Infectious Anterior Uveitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INF019 MIFTS: 34	Infectious Anterior Uveitis Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Infectious Anterior Uveitis

MalaCards integrated aliases for Infectious Anterior Uveitis:

Name: Infectious Anterior Uveitis ¹² ⁵⁹ ¹⁵

Secondary Infected Iridocyclitis ¹² ⁷³

Secondary Iridocyclitis, Infectious ¹²

Infectious Secondary Iridocyclitis ¹²

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of sclera, cornea, iris and ciliary body

Iridocyclitis

Acute and subacute iridocyclitis

Chronic iridocyclitis

Iridocyclitis, unspecified

Lens-induced iridocyclitis

Other iridocyclitis

Orphanet: ⁵⁹

Rare eye diseases

External Ids:

Disease Ontology ¹² DOID:9389

ICD10 ³³ H20.03

ICD9CM ³⁵ 364.03

SNOMED-CT ⁶⁸ 89114005

Orphanet ⁵⁹ ORPHA279922

ICD10 via Orphanet ³⁴ H20.0 H20.1 H20.2 more

UMLS ⁷³ C0154911

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Summaries for Infectious Anterior Uveitis

MalaCards based summary : Infectious Anterior Uveitis, also known as secondary infected iridocyclitis, is related to uveitis and anterior uveitis. An important gene associated with Infectious Anterior Uveitis is SOCS1 (Suppressor Of Cytokine Signaling 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Regulation of lipid metabolism Insulin signaling-generic cascades. Affiliated tissues include eye.

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Related Diseases for Infectious Anterior Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis	Posterior Uveitis
Intermediate Uveitis	Infectious Anterior Uveitis
Anterior Uveitis	Infectious Posterior Uveitis

Diseases related to Infectious Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	uveitis	10.3
2	anterior uveitis	10.3
3	zika fever	9.8	MRAP STAT1
4	ochronosis	9.7	MRAP SAA1

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Symptoms & Phenotypes for Infectious Anterior Uveitis

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Drugs & Therapeutics for Infectious Anterior Uveitis

Search Clinical Trials , NIH Clinical Center for Infectious Anterior Uveitis

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Genetic Tests for Infectious Anterior Uveitis

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Anatomical Context for Infectious Anterior Uveitis

MalaCards organs/tissues related to Infectious Anterior Uveitis:

⁴¹

Eye

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Publications for Infectious Anterior Uveitis

Articles related to Infectious Anterior Uveitis:

#	Title	Authors	Year
1	The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )	O'Rourke M....Canavan M.	2018
2	Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. ( 30327966 )	Angeles-Han ST...Holland GN	2018
3	Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis. ( 30487588 )	McCracken C...Angeles-Han ST	2018
4	Document of treatment recommendations for non-infectious anterior uveitis. ( 28911893 )	Espinosa G....Cordero-Coma M.	2017
5	Current diagnostic approaches to infectious anterior uveitis. ( 21897147 )		2011

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Genes for Infectious Anterior Uveitis

Genes related to Infectious Anterior Uveitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	14.78	DISEASES inferred ¹⁵
2	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	14.59	DISEASES inferred ¹⁵
3	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	14.2	DISEASES inferred ¹⁵
4	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	14.04	DISEASES inferred ¹⁵
5	SAA1	Serum Amyloid A1	Protein Coding	13.22	DISEASES inferred ¹⁵
6	SEMA3G	Semaphorin 3G	Protein Coding	4.51	DISEASES inferred ¹⁵

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Variations for Infectious Anterior Uveitis

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Expression for Infectious Anterior Uveitis

Search GEO for disease gene expression data for Infectious Anterior Uveitis.

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Pathways for Infectious Anterior Uveitis

