MCID: INF021
MIFTS: 31

Infant Gynecomastia

Categories: Fetal diseases

Aliases & Classifications for Infant Gynecomastia

MalaCards integrated aliases for Infant Gynecomastia:

Name: Infant Gynecomastia 12 71
Gynecomastia 43 71
Breast Engorgement in Newborn 12
Neonatal Gynaecomastia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11603
ICD9CM 34 778.7
MeSH 43 D006177
NCIt 49 C117312
SNOMED-CT 67 34831003
ICD10 32 P83.4
UMLS 71 C0018418 C1449721

Summaries for Infant Gynecomastia

Disease Ontology : 12 A breast disease that is characterized by benign proliferation of glandular breast tissue and occurs in children less than one year of age.

MalaCards based summary : Infant Gynecomastia, also known as gynecomastia, is related to gynecomastia and aromatase excess syndrome. The drugs Eplerenone and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and liver.

Related Diseases for Infant Gynecomastia

Diseases related to Infant Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 12.8
2 aromatase excess syndrome 12.4
3 wilson-turner x-linked mental retardation syndrome 12.4
4 17-beta hydroxysteroid dehydrogenase iii deficiency 12.3
5 spinal and bulbar muscular atrophy, x-linked 1 11.8
6 hypogonadotropic hypogonadism 11.6
7 androgen insensitivity, partial 11.6
8 androgen insensitivity syndrome 11.5
9 testicular seminoma 11.5
10 borjeson-forssman-lehmann syndrome 11.3
11 46,xx sex reversal 1 11.3
12 mental retardation, x-linked, syndromic, turner type 11.2
13 alopecia, neurologic defects, and endocrinopathy syndrome 11.1
14 48,xxxy syndrome 11.1
15 48,xxyy syndrome 11.1
16 49, xxxxy syndrome 11.1
17 49, xxxyy syndrome 11.1
18 hypogonadism 10.6
19 breast cancer 10.5
20 leydig cell tumor 10.5
21 hyperthyroidism 10.4
22 galactorrhea 10.4
23 hyperprolactinemia 10.4
24 testicular cancer 10.3
25 in situ carcinoma 10.3
26 peutz-jeghers syndrome 10.3
27 ductal carcinoma in situ 10.3
28 breast disease 10.3
29 liver cirrhosis 10.3
30 ptosis 10.3
31 hypospadias 10.3
32 estrogen excess 10.3
33 liver disease 10.3
34 prostate cancer 10.2
35 impotence 10.2
36 pseudohermaphroditism 10.2
37 neurofibromatosis 10.2
38 leprosy 3 10.2
39 pulmonary tuberculosis 10.2
40 hansen's disease 10.2
41 papilloma 10.2
42 sertoli cell tumor 10.2
43 precocious puberty 10.2
44 lung cancer 10.2
45 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.2
46 mastitis 10.2
47 adrenocortical carcinoma, hereditary 10.1
48 graves disease 1 10.1
49 adrenal cortical carcinoma 10.1
50 squamous cell papilloma 10.1

Graphical network of the top 20 diseases related to Infant Gynecomastia:



Diseases related to Infant Gynecomastia

Symptoms & Phenotypes for Infant Gynecomastia

Drugs & Therapeutics for Infant Gynecomastia

Drugs for Infant Gynecomastia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
5
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
6
Methyltestosterone Approved Phase 4 58-18-4 6010
7
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
8
Testosterone enanthate Approved Phase 4 315-37-7 9416
9
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
10
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
11 Antihypertensive Agents Phase 4
12 Antipsychotic Agents Phase 4
13 Dopamine Agents Phase 4
14 Neurotransmitter Agents Phase 4
15 Dopamine agonists Phase 4
16 Dopamine Antagonists Phase 4
17 Antidepressive Agents Phase 4
18 Serotonin 5-HT1 Receptor Agonists Phase 4
19 Serotonin Receptor Agonists Phase 4
20 Psychotropic Drugs Phase 4
21 Quetiapine Fumarate Phase 4 111974-72-2
22 Liver Extracts Phase 4
23 Antioxidants Phase 4
24 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
25 Protective Agents Phase 4
26 Anesthetics Phase 4
27 Anesthetics, Local Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Mineralocorticoids Phase 4
30 Mineralocorticoid Receptor Antagonists Phase 4
31 diuretics Phase 4
32 Diuretics, Potassium Sparing Phase 4
33 Testosterone 17 beta-cypionate Phase 4
34 Anabolic Agents Phase 4
35 Sodium Channel Blockers Phase 4
36
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
37
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
38
Tamoxifen Approved Phase 3 10540-29-1 2733526
39
Testosterone Approved, Experimental, Investigational Phase 3 58-22-0, 481-30-1 10204 6013
40
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
41
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
42
Bicalutamide Approved Phase 3 90357-06-5 2375 56069
43
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
44
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
45
Polyestradiol phosphate Approved Phase 3 28014-46-2
46
Flutamide Approved, Investigational Phase 3 13311-84-7 3397
47
Goserelin Approved Phase 3 65807-02-5 5311128 47725
48
Dihydrotestosterone Illicit, Investigational Phase 3 521-18-6 10635
49 Estrogen Antagonists Phase 3
50 Estrogen Receptor Antagonists Phase 3

