MCID: INF133
MIFTS: 28

Inferior Vena Cava Interruption

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Inferior Vena Cava Interruption

MalaCards integrated aliases for Inferior Vena Cava Interruption:

Name: Inferior Vena Cava Interruption 59
Inferior Caval Vein Interruption 59
Ivc Interruption 59

Classifications:



External Ids:

Orphanet 59 ORPHA99123
ICD10 via Orphanet 34 Q26.8

Summaries for Inferior Vena Cava Interruption

MalaCards based summary : Inferior Vena Cava Interruption, also known as inferior caval vein interruption, is related to pulmonary embolism and thrombosis. An important gene associated with Inferior Vena Cava Interruption is F5 (Coagulation Factor V), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drug Kava has been mentioned in the context of this disorder. Affiliated tissues include lung, liver and heart, and related phenotype is integument.

Related Diseases for Inferior Vena Cava Interruption

Diseases related to Inferior Vena Cava Interruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 pulmonary embolism 29.1 F5 MTHFR SERPINE1
2 thrombosis 28.7 F5 MTHFR SERPINE1
3 dextrocardia 10.1
4 sticky platelet syndrome 10.1 F5 SERPINE1
5 meningococcemia 10.1 F5 SERPINE1
6 factor xiii deficiency 10.0 F5 SERPINE1
7 post-thrombotic syndrome 10.0 F5 SERPINE1
8 quebec platelet disorder 10.0 F5 SERPINE1
9 legg-calve-perthes disease 10.0 F5 SERPINE1
10 heart disease 10.0
11 double inferior vena cava 10.0
12 neonatal stroke 9.9 MTHFR SERPINE1
13 disseminated intravascular coagulation 9.8 F5 SERPINE1
14 buerger disease 9.8 MTHFR SERPINE1
15 lemierre's syndrome 9.8 MTHFR SERPINE1
16 hepatic vascular disease 9.8 MTHFR SERPINE1
17 spinal cord infarction 9.7 F5 MTHFR
18 sudden sensorineural hearing loss 9.7 F5 MTHFR
19 porencephaly 9.7 F5 MTHFR
20 intracranial thrombosis 9.7 F5 MTHFR
21 retinal vascular occlusion 9.7 F5 MTHFR
22 antithrombin iii deficiency 9.7 F5 MTHFR
23 central retinal vein occlusion 9.7 F5 MTHFR
24 patent foramen ovale 9.7 F5 MTHFR
25 arteritic anterior ischemic optic neuropathy 9.7 F5 MTHFR
26 protein s deficiency 9.6 F5 MTHFR
27 vein disease 9.6 F5 MTHFR
28 osteonecrosis 9.6 MTHFR SERPINE1
29 placental abruption 9.6 F5 MTHFR
30 thrombasthenia 9.6 F5 MTHFR
31 protein c deficiency 9.6 F5 MTHFR
32 ischemic optic neuropathy 9.6 F5 MTHFR
33 schizencephaly 9.6 F5 MTHFR
34 blood coagulation disease 9.6 F5 MTHFR
35 nonarteritic anterior ischemic optic neuropathy 9.6 F5 MTHFR
36 placenta disease 9.5 F5 MTHFR
37 budd-chiari syndrome 9.5 F5 MTHFR
38 homocysteinemia 9.4 F5 MTHFR
39 varicose veins 9.4 F5 MTHFR
40 antiphospholipid syndrome 9.4 F5 MTHFR
41 cerebral palsy 9.3 F5 MTHFR
42 eclampsia 9.2 F5 MTHFR
43 amaurosis fugax 9.2 F5 MTHFR SERPINE1
44 livedoid vasculopathy 9.2 F5 MTHFR SERPINE1
45 catastrophic antiphospholipid syndrome 9.2 F5 MTHFR SERPINE1
46 cryptogenic cirrhosis 9.2 F5 MTHFR SERPINE1
47 retinal artery occlusion 9.2 F5 MTHFR SERPINE1
48 thrombophlebitis 9.2 F5 MTHFR SERPINE1
49 portal vein thrombosis 9.2 F5 MTHFR SERPINE1
50 intracranial hypertension 9.2 F5 MTHFR SERPINE1

