IDF
MCID: INF046
MIFTS: 36

Infantile Digital Fibromatosis (IDF)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Infantile Digital Fibromatosis

MalaCards integrated aliases for Infantile Digital Fibromatosis:

Name: Infantile Digital Fibromatosis 53 59 73
Asymptomatic Nodular Proliferation of Fibrous Tissue on the Dorsal and Lateral Aspects of the Fingers or Toes 53
Recurring Digital Fibrous Tumor of Childhood 59
Inclusion Body Fibromatosis 59
Reye Tumor 59
Idf 53

Characteristics:

Orphanet epidemiological data:

59
infantile digital fibromatosis
Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA199267
UMLS via Orphanet 74 C1318562
ICD10 via Orphanet 34 M72.8
UMLS 73 C1318562

Summaries for Infantile Digital Fibromatosis

MalaCards based summary : Infantile Digital Fibromatosis, also known as asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes, is related to fibromatosis and benign breast phyllodes tumor. An important gene associated with Infantile Digital Fibromatosis is DES (Desmin), and among its related pathways/superpathways are Cytoskeleton remodeling Neurofilaments and Cytoskeletal Signaling. Affiliated tissues include skin, breast and cervix, and related phenotypes are hyperkeratosis and parakeratosis

Wikipedia : 76 Infantile digital fibromatosis (also known as an "Inclusion body fibromatosis," "Infantile digital... more...

Related Diseases for Infantile Digital Fibromatosis

Diseases related to Infantile Digital Fibromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 fibromatosis 31.2 DES VIM
2 benign breast phyllodes tumor 10.2
3 diabetes mellitus, noninsulin-dependent 10.2
4 diabetes mellitus 10.2
5 hyperglycemia 10.2
6 terminal osseous dysplasia 10.0
7 herpes simplex 10.0
8 intermittent claudication 10.0
9 desmoplastic infantile ganglioglioma 10.0
10 heparin-induced thrombocytopenia 10.0
11 lymphangiomatosis 9.9 DES VIM
12 angiolipoma 9.9 DES VIM
13 primitive neuroectodermal tumor of the cervix uteri 9.9 DES VIM
14 cutaneous leiomyosarcoma 9.9 DES VIM
15 leiomyosarcoma 9.9 DES VIM
16 spindle cell lipoma 9.9 DES VIM
17 parachordoma 9.9 DES VIM
18 chordoma 9.9 DES VIM
19 epulis 9.9 DES VIM
20 syringocystadenoma papilliferum 9.9 DES VIM
21 ossifying fibromyxoid tumor 9.9 DES VIM
22 epithelioid leiomyosarcoma 9.9 DES VIM
23 benign metastasizing leiomyoma 9.9 DES VIM
24 leiomyoma 9.9 DES VIM
25 biphasic synovial sarcoma 9.9 DES VIM
26 syringoma 9.9 DES VIM
27 cystic nephroma 9.9 DES VIM
28 juvenile xanthogranuloma 9.9 DES VIM
29 pleomorphic liposarcoma 9.9 DES VIM
30 liposarcoma 9.9 DES VIM
31 desmoplastic small round cell tumor 9.9 DES VIM
32 perivascular epithelioid cell tumor 9.9 DES VIM
33 cutaneous fibrous histiocytoma 9.9 DES VIM
34 fibrous histiocytoma 9.9 DES VIM
35 congenital fibrosarcoma 9.9 DES VIM
36 fibrosarcoma 9.9 DES VIM
37 reticulum cell sarcoma 9.9 DES VIM
38 mesenchymal chondrosarcoma 9.9 DES VIM
39 extraskeletal ewing sarcoma 9.9 DES VIM
40 pseudosarcomatous fibromatosis 9.9 DES VIM
41 glomus tumor 9.9 DES VIM
42 spindle cell sarcoma 9.9 DES VIM
43 granular cell tumor 9.9 DES VIM
44 smooth muscle tumor 9.9 DES VIM
45 embryonal sarcoma 9.9 DES VIM
46 congenital epulis 9.9 DES VIM
47 hemangiopericytoma, malignant 9.9 DES VIM
48 infantile myofibromatosis 9.9 DES VIM
49 malignant fibroxanthoma 9.9 DES VIM
50 chondromyxoid fibroma 9.9 DES VIM

Graphical network of the top 20 diseases related to Infantile Digital Fibromatosis:



Diseases related to Infantile Digital Fibromatosis

Symptoms & Phenotypes for Infantile Digital Fibromatosis

Human phenotypes related to Infantile Digital Fibromatosis:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperkeratosis 59 32 frequent (33%) Frequent (79-30%) HP:0000962
2 parakeratosis 59 32 frequent (33%) Frequent (79-30%) HP:0001036
3 pain 59 32 very rare (1%) Very rare (<4-1%) HP:0012531
4 skin nodule 59 32 obligate (100%) Obligate (100%) HP:0200036
5 epidermal acanthosis 59 32 frequent (33%) Frequent (79-30%) HP:0025092

Drugs & Therapeutics for Infantile Digital Fibromatosis

Search Clinical Trials , NIH Clinical Center for Infantile Digital Fibromatosis

Genetic Tests for Infantile Digital Fibromatosis

Anatomical Context for Infantile Digital Fibromatosis

MalaCards organs/tissues related to Infantile Digital Fibromatosis:

41
Skin, Breast, Cervix, Smooth Muscle

Publications for Infantile Digital Fibromatosis

Articles related to Infantile Digital Fibromatosis:

(show top 50) (show all 58)
# Title Authors Year
1
Infantile digital fibromatosis-like tumor of adult. ( 29319280 )
2018
2
The Use of Cryotherapy to Treat Infantile Digital Fibromatosis with a Functional Deficit: A Case Report. ( 29734898 )
2018
3
An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report. ( 29780440 )
2018
4
Benign Nerve Sheath Myxoma in an Infant Misdiagnosed as Infantile Digital Fibromatosis. ( 27196676 )
2016
5
Infantile Digital Fibromatosis: A Rare Case Report. ( 27057032 )
2016
6
Case of infantile digital fibromatosis: Observation of its dermoscopic features. ( 27859517 )
2016
7
Infantile digital fibromatosis: a rare myofibrocytic tumor with characteristic histopathology. ( 25482706 )
2014
8
A case of infantile digital fibromatosis: differential diagnosis and treatment. ( 23330824 )
2014
9
Infantile digital fibromatosis. ( 23241193 )
2013
10
Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis. ( 24117680 )
2013
11
Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement. ( 23716832 )
2013
12
Diagnosis and treatment of digitocutaneous dysplasia, a rare infantile digital fibromatosis: a case report. ( 24426970 )
2013
13
Case report of an ulcerated infantile digital fibromatosis in an older child. The lump to spot in the child's hand (a spot not to lump in with the others). ( 23578982 )
2013
14
Infantile digital fibromatosis: a rare tumour of infancy. Report of five cases. ( 23157779 )
2012
15
Key cytological findings in FNA from infantile digital fibromatosis. ( 21986179 )
2011
16
Infantile digital fibromatosis: our experience and long-term results. ( 21276743 )
2011
17
Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. ( 20937573 )
2011
18
Congenital infantile digital fibromatosis: a case report and review of the literature. ( 21139926 )
2009
19
Infantile digital fibromatosis. ( 18571599 )
2008
20
Infantile digital fibromatosis. ( 18812724 )
2008
21
A range of histologic findings in infantile digital fibromatosis. ( 18304159 )
2008
22
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. ( 18266786 )
2008
23
An unusual congenital presentation of infantile digital fibromatosis. ( 17535189 )
2007
24
Infantile digital fibromatosis. ( 17273037 )
2007
25
Further documentation of spontaneous regression of infantile digital fibromatosis. ( 17542881 )
2007
26
Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome. ( 15864382 )
2005
27
Intralesional fluorouracil injection in infantile digital fibromatosis. ( 15897374 )
2005
28
Congenital infantile digital fibromatosis. ( 12220294 )
2002
29
A case of congenital infantile digital fibromatosis. ( 12383110 )
2002
30
Recurrent infantile digital fibromatosis--a rare entity. ( 11883128 )
2001
31
Infantile digital fibromatosis - a case report. ( 11164672 )
2001
32
Infantile digital fibromatosis: an unusual localization. ( 11584416 )
2001
33
A case of infantile digital fibromatosis with spontaneous regression. ( 9769598 )
1998
34
Recurring infantile digital fibromatosis: report of two cases. ( 7722838 )
1995
35
Infantile digital fibromatosis: a study of the development and regression of cytoplasmic inclusion bodies. ( 7675776 )
1995
36
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. ( 8172324 )
1994
37
Immunohistochemical identification of aggregated actin filaments in formalin-fixed, paraffin-embedded sections. I. A study of infantile digital fibromatosis by a new pretreatment. ( 1310240 )
1992
38
Infantile digital fibromatosis: ultrastructural human papillomavirus and herpes simplex virus DNA observation. ( 1656415 )
1991
39
SH abundant body in infantile digital fibromatosis--a histochemical study on distribution of sulfhydryl groups. ( 2177484 )
1990
40
Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. ( 1697612 )
1990
41
A case of infantile digital fibromatosis showing spontaneous regression. ( 2667619 )
1989
42
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions. ( 2827878 )
1988
43
Infantile digital fibromatosis-like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings. ( 2836293 )
1988
44
Posttraumatic occurrence of infantile digital fibromatosis. A histologic and electron microscopic study. ( 3740876 )
1986
45
Identification of actin microfilaments in the intracytoplasmic inclusions present in recurring infantile digital fibromatosis (Reye tumor). ( 3029741 )
1986
46
Infantile digital fibromatosis after web construction in syndactyly. ( 3020117 )
1986
47
Infantile digital fibromatosis. An electron microscopic and immunohistochemical study. ( 3811906 )
1986
48
Infantile digital fibromatosis occurring outside the digit. ( 6496846 )
1984
49
Infantile digital fibromatosis. ( 6545884 )
1984
50
Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding. ( 6311399 )
1983

Variations for Infantile Digital Fibromatosis

Expression for Infantile Digital Fibromatosis

Search GEO for disease gene expression data for Infantile Digital Fibromatosis.

Pathways for Infantile Digital Fibromatosis

Pathways related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 DES VIM
2 11.29 CNN1 DES VIM
3 11.01 DES VIM
4
Show member pathways
10.61 DES VIM

GO Terms for Infantile Digital Fibromatosis

Cellular components related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.96 DES VIM
2 cytoskeleton GO:0005856 8.8 CNN1 DES VIM

Biological processes related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.96 DES VIM
2 intermediate filament organization GO:0045109 8.62 DES VIM

Molecular functions related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 DES VIM

Sources for Infantile Digital Fibromatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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