MCID: INF034
MIFTS: 54

Infective Endocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Infective Endocarditis

MalaCards integrated aliases for Infective Endocarditis:

Name: Infective Endocarditis 12 76 53 15 73
Endocarditis, Infective 76 53
Endocarditis Infective 55
Bacterial Endocarditis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060000

Summaries for Infective Endocarditis

NIH Rare Diseases : 53 Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. IE is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damage the heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.

MalaCards based summary : Infective Endocarditis, also known as endocarditis, infective, is related to cardiogenic shock and splenic infarction, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and IL-1 Family Signaling Pathways. The drugs Lidocaine and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia : 76 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Infective Endocarditis

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 30.4 CRP IL6
2 splenic infarction 30.1 APOH F2
3 pericarditis 30.0 CRP IL6 TNF
4 acute myocardial infarction 30.0 CRP SERPINE1 TNNI3
5 streptococcal toxic-shock syndrome 29.9 IL6 TNF
6 bursitis 29.9 CRP SH3BP5
7 myocarditis 29.7 IL6 TNF TNNI3
8 brucellosis 29.7 CRP IL6 TNF
9 pyelonephritis 29.6 CRP IL6 TNF
10 end stage renal failure 29.6 CRP IL6 TNF
11 limb ischemia 29.6 IL6 TNF TNNI3
12 kawasaki disease 29.5 CRP FCGR2A IL6 TNF
13 haemophilus influenzae 29.5 TLR2 TNF
14 heart disease 29.5 CRP F2 IL6 TNF TNNI3
15 retinal artery occlusion 29.5 APOH F2 SERPINE1
16 psoriatic arthritis 29.4 CRP IL6 TNF
17 arteriovenous fistula 29.3 APOH IL6
18 pneumonia 29.2 CRP IL6 TLR2 TNF
19 toxic shock syndrome 29.2 IL6 TLR2 TNF
20 temporal arteritis 29.1 APOH CRP IL6
21 takayasu arteritis 29.1 CRP FCGR2A IL6 TNF
22 stroke, ischemic 29.0 APOH CRP F2 SERPINE1
23 vasculitis 29.0 APOH CRP TNF
24 meningitis 28.8 CRP FCGR2A IL6 TLR2 TNF
25 thrombophilia 28.7 APOH F2 SERPINE1
26 pulmonary embolism 28.6 APOH CRP F2 SERPINE1 TNNI3
27 thrombosis 28.6 APOH F2 GP1BA SERPINE1
28 peritonitis 28.2 CRP F2 IL6 LBP TLR2 TNF
29 endocarditis 28.1 APOH AQP9 CRP F2 FCGR2A IL6
30 systemic lupus erythematosus 27.5 APOH CRP FCGR2A IL6 TNF
31 purpura 26.9 APOH CRP F2 GP1BA ITGB3 TNF
32 myocardial infarction 26.8 CRP F2 GP1BA IL6 ITGB3 SERPINE1
33 orthostatic intolerance 11.4
34 marantic endocarditis 11.4
35 malignant otitis externa 11.0 CRP F2
36 subacute bacterial endocarditis 10.9
37 chronic thromboembolic pulmonary hypertension 10.9 CRP F2
38 abdominal tuberculosis 10.9 CRP F2
39 ischemic neuropathy 10.8 CRP F2
40 cold agglutinin disease 10.8 CRP IL6
41 cryopyrin-associated periodic syndrome 10.7 CRP IL6
42 acute cholangitis 10.7 CRP IL6
43 neutrophilia, hereditary 10.7 CRP IL6
44 blue toe syndrome 10.7 CRP F2 SERPINE1
45 uremic pruritus 10.6 CRP IL6
46 venous insufficiency 10.6 CRP F2 SERPINE1
47 spinal disease 10.6 CRP IL6
48 castleman disease 10.6 CRP IL6
49 marburg hemorrhagic fever 10.6 F2 TNF
50 rheumatic myocarditis 10.5 CRP TNNI3

