MCID: INF019
MIFTS: 34

Infectious Anterior Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Infectious Anterior Uveitis

MalaCards integrated aliases for Infectious Anterior Uveitis:

Name: Infectious Anterior Uveitis 12 59 15
Secondary Infected Iridocyclitis 12 73
Secondary Iridocyclitis, Infectious 12
Infectious Secondary Iridocyclitis 12

Classifications:

Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9389
ICD10 33 H20.03
ICD9CM 35 364.03
SNOMED-CT 68 89114005
Orphanet 59 ORPHA279922
ICD10 via Orphanet 34 H20.0 H20.1 H20.2 more
UMLS 73 C0154911

Summaries for Infectious Anterior Uveitis

MalaCards based summary : Infectious Anterior Uveitis, also known as secondary infected iridocyclitis, is related to uveitis and anterior uveitis. An important gene associated with Infectious Anterior Uveitis is SOCS1 (Suppressor Of Cytokine Signaling 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Regulation of lipid metabolism Insulin signaling-generic cascades. Affiliated tissues include eye.

Related Diseases for Infectious Anterior Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Infectious Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 uveitis 10.3
2 anterior uveitis 10.3
3 zika fever 9.8 MRAP STAT1
4 ochronosis 9.7 MRAP SAA1

Symptoms & Phenotypes for Infectious Anterior Uveitis

Drugs & Therapeutics for Infectious Anterior Uveitis

Search Clinical Trials , NIH Clinical Center for Infectious Anterior Uveitis

Genetic Tests for Infectious Anterior Uveitis

Anatomical Context for Infectious Anterior Uveitis

MalaCards organs/tissues related to Infectious Anterior Uveitis:

41
Eye

Publications for Infectious Anterior Uveitis

Articles related to Infectious Anterior Uveitis:

# Title Authors Year
1
The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )
2018
2
Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. ( 30327966 )
2018
3
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis. ( 30487588 )
2018
4
Document of treatment recommendations for non-infectious anterior uveitis. ( 28911893 )
2017
5
Current diagnostic approaches to infectious anterior uveitis. ( 21897147 )
2011

Variations for Infectious Anterior Uveitis

Expression for Infectious Anterior Uveitis

Search GEO for disease gene expression data for Infectious Anterior Uveitis.

Pathways for Infectious Anterior Uveitis

Pathways related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 SAA1 SOCS1 SOCS3 STAT1
2
Show member pathways
12.59 SOCS1 SOCS3 STAT1
3
Show member pathways
12.48 SOCS1 SOCS3 STAT1
4 12.27 SOCS1 SOCS3 STAT1
5
Show member pathways
12.24 SOCS1 SOCS3 STAT1
6
Show member pathways
12.19 SOCS1 SOCS3 STAT1
7
Show member pathways
12.11 SOCS1 SOCS3 STAT1
8
Show member pathways
12.11 SOCS1 SOCS3 STAT1
9
Show member pathways
11.98 SOCS1 SOCS3 STAT1
10
Show member pathways
11.81 SOCS1 SOCS3 STAT1
11 11.79 SOCS1 SOCS3
12 11.79 SOCS1 SOCS3 STAT1
13 11.77 SOCS3 STAT1
14 11.76 SOCS1 SOCS3 STAT1
15
Show member pathways
11.7 SOCS1 STAT1
16
Show member pathways
11.67 SOCS1 SOCS3
17
Show member pathways
11.62 SOCS1 SOCS3
18 11.58 SOCS1 SOCS3 STAT1
19
Show member pathways
11.56 SOCS3 STAT1
20 11.55 SOCS1 SOCS3 STAT1
21
Show member pathways
11.53 SOCS1 SOCS3 STAT1
22 11.42 SOCS1 SOCS3
23
Show member pathways
11.37 SOCS3 STAT1
24 11.24 SOCS1 SOCS3 STAT1
25 11.23 SOCS3 STAT1
26
Show member pathways
11.05 SOCS1 SOCS3 STAT1
27 10.98 SAA1 SOCS1 SOCS3 STAT1
28 10.97 SOCS1 SOCS3 STAT1
29 10.93 SOCS1 SOCS3 STAT1
30
Show member pathways
10.9 SOCS3 STAT1
31 10.8 SOCS3 STAT1
32 10.7 SOCS1 SOCS3 STAT1

GO Terms for Infectious Anterior Uveitis

Cellular components related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.62 SOCS1 SOCS3

Biological processes related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of signal transduction GO:0009968 9.54 SOCS1 SOCS3
2 phosphatidylinositol phosphorylation GO:0046854 9.52 SOCS1 SOCS3
3 negative regulation of inflammatory response GO:0050728 9.51 SAA1 SOCS3
4 negative regulation of protein kinase activity GO:0006469 9.49 SOCS1 SOCS3
5 regulation of growth GO:0040008 9.48 SOCS1 SOCS3
6 regulation of protein phosphorylation GO:0001932 9.46 SOCS1 SOCS3
7 cytokine-mediated signaling pathway GO:0019221 9.46 SAA1 SOCS1 SOCS3 STAT1
8 negative regulation of insulin receptor signaling pathway GO:0046627 9.43 SOCS1 SOCS3
9 regulation of phosphatidylinositol 3-kinase activity GO:0043551 9.4 SOCS1 SOCS3
10 interleukin-6-mediated signaling pathway GO:0070102 9.37 SOCS3 STAT1
11 negative regulation of JAK-STAT cascade GO:0046426 9.32 SOCS1 SOCS3
12 negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 9.26 SOCS1 SOCS3
13 JAK-STAT cascade GO:0007259 9.13 SOCS1 SOCS3 STAT1
14 regulation of interferon-gamma-mediated signaling pathway GO:0060334 8.8 SOCS1 SOCS3 STAT1

Molecular functions related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase inhibitor activity GO:0004860 8.96 SOCS1 SOCS3
2 1-phosphatidylinositol-3-kinase regulator activity GO:0046935 8.62 SOCS1 SOCS3

Sources for Infectious Anterior Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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