MCID: INF032
MIFTS: 59

Infertility

Categories: Reproductive diseases
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Aliases & Classifications for Infertility

MalaCards integrated aliases for Infertility:

Name: Infertility 11 28 53 5 41 2 43 14 63 38 16 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:5223
MeSH 43 D007246
NCIt 49 C3836
SNOMED-CT 68 8619003
UMLS 71 C0021359

Summaries for Infertility

MedlinePlus: 41 Infertility means not being able to become pregnant after a year of trying. If a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. Infertility is fairly common. After one year of having unprotected sex, about 15% of couples are unable to get pregnant. About a third of the time, infertility can be traced to the woman. In another third of cases, it is because of the man. The rest of the time, it is because of both partners or no cause can be found. There are treatments that are specifically for men or for women. Some involve both partners. Drugs, assisted reproductive technology, and surgery are common treatments. Happily, many couples treated for infertility go on to have babies. NIH: National Institute of Child Health and Human Development

MalaCards based summary: Infertility is related to male infertility and female infertility due to zona pellucida defect, and has symptoms including pelvic pain An important gene associated with Infertility is DNAH5 (Dynein Axonemal Heavy Chain 5), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and G alpha (s) signalling events. The drugs Dinoprostone and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and pituitary, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

CDC: 2 In general, infertility is defined as not being able to get pregnant (conceive) after one year (or longer) of unprotected sex. Because fertility in women is known to decline steadily with age, some providers evaluate and treat women aged 35 years or older after 6 months of unprotected sex. Women with infertility should consider making an appointment with a reproductive endocrinologist-a doctor who specializes in managing infertility. Reproductive endocrinologists may also be able to help women with recurrent pregnancy loss, defined as having two or more spontaneous miscarriages.

PubMed Health : 63 Infertility: Not being able to have children is often a source of great emotional turmoil. Many men and women take it for granted that they will be able to have children. If they are not able to conceive, many couples start looking for medical help at some point. A number of different treatments are available, depending on the possible causes of infertility. Problems conceiving a child are defined by medical experts as “infertility” if a couple has had regular unprotected sex for one year without the woman becoming pregnant.

