MCID: INF021
MIFTS: 32

Infant Gynecomastia

Categories: Fetal diseases

Aliases & Classifications for Infant Gynecomastia

MalaCards integrated aliases for Infant Gynecomastia:

Name: Infant Gynecomastia 12 72
Gynecomastia 44 72
Breast Engorgement in Newborn 12
Neonatal Gynaecomastia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11603
ICD9CM 35 778.7
MeSH 44 D006177
NCIt 50 C117312
SNOMED-CT 68 34831003
ICD10 33 P83.4
UMLS 72 C0018418 C1449721

Summaries for Infant Gynecomastia

Disease Ontology : 12 A breast disease that is characterized by benign proliferation of glandular breast tissue and occurs in children less than one year of age.

MalaCards based summary : Infant Gynecomastia, also known as gynecomastia, is related to gynecomastia and aromatase excess syndrome. The drugs Eplerenone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and liver.

Related Diseases for Infant Gynecomastia

Diseases related to Infant Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 12.9
2 aromatase excess syndrome 12.4
3 wilson-turner x-linked mental retardation syndrome 12.3
4 17-beta hydroxysteroid dehydrogenase iii deficiency 12.3
5 spinal and bulbar muscular atrophy, x-linked 1 11.8
6 hypogonadotropic hypogonadism 11.7
7 androgen insensitivity, partial 11.6
8 androgen insensitivity syndrome 11.5
9 testicular seminoma 11.5
10 borjeson-forssman-lehmann syndrome 11.3
11 46,xx sex reversal 1 11.3
12 mental retardation, x-linked, syndromic, turner type 11.2
13 alopecia, neurologic defects, and endocrinopathy syndrome 11.1
14 48,xxxy syndrome 11.1
15 48,xxyy syndrome 11.1
16 49, xxxyy syndrome 11.1
17 49,xxxxy syndrome 11.1
18 hypogonadism 10.6
19 hypogonadotropism 10.6
20 breast cancer 10.5
21 leydig cell tumor 10.4
22 hyperthyroidism 10.4
23 galactorrhea 10.4
24 hyperprolactinemia 10.4
25 testicular cancer 10.3
26 in situ carcinoma 10.3
27 peutz-jeghers syndrome 10.3
28 ductal carcinoma in situ 10.3
29 breast disease 10.3
30 liver cirrhosis 10.3
31 ptosis 10.3
32 hypospadias 10.3
33 liver disease 10.3
34 neurofibromatosis, type iv, of riccardi 10.2
35 prostate cancer 10.2
36 estrogen excess 10.2
37 impotence 10.2
38 pseudohermaphroditism 10.2
39 leprosy 3 10.2
40 pulmonary tuberculosis 10.2
41 hansen's disease 10.2
42 papilloma 10.2
43 sertoli cell tumor 10.2
44 precocious puberty 10.2
45 lung cancer 10.2
46 mastitis 10.2
47 adrenocortical carcinoma, hereditary 10.1
48 graves disease 1 10.1
49 adrenal cortical carcinoma 10.1
50 squamous cell papilloma 10.1

Graphical network of the top 20 diseases related to Infant Gynecomastia:



Diseases related to Infant Gynecomastia

Symptoms & Phenotypes for Infant Gynecomastia

Drugs & Therapeutics for Infant Gynecomastia

Drugs for Infant Gynecomastia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
4
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
5
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
6 Antihypertensive Agents Phase 4
7 Antidepressive Agents Phase 4
8 Tranquilizing Agents Phase 4
9 Quetiapine Fumarate Phase 4 111974-72-2
10 Antipsychotic Agents Phase 4
11 Psychotropic Drugs Phase 4
12 Neurotransmitter Agents Phase 4
13 Serotonin Receptor Agonists Phase 4
14 Serotonin 5-HT2 Receptor Antagonists Phase 4
15 Dopamine Agents Phase 4
16 Serotonin 5-HT1 Receptor Agonists Phase 4
17 Serotonin Antagonists Phase 4
18 Serotonin Agents Phase 4
19 Dopamine Antagonists Phase 4
20 Dopamine agonists Phase 4
21 Dopamine D2 Receptor Antagonists Phase 4
22 Liver Extracts Phase 4
23 Protective Agents Phase 4
24 Antioxidants Phase 4
25 Lipid Regulating Agents Phase 4
26 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
27 Hypolipidemic Agents Phase 4
28 Antimetabolites Phase 4
29 Anticholesteremic Agents Phase 4
30 Central Nervous System Depressants Phase 4
31 Anesthetics, Local Phase 4
32 Anesthetics Phase 4
33 Peripheral Nervous System Agents Phase 4
34
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
35
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
36
Tamoxifen Approved Phase 3 10540-29-1 2733526
37
Testosterone enanthate Approved Phase 3 315-37-7 9416
38
Methyltestosterone Approved Phase 3 58-18-4 6010
39
Testosterone Approved, Experimental, Investigational Phase 3 481-30-1, 58-22-0 6013 10204
40
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
41
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
42
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
43
Bicalutamide Approved Phase 3 90357-06-5 56069 2375
44
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
45
Polyestradiol phosphate Approved Phase 3 28014-46-2
46
Goserelin Approved Phase 3 65807-02-5, 1233494-97-7 47725 5311128
47
Flutamide Approved, Investigational Phase 3 13311-84-7 3397
48
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
49
Dihydrotestosterone Illicit, Investigational Phase 3 521-18-6 10635
50 Steroid Synthesis Inhibitors Phase 3

