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MCID: INF032
MIFTS: 57

Infertility

Categories: Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Infertility

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MalaCards integrated aliases for Infertility:

Name: Infertility 12 29 54 6 42 3 43 15 62 17 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5223
MeSH 43 D007246
NCIt 49 C3836
SNOMED-CT 67 15296000 8619003
UMLS 71 C0021359
Sources

Summaries for Infertility

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MedlinePlus : 42 Infertility means not being able to become pregnant after a year of trying. If a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. Infertility is fairly common. After one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. About a third of the time, infertility can be traced to the woman. In another third of cases, it is because of the man. The rest of the time, it is because of both partners or no cause can be found. There are treatments that are specifically for men or for women. Some involve both partners. Drugs, assisted reproductive technology, and surgery are common treatments. Happily, many couples treated for infertility go on to have babies. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Infertility is related to male infertility and spermatogenic failure 5, and has symptoms including pelvic pain An important gene associated with Infertility is NPHP4 (Nephrocystin 4), and among its related pathways/superpathways are cAMP signaling pathway and G alpha (s) signalling events. The drugs Clopidogrel and Heparin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and uterus, and related phenotypes are cellular and endocrine/exocrine gland

CDC : 3 In general, infertility is defined as not being able to get pregnant (conceive) after one year (or longer) of unprotected sex. Because fertility in women is known to decline steadily with age, some providers evaluate and treat women aged 35 years or older after 6 months of unprotected sex. Women with infertility should consider making an appointment with a reproductive endocrinologist-a doctor who specializes in managing infertility. Reproductive endocrinologists may also be able to help women with recurrent pregnancy loss, defined as having two or more spontaneous miscarriages.

PubMed Health : 62 About infertility: Not being able to have children is often a source of great emotional turmoil. Many men and women take it for granted that they will be able to have children. If they are not able to conceive, many couples start looking for medical help at some point. A number of different treatments are available, depending on the possible causes of infertility. Problems conceiving a child are defined by medical experts as “infertility” if a couple has had regular unprotected sex for one year without the woman becoming pregnant.

Wikipedia : 74 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

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Related Diseases for Infertility

