Infective Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Infective Endocarditis

MalaCards integrated aliases for Infective Endocarditis:

Name: Infective Endocarditis 12 73 20 58 15 70
Bacterial Endocarditis 58 17 70
Endocarditis, Infective 73 20
Infectious Endocarditis 58
Endocarditis Infective 54


Orphanet: 58  
Rare infectious diseases

External Ids:

Disease Ontology 12 DOID:0060000
Orphanet 58 ORPHA570762
UMLS 70 C0014121 C1541923

Summaries for Infective Endocarditis

GARD : 20 Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. IE is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damage the heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.

MalaCards based summary : Infective Endocarditis, also known as bacterial endocarditis, is related to nonbacterial thrombotic endocarditis and mitral valve insufficiency, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Imipenem and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia : 73 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Infective Endocarditis

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1037)
# Related Disease Score Top Affiliating Genes
1 nonbacterial thrombotic endocarditis 32.1 PF4 IL6 F2 CRP APOH
2 mitral valve insufficiency 32.1 TNNI3 F2 CRP
3 aortic valve insufficiency 32.0 TNNI3 F2 CRP
4 congestive heart failure 31.8 TNNI3 TNF IL6 CRP
5 toxic shock syndrome 31.6 TNF TLR2 LBP IL6 CRP
6 tricuspid valve insufficiency 31.6 TNNI3 F2 CRP
7 cardiogenic shock 31.6 TNF IL6
8 hemopericardium 31.5 TNNI3 F2 CRP
9 rheumatic heart disease 31.5 TNF TLR2 IL6 CNMD
10 splenic infarction 31.4 F2 CRP APOH
11 splenic abscess 31.4 F2 CRP
12 cardiac tamponade 31.4 TNNI3 F2 CRP
13 osteomyelitis 31.3 TNF TLR2 IL6 CRP
14 pericardial effusion 31.3 TNNI3 IL6 F2 CRP
15 heart valve disease 31.3 TNNI3 F2 CRP CNMD APOH
16 septic arthritis 31.3 TNF TLR2 CRP
17 pericarditis 31.3 TNNI3 TNF IL6 CRP
18 rheumatic fever 31.2 TNF TLR2 IL6 FCGR2A
19 pulmonary edema 31.2 TNNI3 TNF F2 CRP
20 pulmonary embolism 31.2 TNNI3 SERPINE1 GP1BA F2 CRP APOH
21 mitral valve disease 31.1 TNNI3 F2 CRP
22 q fever 31.1 TNF TLR2 IL6
23 exanthem 31.1 TNF IL6 F2 CRP
24 mitral valve stenosis 31.1 PPBP PF4 F2 CRP
25 endophthalmitis 31.1 TNF TLR2 IL6 CRP
26 vasculitis 31.1 TNF IL6 IL17A CRP APOH
27 pleural empyema 31.0 IL6 F2 CRP
28 endocarditis 31.0 TNNI3 TNF TLR6 TLR2 SERPINE1 PPBP
29 epidural abscess 30.9 F2 CRP
30 disease by infectious agent 30.9 TNF TLR2 LBP IL6 IL17A FCGR2A
31 disseminated intravascular coagulation 30.9 TNF SERPINE1 IL6 F2 CRP
32 cellulitis 30.9 TNF IL6 F2 CRP
33 acute myocardial infarction 30.9 TNNI3 SERPINE1 PF4 IL6 CRP
34 pulmonary hypertension 30.9 TNF SERPINE1 IL6 F2 CRP
35 pyelonephritis 30.8 TNF IL6 CRP
36 haemophilus influenzae 30.8 TNF TLR2
37 dermatitis 30.8 TNF TLR2 IL6 IL17A
38 bacteriuria 30.8 TLR2 IL6 CRP
39 spondylitis 30.8 TNF IL6 IL17A CRP
40 meningoencephalitis 30.8 TNF IL6 CRP
41 aortitis 30.8 TNF IL6 IL17A CRP
42 acute cystitis 30.8 TNF IL6 F2 CRP
43 patent foramen ovale 30.8 TNNI3 SERPINE1 F2 CRP APOH
44 acalculous cholecystitis 30.7 F2 CRP
45 myocarditis 30.7 TNNI3 TNF IL6 IL17A
46 branch retinal artery occlusion 30.7 F2 CRP APOH
47 chlamydia 30.7 TNF TLR2 IL6 IL17A CRP
48 mediastinitis 30.7 F2 CRP
49 cerebritis 30.7 TNF CRP APOH
50 cryoglobulinemia 30.6 TNF IL6 APOH

