MCID: INF034
MIFTS: 56

Infective Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Infective Endocarditis

MalaCards integrated aliases for Infective Endocarditis:

Name: Infective Endocarditis 12 76 53 15 73
Endocarditis, Infective 76 53
Endocarditis Infective 55
Bacterial Endocarditis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060000

Summaries for Infective Endocarditis

NIH Rare Diseases : 53 Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. IE is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damage the heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.

MalaCards based summary : Infective Endocarditis, also known as endocarditis, infective, is related to endocarditis and heart disease, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and TRAF Pathway. The drugs Lidocaine and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia : 76 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Infective Endocarditis

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 388)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.5 APOH AQP9 CRP F2 FCGR2A IL6
2 heart disease 30.2 CRP F2 IL6 SERPINE1 TNF TNNI3
3 pericarditis 30.1 CRP IL6 TNF
4 acute myocardial infarction 30.0 CRP SERPINE1 TNNI3
5 kawasaki disease 29.9 CRP FCGR2A IL6 TNF
6 bursitis 29.8 CRP SH3BP5
7 stroke, ischemic 29.8 APOH CRP F2 SERPINE1
8 vasculitis 29.8 APOH CRP TNF
9 meningitis 29.8 CRP FCGR2A IL6 TLR2 TNF
10 end stage renal failure 29.8 CRP IL6 TNF
11 haemophilus influenzae 29.7 TLR2 TNF
12 myocarditis 29.7 IL6 TNF TNNI3
13 pulmonary embolism 29.6 APOH CRP F2 SERPINE1 TNNI3
14 pneumonia 29.6 CRP IL6 TLR2 TNF
15 pyelonephritis 29.6 CRP IL6 TNF
16 brucellosis 29.6 CRP IL6 TNF
17 streptococcal toxic-shock syndrome 29.6 IL6 TNF
18 limb ischemia 29.6 IL6 TNF TNNI3
19 spondylitis 29.6 CRP IL6 TNF
20 cardiogenic shock 29.5 IL6 TNF
21 retinal artery occlusion 29.5 APOH F2 IL6 SERPINE1
22 echinococcosis 29.5 IL6 TLR2 TNF
23 peritonitis 29.5 CRP F2 IL6 LBP TLR2 TNF
24 toxic shock syndrome 29.5 IL6 TLR2 TNF
25 thrombosis 29.4 APOH F2 GP1BA SERPINE1
26 takayasu arteritis 29.4 CRP FCGR2A IL6 TNF
27 thrombocytopenia 29.4 APOH GP1BA ITGB3
28 temporal arteritis 29.4 APOH CRP IL6 TNF
29 periodontitis 29.4 CRP IL6 TLR2 TNF
30 periodontal disease 29.4 CRP IL6 TLR2 TNF
31 myocardial infarction 29.3 CRP F2 GP1BA IL6 ITGB3 SERPINE1
32 arteriovenous fistula 29.3 APOH IL6
33 psoriatic arthritis 29.2 CRP IL6 TNF
34 intermittent claudication 29.1 APOH CRP F2 IL6 SERPINE1
35 purpura 29.1 APOH CRP F2 IL6 ITGB3 TNF
36 sudden sensorineural hearing loss 29.1 APOH F2 IL6 ITGB3
37 systemic lupus erythematosus 28.9 APOH CRP F2 FCGR2A IL6 TLR2
38 orthostatic intolerance 11.5
39 marantic endocarditis 11.5
40 subacute bacterial endocarditis 11.0
41 ischemic neuropathy 10.3 CRP F2
42 ventricular septal defect 10.3
43 rheumatic myocarditis 10.3 CRP TNNI3
44 subendocardial myocardial infarction 10.3 F2 SERPINE1
45 cryptogenic cirrhosis 10.3 F2 SERPINE1
46 neutrophilia, hereditary 10.3 CRP IL6
47 spinal disease 10.3 CRP IL6
48 malignant otitis externa 10.3 CRP F2
49 uremic pruritus 10.3 CRP IL6
50 aortic valve disease 1 10.3