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to Infective Endocarditis

Symptoms & Phenotypes for Infective Endocarditis

UMLS symptoms related to Infective Endocarditis:


osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 TLR2 FCGR2A GP1BA TNF IL6 ITGB3
2 homeostasis/metabolism MP:0005376 10 TLR2 GP1BA TNF IL6 ITGB3 APOH
3 cardiovascular system MP:0005385 9.97 F2 TLR2 TNF IL6 TNNI3 ITGB3
4 immune system MP:0005387 9.85 TLR2 FCGR2A TNF IL6 ITGB3 LBP
5 liver/biliary system MP:0005370 9.43 TLR2 TNF IL6 ITGB3 LBP SERPINE1
6 respiratory system MP:0005388 9.17 F2 TLR2 TNF IL6 TNNI3 ITGB3

Drugs & Therapeutics for Infective Endocarditis

Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
2
Fosfomycin Approved Phase 4 23155-02-4 446987
3
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
4
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 441141 14969
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Hexetidine Approved, Investigational Phase 4 141-94-6
8
Racepinephrine Approved Phase 4 329-65-7 838
9
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
10
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
11
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
14 Anesthetics Phase 4,Phase 2,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Anesthetics, Local Phase 4,Phase 2
17 Anti-Arrhythmia Agents Phase 4,Phase 2
18 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
19 Diuretics, Potassium Sparing Phase 4,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Sodium Channel Blockers Phase 4,Phase 2
22 beta-Lactams Phase 4
23 Lactams Phase 4
24 methicillin Phase 4,Phase 3,Phase 2
25 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Adrenergic Agents Phase 4,Not Applicable
27 Adrenergic Agonists Phase 4,Not Applicable
28 Adrenergic alpha-Agonists Phase 4,Not Applicable
29 Adrenergic beta-Agonists Phase 4
30 Anti-Asthmatic Agents Phase 4
31 Anti-Infective Agents, Local Phase 4
32 Autonomic Agents Phase 4,Phase 3
33 Bronchodilator Agents Phase 4
34 Chlorhexidine gluconate Phase 4
35 Dermatologic Agents Phase 4
36 Disinfectants Phase 4
37 Epinephryl borate Phase 4
38 Mydriatics Phase 4
39 Neurotransmitter Agents Phase 4,Not Applicable
40 Pharmaceutical Solutions Phase 4
41 Respiratory System Agents Phase 4
42 Vasoconstrictor Agents Phase 4
43 Amoxicillin-Potassium Clavulanate Combination Phase 4
44 beta-Lactamase Inhibitors Phase 4
45 Clavulanic Acid Phase 4
46 Gentamicins Phase 4,Phase 3
47
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
48
Netilmicin Approved, Investigational Phase 3 56391-56-1 441306 6857423
49
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
50
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Unknown status NCT01920126 Phase 4 sodium bicarbonate;Saline
3 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
4 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
5 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
6 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
7 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
8 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
9 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
10 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
11 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
12 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
13 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
14 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
15 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
16 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Active, not recruiting NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
17 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Not yet recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
18 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
19 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
20 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
21 Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
22 Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
23 Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
24 Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis Unknown status NCT02033421
25 Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823 Not Applicable
26 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
27 Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients Unknown status NCT00562653
28 PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
29 Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis Unknown status NCT01916005 Not Applicable
30 Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis Completed NCT02940340
31 18-FDG PET/CT Imaging and Clinical Decisions in Infective Endocarditis Completed NCT02287792 Not Applicable
32 Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism Completed NCT00947817 Not Applicable
33 Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008) Completed NCT03295045
34 Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective Endocaridtis Completed NCT02466139
35 How to Improve Diagnosis in Infective Endocarditis Completed NCT00524212
36 Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438 Not Applicable
37 IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis Completed NCT00144885 Not Applicable
38 Outcomes Following Medical or Surgical Management of Endocarditis Completed NCT00166023
39 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
40 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273
41 Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis Recruiting NCT03266302 Not Applicable
42 French National Observatory on Infective Endocarditis Recruiting NCT03272724
43 Clinical Metagenomics of Infective Endocarditis Recruiting NCT03199287
44 Infective Endocarditis in the Elderly Recruiting NCT02910856
45 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Recruiting NCT02887079
46 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Recruiting NCT02856607
47 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Recruiting NCT02698930 Not Applicable dexmedetomidine;Normal saline
48 Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis Recruiting NCT03411499 Not Applicable
49 PRetest prObability of Infectious ENDOCARDITIS for Appropriate Criteria Regarding Transesophageal ECHOcardiography in Tertiary Care Facilities (PRO ENDOCARDITIS ECHO-Study) Recruiting NCT03365193
50 Etiology of Endocarditis in Negative Blood Cultures Recruiting NCT02816307 Not Applicable