Graphical network of the top 20 diseases related to Inferior Vena Cava Interruption:



Diseases related to Inferior Vena Cava Interruption

Symptoms & Phenotypes for Inferior Vena Cava Interruption

MGI Mouse Phenotypes related to Inferior Vena Cava Interruption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.8 F5 MTHFR SERPINE1

Drugs & Therapeutics for Inferior Vena Cava Interruption

Drugs for Inferior Vena Cava Interruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Kava Approved, Investigational, Nutraceutical 9000-38-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data Completed NCT01929967

Search NIH Clinical Center for Inferior Vena Cava Interruption

Genetic Tests for Inferior Vena Cava Interruption

Anatomical Context for Inferior Vena Cava Interruption

MalaCards organs/tissues related to Inferior Vena Cava Interruption:

41
Lung, Liver, Heart

Publications for Inferior Vena Cava Interruption

Articles related to Inferior Vena Cava Interruption:

(show all 23)
# Title Authors Year
1
Management of scar-related atrial flutter in a patient with dextrocardia, inferior vena cava interruption, and azygos continuation. ( 29424736 )
2018
2
Catheter ablation of typical atrial flutter with the superior approach in a patient with inferior vena cava interruption. ( 29152281 )
2017
3
Catheter ablation of atrial arrhythmias in a patient with surgically corrected congenital heart disease and inferior vena cava interruption. ( 26136634 )
2015
4
Inferior vena cava interruption in a liver transplantation deceased donor. ( 23230844 )
2013
5
Transapical closure of paraprosthetic mitral leak in a patient with inferior vena cava interruption and azygos continuation. ( 24048023 )
2013
6
Deep vein thrombosis, inferior vena cava interruption and multiple thrombophilic gene mutations. ( 21642818 )
2011
7
Atrial flutter ablation through the azygous continuation in a patient with inferior vena cava interruption. ( 21030393 )
2011
8
Infrahepatic caudal/inferior vena cava interruption with azygos/hemiazygos continuation. Vascular anomaly in swine. ( 22933907 )
2010
9
Pulmonary embolism associated with inferior vena cava interruption: multidetector computed tomography findings. ( 20498625 )
2010
10
Radiofrequency ablation of atrioventricular nodal tachycardia in a patient with dextrocardia, inferior vena cava interruption, and azygos continuation. ( 18031517 )
2008
11
Catheter ablation of left free wall accessory pathway in a patient with inferior vena cava interruption. ( 12674185 )
2002
12
Inferior vena cava interruption: how and when? ( 10774449 )
2000
13
Inferior vena cava interruption with renal vein collar continuation: CT and MRI appearance. ( 1773417 )
1991
14
The Vena Tech filter: evaluation of a new inferior vena cava interruption device. ( 1939334 )
1991
15
Transvenous devices for inferior vena cava interruption. ( 2585660 )
1989
16
Inferior vena cava interruption with the Hunter-Sessions balloon: eighteen years' experience in 191 cases. ( 2795770 )
1989
17
Recurrent, fatal pulmonary embolism despite inferior vena cava interruption with the Greenfield filter. ( 3577368 )
1987
18
Inferior vena cava interruption. ( 3874355 )
1985
19
Inferior vena cava interruption in the management of pulmonary embolism. ( 7140404 )
1982
20
Requirements for a method of transvenous inferior vena cava interruption. ( 7436725 )
1980
21
Diagnosis of pulmonary embolism: correlation of value of perfusion lung scan and pulmonary arteriography in selecting patients for inferior vena cava interruption. ( 637417 )
1978
22
Inferior vena cava interruption: a new indication? ( 1164184 )
1975
23
Fatal complications following inferior vena cava interruption. ( 5159420 )
1971

Variations for Inferior Vena Cava Interruption

Expression for Inferior Vena Cava Interruption

Search GEO for disease gene expression data for Inferior Vena Cava Interruption.

Pathways for Inferior Vena Cava Interruption

GO Terms for Inferior Vena Cava Interruption

Cellular components related to Inferior Vena Cava Interruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 F5 SERPINE1

Biological processes related to Inferior Vena Cava Interruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.96 F5 SERPINE1
2 blood circulation GO:0008015 8.62 F5 MTHFR

Sources for Inferior Vena Cava Interruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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