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Changes of Heart Rate Variability in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine Unknown status NCT01047215 Phase 4 Aripiprazole; Quetiapine
2 Does Aldosterone Cause Hypertension by a Non-Renal Mechanism? Unknown status NCT00553722 Phase 4 Eplerenone;Placebo
3 The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment Completed NCT03121521 Phase 4 Melatonin 10 mg;Placebo
4 EFFICACY EVALUATION OF PRUNUS DOMESTICA EXTRACT ON BENIGN PROSTATE HYPERPLASIA (BPH): An Add on Study Completed NCT02702947 Phase 4
5 Does Stellate Ganglion Blockade (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes? A Pilot Prospective Cohort Study Not yet recruiting NCT03796195 Phase 4 .5% Bupivacaine
6 An OptioExtension of Trial 1033US/0006 to Assess Safety, Tolerability, Efficacy of Anastrozole (ZD1033, Arimidex™) in Treatment of Gynecomastia in Pubertal Boys Given Placebo and to Conduct a Long-Term Safety Follow-Up of Non-Responding Subjects Given Anastrozole in the Previous Trial Completed NCT00637182 Phase 3 Anastrozole
7 A Comparative Trial of the Efficacy of Two Different Nolvadex (NDX) Dosing and Scheduling Regimens in Preventing Gynecomastia Induced by Casodex (CDX) 150 Monotherapy in Prostate Cancer Patients. An Open, Multicenter, Phase III Trial. Completed NCT00233610 Phase 3 Bicalutamide;Tamoxifen
8 Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals) Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
9 A Randomized-Controlled Trial of Transcutaneous Oestrogen Patches Versus LHRH Agonists in Prostate Cancer Recruiting NCT00303784 Phase 3 Goserelin;Estradiol
10 Usefulness of Spironolactone for the Prevention of Acute Kidney Injury in Critically Ill Patients With Invasive Mechanical Ventilation Not yet recruiting NCT03206658 Phase 3 Spironolactone 25 mg;Placebo oral capsule
11 An Open-Label Pharmacokinetic and Pharmacodynamic Study of Anastrozole (Arimidex™) Used to Treat Pubertal Boys With Gynecomastia of Recent Onset Completed NCT00241436 Phase 2 Anastrozole (ARIMIDEX™)
12 Randomised, Double-blind, Placebo Controlled, Parallel-group, Multicentre Phase II Study to Assess Dose Response Relationship of Nolvadex (Oral Tablet) in Prophylactic Treatment of Gynaecomastia and Breast Pain Associated With CASODEX 150 mg (Oral Tablet), and to Assess the Tumour Control….. Completed NCT00637871 Phase 2 Casodex;Tamoxifen
13 Spironolactone and Testolactone Treatment of Boys With Familial Isosexual Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
14 5-Alpha Reductase and Anabolic Effects of Testosterone Completed NCT00475501 Phase 2 Testosterone Enanthate;Finasteride
15 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Completed NCT03174171 Phase 2 Everolimus 0.75 mg
16 Phase II, Open Label, Dose Finding Study of the Effect of GTx-758 on Total and Free Testosterone Levels in Men With Prostate Cancer Compared to a Luteinizing Hormone Releasing Hormone Agonist Terminated NCT01326312 Phase 2 GTx-758;Lupron Depot;GTx-758
17 A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study of BHR-200 (0.36% Transdermal Estradiol Gel) for the Maintenance of Testosterone Suppression in Men With Advanced Androgen-Sensitive Prostate Cancer Terminated NCT02349386 Phase 2 BHR-200 (0.36% transdermal 17β-estradiol gel);Placebo
18 Transplantation of Expanded and Unexpanded Umbilical Cord Blood Units Following Myeloablative Chemotherapy for Hematologic Malignancies Terminated NCT00539656 Phase 1, Phase 2
19 A Randomized, Double-Blind Placebo-Controlled Study of 3,5-diiodothyropropionic Acid (DITPA) in Combination With Standard Therapy to Attain NCEP ATP III Goal for LDL Cholesterol in Hypercholesterolemic Patients Terminated NCT00311987 Phase 1, Phase 2 3,5-Diiodothyropropionic acid (DITPA) therapy
20 Swedish, Multicentered, Randomized Study of Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis Regarding Efficacy and Side Effects Withdrawn NCT01801228 Phase 2 Eplerenone
21 A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD Recruiting NCT03777319 Phase 1 Spironolactone;Prednisolone
22 Targeted Fat Reduction of Pseudogynecomastia in the Male Breast Using the ZELTIQ Coolsculpting System Unknown status NCT01791660
23 Effect of Type and Severity of Liver Cirrhosis on Semen Parameters and Reproductive Hormones Unknown status NCT03167749
24 Post-massive Weight Loss Chest Contouring: Inferior Pedicle Technique in Pseudo-gynecomastia Correction Completed NCT03319862
25 A Randomized Controlled Trial Modified Benelli Procedure For Subcutaneous Mastectomy In Gynecomastia Completed NCT04063722
26 Changes in Hyperprolactinemia Secondary to Antipsychotics After Switching to Quetiapine: a Naturalistic, Prospective, Multicentric Observational Study of 6 Months Follow-up Completed NCT00952757
27 Adaptation Among Adolescents and Adults With Klinefelter Syndrome Completed NCT00896272
28 Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment - Retrospective Experience From a Single Tertiary Referral Centre 1990-2013 Completed NCT02034487
29 Management of Azoospermic Patients With Kleinfelter Syndrome Patients With Mesenchymal Stem Cell Injection Completed NCT02414295 Mesenchymal stem cell injection
30 Spironolactone for Reducing Proteinuria in Diabetic Nephropathy Completed NCT00498537 spironolactone
31 Impact of Strength Training With Vascular Occlusion on the Syndrome Lipodystrophy in Patients Harboring With HIV/Aids Terminated NCT02783417
32 Clinical Evaluation of the UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia) Withdrawn NCT02711605

