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MCID: INF032
MIFTS: 58

Infertility

Categories: Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Infertility

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MalaCards integrated aliases for Infertility:

Name: Infertility 12 29 55 6 43 3 44 15 63 73

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5223
MeSH 44 D007246
NCIt 50 C3836
SNOMED-CT 68 15296000 8619003
UMLS 73 C0021359
Sources

Summaries for Infertility

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MedlinePlus : 43 Infertility means not being able to become pregnant after a year of trying. If a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. Infertility is fairly common. After one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. About a third of the time, infertility can be traced to the woman. In another third of cases, it is because of the man. The rest of the time, it is because of both partners or no cause can be found. There are treatments that are specifically for men or for women. Some involve both partners. Drugs, assisted reproductive technology, and surgery are common treatments. Happily, many couples treated for infertility go on to have babies. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Infertility is related to male infertility and catsper-related male infertility, and has symptoms including pelvic pain An important gene associated with Infertility is NPHP4 (Nephrocystin 4), and among its related pathways/superpathways are G alpha (s) signalling events and Reproduction. The drugs Metformin and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and pituitary, and related phenotypes are cellular and endocrine/exocrine gland

CDC : 3 Pregnancy is the result of a process that has many steps.

PubMed Health : 63 About infertility: Not being able to have children is often a source of great emotional turmoil. Many men and women take it for granted that they will be able to have children. If they are not able to conceive, many couples start looking for medical help at some point. A number of different treatments are available, depending on the possible causes of infertility.Problems conceiving a child are defined by medical experts as “infertility” if a couple has had regular unprotected sex for one year without the woman becoming pregnant.

Wikipedia : 76 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

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Related Diseases for Infertility

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Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 489)
# Related Disease Score Top Affiliating Genes
1 male infertility 34.2 CATSPER1 CATSPER2 DAZ1 DAZ4 DAZL DNAH1
2 catsper-related male infertility 33.7 CATSPER1 CATSPER2
3 non-syndromic male infertility due to sperm motility disorder 33.7 CATSPER1 DNAH1
4 female infertility due to zona pellucida defect 33.6 ZP1 ZP3
5 spermatogenic failure 5 33.5 AURKC DPY19L2
6 oocyte maturation defect 1 33.2 CYP19A1 ZP1
7 azoospermia 32.6 DAZ1 DAZ4 DAZL FSHB
8 spermatogenic failure, x-linked, 1 32.5 DAZ1 DAZ4 DAZL
9 spermatogenic failure, y-linked, 2 32.5 DAZ1 DAZ4
10 oligoasthenoteratozoospermia 32.4 CATSPER1 DAZL
11 endometriosis 32.4 CYP19A1 H19 NR5A1
12 cryptorchidism, unilateral or bilateral 32.3 CYP19A1 DAZ1 NR5A1
13 anovulation 32.1 CYP19A1 FSHB FSHR
14 premature ovarian failure 1 32.1 CYP19A1 DAZL FSHR INHA NR5A1 ZP3
15 hypogonadotropic hypogonadism 23 without anosmia 31.5 FSHR LHB
16 46,xx sex reversal 1 31.5 FSHR NR5A1
17 hypogonadism 30.8 FSHB LHB LHCGR
18 ovarian disease 30.4 CYP19A1 FSHR LHCGR NR5A1 ZP1 ZP3
19 amenorrhea 30.3 FSHB FSHR LHB LHCGR NR5A1
20 ovarian hyperstimulation syndrome 30.2 CYP19A1 FSHB FSHR
21 leydig cell tumor 29.8 CYP19A1 LHCGR NR5A1
22 deafness-infertility syndrome 12.5
23 y chromosome infertility 12.4
24 catsper1-related nonsyndromic male infertility 12.2
25 spermatogenic failure 6 12.2
26 male infertility with teratozoospermia due to single gene mutation 12.2
27 female infertility of uterine origin 12.1
28 rare idiopathic male infertility 12.1
29 macrozoospermia 12.1
30 infertility due to extratesticular cause 12.0
31 male infertility with spermatogenesis disorder 12.0
32 male infertility with spermatogenesis disorder due to single gene mutation 12.0
33 female infertility due to oocyte meiotic arrest 12.0
34 spermatogenic failure 1 11.8
35 young syndrome 11.7
36 spermatogenic failure 7 11.7
37 spermatogenic failure 17 11.7
38 spermatogenic failure, x-linked, 2 11.6
39 deafness, autosomal recessive 32, with or without immotile sperm 11.6
40 polycystic ovary syndrome 11.4
41 47, xxy 11.4
42 pelvic inflammatory disease 11.4
43 cystic fibrosis 11.4
44 hypogonadotropic hypogonadism 11.4
45 turner syndrome 11.3
46 hyperprolactinemia 11.3
47 chlamydia 11.3
48 testicular microlithiasis 11.3
49 testicular cancer 11.3
50 primary ciliary dyskinesia 11.3

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility
Sources

Symptoms & Phenotypes for Infertility

About this section

UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 CATSPER1 CATSPER2 CYP19A1 DPY19L2 FSHB FSHR
2 endocrine/exocrine gland MP:0005379 9.65 CYP19A1 DPY19L2 FSHB FSHR INHA LHB
3 reproductive system MP:0005389 9.5 AURKC CATSPER1 CATSPER2 CYP19A1 DNAH1 DPY19L2
Sources

Drugs & Therapeutics for Infertility

About this section

PubMedHealth treatment related to Infertility: 63

There are a number of different treatments for infertility. The exact kind of treatment will mainly be determined by what sort of problem has been diagnosed in the woman or man. For instance, hormones may be used if the woman has an abnormal menstrual cycle. Surgery may be helpful if she has fibroids. Some causes of infertility in men can also be treated with hormones or surgery.If not enough sperm is produced or if the sperm cells don't move enough, the semen can be transferred directly to the woman’s womb. This procedure is called insemination. Artificial insemination is also a treatment option if the couple can't have sex or if the sperm can't pass through the cervical mucus. One alternative is artificial fertilization outside the body (in vitro fertilization, or IVF): In this procedure, eggs are removed from the woman’s ovaries through the vagina using a thin hollow needle, and then combined with sperm from the man. Before the eggs are removed, the woman has hormone therapy to stimulate her ovaries to release several mature eggs during the course of a single menstrual cycle. This hormone therapy can have very strong and unpleasant side effects.The actual fertilization takes place outside of the woman's body in a laboratory. In IVF, sperm cells are added to an egg cell and the fertilization process happens on its own. In intracytoplasmic sperm injection (ICSI), one sperm cell is injected directly into an egg using a fine needle.If the fertilization is a success and the egg cells continue to develop, the doctor implants up to three embryos into the womb. In rare cases more egg cells develop into embryos. The woman can then decide to have them frozen (cryopreserved) or destroyed. This also applies to egg cells in a stage of development called the pronuclear stage, in which the chromosome sets from the sperm and egg cells have not yet fully joined together. Cryopreserved embryos or fertilized egg cells can then be thawed out for use in a later cycle if the first transfer is not successful.

