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MCID: INF019
MIFTS: 31

Infectious Anterior Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Infectious Anterior Uveitis

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MalaCards integrated aliases for Infectious Anterior Uveitis:

Name: Infectious Anterior Uveitis 12 58 15
Secondary Infected Iridocyclitis 12 70
Secondary Iridocyclitis, Infectious 12
Infectious Secondary Iridocyclitis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9389
ICD9CM 34 364.03
SNOMED-CT 67 193487008
ICD10 32 H20.03
ICD10 via Orphanet 33 H20.0 H20.1 H20.2 more
Orphanet 58 ORPHA279922
UMLS 70 C0154911
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Summaries for Infectious Anterior Uveitis

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MalaCards based summary : Infectious Anterior Uveitis, also known as secondary infected iridocyclitis, is related to non-infectious anterior uveitis and uveitis. An important gene associated with Infectious Anterior Uveitis is HEXB (Hexosaminidase Subunit Beta), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Prednisolone acetate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Infectious Anterior Uveitis

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Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Infectious Posterior Uveitis Systemic Diseases with Anterior Uveitis
Systemic Diseases with Posterior Uveitis

Diseases related to Infectious Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 non-infectious anterior uveitis 11.3
2 uveitis 10.4
3 iridocyclitis 10.4
4 juvenile rheumatoid arthritis 10.1
5 barrett's adenocarcinoma 9.6 SOCS3 SOCS1
6 lymphadenitis 9.6 SOCS3 SOCS1
7 essential thrombocythemia 9.4 SOCS3 SOCS1
8 placental insufficiency 9.4 SOCS3 SOCS1 CISH
9 myeloproliferative neoplasm 9.4 SOCS3 SOCS1 CISH
10 body mass index quantitative trait locus 11 9.2 SOCS3 SOCS1 CISH

Graphical network of the top 20 diseases related to Infectious Anterior Uveitis:



Diseases related to Infectious Anterior Uveitis
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Symptoms & Phenotypes for Infectious Anterior Uveitis

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MGI Mouse Phenotypes related to Infectious Anterior Uveitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 CISH HEXB SOCS1 SOCS3 TRAF5
2 immune system MP:0005387 9.02 CISH HEXB SOCS1 SOCS3 TRAF5
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Drugs & Therapeutics for Infectious Anterior Uveitis

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Drugs for Infectious Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Neuroprotective Agents Phase 4
9 Anesthetics Phase 4
10 Methylprednisolone Acetate Phase 4
11 Ophthalmic Solutions Phase 4
12 BB 1101 Phase 4
13 Protective Agents Phase 4
14
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
15
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
16 Pharmaceutical Solutions Phase 3
17 Gastrointestinal Agents Phase 2, Phase 3
18 Antiemetics Phase 2, Phase 3
19 glucocorticoids Phase 2, Phase 3
20 Hormone Antagonists Phase 2, Phase 3
21 Hormones Phase 2, Phase 3
22 Antineoplastic Agents, Hormonal Phase 2, Phase 3
23 Anti-Inflammatory Agents Phase 2, Phase 3
24 Dexamethasone 21-phosphate Phase 1, Phase 2
25
protease inhibitors Phase 1, Phase 2
26 HIV Protease Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of DEXTENZA on the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids Not yet recruiting NCT04426734 Phase 4 Topical Prednisolone Acetate 1%
2 A Phase 3, Randomized, Double-masked, Vehicle-controlled Trial to Evaluate the Safety and Efficacy of ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Completed NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
3 A Double-Masked, Placebo-Controlled, Parallel-Group, Multi-Center, Dose-Ranging Study With an Optional Extension to Assess the Efficacy and Safety of LX211 as Therapy in Subjects With Active Sight Threatening, Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
4 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
5 A Randomized, Parallel Group, Double-masked, Active-controlled Phase 1/2 Clinical Trial to Evaluate the Efficacy and Safety of Dexamethasone Sodium Phosphate Visulex System for the Treatment of Non-infectious Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
6 A Phase 2 Randomized, Investigator-Masked, Comparator-controlled Trial to Evaluate the Safety and Efficacy of NS2 Eye Drops in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
7 A Randomized, Double-Masked, Dose-Ranging Study to Evaluate the Safety and Tolerability of TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis. Completed NCT04222712 Phase 1, Phase 2 TRS01 eye drops;TRS01 eye drops

Search NIH Clinical Center for Infectious Anterior Uveitis

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Genetic Tests for Infectious Anterior Uveitis

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Anatomical Context for Infectious Anterior Uveitis

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MalaCards organs/tissues related to Infectious Anterior Uveitis:

40
Eye
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Publications for Infectious Anterior Uveitis

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Articles related to Infectious Anterior Uveitis:

