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MCID: INF034
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Infective Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Nephrological diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Infective Endocarditis

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MalaCards integrated aliases for Infective Endocarditis:

Name: Infective Endocarditis 11 19 58 75 14 71
Bacterial Endocarditis 58 75 16 71
Endocarditis, Infective 19 75
Infectious Endocarditis 58
Endocarditis Infective 53

Characteristics:


Prevelance:

1-9/100000 (France, Denmark, Europe) 58

Age Of Onset:

All ages 58

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Cardiovascular diseases Skin diseases Nephrological diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 11 DOID:0060000
ICD10 via Orphanet 32 I33.0
Orphanet 58 ORPHA570762
UMLS 71 C0014121 C1541923
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Summaries for Infective Endocarditis

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GARD: 19 "Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called ""endocarditis,"" although it is important to distinguish it from non-Infective endocarditis. IE is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damage the heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart."

MalaCards based summary: Infective Endocarditis, also known as bacterial endocarditis, is related to endocarditis and nonbacterial thrombotic endocarditis, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CNMD (Chondromodulin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Complement cascade. The drugs Imipenem and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and skin, and related phenotypes are homeostasis/metabolism and cardiovascular system

Orphanet: 58 A rare bacterial infectious disease characterized by infection of a native or prosthetic heart valve, the endocardial surface, or an indwelling cardiac device. Main causative agents are Gram-positive bacteria, most commonly Staphylococcus and Streptococcus species. Signs and symptoms include high fever or prolonged subfebrile state, excessive sweating, malaise, asthenia, arthralgia, myalgia, weight loss, headache, nausea, dyspnea, cough, heart murmurs, and petechiae of the skin. The most common complications are embolism in different organs and ischemic stroke, sepsis, heart failure, and renal failure.

Disease Ontology: 11 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia 75 Bacterial endocarditis: Infective endocarditis is an infection of the inner surface of the heart, usually the valves. Signs and... more...

Endocarditis, infective: Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...
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Related Diseases for Infective Endocarditis