Graphical network of the top 20 diseases related to Infective Endocarditis:

Diseases related to Infective Endocarditis

Symptoms & Phenotypes for Infective Endocarditis

UMLS symptoms related to Infective Endocarditis:

osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 AQP9 CNMD FCGR2A GP1BA IBSP IL17A
2 homeostasis/metabolism MP:0005376 10.13 APOH AQP9 CNMD CRP F2 FCGR2A
3 immune system MP:0005387 10 AQP9 CNMD CRP F2 FCGR2A IBSP
4 respiratory system MP:0005388 9.56 F2 IL17A IL6 ITGB3 SERPINE1 TLR2
5 skeleton MP:0005390 9.4 AQP9 CNMD F2 FCGR2A IBSP IL17A

Drugs & Therapeutics for Infective Endocarditis

Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
Fosfomycin Approved Phase 4 23155-02-4 446987
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
6 Anesthetics Phase 4
7 Antitubercular Agents Phase 4
8 Anti-Bacterial Agents Phase 4
9 Anti-Infective Agents Phase 4
10 methicillin Phase 4
11 Gentamicins Phase 4
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
Netilmicin Approved, Investigational Phase 3 56391-56-1 6857423 441306
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
Ofloxacin Approved Phase 3 82419-36-1 4583
Rifampicin Approved Phase 3 13292-46-1 5381226 5458213
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
Ceftobiprole Approved, Investigational Phase 3 209467-52-7 6918430
Aztreonam Approved Phase 3 78110-38-0 5362041 5742832
Vancomycin Approved Phase 3 1404-90-6 14969 441141
Cloxacillin Approved, Investigational, Vet_approved Phase 3 61-72-3 6098
Oxacillin Approved, Investigational Phase 3 66-79-5 6196
Cefazolin Approved Phase 3 25953-19-9 33255 656510
Telavancin Approved Phase 3 372151-71-8
Nafcillin Approved, Investigational Phase 3 147-52-4, 985-16-0 8982
Ceftobiprole medocaril Experimental, Investigational Phase 3 376653-43-9
29 Penicillin G Procaine Phase 3
30 Penicillin G Benzathine Phase 3
31 Fluoroquinolones Phase 3
32 Cytochrome P-450 Enzyme Inhibitors Phase 3
33 penicillins Phase 3
Naloxone Approved, Vet_approved Phase 2 465-65-6 5284596
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 2 52485-79-7 644073 40400
Dalbavancin Approved, Investigational Phase 2 171500-79-1, 91097-81-3 122186
37 Narcotics Phase 2
38 Analgesics Phase 2
39 Analgesics, Opioid Phase 2
40 Buprenorphine, Naloxone Drug Combination Phase 2
41 Narcotic Antagonists Phase 2
42 Antibiotics, Antitubercular Phase 2
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
45 Autoantibodies
46 Lactams
47 Adrenergic alpha-Agonists
48 Analgesics, Non-Narcotic
49 Hypnotics and Sedatives
50 Adrenergic Agents

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
4 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
5 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
6 Short-course Antibiotic Regimen Compared to Conventional Antibiotic Treatment for Gram-positive Cocci Infective Endocarditis: Randomized Clinical Trial Recruiting NCT04222257 Phase 4 Antibiotics;Antibiotics
7 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
8 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
9 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
10 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
11 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
12 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
13 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Recruiting NCT04160468 Phase 3 Exebacase;Placebo
14 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
15 Phase II Clinical Trial to Evaluate an Antibiotic Regimen Pharmacokinetic Applicable to Outpatient Parenteral Antimicrobial Therapy in Enterococcus Faecalis Infective Endocarditis Unknown status NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
16 Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections Recruiting NCT04677114 Phase 2 Buprenorphine and Outpatient Parenteral Antibiotic Therapy;Buprenorphine and standard of care antibiotic treatment
17 Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis" Recruiting NCT04691440 Phase 2 Hyperbaric oxygen
18 A Multi-centre Open Label Randomized Controlled Phase IIB Trial Comparing Vancomycin Versus Daptomycin for the Treatment of MRSA Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
19 Phase 2, Open-Label, Randomized, Multicenter Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Documented Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
20 Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms Terminated NCT02790996 Phase 2 Vancomycin
21 Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis Unknown status NCT02252900
22 Etiology of Endocarditis in Negative Blood Cultures Unknown status NCT02816307
23 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
24 Molecular Imaging in Infective Endocarditis Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR) and Computed Tomography (PET/CT) Unknown status NCT03626571
25 The Use of Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
26 Treatment of Infective Endocarditis by Vancomycin and Gentamycin in Assiut University Children Hospital Unknown status NCT03688659 Vancomycin and gentamycin
27 Study of Autoantibodies in Infective Endocarditis Unknown status NCT00562653
28 Detection of the Most Common Micro Organism of Infective Endocarditis in Assiut University Hospital Unknown status NCT03487653
29 Beta-lactam Pharmacokinetic Profiles in Patients With Infective Endocarditis Unknown status NCT02033421
30 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
31 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Unknown status NCT02887079
32 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Unknown status NCT02698930 dexmedetomidine;Normal saline
33 Clinical Metagenomics of Infective Endocarditis Unknown status NCT03199287
34 Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis - A Multicenter Partially Randomized Preference Trial (EARLY Study) Unknown status NCT03411499
35 Impact of Setting up a Multidisciplinary Consensus Meeting in the Prognosis and Management of Infectious Endocarditis at Strasbourg University Hospital. Unknown status NCT03429153
36 Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis Using the Imaging Method of Cutaneous Laser Speckle Flowmetry Completed NCT02940340
37 CATS-CARE: Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis Completed NCT03048643
38 Evolution of the Profile of Infectious Endocarditis in France in 2008 Completed NCT03295045
39 Effect of 18-FDG PET/CT Imaging on Clinical Decision Making During the Acute Phase of Infective Endocarditis: a Multicenter Prospective Impact Study Completed NCT02287792
40 Evaluation of an Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438
41 Inflammatory and Vasoactive Mediator Profiles and Pathogen Characterization During Heart Valve Replacement Surgery Completed NCT02727413
42 INfecTive ENdocarditis After Transcatheter Aortic Valve Replacement (TAVR) a National SwEdish Study (INTENSE) Completed NCT03768180
43 Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis Completed NCT03612245
44 Acute Kidney Injury During Daptomycin Versus Vancomycin Treatment in Cardiovascular Critically Ill Patients: a Propensity Score Matched Analysis Completed NCT03961503 Daptomycin (DAP) treatment;Vancomycin (VAN) treatment
45 Revealing Mechanisms and Investigating Efficacy of Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis - a Multicentric Randomized Controlled Group Sequential Trial Completed NCT03266302
46 Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes Among Infective Endocaridtis Patients in a Tertiary-care Centre in Kerala Completed NCT02466139
47 Infective Endocarditis in the Elderly: Description of the Geriatric Characteristics and Their Influence on Therapeutic Care and the Morbidity and Mortality at 3 Months (ELDERL-IE) Completed NCT02910856
48 CopenHeart IE - A Randomized Clinical Trial Investigating the Effect and Meaning of Integrated Rehabilitation Versus Usual Follow-up of Patients Treated for Infective Endocarditis Completed NCT01512615
49 Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism. Completed NCT00947817
50 Contribution of 18F-FDG PET-CT in the Diagnosis and the Detection of Peripheral Emboli of Infectious Endocarditis on Native Valves Completed NCT03695861

