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MCID: INF032
MIFTS: 59

Infertility

Categories: Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Infertility

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MalaCards integrated aliases for Infertility:

Name: Infertility 12 29 55 6 43 3 44 15 63 73

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5223
MeSH 44 D007246
NCIt 50 C3836
UMLS 73 C0021359
Sources

Summaries for Infertility

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MedlinePlus : 43 Infertility means not being able to become pregnant after a year of trying. If a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. Infertility is fairly common. After one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. About a third of the time, infertility can be traced to the woman. In another third of cases, it is because of the man. The rest of the time, it is because of both partners or no cause can be found. There are treatments that are specifically for men or for women. Some involve both partners. Drugs, assisted reproductive technology, and surgery are common treatments. Happily, many couples treated for infertility go on to have babies. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Infertility is related to catsper-related male infertility and non-syndromic male infertility due to sperm motility disorder, and has symptoms including pelvic pain An important gene associated with Infertility is H19 (H19, Imprinted Maternally Expressed Transcript
H19 expression was lower in the infertility group as compared to the control group.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are G alpha (s) signalling events and Fertilization. The drugs Zinc and Flavin Mononucleotide have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and skin, and related phenotypes are cellular and endocrine/exocrine gland

CDC : 3 Pregnancy is the result of a process that has many steps.

PubMed Health : 63 About infertility: Not being able to have children is often a source of great emotional turmoil. Many men and women take it for granted that they will be able to have children. If they are not able to conceive, many couples start looking for medical help at some point. A number of different treatments are available, depending on the possible causes of infertility.Problems conceiving a child are defined by medical experts as “infertility” if a couple has had regular unprotected sex for one year without the woman becoming pregnant.

Wikipedia : 76 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

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Related Diseases for Infertility

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Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 catsper-related male infertility 34.5 CATSPER1 CATSPER2
2 non-syndromic male infertility due to sperm motility disorder 34.4 CATSPER1 DNAH1
3 male infertility 34.4 CATSPER1 CATSPER2 DAZ1 DAZ4 DAZL DNAH1
4 female infertility due to zona pellucida defect 34.3 ZP1 ZP3
5 oocyte maturation defect 1 33.8 CYP19A1 ZP1
6 spermatogenic failure, x-linked, 1 33.2 DAZ1 DAZ4 DAZL
7 azoospermia 33.1 DAZ1 DAZ4 DAZL FSHB
8 cryptorchidism, unilateral or bilateral 32.7 CYP19A1 DAZ1 NR5A1
9 anovulation 32.7 CYP19A1 FSHB FSHR
10 spermatogenic failure, y-linked, 2 32.6 DAZ1 DAZ4
11 endometriosis 32.4 CYP19A1 H19 NR5A1
12 premature ovarian failure 1 32.3 CYP19A1 DAZL FSHR INHA NR5A1 ZP3
13 hypogonadism 32.2 FSHB LHB LHCGR
14 hypogonadotropic hypogonadism 23 without anosmia 32.0 FSHR LHB
15 46,xx sex reversal 1 32.0 FSHR NR5A1
16 ovarian hyperstimulation syndrome 30.7 CYP19A1 FSHB FSHR
17 amenorrhea 30.5 FSHB FSHR LHB LHCGR NR5A1
18 leydig cell tumor 30.5 CYP19A1 LHCGR NR5A1
19 ovarian disease 30.5 CYP19A1 FSHR NR5A1 ZP1 ZP3
20 deafness-infertility syndrome 12.4
21 y chromosome infertility 12.3
22 catsper1-related nonsyndromic male infertility 12.1
23 spermatogenic failure 6 12.1
24 female infertility of uterine origin 12.0
25 rare idiopathic male infertility 11.9
26 macrozoospermia 11.9
27 infertility due to extratesticular cause 11.8
28 spermatogenic failure 5 11.8
29 male infertility with spermatogenesis disorder 11.8
30 male infertility with spermatogenesis disorder due to single gene mutation 11.8
31 male infertility with teratozoospermia due to single gene mutation 11.8
32 female infertility due to oocyte meiotic arrest 11.8
33 spermatogenic failure 1 11.6
34 young syndrome 11.5
35 spermatogenic failure 7 11.5
36 spermatogenic failure, x-linked, 2 11.4
37 spermatogenic failure 17 11.4
38 polycystic ovary syndrome 11.3
39 pelvic inflammatory disease 11.3
40 47, xxy 11.2
41 cystic fibrosis 11.2
42 turner syndrome 11.2
43 hyperprolactinemia 11.1
44 hypogonadotropic hypogonadism 11.1
45 testicular microlithiasis 11.1
46 primary ciliary dyskinesia 11.1
47 testicular cancer 11.1
48 vas deferens, congenital bilateral aplasia of 11.1
49 mumps 11.1
50 chlamydia 11.1