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Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1097)
# Related Disease Score Top Affiliating Genes
1 male infertility 34.8 NPHP4 INHA FSHR EPPIN DNAH1 DAZL
2 spermatogenic failure 5 34.5 DPY19L2 AURKC
3 female infertility due to zona pellucida defect 34.3 ZP3 ZP2
4 catsper-related male infertility 34.3 CATSPER2 CATSPER1
5 non-syndromic male infertility due to sperm motility disorder 34.2 DNAH1 CATSPER1
6 spermatogenic failure 9 33.8 EPPIN DPY19L2 DNAH1 AURKC
7 oligoasthenoteratozoospermia 33.4 DAZL CATSPER2 CATSPER1
8 hypogonadotropic hypogonadism 33.4 NR5A1 LHCGR LHB FSHB CYP19A1
9 primary ciliary dyskinesia 33.2 SPAG1 NPHP4 DPY19L2 DNAH1 CATSPER1
10 premature ovarian failure 1 33.1 ZP3 ZP2 NR5A1 LHCGR INHA FSHR
11 cryptorchidism, unilateral or bilateral 33.1 NR5A1 LHCGR FSHR EPPIN DAZL CYP19A1
12 anovulation 33.1 FSHR FSHB CYP19A1
13 46,xx sex reversal 1 32.7 NR5A1 FSHR
14 hypogonadotropic hypogonadism 23 without anosmia 32.7 LHB EPPIN
15 hypogonadism 32.1 LHCGR LHB FSHB CYP19A1
16 ovarian hyperstimulation syndrome 31.9 LHCGR FSHR FSHB CYP19A1
17 amenorrhea 31.8 NR5A1 LHCGR LHB FSHR FSHB CYP19A1
18 ovarian disease 31.5 ZP3 NR5A1 LHCGR INHA FSHR EPPIN
19 leydig cell tumor 31.2 NR5A1 LHCGR INHA CYP19A1
20 premature menopause 31.2 FSHR EPPIN CYP19A1
21 precocious puberty 31.0 LHCGR CYP19A1
22 estrogen excess 30.8 FSHR EPPIN CYP19A1
23 sex development disorder 30.8 NR5A1 LHCGR FSHR CYP19A1
24 twinning, dizygotic 30.6 INHA FSHR
25 prostatic cyst 30.6 FSHR EPPIN
26 46 xx gonadal dysgenesis 30.6 NR5A1 LHCGR FSHR
27 adrenal rest tumor 30.6 NR5A1 EPPIN
28 pseudohermaphroditism 30.6 NR5A1 LHCGR LHB FSHR EPPIN CYP19A1
29 mucinous cystadenofibroma 30.4 LHCGR FSHR
30 germ cell cancer 29.8 LHCGR H19 FSHR
31 choriocarcinoma 29.2 INHA H19 CYP19A1
32 trophoblastic neoplasm 29.1 INHA H19
33 deafness-infertility syndrome 12.6
34 y chromosome infertility 12.6
35 male infertility with teratozoospermia due to single gene mutation 12.4
36 catsper1-related nonsyndromic male infertility 12.4
37 spermatogenic failure 6 12.3
38 male infertility due to obstructive azoospermia 12.3
39 male infertility due to sperm motility disorder 12.3
40 female infertility of uterine origin 12.2
41 rare female infertility due to hypothalamic-pituitary-gonadal axis disorder of genetic origin 12.2
42 rare female infertility due to hypothalamic-pituitary-gonadal axis disorder 12.2
43 rare male infertility due to hypothalamic-pituitary-gonadal axis disorder of genetic origin 12.2
44 rare male infertility due to hypothalamic-pituitary-gonadal axis disorder 12.2
45 rare female infertility due to gonadal dysgenesis 12.2
46 rare female infertility due to a congenital hypogonadotropic hypogonadism 12.2
47 male infertility with spermatogenesis disorder due to single gene mutation 12.2
48 male infertility due to obstructive azoospermia of genetic origin 12.2
49 male infertility due to gonadal dysgenesis or sperm disorder 12.2
50 rare female infertility due to an implantation defect 12.1

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility
Sources

Symptoms & Phenotypes for Infertility

About this section

UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.93 CATSPER1 CATSPER2 CYP19A1 DPY19L2 FSHB FSHR
2 endocrine/exocrine gland MP:0005379 9.65 CYP19A1 DPY19L2 FSHB FSHR INHA LHB
3 reproductive system MP:0005389 9.5 AURKC CATSPER1 CATSPER2 CYP19A1 DNAH1 DPY19L2
Sources

Drugs & Therapeutics for Infertility

About this section

PubMed Health treatment related to Infertility: 62

There are a number of different treatments for infertility . The exact kind of treatment will mainly be determined by what sort of problem has been diagnosed in the woman or man. For instance, hormones may be used if the woman has an abnormal menstrual cycle . Surgery may be helpful if she has fibroids . Some causes of infertility in men can also be treated with hormones or surgery. If not enough sperm is produced or if the sperm cells don't move enough, the semen can be transferred directly to the woman’s womb . This procedure is called insemination. Artificial insemination is also a treatment option if the couple can't have sex or if the sperm can't pass through the cervical mucus . One alternative is artificial fertilization outside the body (in vitro fertilization, or IVF): In this procedure, eggs are removed from the woman’s ovaries through the vagina using a thin hollow needle, and then combined with sperm from the man. Before the eggs are removed, the woman has hormone therapy to stimulate her ovaries to release several mature eggs during the course of a single menstrual cycle . This hormone therapy can have very strong and unpleasant side effects. The actual fertilization takes place outside of the woman's body in a laboratory. In IVF, sperm cells are added to an egg cell and the fertilization process happens on its own. In intracytoplasmic sperm injection (ICSI), one sperm cell is injected directly into an egg using a fine needle. If the fertilization is a success and the egg cells continue to develop, the doctor implants up to three embryos into the womb . In rare cases more egg cells develop into embryos. The woman can then decide to have them frozen (cryopreserved) or destroyed. This also applies to egg cells in a stage of development called the pronuclear stage, in which the chromosome sets from the sperm and egg cells have not yet fully joined together. Cryopreserved embryos or fertilized egg cells can then be thawed out for use in a later cycle if the first transfer is not successful.

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 557)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Calcium polycarbophil Approved Phase 4 126040-58-2
7
Nafarelin Approved Phase 4 76932-56-4 16129618 25077649
8
Simvastatin Approved Phase 4 79902-63-9 54454
9
Danazol Approved Phase 4 17230-88-5 28417
10
Atosiban Approved, Investigational Phase 4 90779-69-4
11
Meperidine Approved Phase 4 57-42-1 4058
12
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
13
Saw palmetto Approved, Experimental, Investigational Phase 4
14
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
15
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
16
Miglustat Approved Phase 4 72599-27-0 51634
17
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
18
Cefixime Approved, Investigational Phase 4 79350-37-1 54362 5362065
19
Gemifloxacin Approved, Investigational Phase 4 175463-14-6 5464436 9571107
20
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
21
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
22
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
23
leucovorin Approved Phase 4 58-05-9 6006 143
24
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
25
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
26
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
27
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
28
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
29 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
30
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
31
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
32 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
33
Dimenhydrinate Approved Phase 4 523-87-5 441281
34
Norepinephrine Approved Phase 4 51-41-2 439260
35
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
36
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
37 Bemiparin Approved, Investigational Phase 4 91449-79-5
38
Cytarabine Approved, Experimental, Investigational Phase 4 147-94-4, 65-46-3 6253
39
Etoposide Approved Phase 4 33419-42-0 36462
40
Estrone Approved Phase 4 53-16-7 5870
41
Trimethobenzamide Approved, Investigational Phase 4 138-56-7 5577
42
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
43
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
44
Cabergoline Approved Phase 4 81409-90-7 54746
45
Menotropins Approved Phase 4 9002-68-0, 61489-71-2 5360545
46
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
47
Enoxaparin Approved Phase 4 9005-49-6 772
48
Acetaminophen Approved Phase 4 103-90-2 1983
49
tannic acid Approved Phase 4 1401-55-4
50
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show top 50) (show all 2304)
# Name Status NCT ID Phase Drugs
1 Transdermal Testosterone for Poor Responders Undergoing IVF Unknown status NCT03078569 Phase 4 Testosterone gel
2 Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial. Unknown status NCT02140398 Phase 4
3 A Prospective Randomized Trial to Analyze the Effect of the Gonadotropin Administered During Control Ovarian Stimulation on Embryo Kinetics of Development Unknown status NCT02402192 Phase 4 Corifollitropin alfa
4 The Effect of LH-Priming During Early Follicular Phase on Ovarian Response and Pregnancy Outcome in GnRHa Down-Regulated Women, Stimulated With Exogenous Gonadotrophins in IVF Treatment Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
5 Clinical Study of the Treatment of Infertility Caused by Severe Intrauterine Adhesions by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
6 Structured Exerise Training in Infertile Obese Patients Treated With Assisted Reproductive Techniques: a Randomized Controlled Trial Unknown status NCT01892111 Phase 4
7 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4 Human Chorionic Gonadotropin (HCG)
8 Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
9 Prospective Randomized Trial on GnRH Agonist Triggering Versus hCG Triggering in IVF Stimulation in PCOS Patients Unknown status NCT01683513 Phase 4 GnRh agonist +1500E hCG
10 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial Unknown status NCT01992731 Phase 4
11 Metformin for the Treatment of Unexplained Oligozspermia and Azoospermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
12 Effectiveness and Safety of uFSH for Severe Oligospermia or Azoospermia:A Multi-center,Open,Randomized,Interventional,and Phase4 Trial in China Unknown status NCT02307994 Phase 4 75IU uFSH
13 An Interventional Study to Assess the Efficacy and Safety of Gonapure® in Multifollicular Stimulation in Egyptian Women Undergoing IVF/ICSI Unknown status NCT03057574 Phase 4 Follitropin Alfa
14 The Effect of Intracervical Lidocaine Versus Intramuscular Diclofenac for Pain Relief During Hysterosalpingography Among Infertile Women In A Tertiary Hospital In Kano: A Randomized Controlled Trial Unknown status NCT02918812 Phase 4 Intracervical lidocaine;Intramuscular Diclofenac
15 Effects of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer Unknown status NCT03309436 Phase 4 Clomiphene Citrate protocol
16 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
17 Prospective Randomized Clinical Trial to Test the Efficacy of a Biosimilar Recombinant Follicle Stimulating Hormone (FSH)vs. Urinary FSH in an Oocyte Donation Program Unknown status NCT02503605 Phase 4 Biosimilar recombinant FSH;Urinary FSH
18 Improving Oocyte Retrieval Using a Combined Therapy of Recombinant Follicle Stimulating Hormone (rFSH) and Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
19 Luteal Phase Support With Progesterone vs Estrogen and Progesterone on Pregnancy Rates in Ovarian Stimulation and Intrauterine Insemination Cycles: a Prospective Randomized Study Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
20 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
21 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
22 Randomized Controlled Trial Comparing the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation in Normal Responders Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
23 Administration of Human Chorionic Gonadotropin (hCG) Versus Gonadotropin Releasing Hormone (GnRH) Agonist for Ovulation Induction in Hyper-Responder Patients Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
24 Recombinant hCG (Ovitrelle) Vesrus Urinary hCG (Pregnyl) for Triggering Final Oocyte Maturation in High Responders Unknown status NCT00415766 Phase 4 rHCG 250ug;uHCG 5000 IU;uHCG 7500 IU
25 Co Administration of GnRH Agonist and hCG for Final Oocyte Maturation- A Randomized Controlled Trial Unknown status NCT02703584 Phase 4 Buseralin;pregnyl
26 Comparison of Tamoxifen and Clomiphene Citrate in Mild Stimulation IVF: a Prospective Cohort Study Unknown status NCT02690870 Phase 4 Tamoxifen;Clomiphene
27 PERCING : Ovarian Drilling Versus Ovarian Stimulation + Intra Uterine Insemination (IUI) + Metformin in the PCOS (PolyCystic Ovaries Syndrome) Treatment Unknown status NCT00378729 Phase 4 Metformin and FSHr
28 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation by Using Recombinant Luteinizing Hormone (rLH) and Recombinant Follicle Stimulating Hormone (rFSH) in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
29 Adding L-carnitine in Clomiphene Resistant Pco Improves the Quality of Ovulation and the Pregnancy Outcome,a Randomized Clinical Trial Unknown status NCT01665547 Phase 4 l-carnitine
30 The Comparison of Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders: a Prospective Randomized Study. Unknown status NCT01926210 Phase 4