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1301)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
2
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Not Applicable 15307-86-5 3033
3
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
4
Menotropins Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 61489-71-2, 9002-68-0 5360545
5
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-83-0 5994
6
Ganirelix Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 123246-29-7, 124904-93-4 25081094
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2921-57-5
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
10
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 302-25-0
11
Buserelin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57982-77-1
12 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 979-32-8
13
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 28014-46-2
14
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
15
Cetrorelix Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 120287-85-6 16129715 25074887
16
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 112809-51-5 3902
17
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 1177-87-3
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-02-2 5743
19
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53714-56-0 657181 3911
20
Enoxaparin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 9005-49-6 772
21
Clopidogrel Approved Phase 4,Phase 1 113665-84-2, 120202-66-6 60606
22
Ticlopidine Approved Phase 4,Phase 1 55142-85-3 5472
23
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
24
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
25 sodium fluoride Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 7681-49-4
26
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
27
Dimenhydrinate Approved Phase 4,Not Applicable 523-87-5 441281
28
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-56-1 2713 9552079
29
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 501-36-0 445154
30
Simvastatin Approved Phase 4,Phase 3,Not Applicable 79902-63-9 54454
31
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 57-27-2 5288826
32
Levobupivacaine Approved, Investigational Phase 4,Not Applicable 27262-47-1 92253
33
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
34
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
35
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
36
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 100986-85-4 149096
37
Ofloxacin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 82419-36-1 4583
38
Linagliptin Approved Phase 4 668270-12-0 10096344
39
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
40
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-56-6 439302 53477758
41
Misoprostol Approved Phase 4,Phase 3,Phase 2,Not Applicable 59122-46-2 5282381
42
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
43
Neomycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1404-04-2 8378
44
Aluminum hydroxide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 21645-51-2
45
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 84057-95-4 175805 71273
46
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
47
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
48
Succinylcholine Approved Phase 4 306-40-1 5314
49
Povidone-iodine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 25655-41-8
50
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763

Interventional clinical trials:

(show top 50) (show all 4749)
# Name Status NCT ID Phase Drugs
1 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
2 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
3 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
4 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
5 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
6 Intracervical Lidocaine Versus Intramuscular Diclofenac for Pain Relief in HSG in a Tertiary Hospital in Kano Unknown status NCT02918812 Phase 4 Intracervical lidocaine;Intramuscular Diclofenac
7 Predictors of Ovarian Reserve in Infertile Women Unknown status NCT02896023 Phase 4 human menopausal gonadotropin
8 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
9 Metformin in Infertile PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
10 Sildenafil Effect After Ovulation Induction Unknown status NCT02890238 Phase 4 Clomiphene citrate;sildenafil citrate;Placebo
11 Biosimilar Versus Urinary Gonadotropins Unknown status NCT02503605 Phase 4 Biosimilar recombinant FSH;Urinary FSH
12 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
13 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
14 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4 Human Chorionic Gonadotropin (HCG)
15 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
16 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Unknown status NCT02361892 Phase 4 ulipristal acetate
17 Methylprednisolone Addition in IVF Treatment of Infertile Couples Unknown status NCT01220791 Phase 4
18 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
19 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
20 Co Administration of GnRH Agonist and hCG for Final Oocyte Maturation Unknown status NCT02703584 Phase 4 Buseralin;pregnyl
21 the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer . Unknown status NCT02655146 Phase 4 triptorelin 0.1;E2;Progesterone;triptorelin 3.75mg
22 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4 Elonva;Puregon
23 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4 Corifollitropin alfa
24 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
25 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
26 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
27 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
28 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4 HCG;Lupron Trigger;Dual Trigger
29 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
30 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
31 Comparison Between Recombinant Versus Urinary hCG for Ovulation Induction in High Responders Unknown status NCT00415766 Phase 4 rHCG 250ug;uHCG 5000 IU;uHCG 7500 IU
32 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
33 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
34 Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI Unknown status NCT02696330 Phase 4 clopidogrel;enoxaparin;placebo
35 Use of G-CSF Supplemented IVF Medium in Patients Undergoing IVF Unknown status NCT02651285 Phase 4
36 Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ Unknown status NCT02946814 Phase 4 essential oils;essential oils without mouthwash;sterile water
37 Use of Corifolitropin Alfa in Oocyte Donors Unknown status NCT02213627 Phase 4 Corifollitropin alfa;Recombinant FSH;HP-hMG
38 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
39 Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF Unknown status NCT02070198 Phase 4 Long acting FSH and GnRH antagonist;Daily FSH and GnRH antagonist;Triptorelin and recombinant FSH
40 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
41 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
42 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
43 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
44 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Unknown status NCT02357563 Phase 4 ulipristal acetate;Leuprolide acetate
45 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Unknown status NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
46 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Unknown status NCT02165917 Phase 4
47 Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT02766803 Phase 4 Simvastatin and micronized trans-resveratrol
48 The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement Unknown status NCT01312415 Phase 4 Levobupivacaine;Intrathecal morphine
49 Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate Unknown status NCT00480376 Phase 4 ofloxacin;gentamicin
50 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Unknown status NCT02601196 Phase 4 Ulipristal acetate