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to Infective Endocarditis

Symptoms & Phenotypes for Infective Endocarditis

UMLS symptoms related to Infective Endocarditis:


osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 AQP9 F2 FCGR2A GP1BA IL6 ITGB3
2 homeostasis/metabolism MP:0005376 10 APOH AQP9 CRP F2 GP1BA IL6
3 cardiovascular system MP:0005385 9.97 CRP F2 IL6 ITGB3 SERPINE1 TLR2
4 immune system MP:0005387 9.85 AQP9 CRP F2 FCGR2A IL6 ITGB3
5 liver/biliary system MP:0005370 9.43 IL6 ITGB3 LBP SERPINE1 TLR2 TNF
6 respiratory system MP:0005388 9.17 F2 IL6 ITGB3 SERPINE1 TLR2 TNF

Drugs & Therapeutics for Infective Endocarditis

Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
2
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 14969 441141
3
Fosfomycin Approved Phase 4 23155-02-4 446987
4
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
5
Hexetidine Approved, Investigational Phase 4 141-94-6
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Racepinephrine Approved Phase 4 329-65-7 838
8
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
9
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
10
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
11
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
12 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Anesthetics Phase 4,Phase 2,Not Applicable
16 Anti-Arrhythmia Agents Phase 4,Phase 2
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Anesthetics, Local Phase 4,Phase 2
19 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
20 Diuretics, Potassium Sparing Phase 4,Phase 2
21 Sodium Channel Blockers Phase 4,Phase 2
22 beta-Lactams Phase 4
23 Lactams Phase 4
24 methicillin Phase 4,Phase 3,Phase 2
25 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Vasoconstrictor Agents Phase 4
27 Pharmaceutical Solutions Phase 4
28 Adrenergic alpha-Agonists Phase 4,Not Applicable
29 Adrenergic beta-Agonists Phase 4
30 Chlorhexidine gluconate Phase 4,Not Applicable
31 Anti-Asthmatic Agents Phase 4
32 Disinfectants Phase 4,Not Applicable
33 Adrenergic Agents Phase 4,Not Applicable
34 Mydriatics Phase 4
35 Autonomic Agents Phase 4,Phase 3
36 Epinephryl borate Phase 4
37 Neurotransmitter Agents Phase 4,Not Applicable
38 Adrenergic Agonists Phase 4,Not Applicable
39 Respiratory System Agents Phase 4
40 Anti-Infective Agents, Local Phase 4,Not Applicable
41 Bronchodilator Agents Phase 4
42 Dermatologic Agents Phase 4,Not Applicable
43 Sympathomimetics Phase 4
44 beta-Lactamase Inhibitors Phase 4
45 Clavulanic Acids Phase 4
46 Amoxicillin-Potassium Clavulanate Combination Phase 4
47 Gentamicins Phase 4,Phase 3,Not Applicable
48
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
49
Ceftriaxone Approved Phase 3,Phase 2 73384-59-5 5479530 5361919
50
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
3 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
4 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
5 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
6 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
7 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
8 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
9 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
10 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
11 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
12 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
13 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
14 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
15 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
16 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
17 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
18 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
19 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
20 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
21 Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis Active, not recruiting NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
22 Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
23 Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
24 Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
25 Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis Unknown status NCT02033421
26 Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823 Not Applicable
27 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
28 Infective Endocarditis in the Elderly Unknown status NCT02910856
29 Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients Unknown status NCT00562653
30 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Unknown status NCT02887079
31 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
32 Inflammatory Mediator Profiles During Heart Valve Replacement Surgery Unknown status NCT02727413
33 PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
34 Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis Unknown status NCT01916005 Not Applicable
35 Q Fever and Auto-immunity Unknown status NCT02822807 Not Applicable
36 Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis Completed NCT02940340
37 18-FDG PET/CT Imaging and Clinical Decisions in Infective Endocarditis Completed NCT02287792 Not Applicable
38 Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism Completed NCT00947817 Not Applicable
39 Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008) Completed NCT03295045
40 Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective Endocaridtis Completed NCT02466139
41 Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis Completed NCT03612245
42 How to Improve Diagnosis in Infective Endocarditis Completed NCT00524212
43 Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis Completed NCT03048643 Not Applicable
44 Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438 Not Applicable
45 IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis Completed NCT00144885 Not Applicable
46 Outcomes Following Medical or Surgical Management of Endocarditis Completed NCT00166023
47 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
48 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273
49 15 Years Outcomes Following Bioprosthetic vs Mechanical Aortic Valve Replacement Between 50-65 Years Completed NCT03239509
50 PET/MR Imaging In Patients With Infective Endocarditis Recruiting NCT03626571

