MCID: INF006
MIFTS: 52

Infant Botulism

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Infant Botulism

MalaCards integrated aliases for Infant Botulism:

Name: Infant Botulism 12 59 15
Infant Intestinal Toxin-Mediated Botulism 59
Infant Intestinal Toxemia Botulism 59
Infant Intestinal Botulism 59
Botulism, Infantile 73
Infantile Botulism 59

Characteristics:

Orphanet epidemiological data:

59
infant botulism
Prevalence: 1-9/1000000 (Europe),1-9/100000 (United States),1-9/100000 (Argentina); Age of onset: Infancy,Neonatal; Age of death: early childhood;

Classifications:



Summaries for Infant Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has material basis in Clostridium botulinum A or has material basis in Clostridium botulinum B, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has symptom constipation, has symptom lethargy, has symptom difficulty feeding, has symptom swallowing, has symptom ptosis, has symptom loss of head control, and has symptom muscle weakness.

MalaCards based summary : Infant Botulism, also known as infant intestinal toxin-mediated botulism, is related to foodborne botulism and sudden infant death syndrome. An important gene associated with Infant Botulism is SYT2 (Synaptotagmin 2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Delta508-CFTR traffic / ER-to-Golgi in CF. The drugs Antibodies and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and colon, and related phenotypes are ptosis and diplopia

Related Diseases for Infant Botulism

Diseases related to Infant Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 foodborne botulism 32.9 BRD3 EEA1 LY96 SNAP25 SYT1 SYT2
2 sudden infant death syndrome 10.2
3 presynaptic congenital myasthenic syndromes 10.2 SNAP25 SYT2
4 intestinal botulism 10.1 FBXW2 LY96
5 wound botulism 10.1 FBXW2 LY96
6 cone-rod dystrophy 7 10.1 SNAP25 SYT1
7 colitis 10.0
8 clostridium difficile colitis 10.0
9 neurogenic bladder 10.0
10 secondary hypertrophic osteoarthropathy 9.9 AVP KCNJ11
11 down syndrome 9.9
12 enterocolitis 9.9
13 neuroblastoma 9.9
14 beriberi 9.9
15 cholera 9.9
16 bronchiolitis 9.9
17 hypotonia 9.9
18 tetanus 9.8 NSF SNAP25 VAMP2

Graphical network of the top 20 diseases related to Infant Botulism:



Diseases related to Infant Botulism

Symptoms & Phenotypes for Infant Botulism

Human phenotypes related to Infant Botulism:

59 32 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000651
3 hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0000822
4 muscular hypotonia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001252
5 dysarthria 59 32 hallmark (90%) Very frequent (99-80%) HP:0001260
6 dysphagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002015
7 constipation 59 32 hallmark (90%) Very frequent (99-80%) HP:0002019
8 sleep disturbance 59 32 hallmark (90%) Very frequent (99-80%) HP:0002360
9 bowel incontinence 59 32 frequent (33%) Frequent (79-30%) HP:0002607
10 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
11 chronic otitis media 59 32 occasional (7.5%) Occasional (29-5%) HP:0000389
12 cranial nerve paralysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0006824
13 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
14 respiratory insufficiency due to muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0002747
15 abdominal pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0002027
16 mask-like facies 59 32 hallmark (90%) Very frequent (99-80%) HP:0000298
17 anorexia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002039
18 keratoconjunctivitis sicca 59 32 hallmark (90%) Very frequent (99-80%) HP:0001097
19 xerostomia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000217
20 abnormality of the pharynx 59 32 frequent (33%) Frequent (79-30%) HP:0000600
21 areflexia 59 32 frequent (33%) Frequent (79-30%) HP:0001284
22 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
23 cerebral palsy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100021
24 high pitched voice 59 32 hallmark (90%) Very frequent (99-80%) HP:0001620
25 cardiac arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0001695
26 drooling 59 32 hallmark (90%) Very frequent (99-80%) HP:0002307
27 mydriasis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011499
28 abnormality of movement 59 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Infant Botulism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-4 10.1 BRD3 SYT2
2 Decreased viability GR00240-S-1 10.1 RARA TXN
3 Decreased viability GR00381-A-1 10.1 CDC42 FBXW2 RARA SYT1 SYT2
4 Decreased viability GR00402-S-2 10.1 AVP BRD3 CDC42 DPAGT1 EEA1 FBXW2
5 no effect GR00402-S-1 9.6 AVP BRD3 CDC42 DPAGT1 EEA1 FBXW2

