MCID: INF006
MIFTS: 50

Infant Botulism

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Infant Botulism

MalaCards integrated aliases for Infant Botulism:

Name: Infant Botulism 12 60 15
Infant Intestinal Toxin-Mediated Botulism 60
Infant Intestinal Toxemia Botulism 60
Infant Intestinal Botulism 60
Botulism, Infantile 74
Infantile Botulism 60

Characteristics:

Orphanet epidemiological data:

60
infant botulism
Prevalence: 1-9/1000000 (Europe),1-9/100000 (United States),1-9/100000 (Argentina); Age of onset: Infancy,Neonatal; Age of death: early childhood;

Classifications:



Summaries for Infant Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has material basis in Clostridium botulinum A or has material basis in Clostridium botulinum B, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has symptom constipation, has symptom lethargy, has symptom difficulty feeding, has symptom swallowing, has symptom ptosis, has symptom loss of head control, and has symptom muscle weakness.

MalaCards based summary : Infant Botulism, also known as infant intestinal toxin-mediated botulism, is related to foodborne botulism and presynaptic congenital myasthenic syndromes. An important gene associated with Infant Botulism is SYT2 (Synaptotagmin 2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Neuroscience. The drugs Immunoglobulins and Rho(D) Immune Globulin have been mentioned in the context of this disorder. Affiliated tissues include eye, colon and breast, and related phenotypes are ptosis and diplopia

Related Diseases for Infant Botulism

Diseases related to Infant Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 foodborne botulism 32.6 BRD3 EEA1 LY96 SNAP25 SYT1 SYT2
2 presynaptic congenital myasthenic syndromes 10.2 SNAP25 SYT2
3 sudden infant death syndrome 10.2
4 intestinal botulism 10.1 FBXW2 LY96
5 wound botulism 10.1 FBXW2 LY96
6 cone-rod dystrophy 7 10.1 SNAP25 SYT1
7 colitis 10.0
8 clostridium difficile colitis 10.0
9 neurogenic bladder 10.0
10 down syndrome 9.9
11 enterocolitis 9.9
12 neuroblastoma 9.9
13 beriberi 9.9
14 cholera 9.9
15 bronchiolitis 9.9
16 hypotonia 9.9
17 space motion sickness 9.9 AVP NTS
18 tetanus 9.5 NSF SNAP25 VAMP2

Graphical network of the top 20 diseases related to Infant Botulism:



Diseases related to Infant Botulism

Symptoms & Phenotypes for Infant Botulism

Human phenotypes related to Infant Botulism:

60 33 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000651
3 muscular hypotonia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001252
4 dysarthria 60 33 hallmark (90%) Very frequent (99-80%) HP:0001260
5 dysphagia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002015
6 constipation 60 33 hallmark (90%) Very frequent (99-80%) HP:0002019
7 sleep disturbance 60 33 hallmark (90%) Very frequent (99-80%) HP:0002360
8 cranial nerve paralysis 60 33 hallmark (90%) Very frequent (99-80%) HP:0006824
9 mask-like facies 60 33 hallmark (90%) Very frequent (99-80%) HP:0000298
10 anorexia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002039
11 keratoconjunctivitis sicca 60 33 hallmark (90%) Very frequent (99-80%) HP:0001097
12 xerostomia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000217
13 cerebral palsy 60 33 hallmark (90%) Very frequent (99-80%) HP:0100021
14 high pitched voice 60 33 hallmark (90%) Very frequent (99-80%) HP:0001620
15 drooling 60 33 hallmark (90%) Very frequent (99-80%) HP:0002307
16 mydriasis 60 33 hallmark (90%) Very frequent (99-80%) HP:0011499
17 hypertension 60 33 frequent (33%) Frequent (79-30%) HP:0000822
18 bowel incontinence 60 33 frequent (33%) Frequent (79-30%) HP:0002607
19 hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0002615
20 dyspnea 60 33 frequent (33%) Frequent (79-30%) HP:0002094
21 respiratory insufficiency due to muscle weakness 60 33 frequent (33%) Frequent (79-30%) HP:0002747
22 abnormality of the pharynx 60 33 frequent (33%) Frequent (79-30%) HP:0000600
23 areflexia 60 33 frequent (33%) Frequent (79-30%) HP:0001284
24 chronic otitis media 60 33 occasional (7.5%) Occasional (29-5%) HP:0000389
25 abdominal pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0002027
26 hyponatremia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002902
27 cardiac arrest 60 33 occasional (7.5%) Occasional (29-5%) HP:0001695
28 abnormality of movement 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Infant Botulism:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.17 AVP NKX2-1 RARA SNAP25 SYT1 SYT2