31 Corifollitropin Alfa (Elonva) Versus Follitropin Beta in High Responders: A Randomized Controlled Trial Unknown status NCT02471677 Phase 4 Elonva;Puregon
32 G-CSF Supplemented Medium for IVF Embryo Culture in Patients Undergoing IVF Unknown status NCT02651285 Phase 4
33 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
34 Long Acting FSH Plus GnRH Antagonist Versus Daily FSH Plus GnRH Antagonist Versus Short Agonist Regimens in Poor Responder Patients Undergoing IVF: a Randomized Study. Unknown status NCT02070198 Phase 4 Long acting FSH and GnRH antagonist;Daily FSH and GnRH antagonist;Triptorelin and recombinant FSH
35 The Effect of UPA on Women Ovarian Reserve Unknown status NCT02361892 Phase 4 ulipristal acetate
36 A Comparison Study of a Novel Stimulation Protocol With Metformin in Step-down Regimen and the Conventional Low Dose Step-up Protocol in Patients With Polycystic Ovary Syndrome Undergoing in Vitro Fertilization Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
37 Subcutaneous Versus Vaginal Progesterone as Luteal Support in IVF/ICSI Cycles: Which is the Preference Expressed by the Patients? Unknown status NCT03181685 Phase 4 Progesterone 25 MG subcutaneous;Micronized progesterone 200 MG;recombinant FSH;Cetrorelix Acetate
38 Concomitant Clomiphene Citrate and Estradiol Versus Clomiphene Citrate Alone in Ovulation Induction: a Randomized Controlled Trial Unknown status NCT02186782 Phase 4 Clomiphene citrate and Estradiol;Clomiphene citrate and Placebo
39 Implantation in Frozen Embryo Transfer Unknown status NCT02655146 Phase 4 triptorelin 0.1;E2;Progesterone;triptorelin 3.75mg
40 Effectiveness of Self-cross-linked Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion Unknown status NCT02868437 Phase 4
41 Comparison of Clinical Pregnancy Rates Between Two Protocols, With or Without Low Molecular Weight Heparin Administration Before Frozen Embryo Transfer in Hormonal Replacement Cycles: a Prospective Randomized Controlled Trial Unknown status NCT03120715 Phase 4 estrogen;Low Molecular Weight Heparin;hCG;progesterone
42 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Unknown status NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
43 Ulipristal Acetate Versus GnRH Analogue for Myometrial Preservation in Patients With Submucosal Uterine Leiomyoma G2 Unknown status NCT02357563 Phase 4 ulipristal acetate;Leuprolide acetate
44 Comparison of Intravaginal Misoprostol and Dinoprostol for the Purpose of Cervical Ripening Before Diagnostic Hysteroscopy in the Women at the Reproductive Age:RANDOMİSED,CONTROLLED PROSPECTİVE TRİAL Unknown status NCT01620814 Phase 4 Dinoprostone;misoprostol;control
45 Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI Unknown status NCT02696330 Phase 4 clopidogrel;enoxaparin;placebo
46 Randomized, Multicentric and Prospective Clinical Trial to Check the Cost-effectiveness of Corifollitropin Alfa vs. Recombinant FSH and/or HP-hMG Unknown status NCT02213627 Phase 4 Corifollitropin alfa;Recombinant FSH;HP-hMG
47 Effect of Endometrial Injury Before Frozen Embryo Transfer on Pregnancy Rate Unknown status NCT03220503 Phase 4
48 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 11 With and Without Suppression by Dienogest Unknown status NCT02575248 Phase 4 Dienogest 2mg;Clomiphene citrate 5 mg
49 Efficacy of Long- Versus Short-term Metformin Protocol in Infertile Anovulatory PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
50 Randomised, Controlled Clinical Study With Patients With Endometriosis and the Desire to Have Children - Comparison Between Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesionbarrier Unknown status NCT02165917 Phase 4