MGI Mouse Phenotypes related to Infant Botulism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.73 AVP DPAGT1 GPA33 KCNJ11 NKX2-1 NSF
2 normal MP:0002873 9.23 AVP DPAGT1 NKX2-1 RARA SNAP25 SYT1

Drugs & Therapeutics for Infant Botulism

Drugs for Infant Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Not Applicable
2 gamma-Globulins Not Applicable
3 Rho(D) Immune Globulin Not Applicable
4 Immunoglobulins, Intravenous Not Applicable
5 Immunoglobulins Not Applicable
6 Immunologic Factors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 Not Applicable botulism immune globulin
2 Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents Completed NCT01721395 Not Applicable

Search NIH Clinical Center for Infant Botulism

Genetic Tests for Infant Botulism

Anatomical Context for Infant Botulism

MalaCards organs/tissues related to Infant Botulism:

41
Bone, Eye, Colon, Testes, Bone Marrow, Breast

Publications for Infant Botulism

Articles related to Infant Botulism:

(show top 50) (show all 249)
# Title Authors Year
1
More Clinical Mimics of Infant Botulism. ( 29229451 )
2018
2
Efficacy of Human Botulism Immune Globulin for the Treatment of Infant Botulism: The First 12 Years Post Licensure. ( 29229452 )
2018
3
Infant botulism: Two case reports and electroneuromyogram findings. ( 29887515 )
2018
4
BabyBIG has BIG advantages for treatment of infant botulism. ( 29389443 )
2018
5
Question 1: In infant botulism, is equine-derived botulinum antitoxin (EqBA) an effective alternative therapy to human-derived botulinum immune globulin (BIG)? ( 30007943 )
2018
6
Antimicrobial Susceptibility of 260 Clostridium botulinum Type A, B, Ba, and Bf Strains and a Neurotoxigenic Clostridium baratii Type F Strain Isolated from California Infant Botulism Patients. ( 30275093 )
2018
7
Identification and characterization of Clostridium botulinum strains associated with an infant botulism case in China. ( 30401636 )
2018
8
Infant Botulism in the Very Young Neonate: A Case Series. ( 28765793 )
2017
9
Type F Infant Botulism: Investigation of Recent Clusters and Overview of This Exceedingly Rare Disease. ( 29293930 )
2017
10
Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China. ( 28705271 )
2017
11
Effective treatment of infant botulism on day 13 after symptom onset with human botulism antitoxin. ( 28306178 )
2017
12
Infant botulism in Denmark from 1995 to 2015. ( 28874241 )
2017
13
Trends in Outcomes and Hospitalization Charges of Infant Botulism in the United States: A Comparative Analysis Between Kids' Inpatient Database and National Inpatient Sample. ( 28041655 )
2016
14
A penicillin and metronidazole resistant Clostridium botulinum strain responsible for an infant botulism case. ( 27108966 )
2016
15
Neurotoxins from Clostridium botulinum (serotype A) isolated from the soil of Mendoza (Argentina) differ from the A-Hall archetype and from that causing infant botulism. ( 27527271 )
2016
16
First report of an infant botulism case due to Clostridium botulinum type Af. ( 25502535 )
2015
17
Genomic Epidemiology of Clostridium botulinum Isolates from Temporally Related Cases of Infant Botulism in New South Wales, Australia. ( 26109442 )
2015
18
Infant Botulism: Review and Clinical Update. ( 25882077 )
2015
19
Stimulated jitter analysis in the early diagnosis of infant botulism. ( 25787697 )
2015
20
A case of infant botulism in a 4-month-old baby. ( 25770157 )
2015
21
Abnormal Neuroimaging in a Case of Infant Botulism. ( 26697417 )
2015
22
Notes from the Field: Infant Botulism Caused by Clostridium baratii Type F - Iowa, 2013. ( 25879901 )
2015
23
Stimulated jitter in infant botulism. ( 26096260 )
2015
24
Infant botulism and indications for administration of botulism immune globulin. ( 24488164 )
2014
25
Infant botulism due to C. butyricum type E toxin: a novel environmental association with pet terrapins. ( 25306863 )
2014
26
Molecular epidemiology of infant botulism in california and elsewhere, 1976-2010. ( 24924163 )
2014
27
Infant botulism in Costa Rica: first report from Central America. ( 24423723 )
2014
28
Infant botulism in Andalusia (Southern Spain). ( 24468429 )
2014
29
Infant botulism: is there an association with thiamine deficiency? ( 25311602 )
2014
30
Infant botulism with prolonged faecal excretion of botulinum neurotoxin and Clostridium botulinum for 7 months. ( 23688392 )
2014
31
A case of infant botulism infection due to consumption of untreated well-water. ( 24461790 )
2014
32
Of war and sausages: a case-directed review of infant botulism. ( 23438300 )
2013
33
Infant botulism: advice on avoiding feeding honey to babies and other possible risk factors. ( 23914481 )
2013
34
A 3-month-old boy with concomitant respiratory syncytial virus bronchiolitis and infant botulism. ( 23328826 )
2013
35
Infant botulism: first two confirmed cases in Slovenia and literature review. ( 23707631 )
2013
36
Two cases of type A infant botulism in Grenoble, France: no honey for infants. ( 22159905 )
2012
37
Infant botulism and botulism immune globulin in the UK: a case series of four infants. ( 22294666 )
2012
38
Infant botulism following honey ingestion. ( 22962382 )
2012
39
Equine botulinum antitoxin for the treatment of infant botulism. ( 21918119 )
2011
40
Concerning the article "An infant botulism case occurred in Italy". ( 20424530 )
2010
41
First report worldwide of an infant botulism case due to Clostridium botulinum type E. ( 19906896 )
2010
42
Infant botulism in Australia: availability of human botulinum antitoxin for treatment. ( 21077820 )
2010
43
Infant botulism. ( 25610131 )
2010
44
Infant botulism intoxication and autonomic nervous system dysfunction. ( 19327405 )
2009
45
Phenotypic characterization of Clostridium botulinum strains isolated from infant botulism cases in Argentina. ( 19831311 )
2009
46
Infant botulism. ( 19636165 )
2009
47
Infant botulism mimicking Hirschprung's disease. ( 19853738 )
2009
48
Report of two unlinked cases of infant botulism in the UK in October 2007. ( 19661202 )
2009
49
Infant Botulism and Raised Intraocular Pressure. ( 19873952 )
2009
50
Genetic characterization of Clostridium botulinum associated with type B infant botulism in Japan. ( 19571018 )
2009

Variations for Infant Botulism

Expression for Infant Botulism

Search GEO for disease gene expression data for Infant Botulism.