Drugs & Therapeutics for Infant Botulism

Drugs for Infant Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Not Applicable
2 Rho(D) Immune Globulin Not Applicable
3 gamma-Globulins Not Applicable
4 Immunoglobulins, Intravenous Not Applicable
5 Antibodies Not Applicable
6 Immunologic Factors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 Not Applicable botulism immune globulin
2 Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents Completed NCT01721395 Not Applicable

Search NIH Clinical Center for Infant Botulism

Genetic Tests for Infant Botulism

Anatomical Context for Infant Botulism

MalaCards organs/tissues related to Infant Botulism:

42
Eye, Colon, Breast, Bone, Testes, Bone Marrow

Publications for Infant Botulism

Articles related to Infant Botulism:

(show top 50) (show all 250)
# Title Authors Year
1
Infant Botulism With Asymmetric Cranial Nerve Palsies. ( 30639248 )
2019
2
More Clinical Mimics of Infant Botulism. ( 29229451 )
2018
3
Efficacy of Human Botulism Immune Globulin for the Treatment of Infant Botulism: The First 12 Years Post Licensure. ( 29229452 )
2018
4
Infant botulism: Two case reports and electroneuromyogram findings. ( 29887515 )
2018
5
BabyBIG has BIG advantages for treatment of infant botulism. ( 29389443 )
2018
6
Question 1: In infant botulism, is equine-derived botulinum antitoxin (EqBA) an effective alternative therapy to human-derived botulinum immune globulin (BIG)? ( 30007943 )
2018
7
Antimicrobial Susceptibility of 260 Clostridium botulinum Type A, B, Ba, and Bf Strains and a Neurotoxigenic Clostridium baratii Type F Strain Isolated from California Infant Botulism Patients. ( 30275093 )
2018
8
Identification and characterization of Clostridium botulinum strains associated with an infant botulism case in China. ( 30401636 )
2018
9
Infant Botulism in the Very Young Neonate: A Case Series. ( 28765793 )
2017
10
Type F Infant Botulism: Investigation of Recent Clusters and Overview of This Exceedingly Rare Disease. ( 29293930 )
2017
11
Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China. ( 28705271 )
2017
12
Effective treatment of infant botulism on day 13 after symptom onset with human botulism antitoxin. ( 28306178 )
2017
13
Infant botulism in Denmark from 1995 to 2015. ( 28874241 )
2017
14
Trends in Outcomes and Hospitalization Charges of Infant Botulism in the United States: A Comparative Analysis Between Kids' Inpatient Database and National Inpatient Sample. ( 28041655 )
2016
15
A penicillin and metronidazole resistant Clostridium botulinum strain responsible for an infant botulism case. ( 27108966 )
2016
16
Neurotoxins from Clostridium botulinum (serotype A) isolated from the soil of Mendoza (Argentina) differ from the A-Hall archetype and from that causing infant botulism. ( 27527271 )
2016
17
First report of an infant botulism case due to Clostridium botulinum type Af. ( 25502535 )
2015
18
Genomic Epidemiology of Clostridium botulinum Isolates from Temporally Related Cases of Infant Botulism in New South Wales, Australia. ( 26109442 )
2015
19
Infant Botulism: Review and Clinical Update. ( 25882077 )
2015
20
Stimulated jitter analysis in the early diagnosis of infant botulism. ( 25787697 )
2015
21
A case of infant botulism in a 4-month-old baby. ( 25770157 )
2015
22