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 71 / NDF-RT 50 :


2-Bromoergocryptine Mesylate
Bromocriptine
Follicle Stimulating Hormone
Follitropin Alfa
follitropin beta
Leuprolide
Leuprolide Acetate
Sermorelin
Sermorelin Acetate

Cochrane evidence based reviews: infertility

Sources

Genetic Tests for Infertility

About this section

Genetic tests related to Infertility:

# Genetic test Affiliating Genes
1 Infertility 29
Sources

Anatomical Context for Infertility

About this section

MalaCards organs/tissues related to Infertility:

40
Ovary, Testes, Uterus, Testis, Pituitary, Breast, Thyroid
Sources

Publications for Infertility

About this section

Articles related to Infertility:

(show top 50) (show all 30183)
# Title Authors PMID Year
1
Too much time? Time use and fertility-specific quality of life among men and women seeking specialty care for infertility. 61 42
31288855 2019
2
Reproduction, rethought. 42
31680127 2019
3
Re: Parental Subfertility and Hypospadias and Cryptorchidism in Boys: Results from Two Danish Birth Cohorts. 42
31287358 2019
4
Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. 54 61
20357175 2010
5
A 46, XX SRY - negative man with infertility, and co-existing with chronic autoimmune thyroiditis. 54 61
20170343 2010
6
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis. 54 61
19342032 2010
7
Expression of macrophage migration inhibitory factor in human endometriosis: relation to disease stage, menstrual cycle and infertility. 54 61
20492386 2010
8
Comparison of mild stimulation and conventional stimulation in ART outcome. 54 61
19834718 2010
9
A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. 54 61
19863670 2010
10
Evaluation of the leptin receptor in human spermatozoa. 54 61
20178606 2010
11
Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSH. 54 61
20061434 2010
12
Trafficking and signalling of gonadotrophin-releasing hormone receptors: an automated imaging approach. 54 61
19888967 2010
13
FOXL2 mutations lead to different ovarian phenotypes in BPES patients: Case Report. 54 61
19819892 2010
14
Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature. 54 61
18996517 2010
15
HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility. 54 61
19736237 2009
16
Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment. 54 61
19118825 2009
17
Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice. 54 61
18980760 2009
18
Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population. 54 61
19937586 2009
19
Male infertility and the involvement of the X chromosome. 54 61
19515807 2009
20
Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial. 54 61
18692823 2009
21
Estrogen receptor beta gene mutations in Indian infertile men. 54 61
19509112 2009
22
The role of prolactin- and endometriosis-associated infertility. 54 61
19624865 2009
23
Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy. 54 61
19647472 2009
24
Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility. 54 61
18774560 2009
25
Length of androgen receptor-CAG repeats in fertile and infertile Egyptian men. 54 61
19168451 2009
26
Aromatase inhibitors for ovulation and pregnancy in polycystic ovary syndrome. 54 61
19584394 2009
27
Disturbances in the LIF pathway in the endometrium among women with unexplained infertility. 54 61
18684446 2009
28
The cystic fibrosis transmembrane conductance regulator in reproductive health and disease. 54 61
19015188 2009
29
Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities. 54 61
18439585 2009
30
Is aromatase expression in the endometrium the cause of endometriosis and related infertility? 54 61
19340622 2009
31
Influence of polymorphism of glutathione S-transferase T1 on Chinese infertile patients with varicocele. 54 61
18163994 2009
32
Peritoneal fluid and serum leptin concentrations in women with primary infertility. 54 61
18665375 2009
33
CA repeat and RsaI polymorphisms in ERbeta gene are not associated with infertility in Indian men. 54 61
17916182 2009
34
Spermatogenesis in a man with complete deletion of USP9Y. 54 61
19246359 2009
35
Androgen receptor knockout and knock-in mouse models. 54 61
18923000 2009
36
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. 54 61
19129711 2009
37
Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility. 54 61
19089782 2009
38
Leukaemia inhibitory factor (LIF) gene mutations in women diagnosed with unexplained infertility and endometriosis have a negative impact on the IVF outcome. A pilot study. 54 61
19545488 2009
39
Status of serum leptin levels in females with infertility. 54 61
18946565 2008
40
Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility. 54 61
17919612 2008
41
First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation. 54 61
18164000 2008
42
Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility. 54 61
18567645 2008
43
Recombinant HCG for triggering ovulation increases the rate of mature oocytes in women treated for ICSI. 54 61
18925430 2008
44
A relationship between increased peritoneal leptin levels and infertility in endometriosis. 54 61
18958774 2008
45
Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm-zona pellucida interaction. 54 61
17936279 2008
46
Factors affecting live birth rate in intrauterine insemination cycles with recombinant gonadotrophin stimulation. 54 61
18681993 2008
47
A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister. 54 61
18508780 2008
48
The AZF proteins. 54 61
18462373 2008
49
Treatment of unexplained infertility with aromatase inhibitors or clomiphene citrate: a systematic review and meta-analysis. 54 61
18559123 2008
50
Purification and characterization of biologically active recombinant human Eppin expressed in Escherichia coli. 54 61
18466682 2008
Sources

Variations for Infertility

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ClinVar genetic disease variations for Infertility:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NPHP4 NM_015102.5(NPHP4):c.2044C>T (p.Arg682Ter)SNV Pathogenic/Likely pathogenic 3401 rs137852920 1:5964776-5964776 1:5904716-5904716
2 MYO6 NM_004999.4(MYO6):c.3176G>C (p.Arg1059Thr)SNV Uncertain significance 45153 rs202214380 6:76608128-76608128 6:75898411-75898411