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Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1266)
# Related Disease Score Top Affiliating Genes
1 endocarditis 33.1 IL6 GP1BA F2 CRP ALB
2 nonbacterial thrombotic endocarditis 32.0 VWF PLG F3 F2 CRP
3 heart septal defect 32.0 F3 F2 CRP
4 mitral valve insufficiency 31.9 F3 F2 CRP ALB
5 subacute bacterial endocarditis 31.9 SRA1 PRTN3 MPO CRP ALB
6 toxic shock syndrome 31.7 IL6 F3 CRP
7 aortic valve insufficiency 31.7 VWF F3 F2 CRP ALB
8 congestive heart failure 31.6 VWF IL6 FN1 ALB
9 tricuspid valve insufficiency 31.4 F3 F2 CRP ALB
10 osteomyelitis 31.4 PPP3CA IL6 CRP
11 acute kidney failure 31.3 PRTN3 IL6 F2 ALB
12 splenic abscess 31.2 F3 F2 CRP ALB
13 heart valve disease 31.1 VWF IL6 F3 F2 CRP CNMD
14 vasculitis 31.0 VWF PRTN3 MPO IL6 CRP
15 immune-complex glomerulonephritis 31.0 PRTN3 CFHR2 ALB
16 patent ductus arteriosus 1 31.0 IL6 F3 F2 CRP ALB
17 pericardial effusion 31.0 IL6 F3 F2 CRP ALB
18 discitis 31.0 TST CRP ALB
19 spondylitis 31.0 IL6 CRP CCR6
20 endophthalmitis 30.9 PLG IL6 CRP ALB
21 splenic infarction 30.9 PRTN3 MPO F3 F2 CRP ALB
22 cholecystitis 30.9 F2 CRP ALB
23 pyelonephritis 30.9 IL6 CRP ALB
24 atrial heart septal defect 30.9 VWF PLG F3 F2 CRP ALB
25 glomerulonephritis 30.9 SERPINH1 PRTN3 MPO IL6 FN1 CRP
26 pulmonary embolism 30.9 VWF MPO GP1BA F3 F2 CRP
27 liver cirrhosis 30.8 IL6 F3 F2 ALB
28 lung abscess 30.8 IL6 CRP ALB
29 libman-sacks endocarditis 30.8 PRTN3 F2 CRP CFHR2
30 bacteriuria 30.8 IL6 CRP ALB
31 mitral valve stenosis 30.8 VWF PLG F3 F2 CRP ALB
32 urinary tract infection 30.8 IL6 F3 F2 CRP CFHR2 CCR6
33 alcohol use disorder 30.8 IL6 F2 CRP CCR6 ALB
34 intracranial embolism 30.8 VWF PLG IL6 F3 F2 CRP
35 hemopericardium 30.7 PLG F3 F2 CRP
36 chronic kidney disease 30.7 VWF IL6 CRP CFHR2 CCR6 ALB
37 cardiac tamponade 30.7 PLG IL6 F3 F2 CRP ALB
38 brucellosis 30.7 MPO IL6 CRP
39 epidural abscess 30.7 F3 F2 CRP ALB
40 purpura 30.7 VWF IL6 GP1BA F3 F2 CRP
41 meningitis 30.7 MPO IL6 FN1 CRP ALB
42 myocarditis 30.6 IL6 FN1 F3 F2 ALB
43 neutrophilia, hereditary 30.6 MPO IL6 CRP
44 septic arthritis 30.6 TST SERPINH1 PPP3CA IL6 FN1 CRP
45 vascular disease 30.6 VWF MPO IL6 GP1BA FN1 F3
46 crescentic glomerulonephritis 30.6 PRTN3 MPO CRP CFHR2 CCR6 ALB
47 rapidly progressive glomerulonephritis 30.6 PRTN3 MPO CRP CFHR2 ALB
48 stroke, ischemic 30.6 VWF PRTN3 PLG IL6 GP1BA F3
49 tenosynovitis 30.6 PRTN3 IL6 CRP
50 cerebrovascular disease 30.6 PLG IL6 F2 CRP CCR6 ALB

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to Infective Endocarditis
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Symptoms & Phenotypes for Infective Endocarditis

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UMLS symptoms related to Infective Endocarditis:


osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ALB CCR6 CNMD CRP F2 F3
2 cardiovascular system MP:0005385 9.93 ALB CCR6 CRP F2 F3 FN1
3 muscle MP:0005369 9.92 ALB F2 F3 FN1 IL6 MPO
4 immune system MP:0005387 9.83 ALB CCR6 CNMD CRP F2 F3
5 hematopoietic system MP:0005397 9.44 CCR6 CNMD F2 F3 FN1 GP1BA
Sources

Drugs & Therapeutics for Infective Endocarditis

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Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
2
Fosfomycin Approved Phase 4 23155-02-4 446987
3
Cefaclor Approved Phase 4 53994-73-3 51039
4
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1, 93107-08-5 2764
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
6
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8
Ethinylestradiol Approved Phase 4 57-63-6 5991
9
Polyestradiol phosphate Approved Phase 4 28014-46-2
10
Fusidic acid Approved, Investigational Phase 4 6990-06-3 3000226
11
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
12
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
13
Ofloxacin Approved Phase 4 82419-36-1 4583
14
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
15
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
16
Tedizolid Approved, Investigational Phase 4 856866-72-3
17
Moxifloxacin Approved, Investigational Phase 4 186826-86-8, 354812-41-2, 151096-09-2 152946
18
Sulfamethoxazole Approved Phase 4 723-46-6 5329
19
Rifampicin Approved Phase 4 13292-46-1 135512673 5381226 135900090
20
Clindamycin Approved, Vet_approved Phase 4 18323-44-9, 24729-96-2 29029
21
Dicloxacillin Approved, Investigational, Vet_approved Phase 4 3116-76-5 18381
22
Meticillin Approved, Investigational Phase 4 61-32-5 6087
23
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
24
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
25 Anesthetics Phase 4
26 Antibiotics, Antitubercular Phase 4
27 Antitubercular Agents Phase 4
28 Folic Acid Antagonists Phase 4
29 Folate Phase 4
30 Vitamin B9 Phase 4
31 Estradiol 3-benzoate Phase 4
32 Estradiol 17 beta-cypionate Phase 4
33 Antiprotozoal Agents Phase 4
34 Antiparasitic Agents Phase 4
35 Vitamin B Complex Phase 4
36 Antimalarials Phase 4
37 Contraceptives, Oral, Combined Phase 4
38 Contraceptives, Oral Phase 4
39 Contraceptive Agents Phase 4
40 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
41 Norgestimate, ethinyl estradiol drug combination Phase 4
42 Cytochrome P-450 Enzyme Inhibitors Phase 4
43 Oxazolidinones Phase 4
44
Clindamycin phosphate Phase 4 32603
45 Clindamycin palmitate Phase 4
46 Anti-Bacterial Agents Phase 4
47 Anti-Infective Agents Phase 4
48 Gentamicins Phase 4
49
Ceftobiprole medocaril Approved, Experimental, Investigational Phase 3 376653-43-9 139292184
50
Ceftobiprole Approved, Investigational Phase 3 209467-52-7 139595999