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility
Sources

Symptoms & Phenotypes for Infertility

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UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 FSHR LHB LHCGR NPHP4 NR5A1 ZP3
2 endocrine/exocrine gland MP:0005379 9.65 CYP19A1 DPY19L2 FSHB FSHR INHA LHB
3 reproductive system MP:0005389 9.5 CATSPER2 CYP19A1 DNAH1 DPY19L2 FSHB FSHR
Sources

Drugs & Therapeutics for Infertility

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PubMedHealth treatment related to Infertility: 63

There are a number of different treatments for infertility. The exact kind of treatment will mainly be determined by what sort of problem has been diagnosed in the woman or man. For instance, hormones may be used if the woman has an abnormal menstrual cycle. Surgery may be helpful if she has fibroids. Some causes of infertility in men can also be treated with hormones or surgery.If not enough sperm is produced or if the sperm cells don't move enough, the semen can be transferred directly to the woman’s womb. This procedure is called insemination. Artificial insemination is also a treatment option if the couple can't have sex or if the sperm can't pass through the cervical mucus. One alternative is artificial fertilization outside the body (in vitro fertilization, or IVF): In this procedure, eggs are removed from the woman’s ovaries through the vagina using a thin hollow needle, and then combined with sperm from the man. Before the eggs are removed, the woman has hormone therapy to stimulate her ovaries to release several mature eggs during the course of a single menstrual cycle. This hormone therapy can have very strong and unpleasant side effects.The actual fertilization takes place outside of the woman's body in a laboratory. In IVF, sperm cells are added to an egg cell and the fertilization process happens on its own. In intracytoplasmic sperm injection (ICSI), one sperm cell is injected directly into an egg using a fine needle.If the fertilization is a success and the egg cells continue to develop, the doctor implants up to three embryos into the womb. In rare cases more egg cells develop into embryos. The woman can then decide to have them frozen (cryopreserved) or destroyed. This also applies to egg cells in a stage of development called the pronuclear stage, in which the chromosome sets from the sperm and egg cells have not yet fully joined together. Cryopreserved embryos or fertilized egg cells can then be thawed out for use in a later cycle if the first transfer is not successful.

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1225)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-66-6 23994
2
Flavin Mononucleotide Approved, Investigational Phase 4,Phase 2,Phase 3 146-17-8 643976
3
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
4
Ticlopidine Approved Phase 4 55142-85-3 5472
5
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
6
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
7
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
8
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
9
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 2216-51-5 16666
10
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 439-14-5 3016
11
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
12
Simvastatin Approved Phase 4,Phase 3,Not Applicable 79902-63-9 54454
13
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
14
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
15
Phenol Approved, Experimental Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 108-95-2 996
16
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
17
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 9005-49-6 772 46507594
18
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56-81-5 753
19
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7439-89-6 23925
20
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 453 6251
21
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
22
Cabergoline Approved Phase 4,Phase 2,Phase 3,Phase 1 81409-90-7 54746
23
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
24
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 299-42-3 9294
25
Cefazolin Approved Phase 4,Phase 3,Not Applicable 25953-19-9 656510 33255
26
Ganirelix Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 123246-29-7, 124904-93-4 25081094
27
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 90-82-4 7028
28
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
29
Ofloxacin Approved Phase 4,Phase 3,Phase 2,Not Applicable 82419-36-1 4583
30
Succinylcholine Approved Phase 4 306-40-1 5314
31 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 979-32-8
32
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-83-0 5994
33
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Not Applicable 15307-86-5 3033
34
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 57-27-2 5288826
35
Formaldehyde Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-00-0 712
36
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
37
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
38
Buserelin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57982-77-1
39
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-18-0, 6055-19-2 2907
40
Tamoxifen Approved Phase 4,Phase 3,Not Applicable 10540-29-1 2733526
41
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
42
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 50-02-2 5743
43
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 112809-51-5 3902
44
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
45
Liraglutide Approved Phase 4,Not Applicable 204656-20-2 44147092
46
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
47
Goserelin Approved Phase 4,Phase 3,Phase 2,Not Applicable 65807-02-5 47725 5311128
48
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
49
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 84057-95-4 71273 175805
50
Levonorgestrel Approved, Investigational Phase 4,Not Applicable 797-63-7, 17489-40-6 13109

Interventional clinical trials:

(show top 50) (show all 4365)
# Name Status NCT ID Phase Drugs
1 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
2 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
3 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
4 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
5 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
6 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
7 Metformin in Infertile PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
8 Biosimilar Versus Urinary Gonadotropins Unknown status NCT02503605 Phase 4 Biosimilar recombinant FSH;Urinary FSH
9 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
10 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
11 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4 Human Chorionic Gonadotropin (HCG)
12 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
13 Methylprednisolone Addition in IVF Treatment of Infertile Couples Unknown status NCT01220791 Phase 4
14 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
15 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
16 Co Administration of GnRH Agonist and hCG for Final Oocyte Maturation Unknown status NCT02703584 Phase 4 Buseralin;pregnyl
17 the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer . Unknown status NCT02655146 Phase 4 triptorelin 0.1;E2;Progesterone;triptorelin 3.75mg
18 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4 Elonva;Puregon
19 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4 Corifollitropin alfa
20 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
21 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
22 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
23 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
24 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4 crinone (progesterone 8%, vaginal application)
25 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4 HCG;Lupron Trigger;Dual Trigger
26 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
27 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
28 Comparison Between Recombinant Versus Urinary hCG for Ovulation Induction in High Responders Unknown status NCT00415766 Phase 4 rHCG 250ug;uHCG 5000 IU;uHCG 7500 IU
29 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
30 Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI Unknown status NCT02696330 Phase 4 clopidogrel;enoxaparin;placebo
31 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
32 Use of G-CSF Supplemented IVF Medium in Patients Undergoing IVF Unknown status NCT02651285 Phase 4
33 Use of Corifolitropin Alfa in Oocyte Donors Unknown status NCT02213627 Phase 4 Corifollitropin alfa;Recombinant FSH;HP-hMG
34 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
35 Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF Unknown status NCT02070198 Phase 4 Long acting FSH and GnRH antagonist;Daily FSH and GnRH antagonist;Triptorelin and recombinant FSH
36 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
37 Clindamycin Once a Day in Septic Abortion Unknown status NCT02309346 Phase 4 Clindamycin
38 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
39 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
40 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Unknown status NCT02165917 Phase 4
41 The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement Unknown status NCT01312415 Phase 4 Levobupivacaine;Intrathecal morphine
42 Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate Unknown status NCT00480376 Phase 4 ofloxacin;gentamicin
43 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Unknown status NCT02601196 Phase 4 Ulipristal acetate
44 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Unknown status NCT02097017 Phase 4 Lidocaine
45 Acupuncture for Sedation in the Intensive Care Unit (ICU) Unknown status NCT01362270 Phase 4
46 Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults Unknown status NCT01967368 Phase 4 Intanza;Vaxigrip
47 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
48 Spinal Cord Stimulation (SCS) in Refractory Angina Unknown status NCT00121654 Phase 4
49 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
50 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4 Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: infertility

Sources

Genetic Tests for Infertility

About this section

Genetic tests related to Infertility:

# Genetic test Affiliating Genes
1 Infertility 29
Sources

Anatomical Context for Infertility

About this section

MalaCards organs/tissues related to Infertility:

41
Ovary, Testes, Skin, Bone, Eye, Lung, Prostate
Sources

Publications for Infertility

About this section

Articles related to Infertility:

(show top 50) (show all 3048)
# Title Authors Year
1
Nationwide survey of urological specialists regarding male infertility: results from a 2015 questionnaire in Japan. ( 29371820 )
2018
2
Infertile polycystic ovary syndrome patients undergoing in vitro fertilization with the gonadotropin-releasing hormone-antagonist protocol: role of hyperandrogenism. ( 29376451 )
2018
3
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. ( 29447380 )
2018
4
Unexplained infertility patients present the mostly impaired levels of progesterone receptors: Prospective observational study. ( 29450939 )
2018
5
How might centralization of male factor infertility care impact patients and residents? ( 29980262 )
2018
6
Changes in practice patterns in male infertility cases in the United States: the trend toward subspecialization. ( 29980267 )
2018
7
Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options. ( 29402199 )
2018
8
Role of Withania somnifera (Ashwagandha) in the management of male infertility. ( 29277366 )
2018
9
Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization. ( 29945770 )
2018
10
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. ( 29449551 )
2018
11
A Dyadic Approach to Infertility Stress, Marital Adjustment, and Depression on Quality of Life in Infertile Couples. ( 29436974 )
2018
12
Sperm retrieval rate and reproductive outcome of infertile men with azoospermia factor c deletion. ( 29920741 )
2018
13
IL-1E9 C376A Transversion Variant and Risk of Idiopathic Male Infertility in Iranian Men: A Genetic Association Study. ( 29935069 )
2018
14
Mapping Out the under-Recognized Burden of Human Infertility Linked to<i>Schistosoma haematobium</i>Infection. ( 29405110 )
2018
15
Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility. ( 29516876 )
2018
16
Fear and infertility research. ( 29419382 )
2018
17
Point-of-care whole-exome sequencing of idiopathic male infertility. ( 29790874 )
2018
18
Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice. ( 29907856 )
2018
19
Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men. ( 29292525 )
2018
20
Usefulness of Testicular Volume, Apparent Diffusion Coefficient, and Normalized Apparent Diffusion Coefficient in the MRI Evaluation of Infertile Men With Azoospermia. ( 29364721 )
2018
21
Application of induced pluripotent stem cell and embryonic stem cell technology to the study of male infertility. ( 29870061 )
2018
22
Assessment of seminal granulysin in infertile men with varicocele. ( 29896906 )
2018
23
Efficacy of GnRH agonist trigger in women having history of follicular-endometrial asynchrony with clomiphene/IUI cycles in unexplained infertility. ( 29955952 )
2018
24
A homozygous FANCM frameshift pathogenic variant causes male infertility. ( 29895858 )
2018
25
The relationship between stress and infertility. ( 29946210 )
2018
26
Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1. ( 29808481 )
2018
27
Molecular mimicry: An explanation for autoimmune diseases and infertility. ( 29935034 )
2018
28
Infertility and recurrent miscarriage in a patient with autoimmune atrophic gastritis. ( 29524079 )
2018
29
Association of the c.-9C&amp;gt;T and c.368A&amp;gt;G transitions in H2BFWT gene with male infertility in an Iranian population. ( 28370107 )
2018
30
Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial. ( 29770466 )
2018
31
Evaluation of the Sysmex UF-1000i system as an alternative for the screening of genital tract inflammation in male infertility patients. ( 29806204 )
2018
32
Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece. ( 29928881 )
2018
33
Male Infertility Diagnosis and Treatment in the Era of InA Vitro Fertilization and Intracytoplasmic Sperm Injection. ( 29406062 )
2018
34
Varicocele management for infertility and pain: A systematic review. ( 29713547 )
2018
35
Influence of all-trans retinoic acid on sperm metabolism and oxidative stress: Its involvement in the physiopathology of varicocele-associated male infertility. ( 29943815 )
2018
36
Comprehensive genetic testing for female and male infertility using next-generation sequencing. ( 29779145 )
2018
37
An Association Study between Longitudinal Changes of Leukocyte Telomere and the Risk of Azoospermia in a Population of Iranian Infertile Men ( 29704891 )
2018
38
Can Tangier disease cause male infertility? A case report and an overview on genetic causes of male infertility and hormonal axis involved. ( 29198592 )
2018
39
Bilateral is superior to unilateral varicocelectomy in infertile males with left clinical and right subclinical varicocele: a prospective randomized controlled study. ( 29210007 )
2018
40
Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon. ( 29931406 )
2018
41
IL-1RA VNTR and IL-1I+ 4845G&amp;gt;T polymorphisms and risk of idiopathic male infertility in Iranian men: A case-control study and an in silico analysis. ( 29968322 )
2018
42
A case report of successful pregnancy and delivery after peritoneal dialysis in a patient misdiagnosed with primary infertility. ( 29952961 )
2018
43
The effect of low-dose ovarian stimulation with HMG plus progesterone on pregnancy outcome in women with history of recurrent pregnancy loss and secondary infertility: a retrospective cohort study. ( 29433402 )
2018
44
Spirituality, infertility-related stress, and quality of life in Brazilian infertile couples: Analysis using the actor-partner interdependence mediation model. ( 29399819 )
2018
45
Cytological diagnosis of a testicular tumour in an infertile male which mimicked epididymitis. ( 29863791 )
2018
46
Positive and negative adjustment in couples undergoing infertility treatment: The impact of support exchange. ( 29953537 )
2018
47
Amenorrhoea and reversible infertility due to obstructive hydrocephalus: literature review and case report. ( 29430977 )
2018
48
Magnetic resonance hysterosalpingography in diagnostic work-up of female infertility - comparison with conventional hysterosalpingography: a randomised study. ( 29974219 )
2018
49
The association of thyroid function and autoimmunity with ovarian reserve in women seeking infertility care. ( 29943679 )
2018
50
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia. ( 29365104 )
2018
Sources