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: infertility

Sources

Genetic Tests for Infertility

About this section

Genetic tests related to Infertility:

# Genetic test Affiliating Genes
1 Infertility 29
Sources

Anatomical Context for Infertility

About this section

MalaCards organs/tissues related to Infertility:

41
Ovary, Testes, Pituitary, Breast, Uterus, Testis, Bone
Sources

Publications for Infertility

About this section

Articles related to Infertility:

(show top 50) (show all 3393)
# Title Authors Year
1
Before Louise: the history of infertility. ( 30548406 )
2019
2
Possible Mechanisms for The Effects of Calcium Deficiency on Male Infertility. ( 30291684 )
2019
3
Dietary Patterns and The Outcomes of Assisted Reproductive Techniques in Women with Primary Infertility: A Prospective Cohort Study. ( 30291693 )
2019
4
Associations of environmental exposures to methylmercury and selenium with female infertility: A case-control study. ( 30384229 )
2019
5
MTHFR polymorphisms as risk for male infertility in Pakistan and its comparison with socioeconomic status in the world. ( 30468411 )
2019
6
Nationwide survey of urological specialists regarding male infertility: results from a 2015 questionnaire in Japan. ( 29371820 )
2018
7
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. ( 29447380 )
2018
8
Unexplained infertility patients present the mostly impaired levels of progesterone receptors: Prospective observational study. ( 29450939 )
2018
9
How might centralization of male factor infertility care impact patients and residents? ( 29980262 )
2018
10
Changes in practice patterns in male infertility cases in the United States: the trend toward subspecialization. ( 29980267 )
2018
11
Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options. ( 29402199 )
2018
12
Role of Withania somnifera (Ashwagandha) in the management of male infertility. ( 29277366 )
2018
13
Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization. ( 29945770 )
2018
14
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. ( 29449551 )
2018
15
A Dyadic Approach to Infertility Stress, Marital Adjustment, and Depression on Quality of Life in Infertile Couples. ( 29436974 )
2018
16
IL-1E9 C376A Transversion Variant and Risk of Idiopathic Male Infertility in Iranian Men: A Genetic Association Study. ( 29935069 )
2018
17
Mapping Out the under-Recognized Burden of Human Infertility Linked to<i>Schistosoma haematobium</i>Infection. ( 29405110 )
2018
18
Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility. ( 29516876 )
2018
19
Fear and infertility research. ( 29419382 )
2018
20
Point-of-care whole-exome sequencing of idiopathic male infertility. ( 29790874 )
2018
21
Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice. ( 29907856 )
2018
22
Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men. ( 29292525 )
2018
23
Application of induced pluripotent stem cell and embryonic stem cell technology to the study of male infertility. ( 29870061 )
2018
24
Efficacy of GnRH agonist trigger in women having history of follicular-endometrial asynchrony with clomiphene/IUI cycles in unexplained infertility. ( 29955952 )
2018
25
A homozygous FANCM frameshift pathogenic variant causes male infertility. ( 29895858 )
2018
26
The relationship between stress and infertility. ( 29946210 )
2018
27
Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1. ( 29808481 )
2018
28
Molecular mimicry: An explanation for autoimmune diseases and infertility. ( 29935034 )
2018
29
Infertility and recurrent miscarriage in a patient with autoimmune atrophic gastritis. ( 29524079 )
2018
30
Association of the c.-9C&amp;gt;T and c.368A&amp;gt;G transitions in H2BFWT gene with male infertility in an Iranian population. ( 28370107 )
2018
31
Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial. ( 29770466 )
2018
32
Evaluation of the Sysmex UF-1000i system as an alternative for the screening of genital tract inflammation in male infertility patients. ( 29806204 )
2018
33
Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece. ( 29928881 )
2018
34
Male Infertility Diagnosis and Treatment in the Era of InA Vitro Fertilization and Intracytoplasmic Sperm Injection. ( 29406062 )
2018
35
Varicocele management for infertility and pain: A systematic review. ( 29713547 )
2018
36
Influence of all-trans retinoic acid on sperm metabolism and oxidative stress: Its involvement in the physiopathology of varicocele-associated male infertility. ( 29943815 )
2018
37
Comprehensive genetic testing for female and male infertility using next-generation sequencing. ( 29779145 )
2018
38
Can Tangier disease cause male infertility? A case report and an overview on genetic causes of male infertility and hormonal axis involved. ( 29198592 )
2018
39
Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon. ( 29931406 )
2018
40
IL-1RA VNTR and IL-1I+ 4845G&amp;gt;T polymorphisms and risk of idiopathic male infertility in Iranian men: A case-control study and an in silico analysis. ( 29968322 )
2018
41
A case report of successful pregnancy and delivery after peritoneal dialysis in a patient misdiagnosed with primary infertility. ( 29952961 )
2018
42
The effect of low-dose ovarian stimulation with HMG plus progesterone on pregnancy outcome in women with history of recurrent pregnancy loss and secondary infertility: a retrospective cohort study. ( 29433402 )
2018
43
Spirituality, infertility-related stress, and quality of life in Brazilian infertile couples: Analysis using the actor-partner interdependence mediation model. ( 29399819 )
2018
44
Positive and negative adjustment in couples undergoing infertility treatment: The impact of support exchange. ( 29953537 )
2018
45
Amenorrhoea and reversible infertility due to obstructive hydrocephalus: literature review and case report. ( 29430977 )
2018
46
Magnetic resonance hysterosalpingography in diagnostic work-up of female infertility - comparison with conventional hysterosalpingography: a randomised study. ( 29974219 )
2018
47
The association of thyroid function and autoimmunity with ovarian reserve in women seeking infertility care. ( 29943679 )
2018
48
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia. ( 29365104 )
2018
49
Discrepancies between the internet and academic literature regarding vitamin use for male infertility. ( 29928617 )
2018
50
Use of Ultrasound in Male Infertility: Appropriate Selection of Men for Scrotal Ultrasound. ( 29808325 )
2018
Sources