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Changes of Heart Rate Variability in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine Unknown status NCT01047215 Phase 4 Aripiprazole; Quetiapine
2 Does Aldosterone Cause Hypertension by a Non-Renal Mechanism? Unknown status NCT00553722 Phase 4 Eplerenone;Placebo
3 The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment Completed NCT03121521 Phase 4 Melatonin 10 mg;Placebo
4 EFFICACY EVALUATION OF PRUNUS DOMESTICA EXTRACT ON BENIGN PROSTATE HYPERPLASIA (BPH): An Add on Study Completed NCT02702947 Phase 4
5 Does Stellate Ganglion Blockade (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes? A Pilot Prospective Cohort Study Recruiting NCT03796195 Phase 4 .5% Bupivacaine
6 A Comparison of Side Effects in Hypogonadal Men Treated With Natesto Versus Testosterone Injections: A Phase IV, Prospective, Randomized, Non-Blinded, Multi-Institutional Study Not yet recruiting NCT04439799 Phase 4 Testosterone Cypionate 200 MG/ML;Intranasal Testosterone
7 SPironolactone Versus Amiloride for Treatment of REsistant Hypertension (SPARE Trial): A Comparison of Home Blood Pressure Not yet recruiting NCT04331691 Phase 4 Spironolactone;Amiloride
8 Usefulness of Spironolactone for the Prevention of Acute Kidney Injury in Critically Ill Patients With Invasive Mechanical Ventilation Unknown status NCT03206658 Phase 3 Spironolactone 25 mg;Placebo oral capsule
9 An OptioExtension of Trial 1033US/0006 to Assess Safety, Tolerability, Efficacy of Anastrozole (ZD1033, Arimidex™) in Treatment of Gynecomastia in Pubertal Boys Given Placebo and to Conduct a Long-Term Safety Follow-Up of Non-Responding Subjects Given Anastrozole in the Previous Trial Completed NCT00637182 Phase 3 Anastrozole
10 A Comparative Trial of the Efficacy of Two Different Nolvadex (NDX) Dosing and Scheduling Regimens in Preventing Gynecomastia Induced by Casodex (CDX) 150 Monotherapy in Prostate Cancer Patients. An Open, Multicenter, Phase III Trial. Completed NCT00233610 Phase 3 Bicalutamide;Tamoxifen
11 Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals) Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
12 Topical Nitroglycerin as a Mechanism for Cutaneous Vaso-modulation and Improved Wound Healing After Breast Reduction Recruiting NCT04321967 Phase 3 Nitroglycerin Paste;Dermabond
13 A Randomized-Controlled Trial of Transcutaneous Oestrogen Patches Versus LHRH Agonists in Prostate Cancer Recruiting NCT00303784 Phase 3 Goserelin;Estradiol
14 An Open-Label Pharmacokinetic and Pharmacodynamic Study of Anastrozole (Arimidex™) Used to Treat Pubertal Boys With Gynecomastia of Recent Onset Completed NCT00241436 Phase 2 Anastrozole (ARIMIDEX™)
15 Randomised, Double-blind, Placebo Controlled, Parallel-group, Multicentre Phase II Study to Assess Dose Response Relationship of Nolvadex (Oral Tablet) in Prophylactic Treatment of Gynaecomastia and Breast Pain Associated With CASODEX 150 mg (Oral Tablet), and to Assess the Tumour Control….. Completed NCT00637871 Phase 2 Casodex;Tamoxifen
16 Spironolactone and Testolactone Treatment of Boys With Familial Isosexual Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
17 5-Alpha Reductase and Anabolic Effects of Testosterone Completed NCT00475501 Phase 2 Testosterone Enanthate;Finasteride
18 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Completed NCT03174171 Phase 2 Everolimus 0.75 mg
19 Phase II, Open Label, Dose Finding Study of the Effect of GTx-758 on Total and Free Testosterone Levels in Men With Prostate Cancer Compared to a Luteinizing Hormone Releasing Hormone Agonist Terminated NCT01326312 Phase 2 GTx-758;Lupron Depot;GTx-758
20 A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study of BHR-200 (0.36% Transdermal Estradiol Gel) for the Maintenance of Testosterone Suppression in Men With Advanced Androgen-Sensitive Prostate Cancer Terminated NCT02349386 Phase 2 BHR-200 (0.36% transdermal 17β-estradiol gel);Placebo
21 Transplantation of Expanded and Unexpanded Umbilical Cord Blood Units Following Myeloablative Chemotherapy for Hematologic Malignancies Terminated NCT00539656 Phase 1, Phase 2
22 A Randomized, Double-Blind Placebo-Controlled Study of 3,5-diiodothyropropionic Acid (DITPA) in Combination With Standard Therapy to Attain NCEP ATP III Goal for LDL Cholesterol in Hypercholesterolemic Patients Terminated NCT00311987 Phase 1, Phase 2 3,5-Diiodothyropropionic acid (DITPA) therapy
23 Swedish, Multicentered, Randomized Study of Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis Regarding Efficacy and Side Effects Withdrawn NCT01801228 Phase 2 Eplerenone
24 A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD Recruiting NCT03777319 Phase 1 Spironolactone;Prednisolone
25 Targeted Fat Reduction of Pseudogynecomastia in the Male Breast Using the ZELTIQ Coolsculpting System Unknown status NCT01791660
26 Effect of Type and Severity of Liver Cirrhosis on Semen Parameters and Reproductive Hormones Unknown status NCT03167749
27 Post-massive Weight Loss Chest Contouring: Inferior Pedicle Technique in Pseudo-gynecomastia Correction Completed NCT03319862
28 A Randomized Controlled Trial Modified Benelli Procedure For Subcutaneous Mastectomy In Gynecomastia Completed NCT04063722
29 Changes in Hyperprolactinemia Secondary to Antipsychotics After Switching to Quetiapine: a Naturalistic, Prospective, Multicentric Observational Study of 6 Months Follow-up Completed NCT00952757
30 Adaptation Among Adolescents and Adults With Klinefelter Syndrome Completed NCT00896272
31 Management of Azoospermic Patients With Kleinfelter Syndrome Patients With Mesenchymal Stem Cell Injection Completed NCT02414295 Mesenchymal stem cell injection
32 Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment - Retrospective Experience From a Single Tertiary Referral Centre 1990-2013 Completed NCT02034487
33 Spironolactone for Reducing Proteinuria in Diabetic Nephropathy Completed NCT00498537 spironolactone
34 Thoracic Interfascial Plane Block Versus Thoracic Paravertebral Block for Anesthesia in Gynecomastia Surgery: A Randomized Controlled Trial Recruiting NCT04425447 Tumescent local anesthesia;Thoracic paravertebral block;Thoracic interfascial plane block
35 Ultrasound Guided Modified Pectoral Plane (PECS II )Block Versus Erector Spinae Plane (ESP) Block for Perioperative Analgesia of Surgical Treatment of Gynecomastia Not yet recruiting NCT04221074
36 Impact of Strength Training With Vascular Occlusion on the Syndrome Lipodystrophy in Patients Harboring With HIV/Aids Terminated NCT02783417
37 Clinical Evaluation of the UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia) Withdrawn NCT02711605

Search NIH Clinical Center for Infant Gynecomastia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Tamoxifen
Tamoxifen Citrate

Cochrane evidence based reviews: gynecomastia

Genetic Tests for Infant Gynecomastia

Anatomical Context for Infant Gynecomastia

MalaCards organs/tissues related to Infant Gynecomastia:

40
Breast, Prostate, Liver, Testis, Heart, Lung, Pituitary

Publications for Infant Gynecomastia

Articles related to Infant Gynecomastia:

(show top 50) (show all 3118)
# Title Authors PMID Year
1
Letter to the Editor: "Lavender Products Associated With Premature Thelarche and Prepubertal Gynecomastia: Case Reports and Endocrine-Disrupting Chemical Activities". 61
32379885 2020
2
Response to Letter to the Editor: "Lavender products associated with premature thelarche and prepubertal gynecomastia: Case reports and EDC activities". 61
32379886 2020
3
Venous malformation of the pectoral muscle depicted on mammogram. 61
32145447 2020
4
Treatment strategies to prevent and reduce gynecomastia and/or breast pain caused by antiandrogen therapy for prostate cancer : Statement from the DEGRO working group prostate cancer. 61
32166452 2020
5
Prospective Analysis and Comparison of Periareolar Excision (Delivery) Technique and Pull-Through Technique for the Treatment of Gynecomastia. 61
32100080 2020
6
Prospective Analysis and Comparison of Periareolar Excision (Delivery) and Pull-Through Technique for the Treatment of Gynecomastia. 61
32185498 2020
7
Response to Letter to the Editor: Lavender products associated with premature thelarche and prepubertal gynecomastia: Case reports and EDC activities. 61
32575119 2020
8
Invited Response on: Prospective Analysis and Comparison of Periareolar Excision (Delivery) Technique and Pull-Through Technique for the Treatment of Gynecomastia. 61
32246213 2020
9
Invited Discussion on: Prospective Analysis and Comparison of Periareolar Excision (Delivery) Technique and Pull-through Technique for the Treatment of Gynecomastia. 61
32133559 2020
10
Invited Response on: Prospective Analysis and Comparison of Periareolar Excision (Delivery) Technique and Pull-Through Technique for the Treatment of Gynecomastia. 61
32144467 2020
11
Bilateral gynecomastia secundary to extramedular plasmocytoma. 61
31928981 2020
12
Prospective Analysis and Comparison of Periareolar Excision (Delivery) Technique and Pull-Through Technique for the Treatment of Gynecomastia. 61
31989232 2020
13
The drugs that mostly frequently induce gynecomastia: A national case - noncase study. 61
31471065 2020
14
Incidental Gynecomastia on Thoracic Computed Tomography in Clinical Practice: Characteristics, Radiologic Features, and Correlation With Possible Causes in South Korean Men. 61
32456508 2020
15
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data. 61
31845841 2020
16
Metabolic and cardiovascular risk factors in Klinefelter syndrome. 61
32452627 2020
17
COVID-19 and Gynecomastia: What is the Relationship? 61
32418781 2020
18
Gonadotropin Treatment For The Male Hypogonadotropic Hypogonadism. 61
32445446 2020
19
Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation. 61
31274478 2020
20
Single-port endoscopic mastectomy via the lateral chest approach for the treatment of grade II gynecomastia. 61
32481376 2020
21
A Novel Missense Variant in PHF6 Gene Causing Börjeson-Forssman-Lehman Syndrome. 61
32399860 2020
22
Gynecomastia: A Rare Adverse Effect of Methylphenidate in an Adolescent Boy. 61
32329315 2020
23
Multiple symmetric lipomatosis of the male breast: An unusual mimic of gynecomastia. 61
32367886 2020
