MCID: INF034
MIFTS: 53

Infective Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Infective Endocarditis

MalaCards integrated aliases for Infective Endocarditis:

Name: Infective Endocarditis 12 74 52 58 15 71
Bacterial Endocarditis 58 17 71
Endocarditis, Infective 74 52
Infectious Endocarditis 58
Endocarditis Infective 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0060000
Orphanet 58 ORPHA570762
UMLS 71 C0014121 C1541923

Summaries for Infective Endocarditis

NIH Rare Diseases : 52 Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis . IE is caused by bacteria , fungi, or other germs invading the bloodstream and attaching to the heart. IE can damage the heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue .

MalaCards based summary : Infective Endocarditis, also known as bacterial endocarditis, is related to marantic endocarditis and mitral valve insufficiency, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Aminocaproic acid and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia : 74 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Infective Endocarditis

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 988)
# Related Disease Score Top Affiliating Genes
1 marantic endocarditis 33.4 F2 CRP APOH
2 mitral valve insufficiency 32.1 TNNI3 F2 CRP
3 congestive heart failure 31.8 TNNI3 TNF IL6 CRP
4 tricuspid valve insufficiency 31.6 TNNI3 F2 CRP
5 splenic infarction 31.4 F2 CRP APOH
6 osteomyelitis 31.4 TNF TLR2 IL6
7 cardiac tamponade 31.4 TNNI3 F2 CRP
8 pericardial effusion 31.3 TNNI3 IL6 F2 CRP
9 pericarditis 31.2 TNNI3 TNF IL6 CRP
10 rheumatic heart disease 31.2 TNF TLR2 IL6 CNMD
11 splenic abscess 31.2 F2 CRP
12 toxic shock syndrome 31.2 TREM1 TNF TLR2 LBP IL6 CRP
13 hemopericardium 31.2 TNNI3 F2
14 mitral valve disease 31.1 TNNI3 F2 CRP
15 rheumatic fever 31.1 TNF TLR2 IL6 FCGR2A
16 q fever 31.1 TNF TLR2 IL6
17 pulmonary edema 31.1 TNNI3 TNF F2 CRP
18 mitral valve stenosis 31.1 PPBP PF4 F2 CRP
19 exanthem 31.1 TNF IL6 F2 CRP
20 endophthalmitis 31.0 TNF TLR2 IL6 CRP
21 heart valve disease 31.0 TNNI3 F2 CRP CNMD APOH
22 acute cystitis 30.9 TNF TLR2 IL6 F2 CRP
23 vasculitis 30.9 TNF IL6 IL17A CRP APOH
24 pulmonary embolism 30.9 TNNI3 SERPINE1 PF4 GP1BA F2 CRP
25 disseminated intravascular coagulation 30.8 TNF SERPINE1 IL6 F2 CRP
26 bacteriuria 30.8 TLR2 IL6 CRP
27 haemophilus influenzae 30.8 TNF TLR2
28 pyelonephritis 30.8 TNF IL6 CRP
29 septic arthritis 30.8 TREM1 TNF TLR2 IL6 CRP
30 aortitis 30.8 TNF IL6 IL17A CRP
31 meningoencephalitis 30.8 TNF IL6 CRP
32 cellulitis 30.7 TNF IL6 IL17A CRP
33 endocarditis 30.7 TNNI3 TNF TLR6 TLR2 SERPINE1 PPBP
34 patent foramen ovale 30.7 TNNI3 SERPINE1 F2 CRP APOH
35 myocarditis 30.7 TNNI3 TNF IL6 IL17A
36 purpura 30.6 TNF IL6 GP1BA F2 CRP APOH
37 cerebritis 30.6 TNF CRP APOH
38 chlamydia 30.6 TNF TLR2 IL6 IL17A CRP
39 tricuspid valve disease 30.6 TNNI3 F2 CRP
40 pyuria 30.6 IL6 F2 CRP
41 spondylitis 30.6 TNF IL6 IL17A CRP
42 fasciitis 30.6 TNF IL6 CRP
43 cryoglobulinemia 30.6 TNF IL6 APOH
44 tularemia 30.6 TNF TLR2 IL17A
45 lung abscess 30.6 TNF IL6 CRP
46 brucellosis 30.6 TNF IL6 IL17A CRP
47 heart disease 30.5 TNNI3 TNF SERPINE1 PPBP PF4 IL6
48 typhoid fever 30.5 TNF IL6 F2 CRP
49 uremia 30.5 TNF PF4 IL6 CRP
50 periodontitis 30.5 TNF TLR2 IL6 IL17A CRP