Wikipedia: 75 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

Related Diseases for Infertility

Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1336)
# Related Disease Score Top Affiliating Genes
1 male infertility 33.4 NPHP4 INHA FSHR EPPIN DNAH5 DAZL
2 female infertility due to zona pellucida defect 32.8 ZP3 ZP2
3 polycystic ovary syndrome 32.7 LHCGR FSHR FSHB CYP19A1
4 spermatogenic failure, y-linked, 2 32.6 DAZL DAZ4 DAZ1
5 partial deletion of y 32.6 DAZ4 DAZ1
6 spermatogenic failure 32.6 TUBB8 NR5A1 LHCGR GNRHR FSHR FSHB
7 anovulation 32.4 LHCGR FSHR FSHB CYP19A1
8 endometriosis 32.4 NR5A1 H19 GNRHR FSHR CYP19A1
9 premature ovarian failure 1 32.3 INHA FSHR DAZL
10 oligospermia 32.0 GNRHR EPPIN DAZL DAZ4
11 androgen insensitivity, partial 32.0 NR5A1 EPPIN CYP19A1
12 blepharophimosis, ptosis, and epicanthus inversus 31.9 NR5A1 GNRHR CYP19A1
13 46,xx sex reversal 1 31.9 NR5A1 FSHR
14 premature menopause 31.8 ZP3 ZP2 TUBB8 TAC3 NR5A1 LHCGR
15 hypogonadotropic hypogonadism 31.8 TAC3 NR5A1 LHCGR INHA GNRHR FSHR
16 hypogonadotropic hypogonadism 23 with or without anosmia 31.8 GNRHR EPPIN
17 cryptorchidism, unilateral or bilateral 31.7 TAC3 NR5A1 LHCGR GNRHR FSHR FSHB
18 leydig cell hypoplasia 31.7 NR5A1 LHCGR GNRHR FSHR EPPIN
19 ovarian hyperstimulation syndrome 31.7 LHCGR FSHR FSHB CYP19A1
20 ovarian disease 31.6 ZP3 LHCGR FSHR EPPIN CYP19A1
21 testicular disease 31.4 LHCGR EPPIN DAZL CYP19A1
22 amenorrhea 31.4 NR5A1 LHCGR GNRHR FSHR FSHB CYP19A1
23 lipoid congenital adrenal hyperplasia 31.3 NR5A1 LHCGR FSHR CYP19A1
24 kallmann syndrome 31.2 TAC3 NR5A1 LHCGR GNRHR FSHR FSHB
25 hypogonadism 31.1 TAC3 LHCGR GNRHR FSHB CYP19A1
26 leydig cell tumor 31.0 NR5A1 LHCGR INHA CYP19A1
27 complete androgen insensitivity syndrome 30.7 NR5A1 LHCGR CYP19A1
28 prostatic cyst 30.5 FSHR EPPIN
29 embryonal testis carcinoma 30.3 EPPIN DAZL
30 disorder of sexual development 30.3 TAC3 NR5A1 LHCGR GNRHR FSHR FSHB
31 pseudohermaphroditism 30.2 NR5A1 LHCGR GNRHR FSHR EPPIN CYP19A1
32 46,xy sex reversal 30.2 NR5A1 LHCGR GNRHR DAZL CYP19A1
33 hermaphroditism 30.2 NR5A1 CYP19A1
34 twinning, dizygotic 30.2 INHA FSHR
35 hydatidiform mole, recurrent, 1 30.0 INHA H19
36 situs inversus 30.0 SPAG1 NPHP4 DNAH5 CCDC39
37 choriocarcinoma 29.9 INHA H19 CYP19A1
38 precocious puberty, male-limited 29.9 LHCGR GNRHR FSHR CYP19A1
39 kartagener syndrome 29.8 SPAG1 DNAH5 CCDC39
40 visceral heterotaxy 29.1 SPAG1 NPHP4 DNAH5 CCDC39
41 spermatogenic failure 5 11.7
42 deafness-infertility syndrome 11.6
43 y chromosome infertility 11.6
44 spermatogenic failure 9 11.5
45 spermatogenic failure 1 11.5
46 spermatogenic failure 6 11.5
47 non-syndromic male infertility due to sperm motility disorder 11.3
48 young syndrome 11.3
49 catsper1-related nonsyndromic male infertility 11.3
50 male infertility with teratozoospermia due to single gene mutation 11.3

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility

Symptoms & Phenotypes for Infertility

UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.13 CYP19A1 DAZ1 DAZ4 DAZL DNAH5 EPPIN
2 digestive/alimentary MP:0005381 9.76 CCDC39 CYP19A1 DNAH5 EPPIN GNRHR INHA
3 cellular MP:0005384 9.73 CCDC39 CYP19A1 DNAH5 FSHB FSHR GNRHR
4 reproductive system MP:0005389 9.5 CYP19A1 DAZ1 DAZ4 DAZL EPPIN FSHB

Drugs & Therapeutics for Infertility

PubMed Health treatment related to Infertility: 63

There are a number of different treatments for infertility . The exact kind of treatment will mainly be determined by what sort of problem has been diagnosed in the woman or man. For instance, hormones may be used if the woman has an abnormal menstrual cycle . Surgery may be helpful if she has fibroids . Some causes of infertility in men can also be treated with hormones or surgery. If not enough sperm is produced or if the sperm cells don't move enough, the semen can be transferred directly to the woman’s womb . This procedure is called insemination. Artificial insemination is also a treatment option if the couple can't have sex or if the sperm can't pass through the cervical mucus . One alternative is artificial fertilization outside the body (in vitro fertilization, or IVF): In this procedure, eggs are removed from the woman’s ovaries through the vagina using a thin hollow needle, and then combined with sperm from the man. Before the eggs are removed, the woman has hormone therapy to stimulate her ovaries to release several mature eggs during the course of a single menstrual cycle . This hormone therapy can have very strong and unpleasant side effects. The actual fertilization takes place outside of the woman's body in a laboratory. In IVF, sperm cells are added to an egg cell and the fertilization process happens on its own. In intracytoplasmic sperm injection (ICSI), one sperm cell is injected directly into an egg using a fine needle. If the fertilization is a success and the egg cells continue to develop, the doctor implants up to three embryos into the womb . In rare cases more egg cells develop into embryos. The woman can then decide to have them frozen (cryopreserved) or destroyed. This also applies to egg cells in a stage of development called the pronuclear stage, in which the chromosome sets from the sperm and egg cells have not yet fully joined together. Cryopreserved embryos or fertilized egg cells can then be thawed out for use in a later cycle if the first transfer is not successful.