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

Anatomical Context for Infective Endocarditis

MalaCards organs/tissues related to Infective Endocarditis:

41
Heart, Endothelial, Skin, Liver, Brain, Kidney, Colon

Publications for Infective Endocarditis

Articles related to Infective Endocarditis:

(show top 50) (show all 837)
# Title Authors Year
1
Fasciitis in a Boy with Kingella Kingae Infective Endocarditis. ( 29870103 )
2018
2
Comparison of Dual I^-Lactam Therapy to Penicillin-Aminoglycoside Combination in Treatment of Enterococcus faecalis Infective Endocarditis. ( 29969596 )
2018
3
The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review. ( 29413230 )
2018
4
Case of infective endocarditis caused by implanted artificial hair pyoderma. ( 29923626 )
2018
5
Prognostic implications of a negative echocardiography in patients with infective endocarditis. ( 29409744 )
2018
6
Changes in the Association of Rising Infective Endocarditis With Mortality in People Who Inject Drugs. ( 29926083 )
2018
7
A broad-range PCR technique for the diagnosis of infective endocarditis. ( 29429763 )
2018
8
Acquired ventricular septal defect due to infective endocarditis. ( 29440841 )
2018
9
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
2018
10
Rare presentation of Candida albicans: infective endocarditis and a pulmonary coin lesion. ( 29513204 )
2018
11
Risk Stratification and Optimization of Cardiac Surgical Patients With Infective Endocarditis: Does It Matter? ( 29929896 )
2018
12
Bioprosthetic Versus Mechanical Valve Replacement for Infective Endocarditis: Focus on Recurrence Rates. ( 29452115 )
2018
13
Mitral valve repair versus replacement for infective endocarditis. What is better in the "real world"? ( 29958668 )
2018
14
Both-sided native valve infective endocarditis in a drug addict with incidental pneumoconiosis. ( 29704724 )
2018
15
Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature. ( 29390976 )
2018
16
Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report. ( 29973288 )
2018
17
Infective endocarditis in a patient with metastatic colorectal cancer. ( 29390605 )
2018
18
Infective endocarditis associated with <i>Bartonella henselae</i>: A case series. ( 29942769 )
2018
19
Infective Endocarditis Associated with Atrial Septal Defect in an Intravenous Drug Abuser: A Case Report. ( 29922523 )
2018
20
A pragmatic approach for mortality prediction after surgery in infective endocarditis: Optimizing and refining EuroSCORE. ( 29408350 )
2018
21
<i>Staphylococcus aureus</i> CC30 Lineage and Absence of <i>sed</i>,<i>j</i>,<i>r</i>-Harboring Plasmid Predict Embolism in Infective Endocarditis. ( 29938201 )
2018
22
Utility of cardiac computed tomography scanning in the diagnosis and pre-operative evaluation of patients with infective endocarditis. ( 29450741 )
2018
23
Marseille scoring system for empiric treatment of infective endocarditis. ( 29397446 )
2018
24
Gemella bergeri infective endocarditis: a case report and brief review of literature. ( 29444729 )
2018
25
Pulmonary artery intravascular abscess: A rare complication of incomplete infective endocarditis treatment in the setting of injection drug use. ( 29942758 )
2018
26
Outcome of Infective Endocarditis in the Current Era: Early Predictors of Poor Prognosis. ( 29382606 )
2018
27
External validation of the new predictive model for early mortality after surgical treatment of infective endocarditis: Analysis of the reliability of EndoSCORE. ( 29934231 )
2018
28
Corrigendum to &amp;quot;A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE&amp;quot;. [Int. J. Cardiol. Aug 15 2017;241:97-102.]. ( 29398138 )
2018
29
What are the main predictors of in-hospital mortality in patients with infective endocarditis: a review. ( 29382232 )
2018
30
Infective Endocarditis After Melody Valve Implantation in the Pulmonary Position: A Systematic Review. ( 29934419 )
2018
31
The Brief Case: An Unusual Cause of Infective Endocarditis after a Urological Procedure. ( 29941525 )
2018
32
Current knowledge among Japanese experienced general dentists regarding prevention of infective endocarditis. ( 29435864 )
2018
33
Echocardiography in Patients With Infective Endocarditis and the Impact of Diagnostic Delays on Clinical Outcomes. ( 29958712 )
2018
34
Viridans streptococcal infective endocarditis associated with fixed orthodontic appliance managed surgically by mitral valve plasty: A case report. ( 29979391 )
2018
35
Closing the Brief Case: An Unusual Cause of Infective Endocarditis after a Urological Procedure. ( 29941526 )
2018
36
A Review of Combination Antimicrobial Therapy for Enterococcus Faecalis Bloodstream Infections and Infective Endocarditis. ( 29390132 )
2018
37
The imaging features of cerebral septic infarction in two patients with infective endocarditis. ( 29948467 )
2018
38
Does antibiotic prophylaxis really prevent streptococci infective endocarditis? ( 29378813 )
2018
39
Guidelines in review: Comparison of ESC and AHA guidance for the diagnosis and management of infective endocarditis in adults. ( 29923105 )
2018
40
Long-term risk of hemorrhagic stroke in patients with infective endocarditis: a Danish nationwide cohort study. ( 29920590 )
2018
41
Management Considerations in Infective Endocarditis: A Review. ( 29971402 )
2018
42
'A pragmatic approach for mortality prediction after surgery in infective endocarditis' by Ferreira-GonzA!lez, et al. ( 29981469 )
2018
43
Septic Shock, Meningoencephalitis and Multiple Pulmonary Emboli: Case Report of an Uncommon Clinical Presentation of Ventricular Septal Defect Acute Infective Endocarditis. ( 29762935 )
2017
44
Invasiveness of left- and right-sided infective endocarditis: Does pressure explain pathology? ( 28939112 )
2017
45
Early Diagnosis of Infective Endocarditis by Brain T2*-Weighted Magnetic Resonance Imaging. ( 28943531 )
2017
46
Rarity of invasiveness in right-sided infective endocarditis. ( 28951083 )
2017
47
A risk factor analysis for in-hospital mortality after surgery for infective endocarditis and a proposal of a new predictive scoring system. ( 28054252 )
2017
48
An Ineffective Differential Diagnosis of Infective Endocarditis and Rheumatic Heart Disease after Streptococcal Skin and Soft Tissue Infection. ( 28794364 )
2017
49
A Curious Case of Blood-Culture-Negative Infective Endocarditis. ( 28943190 )
2017
50
Sternoclavicular joint osteomyelitis extending to lung abscess complicated by Staphylococcal infective endocarditis. ( 28660126 )
2017

Variations for Infective Endocarditis

Expression for Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for Infective Endocarditis

Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 IL6 LBP SERPINE1 TLR2 TNF
2
Show member pathways
11.98 IL6 SERPINE1 TLR2 TNF
3
Show member pathways
11.94 IL6 ITGB3 TNF TNNI3
4 11.91 IL6 SERPINE1 TNF
5 11.89 FCGR2A ITGB3 TNF
6
Show member pathways
11.89 IL6 LBP TLR2 TNF
7
Show member pathways
11.89 CRP F2 IL6 SERPINE1 TNF
8 11.86 FCGR2A GP1BA ITGB3
9 11.85 FCGR2A IL6 TNF
10 11.82 IL6 LBP TNF
11 11.74 IL6 SERPINE1 TNF
12
Show member pathways
11.73 F2 GP1BA ITGB3
13 11.71 IL6 TLR2 TNF
14 11.67 IL6 TLR2 TNF
15
Show member pathways
11.63 CRP IL6 LBP
16 11.62 FCGR2A ITGB3 TLR2
17 11.61 GP1BA IL6 ITGB3 TNF
18 11.61 FCGR2A IL6 LBP TLR2 TNF
19 11.41 IL6 TLR2 TNF
20 11.34 IL6 TLR2 TNF
21 11.31 GP1BA IL6 TNF
22 11.09 FCGR2A GP1BA IL6 ITGB3 TNF
23 10.96 IL6 TNF
24 10.71 CRP IL6 TNF

GO Terms for Infective Endocarditis

Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 APOH CRP F2 FCGR2A GP1BA ITGB3
2 extracellular space GO:0005615 9.5 APOH CRP F2 IL6 LBP SERPINE1
3 cell surface GO:0009986 9.1 APOH GP1BA ITGB3 LBP TLR2 TNF

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.92 CRP IL6 TLR2 TNF
2 positive regulation of gene expression GO:0010628 9.91 CRP IL6 TLR2 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.88 GP1BA IL6 LBP TNF
4 cellular response to lipopolysaccharide GO:0071222 9.84 IL6 LBP SERPINE1 TNF
5 platelet activation GO:0030168 9.81 F2 GP1BA IL6 ITGB3
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL6 TLR2 TNF
7 platelet degranulation GO:0002576 9.78 APOH ITGB3 SERPINE1
8 defense response to Gram-negative bacterium GO:0050829 9.73 IL6 LBP SERPINE1
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 LBP TLR2 TNF
10 fibrinolysis GO:0042730 9.67 F2 GP1BA SERPINE1
11 positive regulation of interleukin-6 production GO:0032755 9.67 IL6 LBP TLR2 TNF
12 blood coagulation, intrinsic pathway GO:0007597 9.65 APOH F2 GP1BA
13 defense response to Gram-positive bacterium GO:0050830 9.65 CRP IL6 LBP TLR2 TNF
14 positive regulation of blood coagulation GO:0030194 9.63 APOH F2 SERPINE1
15 acute-phase response GO:0006953 9.62 CRP F2 IL6 LBP
16 regulation of blood coagulation GO:0030193 9.61 APOH F2 GP1BA
17 negative regulation of blood coagulation GO:0030195 9.6 APOH SERPINE1
18 negative regulation of growth of symbiont in host GO:0044130 9.59 LBP TNF
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.58 CRP ITGB3
20 negative regulation of fibrinolysis GO:0051918 9.58 APOH F2 SERPINE1
21 cellular response to lipoteichoic acid GO:0071223 9.57 LBP TLR2
22 opsonization GO:0008228 9.55 CRP LBP
23 positive regulation of interleukin-8 production GO:0032757 9.46 LBP SERPINE1 TLR2 TNF
24 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
25 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 ITGB3 TNF

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 ITGB3 SERPINE1 TNF
2 lipopeptide binding GO:0071723 8.96 LBP TLR2
3 lipopolysaccharide binding GO:0001530 8.8 F2 LBP TLR2

Sources for Infective Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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