24
Atypical gynecomastia mimicking breast malignancy on mammography, sonography, and 18F-fluciclovine PET/CT in the setting of biochemical recurrence of prostate cancer. 61
32255528 2020
25
Findings of Gynecomastia That Developed in Follow-up Secondary to Bicalutamide Treatment on Bone Scan. 61
32368880 2020
26
Sex Hormone Profile in Pubertal Boys With Gynecomastia and Pseudogynecomastia. 61
31996898 2020
27
Case 4: Gynecomastia in a 15-year-old Boy. 61
32238551 2020
28
Demographics, Usage Patterns, and Safety of Male Users of Clomiphene in the United States. 61
31385473 2020
29
Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer. 61
32295201 2020
30
Comparative study of spironolactone and eplerenone in management of ascites in patients of cirrhosis of liver. 61
32044820 2020
31
The French national protocol for Kennedy's disease (SBMA): consensus diagnostic and management recommendations. 61
32276665 2020
32
Development of gynecomastia following initiation of bictegravir/emtricitabine/tenofovir alafenamide. 61
32041480 2020
33
The relationship between lavender and tea tree essential oils and pediatric endocrine disorders: A systematic review of the literature. 61
32147050 2020
34
Relative Efficacy of Spironolactone, Eplerenone, and cAnRenone in patients with Chronic Heart failure (RESEARCH): a systematic review and network meta-analysis of randomized controlled trials. 61
31364027 2020
35
Gynecomastia or rare malignancy? A young man with an unremarkable history proves to have adenoid cystic carcinoma of the breast. 61
31493308 2020
36
Review of the microdebrider excision and liposuction technique (MELT) for the treatment of gynecomastia. 61
31672463 2020
37
Imaging findings and classification of the common and uncommon male breast diseases. 61
32072386 2020
38
Dutasteride in the long-term management of stuttering priapism. 61
32055472 2020
39
[A survey of Belgian practice for non-malignant diseases]. 61
31980359 2020
40
The pleura and the endocrine system. 61
31918926 2020
41
Radiation Therapy for Benign Disease: Arteriovenous Malformations, Desmoid Tumor, Dupuytren Contracture, Graves Ophthalmopathy, Gynecomastia, Heterotopic Ossification, Histiocytosis. 61
31739945 2020
42
Prolactin serial sampling as a confirmatory test for true hyperprolactinemia. 61
32113859 2020
43
Male Gynecomastia Correction by Superior Dynamic Flap Method: A Consistent and Versatile Technique. 61
32190589 2020
44
Gynecomastia in multi-drug resistant tuberculosis - ethionamide the villain. 61
32383471 2020
45
Gynecomastia after Botulinum Toxin Injections for Poststroke Spasticity. 61
31903667 2020
46
46,XX male disorder of sexual development. 61
32029971 2020
47
Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: An Uncommon Finding in an Uncommon Patient. 61
31941879 2020
48
Combined Long-Term Androgen Deprivation and Pelvic Radiotherapy in the Post-operative Management of Pathologically Defined High-Risk Prostate Cancer Patients: Results of the Prospective Phase II McGill 0913 Study. 61
32226774 2020
49
PREPUBERTAL GYNECOMASTIA: A RARE MANIFESTATION OF MYOTONIC DYSTROPHY TYPE 1. 61
32074227 2020
50
Pain, fatigue and depression symptom cluster in survivors of prostate cancer. 61
31980895 2020

Variations for Infant Gynecomastia

Expression for Infant Gynecomastia

Search GEO for disease gene expression data for Infant Gynecomastia.

Pathways for Infant Gynecomastia

GO Terms for Infant Gynecomastia

Sources for Infant Gynecomastia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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