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 465)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4 363-24-6, 7448-03-5 5280360
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
3
Iron Approved Phase 4 7439-89-6 29936
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
6
Dienogest Approved Phase 4 65928-58-7 13175121 68861
7
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
8
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
9
Calcium polycarbophil Approved Phase 4 126040-58-2
10
Atosiban Approved, Investigational Phase 4 90779-69-4 21183636 5311010
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
13
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
14
Goserelin Approved Phase 4 65807-02-5 5311128 47725
15
Cabergoline Approved Phase 4 81409-90-7 54746
16
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
17
Dimenhydrinate Approved Phase 4 523-87-5 10660
18
Estrone Approved Phase 4 53-16-7 5870
19
Saw palmetto Approved, Experimental, Investigational Phase 4
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
21
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
22
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
23
Nafarelin Approved Phase 4 76932-56-4 25077649 25077405
24
Sargramostim Approved, Investigational Phase 4 123774-72-1
25
Adenosine Approved, Investigational Phase 4 58-61-7 60961
26
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
27
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
28
Danazol Approved Phase 4 17230-88-5 28417
29
Meperidine Approved Phase 4 57-42-1 4058
30
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
31
Inositol Approved, Investigational, Withdrawn Phase 4 87-89-8
32
Ethiodized oil Approved, Investigational Phase 4 8008-53-5
33
Heparin, bovine Approved, Investigational, Withdrawn Phase 4 9005-49-6 22833565 9812414 772
34
Reviparin Approved, Investigational Phase 4 9041-08-1
35
Bemiparin Approved, Investigational Phase 4 91449-79-5
36
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
37
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
38
Lactitol Approved, Investigational Phase 4 585-86-4, 585-88-6 157355 493591
39
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
40
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
41
Ibuprofen Approved Phase 4 15687-27-1 3672
42
Cetrorelix Approved, Investigational Phase 4 120287-85-6 25074887
43
Dydrogesterone Approved, Investigational, Withdrawn Phase 4 152-62-5 9051
44
Buserelin Approved, Investigational Phase 4 57982-77-1 42615 50225
45
Trimethobenzamide Approved, Investigational Phase 4 138-56-7 5577
46
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715
47
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
48
Prasterone Approved, Investigational, Nutraceutical Phase 4 53-43-0 5881
49
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 5280453
50
Cysteine Approved, Nutraceutical Phase 4 52-90-4 594 5862

Interventional clinical trials:

(show top 50) (show all 2087)
# Name Status NCT ID Phase Drugs
1 Comparison of Oral Dydrogesterone Versus Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles: a Randomized Controlled Trial Unknown status NCT04124913 Phase 4 Dydrogesterone 10 MG Oral Tablet;Progesterone Vaginal Gel [Crinone]
2 An Interventional Study to Assess the Efficacy and Safety of Gonapure® in Multifollicular Stimulation in Egyptian Women Undergoing IVF/ICSI Unknown status NCT03057574 Phase 4 Follitropin Alfa
3 Oxidative Stress In Semen And Male Infertility Unknown status NCT03464656 Phase 4 Fairhaven Pro for men
4 Transdermal Testosterone for Poor Responders Undergoing IVF Unknown status NCT03078569 Phase 4 Testosterone gel
5 Follicular Fluid, Serum Endocrine Profile Following Stimulation With Recombinant Gonadotropins or Highly Purified Human Menopausal Gonadotropin During GnRH-antagonist Protocol Unknown status NCT02992808 Phase 4 recombinant gonadotropins;HP-HMG
6 The Effectiveness and Safety of the Early Follicular Phase Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation: a Randomized, Paralleled, Controlled, Multicenter Trial Unknown status NCT03809221 Phase 4 Triptorelin acetate
7 Effects of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer Unknown status NCT03309436 Phase 4 Clomiphene Citrate protocol
8 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
9 The Effect of Intracervical Lidocaine Versus Intramuscular Diclofenac for Pain Relief During Hysterosalpingography Among Infertile Women In A Tertiary Hospital In Kano: A Randomized Controlled Trial Unknown status NCT02918812 Phase 4 Intracervical lidocaine;Intramuscular Diclofenac
10 Long Acting FSH Plus GnRH Antagonist Versus Daily FSH Plus GnRH Antagonist Versus Short Agonist Regimens in Poor Responder Patients Undergoing IVF: a Randomized Study. Unknown status NCT02070198 Phase 4 Long acting FSH and GnRH antagonist;Daily FSH and GnRH antagonist;Triptorelin and recombinant FSH
11 Double Ovarian Stimulation as Accumulation Strategy for Older Infertile Patients With Suboptimal Ovarian Response in Assisted Reproductive Treatment Unknown status NCT03400722 Phase 4 Pergoveris;Clomiphene
12 A Randomized, the Second-generation Non-ionic Monomer Contrast Parallel Control, Multicenter Clinical Study to Evaluate the Imaging Diagnostic Quality and Fertility Promoting Effect of Ethiodized Poppyseed Oil in Hysterosalpingography of Infertile Patients. Unknown status NCT03370575 Phase 4 ethiodized poppyseed oil;the second-generation non-ionic monomer contrast
13 Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial. Unknown status NCT02140398 Phase 4
14 Clinical Study of the Treatment of Infertility Caused by Severe Intrauterine Adhesions by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
15 Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
16 Different Timing of Intrauterine Insemination and Pregnancy Outcome in Patient With Unexplained Infertility :A Randomized Controlled Study Unknown status NCT03920514 Phase 4 hCG
17 Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome Unknown status NCT03989024 Phase 4 Gonadorelin;Clomiphene
18 Iron Deficiency as an Ignored Cause of Infertility Unknown status NCT04510870 Phase 4 Ferric Carboxymaltose Injection;NaCl infusion
19 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation by Using Recombinant Luteinizing Hormone (rLH) and Recombinant Follicle Stimulating Hormone (rFSH) in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
20 Comparison of Tamoxifen and Clomiphene Citrate in Mild Stimulation IVF: a Prospective Cohort Study Unknown status NCT02690870 Phase 4 Tamoxifen;Clomiphene
21 G-CSF Supplemented Medium for IVF Embryo Culture in Patients Undergoing IVF Unknown status NCT02651285 Phase 4
22 Implantation in Frozen Embryo Transfer Unknown status NCT02655146 Phase 4 triptorelin 0.1;E2;Progesterone;triptorelin 3.75mg
23 Metformin for the Treatment of Unexplained Oligozspermia and Azoospermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
24 Improving Oocyte Retrieval Using a Combined Therapy of Recombinant Follicle Stimulating Hormone (rFSH) and Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
25 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial Unknown status NCT01992731 Phase 4
26 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 11 With and Without Suppression by Dienogest Unknown status NCT02575248 Phase 4 Dienogest 2mg;Clomiphene citrate 5 mg