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to Infective Endocarditis

Symptoms & Phenotypes for Infective Endocarditis

UMLS symptoms related to Infective Endocarditis:


osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 AQP9 CNMD F2 FCGR2A GP1BA IBSP
2 homeostasis/metabolism MP:0005376 9.8 APOH AQP9 CNMD CRP F2 GP1BA
3 immune system MP:0005387 9.47 AQP9 CNMD CRP F2 FCGR2A IBSP

Drugs & Therapeutics for Infective Endocarditis

Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
8
Vancomycin Approved Phase 4 1404-90-6 14969 441141
9
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
10
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
11
Hexetidine Approved, Investigational Phase 4 141-94-6
12
Norepinephrine Approved Phase 4 51-41-2 439260
13
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
14
Dobutamine Approved Phase 4 34368-04-2 36811
15
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
16
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
17
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
18
Racepinephrine Approved Phase 4 329-65-7 838
19
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
20
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
21
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
22
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
23
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
24
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
25
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
26
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
27
Simendan Investigational Phase 4 131741-08-7
28 Analgesics, Non-Narcotic Phase 4
29 Analgesics Phase 4
30 Hemostatics Phase 4
31 Anticoagulants Phase 4
32 Anti-Inflammatory Agents Phase 4
33 Antipyretics Phase 4
34 Antifibrinolytic Agents Phase 4
35 Coagulants Phase 4
36 Methylprednisolone Acetate Phase 4
37 Hormones Phase 4
38 Antineoplastic Agents, Hormonal Phase 4
39 glucocorticoids Phase 4
40 Neuroprotective Agents Phase 4
41 Hormone Antagonists Phase 4
42 Adrenergic alpha-Agonists Phase 4
43 Anesthetics Phase 4
44 Adrenergic Agents Phase 4
45 Adrenergic Agonists Phase 4
46 Hypnotics and Sedatives Phase 4
47 Neurotransmitter Agents Phase 4
48 Cephalosporins Phase 4
49 Dermatologic Agents Phase 4
50 Chlorhexidine gluconate Phase 4

Interventional clinical trials:

(show top 50) (show all 133)
# Name Status NCT ID Phase Drugs
1 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 Randomized Clinical Trial to Verify the Effectiveness of Topical Aminocaproic Acid in the Prevention of Post-exodontic Bleeding in Patients on Anticoagulants Unknown status NCT02238288 Phase 4 Aminocaproic acid;lidocaine and epinephrine;Paracetamol
4 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
5 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
6 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
7 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
8 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
9 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
10 A Comparative Evaluation of the Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects One - Seventeen Years of Age With Bacteremia Caused by Staphylococcus Aureus. Completed NCT01728376 Phase 4 Daptomycin;Comparator
11 The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery. Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
12 Bacteraemia Secondary to Tooth Extraction: a Randomized Clinical Trial on Efficacy of Three Different Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
13 Comparative Study of Hemodynamic Changes Caused by Diazepam and Midazolam During Third Molar Surgery. A Prospective Randomized Study Completed NCT02177955 Phase 4 7.5 mg Midazolam;10 mg diazepam
14 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
15 A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus Aureus Infections in Patients With Opioid Use Disorder Recruiting NCT03761953 Phase 4 Oritavancin Injection
16 Short-course Antibiotic Regimen Compared to Conventional Antibiotic Treatment for Gram-positive Cocci Infective Endocarditis: Randomized Clinical Trial Not yet recruiting NCT04222257 Phase 4 Antibiotics;Antibiotics
17 Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus Not yet recruiting NCT03632642 Phase 4 Benzylpenicillin;Flucloxacillin
18 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
19 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
20 Effect of Rituximab in Treatment of Primary Membranoproliferative Glomerulonephritis Unknown status NCT03180723 Phase 3 Rituximab;Cyclosporin
21 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
22 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
23 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
24 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
25 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
26 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
27 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Recruiting NCT04160468 Phase 3 Exebacase;Placebo
28 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
29 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
30 Evaluation de la rhAnnexine V-128 radiomarquée Dans le Diagnostic de l'Endocardite Infectieuse, du Thrombus Atrial et de Leurs Complications Emboliques associées Unknown status NCT02459613 Phase 1, Phase 2
31 A Randomized Study of the Effects of Perioperative i.v. Ketorolac-lidocaine on the Hemodynamic Response in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
32 Bacteremia From Dental Extractions vs. Oral Hygiene Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
33 Phase II Clinical Trial to Evaluate an Antibiotic Regimen Pharmacokinetic Applicable to Outpatient Parenteral Antimicrobial Therapy in Enterococcus Faecalis Infective Endocarditis Active, not recruiting NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
34 Phase 2, Open-Label, Randomized, Multicenter Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Documented Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
35 A Phase 2 Multicenter, Randomized, Double-blinded, Study to Describe the Safety, Efficacy, and Pharmacokinetics of Daptomycin 10 mg/kg/Day and Vancomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
36 A Multi-centre Open Label Randomized Controlled Phase IIB Trial Comparing Vancomycin Versus Daptomycin for the Treatment of MRSA Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
37 Clinical, Histological and Micro-computed Tomographic Evaluation of Neoformed Tissue in Post-extraction Sockets Covered With Platelet-rich Fibrin (PRF) Membrane: a Randomized Controlled Trial Unknown status NCT02300246 Phase 1
38 The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers (SEARCH PK) Completed NCT03831971 Phase 1 ANS-6637
39 Dose-Ranging, Safety And Efficacy Of Cathflo(TM) Activase(R) (Alteplase) For The Treatment Of Central Catheter Occlusion In Neonates And Infants; Phase I Terminated NCT00265005 Phase 1 alteplase
40 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
41 Beta-lactam Pharmacokinetic Profiles in Patients With Infective Endocarditis Unknown status NCT02033421
42 Etiology of Endocarditis in Negative Blood Cultures Unknown status NCT02816307
43 Detection of the Most Common Micro Organism of Infective Endocarditis in Assiut University Hospital Unknown status NCT03487653
44 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
45 The Use of Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
46 Study of Autoantibodies in Infective Endocarditis Unknown status NCT00562653
47 Impact of Setting up a Multidisciplinary Consensus Meeting in the Prognosis and Management of Infectious Endocarditis at Strasbourg University Hospital. Unknown status NCT03429153
48 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Unknown status NCT02887079
49 Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis Unknown status NCT02252900
50 Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiovascular Implantable Electronic Device Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