Interventional clinical trials:

(show top 50) (show all 90)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
2 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
3 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
4 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
5 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
6 Short-course Antibiotic Regimen Compared to Conventional Antibiotic Treatment for Gram-positive Cocci Infective Endocarditis: Randomized Clinical Trial Recruiting NCT04222257 Phase 4 Antibiotics
7 Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis Not yet recruiting NCT05398679 Phase 4 Cefaclor;Ciprofloxacin Tablets;Ciprofloxacin Injection;Clindamycin Oral Capsule;Clindamycin Injection;Dicloxacillin Oral Capsule;Dicloxacillin;Fusidic Acid Only Product in Oral Dose Form;Fusidic Acid Only Product in Parenteral Dose Form;Levofloxacin Oral Tablet;Levofloxacin Injection;Linezolid Oral Tablet;Linezolid Injectable Product;Moxifloxacin tablet;Moxifloxacin Injectable Product;Rifampicin Only Product in Oral Dose Form;Rifampicin Only Product in Parenteral Dose Form;Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim];Sulfamethoxazole / Trimethoprim Injectable Product;Tedizolid Oral Tablet;Tedizolid Injection;Amoxicillin Capsules;Amoxicillin;Cefaclor Capsules
8 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
9 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
10 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
11 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Completed NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
12 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
13 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
14 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Terminated NCT04160468 Phase 3 Exebacase;Placebo
15 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
16 Phase II Clinical Trial to Evaluate an Antibiotic Regimen Pharmacokinetic Applicable to Outpatient Parenteral Antimicrobial Therapy in Enterococcus Faecalis Infective Endocarditis Unknown status NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
17 Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis" Unknown status NCT04691440 Phase 2 Hyperbaric oxygen
18 Early Feasibility Study of Somatostatin Receptors PET Imaging (68Ga-DOTATOC PET/CT) for the Diagnosis of Infective Endocarditis Not yet recruiting NCT05183555 Phase 2 68Ga-DOTATOC PET/CT
19 Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis Not yet recruiting NCT05446376 Phase 2 68Ga-citrate PET/CT
20 Phase 2, Open-Label, Randomized, Multicenter Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Documented Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
21 A Phase 2 Multicenter, Randomized, Double-blinded, Study to Describe the Safety, Efficacy, and Pharmacokinetics of Daptomycin 10 mg/kg/Day and Vancomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
22 An Open-Label, Multiple-Ascending Dose, Multicenter Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LSVT-1701 as an Add-on to Standard of Care Antibiotics for the Treatment of Complicated Methicillin-Sensitive and -Resistant Staphylococcus Aureus Bacteremia Including Left- and Right-sided Infective Endocarditis Withdrawn NCT05329168 Phase 2 Tonabacase (LSVT-1701)
23 Treatment of Infective Endocarditis by Vancomycin and Gentamycin in Assiut University Children Hospital Unknown status NCT03688659 Vancomycin and gentamycin
24 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Unknown status NCT02698930 dexmedetomidine;Normal saline
25 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
26 Beta-lactam Pharmacokinetic Profiles in Patients With Infective Endocarditis Unknown status NCT02033421
27 NExt-Generation Sequencing and Cell Culture-based Characterization of S. Aureus in Infective Endocarditis Unknown status NCT04257292
28 The Use of Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
29 Cytokine REmoval in CRitically Ill pAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE) - an Investigator-initiated Prospective Randomized Controlled Clinical Trial Comparing Two Established Clinical Protocols Unknown status NCT03892174
30 Molecular Imaging in Infective Endocarditis Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR) and Computed Tomography (PET/CT) Unknown status NCT03626571
31 Study of Autoantibodies in Infective Endocarditis Unknown status NCT00562653
32 Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis - A Multicenter Partially Randomized Preference Trial (EARLY Study) Unknown status NCT03411499
33 Detection of the Most Common Micro Organism of Infective Endocarditis in Assiut University Hospital Unknown status NCT03487653
34 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
35 Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections Unknown status NCT04178915
36 Etiology of Endocarditis in Negative Blood Cultures Unknown status NCT02816307
37 Endocarditis Registry of the University Hospital of Cologne (ER-UHC) Unknown status NCT02388893
38 Gender Study on Predisposition to Infectious Endocarditis Unknown status NCT03979261
39 Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiovascular Implantable Electronic Device Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
40 Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis Unknown status NCT02252900
41 Impact of Setting up a Multidisciplinary Consensus Meeting in the Prognosis and Management of Infectious Endocarditis at Strasbourg University Hospital. Unknown status NCT03429153
42 INfecTive ENdocarditis After Transcatheter Aortic Valve Replacement (TAVR) a National SwEdish Study (INTENSE) Completed NCT03768180
43 Effect of 18-FDG PET/CT Imaging on Clinical Decision Making During the Acute Phase of Infective Endocarditis: a Multicenter Prospective Impact Study Completed NCT02287792
44 Revealing Mechanisms and Investigating Efficacy of Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis - a Multicentric Randomized Controlled Group Sequential Trial Completed NCT03266302
45 Clinical Metagenomics of Infective Endocarditis Completed NCT03199287
46 Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism. Completed NCT00947817
47 Study of the Clinical Presentations, Treatment and Outcomes of Infective Endocarditis Patients in a Tertiary Hospital in East China Completed NCT04977518
48 Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis Using the Imaging Method of Cutaneous Laser Speckle Flowmetry Completed NCT02940340
49 Real-life Use of Cefazolin for the Treatment of Meticillin-susceptible Staphylococcal Infective Endocarditis: Comparison to a Treatment Cohort With Penicillin M Completed NCT05474118
50 Infective Endocarditis in the Elderly: Description of the Geriatric Characteristics and Their Influence on Therapeutic Care and the Morbidity and Mortality at 3 Months (ELDERL-IE) Completed NCT02910856

Search NIH Clinical Center for Infective Endocarditis

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Genetic Tests for Infective Endocarditis

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Anatomical Context for Infective Endocarditis

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Organs/tissues related to Infective Endocarditis:

MalaCards : Heart, Kidney, Skin, Endothelial, Whole Blood, Brain, Liver
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Publications for Infective Endocarditis

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Articles related to Infective Endocarditis:

(show top 50) (show all 19342)
# Title Authors PMID Year
1
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]. 53 62
17339740 2007
2
Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. 53 62
16980969 2006
3
Metabolism of glycoprotein-derived sialic acid and N-acetylglucosamine by Streptococcus oralis. 53 62
8704962 1996
4
Association of Intravenous Drug Use and Length of Stay Following Infective Endocarditis. 62
36332302 2023
5
Cardiac Magnetic Resonance Imaging for the Diagnosis of Infective Endocarditis in the COVID-19 Era. 62
36126764 2023
6
Infective endocarditis caused by Chaetomium globosum. 62
35970486 2023
7
Oral microbiomes of patients with infective endocarditis (IE): a comparative pilot study of IE patients, patients at risk for IE and healthy controls. 62
36407280 2023
8
A case of mediastinal abscess and infected aortic aneurysm caused by dissemination of Mycobacterium abscessus subsp. massiliense pulmonary disease. 62
36162647 2023
9
Demographic and Regional Trends of Infective Endocarditis-Related Mortality in the United States, 1999 to 2019. 62
36100097 2023
10
Neurocritical Care Aspects of Ischemic Stroke Management. 62
36333037 2023
11
Lipomatous hypertrophy of the interatrial septum: A potential pitfall resolved on comparing previous PET/CT. 62
36340220 2023
12
Nanotechnology in interventional cardiology: A state-of-the-art review. 62
36425567 2022
13
Valve-in-valve transcatheter aortic valve replacement versus redo aortic valve replacement: which procedure for which patient? 62
36433699 2022
14
Pilus PilA of the naturally competent HACEK group pathogen Aggregatibacter actinomycetemcomitans stimulates human leukocytes and interacts with both DNA and proinflammatory cytokines. 62
36374775 2022
15
3-Dimensional Images of Mitral Annulus Perforation: An Alien's Mouth. 62
36438889 2022
16
Aortic Prosthetic Valve Endocarditis: Analysis of The Society of Thoracic Surgeons Database. 62
34875263 2022
17
Endocarditis-associated rapidly progressive glomerulonephritis mimicking vasculitis: a diagnostic and treatment challenge. 62
35243934 2022
18
Valve-in-Valve Using Perceval Prostheses for Prosthetic Valve Endocarditis. 62
35257677 2022
19
Tricuspid Valve Endocarditis in Four Patients with Unrepaired Restrictive Perimembranous Ventricular Septal Defects. 62
35657420 2022
20
Surgical explantation of failed transcatheter heart valves: indications and results. 62
35802181 2022
21
IgA Vasculitis With Concurrent ANCA-Positivity in the Setting of Bacterial Endocarditis. 62
36413453 2022
22
Streptococcus pasteurianus-induced valvular endocarditis and sepsis in a puerperal emperor tamarin (Saguinus imperator). 62
35451506 2022
23
The Impact of Frailty Syndrome on Endogenous Endophthalmitis Development and Outcomes: A Population-Level Analysis. 62
35843372 2022
24
Tricuspid Aortic Valve Reconstruction with Autologous Pericardium (Ozaki Technique) in Bicuspid Aortic Valve Infective Endocarditis. 62
36459473 2022
25
Successful treatment of canine infective endocarditis caused by Bacillus amyloliquefaciens. 62
35068361 2022
26
Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release. 62
36453281 2022
27
Predicting bacteremia caused by Streptococcus anginosus group: A new scoring method. 62
36049615 2022
28
Streptococcus cristatus, an infrequent cause of bacteremia and infective endocarditis. Case report and literature review. 62
36458725 2022
29
Harms and Contributors of Leaving Against Medical Advice in Patients With Infective Endocarditis. 62
35797474 2022
30
Outcomes After Tricuspid Valve Operations in Patients With Drug-Use Infective Endocarditis. 62
36280471 2022
31
Advanced Cardiovascular Imaging for the Diagnosis of Mycobacterium chimaera Prosthetic Valve Infective Endocarditis After Open-heart Surgery: A Contemporary Systematic Review. 62
36100093 2022
32
Antibiotic Prophylaxis for Infective Endocarditis: A Survey of Practice Among Pediatric Cardiology Providers. 62
35854631 2022
33
Infective Endocarditis Revealed after Resolution of COVID-19 Infection. 62
36104198 2022
34
Vegetation Size, Multiplicity, and Position in Patients With Infective Endocarditis. 62
34929143 2022
35
In adults, risk for infective endocarditis varied for invasive dental procedures and by antibiotic prophylaxis. 62
36469928 2022
36
Native valve infective endocarditis: a rare complication of rat bite fever caused by Streptobacillus moniliformis. 62
36379219 2022
37
Streptococcus mutans PrsA mediates AtlA secretion contributing to extracellular DNA release and biofilm formation in the pathogenesis of infective endocarditis. 62
35876630 2022
38
Left-Sided Infective Endocarditis: Time to Personalize Care Management. 62
35798122 2022
39
Surgical versus medical treatment for infective endocarditis in patients on dialysis: a systematic review and meta-analysis. 62
35450507 2022
40
Early Mortality Predictors in Ä°nfective Endocarditis Patients: A Single-Center Surgical Experience. 62
36259995 2022
41
Long-term outcomes of mechanical versus biological valve prosthesis in native mitral valve infective endocarditis. 62
35652503 2022
42
[Infective endocarditis misdiagnosed as IgA vasculitis]. 62
36456519 2022
43
Strengths and limitations of patient registries in infective endocarditis. 62
36464215 2022
44
Infective endocarditis in paediatric patients from Andalusia (Spain), 2008-2020. 62
36464618 2022
45
Native mitral valve infective endocarditis caused by Actinobacillus equuli. 62
36435191 2022
46
Prophylaxis of Infective Endocarditis: A Cross Sectional Survey among Physician Members of the Portuguese Society of Cardiology. 62
35678339 2022
47
Focal myocardial effects in infective endocarditis. 62
36074334 2022
48
Focal myocardial effects in infective endocarditis. 62
36074335 2022
49
Increasing clinical impact and microbiological difficulties in diagnosing coagulase-negative staphylococci in infective endocarditis - a review starting from a series of cases. 62
36073863 2022
50
A novel approach for debulking mitral valve infective endocarditis; why swim against the current? 62
35998783 2022
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Variations for Infective Endocarditis