27 A Comparison Study of a Novel Stimulation Protocol With Metformin in Step-down Regimen and the Conventional Low Dose Step-up Protocol in Patients With Polycystic Ovary Syndrome Undergoing in Vitro Fertilization Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
28 Effect of Sildenafil Citrate on Pregnancy Rate in Women Undergoing Induction of Ovulation Unknown status NCT02890238 Phase 4 Clomiphene citrate;sildenafil citrate;Placebo
29 A Randomized Controlled Trial of the Effect of Influenza Vaccination on Implantation and Pregnancy Rates After Donor Egg Recipient In-Vitro Fertilization Unknown status NCT02946177 Phase 4
30 Luteal Phase Support With Progesterone vs Estrogen and Progesterone on Pregnancy Rates in Ovarian Stimulation and Intrauterine Insemination Cycles: a Prospective Randomized Study Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
31 Cetrorelix and Ganirelix Flexible Protocol for In Vitro Fertilization: a Prospective Randomized Trial Unknown status NCT03477929 Phase 4 Ganirelix Acetate;Cetrorelix Acetate
32 Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI Unknown status NCT02696330 Phase 4 clopidogrel;enoxaparin;placebo
33 A Randomised Controlled Pilot Trial of the Use of GnRH-antagonist Pituitary Suppression During Medicated Frozen-thawed Embryo Transfer (FET) Cycles Unknown status NCT03763786 Phase 4 Cetrorelix Acetate
34 Recombinant hCG (Ovitrelle) Vesrus Urinary hCG (Pregnyl) for Triggering Final Oocyte Maturation in High Responders Unknown status NCT00415766 Phase 4 rHCG 250ug;uHCG 5000 IU;uHCG 7500 IU
35 Randomized Controlled Trial Comparing the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation in Normal Responders Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
36 Randomized, Multicentric and Prospective Clinical Trial to Check the Cost-effectiveness of Corifollitropin Alfa vs. Recombinant FSH and/or HP-hMG Unknown status NCT02213627 Phase 4 Corifollitropin alfa;Recombinant FSH;HP-hMG
37 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
38 Timing of Initiation of Luteal Phase Support in Poor Responders Undergoing IVF/ICSI: a Randomized Controlled Trial Unknown status NCT03938064 Phase 4 Prontogest 400 mg vaginal pessaries
39 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
40 Concomitant Clomiphene Citrate and Estradiol Versus Clomiphene Citrate Alone in Ovulation Induction: a Randomized Controlled Trial Unknown status NCT02186782 Phase 4 Clomiphene citrate and Estradiol;Clomiphene citrate and Placebo
41 Administration of Human Chorionic Gonadotropin (hCG) Versus Gonadotropin Releasing Hormone (GnRH) Agonist for Ovulation Induction in Hyper-Responder Patients Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
42 The Effect of LH-Priming During Early Follicular Phase on Ovarian Response and Pregnancy Outcome in GnRHa Down-Regulated Women, Stimulated With Exogenous Gonadotrophins in IVF Treatment Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
43 The Comparison of Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders: a Prospective Randomized Study. Unknown status NCT01926210 Phase 4
44 Structured Exerise Training in Infertile Obese Patients Treated With Assisted Reproductive Techniques: a Randomized Controlled Trial Unknown status NCT01892111 Phase 4
45 Effect of Endometrial Injury Before Frozen Embryo Transfer on Pregnancy Rate Unknown status NCT03220503 Phase 4
46 Comparison of Clinical Pregnancy Rates Between Two Protocols, With or Without Low Molecular Weight Heparin Administration Before Frozen Embryo Transfer in Hormonal Replacement Cycles: a Prospective Randomized Controlled Trial Unknown status NCT03120715 Phase 4 estrogen;Low Molecular Weight Heparin;hCG;progesterone
47 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation on the Number of Oocytes Obtained During IVF in Poor Ovarian Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
48 Dual Trigger Versus Gonadotropin Releasing Hormone Agonist Trigger Combined With Luteal Human Chorionic Gonadotropin Administration Unknown status NCT02330770 Phase 4 GnRHa and HCG;GnRHa then HCG (single low-dose);GnRHa then HCG (multiple low-doses)
49 Hormone Replacement Therapy Versus Minimal Ovarian Stimulation for Endometrial Preparation Prior to Frozen-thawed Embryo Transfer in Non Polycystic Ovarian Syndrome Patients Unknown status NCT02330757 Phase 4 Estradiol valerate;Sequential Clomiphene citrate and Gonadotropin
50 The Effect of UPA on Women Ovarian Reserve Unknown status NCT02361892 Phase 4 ulipristal acetate