Pathways for Infant Botulism

Pathways related to Infant Botulism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 KCNJ11 NSF SNAP25 SYT1 SYT2 VAMP2
2
Show member pathways
12.18 EEA1 NSF SNAP25 VAMP2
3 12.17 AVP NKX2-1 NSF SNAP25 SYT1 VAMP2
4
Show member pathways
12.11 AVP SYT1 SYT2 VAMP2
5
Show member pathways
11.68 NSF SNAP25 SYT1 VAMP2
6
Show member pathways
11.46 SNAP25 SYT1 SYT2 VAMP2
7 11.19 AVP NSF VAMP2
8
Show member pathways
10.52 EEA1 NSF SNAP25 VAMP2
9 10.09 SNAP25 SYT1 VAMP2

GO Terms for Infant Botulism

Cellular components related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.93 EEA1 NTS SYT1 SYT2 VAMP2
2 synapse GO:0045202 9.91 EEA1 SNAP25 SYT1 SYT2 VAMP2
3 neuron projection GO:0043005 9.85 CDC42 RARA SNAP25 SYT1 VAMP2
4 myelin sheath GO:0043209 9.73 KCNJ11 NSF SNAP25
5 synaptic vesicle membrane GO:0030672 9.67 SYT1 SYT2 VAMP2
6 SNARE complex GO:0031201 9.58 SNAP25 SYT1 VAMP2
7 exocytic vesicle GO:0070382 9.57 SYT1 SYT2
8 neuron projection terminus GO:0044306 9.55 SYT1 VAMP2
9 dense core granule GO:0031045 9.52 SYT1 SYT2
10 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 9.48 SYT1 VAMP2
11 synaptic vesicle GO:0008021 9.46 SNAP25 SYT1 SYT2 VAMP2
12 chromaffin granule membrane GO:0042584 9.43 SYT1 SYT2
13 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 9.37 SYT1 VAMP2
14 clathrin-sculpted glutamate transport vesicle membrane GO:0060203 9.32 SYT1 VAMP2
15 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 9.26 SNAP25 VAMP2
16 secretory granule GO:0030141 9.26 AVP CDC42 SYT1 VAMP2
17 clathrin-coated vesicle membrane GO:0030665 8.92 AVP SYT1 SYT2 VAMP2

Biological processes related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 vesicle-mediated transport GO:0016192 9.73 NSF SYT1 SYT2 VAMP2
2 exocytosis GO:0006887 9.69 NSF SNAP25 VAMP2
3 locomotory behavior GO:0007626 9.58 AVP NKX2-1 SNAP25
4 membrane organization GO:0061024 9.56 AVP SYT1 SYT2 VAMP2
5 positive regulation of intracellular protein transport GO:0090316 9.54 CDC42 VAMP2
6 positive regulation of dendrite extension GO:1903861 9.52 SYT1 SYT2
7 neurotransmitter secretion GO:0007269 9.5 SNAP25 SYT1 SYT2
8 regulation of blood vessel size GO:0050880 9.49 AVP NTS
9 glutamate secretion GO:0014047 9.48 SYT1 VAMP2
10 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.46 SYT1 SYT2
11 viral RNA genome replication GO:0039694 9.37 CDC42 EEA1
12 regulation of exocytosis GO:0017157 9.33 NSF SYT1 VAMP2
13 calcium ion regulated exocytosis GO:0017156 9.13 SYT1 SYT2 VAMP2
14 synaptic vesicle exocytosis GO:0016079 8.92 SNAP25 SYT1 SYT2 VAMP2

Molecular functions related to Infant Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent protein binding GO:0048306 9.5 SNAP25 SYT1 VAMP2
2 SNARE binding GO:0000149 9.46 NSF SYT1 SYT2 VAMP2
3 1-phosphatidylinositol binding GO:0005545 9.4 EEA1 SYT1
4 RNA polymerase II regulatory region DNA binding GO:0001012 9.37 NKX2-1 RARA
5 syntaxin-1 binding GO:0017075 9.26 NSF SNAP25 SYT1 VAMP2
6 syntaxin binding GO:0019905 9.02 NSF SNAP25 SYT1 SYT2 VAMP2
7 protein binding GO:0005515 10.19 BRD3 CDC42 EEA1 FBXW2 GPA33 KCNJ11

Sources for Infant Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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