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Expression for Infective Endocarditis

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Search GEO for disease gene expression data for Infective Endocarditis.
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Pathways for Infective Endocarditis

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Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.92 VWF PRTN3 PLG GP1BA FN1 F3
2
Complement cascade 66
Show member pathways
 12.39 PLG F2 CRP CFHR2 ALB
3
Immune response IL-23 signaling pathway 22
Show member pathways
 12.33 PLG MPO IL6 FN1 F2
4
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
Show member pathways
 11.92 PLG IL6 FN1 F2 ALB
5
CCL18 signaling pathway 74
11.65 IL6 FN1 CCR6
6
Integrin signaling 66
Show member pathways
 11.6 F2 FN1 GP1BA VWF
7
C-MYB transcription factor network 61
11.56 PRTN3 PPP3CA MPO
8
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 66
Show member pathways
 11.56 VWF PRTN3 PLG GP1BA F3 F2
9
Syndecan-4-mediated signaling events 61
11.04 PLG FN1 F2
10
Overview of nanoparticle effects 74
10.41 IL6 FN1 CRP
11
COVID-19, thrombosis and anticoagulation 74
10.3 PLG F2
Sources

GO Terms for Infective Endocarditis

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Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.32 ALB CFHR2 CNMD CRP F2 F3
2 blood microparticle GO:0072562 9.92 PLG FN1 F2 ALB
3 collagen-containing extracellular matrix GO:0062023 9.8 F2 F3 FN1 PLG PRTN3 SERPINH1
4 extracellular space GO:0005615 9.77 VWF TST SERPINH1 PRTN3 PLG MPO
5 platelet alpha granule lumen GO:0031093 9.76 VWF PLG FN1 ALB

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.86 VWF IL6 GP1BA F2
2 fibrinolysis GO:0042730 9.8 PLG GP1BA F2
3 acute-phase response GO:0006953 9.76 CRP F2 FN1 IL6
4 biological process involved in interaction with symbiont GO:0051702 9.67 PLG FN1
5 blood coagulation GO:0007596 9.65 VWF PLG GP1BA F3 F2
6 hemostasis GO:0007599 9.1 VWF PLG GP1BA F3 F2

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.23 VWF PLG FN1 ALB
Sources

Sources for Infective Endocarditis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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