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 71 / NDF-RT 50 :


2-Bromoergocryptine Mesylate
Bromocriptine
Follicle Stimulating Hormone
Follitropin Alfa
follitropin beta
Leuprolide
Leuprolide Acetate
Sermorelin
Sermorelin Acetate

Cochrane evidence based reviews: infertility

Genetic Tests for Infertility

Genetic tests related to Infertility:

# Genetic test Affiliating Genes
1 Infertility 28

Anatomical Context for Infertility

Organs/tissues related to Infertility:

MalaCards : Ovary, Uterus, Pituitary, Bone Marrow, Testis, Kidney, Testes

Publications for Infertility

Articles related to Infertility:

(show top 50) (show all 30208)
# Title Authors PMID Year
1
Pharmacotherapy of infertility in Ghana: Why do infertile patients discontinue their fertility treatment? 62 41
36251650 2022
2
COVID-19 vaccine hesitancy and associated factors among infertile couples undergoing assisted reproductive treatment. 41
36238271 2022
3
Comparing the ICSI outcome between different causes of subfertility and estimate the role of IL-1β in predicting ICSI outcome. 41
36244767 2022
4
A 46, XX SRY - negative man with infertility, and co-existing with chronic autoimmune thyroiditis. 53 62
20170343 2010
5
Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. 53 62
20357175 2010
6
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis. 53 62
19342032 2010
7
Comparison of mild stimulation and conventional stimulation in ART outcome. 53 62
19834718 2010
8
Novel (60%) and recurrent (40%) androgen receptor gene mutations in a series of 59 patients with a 46,XY disorder of sex development. 53 62
20150575 2010
9
Expression of macrophage migration inhibitory factor in human endometriosis: relation to disease stage, menstrual cycle and infertility. 53 62
20492386 2010
10
A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. 53 62
19863670 2010
11
Evaluation of the leptin receptor in human spermatozoa. 53 62
20178606 2010
12
Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSH. 53 62
20061434 2010
13
Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature. 53 62
18996517 2010
14
A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. 53 62
19135657 2010
15
HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility. 53 62
19736237 2009
16
Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment. 53 62
19118825 2009
17
Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice. 53 62
18980760 2009
18
Male infertility and the involvement of the X chromosome. 53 62
19515807 2009
19
Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population. 53 62
19937586 2009
20
Clomiphene and anti-oestrogens for ovulation induction in PCOS. 53 62
19821295 2009
21
RETRACTED: Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial. 53 62
18692823 2009
22
Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility. 53 62
18774560 2009
23
The role of prolactin- and endometriosis-associated infertility. 53 62
19624865 2009
24
Estrogen receptor beta gene mutations in Indian infertile men. 53 62
19509112 2009
25
Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy. 53 62
19647472 2009
26
Length of androgen receptor-CAG repeats in fertile and infertile Egyptian men. 53 62
19168451 2009
27
Aromatase inhibitors for ovulation and pregnancy in polycystic ovary syndrome. 53 62
19584394 2009
28
Disturbances in the LIF pathway in the endometrium among women with unexplained infertility. 53 62
18684446 2009
29
The cystic fibrosis transmembrane conductance regulator in reproductive health and disease. 53 62
19015188 2009
30
Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities. 53 62
18439585 2009
31
Is aromatase expression in the endometrium the cause of endometriosis and related infertility? 53 62
19340622 2009
32
Peritoneal fluid and serum leptin concentrations in women with primary infertility. 53 62
18665375 2009
33
Spermatogenesis in a man with complete deletion of USP9Y. 53 62
19246359 2009
34
CA repeat and RsaI polymorphisms in ERbeta gene are not associated with infertility in Indian men. 53 62
17916182 2009
35
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. 53 62
19129711 2009
36
Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility. 53 62
19089782 2009
37
Leukaemia inhibitory factor (LIF) gene mutations in women diagnosed with unexplained infertility and endometriosis have a negative impact on the IVF outcome. A pilot study. 53 62
19545488 2009
38
First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation. 53 62
18164000 2008
39
Status of serum leptin levels in females with infertility. 53 62
18946565 2008
40
Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility. 53 62
17919612 2008
41
Recombinant HCG for triggering ovulation increases the rate of mature oocytes in women treated for ICSI. 53 62
18925430 2008
42
A relationship between increased peritoneal leptin levels and infertility in endometriosis. 53 62
18958774 2008
43
Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility. 53 62
18567645 2008
44
A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister. 53 62
18508780 2008
45
The AZF proteins. 53 62
18462373 2008
46
Factors affecting live birth rate in intrauterine insemination cycles with recombinant gonadotrophin stimulation. 53 62
18681993 2008
47
Treatment of unexplained infertility with aromatase inhibitors or clomiphene citrate: a systematic review and meta-analysis. 53 62
18559123 2008
48
Purification and characterization of biologically active recombinant human Eppin expressed in Escherichia coli. 53 62
18466682 2008
49
Aromatase inhibitors for infertility in polycystic ovary syndrome. The beginning or the end of a new era? 53 62
18275882 2008
50
A 31-year-old woman with infertility and polycystic ovaries diagnosed with non-classic congenital adrenal hyperplasia due to a novel CYP21 mutation. 53 62
18362511 2008

Variations for Infertility

ClinVar genetic disease variations for Infertility:

5 (show all 23)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GNRHR NM_000406.3(GNRHR):c.317A>G (p.Gln106Arg) SNV Pathogenic
16023 rs104893836 GRCh37: 4:68619737-68619737
GRCh38: 4:67754019-67754019
2 TAC3 NM_013251.4(TAC3):c.248A>G (p.His83Arg) SNV Pathogenic
180150 rs143862988 GRCh37: 12:57406650-57406650
GRCh38: 12:57012866-57012866
3 DNAH5 NM_001369.3(DNAH5):c.6763C>T (p.Arg2255Ter) SNV Pathogenic
454795 rs745918507 GRCh37: 5:13820533-13820533
GRCh38: 5:13820424-13820424
4 CCDC39 NM_181426.2(CCDC39):c.357+1G>C SNV Pathogenic
31067 rs397515392 GRCh37: 3:180379648-180379648
GRCh38: 3:180661860-180661860
5 ZSWIM7 NM_001042697.2(ZSWIM7):c.176C>T (p.Ser59Leu) SNV Likely Pathogenic
1699948 GRCh37: 17:15890605-15890605
GRCh38: 17:15987291-15987291
6 NPHP4 NM_015102.5(NPHP4):c.2044C>T (p.Arg682Ter) SNV Likely Pathogenic
3401 rs137852920 GRCh37: 1:5964776-5964776
GRCh38: 1:5904716-5904716
7 POLR2C NM_032940.3(POLR2C):c.545T>C (p.Val182Ala) SNV Uncertain Significance
872981 rs1567584410 GRCh37: 16:57503978-57503978
GRCh38: 16:57470066-57470066
8 CATSPER2 NM_172095.4(CATSPER2):c.920G>C (p.Trp307Ser) SNV Uncertain Significance
422609 rs146701338 GRCh37: 15:43928340-43928340
GRCh38: 15:43636142-43636142
9 TGFBR3 NM_003243.5(TGFBR3):c.2519C>T (p.Thr840Met) SNV Uncertain Significance
161609 rs193920827 GRCh37: 1:92149333-92149333
GRCh38: 1:91683776-91683776
10 CFTR NM_000492.4(CFTR):c.3409A>G (p.Met1137Val) SNV Uncertain Significance
53733 rs397508553 GRCh37: 7:117254708-117254708
GRCh38: 7:117614654-117614654
11 MYO6 NM_004999.4(MYO6):c.3176G>C (p.Arg1059Thr) SNV Uncertain Significance
45153 rs202214380 GRCh37: 6:76608128-76608128
GRCh38: 6:75898411-75898411
12 DNAI1 NM_012144.4(DNAI1):c.1948C>T (p.Arg650Cys) SNV Uncertain Significance
216677 rs140820295 GRCh37: 9:34517412-34517412
GRCh38: 9:34517414-34517414
13 FGFR1 NM_023110.3(FGFR1):c.2465G>A (p.Arg822His) SNV Uncertain Significance
362891 rs758677681 GRCh37: 8:38271150-38271150
GRCh38: 8:38413632-38413632
14 PROKR2 NM_144773.4(PROKR2):c.518T>G (p.Leu173Arg) SNV Uncertain Significance
3449 rs74315416 GRCh37: 20:5283323-5283323
GRCh38: 20:5302677-5302677
15 DNAAF11 NM_012472.6(DNAAF11):c.27T>G (p.Ile9Met) SNV Uncertain Significance
473106 rs200906172 GRCh37: 8:133673857-133673857
GRCh38: 8:132661611-132661611
16 DNAH5 NM_001369.3(DNAH5):c.5413C>T (p.Arg1805Cys) SNV Uncertain Significance
238981 rs142155986 GRCh37: 5:13841872-13841872
GRCh38: 5:13841763-13841763
17 DNAH11 NM_001277115.2(DNAH11):c.1108C>A (p.Leu370Met) SNV Uncertain Significance
454639 rs189175047 GRCh37: 7:21603929-21603929
GRCh38: 7:21564311-21564311
18 DNAH5 NM_001369.3(DNAH5):c.12251G>A (p.Arg4084Gln) SNV Uncertain Significance
220051 rs140832239 GRCh37: 5:13721137-13721137
GRCh38: 5:13721028-13721028
19 CFTR NM_000492.4(CFTR):c.358G>A (p.Ala120Thr) SNV Uncertain Significance
53774 rs201958172 GRCh37: 7:117171037-117171037
GRCh38: 7:117530983-117530983
20 CCDC103 NM_213607.3(CCDC103):c.461A>C (p.His154Pro) SNV Uncertain Significance
31698 rs145457535 GRCh37: 17:42979917-42979917
GRCh38: 17:44902549-44902549
21 CFTR NM_000492.4(CFTR):c.2900T>C (p.Leu967Ser) SNV Uncertain Significance
219537 rs1800110 GRCh37: 7:117243828-117243828
GRCh38: 7:117603774-117603774
22 CFTR, LOC111674472 NM_000492.4(CFTR):c.2991G>C (p.Leu997Phe) SNV Uncertain Significance
7229 rs1800111 GRCh37: 7:117250575-117250575
GRCh38: 7:117610521-117610521
23 CFTR, CFTR-AS1 NM_000492.4(CFTR):c.1523T>G (p.Phe508Cys) SNV Uncertain Significance
7126 rs74571530 GRCh37: 7:117199648-117199648
GRCh38: 7:117559594-117559594