Copy number variations for Infertility from CNVD:

7 (show all 50)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion AZFb infertility
13 266750 Y 1 57772954 Microdeletion AZFc infertility
14 266796 Y 11300000 27200000 Deletion AZF infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZFa infertility
17 266827 Y 11300000 27200000 Microdeletion AZFb infertility
18 266828 Y 11300000 27200000 Microdeletion AZFc infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4LY infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion GOLGAZLY infertility
27 266840 Y 11300000 27200000 Microdeletion NAHR infertility
28 266841 Y 11300000 27200000 Microdeletion NOA infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF infertility
32 266975 Y 174481503 174538309 Microdeletions AZF infertility
33 266976 Y 174481503 174538309 Microdeletions AZFA infertility
34 267088 Y 23407118 25740308 Copy number TTTY17 Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4LY Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation ATPase6 Infertility
49 267527 mtDNA 1 16569 Mutation CYTB Infertility
50 267528 1 183532144 183553084 Mutation ND1 Infertility
Sources

Expression for Infertility

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Search GEO for disease gene expression data for Infertility.
Sources

Pathways for Infertility

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Pathways related to Infertility according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
cAMP signaling pathway 36
12.04 LHCGR LHB FSHR FSHB
2
G alpha (s) signalling events 65
11.83 LHCGR LHB FSHR FSHB
3
Fertilization 65
Show member pathways
 11.44 ZP3 ZP2 CATSPER2 CATSPER1
4
Ovarian steroidogenesis 36
11.24 LHCGR LHB FSHR FSHB CYP19A1
5
Follicle Stimulating Hormone (FSH) signaling pathway 1
10.93 FSHR FSHB CYP19A1
6
Transcription_CREM signaling in testis 22
10.79 FSHR FSHB
7
Ovarian Infertility Genes 1
10.73 ZP3 ZP2 NR5A1 LHCGR INHA FSHR
8
Hormone ligand-binding receptors 65
10.37 LHCGR LHB FSHR FSHB
Sources

GO Terms for Infertility

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Cellular components related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.56 NPHP4 DNAH1 CATSPER2 CATSPER1
2 motile cilium GO:0031514 9.33 DNAH1 CATSPER2 CATSPER1
3 CatSper complex GO:0036128 8.96 CATSPER2 CATSPER1
4 egg coat GO:0035805 8.62 ZP3 ZP2

Biological processes related to Infertility according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.01 NR5A1 INHA DPY19L2 DAZL CATSPER2 CATSPER1
2 spermatogenesis GO:0007283 9.8 FSHR DPY19L2 DAZL CATSPER2 CATSPER1 AURKC
3 single fertilization GO:0007338 9.65 ZP3 ZP2 SPAG1
4 female gamete generation GO:0007292 9.58 FSHR FSHB
5 peptide hormone processing GO:0016486 9.57 LHB FSHB
6 oocyte maturation GO:0001556 9.56 TUBB8 DAZL
7 uterus development GO:0060065 9.55 FSHR CYP19A1
8 regulation of osteoclast differentiation GO:0045670 9.52 FSHR FSHB
9 sperm-egg recognition GO:0035036 9.51 CATSPER2 CATSPER1
10 oocyte development GO:0048599 9.49 ZP3 AURKC
11 Sertoli cell proliferation GO:0060011 9.46 FSHR FSHB
12 flagellated sperm motility GO:0030317 9.46 NPHP4 DNAH1 CATSPER2 CATSPER1
13 ovulation cycle process GO:0022602 9.43 LHCGR FSHR
14 female gonad development GO:0008585 9.43 NR5A1 FSHR CYP19A1
15 follicle-stimulating hormone signaling pathway GO:0042699 9.4 FSHR FSHB
16 progesterone biosynthetic process GO:0006701 9.37 LHB FSHB
17 male gonad development GO:0008584 9.35 NR5A1 LHCGR