Search NIH Clinical Center for Infant Gynecomastia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Tamoxifen
Tamoxifen Citrate

Cochrane evidence based reviews: gynecomastia

Genetic Tests for Infant Gynecomastia

Anatomical Context for Infant Gynecomastia

MalaCards organs/tissues related to Infant Gynecomastia:

41
Breast, Prostate, Liver, Testis, Heart, Lung, Pituitary

Publications for Infant Gynecomastia

Articles related to Infant Gynecomastia:

(show top 50) (show all 3040)
# Title Authors PMID Year
1
Correction of Tuberous Nipple Areolar Complex Deformity in Gynecomastia: The Deformity That Can Get Forgotten. 38
30161048 2019
2
Anabolic-androgenic Steroid Use Among Gynecomastia Patients: Prevalence and Relevance to Surgical Management. 38
31021838 2019
3
Male Breast Disease: What the Radiologist Needs to Know. 38
30122313 2019
4
Lavender products associated with premature thelarche and prepubertal gynecomastia: Case reports and EDC activities. 38
31393563 2019
5
Innovative Technique to Improve Chest Shape following Gynecomastia Correction in Post-Bariatric Surgery Patients. 38
31348385 2019
6
Closed-Suction Drains After Subcutaneous Mastectomy for Gynecomastia: Do they Reduce Complications? 38
29302730 2019
7
Gynecomastia in HIV-positive adult men receiving efavirenz-based antiretroviral therapy at Newlands clinic, Harare, Zimbabwe. 38
31409277 2019
8
Reply: Treatment of Severe Gynecomastia after Massive Weight Loss: Analysis of Long-Term Outcomes Measured with the Italian Version of the BODY-Q. 38
31348386 2019
9
Reply: Treatment of Severe Gynecomastia after Massive Weight Loss: Analysis of Long-Term Outcomes Measured with the Italian Version of the BODY-Q. 38
31348388 2019
10
Treatment of Gynecomastia by Endoscopic Subcutaneous Mastectomy in Adolescents. 38
31216208 2019
11
Demographics, Usage Patterns, and Safety of Male Users of Clomiphene in the United States. 38
31385473 2019
12
Relative Efficacy of Spironolactone, Eplerenone, and cAnRenone in patients with Chronic Heart failure (RESEARCH): a systematic review and network meta-analysis of randomized controlled trials. 38
31364027 2019
13
High expression of adrenal P450 aromatase (CYP19A1) in association with ARMC5-primary bilateral macronodular adrenocortical hyperplasia. 38
31014964 2019
14
Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation. 38
31274478 2019
15
45,X/46,X,i(Yp): Importance of Assessment and Support during Puberty and Adolescence. 38
31266049 2019
16
Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms. 38
30910348 2019
17
Testosterone undecanoate supplementation together with human chorionic gonadotropin does not impair spermatogenesis in males with isolated hypogonadotropic hypogonadism: a retrospective study. 38
30604694 2019
18
46,XX Testicular Disorder of Sex Development (DSD): A Case Report and Systematic Review. 38
31336995 2019
19
Comparison of curative effects between mammotome-assisted minimally invasive resection (MAMIR) and traditional open surgery for gynecomastia in Chinese patients: A prospective clinical study. 38
31267613 2019
20
Defining the Aesthetic Units of the Male Chest and How They Relate to Gynecomastia Based on 635 Patients. 38
31246853 2019
21
Reply: Defining the Aesthetic Units of the Male Chest and How They Relate to Gynecomastia Based on 635 Patients. 38
31246854 2019
22
Critique of "Risk of Gynecomastia with Users of Proton Pump Inhibitors". 38
31063650 2019
23
Alternative Viewpoint of "Risk of Gynecomastia with Users of Proton Pump Inhibitors". 38
31067343 2019
24
An analysis of online content related to testosterone supplementation. 38
29921150 2019
25
Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents. 38
31093949 2019
26
Pseudoangiomatous Stromal Hyperplasia of the Breast: A Rare Finding in a Male Patient. 38
31423399 2019
27
Vacuum-assisted minimally invasive surgery-An innovative method for the operative treatment of gynecomastia. 38
31248653 2019
28
Male Tuberous Breast: A Rare Variant of Gynecomastia. Clinical Considerations and Personal Experience: Tips and Tricks to Maximize Surgical Outcomes. 38
31218378 2019
29
3D Mammometric Changes in the Treatment of Idiopathic Gynecomastia. 38
30815735 2019
30
Adverse events during testosterone replacement therapy in 95 young hypogonadal thalassemic men. 38
31125000 2019
31
Early Experience With Body Contouring Procedures in Patients With End-Stage Renal Disease Awaiting Renal Transplant. 38
30882411 2019
32
Surgical Site Infection Risk Factor Analysis in Postbariatric Patients Undergoing Body Contouring Surgery: A Nested Case-Control Study. 38
30950874 2019
33
Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? 38
30666539 2019
34
Treatment of gynecomastia with prednisone: case report and literature review. 38
30958070 2019
35
Is gynecomastia related to the disease characteristics and prognosis in testicular germ cell tumor patients? 38
31063146 2019
36
Clinical manifestations and AR gene mutations in Kennedy's disease. 38
30612224 2019
37
The Utility of Google Trends Data for Analyzing Public Interest in Breast Procedures. 38
30870175 2019
38
Hand Pattern Based on Second-to-Fourth Digit Ratio: Its Relationship to Sex, Body Mass Index, and Physical Activity. 38
31333925 2019
39
[Subacute myopathy in a patient with mild Cushing disease manifested by accompanying Kleinfelter syndrome]. 38
31061299 2019
40
Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey 38
30396878 2019
41
Surgical Management of Gynecomastia: A Review of the Current Insurance Coverage Criteria. 38
31033818 2019
42
The round-the-clock technique for correction of gynecomastia. 38
31113185 2019
43
Clinical and Biochemical Phenotype of Adolescent Males with Gynecomastia 38
31117335 2019
44
EAA clinical practice guidelines-gynecomastia evaluation and management. 38
31099174 2019
45
Risk of Gynecomastia with Users of Proton Pump Inhibitors. 38
30865318 2019
46
"Reply to Innovative technique to improve chest shape following gynecomastia correction in post-bariatric patients." 38
31188293 2019
47
Innovative technique to improve chest shape following gynecomastia correction in post-bariatric patients. 38
31188297 2019
48
Clomiphene Citrate for the Treatment of Hypogonadism. 38
30522888 2019
49
Off-label use of tamoxifen in a Chinese tertiary care hospital. 38
30680514 2019
50
Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial. 38
30473139 2019

Variations for Infant Gynecomastia

Expression for Infant Gynecomastia

Search GEO for disease gene expression data for Infant Gynecomastia.

Pathways for Infant Gynecomastia

GO Terms for Infant Gynecomastia

Sources for Infant Gynecomastia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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