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

Anatomical Context for Infective Endocarditis

MalaCards organs/tissues related to Infective Endocarditis:

Heart, Brain, Kidney, Endothelial, Skin, Spleen, Colon

Publications for Infective Endocarditis

Articles related to Infective Endocarditis:

(show top 50) (show all 16162)
# Title Authors PMID Year
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]. 54 61
17339740 2007
Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. 61 54
16980969 2006
Metabolism of glycoprotein-derived sialic acid and N-acetylglucosamine by Streptococcus oralis. 54 61
8704962 1996
Sterile subconjunctival abscess in an HLA-B51-positive patient with ulcerative colitis. 61
33659764 2021
Simultaneous bilateral choroidal neovascularization associated with Staphylococcus aureus infective endocarditis: A case report. 61
33681530 2021
Clinical characteristics and outcomes in patients with echocardiographic left ventricular spontaneous echo contrast. 61
33577908 2021
Infective endocarditis in patients with aortic grafts. 61
33592240 2021
Long-term follow-up of patients with infective endocarditis in a tertiary referral center. 61
33545260 2021
Klebsiella oxytoca and Emerging Nosocomial Infections. 61
33656584 2021
Endocarditis due to Trichosporon beigelii 11 years after mitral valve replacement. 61
33752978 2021
A prospective comparison of four methods for preventing pacemaker pocket infections. 61
33001439 2021
[Evolution of antimicrobial resistance and mortality in Staphylococcus aureus endocarditis during 15 years in a university hospital]. 61
33491408 2021
Opioid abuse surveillance in patients with endocarditis. 61
32814665 2021
Endocarditis at a large community hospital with on-site cardiac surgery. 61
33665354 2021
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the infection of heart. 61
33053614 2021
Late Surgical Treatment for Transcatheter Aortic Valve Prosthesis Dysfunction. 61
32979373 2021
Is 67gallium dead? A retrospective review of 67gallium imaging in a single tertiary referral centre. 61
33323867 2021
Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Infective Endocarditis in Patients With Adult Congenital Heart Disease. 61
33790144 2021
Infective endocarditis in patients with heart transplantation. 61
33309761 2021
Optimum surgical treatment for tricuspid valve infective endocarditis: An analysis of the Society of Thoracic Surgeons national database. 61
31864695 2021
Huge Mycotic Aneurysm at the Celiac Trunk in a Patient With Severe Aortic Regurgitation Due to Infective Endocarditis. 61
33790145 2021
Serratia Marcescens Infective Endocarditis Complicated by Aortic Root Abscess and Aorta to Right Atrial Fistula. 61
33262023 2021
Analysis of the frequency of bacteraemia of dental origin implicated in infective endocarditis in patients requiring valve surgery. 61
33293181 2021
Infective Endocarditis in Patients on Chronic Hemodialysis. 61
33795037 2021
Exploring the socioeconomic consequences of infective endocarditis. 61
32331699 2021
Septal and posterior sliding plasty in tricuspid valve endocarditis. 61
33124062 2021
Long-term outcomes of aortic root replacement for endocarditis. 61
33651483 2021
The role of dalbavancin for Gram positive infections in the COVID-19 era: state of the art and future perspectives. 61
33682593 2021
Trends and Predictors of Transcatheter Aortic Valve Implantation Related In-Hospital Mortality (From the National Inpatient Sample Database). 61
33359229 2021
Aortic homograft implantation after Ozaki procedure: Case report. 61
33752029 2021
Cutaneous Vasculitis and Generalized Lymphadenopathy Associated with Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Endocarditis: A Rare Case Report. 61
33284398 2021
Central nervous system candidiasis beyond neonates: Lessons from a nationwide study. 61
32577733 2021
Incidence, Cause, and Outcome of Reinterventions after Aortic Root Replacement. 61
33705779 2021
Mycotic iliac artery aneurysm with appendicitis in a pediatric patient. 61
33742645 2021
An In Vitro Model to Study Endothelialization of Cardiac Graft Tissues Under Flow. 61
33544046 2021
Midterm results of homografts in pulmonary position: a retrospective single-center study. 61
33642710 2021
Optimizing cardiovascular imaging in Staphylococcus aureus endocarditis. 61
33704836 2021
Vancomycin-induced thrombocytopenia in endocarditis: A case report and review of literature. 61
33728314 2021
In silico prediction, molecular docking and binding studies of acetaminophen and dexamethasone to Enterococcus faecalis diaminopimelate epimerase. 61
33719110 2021
Early and Two-year Outcomes after Sutureless and Conventional Aortic Valve Replacement: a Nationwide Population-based Study. 61
33686809 2021
Forgoing transesophageal echocardiogram in selected patients with complicated Staphylococcus aureus bacteremia. 61
33392784 2021
A qualitative assessment of discharge against medical advice among patients hospitalized for injection-related bacterial infections in West Virginia. 61
33765516 2021
PET/CT with 18F-FDG in suspected intracardiac device-related infections: analysis of performance and diagnostic usefulness. 61
32471719 2021
Fusobacterium necrophorum Endocarditis with Liver Abscesses: A Case Report and Review of the Literature. 61
33642481 2021
The role of cardiac computed tomography in the diagnosis of prosthetic valve endocarditis - A comparison with transthoracic and transesophageal echocardiography and intra-operative findings. 61
33740628 2021
Deranged Coagulation Profile Secondary to Cefazolin Use: Case Report. 61
33804372 2021
Transvenous Lead Extraction in Patients with Persistent Left Superior Vena Cava. 61
33783892 2021
Utility of Susceptibility-Weighted Angiography Sequence in the Diagnosis of Ruptured Infectious Aneurysms. 61
33662605 2021
Clinical Outcomes of Adults With Bicuspid Aortic Valve: A European Perspective. 61
33673916 2021
Erysipelothrix rhusiopathiae Endocarditis in a Patient With Severe Unicuspid Aortic Valve Damage Complicated With Acquired Ventricular Septal Defect. 61
32920167 2021