Variations for Infertility

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ClinVar genetic disease variations for Infertility:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NPHP4 NM_015102.4(NPHP4): c.2044C> T (p.Arg682Ter) single nucleotide variant Pathogenic/Likely pathogenic rs137852920 GRCh37 Chromosome 1, 5964776: 5964776
2 NPHP4 NM_015102.4(NPHP4): c.2044C> T (p.Arg682Ter) single nucleotide variant Pathogenic/Likely pathogenic rs137852920 GRCh38 Chromosome 1, 5904716: 5904716
3 MYO6 NM_004999.3(MYO6): c.3176G> C (p.Arg1059Thr) single nucleotide variant Uncertain significance rs202214380 GRCh37 Chromosome 6, 76608128: 76608128
4 MYO6 NM_004999.3(MYO6): c.3176G> C (p.Arg1059Thr) single nucleotide variant Uncertain significance rs202214380 GRCh38 Chromosome 6, 75898411: 75898411

Copy number variations for Infertility from CNVD:

7 (show all 50)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion AZFb infertility
13 266750 Y 1 57772954 Microdeletion AZFc infertility
14 266796 Y 11300000 27200000 Deletion AZF infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZFa infertility
17 266827 Y 11300000 27200000 Microdeletion AZFb infertility
18 266828 Y 11300000 27200000 Microdeletion AZFc infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4LY infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion GOLGAZLY infertility
27 266840 Y 11300000 27200000 Microdeletion NAHR infertility
28 266841 Y 11300000 27200000 Microdeletion NOA infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF infertility
32 266975 Y 174481503 174538309 Microdeletions AZF infertility
33 266976 Y 174481503 174538309 Microdeletions AZFA infertility
34 267088 Y 23407118 25740308 Copy number TTTY17 Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4LY Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation ATPase6 Infertility
49 267527 mtDNA 1 16569 Mutation CYTB Infertility
50 267528 1 183532144 183553084 Mutation ND1 Infertility
Sources

