSF VAMP2
8
Show member pathways
10.52 EEA1 NSF SNAP25 VAMP2
9 10.09 SNAP25 SYT1 VAMP2

GO Terms for Infant Botulism

Cellular components related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.92 EEA1 SNAP25 SYT1 SYT2 VAMP2
2 neuron projection GO:0043005 9.88 CDC42 RARA SNAP25 SYT1 VAMP2
3 cytoplasmic vesicle GO:0031410 9.85 CDC42 EEA1 NTS SYT1 SYT2 VAMP2
4 vesicle GO:0031982 9.76 CDC42 SNAP25 VAMP2 VAPA
5 myelin sheath GO:0043209 9.73 KCNJ11 NSF SNAP25
6 secretory granule GO:0030141 9.71 AVP SYT1 VAMP2
7 synaptic vesicle membrane GO:0030672 9.69 SYT1 SYT2 VAMP2
8 SNARE complex GO:0031201 9.61 SNAP25 SYT1 VAMP2
9 neuron projection terminus GO:0044306 9.55 SYT1 VAMP2
10 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 9.49 SYT1 VAMP2
11 chromaffin granule membrane GO:0042584 9.4 SYT1 SYT2
12 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 9.32 SYT1 VAMP2
13 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 9.26 SNAP25 VAMP2
14 synaptic vesicle GO:0008021 9.26 SNAP25 SYT1 SYT2 VAMP2
15 clathrin-sculpted glutamate transport vesicle membrane GO:0060203 9.16 SYT1 VAMP2
16 clathrin-coated vesicle membrane GO:0030665 8.92 AVP SYT1 SYT2 VAMP2

Biological processes related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 exocytosis GO:0006887 9.67 NSF SNAP25 VAMP2
2 membrane organization GO:0061024 9.62 AVP SYT1 SYT2 VAMP2
3 locomotory behavior GO:0007626 9.61 AVP NKX2-1 SNAP25
4 regulation of exocytosis GO:0017157 9.54 NSF SYT1 VAMP2
5 regulation of blood vessel size GO:0050880 9.48 AVP NTS
6 positive regulation of dendrite extension GO:1903861 9.46 SYT1 SYT2
7 neurotransmitter secretion GO:0007269 9.46 SNAP25 SYT1 SYT2 VAMP2
8 glutamate secretion GO:0014047 9.43 SNAP25 SYT1 VAMP2
9 viral RNA genome replication GO:0039694 9.4 CDC42 EEA1
10 synaptic vesicle exocytosis GO:0016079 9.26 SNAP25 SYT1 SYT2 VAMP2
11 vesicle fusion GO:0006906 9.02 EEA1 SNAP25 SYT1 SYT2 VAMP2

Molecular functions related to Infant Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent protein binding GO:0048306 9.43 SNAP25 SYT1 VAMP2
2 1-phosphatidylinositol binding GO:0005545 9.4 EEA1 SYT1
3 RNA polymerase II regulatory region DNA binding GO:0001012 9.37 NKX2-1 RARA
4 syntaxin binding GO:0019905 9.35 NSF SNAP25 SYT1 SYT2 VAMP2
5 SNARE binding GO:0000149 9.33 NSF SYT1 VAMP2
6 syntaxin-1 binding GO:0017075 8.92 NSF SNAP25 SYT1 VAMP2
7 protein binding GO:0005515 10.25 BRD3 CDC42 EEA1 FBXW2 GPA33 KCNJ11

Sources for Infant Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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