Variations for Infective Endocarditis

Expression for Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for Infective Endocarditis

Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.29 TNF TLR2 IL6 IL17A
Show member pathways
12.29 TNF PPBP PF4 IL6
Show member pathways
12.22 TNF TLR6 TLR2 IL6
Show member pathways
Show member pathways
12.17 PF4 ITGB3 F2 CEACAM8
Show member pathways
13 12.12 TNF TLR6 TLR2 IL6
Show member pathways
15 12.07 TLR6 TLR2 ITGB3 FCGR2A
16 11.95 ITGB3 GP1BA FCGR2A F2
17 11.89 TNF LBP IL6 IL17A
Show member pathways
20 11.81 TNF ITGB3 IL6 GP1BA
Show member pathways
11.77 LBP IL6 CRP
22 11.75 TNF TLR2 IL6 IL17A
Show member pathways
11.72 TLR6 TLR2 IL6 IL17A
24 11.66 TLR6 TLR2 ITGB3 FCGR2A
25 11.56 TNF TLR2 IL6
27 11.49 TNF TLR2 IL6
28 11.46 TNF IL6 GP1BA
29 11.44 TNF TLR2 IL6 FCGR2A
30 11.23 TNF IL6 IL17A
Show member pathways
11.23 TNF TLR6 TLR2 IL6 IL17A
33 10.95 TNF PPBP PF4 ITGB3 IL6 IL17A
34 10.82 TNF IL6 CRP

GO Terms for Infective Endocarditis

Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF SERPINE1 PPBP PF4 LBP IL6
2 cell surface GO:0009986 9.7 TNF TLR2 LBP ITGB3 GP1BA CEACAM8
3 extracellular space GO:0005615 9.44 TNF SERPINE1 PPBP PF4 LBP IL6
4 platelet alpha granule lumen GO:0031093 9.43 SERPINE1 PPBP PF4