(show all 17)
# Title Authors PMID Year
1
Epidemiology of Viral Induced Anterior Uveitis. 61
33617392 2021
2
A review of the clinical applications of drug delivery systems for the treatment of ocular anterior segment inflammation. 61
33127826 2020
3
Serum Immunoglobulin Levels, Complement Components 3 and 4, HLA-B27 Allele and Spondyloarthropathy in Patients with Non-Infectious Anterior Uveites. 61
32891541 2020
4
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis. 61
30487588 2019
5
Efficacy of anti-tumour necrosis factor-α monoclonal antibodies in patients with non-infectious anterior uveitis. 61
30719968 2019
6
Superficial and deep retinal foveal avascular zone OCTA findings of non-infectious anterior and posterior uveitis. 61
29980918 2018
7
Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. 61
30327966 2018
8
[Therapeutic strategy for the treatment of non-infectious uveitis proposed by an expert panel]. 61
29610003 2018
9
The pathogenic role of dendritic cells in non-infectious anterior uveitis. 61
29763582 2018
10
Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis. 61
29700320 2018
11
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. 61
29345511 2018
12
Treatment recommendations for non-infectious anterior uveitis. 61
28911893 2017
13
Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis. 61
26708737 2016
14
Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infection. 61
24993154 2015
15
[Ocular hypertension in herpes simplex keratouveitis]. 61
25842621 2014
16
The diagnostic utility of anterior chamber paracentesis with polymerase chain reaction in anterior uveitis. 61
23415597 2013
17
Current diagnostic approaches to infectious anterior uveitis. 61
21897147 2011
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Variations for Infectious Anterior Uveitis

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Expression for Infectious Anterior Uveitis

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Search GEO for disease gene expression data for Infectious Anterior Uveitis.
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Pathways for Infectious Anterior Uveitis

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Pathways related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.77 SOCS3 SOCS1 CISH
2
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 64
Show member pathways
 12.36 SOCS3 SOCS1 CISH
3
Prolactin Signaling Pathway 1 36
Show member pathways
 12.08 SOCS3 SOCS1 CISH
4
JAK-STAT signaling pathway 36
Show member pathways
 11.98 SOCS3 SOCS1 CISH
5
NF-kappaB Signaling 4
11.97 TRAF5 SOCS3 SOCS1 CISH
6
Ubiquitin mediated proteolysis 36
11.74 SOCS3 SOCS1
7
Adipogenesis 1
11.7 SOCS3 SOCS1
8
Osteoclast differentiation 36
11.68 SOCS3 SOCS1
9
IL-2 Signaling Pathway 1
Show member pathways
 11.67 SOCS3 SOCS1 CISH
10
Interleukin-4 and 13 signaling 65
11.62 SOCS3 SOCS1
11
TNF signaling pathway 36
11.61 TRAF5 SOCS3
12
Type II diabetes mellitus 1 36
Show member pathways
 11.53 SOCS3 SOCS1
13
Visual Cycle in Retinal Rods 63
11.47 SOCS3 SOCS1 CISH
14
Development EPO-induced Jak-STAT pathway 23
Show member pathways
 11.42 SOCS3 SOCS1 CISH
15
IL4-mediated signaling events 1
11.32 SOCS3 SOCS1
16
Interferon type I signaling pathways 1
11.24 SOCS3 SOCS1
17
Immune response IL-2 activation and signaling pathway 23
Show member pathways
 11.16 SOCS3 SOCS1 CISH
18
Type II interferon signaling (IFNG) 1
11.05 SOCS3 SOCS1
19
IL10 Signaling Pathway 66
10.9 SOCS3 SOCS1
20
Telomere Extension by Telomerase 63
Show member pathways
 10.86 SOCS3 CISH
21
Growth hormone receptor signaling 65
Show member pathways
 10.41 SOCS3 SOCS1 CISH
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GO Terms for Infectious Anterior Uveitis

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Cellular components related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.8 SOCS3 SOCS1 CISH

Biological processes related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein ubiquitination GO:0016567 9.71 SOCS3 SOCS1 CISH
2 intracellular signal transduction GO:0035556 9.67 SOCS3 SOCS1 CISH
3 negative regulation of protein kinase activity GO:0006469 9.52 SOCS3 SOCS1
4 regulation of protein phosphorylation GO:0001932 9.51 SOCS3 SOCS1
5 negative regulation of insulin receptor signaling pathway GO:0046627 9.48 SOCS3 SOCS1
6 JAK-STAT cascade GO:0007259 9.46 SOCS3 SOCS1
7 interleukin-7-mediated signaling pathway GO:0038111 9.43 SOCS1 CISH
8 regulation of growth GO:0040008 9.43 SOCS3 SOCS1 CISH
9 negative regulation of JAK-STAT cascade GO:0046426 9.4 SOCS3 SOCS1
10 negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 9.37 SOCS3 SOCS1
11 negative regulation of signal transduction GO:0009968 9.33 SOCS3 SOCS1 CISH
12 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.32 SOCS3 SOCS1
13 phosphatidylinositol phosphorylation GO:0046854 9.13 SOCS3 SOCS1 CISH
14 regulation of phosphatidylinositol 3-kinase activity GO:0043551 8.8 SOCS3 SOCS1 CISH

Molecular functions related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase inhibitor activity GO:0004860 8.96 SOCS3 SOCS1
2 1-phosphatidylinositol-3-kinase regulator activity GO:0046935 8.8 SOCS3 SOCS1 CISH
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Sources for Infectious Anterior Uveitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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