Infectious Anterior Uveitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INF019 MIFTS: 26	Infectious Anterior Uveitis Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Download Expand all tables

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Aliases & Classifications for Infectious Anterior Uveitis

MalaCards integrated aliases for Infectious Anterior Uveitis:

Name: Infectious Anterior Uveitis ¹² ⁵⁹ ¹⁵

Secondary Infected Iridocyclitis ¹² ⁷³

Secondary Iridocyclitis, Infectious ¹²

Infectious Secondary Iridocyclitis ¹²

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of sclera, cornea, iris and ciliary body

Iridocyclitis

Acute and subacute iridocyclitis

Chronic iridocyclitis

Iridocyclitis, unspecified

Lens-induced iridocyclitis

Other iridocyclitis

Orphanet: ⁵⁹

Rare eye diseases

External Ids:

Disease Ontology ¹² DOID:9389

ICD10 ³³ H20.03

ICD9CM ³⁵ 364.03

SNOMED-CT ⁶⁸ 193487008 89114005

Orphanet ⁵⁹ ORPHA279922

ICD10 via Orphanet ³⁴ H20.0 H20.1 H20.2 more

UMLS ⁷³ C0154911

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Summaries for Infectious Anterior Uveitis

MalaCards based summary : Infectious Anterior Uveitis, also known as secondary infected iridocyclitis, is related to uveitis and anterior uveitis. An important gene associated with Infectious Anterior Uveitis is SOCS1 (Suppressor Of Cytokine Signaling 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Regulation of lipid metabolism Insulin signaling-generic cascades. Affiliated tissues include eye.

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Related Diseases for Infectious Anterior Uveitis

Diseases in the Uveitis family:

Posterior Uveitis	Intermediate Uveitis
Infectious Anterior Uveitis	Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Infectious Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	uveitis	10.0
2	anterior uveitis	10.0
3	hepatitis c	8.9	SOCS3 STAT1

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Symptoms & Phenotypes for Infectious Anterior Uveitis

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Drugs & Therapeutics for Infectious Anterior Uveitis

Search Clinical Trials , NIH Clinical Center for Infectious Anterior Uveitis

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Genetic Tests for Infectious Anterior Uveitis

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Anatomical Context for Infectious Anterior Uveitis

MalaCards organs/tissues related to Infectious Anterior Uveitis:

⁴¹

Eye

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Publications for Infectious Anterior Uveitis

Articles related to Infectious Anterior Uveitis:

#	Title	Authors	Year
1	The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )	O'Rourke M....Canavan M.	2018
2	Document of treatment recommendations for non-infectious anterior uveitis. ( 28911893 )	Espinosa G....Cordero-Coma M.	2017
3	Current diagnostic approaches to infectious anterior uveitis. ( 21897147 )	Hunter R.S....Lobo A.M.	2011

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Genes for Infectious Anterior Uveitis

Genes related to Infectious Anterior Uveitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	14.78	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	14.42	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	14.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Infectious Anterior Uveitis

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Expression for Infectious Anterior Uveitis

Search GEO for disease gene expression data for Infectious Anterior Uveitis.

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Pathways for Infectious Anterior Uveitis

Pathways related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 34)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.95	SOCS1 SOCS3 STAT1
2	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁷ IRS activation ⁶⁶ Signal attenuation ⁶⁶ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	12.55	SOCS1 SOCS3 STAT1
3	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Signaling Pathway ¹ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ IL-9 Signaling Pathways ⁶⁵ Immune response IL-4 signaling pathway ²² Immune response IL-9 signaling pathway ²²	12.55	SOCS1 SOCS3 STAT1
4	ErbB4 Pathway ⁶⁴ Show member pathways ErbB Family Pathway ⁶⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ Growth Hormone Signaling ⁶⁴ IL-4 Pathway ⁶⁴ Prolactin Signaling ⁶⁴ Thrombopoietin Pathway ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	12.45	SOCS1 SOCS3 STAT1
5	Regulation of IFNA signaling ⁶⁶ Show member pathways Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Jak-STAT signaling pathway ³⁷	12.32	SOCS1 SOCS3 STAT1
6	NF-kappaB Signaling ⁴	12.26	SOCS1 SOCS3 STAT1
7	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.23	SOCS1 SOCS3 STAT1
8	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.16	SOCS1 SOCS3 STAT1
9	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ IL-6-type cytokine receptor ligand interactions ⁶⁶ Interleukin-6 family signaling ⁶⁶ Interleukin-6 signaling ⁶⁶ Th17 Differentiation Pathway ⁶⁵	11.93	SOCS3 STAT1
10	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	11.93	SOCS1 STAT1
11	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	11.9	SOCS3 STAT1
12	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	11.86	SOCS1 STAT1
13	Immune response Antigen presentation by MHC class II ²² Show member pathways G-protein signaling N-RAS regulation pathway ²² IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²²	11.86	SOCS3 STAT1
14	Ubiquitin mediated proteolysis ³⁷	11.78	SOCS1 SOCS3
15	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	11.78	SOCS1 SOCS3 STAT1
16	Hepatitis C ³⁷	11.75	SOCS3 STAT1
17	Adipogenesis ¹	11.75	SOCS1 SOCS3 STAT1
18	Osteoclast differentiation ³⁷	11.72	SOCS1 SOCS3 STAT1
19	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.68	SOCS1 STAT1
20	Immune response IL-2 activation and signaling pathway ²² Show member pathways Immune response IL-3 activation and signaling pathway ²²	11.66	SOCS1 SOCS3
21	Jak-Stat Signaling Pathway ⁶⁷	11.62	SOCS1 SOCS3 STAT1
22	Type II diabetes mellitus ³⁷ ¹ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶¹	11.6	SOCS1 SOCS3
23	Interleukin-4 and 13 signaling ⁶⁶	11.6	SOCS1 SOCS3 STAT1
24	IL6-mediated signaling events ¹ Show member pathways IL-6 signaling pathway ¹	11.55	SOCS3 STAT1
25	Visual Cycle in Retinal Rods ⁶⁴	11.55	SOCS1 SOCS3 STAT1
26	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.48	SOCS1 SOCS3 STAT1
27	IL4-mediated signaling events ¹	11.39	SOCS1 SOCS3
28	Interleukin-11 Signaling Pathway ¹	11.22	SOCS3 STAT1
29	Interferon type I signaling pathways ¹	11.17	SOCS1 SOCS3 STAT1
30	Growth hormone receptor signaling ⁶⁶ Show member pathways Prolactin receptor signaling ⁶⁶	10.94	SOCS1 SOCS3 STAT1
31	Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶¹ Show member pathways Inhibition of PKR ⁶⁶	10.89	SOCS3 STAT1
32	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²²	10.79	SOCS3 STAT1
33	Jak/STAT Signaling Pathway Intracellular Regulation ⁶⁵	10.73	SOCS1 SOCS3 STAT1
34	Type II interferon signaling (IFNG) ¹	10.37	SOCS1 SOCS3 STAT1

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GO Terms for Infectious Anterior Uveitis

Biological processes related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.5	SOCS1 SOCS3 STAT1
2	negative regulation of signal transduction	GO:0009968	9.49	SOCS1 SOCS3
3	negative regulation of protein kinase activity	GO:0006469	9.48	SOCS1 SOCS3
4	regulation of growth	GO:0040008	9.46	SOCS1 SOCS3
5	regulation of protein phosphorylation	GO:0001932	9.43	SOCS1 SOCS3
6	negative regulation of JAK-STAT cascade	GO:0046426	9.4	SOCS1 SOCS3
7	negative regulation of insulin receptor signaling pathway	GO:0046627	9.37	SOCS1 SOCS3
8	JAK-STAT cascade	GO:0007259	9.26	SOCS3 STAT1
9	interleukin-6-mediated signaling pathway	GO:0070102	9.16	SOCS3 STAT1
10	negative regulation of tyrosine phosphorylation of STAT protein	GO:0042532	8.96	SOCS1 SOCS3
11	regulation of interferon-gamma-mediated signaling pathway	GO:0060334	8.8	SOCS1 SOCS3 STAT1

Molecular functions related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase inhibitor activity	GO:0004860	8.62	SOCS1 SOCS3

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Sources for Infectious Anterior Uveitis

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