Abnormal Neuroimaging in a Case of Infant Botulism. ( 26697417 )
2015
23
Notes from the Field: Infant Botulism Caused by Clostridium baratii Type F - Iowa, 2013. ( 25879901 )
2015
24
Stimulated jitter in infant botulism. ( 26096260 )
2015
25
Infant botulism and indications for administration of botulism immune globulin. ( 24488164 )
2014
26
Infant botulism due to C. butyricum type E toxin: a novel environmental association with pet terrapins. ( 25306863 )
2014
27
Molecular epidemiology of infant botulism in california and elsewhere, 1976-2010. ( 24924163 )
2014
28
Infant botulism in Costa Rica: first report from Central America. ( 24423723 )
2014
29
Infant botulism in Andalusia (Southern Spain). ( 24468429 )
2014
30
Infant botulism: is there an association with thiamine deficiency? ( 25311602 )
2014
31
Infant botulism with prolonged faecal excretion of botulinum neurotoxin and Clostridium botulinum for 7 months. ( 23688392 )
2014
32
A case of infant botulism infection due to consumption of untreated well-water. ( 24461790 )
2014
33
Of war and sausages: a case-directed review of infant botulism. ( 23438300 )
2013
34
Infant botulism: advice on avoiding feeding honey to babies and other possible risk factors. ( 23914481 )
2013
35
A 3-month-old boy with concomitant respiratory syncytial virus bronchiolitis and infant botulism. ( 23328826 )
2013
36
Infant botulism: first two confirmed cases in Slovenia and literature review. ( 23707631 )
2013
37
Two cases of type A infant botulism in Grenoble, France: no honey for infants. ( 22159905 )
2012
38
Infant botulism and botulism immune globulin in the UK: a case series of four infants. ( 22294666 )
2012
39
Infant botulism following honey ingestion. ( 22962382 )
2012
40
Equine botulinum antitoxin for the treatment of infant botulism. ( 21918119 )
2011
41
Concerning the article "An infant botulism case occurred in Italy". ( 20424530 )
2010
42
First report worldwide of an infant botulism case due to Clostridium botulinum type E. ( 19906896 )
2010
43
Infant botulism in Australia: availability of human botulinum antitoxin for treatment. ( 21077820 )
2010
44
Infant botulism. ( 25610131 )
2010
45
Infant botulism intoxication and autonomic nervous system dysfunction. ( 19327405 )
2009
46
Phenotypic characterization of Clostridium botulinum strains isolated from infant botulism cases in Argentina. ( 19831311 )
2009
47
Infant botulism. ( 19636165 )
2009
48
Infant botulism mimicking Hirschprung's disease. ( 19853738 )
2009
49
Report of two unlinked cases of infant botulism in the UK in October 2007. ( 19661202 )
2009
50
Infant Botulism and Raised Intraocular Pressure. ( 19873952 )
2009

Variations for Infant Botulism

Expression for Infant Botulism

Search GEO for disease gene expression data for Infant Botulism.

Pathways for Infant Botulism

Pathways related to Infant Botulism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 NSF SNAP25 SYT1 SYT2 VAMP2
2 12.17 AVP NKX2-1 NSF SNAP25 SYT1 VAMP2
3
Show member pathways
12.08 AVP SYT1 SYT2 VAMP2
4
Show member pathways
11.89 SNAP25 SYT1 VAMP2
5 11.85 AVP SNAP25 VAMP2
6
Show member pathways
11.74 NSF SNAP25 SYT1 VAMP2
7
Show member pathways
11.46 SNAP25 SYT1 SYT2 VAMP2
8 11.19 AVP NSF VAMP2
9
Show member pathways
10.52 EEA1 NSF SNAP25 VAMP2
10 10.09 SNAP25 SYT1 VAMP2

GO Terms for Infant Botulism

Cellular components related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.96 SNAP25 SYT1 SYT2 VAMP2 VAPA
2 cytoplasmic vesicle GO:0031410 9.93 EEA1 NTS SYT1 SYT2 VAMP2
3 synapse GO:0045202 9.91 EEA1 SNAP25 SYT1 SYT2 VAMP2
4 neuron projection GO:0043005 9.77 CDC42 RARA SNAP25 SYT1 VAMP2
5 vesicle GO:0031982 9.75 SNAP25 VAMP2 VAPA
6 synaptic vesicle membrane GO:0030672 9.67 SYT1 SYT2 VAMP2
7 SNARE complex GO:0031201 9.58 SNAP25 SYT1 VAMP2
8 exocytic vesicle GO:0070382 9.57 SYT1 SYT2
9 neuron projection terminus GO:0044306 9.55 SYT1 VAMP2
10 dense core granule GO:0031045 9.52 SYT1 SYT2
11 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 9.48 SYT1 VAMP2
12 chromaffin granule membrane GO:0042584 9.46 SYT1 SYT2
13 synaptic vesicle GO:0008021 9.46 SNAP25 SYT1 SYT2 VAMP2
14 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 9.43 SYT1 VAMP2
15 clathrin-sculpted glutamate transport vesicle membrane GO:0060203 9.32 SYT1 VAMP2
16 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 9.26 SNAP25 VAMP2
17 secretory granule GO:0030141 9.13 AVP SYT1 VAMP2
18 clathrin-coated vesicle membrane GO:0030665 8.92 AVP SYT1 SYT2 VAMP2

Biological processes related to Infant Botulism according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 vesicle-mediated transport GO:0016192 9.71 NSF SYT1 SYT2 VAMP2
2 exocytosis GO:0006887 9.67 NSF SNAP25 VAMP2
3 locomotory behavior GO:0007626 9.61 AVP NKX2-1 SNAP25
4 synaptic vesicle endocytosis GO:0048488 9.58 SYT1 SYT2
5 regulation of dopamine secretion GO:0014059 9.57 SYT1 SYT2
6 vesicle fusion GO:0006906 9.56 EEA1 SNAP25
7 Golgi to plasma membrane protein transport GO:0043001 9.55 NSF VAMP2
8 positive regulation of dendrite extension GO:1903861 9.52 SYT1 SYT2
9 regulation of blood vessel size GO:0050880 9.51 AVP NTS
10 neurotransmitter secretion GO:0007269 9.5 SNAP25 SYT1 SYT2
11 glutamate secretion GO:0014047 9.48 SYT1 VAMP2
12 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.46 SYT1 SYT2
13 membrane organization GO:0061024 9.46 AVP SYT1 SYT2 VAMP2
14 regulation of exocytosis GO:0017157 9.43 NSF SYT1 VAMP2
15 viral RNA genome replication GO:0039694 9.37 CDC42 EEA1
16 positive regulation of intracellular protein transport GO:0090316 9.24 VAMP2
17 calcium ion regulated exocytosis GO:0017156 9.13 SYT1 SYT2 VAMP2
18 synaptic vesicle exocytosis GO:0016079 8.92 SNAP25 SYT1 SYT2 VAMP2

Molecular functions related to Infant Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.63 EEA1 SYT1 VAMP2
2 calcium-dependent protein binding GO:0048306 9.5 SNAP25 SYT1 VAMP2
3 SNARE binding GO:0000149 9.46 NSF SYT1 SYT2 VAMP2
4 neuropeptide hormone activity GO:0005184 9.43 AVP NTS
5 1-phosphatidylinositol binding GO:0005545 9.4 EEA1 SYT1
6 RNA polymerase II regulatory region DNA binding GO:0001012 9.37 NKX2-1 RARA
7 syntaxin-1 binding GO:0017075 9.26 NSF SNAP25 SYT1 VAMP2
8 syntaxin binding GO:0019905 9.02 NSF SNAP25 SYT1 SYT2 VAMP2
9 protein binding GO:0005515 10.13 BRD3 CDC42 EEA1 FBXW2 GPA33 LY96

Sources for Infant Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....