Variations for Infertility

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ClinVar genetic disease variations for Infertility:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NPHP4 NM_015102.4(NPHP4): c.2044C> T (p.Arg682Ter) single nucleotide variant Pathogenic/Likely pathogenic rs137852920 GRCh37 Chromosome 1, 5964776: 5964776
2 NPHP4 NM_015102.4(NPHP4): c.2044C> T (p.Arg682Ter) single nucleotide variant Pathogenic/Likely pathogenic rs137852920 GRCh38 Chromosome 1, 5904716: 5904716

Copy number variations for Infertility from CNVD:

7 (show all 50)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion AZFb infertility
13 266750 Y 1 57772954 Microdeletion AZFc infertility
14 266796 Y 11300000 27200000 Deletion AZF infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZFa infertility
17 266827 Y 11300000 27200000 Microdeletion AZFb infertility
18 266828 Y 11300000 27200000 Microdeletion AZFc infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4LY infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion GOLGAZLY infertility
27 266840 Y 11300000 27200000 Microdeletion NAHR infertility
28 266841 Y 11300000 27200000 Microdeletion NOA infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF infertility
32 266975 Y 174481503 174538309 Microdeletions AZF infertility
33 266976 Y 174481503 174538309 Microdeletions AZFA infertility
34 267088 Y 23407118 25740308 Copy number TTTY17 Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4LY Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation ATPase6 Infertility
49 267527 mtDNA 1 16569 Mutation CYTB Infertility
50 267528 1 183532144 183553084 Mutation ND1 Infertility
Sources

Expression for Infertility

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Search GEO for disease gene expression data for Infertility.
Sources

Pathways for Infertility

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Pathways related to Infertility according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 66
11.83 FSHB FSHR LHB LHCGR
2
Fertilization 66
Show member pathways
 11.44 CATSPER1 CATSPER2 ZP1 ZP3
3
Ovarian steroidogenesis 37
11.24 CYP19A1 FSHB FSHR LHB LHCGR
4
Follicle Stimulating Hormone (FSH) signaling pathway 1
10.93 CYP19A1 FSHB FSHR
5
Transcription_CREM signaling in testis 22
10.77 FSHB FSHR
6
Ovarian Infertility Genes 1
10.67 CYP19A1 DAZL FSHR INHA LHCGR NR5A1
7
Hormone ligand-binding receptors 66
10.37 FSHB FSHR LHB LHCGR
Sources

GO Terms for Infertility

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Cellular components related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.26 CATSPER1 CATSPER2 DNAH1 NPHP4
2 CatSper complex GO:0036128 8.62 CATSPER1 CATSPER2

Biological processes related to Infertility according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.9 FSHB INHA LHB NR5A1
2 single fertilization GO:0007338 9.75 SPAG1 ZP1 ZP3
3 male gonad development GO:0008584 9.72 FSHR INHA LHB LHCGR NR5A1
4 germ cell development GO:0007281 9.7 DAZ1 DAZ4 DAZL
5 flagellated sperm motility GO:0030317 9.67 CATSPER1 CATSPER2 DNAH1 NPHP4
6 positiv