Anatomical Context for Infective Endocarditis

MalaCards organs/tissues related to Infective Endocarditis:

40
Heart, Brain, Kidney, Liver, Endothelial, Colon, Skin

Publications for Infective Endocarditis

Articles related to Infective Endocarditis:

(show top 50) (show all 15400)
# Title Authors PMID Year
1
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]. 54 61
17339740 2007
2
Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. 54 61
16980969 2006
3
Metabolism of glycoprotein-derived sialic acid and N-acetylglucosamine by Streptococcus oralis. 54 61
8704962 1996
4
Asymptomatic bilateral obstructing ureteric calculi resulting in Lactobacillaemia and endocarditis requiring emergency aortic valve replacement. 61
32373471 2020
5
Widespread septic embolization in injection drug use mitro-aortic infective endocarditis as a remote cause of death. 61
32367331 2020
6
Right sinus of Valsalva aneurysm. 61
32145675 2020
7
The biofilm-associated bacterial infections unrelated to indwelling devices. 61
32150327 2020
8
Kodamaea ohmeri infections in humans: A systematic review. 61
32323385 2020
9
Non-infective endocarditis. 61
32376608 2020
10
Right-Sided Infective Endocarditis. 61
32509980 2020
11
Evolving Spectrum of Prognostic Inflammatory Markers in Infective Endocarditis. 61
32147322 2020
12
Mechanical Versus Biologic Prostheses for Surgical Aortic Valve Replacement in Patients Aged 50 to 70. 61
31786289 2020
13
Prosthetic valve endocarditis following transcatheter aortic valve implantation. 61
32332380 2020
14
Quantification of Multiple Bacteria in Calcified Structural Valvular Heart Disease. 61
31605771 2020
15
Incidence and Surgical Outcomes of Patients With Native and Prosthetic Aortic Valve Endocarditis. 61
31794735 2020
16
Incidence Trends, Comorbidities, and Outcomes of Pyogenic Liver Abscess Among Children: A Nationwide Population-based Analysis. 61
32142002 2020
17
Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure. 61
31822570 2020
18
Disturbing effect of lockdown for COVID-19 on the incidence of infective endocarditis: a word of caution. 61
32524195 2020
19
Short-course antibiotic regimen compared to conventional antibiotic treatment for gram-positive cocci infective endocarditis: randomized clinical trial (SATIE). 61
32546269 2020
20
Infective endocarditis in the Netherlands: current epidemiological profile and mortality : An analysis based on partial ESC EORP collected data. 61
32504340 2020
21
Diagnosis of Infective Endocarditis by Subtype Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: A Contemporary Meta-Analysis. 61
32507019 2020
22
The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark. 61
32289560 2020
23
Corrigendum to: Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. 61
31682254 2020
24
18F-FDG PET/CT in the diagnosis of cardiac device-related infective endocarditis. 61
32557151 2020
25
Safety and Efficacy of Thrombolysis and Mechanical Thrombectomy in Infective Endocarditis. 61
32205025 2020
26
A rare cause of infective endocarditis and stroke: Filamentous vegetation due to Granulicatella adiacens. 61
32504799 2020
27
Extensive cutaneous necrosis in infective endocarditis: do not forget rare causes. 61
31872234 2020
28
Contribution of Severe Dental Caries Induced by Streptococcus mutans to the Pathogenicity of Infective Endocarditis. 61
32312765 2020
29
A Shortcut to Death: Aorto-Left Atrial Fistula in the Setting of MRSA Infective Endocarditis. 61
32577604 2020
30
Radiolabeled-White Blood Cell Imaging in Cardiac Device-Related Infective Endocarditis: Worth All the Effort? 61
32563659 2020
31
Comparison Between ESC and Duke Criteria for the Diagnosis of Prosthetic Valve Infective Endocarditis. 61
32563658 2020
32
Clinical outcomes for congenital heart disease patients presenting with infective endocarditis. 61
32476525 2020
33
Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components. 61
32544089 2020
34
Contemporary Trends in Native Valve Infective Endocarditis in United States (from the National Inpatient Sample Database). 61
32278463 2020
35
Inappropriate use of antibiotics in primary care for patients with infective endocarditis. 61
32197818 2020
36
Bioprosthetic vs mechanical mitral valve replacement for infective endocarditis in patients aged 50 to 69 years. 61
32497339 2020
37
Recurrent infective endocarditis in a patient after a second Melody valve placement. 61
32498746 2020
38
Correction to: Infective Endocarditis After Transcatheter Aortic Valve Implantation: Results From a Large Multicenter Registry. 61
32479197 2020
39
Systematic Whole Body 18F-FDG PET/CT in Infective Endocarditis: Are We There Yet? 61
32479617 2020
40
Low diagnostic yield of funduscopy in the evaluation of a patient with suspected infective endocarditis. 61
31125071 2020
41
Association between biomass formation and the prognosis of infective endocarditis due to Staphylococcus aureus. 61
31806416 2020
42
Reply: The Need for Quality and Unbiased Data in Infective Endocarditis. 61
32527408 2020
43
Epidemiology of infective endocarditis in transcatheter aortic valve replacement: systemic review and meta-analysis. 61
32520865 2020
44
Cogan syndrome: Descriptive analysis and clinical experience of 7 cases diagnosed and treated in two third level hospitals. 61
32571733 2020
45
Three cusps are better than two: bicuspid aortic valve and implications for military service. 61
30429296 2020
46
Simultaneous aortic valve endocarditis and mycotic pseudoaneurysm of aortic coarctation. 61
32557775 2020
47
Incidental diagnosis of a large aortopulmonary window with reversible pulmonary arterial hypertension in adult age and its surgical management. 61
32306468 2020
48
"Noninfective Endocarditis": A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male. 61
32521783 2020
49
Cardiac and Pulmonary Disorders and the Nervous System. 61
32487896 2020
50
Surgical Options for Aortic Root Replacement in Destructive Endocarditis. 61
32549097 2020

Variations for Infective Endocarditis

Expression for Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for Infective Endocarditis

Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TREM1 TNF TLR6 TLR2 PPBP LBP
2
Show member pathways
13.16 TREM1 SERPINE1 PPBP PF4 GP1BA F2
3
Show member pathways
12.89 TREM1 TNF TLR6 TLR2 SERPINE1 LBP
4
Show member pathways
12.64 TNF TLR6 TLR2 SERPINE1 IL6
5
Show member pathways
12.62 TNF TLR6 TLR2 PPBP IL6
6
Show member pathways
12.26 TNF TLR2 IL6 IL17A
7
Show member pathways
12.25 TNF PPBP PF4 IL6
8 12.23 TNF TLR6 TLR2 IL6
9 12.18 TNF IL6 FCGR2A F2
10
Show member pathways
12.16 TNF TLR6 TLR2 IL6
11
Show member pathways
12.12 TREM1 PF4 F2 CEACAM8
12
Show member pathways
12.1 TNF SERPINE1 IL6 F2 CRP
13 12.07 TNF TLR6 TLR2 IL6
14
Show member pathways
12.03 SERPINE1 PF4 GP1BA F2
15
Show member pathways
11.87 TNF TLR6 TLR2 LBP IL6
16 11.85 TNF LBP IL6 IL17A
17
Show member pathways
11.75 LBP IL6 CRP
18 11.74 TLR6 TLR2 FCGR2A
19 11.7 TNF TLR2 IL6 IL17A
20
Show member pathways
11.66 TLR6 TLR2 IL6 IL17A
21 11.62 TNF IL6 GP1BA FCGR2A CEACAM8
22 11.51 TNF TLR2 IL6
23 11.43 TNF TLR2 IL6
24 11.39 TNF IL6 GP1BA
25
Show member pathways
11.38 TNF TLR6 TLR2 IL6 IL17A
26 11.36 TNF TLR6 TLR2 LBP IL6 FCGR2A
27 11.19 TNF IL6 IL17A
28 10.78 TNF IL6 CRP

GO Terms for Infective Endocarditis

Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TREM1 TNF SERPINE1 PPBP PF4 LBP
2 cell surface GO:0009986 9.63 TNF TLR2 LBP GP1BA CEACAM8 APOH
3 extracellular space GO:0005615 9.44 TNF SERPINE1 PPBP PF4 LBP IL6
4 platelet alpha granule lumen GO:0031093 9.43 SERPINE1 PPBP PF4

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.06 TNF TLR6 TLR2 PF4 IL6 CRP
2 cytokine-mediated signaling pathway GO:0019221 10.01 TNF PF4 LBP IL6 IL17A
3 leukocyte migration GO:0050900 9.96 TREM1 TNF F2 CEACAM8
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR6 TLR2 IL6
5 platelet degranulation GO:0002576 9.91 SERPINE1 PPBP PF4 APOH
6 platelet activation GO:0030168 9.88 PF4 IL6 GP1BA F2
7 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.85 PPBP PF4 F2
8 humoral immune response GO:0006959 9.83 TREM1 TNF IL6
9 positive regulation of tumor necrosis factor production GO:0032760 9.83 TLR2 PF4 LBP
10 defense response to Gram-positive bacterium GO:0050830 9.83 TNF TLR2 LBP IL6 CRP
11 toll-like receptor signaling pathway GO:0002224 9.82 TLR6 TLR2 LBP
12 positive regulation of interleukin-6 secretion GO:2000778 9.81 TNF TLR2 IL17A
13 negative regulation of endothelial cell proliferation GO:0001937 9.8 TNF CNMD APOH
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR2 LBP
15 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR2 LBP IL6
16 cellular response to lipopolysaccharide GO:0071222 9.8 TNF SERPINE1 PPBP PF4 LBP IL6
17 positive regulation of JAK-STAT cascade GO:0046427 9.77 TNF IL6 F2
18 microglial cell activation GO:0001774 9.77 TNF TLR6 TLR2
19 immune response GO:0006955 9.76 TNF TLR6 TLR2 PPBP PF4 IL6
20 fibrinolysis GO:0042730 9.72 SERPINE1 GP1BA F2
21 blood coagulation, intrinsic pathway GO:0007597 9.71 GP1BA F2 APOH
22 acute-phase response GO:0006953 9.71 LBP IL6 F2 CRP
23 positive regulation of blood coagulation GO:0030194 9.7 SERPINE1 F2 APOH
24 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL6
25 regulation of blood coagulation GO:0030193 9.69 GP1BA F2 APOH
26 regulation of cytokine secretion GO:0050707 9.68 TLR6 TLR2
27 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 LBP
28 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.68 TNF IL17A
29 opsonization GO:0008228 9.68 LBP CRP
30 cellular response to bacterial lipopeptide GO:0071221 9.67 TLR6 TLR2
31 negative regulation of vascular wound healing GO:0061044 9.67 TNF SERPINE1
32 positive regulation of interleukin-8 production GO:0032757 9.67 TNF TLR2 SERPINE1 LBP
33 cellular response to diacyl bacterial lipopeptide GO:0071726 9.65 TLR6 TLR2
34 negative regulation of fibrinolysis GO:0051918 9.65 SERPINE1 F2 APOH
35 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.63 TLR6 TLR2
36 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
37 nitric oxide metabolic process GO:0046209 9.62 TLR6 TLR2
38 detection of diacyl bacterial lipopeptide GO:0042496 9.57 TLR6 TLR2
39 response to bacterial lipoprotein GO:0032493 9.56 TLR6 TLR2
40 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.56 TNF TLR6 IL6 IL17A
41 positive regulation of chemokine production GO:0032722 9.26 TNF TLR2 LBP IL6
42 inflammatory response GO:0006954 9.23 TNF TLR6 TLR2 PPBP PF4 IL6

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF PPBP PF4 IL6 IL17A
2 lipopolysaccharide binding GO:0001530 9.33 TLR2 LBP F2
3 lipopeptide binding GO:0071723 8.8 TLR6 TLR2 LBP

Sources for Infective Endocarditis

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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