Copy number variations for Infertility from CNVD:

6 (show all 50)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion infertility
13 266750 Y 1 57772954 Microdeletion infertility
14 266796 Y 11300000 27200000 Deletion AZF1 infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZF1 infertility
17 266827 Y 11300000 27200000 Microdeletion infertility
18 266828 Y 11300000 27200000 Microdeletion infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY1 infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4P1Y infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ1 infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion infertility
27 266840 Y 11300000 27200000 Microdeletion infertility
28 266841 Y 11300000 27200000 Microdeletion infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY1A1 infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF1 infertility
32 266975 Y 174481503 174538309 Microdeletions AZF1 infertility
33 266976 Y 174481503 174538309 Microdeletions AZF1 infertility
34 267088 Y 23407118 25740308 Copy number TTTY17A Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ1 Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4P1Y Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation MT-ATP6 Infertility
49 267527 mtDNA 1 16569 Mutation MT-CYB Infertility
50 267528 1 183532144 183553084 Mutation IVNS1ABP Infertility

Expression for Infertility

Search GEO for disease gene expression data for Infertility.

Pathways for Infertility

Pathways related to Infertility according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 NR5A1 LHCGR GNRHR FSHR FSHB
2
Show member pathways
11.75 LHCGR FSHR FSHB
3 11.17 EPPIN DAZL DAZ4 DAZ1
4 10.72 ZP3 ZP2 NR5A1 LHCGR INHA FSHR
5 10.68 FSHR FSHB
6 10.34 LHCGR GNRHR FSHR FSHB

GO Terms for Infertility

Cellular components related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 egg coat GO:0035805 8.92 ZP3 ZP2

Biological processes related to Infertility according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 spermatogenesis GO:0007283 10.23 LHCGR FSHR FSHB DAZL DAZ4 DAZ1
2 hormone-mediated signaling pathway GO:0009755 9.97 NR5A1 LHCGR FSHR
3 male gonad development GO:0008584 9.97 NR5A1 LHCGR INHA FSHR
4 axonemal dynein complex assembly GO:0070286 9.85 SPAG1 CCDC39
5 single fertilization GO:0007338 9.84 ZP3 ZP2 SPAG1
6 positive regulation of translational initiation GO:0045948 9.8 DAZL DAZ4 DAZ1
7 3'-UTR-mediated mRNA stabilization GO:0070935 9.73 DAZL DAZ4 DAZ1
8 follicle-stimulating hormone signaling pathway GO:0042699 9.71 FSHB FSHR
9 regulation of osteoclast differentiation GO:0045670 9.7 FSHR FSHB
10 regulation of steroid biosynthetic process GO:0050810 9.69 NR5A1 LHCGR
11 Sertoli cell proliferation GO:0060011 9.65 FSHR FSHB
12 ovulation cycle process GO:0022602 9.61 LHCGR FSHR
13 uterus development GO:0060065 9.55 LHCGR FSHR CYP19A1
14 ovarian follicle development GO:0001541 9.43 LHCGR INHA FSHR FSHB
15 female gonad development GO:0008585 9.17 NR5A1 LHCGR FSHR CYP19A1

Molecular functions related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acrosin binding GO:0032190 9.56 ZP3 ZP2
2 structural constituent of egg coat GO:0035804 9.46 ZP3 ZP2
3 translation activator activity GO:0008494 9.43 DAZL DAZ4 DAZ1
4 protein-hormone receptor activity GO:0016500 8.8 LHCGR GNRHR FSHR

Sources for Infertility

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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