Pathways related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 32)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.02	SAA1 SOCS1 SOCS3 STAT1
2	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁷ IRS activation ⁶⁶ Signal attenuation ⁶⁶ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	12.59	SOCS1 SOCS3 STAT1
3	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ IL-9 Signaling Pathways ⁶⁵ Immune response IL-9 signaling pathway ²²	12.48	SOCS1 SOCS3 STAT1
4	NF-kappaB Signaling ⁴	12.27	SOCS1 SOCS3 STAT1
5	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.24	SOCS1 SOCS3 STAT1
6	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.19	SOCS1 SOCS3 STAT1
7	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.11	SOCS1 SOCS3 STAT1
8	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.11	SOCS1 SOCS3 STAT1
9	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	11.98	SOCS1 SOCS3 STAT1
10	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	11.81	SOCS1 SOCS3 STAT1
11	Ubiquitin mediated proteolysis ³⁷	11.79	SOCS1 SOCS3
12	Adipogenesis ¹	11.79	SOCS1 SOCS3 STAT1
13	Hepatitis C ³⁷	11.77	SOCS3 STAT1
14	Osteoclast differentiation ³⁷	11.76	SOCS1 SOCS3 STAT1
15	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.7	SOCS1 STAT1
16	Immune response IL-2 activation and signaling pathway ²² Show member pathways Immune response IL-3 activation and signaling pathway ²²	11.67	SOCS1 SOCS3
17	Type II diabetes mellitus ³⁷ ¹ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶¹	11.62	SOCS1 SOCS3
18	Jak-Stat Signaling Pathway (sino) ⁶⁷	11.58	SOCS1 SOCS3 STAT1
19	IL6-mediated signaling events ¹ Show member pathways IL-6 signaling pathway ¹	11.56	SOCS3 STAT1
20	Visual Cycle in Retinal Rods ⁶⁴	11.55	SOCS1 SOCS3 STAT1
21	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.53	SOCS1 SOCS3 STAT1
22	IL4-mediated signaling events ¹	11.42	SOCS1 SOCS3
23	Interleukin-6 family signaling ⁶⁶ Show member pathways IL-6-type cytokine receptor ligand interactions ⁶⁶ Interleukin-6 signaling ⁶⁶	11.37	SOCS3 STAT1
24	Interferon type I signaling pathways ¹	11.24	SOCS1 SOCS3 STAT1
25	Interleukin-11 Signaling Pathway ¹	11.23	SOCS3 STAT1
26	Growth hormone receptor signaling ⁶⁶ Show member pathways Prolactin receptor signaling ⁶⁶	11.05	SOCS1 SOCS3 STAT1
27	Interleukin-4 and 13 signaling ⁶⁶	10.98	SAA1 SOCS1 SOCS3 STAT1
28	Development_Thrombopoetin signaling via JAK-STAT pathway ²²	10.97	SOCS1 SOCS3 STAT1
29	Jak/STAT Signaling Pathway Intracellular Regulation ⁶⁵	10.93	SOCS1 SOCS3 STAT1
30	Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶¹ Show member pathways Inhibition of PKR ⁶⁶	10.9	SOCS3 STAT1
31	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²²	10.8	SOCS3 STAT1
32	Type II interferon signaling (IFNG) ¹	10.7	SOCS1 SOCS3 STAT1

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GO Terms for Infectious Anterior Uveitis

Cellular components related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol 3-kinase complex	GO:0005942	8.62	SOCS1 SOCS3

Biological processes related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of signal transduction	GO:0009968	9.54	SOCS1 SOCS3
2	phosphatidylinositol phosphorylation	GO:0046854	9.52	SOCS1 SOCS3
3	negative regulation of inflammatory response	GO:0050728	9.51	SAA1 SOCS3
4	negative regulation of protein kinase activity	GO:0006469	9.49	SOCS1 SOCS3
5	regulation of growth	GO:0040008	9.48	SOCS1 SOCS3
6	regulation of protein phosphorylation	GO:0001932	9.46	SOCS1 SOCS3
7	cytokine-mediated signaling pathway	GO:0019221	9.46	SAA1 SOCS1 SOCS3 STAT1
8	negative regulation of insulin receptor signaling pathway	GO:0046627	9.43	SOCS1 SOCS3
9	regulation of phosphatidylinositol 3-kinase activity	GO:0043551	9.4	SOCS1 SOCS3
10	interleukin-6-mediated signaling pathway	GO:0070102	9.37	SOCS3 STAT1
11	negative regulation of JAK-STAT cascade	GO:0046426	9.32	SOCS1 SOCS3
12	negative regulation of tyrosine phosphorylation of STAT protein	GO:0042532	9.26	SOCS1 SOCS3
13	JAK-STAT cascade	GO:0007259	9.13	SOCS1 SOCS3 STAT1
14	regulation of interferon-gamma-mediated signaling pathway	GO:0060334	8.8	SOCS1 SOCS3 STAT1

Molecular functions related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase inhibitor activity	GO:0004860	8.96	SOCS1 SOCS3
2	1-phosphatidylinositol-3-kinase regulator activity	GO:0046935	8.62	SOCS1 SOCS3

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Sources for Infectious Anterior Uveitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia