MCID: INF034
MIFTS: 53

Infective Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Infective Endocarditis

MalaCards integrated aliases for Infective Endocarditis:

Name: Infective Endocarditis 12 75 53 15 72
Endocarditis, Infective 75 53
Endocarditis Infective 55
Bacterial Endocarditis 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0060000
UMLS 72 C0014121 C1541923

Summaries for Infective Endocarditis

NIH Rare Diseases : 53 Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. IE is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damage the heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.

MalaCards based summary : Infective Endocarditis, also known as endocarditis, infective, is related to cardiogenic shock and toxic shock syndrome, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Acetaminophen and Aminocaproic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and endothelial, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia : 75 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Infective Endocarditis

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 674)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 31.2 TNF IL6
2 toxic shock syndrome 31.2 TNF TLR2 IL6
3 pericarditis 30.9 TNF IL6 CRP
4 pulmonary edema 30.9 TNF F2 CRP
5 end stage renal failure 30.9 TNF IL6 CRP
6 exanthem 30.8 TNF IL6 CRP
7 acute myocardial infarction 30.8 TNNI3 SERPINE1 CRP
8 endocarditis 30.7 TNNI3 TNF TLR2 LBP IL6 FCGR2A
9 vasculitis 30.7 TNF CRP APOH
10 relapsing fever 30.7 TNF CRP
11 q fever 30.6 TNF TLR2 IL6
12 spondylitis 30.4 TNF IL6 CRP
13 pyelonephritis 30.4 TNF IL6 CRP
14 brucellosis 30.4 TNF IL6 CRP
15 myocarditis 30.4 TNNI3 TNF IL6
16 stroke, ischemic 30.4 SERPINE1 F2 CRP APOH
17 pulmonary embolism 30.4 TNNI3 SERPINE1 F2 CRP APOH
18 mastitis 30.3 TLR2 LBP IL6
19 neutrophilia, hereditary 30.3 IL6 CRP
20 haemophilus influenzae 30.3 TNF TLR2
21 cerebrovascular disease 30.3 TNF SERPINE1 IL6 F2 CRP
22 chlamydia 30.2 TNF TLR2 IL6 CRP
23 periodontitis, chronic 30.2 TLR2 IL6
24 limb ischemia 30.2 TNNI3 TNF IL6
25 peripheral vascular disease 30.2 SERPINE1 IL6 F2 CRP
26 intermediate coronary syndrome 30.2 TNNI3 IL6 CRP
27 kawasaki disease 30.2 TNF IL6 FCGR2A CRP
28 autoimmune myocarditis 30.1 TNF IL6
29 thrombophlebitis 30.1 SERPINE1 F2 APOH
30 periodontitis 30.1 TNF TLR2 IL6 CRP
31 streptococcal toxic-shock syndrome 30.1 TNF IL6
32 ulcerative colitis 30.1 TNF IL6 CRP
33 trench fever 30.1 TNF TLR2
34 thrombophilia 30.1 SERPINE1 F2 APOH
35 thrombocytopenia 30.0 ITGB3 GP1BA APOH
36 rheumatic disease 30.0 TNF CRP APOH
37 viral hepatitis 30.0 TNF TLR2 F2
38 bacterial infectious disease 30.0 TNF TLR2 LBP IL6 CRP
39 typhoid fever 30.0 TNF IL6 F2 CRP
40 adult-onset still's disease 29.9 TNF IL6 CRP
41 coronary artery anomaly 29.9 TNNI3 SERPINE1 F2 CRP
42 bacterial meningitis 29.9 TNF TLR2 IL6 CRP
43 otitis media 29.9 TNF TLR2 IL6
44 gastroenteritis 29.9 TNF IL6 CRP
45 bone inflammation disease 29.9 TNF IL6 CRP
46 sleep apnea 29.9 TNF IL6 CRP
47 bronchiolitis 29.9 TNF IL6 CRP
48 appendicitis 29.8 TNF LBP IL6 CRP
49 synovitis 29.8 TNF IL6 CRP
50 mouth disease 29.8 TNF IL6 CRP

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to Infective Endocarditis

Symptoms & Phenotypes for Infective Endocarditis

UMLS symptoms related to Infective Endocarditis:


osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.11 CD36 F2 FCGR2A GP1BA IL6 ITGB3
2 cardiovascular system MP:0005385 10.09 CD36 CRP F2 IL6 ITGB3 SERPINE1
3 homeostasis/metabolism MP:0005376 10.06 APOH CD36 CRP F2 GP1BA IL6
4 immune system MP:0005387 10 CD36 CRP F2 FCGR2A IL6 ITGB3
5 digestive/alimentary MP:0005381 9.88 CD36 F2 IL6 ITGB3 TLR2 TNF
6 liver/biliary system MP:0005370 9.7 CD36 IL6 ITGB3 LBP SERPINE1 TLR2
7 mortality/aging MP:0010768 9.65 APOH CD36 F2 FCGR2A IL6 ITGB3
8 respiratory system MP:0005388 9.17 F2 IL6 ITGB3 SERPINE1 TLR2 TNF

Drugs & Therapeutics for Infective Endocarditis

Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 158)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
3
Fosfomycin Approved Phase 4 23155-02-4 446987
4
Vancomycin Approved Phase 4 1404-90-6 441141 14969
5
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
6
Hexetidine Approved, Investigational Phase 4 141-94-6
7
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
8
Norepinephrine Approved Phase 4 51-41-2 439260
9
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
10
Racepinephrine Approved Phase 4 329-65-7 838
11
Dobutamine Approved Phase 4 34368-04-2 36811
12
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
15
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
16
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
17
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
18
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
19
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
20 Simendan Investigational Phase 4 131741-08-7
21 Analgesics Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Hemostatics Phase 4
24 Coagulants Phase 4
25 Anticoagulants Phase 4
26 Antifibrinolytic Agents Phase 4
27 Antipyretics Phase 4
28 Neurotransmitter Agents Phase 4
29 Adrenergic Agonists Phase 4
30 Adrenergic alpha-Agonists Phase 4
31 Central Nervous System Depressants Phase 4
32 Peripheral Nervous System Agents Phase 4
33 Adrenergic Agents Phase 4
34 Hypnotics and Sedatives Phase 4
35 Anesthetics Phase 4
36 Cephalosporins Phase 4
37 Dermatologic Agents Phase 4
38 Disinfectants Phase 4
39 Chlorhexidine gluconate Phase 4
40 Anti-Infective Agents, Local Phase 4
41 Sympathomimetics Phase 4
42 Cardiotonic Agents Phase 4
43 Adrenergic beta-Agonists Phase 4
44 Epinephryl borate Phase 4
45 Phosphodiesterase Inhibitors Phase 4
46 Protective Agents Phase 4
47 Vasodilator Agents Phase 4
48 Autonomic Agents Phase 4
49 Phosphodiesterase 3 Inhibitors Phase 4
50 Anesthetics, Local Phase 4

Interventional clinical trials:

(show top 50) (show all 115)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
2 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
3 Randomized Clinical Trial to Verify the Effectiveness of Topical Aminocaproic Acid in the Prevention of Post-exodontic Bleeding in Patients on Anticoagulants Unknown status NCT02238288 Phase 4 Aminocaproic acid;lidocaine and epinephrine;Paracetamol
4 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
5 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
6 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
7 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
8 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
9 A Comparative Evaluation of the Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects One - Seventeen Years of Age With Bacteremia Caused by Staphylococcus Aureus. Completed NCT01728376 Phase 4 Daptomycin;Comparator
10 The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery. Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
11 Bacteraemia Secondary to Tooth Extraction: a Randomized Clinical Trial on Efficacy of Three Different Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
12 Comparative Study of Hemodynamic Changes Caused by Diazepam and Midazolam During Third Molar Surgery. A Prospective Randomized Study Completed NCT02177955 Phase 4 7.5 mg Midazolam;10 mg diazepam
13 Does Whole Blood Adsorber During CPB Reduce the Amount of Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery? -a Randomized Controlled Study Recruiting NCT03945708 Phase 4
14 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
15 Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus Not yet recruiting NCT03632642 Phase 4 Benzylpenicillin;Flucloxacillin
16 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
17 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
18 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
19 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
20 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
21 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
22 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
23 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
24 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
25 Effect of Rituximab in Treatment of Primary Membranoproliferative Glomerulonephritis Not yet recruiting NCT03180723 Phase 3 Rituximab;Cyclosporin
26 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
27 A Randomized Study of the Effects of Perioperative i.v. Ketorolac-lidocaine on the Hemodynamic Response in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
28 Bacteremia From Dental Extractions vs. Oral Hygiene Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
29 Evaluation de la rhAnnexine V-128 radiomarquée Dans le Diagnostic de l'Endocardite Infectieuse, du Thrombus Atrial et de Leurs Complications Emboliques associées Recruiting NCT02459613 Phase 1, Phase 2
30 Phase II Clinical Trial to Evaluate an Antibiotic Regimen Pharmacokinetic Applicable to Outpatient Parenteral Antimicrobial Therapy in Enterococcus Faecalis Infective Endocarditis Active, not recruiting NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
31 Phase 2, Open-Label, Randomized, Multicenter Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Documented Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
32 A Phase 2 Multicenter, Randomized, Double-blinded, Study to Describe the Safety, Efficacy, and Pharmacokinetics of Daptomycin 10 mg/kg/Day and Vancomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
33 A Multi-centre Open Label Randomized Controlled Phase IIB Trial Comparing Vancomycin Versus Daptomycin for the Treatment of MRSA Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
34 Clinical, Histological and Micro-computed Tomographic Evaluation of Neoformed Tissue in Post-extraction Sockets Covered With Platelet-rich Fibrin (PRF) Membrane: a Randomized Controlled Trial Unknown status NCT02300246 Phase 1
35 Dose-Ranging, Safety And Efficacy Of Cathflo(TM) Activase(R) (Alteplase) For The Treatment Of Central Catheter Occlusion In Neonates And Infants; Phase I Terminated NCT00265005 Phase 1 alteplase
36 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
37 Beta-lactam Pharmacokinetic Profiles in Patients With Infective Endocarditis Unknown status NCT02033421
38 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
39 The Use of Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
40 Study of Autoantibodies in Infective Endocarditis Unknown status NCT00562653
41 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Unknown status NCT02887079
42 Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiovascular Implantable Electronic Device Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
43 Clinical Metagenomics of Infective Endocarditis Unknown status NCT03199287
44 Individualized Diagnosis of Endocarditis and Its Therapy With a Focus on Infected Prosthetic materiAL Unknown status NCT02759978
45 Effectiveness And Safety of LMWH Treatment in Cancer Patients Diagnosed With Non-High Risk Venous Thromboembolism - An Observational Study Unknown status NCT02017743
46 Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis Unknown status NCT02252900
47 The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve Unknown status NCT02713932
48 Treatment of Chorioamnionitis After Delivery Unknown status NCT00814905 saline;ampicillin gentamicin;Ampicillin gentamicin clindamycin;ampicillin gentamicin clindamycin
49 Infective Endocarditis in the Elderly: Description of the Geriatric Characteristics and Their Influence on Therapeutic Care and the Morbidity and Mortality at 3 Months (ELDERL-IE) Completed NCT02910856
50 Evolution of the Profile of Infectious Endocarditis in France in 2008 Completed NCT03295045

Search NIH Clinical Center for Infective Endocarditis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Amoxicillin
Cefazolin
Ceftriaxone
Clarithromycin
Clindamycin
Metronidazole
Phenoxymethylpenicillin
Sulbactam

Genetic Tests for Infective Endocarditis

Anatomical Context for Infective Endocarditis

MalaCards organs/tissues related to Infective Endocarditis:

41
Heart, Brain, Endothelial, Kidney, Colon, Liver, Skin

Publications for Infective Endocarditis

Articles related to Infective Endocarditis:

(show top 50) (show all 10259)
# Title Authors PMID Year
1
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]. 9 38
17339740 2007
2
Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. 9 38
16980969 2006
3
Metabolism of glycoprotein-derived sialic acid and N-acetylglucosamine by Streptococcus oralis. 9 38
8704962 1996
4
A case of infective endocarditis associated with atopic dermatitis perioperatively treated with dupilumab. 38
30628496 2019
5
Surgical treatment of isolated tricuspid valve infective endocarditis: 25-year results from a multicenter registry. 38
31130281 2019
6
Characterization, epidemiological profile and risk factors for clinical outcome of infective endocarditis from a tertiary care centre in Turkey. 38
31364901 2019
7
Contemporary epidemiology of infective endocarditis in patients with congenital heart disease: A UK prospective study. 38
31299559 2019
8
Does gender affect the prognosis and risk of complications in patients with congenital heart disease in the modern era? 38
31085083 2019
9
Candida tropicalis defibrillator endocarditis: A case report and review of current literature. 38
31245269 2019
10
A Case of Mitral Valve Endocarditis Complicated by Multiple Embolic Phenomena: Leaping from Adult Guidelines to Pediatric Critical Care Decisions. 38
31404392 2019
11
[Febrile myalgia revealing Propionibacterium acnes endocarditis]. 38
31229357 2019
12
Portraying infective endocarditis: results of multinational ID-IRI study. 38
31187307 2019
13
Clinical characteristics and treatment outcomes of Enterococcus durans bacteremia: a 20-year experience in a tertiary care hospital. 38
31243595 2019
14
Contribution of hla Regulation by SaeR to Staphylococcus aureus USA300 Pathogenesis. 38
31209148 2019
15
The risk of infective endocarditis following interventional pulmonary valve implantation: A meta-analysis. 38
31113702 2019
16
Prosthetic Aortic Valve Endocarditis in a Patient With Birt-Hogg-Dube Syndrome due to Lactobacillus paracasei. 38
31413783 2019
17
Early transthoracic echocardiography has useful prognostic value in left-sided native valve endocarditis despite limited diagnostic performance. 38
31140069 2019
18
Mitral Valve Endocarditis: A Rare Manifestation of Lyme Disease. 38
30690018 2019
19
Recurrent lung nodules as a presentation of ventricular septal defect-related endocarditis. 38
31168368 2019
20
Clinical course of infectious intracranial aneurysm undergoing antibiotic treatment. 38
31220742 2019
21
High-dose trimethoprim-sulfamethoxazole and clindamycin for Staphylococcus aureus endocarditis. 38
31181351 2019
22
Immunosuppressive therapy to reduce mitral regurgitation in Libman-Sacks endocarditis: a case report. 38
31377769 2019
23
Effect of conjugated bilirubin on clinical outcomes in infective endocarditis. 38
31428896 2019
24
Infective endocarditis in elderly and very elderly patients. 38
31429005 2019
25
Rapid diagnosis of infective endocarditis using pocket size ultrasound. 38
31419418 2019
26
Mitral valve repair versus replacement for infective endocarditis, again. 38
30885627 2019
27
Infective endocarditis after transcatheter aortic valve implantation: a nationwide study. 38
31433472 2019
28
Sex matters: impact of sex on surgery for infective endocarditis. 38
31400335 2019
29
Infective endocarditis: New forms of the disease, new therapeutic options. 38
31109642 2019
30
Diagnostic challenges in infective endocarditis: is PET/CT the solution? 38
30847769 2019
31
Combination Antimicrobial Therapy for Enterococcus faecalis Infective Endocarditis. 38
30715308 2019
32
Unusual Aorto-mitral Discontinuity Caused by Infective Endocarditis. 38
31118390 2019
33
Infective endocarditis in patients with cardiac implantable electronic devices: Impact of comorbidities on outcome. 38
31280907 2019
34
Multisystem organ failure secondary to Haemophilus parainfluenzae infective endocarditis on an ICD lead: A case report. 38
31109781 2019
35
[Mycotic Aneurysm of the Ulnar Artery Associated with Infective Endocarditis;Report of a Case]. 38
31353355 2019
36
Long-term prognosis after surgery for infective endocarditis: Distinction between predictors of early and late survival. 38
30470460 2019
37
Comparison of Neutropenia Associated with Ceftaroline or Ceftriaxone in Patients Receiving at Least 7 Days of Therapy for Severe Infections. 38
31257604 2019
38
Ten-year Experience of Q Fever Endocarditis in a Tertiary Cardiac Center in Saudi Arabia. 38
31382048 2019
39
Multi-organ embolism caused by oscillating aortic valve vegetation: A case report. 38
31374023 2019
40
[Clinical features and prognosis of infective endocarditis patients with acute kidney injury]. 38
31420632 2019
41
Infective endocarditis: Beyond the usual tests. 38
31385793 2019
42
Prediction of Acute-phase Complications in Patients with Infectious Endocarditis. 38
31118367 2019
43
Outcome of early vs delayed surgery for infective mitral endocarditis. 38
31269271 2019
44
The utility of inflammatory markers in diagnostic work-up of pacemaker and defibrillator infections in patients referred for transvenous lead extraction. 38
31424054 2019
45
Knowledge of antibiotics and antimicrobial resistance amongst final year dental students of Polish medical schools-A cross-sectional study. 38
30729642 2019
46
Prognosis of Streptococcus pneumoniae endocarditis in France, a multicenter observational study (2000-2015). 38
31056415 2019
47
Endocarditis Caused by Highly Penicillin-Resistant Viridans Group Streptococci: Still Room for Vancomycin-Based Regimens. 38
31182540 2019
48
Daptomycin-containing regimens for treatment of gram-positive endocarditis. 38
31400470 2019
49
Oral Health in Adults with Congenital Heart Disease. 38
31430933 2019
50
Should High-dose Daptomycin be an Alternative Treatment Regimen for Enterococcal Endocarditis? 38
31428940 2019

Variations for Infective Endocarditis

Expression for Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for Infective Endocarditis

Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 TNF TLR6 TLR2 LBP ITGB3 IL6
2
Show member pathways
13.2 SERPINE1 ITGB3 GP1BA F2 CD36 APOH
3
Show member pathways
12.96 TNF TLR6 TLR2 SERPINE1 LBP IL6
4
Show member pathways
12.59 TNF TLR6 TLR2 IL6
5
Show member pathways
12.52 TNF TLR6 TLR2 LBP ITGB3
6
Show member pathways
12.3 TLR6 TLR2 LBP ITGB3
7
Show member pathways
12.21 TNF SERPINE1 IL6 F2 CRP
8
Show member pathways
12.14 TNNI3 TNF ITGB3 IL6
9
Show member pathways
12.13 TNF TLR6 TLR2 IL6 CD36
10
Show member pathways
12.12 TNF TLR2 SERPINE1 IL6
11 12.08 TNF TLR6 TLR2 IL6
12
Show member pathways
12.05 TNF TLR6 TLR2 LBP IL6
13 11.99 TNF TLR6 TLR2 LBP IL6 FCGR2A
14 11.98 TLR6 TLR2 ITGB3 FCGR2A CD36
15 11.97 TNF SERPINE1 IL6
16 11.95 TNF ITGB3 FCGR2A
17
Show member pathways
11.95 TNF TLR6 TLR2 IL6
18 11.93 ITGB3 GP1BA FCGR2A
19 11.91 TNF IL6 FCGR2A
20 11.88 TNF LBP IL6 CD36
21
Show member pathways
11.86 TNF IL6 CD36
22 11.81 TNF SERPINE1 IL6
23 11.81 TNF TLR2 IL6
24
Show member pathways
11.8 ITGB3 GP1BA F2
25 11.76 TNF TLR2 IL6
26 11.73 TLR6 TLR2 ITGB3 FCGR2A
27
Show member pathways
11.72 LBP IL6 CRP
28 11.71 TNF ITGB3 IL6 GP1BA CD36
29 11.53 TNF TLR2 IL6
30 11.5 TNF ITGB3 IL6 GP1BA FCGR2A CD36
31 11.48 ITGB3 F2 CD36
32 11.44 TNF IL6 GP1BA
33 11.4 TNF ITGB3 IL6 FCGR2A CD36
34 11.36 TNF TLR2 IL6 CD36
35
Show member pathways
11.27 TNF TLR6 TLR2 IL6 FCGR2A F2
36 11.02 TNF IL6
37 10.97 TNF IL6 CRP
38 10.85 TNF CD36

GO Terms for Infective Endocarditis

Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 TNF TLR6 TLR2 ITGB3 GP1BA CD36
2 extracellular space GO:0005615 9.61 TNF SERPINE1 LBP IL6 GP1BA F2
3 membrane raft GO:0045121 9.46 TNF TLR6 TLR2 CD36
4 platelet alpha granule membrane GO:0031092 9.26 ITGB3 CD36
5 cell surface GO:0009986 9.17 TNF TLR2 LBP ITGB3 GP1BA CD36

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.99 TNF LBP IL6 CD36
2 blood coagulation GO:0007596 9.96 ITGB3 GP1BA F2 CD36
3 cellular response to lipopolysaccharide GO:0071222 9.93 TNF SERPINE1 LBP IL6 CD36
4 platelet degranulation GO:0002576 9.91 SERPINE1 ITGB3 CD36 APOH
5 platelet activation GO:0030168 9.9 ITGB3 IL6 GP1BA F2
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNF TLR6 TLR2 IL6 CD36
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 ITGB3 IL6 CD36
8 defense response to Gram-negative bacterium GO:0050829 9.86 SERPINE1 LBP IL6
9 positive regulation of inflammatory response GO:0050729 9.86 TNF TLR2 SERPINE1
10 positive regulation of tumor necrosis factor production GO:0032760 9.83 TLR2 LBP CD36
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF TLR6 CD36
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 LBP
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.8 TLR6 TLR2 CD36
14 toll-like receptor signaling pathway GO:0002224 9.78 TLR6 TLR2 LBP CD36
15 fibrinolysis GO:0042730 9.77 SERPINE1 GP1BA F2
16 microglial cell activation GO:0001774 9.76 TNF TLR6 TLR2
17 acute-phase response GO:0006953 9.76 LBP IL6 F2 CRP
18 blood coagulation, intrinsic pathway GO:0007597 9.75 GP1BA F2 APOH
19 negative regulation of growth of symbiont in host GO:0044130 9.74 TNF LBP CD36
20 positive regulation of interleukin-8 production GO:0032757 9.73 TNF TLR2 SERPINE1 LBP
21 regulation of blood coagulation GO:0030193 9.72 GP1BA F2 APOH
22 response to fatty acid GO:0070542 9.71 TLR2 CD36
23 apoptotic cell clearance GO:0043277 9.71 ITGB3 CD36
24 positive regulation of macrophage activation GO:0043032 9.71 TLR6 LBP
25 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6
26 negative regulation of blood coagulation GO:0030195 9.71 SERPINE1 APOH
27 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.7 TLR6 CD36
28 regulation of cytokine secretion GO:0050707 9.7 TLR6 TLR2
29 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.7 ITGB3 CRP
30 cell activation GO:0001775 9.7 TLR6 TLR2
31 negative regulation of fibrinolysis GO:0051918 9.7 SERPINE1 F2 APOH
32 cellular response to lipoteichoic acid GO:0071223 9.69 TLR2 LBP CD36
33 opsonization GO:0008228 9.68 LBP CRP
34 interleukin-1 beta secretion GO:0050702 9.68 TLR6 CD36
35 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.68 TLR6 CD36
36 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.67 TLR6 CD36
37 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL6
38 triglyceride transport GO:0034197 9.66 CD36 APOH
39 positive regulation of interleukin-6 production GO:0032755 9.65 TNF TLR2 LBP IL6 CD36
40 nitric oxide metabolic process GO:0046209 9.64 TLR6 TLR2
41 cellular response to bacterial lipopeptide GO:0071221 9.64 TLR2 CD36
42 response to bacterial lipoprotein GO:0032493 9.62 TLR6 TLR2
43 positive regulation of blood microparticle formation GO:2000334 9.62 TNF CD36
44 positive regulation of chemokine production GO:0032722 9.62 TNF TLR2 LBP IL6
45 detection of diacyl bacterial lipopeptide GO:0042496 9.61 TLR6 TLR2
46 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.58 TLR6 TLR2 CD36
47 cellular response to diacyl bacterial lipopeptide GO:0071726 9.54 TLR6 TLR2 CD36
48 positive regulation of blood coagulation GO:0030194 9.46 SERPINE1 F2 CD36 APOH
49 negative regulation of lipid storage GO:0010888 9.26 TNF ITGB3 IL6 CRP
50 defense response to Gram-positive bacterium GO:0050830 9.1 TNF TLR2 LBP IL6 CRP CD36

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 TNF TLR6 TLR2 ITGB3 CRP APOH
2 signaling receptor binding GO:0005102 9.76 TLR6 SERPINE1 LBP F2
3 protease binding GO:0002020 9.58 TNF SERPINE1 ITGB3
4 low-density lipoprotein particle binding GO:0030169 9.43 CRP CD36
5 Toll-like receptor binding GO:0035325 9.32 TLR2 CD36
6 thrombospondin receptor activity GO:0070053 9.26 F2 CD36
7 lipopolysaccharide binding GO:0001530 9.13 TLR2 LBP F2
8 lipopeptide binding GO:0071723 8.8 TLR6 TLR2 LBP
9 protein binding GO:0005515 10 TNNI3 TNF TLR6 TLR2 SERPINE1 LBP

Sources for Infective Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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