Expression for Infertility

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Search GEO for disease gene expression data for Infertility.
Sources

Pathways for Infertility

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Pathways related to Infertility according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 66
11.83 FSHB FSHR LHB LHCGR
2
Reproduction 66
Show member pathways
 11.44 CATSPER1 CATSPER2 ZP1 ZP3
3
Ovarian steroidogenesis 37
11.24 CYP19A1 FSHB FSHR LHB LHCGR
4
Follicle Stimulating Hormone (FSH) signaling pathway 1
10.93 CYP19A1 FSHB FSHR
5
Transcription_CREM signaling in testis 22
10.77 FSHB FSHR
6
Ovarian Infertility Genes 1
10.67 CYP19A1 DAZL FSHR INHA LHCGR NR5A1
7
Hormone ligand-binding receptors 66
10.37 FSHB FSHR LHB LHCGR
Sources

GO Terms for Infertility

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Cellular components related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motile cilium GO:0031514 9.33 CATSPER1 CATSPER2 DNAH1
2 cilium GO:0005929 9.26 CATSPER1 CATSPER2 DNAH1 NPHP4
3 CatSper complex GO:0036128 8.62 CATSPER1 CATSPER2

Biological processes related to Infertility according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.92 CATSPER1 CATSPER2 DAZ1 DAZ4 DAZL DPY19L2
2 germ cell development GO:0007281 9.61 DAZ1 DAZ4 DAZL
3 oocyte maturation GO:0001556 9.59 DAZL TUBB8
4 peptide hormone processing GO:0016486 9.58 FSHB LHB
5 female gamete generation GO:0007292 9.58 FSHB FSHR
6 female gonad development GO:0008585 9.58 CYP19A1 FSHR NR5A1
7 uterus development GO:0060065 9.57 CYP19A1 FSHR
8 sperm-egg recognition GO:0035036 9.56 CATSPER1 CATSPER2
9 flagellated sperm motility GO:0030317 9.56 CATSPER1 CATSPER2 DNAH1 NPHP4
10 spermatogenesis GO:0007283 9.56 AURKC CATSPER1 CATSPER2 DAZ1 DAZ4 DAZL
11 regulation of osteoclast differentiation GO:0045670 9.55 FSHB FSHR
12 male gonad development GO:0008584 9.55 FSHR INHA LHB LHCGR NR5A1
13 oocyte development GO:0048599 9.54 AURKC ZP3
14 positive regulation of translational initiation GO:0045948 9.54 DAZ1 DAZ4 DAZL
15 positive regulation of adenylate cyclase activity GO:0045762 9.52 FSHR LHCGR
16 ovulation cycle process GO:0022602 9.51 FSHR LHCGR
17 Sertoli cell proliferation GO:0060011 9.49 FSHB FSHR
18 follicle-stimulating hormone signaling pathway GO:0042699 9.48 FSHB FSHR
19 progesterone biosynthetic process GO:0006701 9.46 FSHB LHB
20 hormone-mediated signaling pathway GO:0009755 9.02 FSHB FSHR LHB LHCGR NR5A1
21 multicellular organism development GO:0007275 10.08 CATSPER1 CATSPER2 DAZ1 DAZ4 DAZL DPY19L2

Molecular functions related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.5 FSHB INHA LHB
2 mRNA 3'-UTR binding GO:0003730 9.33 DAZ1 DAZ4 DAZL
3 calcium activated cation channel activity GO:0005227 9.26 CATSPER1 CATSPER2
4 protein-hormone receptor activity GO:0016500 8.96 FSHR LHCGR
5 translation activator activity GO:0008494 8.8 DAZ1 DAZ4 DAZL
Sources

Sources for Infertility

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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