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

Anatomical Context for Infective Endocarditis

MalaCards organs/tissues related to Infective Endocarditis:

41
Heart, Brain, Endothelial, Liver, Kidney, Skin, Lung

Publications for Infective Endocarditis

Articles related to Infective Endocarditis:

(show top 50) (show all 1711)
# Title Authors Year
1
Pericardial effusion in infective endocarditis: The times they are a-changin'. ( 30301562 )
2019
2
Fasciitis in a Boy with Kingella Kingae Infective Endocarditis. ( 29870103 )
2018
3
Comparison of Dual I^-Lactam Therapy to Penicillin-Aminoglycoside Combination in Treatment of Enterococcus faecalis Infective Endocarditis. ( 29969596 )
2018
4
The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review. ( 29413230 )
2018
5
Case of infective endocarditis caused by implanted artificial hair pyoderma. ( 29923626 )
2018
6
Prognostic implications of a negative echocardiography in patients with infective endocarditis. ( 29409744 )
2018
7
Changes in the Association of Rising Infective Endocarditis With Mortality in People Who Inject Drugs. ( 29926083 )
2018
8
A broad-range PCR technique for the diagnosis of infective endocarditis. ( 29429763 )
2018
9
Acquired ventricular septal defect due to infective endocarditis. ( 29440841 )
2018
10
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
2018
11
Rare presentation of Candida albicans: infective endocarditis and a pulmonary coin lesion. ( 29513204 )
2018
12
Risk Stratification and Optimization of Cardiac Surgical Patients With Infective Endocarditis: Does It Matter? ( 29929896 )
2018
13
Bioprosthetic Versus Mechanical Valve Replacement for Infective Endocarditis: Focus on Recurrence Rates. ( 29452115 )
2018
14
Mitral valve repair versus replacement for infective endocarditis. What is better in the "real world"? ( 29958668 )
2018
15
Both-sided native valve infective endocarditis in a drug addict with incidental pneumoconiosis. ( 29704724 )
2018
16
Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature. ( 29390976 )
2018
17
Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report. ( 29973288 )
2018
18
Infective endocarditis in a patient with metastatic colorectal cancer. ( 29390605 )
2018
19
Infective endocarditis associated with <i>Bartonella henselae</i>: A case series. ( 29942769 )
2018
20
Infective Endocarditis Associated with Atrial Septal Defect in an Intravenous Drug Abuser: A Case Report. ( 29922523 )
2018
21
A pragmatic approach for mortality prediction after surgery in infective endocarditis: Optimizing and refining EuroSCORE. ( 29408350 )
2018
22
<i>Staphylococcus aureus</i> CC30 Lineage and Absence of <i>sed</i>,<i>j</i>,<i>r</i>-Harboring Plasmid Predict Embolism in Infective Endocarditis. ( 29938201 )
2018
23
Utility of cardiac computed tomography scanning in the diagnosis and pre-operative evaluation of patients with infective endocarditis. ( 29450741 )
2018
24
Marseille scoring system for empiric treatment of infective endocarditis. ( 29397446 )
2018
25
Gemella bergeri infective endocarditis: a case report and brief review of literature. ( 29444729 )
2018
26
Pulmonary artery intravascular abscess: A rare complication of incomplete infective endocarditis treatment in the setting of injection drug use. ( 29942758 )
2018
27
Outcome of Infective Endocarditis in the Current Era: Early Predictors of Poor Prognosis. ( 29382606 )