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TNF TLR6 TLR2 PF4 IL6 CRP
2 cytokine-mediated signaling pathway GO:0019221 10.03 TNF PF4 LBP IL6 IL17A
3 extracellular matrix organization GO:0030198 9.99 TNF SERPINE1 ITGB3 IBSP
4 leukocyte migration GO:0050900 9.97 TNF ITGB3 F2 CEACAM8
5 immune response GO:0006955 9.97 TNF TLR6 TLR2 PPBP PF4 IL6
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR6 TLR2 IL6
7 platelet degranulation GO:0002576 9.92 SERPINE1 PPBP PF4 ITGB3 APOH
8 defense response to Gram-negative bacterium GO:0050829 9.88 SERPINE1 LBP IL6 IL17A
9 platelet activation GO:0030168 9.88 PF4 ITGB3 IL6 GP1BA F2
10 cellular response to lipopolysaccharide GO:0071222 9.88 TNF SERPINE1 PPBP PF4 LBP IL6
11 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.86 PPBP PF4 F2
12 inflammatory response GO:0006954 9.86 TNF TLR6 TLR2 PPBP PF4 IL6
13 positive regulation of tumor necrosis factor production GO:0032760 9.85 TLR2 PF4 LBP IL6 IL17A
14 positive regulation of interleukin-1 beta production GO:0032731 9.83 TNF IL6 IL17A
15 toll-like receptor signaling pathway GO:0002224 9.82 TLR6 TLR2 LBP
16 negative regulation of endothelial cell proliferation GO:0001937 9.81 TNF CNMD APOH
17 positive regulation of chemokine production GO:0032722 9.81 TNF TLR2 LBP IL6
18 acute-phase response GO:0006953 9.8 LBP IL6 F2 CRP
19 positive regulation of JAK-STAT cascade GO:0046427 9.79 TNF IL6 F2
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 TNF TLR2 LBP
21 microglial cell activation GO:0001774 9.78 TNF TLR6 TLR2
22 fibrinolysis GO:0042730 9.75 SERPINE1 GP1BA F2
23 blood coagulation, intrinsic pathway GO:0007597 9.74 GP1BA F2 APOH
24 positive regulation of blood coagulation GO:0030194 9.73 SERPINE1 F2 APOH
25 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.73 TNF TLR6 IL6 IL17A
26 regulation of blood coagulation GO:0030193 9.72 GP1BA F2 APOH
27 positive regulation of interleukin-8 production GO:0032757 9.72 TNF TLR2 SERPINE1 LBP IL6
28 negative regulation of fibrinolysis GO:0051918 9.71 SERPINE1 F2 APOH
29 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL6
30 cell activation GO:0001775 9.69 TLR6 TLR2
31 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 LBP
32 negative regulation of vascular wound healing GO:0061044 9.68 TNF SERPINE1
33 cellular response to bacterial lipopeptide GO:0071221 9.68 TLR6 TLR2
34 regulation of cytokine secretion GO:0050707 9.67 TLR6 TLR2
35 vascular endothelial growth factor production GO:0010573 9.67 TNF IL6
36 opsonization GO:0008228 9.66 LBP CRP
37 cellular response to diacyl bacterial lipopeptide GO:0071726 9.65 TLR6 TLR2
38 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.64 TLR6 TLR2
39 nitric oxide metabolic process GO:0046209 9.63 TLR6 TLR2
40 defense response to Gram-positive bacterium GO:0050830 9.63 TNF TLR2 LBP IL6 IL17A CRP
41 response to bacterial lipoprotein GO:0032493 9.62 TLR6 TLR2
42 detection of diacyl bacterial lipopeptide GO:0042496 9.59 TLR6 TLR2
43 negative regulation of lipid storage GO:0010888 9.26 TNF ITGB3 IL6 CRP
44 positive regulation of interleukin-6 production GO:0032755 9.1 TNF TLR6 TLR2 LBP IL6 IL17A

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 TNNI3 TNF TLR6 TLR2 SERPINE1 PPBP
2 lipopolysaccharide binding GO:0001530 9.43 TLR2 LBP F2
3 cytokine activity GO:0005125 9.35 TNF PPBP PF4 IL6 IL17A
4 lipopeptide binding GO:0071723 8.8 TLR6 TLR2 LBP

Sources for Infective Endocarditis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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