2018
28
External validation of the new predictive model for early mortality after surgical treatment of infective endocarditis: Analysis of the reliability of EndoSCORE. ( 29934231 )
2018
29
Corrigendum to &amp;quot;A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE&amp;quot;. [Int. J. Cardiol. Aug 15 2017;241:97-102.]. ( 29398138 )
2018
30
What are the main predictors of in-hospital mortality in patients with infective endocarditis: a review. ( 29382232 )
2018
31
Infective Endocarditis After Melody Valve Implantation in the Pulmonary Position: A Systematic Review. ( 29934419 )
2018
32
The Brief Case: An Unusual Cause of Infective Endocarditis after a Urological Procedure. ( 29941525 )
2018
33
Current knowledge among Japanese experienced general dentists regarding prevention of infective endocarditis. ( 29435864 )
2018
34
Echocardiography in Patients With Infective Endocarditis and the Impact of Diagnostic Delays on Clinical Outcomes. ( 29958712 )
2018
35
Viridans streptococcal infective endocarditis associated with fixed orthodontic appliance managed surgically by mitral valve plasty: A case report. ( 29979391 )
2018
36
Closing the Brief Case: An Unusual Cause of Infective Endocarditis after a Urological Procedure. ( 29941526 )
2018
37
A Review of Combination Antimicrobial Therapy for Enterococcus Faecalis Bloodstream Infections and Infective Endocarditis. ( 29390132 )
2018
38
The imaging features of cerebral septic infarction in two patients with infective endocarditis. ( 29948467 )
2018
39
Does antibiotic prophylaxis really prevent streptococci infective endocarditis? ( 29378813 )
2018
40
Guidelines in review: Comparison of ESC and AHA guidance for the diagnosis and management of infective endocarditis in adults. ( 29923105 )
2018
41
Dengue shock syndrome complicated with acute liver failure and kidney injury, infective endocarditis, and deep vein thrombosis: a case report. ( 30373645 )
2018
42
Antiphospholipid syndrome masquerading as a case of infective endocarditis. ( 29866682 )
2018
43
Complex regional pain syndrome type II arising from a gunshot wound (GSW) associated with infective endocarditis and aortic valve replacement. ( 30333197 )
2018
44
Duration and complications of diabetes mellitus and the associated risk of infective endocarditis. ( 30291010 )
2018
45
Acute Mitral Regurgitation of Unknown Etiology Associated with Disseminated Intravascular Coagulation Eventually Diagnosed as Enterococcus Faecalis Infective Endocarditis by Mitral Valve Surgery. ( 30531674 )
2018
46
Left-sided infective endocarditis caused by Streptococcus agalactiae: rare and serious. ( 30430377 )
2018
47
The Duke minor criterion "predisposing heart condition" in native valve infective endocarditis - a systematic review. ( 30440064 )
2018
48
Anti-Ace monoclonal antibody reduces Enterococcus faecalis aortic valve infection in a rat infective endocarditis model. ( 30445491 )
2018
49
Some invasive inpatient and outpatient procedures were linked to infective endocarditis. ( 30452565 )
2018
50
Right-sided infective endocarditis in patients with uncorrected ventricular septal defect and patent ductus arteriosus: Two case reports. ( 30455914 )
2018

Variations for Infective Endocarditis

Expression for Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for Infective Endocarditis

Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 IL6 LBP SERPINE1 TLR2 TNF
2
Show member pathways
12.47 ITGB3 LBP TLR2 TNF
3
Show member pathways
12.05 CRP F2 IL6 SERPINE1 TNF
4
Show member pathways
12.02 IL6 SERPINE1 TLR2 TNF
5 12 FCGR2A ITGB3 TLR2
6
Show member pathways
12 IL6 ITGB3 TNF TNNI3
7
Show member pathways
11.95 IL6 LBP TLR2 TNF
8 11.92 IL6 SERPINE1 TNF
9
Show member pathways
11.91 IL6 TLR2 TNF
10 11.9 FCGR2A ITGB3 TNF
11 11.88 FCGR2A GP1BA ITGB3
12 11.86 FCGR2A IL6 TNF
13 11.83 IL6 LBP TNF
14 11.81 FCGR2A IL6 LBP TLR2 TNF
15 11.76 IL6 SERPINE1 TNF
16
Show member pathways
11.74 F2 GP1BA ITGB3
17 11.73 IL6 TLR2 TNF
18 11.69 IL6 TLR2 TNF
19 11.69 GP1BA IL6 ITGB3 TNF
20
Show member pathways
11.66 CRP IL6 LBP
21 11.64 FCGR2A ITGB3 TLR2
22
Show member pathways
11.45 F2 FCGR2A IL6 TLR2 TNF
23 11.44 IL6 TLR2 TNF
24 11.41 FCGR2A IL6 ITGB3 TNF
25 11.38 IL6 TLR2 TNF
26 11.35 GP1BA IL6 TNF
27 11.09 FCGR2A GP1BA IL6 ITGB3 TNF
28 10.98 IL6 TNF
29 10.82 CRP IL6 TNF

GO Terms for Infective Endocarditis

Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 APOH CRP F2 GP1BA IL6 LBP
2 cell surface GO:0009986 9.1 APOH GP1BA ITGB3 LBP TLR2 TNF

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.94 CRP IL6 TLR2 TNF
2 inflammatory response GO:0006954 9.92 CRP IL6 TLR2 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.84 IL6 LBP SERPINE1 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL6 TLR2 TNF
5 platelet activation GO:0030168 9.81 F2 GP1BA IL6 ITGB3
6 platelet degranulation GO:0002576 9.79 APOH ITGB3 SERPINE1
7 defense response to Gram-negative bacterium GO:0050829 9.75 IL6 LBP SERPINE1
8 positive regulation of inflammatory response GO:0050729 9.73 SERPINE1 TLR2 TNF
9 positive regulation of interleukin-6 production GO:0032755 9.71 IL6 LBP TLR2 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 LBP TLR2 TNF
11 fibrinolysis GO:0042730 9.67 F2 GP1BA SERPINE1
12 blood coagulation, intrinsic pathway GO:0007597 9.65 APOH F2 GP1BA
13 defense response to Gram-positive bacterium GO:0050830 9.65 CRP IL6 LBP TLR2 TNF
14 microglial cell activation GO:0001774 9.63 TLR2 TNF
15 positive regulation of blood coagulation GO:0030194 9.63 APOH F2 SERPINE1
16 positive regulation of glial cell proliferation GO:0060252 9.62 IL6 TNF
17 acute-phase response GO:0006953 9.62 CRP F2 IL6 LBP
18 negative regulation of blood coagulation GO:0030195 9.61 APOH SERPINE1
19 regulation of blood coagulation GO:0030193 9.61 APOH F2 GP1BA
20 negative regulation of growth of symbiont in host GO:0044130 9.6 LBP TNF
21 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.59 CRP ITGB3
22 cellular response to lipoteichoic acid GO:0071223 9.58 LBP TLR2
23 opsonization GO:0008228 9.57 CRP LBP
24 positive regulation of neuroinflammatory response GO:0150078 9.55 IL6 TNF
25 negative regulation of fibrinolysis GO:0051918 9.54 APOH F2 SERPINE1
26 positive regulation of interleukin-8 production GO:0032757 9.46 LBP SERPINE1 TLR2 TNF
27 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
28 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 ITGB3 TNF

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 ITGB3 SERPINE1 TNF
2 lipopeptide binding GO:0071723 8.96 LBP TLR2
3 lipopolysaccharide binding GO:0001530 8.8 F2 LBP TLR2
4 protein binding GO:0005515 10.07 APOH CRP F2 FCGR2A GP1BA IL6

Sources for Infective Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....